Location: Model of Human Jejunal Smooth Muscle Cell Electrophysiology @ ad6aa57de383 / Experiments / Periodic_IStim_protocol.cellml
- Author:
- WeiweiAi <wai484@aucklanduni.ac.nz>
- Date:
- 2021-06-08 16:57:08+12:00
- Desc:
- Modify tau_dCaT to 1.9508 and the parameter in phi_s (0.05956) to 0.005956 (Eq S-24) based on the C code; Add ICaL_channel_states_off and ICaL_off for Clamped_current_Xi to switch off the Cai dependency.
- Permanent Source URI:
- https://models.physiomeproject.org/workspace/692/rawfile/ad6aa57de38320e52058da97f9d140a57288d95e/Experiments/Periodic_IStim_protocol.cellml
<?xml version='1.0' encoding='UTF-8'?>
<model name="Periodic_IStim_protocol" xmlns="http://www.cellml.org/cellml/1.1#" xmlns:cellml="http://www.cellml.org/cellml/1.1#" xmlns:xlink="http://www.w3.org/1999/xlink">
<import xlink:href="../Components/units.cellml">
<units name="ms" units_ref="ms"/>
<units name="pA" units_ref="pA"/>
<units name="mV" units_ref="mV"/>
<units name="nS" units_ref="nS"/>
</import>
<component name="Periodic_IStim_protocol">
<variable name="I_stim" public_interface="out" units="pA"/>
<variable name="V_ICC" public_interface="out" units="mV"/>
<variable name="time" public_interface="in" units="ms"/>
<variable name="V" public_interface="in" units="mV"/>
<variable name="t_period" public_interface="in" units="ms"/>
<variable name="Gcouple" public_interface="in" units="nS"/>
<variable name="V_ICCrest" public_interface="in" units="mV"/>
<variable name="V_ICCamp" public_interface="in" units="mV"/>
<variable name="t_ICCpeak" public_interface="in" units="ms"/>
<variable name="t_slope" public_interface="in" units="ms"/>
<variable name="f_1" public_interface="in" units="ms"/>
<variable name="f_2" public_interface="in" units="ms"/>
<variable name="t" units="ms"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>I_stim</ci>
<apply>
<times/>
<ci>Gcouple</ci>
<apply>
<minus/>
<ci>V</ci>
<ci>V_ICC</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>t</ci>
<apply>
<rem/>
<ci>time</ci>
<ci>t_period</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>V_ICC</ci>
<piecewise>
<piece>
<apply>
<plus/>
<ci>V_ICCrest</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>V_ICCamp</ci>
<ci>t</ci>
</apply>
<ci>f_2</ci>
</apply>
</apply>
<apply>
<lt/>
<ci>t</ci>
<ci>t_ICCpeak</ci>
</apply>
</piece>
<otherwise>
<apply>
<plus/>
<ci>V_ICCrest</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>V_ICCamp</ci>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<ci>f_1</ci>
</apply>
<apply>
<times/>
<cn cellml:units="dimensionless">2</cn>
<ci>t_slope</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<apply>
<minus/>
<ci>t</ci>
<ci>f_2</ci>
</apply>
<apply>
<times/>
<cn cellml:units="dimensionless">0.5</cn>
<ci>f_1</ci>
</apply>
</apply>
<ci>t_slope</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</otherwise>
</piecewise>
</apply>
</math>
</component>
</model>