- Author:
- WeiweiAi <wai484@aucklanduni.ac.nz>
- Date:
- 2021-07-06 11:22:35+12:00
- Desc:
- Change the figures size to fit the Physiome paper;
Adjust the solver setting to remove the notch in Fig6.
Minor editting in README.
- Permanent Source URI:
- https://models.physiomeproject.org/workspace/692/rawfile/b98a10f69ee76a70243efdb648c598db5a866a2c/Components/ICaL_off.cellml
<?xml version='1.0' encoding='UTF-8'?>
<model name="ICaL" xmlns="http://www.cellml.org/cellml/1.1#" xmlns:cellml="http://www.cellml.org/cellml/1.1#" xmlns:xlink="http://www.w3.org/1999/xlink">
<import xlink:href="units.cellml">
<units name="mM" units_ref="mM"/>
<units name="ms" units_ref="ms"/>
<units name="pA" units_ref="pA"/>
<units name="mV" units_ref="mV"/>
<units name="nS" units_ref="nS"/>
</import>
<import xlink:href="Ionic_currents.cellml">
<component component_ref="Ionic_currents" name="Ionic_currents"/>
</import>
<import xlink:href="E_Nernst.cellml">
<component component_ref="E_Ca" name="E_Ca"/>
</import>
<import xlink:href="ICaL_channel_states_off.cellml">
<component component_ref="ICaL_channel_states" name="ICaL_channel_states"/>
</import>
<component name="ICaL">
<variable name="time" private_interface="out" public_interface="in" units="ms"/>
<variable name="P_CaL" private_interface="in" public_interface="out" units="dimensionless"/>
<variable name="I_CaL" private_interface="in" public_interface="out" units="pA"/>
<variable name="V" private_interface="out" public_interface="in" units="mV"/>
<variable name="g_CaL" private_interface="out" public_interface="in" units="nS"/>
<variable name="T" private_interface="out" public_interface="in" units="kelvin"/>
<variable name="T0CaL" private_interface="out" public_interface="in" units="kelvin"/>
<variable name="Q10Ca" private_interface="out" public_interface="in" units="dimensionless"/>
<variable name="Cao" private_interface="out" public_interface="in" units="mM"/>
<variable name="Cai" private_interface="out" public_interface="in" units="mM"/>
<variable name="C0_init" private_interface="out" public_interface="in" units="dimensionless"/>
<variable name="C1_init" private_interface="out" public_interface="in" units="dimensionless"/>
<variable name="C2_init" private_interface="out" public_interface="in" units="dimensionless"/>
<variable name="C3_init" private_interface="out" public_interface="in" units="dimensionless"/>
<variable name="C0Ca_init" private_interface="out" public_interface="in" units="dimensionless"/>
<variable name="C1Ca_init" private_interface="out" public_interface="in" units="dimensionless"/>
<variable name="C2Ca_init" private_interface="out" public_interface="in" units="dimensionless"/>
<variable name="C3Ca_init" private_interface="out" public_interface="in" units="dimensionless"/>
<variable name="ICa_init" private_interface="out" public_interface="in" units="dimensionless"/>
<variable name="IVs_init" private_interface="out" public_interface="in" units="dimensionless"/>
<variable name="IVf_init" private_interface="out" public_interface="in" units="dimensionless"/>
<variable name="IVfCa_init" private_interface="out" public_interface="in" units="dimensionless"/>
<variable name="IVsCa_init" private_interface="out" public_interface="in" units="dimensionless"/>
<variable name="O_CaL_init" private_interface="out" public_interface="in" units="dimensionless"/>
</component>
<group>
<relationship_ref relationship="encapsulation"/>
<component_ref component="ICaL">
<component_ref component="Ionic_currents"/>
<component_ref component="E_Ca"/>
<component_ref component="ICaL_channel_states"/>
</component_ref>
</group>
<connection>
<map_components component_1="ICaL" component_2="Ionic_currents"/>
<map_variables variable_1="I_CaL" variable_2="I"/>
<map_variables variable_1="V" variable_2="V"/>
<map_variables variable_1="g_CaL" variable_2="g_max"/>
</connection>
<connection>
<map_components component_1="ICaL" component_2="E_Ca"/>
<map_variables variable_1="T" variable_2="T"/>
<map_variables variable_1="Cai" variable_2="Cai"/>
<map_variables variable_1="Cao" variable_2="Cao"/>
</connection>
<connection>
<map_components component_1="E_Ca" component_2="Ionic_currents"/>
<map_variables variable_1="E_Ca" variable_2="E"/>
</connection>
<connection>
<map_components component_1="ICaL_channel_states" component_2="Ionic_currents"/>
<map_variables variable_1="O_CaL" variable_2="PO"/>
</connection>
<connection>
<map_components component_1="ICaL" component_2="ICaL_channel_states"/>
<map_variables variable_1="time" variable_2="time"/>
<map_variables variable_1="P_CaL" variable_2="O_CaL"/>
<map_variables variable_1="V" variable_2="V"/>
<map_variables variable_1="T" variable_2="T"/>
<map_variables variable_1="Cai" variable_2="Cai"/>
<map_variables variable_1="T0CaL" variable_2="T0"/>
<map_variables variable_1="Q10Ca" variable_2="Q10Ca"/>
<map_variables variable_1="C0_init" variable_2="C0_init"/>
<map_variables variable_1="C1_init" variable_2="C1_init"/>
<map_variables variable_1="C2_init" variable_2="C2_init"/>
<map_variables variable_1="C3_init" variable_2="C3_init"/>
<map_variables variable_1="C0Ca_init" variable_2="C0Ca_init"/>
<map_variables variable_1="C1Ca_init" variable_2="C1Ca_init"/>
<map_variables variable_1="C2Ca_init" variable_2="C2Ca_init"/>
<map_variables variable_1="C3Ca_init" variable_2="C3Ca_init"/>
<map_variables variable_1="ICa_init" variable_2="ICa_init"/>
<map_variables variable_1="IVs_init" variable_2="IVs_init"/>
<map_variables variable_1="IVf_init" variable_2="IVf_init"/>
<map_variables variable_1="IVfCa_init" variable_2="IVfCa_init"/>
<map_variables variable_1="IVsCa_init" variable_2="IVsCa_init"/>
<map_variables variable_1="O_CaL_init" variable_2="O_CaL_init"/>
</connection>
</model>
