- Author:
- WeiweiAi <wai484@aucklanduni.ac.nz>
- Date:
- 2021-10-13 10:54:14+13:00
- Desc:
- Add more Istim protocols
- Permanent Source URI:
- https://models.physiomeproject.org/workspace/6bc/rawfile/de133176b6c4d94462030f98c0689c1b9af45028/Protocols/periodic-IStim-protocol.cellml
<?xml version='1.0' encoding='UTF-8'?>
<model name="periodic_IStim" xmlns="http://www.cellml.org/cellml/1.1#" xmlns:cellml="http://www.cellml.org/cellml/1.1#" xmlns:cmeta="http://www.cellml.org/metadata/1.0#" xmlns:xlink="http://www.w3.org/1999/xlink">
<import xlink:href="../Components/units.cellml">
<units name="ms" units_ref="ms"/>
<units name="pA_per_pF" units_ref="pA_per_pF"/>
<units name="uA_per_cmsq" units_ref="uA_per_cmsq"/>
</import>
<component name="stimulus_protocol">
<variable name="time" public_interface="in" units="ms"/>
<variable name="stimPeriod" public_interface="in" units="ms"/>
<variable name="stimDuration" public_interface="in" units="ms"/>
<variable name="stimCurrent" public_interface="in" units="uA_per_cmsq"/>
<variable name="IStim" public_interface="out" units="uA_per_cmsq"/>
<variable cmeta:id="localTimer" name="t" units="ms"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>t</ci>
<apply>
<minus/>
<ci>time</ci>
<apply>
<times/>
<ci>stimPeriod</ci>
<apply>
<floor/>
<apply>
<divide/>
<ci>time</ci>
<ci>stimPeriod</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply id="stimulus_calculation">
<eq/>
<ci>IStim</ci>
<piecewise>
<piece>
<ci>stimCurrent</ci>
<apply>
<lt/>
<ci>t</ci>
<ci>stimDuration</ci>
</apply>
</piece>
<otherwise>
<cn cellml:units="uA_per_cmsq">0.0</cn>
</otherwise>
</piecewise>
</apply>
</math>
</component>
<component name="sPulse_protocol_ms">
<variable name="time" public_interface="in" units="ms"/>
<variable cmeta:id="hold_time" name="t_ss" public_interface="in" units="ms"/>
<variable cmeta:id="holding_current" name="I_holding" public_interface="in" units="pA_per_pF"/>
<variable cmeta:id="activation_duration" name="t_act" public_interface="in" units="ms"/>
<variable cmeta:id="activation_current" name="I_actTest" public_interface="in" units="pA_per_pF"/>
<variable name="I_stim" public_interface="out" units="pA_per_pF"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply id="stimulus">
<eq/>
<ci>I_stim</ci>
<piecewise>
<piece>
<ci>I_holding</ci>
<apply>
<lt/>
<ci>time</ci>
<ci>t_ss</ci>
</apply>
</piece>
<piece>
<ci>I_actTest</ci>
<apply>
<and/>
<apply>
<geq/>
<ci>time</ci>
<ci>t_ss</ci>
</apply>
<apply>
<lt/>
<ci>time</ci>
<apply>
<plus/>
<ci>t_act</ci>
<ci>t_ss</ci>
</apply>
</apply>
</apply>
</piece>
<otherwise>
<ci>I_holding</ci>
</otherwise>
</piecewise>
</apply>
</math>
</component>
<component name="mPulse_protocol_ms">
<variable name="time" public_interface="in" units="ms"/>
<variable cmeta:id="hold_time" name="t_ss" public_interface="in" units="ms"/>
<variable cmeta:id="holding_current" name="I_holding" public_interface="in" units="pA_per_pF"/>
<variable cmeta:id="activation_duration" name="t_act" public_interface="in" units="ms"/>
<variable cmeta:id="activation_current" name="I_actTest" public_interface="in" units="pA_per_pF"/>
<variable cmeta:id="interpulse" name="t_intp" public_interface="in" units="ms"/>
<variable cmeta:id="period" name="stimPeriod" units="ms"/>
<variable cmeta:id="localTimer" name="t" units="ms"/>
<variable cmeta:id="pulse_number" name="np" public_interface="in" units="dimensionless"/>
<variable name="I_stim" public_interface="out" units="pA_per_pF"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>stimPeriod</ci>
<apply>
<plus/>
<ci>t_act</ci>
<ci>t_intp</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>t</ci>
<apply>
<minus/>
<apply>
<minus/>
<ci>time</ci>
<ci>t_ss</ci>
</apply>
<apply>
<times/>
<ci>stimPeriod</ci>
<apply>
<floor/>
<apply>
<divide/>
<apply>
<minus/>
<ci>time</ci>
<ci>t_ss</ci>
</apply>
<ci>stimPeriod</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply id="stimuli">
<eq/>
<ci>I_stim</ci>
<piecewise>
<piece>
<ci>I_holding</ci>
<apply>
<lt/>
<ci>time</ci>
<ci>t_ss</ci>
</apply>
</piece>
<piece>
<ci>I_actTest</ci>
<apply>
<and/>
<apply>
<geq/>
<ci>time</ci>
<ci>t_ss</ci>
</apply>
<apply>
<leq/>
<ci>t</ci>
<ci>t_act</ci>
</apply>
<apply>
<leq/>
<ci>time</ci>
<apply>
<plus/>
<ci>t_ss</ci>
<apply>
<times/>
<ci>stimPeriod</ci>
<ci>np</ci>
</apply>
</apply>
</apply>
</apply>
</piece>
<otherwise>
<ci>I_holding</ci>
</otherwise>
</piecewise>
</apply>
</math>
</component>
</model>
