- Author:
- WeiweiAi <wai484@aucklanduni.ac.nz>
- Date:
- 2021-06-21 15:17:22+12:00
- Desc:
- Add comments for paramater difference from difference sources in default_values.cellml
Add T and Cao in the patch experiment to simulate fig 11;
Add T in the periodic stimulation experiment; Add fig 10 and 11;
Rerun the simulation and update the documentation.
- Permanent Source URI:
- https://models.physiomeproject.org/workspace/692/rawfile/83d7d73639ae18c0fea6c0befe2b40552ab06de6/Doc/Clamped_current_Xi.rst
Clamped current model
------------------------
The `Clamped current component <../Components/Clamped_current_Xi.cellml>`_ defines the complete `equations of the total ionic current <../Components/Clamped_current_Xi.cellml/cellml_math>`_.
It combines the imported ionic current components:
- L-type :math:`Ca^{2+}` channels: `ICaL <../Components/ICaL.cellml>`_
It instantiates the imported `Ionic currents component <../Components/Ionic_currents.cellml>`_ with computed :math:`PO` using `ICaL channel states component <../Components/ICaL_channel_states.cellml>`_, while the Nernst potential :math:`E_{Ca}` computation is defined by the `Nernst potential component <../Components/E_Nernst.cellml>`_.
- T-type :math:`Ca^{2+}` channels: `ICaT <../Components/ICaT.cellml>`_
It instantiates the imported `Ionic currents component`_ with computed :math:`PO` using `ICaT channel states component <../Components/ICaT_channel_states.cellml>`_, while the Nernst potential :math:`E_{Ca}` computation is defined by the `Nernst potential component`_.
- Voltage dependent :math:`K^{+}` channels: `IKv <Components/IKv.cellml>`_
It instantiates the imported `Ionic currents component`_ with computed :math:`P_{Kv} = x_{Kv}*y_{Kv}`. The gating kinetics is defined in the imported `gating kinetics component <../Components/gating_kinetics.cellml>`_, while the steady states of x and y gate are defined by the imported `IKv gating steady state component <../Components/IKv_gating_inf.cellml>`_, the Nernst potential :math:`E_{K}` computation is defined by the `Nernst potential component`_.
- Large conductance :math:`Ca^{2+}` and voltage activated :math:`K^{+}` channels: `IBK <Components/IBK.cellml>`_
It instantiates the imported `Ionic currents component`_ with computed :math:`PO` using `IBK channel states component <../Components/IBK_channel_states.cellml>`_, while the Nernst potential :math:`E_{K}` computation is defined by the `Nernst potential component`_.
- :math:`Na^{+}` channels: `INa <Components/INa.cellml>`_
It instantiates the imported `Ionic currents component`_ with computed :math:`PO` using `INa channel states component <../Components/INa_channel_states.cellml>`_, while the Nernst potential :math:`E_{Na}` computation is defined by the `Nernst potential component`_.
- :math:`Na^{+}`- :math:`K^{+}` pump: `INaK <Components/INaK.cellml>`_
- :math:`Na^{+}`- :math:`Ca^{2+}` exchanger: `INCX <Components/INCX.cellml>`_
- Non-selective sodium leak current: `INS_Na <Components/INS_Na.cellml>`_
- Non-selective potassium leak current: `INS_K <Components/INS_K.cellml>`_
The intracellular ionic concentrations :math:`Ca_i^{2+}`, :math:`Na_i^{+}` and :math:`K_i^{+}` should be given by the clamping parameters.
