- Author:
- WeiweiAi <wai484@aucklanduni.ac.nz>
- Date:
- 2021-06-21 15:17:22+12:00
- Desc:
- Add comments for paramater difference from difference sources in default_values.cellml
Add T and Cao in the patch experiment to simulate fig 11;
Add T in the periodic stimulation experiment; Add fig 10 and 11;
Rerun the simulation and update the documentation.
- Permanent Source URI:
- https://models.physiomeproject.org/workspace/692/rawfile/83d7d73639ae18c0fea6c0befe2b40552ab06de6/Doc/Patch_clampXi_experiment.rst
Voltage clamp experiment
------------------------
In the `Voltage clamp experiment <../Experiments/Patch_clampXi_experiment.cellml>`_, the `Clamped current component <../Components/Clamped_current_Xi.cellml/view>`_ is configured and parameterised with an applied `Patch clamp protocol <../Experiments/Patch_clamp_protocol.cellml>`_.
You can change the clamping parameters in the component ``Clamp_parameters``.
You can also bypass the parameters in the component ``model_parameters`` and ``initial_conditions`` and define your own parameters.
The simulation experiment can be obtained by loading the `corresponding SED-ML document <../Simulation/Patch_clampXi_experiment.sedml>`__ into OpenCOR and executing the simulation.
Clamped :math:`I_{CaL}`
-------------------------
Figure [#]_ shows normalized L-type calcium channels peak I–V plot for simulated data derived from the publication(dots) and the current CellML model (solid line) with different intracelluar concentrations.
.. [#]
.. figure:: ../Simulation/simFig2.png
:width: 85%
:align: center
:alt: simFig2
Clamped :math:`I_{CaT}`
-------------------------
Figure [#]_ shows normalized T-type calcium channels peak I–V plot for simulated data derived from the publication(dots) and the current CellML model (solid line) with different intracelluar concentrations.
.. [#]
.. figure:: ../Simulation/simFig3.png
:width: 85%
:align: center
:alt: simFig3
Clamped :math:`I_{Kv}`
-------------------------
Figure [#]_ shows normalized I–V plot of whole cell voltage-activated potassium currents for simulated data derived from the publication(dots) and the current CellML model (solid line).
.. [#]
.. figure:: ../Simulation/simFig4.png
:width: 85%
:align: center
:alt: simFig4
Clamped :math:`P_{BK}`
-------------------------
Figure [#]_ shows Open probability of BK channel versus clamping voltage (@ various :math:`Ca_i^{2+}`) for simulated data derived from the publication(dots) and the current CellML model (solid line).
.. [#]
.. figure:: ../Simulation/simFig5.png
:width: 85%
:align: center
:alt: simFig5
Clamped :math:`I_{Na}`
-------------------------
Figure [#]_ shows normalized :math:`Na_^{+}` channel peak I–V plot for simulated data derived from the publication(dots) and the current CellML model (solid line) with different intracelluar concentrations.
.. [#]
.. figure:: ../Simulation/simFig6.png
:width: 85%
:align: center
:alt: simFig6
Figure [#]_ shows whole cell current versus time traces subjected to voltage clamp at different holding voltages for simulated data derived from the publication(dots) and the current CellML model (solid line).
.. [#]
.. figure:: ../Simulation/simFig10.png
:width: 85%
:align: center
:alt: simFig10
Figure [#]_ shows whole cell normalized I–V data from hJSMC model under near calcium-free conditions for simulated data derived from the publication(dots) and the current CellML model (solid line).
.. [#]
.. figure:: ../Simulation/simFig11.png
:width: 85%
:align: center
:alt: simFig11
