- Author:
- WeiweiAi <wai484@aucklanduni.ac.nz>
- Date:
- 2021-06-08 16:57:08+12:00
- Desc:
- Modify tau_dCaT to 1.9508 and the parameter in phi_s (0.05956) to 0.005956 (Eq S-24) based on the C code;
Add ICaL_channel_states_off and ICaL_off for Clamped_current_Xi to switch off the Cai dependency.
- Permanent Source URI:
- https://models.physiomeproject.org/workspace/692/rawfile/ad6aa57de38320e52058da97f9d140a57288d95e/Simulation/Fig3_sim.py
# To reproduce the data needed for Figure 7 in associated original paper,
# execute this script in the Python console in OpenCOR. This can be done
# with the following commands at the prompt in the OpenCOR Python console:
#
# In [1]: cd path/to/folder_this_file_is_in
# In [2]: Fig3_sim.py
import opencor as oc
import numpy as np
# The prefix of the saved output file name
prefilename = 'simFig3'
# Load the simulation file
simfile='Patch_clampXi_experiment.sedml'
simulation = oc.open_simulation(simfile)
# The data object houses all the relevant information
# and pointers to the OpenCOR internal data representations
data = simulation.data()
# Set the experiments
Vholding, t_ss = -100, 1000
Vtest = range (-90, 50, 5)
duration = 400
# Define the interval of interest for this simulation experiment
start, end, pointInterval = 0, t_ss+duration, 0.1
data.set_starting_point(start)
data.set_ending_point(end)
data.set_point_interval(pointInterval)
# Data to save
varName = np.array(["V", "ICaT"])
vars = np.reshape(varName, (1, len(varName)))
row_start=int(t_ss/pointInterval-50) # to get the peak
r = np.zeros((len(Vtest),len(varName)))
for i, V in enumerate(Vtest):
# Reset states and parameters
simulation.reset(True)
# Set constant parameter values
data.constants()['Clamp_parameters/V_actHolding'] = Vholding
data.constants()['Clamp_parameters/V_actTest'] = V
simulation.run()
# Access simulation results
results = simulation.results()
# Grab a specific algebraic variable results
r[i,0] = V
temp = results.algebraic()['outputs/I_CaT'].values()[row_start:]
r[i,1] = -max(abs(temp))
# clear the results except the last run
simulation.clear_results()
# Save the simulation result of the last run
filename='%s.csv' % (prefilename)
np.savetxt(filename, vars, fmt='%s',delimiter=",")
with open(filename, "ab") as f:
np.savetxt(f, r, delimiter=",")
f.close
