- Author:
- Dewan Sarwar <sarwarcse@gmail.com>
- Date:
- 2019-03-11 12:09:49+13:00
- Desc:
- added blood capillary flux model
- Permanent Source URI:
- https://models.physiomeproject.org/workspace/584/rawfile/dcab0d9157ad4fb602c5084666c323fb3e30323a/semgen_annotated_models/MacKenzie_1996.cellml
<?xml version="1.0" encoding="UTF-8"?>
<model xmlns="http://www.cellml.org/cellml/1.1#" xmlns:cmeta="http://www.cellml.org/metadata/1.0#" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bqs="http://www.cellml.org/bqs/1.0#" xmlns:semsim="http://www.bhi.washington.edu/SemSim#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" name="mackenzie_1996" cmeta:id="mackenzie_1996">
<documentation xmlns="http://cellml.org/tmp-documentation">
<article>
<articleinfo>
<title>Biophysical Characteristics of the Pig Kidney Na/Glucose Cotransporter SGLT2 Reveal a Common Mechanism for SGLT1 and SGLT2</title>
<author>
<firstname>Jonna</firstname>
<surname>Terkildsen</surname>
<affiliation>
<shortaffil>Auckland Bioengineering Institute, University of Auckland</shortaffil>
</affiliation>
</author>
</articleinfo>
<sect1 id="sec_status">
<title>Model Status</title>
<para>This CellML model has been curated, the units are consistent and the model runs in COR and PCEnv. This model recreates the published results.</para>
</sect1>
<sect1 id="sec_structure">
<title>Model Structure</title>
<para>Abstract: The Na-dependent, low affinity glucose transporter SGLT2 cloned from pig kidney is 76% identical (at the amino acid level) to its high affinity homologue SGLT1. Using two-microelectrode voltage clamp, we have characterized the presteady-state and steady-state kinetics of SGLT2 expressed in Xenopus oocytes. The kinetic properties of the steady-state sugar-evoked currents as a function of external Na and a-methyl-D-glucopyranoside (aMG) concentrations were consistent with an ordered, simultaneous transport model in which Na binds first. Na binding was voltage-dependent and saturated with hyperpolarizing voltages. Phlorizin was a potent inhibitor of the sugar-evoked currents (Ki ~10 mM) and blocked an inward Na current in the absence of sugar. SGLT2 exhibited Na-dependent presteadystate currents with time constants 3-7 ms. Charge movements were described by Boltzmann relations with apparent valence ~1 and maximal charge transfer ~11 nC, and were reduced by the addition of sugar or phlorizin. The differences between SGLT1 and SGLT2 were that (i) the apparent affinity constant (K0.5) for aMG (~3 mM) was an order of magnitude higher for SGLT2; (ii) SGLT2 excluded galactose, suggesting discrete sugar binding; (iii) K0.5 for Na was lower in SGLT2; and (iv) the Hill coefficient for Na was 1 for SGLT2 but 2 for SGLT1. Simulations of the six-state kinetic model previously proposed for SGLT1 indicated that many of the kinetic properties observed in SGLT2 are expected by simply reducing the Na/glucose coupling from 2 to 1.</para>
<para>The original paper reference is cited below:</para>
<para>
Biophysical Characteristics of the Pig Kidney Na/Glucose Cotransporter SGLT2 Reveal a Common Mechanism for SGLT1 and SGLT2, M. Mackenzie, D.D.F. Loo, M. Panayotova-Heiermann, and E. M. Wright, 1996,
<emphasis>Journal of Biological Chemistry</emphasis>
, 271, 32678-32683.
<ulink url="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=8955098&query_hl=1&itool=pubmed_docsum">PubMed ID: 8955098</ulink>
</para>
<informalfigure float="0" id="fig_reaction_diagram">
<mediaobject>
<imageobject>
<objectinfo>
<title>model diagram</title>
</objectinfo>
<imagedata fileref="mackenzie_1996.png" />
</imageobject>
</mediaobject>
<caption>Schematic diagram of the Mackenzie et al 1996 SGLT2 model. C' represents the external-facing carrier. C'' represents the internal-facing carrier.</caption>
</informalfigure>
</sect1>
</article>
</documentation>
<units name="M">
<unit units="mole" />
<unit exponent="-1.0" units="litre" />
</units>
<units name="C_per_mol">
<unit units="coulomb" />
<unit exponent="-1.0" units="mole" />
</units>
<units name="per_M2_per_second5">
<unit exponent="-2.0" units="M" />
<unit exponent="-5.0" units="second" />
</units>
<units name="M_per_second">
<unit units="M" />
<unit exponent="-1.0" units="second" />
</units>
<units name="J_per_K_per_mol">
<unit exponent="-1.0" units="mole" />
<unit exponent="-1.0" units="kelvin" />
<unit units="joule" />
</units>
<units name="per_second5">
<unit exponent="-5.0" units="second" />
</units>
<units name="M2_per_second">
<unit exponent="2.0" units="M" />
<unit exponent="-1.0" units="second" />
</units>
<units name="M2">
<unit exponent="2.0" units="M" />
</units>
<units name="uA">
<unit prefix="micro" units="ampere" />
</units>
<units name="um2">
<unit exponent="2.0" prefix="micro" units="metre" />
</units>
<units name="per_M_per_second">
<unit exponent="-1.0" units="second" />
<unit exponent="-1.0" units="M" />
</units>
<units name="per_mol">
<unit exponent="-1.0" units="mole" />
</units>
<units name="umol_per_second">
<unit exponent="-1.0" units="second" />
<unit units="umol" />
</units>
<units name="per_second">
<unit exponent="-1.0" units="second" />
</units>
<units name="umol">
<unit prefix="micro" units="mole" />
</units>
<component name="parameters">
<variable cmeta:id="parameters.T" name="T" public_interface="out" units="kelvin" />
<variable cmeta:id="parameters.V" name="V" public_interface="in" units="volt" />
<variable cmeta:id="parameters.delta" name="delta" public_interface="out" units="dimensionless" />
<variable cmeta:id="parameters.k0_16" name="k0_16" public_interface="out" units="per_second" />
<variable cmeta:id="parameters.N_C" name="N_C" units="dimensionless" />
<variable cmeta:id="parameters.k0_32" name="k0_32" public_interface="out" units="per_second" />
<variable cmeta:id="parameters.k0_54" name="k0_54" public_interface="out" units="per_M_per_second" />
<variable cmeta:id="parameters.z_Na" name="z_Na" public_interface="out" units="dimensionless" />
<variable cmeta:id="parameters.k0_12" name="k0_12" public_interface="out" units="per_M_per_second" />
<variable cmeta:id="parameters.k0_34" name="k0_34" public_interface="out" units="per_second" />
<variable cmeta:id="parameters.k0_56" name="k0_56" public_interface="out" units="per_second" />
<variable cmeta:id="parameters.k0_52" name="k0_52" public_interface="out" units="per_second" />
<variable cmeta:id="parameters.F" name="F" public_interface="out" units="C_per_mol" />
<variable cmeta:id="parameters.C_T" name="C_T" public_interface="out" units="umol" />
<variable cmeta:id="parameters.z_c" name="z_c" public_interface="out" units="dimensionless" />
<variable cmeta:id="parameters.R" name="R" public_interface="out" units="J_per_K_per_mol" />
<variable cmeta:id="parameters.k0_25" name="k0_25" public_interface="out" units="per_second" />
<variable cmeta:id="parameters.mu" name="mu" public_interface="out" units="dimensionless" />
<variable cmeta:id="parameters.k0_21" name="k0_21" public_interface="out" units="per_second" />
<variable cmeta:id="parameters.k0_43" name="k0_43" public_interface="out" units="per_second" />
<variable cmeta:id="parameters.k0_65" name="k0_65" public_interface="out" units="per_M_per_second" />
<variable cmeta:id="parameters.k0_23" name="k0_23" public_interface="out" units="per_M_per_second" />
<variable cmeta:id="parameters.k0_45" name="k0_45" public_interface="out" units="per_second" />
<variable cmeta:id="parameters.k0_61" name="k0_61" public_interface="out" units="per_second" />
<variable cmeta:id="parameters.alpha_pp" name="alpha_pp" public_interface="out" units="dimensionless" />
<variable cmeta:id="parameters.area" name="area" units="um2" />
<variable cmeta:id="parameters.n" name="n" public_interface="out" units="dimensionless" />
<variable cmeta:id="parameters.N_Avo" name="N_Avo" units="per_mol" />
<variable cmeta:id="parameters.alpha_p" name="alpha_p" public_interface="out" units="dimensionless" />
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq />
<ci>alpha_p</ci>
<apply>
<minus />
<apply>
<minus />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<ci>delta</ci>
</apply>
<ci>alpha_pp</ci>
</apply>
</apply>
<apply>
<eq />
<ci>C_T</ci>
<apply>
<divide />
<apply>
<times />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" type="e-notation" cellml:units="umol_per_mol">
1
<sep />
6
</cn>
<ci>N_C</ci>
</apply>
<ci>N_Avo</ci>
</apply>
</apply>
<apply>
<eq />
<ci>mu</ci>
<apply>
<divide />
<apply>
<times />
<ci>F</ci>
<ci>V</ci>
</apply>
<apply>
<times />
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="king_altman_states">
<variable cmeta:id="king_altman_states.C2_sum" name="C2_sum" units="per_second5" />
<variable cmeta:id="king_altman_states.k_16" name="k_16" public_interface="in" units="per_second" />
<variable cmeta:id="king_altman_states.C3_sum" name="C3_sum" units="per_second5" />
<variable cmeta:id="king_altman_states.k_12" name="k_12" public_interface="in" units="per_second" />
<variable cmeta:id="king_altman_states.k_34" name="k_34" public_interface="in" units="per_second" />
<variable cmeta:id="king_altman_states.k_56" name="k_56" public_interface="in" units="per_second" />
<variable cmeta:id="king_altman_states.C_T" name="C_T" public_interface="in" units="umol" />
<variable cmeta:id="king_altman_states.C_sum" name="C_sum" units="per_second5" />
<variable cmeta:id="king_altman_states.k_32" name="k_32" public_interface="in" units="per_second" />
<variable cmeta:id="king_altman_states.k_54" name="k_54" public_interface="in" units="per_second" />
<variable cmeta:id="king_altman_states.k_52" name="k_52" public_interface="in" units="per_second" />
<variable cmeta:id="king_altman_states.C4_sum" name="C4_sum" units="per_second5" />
<variable cmeta:id="king_altman_states.C4" name="C4" public_interface="out" units="umol" />
<variable cmeta:id="king_altman_states.C3" name="C3" public_interface="out" units="umol" />
<variable cmeta:id="king_altman_states.C2" name="C2" public_interface="out" units="umol" />
<variable cmeta:id="king_altman_states.C1" name="C1" public_interface="out" units="umol" />
<variable cmeta:id="king_altman_states.C5_sum" name="C5_sum" units="per_second5" />
<variable cmeta:id="king_altman_states.C6" name="C6" public_interface="out" units="umol" />
<variable cmeta:id="king_altman_states.C5" name="C5" public_interface="out" units="umol" />
<variable cmeta:id="king_altman_states.k_25" name="k_25" public_interface="in" units="per_second" />
<variable cmeta:id="king_altman_states.C1_sum" name="C1_sum" units="per_second5" />
<variable cmeta:id="king_altman_states.k_23" name="k_23" public_interface="in" units="per_second" />
<variable cmeta:id="king_altman_states.k_45" name="k_45" public_interface="in" units="per_second" />
<variable cmeta:id="king_altman_states.k_21" name="k_21" public_interface="in" units="per_second" />
<variable cmeta:id="king_altman_states.k_43" name="k_43" public_interface="in" units="per_second" />
<variable cmeta:id="king_altman_states.k_65" name="k_65" public_interface="in" units="per_second" />
<variable cmeta:id="king_altman_states.k_61" name="k_61" public_interface="in" units="per_second" />
<variable cmeta:id="king_altman_states.C6_sum" name="C6_sum" units="per_second5" />
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq />
<ci>C1_sum</ci>
<apply>
<plus />
<apply>
<times />
<ci>k_21</ci>
<ci>k_32</ci>
<ci>k_43</ci>
<ci>k_54</ci>
<ci>k_65</ci>
</apply>
<apply>
<times />
<ci>k_21</ci>
<ci>k_34</ci>
<ci>k_45</ci>
<ci>k_52</ci>
<ci>k_65</ci>
</apply>
<apply>
<times />
<ci>k_21</ci>
<ci>k_32</ci>
<ci>k_45</ci>
<ci>k_52</ci>
<ci>k_65</ci>
</apply>
<apply>
<times />
<ci>k_21</ci>
<ci>k_32</ci>
<ci>k_43</ci>
<ci>k_52</ci>
<ci>k_65</ci>
</apply>
<apply>
<times />
<ci>k_25</ci>
<ci>k_34</ci>
<ci>k_45</ci>
<ci>k_56</ci>
<ci>k_61</ci>
</apply>
<apply>
<times />
<ci>k_23</ci>
<ci>k_34</ci>
<ci>k_45</ci>
<ci>k_56</ci>
<ci>k_61</ci>
</apply>
<apply>
<times />
<ci>k_21</ci>
<ci>k_34</ci>
<ci>k_45</ci>
<ci>k_56</ci>
<ci>k_61</ci>
</apply>
<apply>
<times />
<ci>k_25</ci>
<ci>k_32</ci>
<ci>k_45</ci>
<ci>k_56</ci>
<ci>k_61</ci>
</apply>
<apply>
<times />
<ci>k_21</ci>
<ci>k_32</ci>
<ci>k_45</ci>
<ci>k_56</ci>
<ci>k_61</ci>
</apply>
<apply>
<times />
<ci>k_25</ci>
<ci>k_32</ci>
<ci>k_43</ci>
<ci>k_56</ci>
<ci>k_61</ci>
</apply>
<apply>
<times />
<ci>k_21</ci>
<ci>k_32</ci>
<ci>k_43</ci>
<ci>k_56</ci>
<ci>k_61</ci>
</apply>
<apply>
<times />
<ci>k_21</ci>
<ci>k_32</ci>
<ci>k_43</ci>
<ci>k_54</ci>
<ci>k_61</ci>
</apply>
<apply>
<times />
<ci>k_21</ci>
<ci>k_34</ci>
<ci>k_45</ci>
<ci>k_52</ci>
<ci>k_61</ci>
</apply>
<apply>
<times />
<ci>k_21</ci>
<ci>k_32</ci>
<ci>k_45</ci>
<ci>k_52</ci>
<ci>k_61</ci>
</apply>
<apply>
<times />
<ci>k_21</ci>
<ci>k_32</ci>
<ci>k_43</ci>
<ci>k_52</ci>
<ci>k_61</ci>
</apply>
</apply>
</apply>
<apply>
<eq />
<ci>C2_sum</ci>
<apply>
<plus />
<apply>
<times />
<ci>k_16</ci>
<ci>k_32</ci>
<ci>k_43</ci>
<ci>k_54</ci>
<ci>k_65</ci>
</apply>
<apply>
<times />
<ci>k_12</ci>
<ci>k_32</ci>
<ci>k_43</ci>
<ci>k_54</ci>
<ci>k_65</ci>
</apply>
<apply>
<times />
<ci>k_16</ci>
<ci>k_34</ci>
<ci>k_45</ci>
<ci>k_52</ci>
<ci>k_65</ci>
</apply>
<apply>
<times />
<ci>k_12</ci>
<ci>k_34</ci>
<ci>k_45</ci>
<ci>k_52</ci>
<ci>k_65</ci>
</apply>
<apply>
<times />
<ci>k_16</ci>
<ci>k_32</ci>
<ci>k_45</ci>
<ci>k_52</ci>
<ci>k_65</ci>
</apply>
<apply>
<times />
<ci>k_12</ci>
<ci>k_32</ci>
<ci>k_45</ci>
<ci>k_52</ci>
<ci>k_65</ci>
</apply>
<apply>
<times />
<ci>k_16</ci>
<ci>k_32</ci>
<ci>k_43</ci>
<ci>k_52</ci>
<ci>k_65</ci>
</apply>
<apply>
<times />
<ci>k_12</ci>
<ci>k_32</ci>
<ci>k_43</ci>
<ci>k_52</ci>
<ci>k_65</ci>
</apply>
<apply>
<times />
<ci>k_12</ci>
<ci>k_34</ci>
<ci>k_45</ci>
<ci>k_56</ci>
<ci>k_61</ci>
</apply>
<apply>
<times />
<ci>k_12</ci>
<ci>k_32</ci>
<ci>k_45</ci>
<ci>k_56</ci>
<ci>k_61</ci>
</apply>
<apply>
<times />
<ci>k_12</ci>
<ci>k_32</ci>
<ci>k_43</ci>
<ci>k_56</ci>
<ci>k_61</ci>
</apply>
<apply>
<times />
<ci>k_12</ci>
<ci>k_32</ci>
<ci>k_43</ci>
<ci>k_54</ci>
<ci>k_61</ci>
</apply>
<apply>
<times />
<ci>k_12</ci>
<ci>k_34</ci>
<ci>k_45</ci>
<ci>k_52</ci>
<ci>k_61</ci>
</apply>
<apply>
<times />
<ci>k_12</ci>
<ci>k_32</ci>
<ci>k_45</ci>
<ci>k_52</ci>
<ci>k_61</ci>
</apply>
<apply>
<times />
<ci>k_12</ci>
<ci>k_32</ci>
<ci>k_43</ci>
<ci>k_52</ci>
<ci>k_61</ci>
</apply>
</apply>
</apply>
<apply>
<eq />
<ci>C3_sum</ci>
<apply>
<plus />
<apply>
<times />
<ci>k_16</ci>
<ci>k_25</ci>
<ci>k_43</ci>
<ci>k_54</ci>
<ci>k_65</ci>
</apply>
<apply>
<times />
<ci>k_12</ci>
<ci>k_25</ci>
<ci>k_43</ci>
<ci>k_54</ci>
<ci>k_65</ci>
</apply>
<apply>
<times />
<ci>k_16</ci>
<ci>k_23</ci>
<ci>k_43</ci>
<ci>k_54</ci>
<ci>k_65</ci>
</apply>
<apply>
<times />
<ci>k_12</ci>
<ci>k_23</ci>
<ci>k_43</ci>
<ci>k_54</ci>
<ci>k_65</ci>
</apply>
<apply>
<times />
<ci>k_16</ci>
<ci>k_21</ci>
<ci>k_43</ci>
<ci>k_54</ci>
<ci>k_65</ci>
</apply>
<apply>
<times />
<ci>k_16</ci>
<ci>k_23</ci>
<ci>k_45</ci>
<ci>k_52</ci>
<ci>k_65</ci>
</apply>
<apply>
<times />
<ci>k_12</ci>
<ci>k_23</ci>
<ci>k_45</ci>
<ci>k_52</ci>
<ci>k_65</ci>
</apply>
<apply>
<times />
<ci>k_16</ci>
<ci>k_23</ci>
<ci>k_43</ci>
<ci>k_52</ci>
<ci>k_65</ci>
</apply>
<apply>
<times />
<ci>k_12</ci>
<ci>k_23</ci>
<ci>k_43</ci>
<ci>k_52</ci>
<ci>k_65</ci>
</apply>
<apply>
<times />
<ci>k_12</ci>
<ci>k_23</ci>
<ci>k_45</ci>
<ci>k_56</ci>
<ci>k_61</ci>
</apply>
<apply>
<times />
<ci>k_12</ci>
<ci>k_23</ci>
<ci>k_43</ci>
<ci>k_56</ci>
<ci>k_61</ci>
</apply>
<apply>
<times />
<ci>k_12</ci>
<ci>k_25</ci>
<ci>k_43</ci>
<ci>k_54</ci>
<ci>k_61</ci>
</apply>
<apply>
<times />
<ci>k_12</ci>
<ci>k_23</ci>
<ci>k_43</ci>
<ci>k_54</ci>
<ci>k_61</ci>
</apply>
<apply>
<times />
<ci>k_12</ci>
<ci>k_23</ci>
<ci>k_45</ci>
<ci>k_52</ci>
<ci>k_61</ci>
</apply>
<apply>
<times />
<ci>k_12</ci>
<ci>k_23</ci>
<ci>k_43</ci>
<ci>k_52</ci>
<ci>k_61</ci>
</apply>
</apply>
</apply>
<apply>
<eq />
<ci>C4_sum</ci>
<apply>
<plus />
<apply>
<times />
<ci>k_16</ci>
<ci>k_25</ci>
<ci>k_34</ci>
<ci>k_54</ci>
<ci>k_65</ci>
</apply>
<apply>
<times />
<ci>k_12</ci>
<ci>k_25</ci>
<ci>k_34</ci>
<ci>k_54</ci>
<ci>k_65</ci>
</apply>
<apply>
<times />
<ci>k_16</ci>
<ci>k_23</ci>
<ci>k_34</ci>
<ci>k_54</ci>
<ci>k_65</ci>
</apply>
<apply>
<times />
<ci>k_12</ci>
<ci>k_23</ci>
<ci>k_34</ci>
<ci>k_54</ci>
<ci>k_65</ci>
</apply>
<apply>
<times />
<ci>k_16</ci>
<ci>k_21</ci>
<ci>k_34</ci>
<ci>k_54</ci>
<ci>k_65</ci>
</apply>
<apply>
<times />
<ci>k_16</ci>
<ci>k_25</ci>
<ci>k_32</ci>
<ci>k_54</ci>
<ci>k_65</ci>
</apply>
<apply>
<times />
<ci>k_12</ci>
<ci>k_25</ci>
<ci>k_32</ci>
<ci>k_54</ci>
<ci>k_65</ci>
</apply>
<apply>
<times />
<ci>k_16</ci>
<ci>k_21</ci>
<ci>k_32</ci>
<ci>k_54</ci>
<ci>k_65</ci>
</apply>
<apply>
<times />
<ci>k_16</ci>
<ci>k_23</ci>
<ci>k_34</ci>
<ci>k_52</ci>
<ci>k_65</ci>
</apply>
<apply>
<times />
<ci>k_12</ci>
<ci>k_23</ci>
<ci>k_34</ci>
<ci>k_52</ci>
<ci>k_65</ci>
</apply>
<apply>
<times />
<ci>k_12</ci>
<ci>k_23</ci>
<ci>k_34</ci>
<ci>k_56</ci>
<ci>k_61</ci>
</apply>
<apply>
<times />
<ci>k_12</ci>
<ci>k_25</ci>
<ci>k_34</ci>
<ci>k_54</ci>
<ci>k_61</ci>
</apply>
<apply>
<times />
<ci>k_12</ci>
<ci>k_23</ci>
<ci>k_34</ci>
<ci>k_54</ci>
<ci>k_61</ci>
</apply>
<apply>
<times />
<ci>k_12</ci>
<ci>k_25</ci>
<ci>k_32</ci>
<ci>k_54</ci>
<ci>k_61</ci>
</apply>
<apply>
<times />
<ci>k_12</ci>
<ci>k_23</ci>
<ci>k_34</ci>
<ci>k_52</ci>
<ci>k_61</ci>
</apply>
</apply>
</apply>
<apply>
<eq />
<ci>C5_sum</ci>
<apply>
<plus />
<apply>
<times />
<ci>k_16</ci>
<ci>k_25</ci>
<ci>k_34</ci>
<ci>k_45</ci>
<ci>k_65</ci>
</apply>
<apply>
<times />
<ci>k_12</ci>
<ci>k_25</ci>
<ci>k_34</ci>
<ci>k_45</ci>
<ci>k_65</ci>
</apply>
<apply>
<times />
<ci>k_16</ci>
<ci>k_23</ci>
<ci>k_34</ci>
<ci>k_45</ci>
<ci>k_65</ci>
</apply>
<apply>
<times />
<ci>k_12</ci>
<ci>k_23</ci>
<ci>k_34</ci>
<ci>k_45</ci>
<ci>k_65</ci>
</apply>
<apply>
<times />
<ci>k_16</ci>
<ci>k_21</ci>
<ci>k_34</ci>
<ci>k_45</ci>
<ci>k_65</ci>
</apply>
<apply>
<times />
<ci>k_16</ci>
<ci>k_25</ci>
<ci>k_32</ci>
<ci>k_45</ci>
<ci>k_65</ci>
</apply>
<apply>
<times />
<ci>k_12</ci>
<ci>k_25</ci>
<ci>k_32</ci>
<ci>k_45</ci>
<ci>k_65</ci>
</apply>
<apply>
<times />
<ci>k_16</ci>
<ci>k_21</ci>
<ci>k_32</ci>
<ci>k_45</ci>
<ci>k_65</ci>
</apply>
<apply>
<times />
<ci>k_16</ci>
<ci>k_25</ci>
<ci>k_32</ci>
<ci>k_43</ci>
<ci>k_65</ci>
</apply>
<apply>
<times />
<ci>k_12</ci>
<ci>k_25</ci>
<ci>k_32</ci>
<ci>k_43</ci>
<ci>k_65</ci>
</apply>
<apply>
<times />
<ci>k_16</ci>
<ci>k_21</ci>
<ci>k_32</ci>
<ci>k_43</ci>
<ci>k_65</ci>
</apply>
<apply>
<times />
<ci>k_12</ci>
<ci>k_25</ci>
<ci>k_34</ci>
<ci>k_45</ci>
<ci>k_61</ci>
</apply>
<apply>
<times />
<ci>k_12</ci>
<ci>k_23</ci>
<ci>k_34</ci>
<ci>k_45</ci>
<ci>k_61</ci>
</apply>
<apply>
<times />
<ci>k_12</ci>
<ci>k_25</ci>
<ci>k_32</ci>
<ci>k_45</ci>
<ci>k_61</ci>
</apply>
<apply>
<times />
<ci>k_12</ci>
<ci>k_25</ci>
<ci>k_32</ci>
<ci>k_43</ci>
<ci>k_61</ci>
</apply>
</apply>
</apply>
<apply>
<eq />
<ci>C6_sum</ci>
<apply>
<plus />
<apply>
<times />
<ci>k_16</ci>
<ci>k_25</ci>
<ci>k_34</ci>
<ci>k_45</ci>
<ci>k_56</ci>
</apply>
<apply>
<times />
<ci>k_12</ci>
<ci>k_25</ci>
<ci>k_34</ci>
<ci>k_45</ci>
<ci>k_56</ci>
</apply>
<apply>
<times />
<ci>k_16</ci>
<ci>k_23</ci>
<ci>k_34</ci>
<ci>k_45</ci>
<ci>k_56</ci>
</apply>
<apply>
<times />
<ci>k_12</ci>
<ci>k_23</ci>
<ci>k_34</ci>
<ci>k_45</ci>
<ci>k_56</ci>
</apply>
<apply>
<times />
<ci>k_16</ci>
<ci>k_21</ci>
<ci>k_34</ci>
<ci>k_45</ci>
<ci>k_56</ci>
</apply>
<apply>
<times />
<ci>k_16</ci>
<ci>k_25</ci>
<ci>k_32</ci>
<ci>k_45</ci>
<ci>k_56</ci>
</apply>
<apply>
<times />
<ci>k_12</ci>
<ci>k_25</ci>
<ci>k_32</ci>
<ci>k_45</ci>
<ci>k_56</ci>
</apply>
<apply>
<times />
<ci>k_16</ci>
<ci>k_21</ci>
<ci>k_32</ci>
<ci>k_45</ci>
<ci>k_56</ci>
</apply>
<apply>
<times />
<ci>k_16</ci>
<ci>k_25</ci>
<ci>k_32</ci>
<ci>k_43</ci>
<ci>k_56</ci>
</apply>
<apply>
<times />
<ci>k_12</ci>
<ci>k_25</ci>
<ci>k_32</ci>
<ci>k_43</ci>
<ci>k_56</ci>
</apply>
<apply>
<times />
<ci>k_16</ci>
<ci>k_21</ci>
<ci>k_32</ci>
<ci>k_43</ci>
<ci>k_56</ci>
</apply>
<apply>
<times />
<ci>k_16</ci>
<ci>k_21</ci>
<ci>k_32</ci>
<ci>k_43</ci>
<ci>k_54</ci>
</apply>
<apply>
<times />
<ci>k_16</ci>
<ci>k_21</ci>
<ci>k_34</ci>
<ci>k_45</ci>
<ci>k_52</ci>
</apply>
<apply>
<times />
<ci>k_16</ci>
<ci>k_21</ci>
<ci>k_32</ci>
<ci>k_45</ci>
<ci>k_52</ci>
</apply>
<apply>
<times />
<ci>k_16</ci>
<ci>k_21</ci>
<ci>k_32</ci>
<ci>k_43</ci>
<ci>k_52</ci>
</apply>
</apply>
</apply>
<apply>
<eq />
<ci>C_sum</ci>
<apply>
<plus />
<ci>C1_sum</ci>
<ci>C2_sum</ci>
<ci>C3_sum</ci>
<ci>C4_sum</ci>
<ci>C5_sum</ci>
<ci>C6_sum</ci>
</apply>
</apply>
<apply>
<eq />
<ci>C1</ci>
<apply>
<divide />
<apply>
<times />
<ci>C_T</ci>
<ci>C1_sum</ci>
</apply>
<ci>C_sum</ci>
</apply>
</apply>
<apply>
<eq />
<ci>C2</ci>
<apply>
<divide />
<apply>
<times />
<ci>C_T</ci>
<ci>C2_sum</ci>
</apply>
<ci>C_sum</ci>
</apply>
</apply>
<apply>
<eq />
<ci>C3</ci>
<apply>
<divide />
<apply>
<times />
<ci>C_T</ci>
<ci>C3_sum</ci>
</apply>
<ci>C_sum</ci>
</apply>
</apply>
<apply>
<eq />
<ci>C4</ci>
<apply>
<divide />
<apply>
<times />
<ci>C_T</ci>
<ci>C4_sum</ci>
</apply>
<ci>C_sum</ci>
</apply>
</apply>
<apply>
<eq />
<ci>C5</ci>
<apply>
<divide />
<apply>
<times />
<ci>C_T</ci>
<ci>C5_sum</ci>
</apply>
<ci>C_sum</ci>
</apply>
</apply>
<apply>
<eq />
<ci>C6</ci>
<apply>
<divide />
<apply>
<times />
<ci>C_T</ci>
<ci>C6_sum</ci>
</apply>
<ci>C_sum</ci>
</apply>
</apply>
</math>
</component>
<component name="NBC_current">
<variable cmeta:id="NBC_current.C_3" name="C_3" public_interface="in" units="umol" />
<variable cmeta:id="NBC_current.C_4" name="C_4" public_interface="in" units="umol" />
<variable cmeta:id="NBC_current.C_1" name="C_1" public_interface="in" units="umol" />
<variable cmeta:id="NBC_current.C_2" name="C_2" public_interface="in" units="umol" />
<variable cmeta:id="NBC_current.C_5" name="C_5" public_interface="in" units="umol" />
<variable cmeta:id="NBC_current.k_61" name="k_61" public_interface="in" units="per_second" />
<variable cmeta:id="NBC_current.C_6" name="C_6" public_interface="in" units="umol" />
<variable cmeta:id="NBC_current.k_21" name="k_21" public_interface="in" units="per_second" />
<variable cmeta:id="NBC_current.k_43" name="k_43" public_interface="in" units="per_second" />
<variable cmeta:id="NBC_current.k_65" name="k_65" public_interface="in" units="per_second" />
<variable cmeta:id="NBC_current.I_NaGl_SS" name="I_NaGl_SS" public_interface="out" units="uA" />
<variable cmeta:id="NBC_current.delta" name="delta" public_interface="in" units="dimensionless" />
<variable cmeta:id="NBC_current.k_25" name="k_25" public_interface="in" units="per_second" />
<variable cmeta:id="NBC_current.alpha_p" name="alpha_p" public_interface="in" units="dimensionless" />
<variable cmeta:id="NBC_current.n" name="n" public_interface="in" units="dimensionless" />
<variable cmeta:id="NBC_current.C6" name="C6" public_interface="in" units="umol" />
<variable cmeta:id="NBC_current.C5" name="C5" public_interface="in" units="umol" />
<variable cmeta:id="NBC_current.C4" name="C4" public_interface="in" units="umol" />
<variable cmeta:id="NBC_current.C3" name="C3" public_interface="in" units="umol" />
<variable cmeta:id="NBC_current.C2" name="C2" public_interface="in" units="umol" />
<variable cmeta:id="NBC_current.C1" name="C1" public_interface="in" units="umol" />
<variable cmeta:id="NBC_current.alpha_pp" name="alpha_pp" public_interface="in" units="dimensionless" />
<variable cmeta:id="NBC_current.k_52" name="k_52" public_interface="in" units="per_second" />
<variable cmeta:id="NBC_current.z_Na" name="z_Na" public_interface="in" units="dimensionless" />
<variable cmeta:id="NBC_current.k_12" name="k_12" public_interface="in" units="per_second" />
<variable cmeta:id="NBC_current.k_34" name="k_34" public_interface="in" units="per_second" />
<variable cmeta:id="NBC_current.k_56" name="k_56" public_interface="in" units="per_second" />
<variable cmeta:id="NBC_current.z_c" name="z_c" public_interface="in" units="dimensionless" />
<variable cmeta:id="NBC_current.k_16" name="k_16" public_interface="in" units="per_second" />
<variable cmeta:id="NBC_current.J_Na" name="J_Na" public_interface="out" units="umol_per_second" />
<variable cmeta:id="NBC_current.F" name="F" public_interface="in" units="C_per_mol" />
<variable cmeta:id="NBC_current.I_NaGl_pSS" name="I_NaGl_pSS" public_interface="out" units="uA" />
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq />
<ci>I_NaGl_pSS</ci>
<apply>
<times />
<apply>
<minus />
<ci>F</ci>
</apply>
<apply>
<plus />
<apply>
<times />
<ci>n</ci>
<ci>z_Na</ci>
<ci>alpha_p</ci>
<apply>
<minus />
<apply>
<times />
<ci>k_12</ci>
<ci>C_1</ci>
</apply>
<apply>
<times />
<ci>k_21</ci>
<ci>C_2</ci>
</apply>
</apply>
</apply>
<apply>
<times />
<ci>z_c</ci>
<ci>delta</ci>
<apply>
<minus />
<apply>
<times />
<ci>k_16</ci>
<ci>C_1</ci>
</apply>
<apply>
<times />
<ci>k_61</ci>
<ci>C_6</ci>
</apply>
</apply>
</apply>
<apply>
<times />
<ci>n</ci>
<ci>z_Na</ci>
<ci>alpha_pp</ci>
<apply>
<minus />
<apply>
<times />
<ci>k_56</ci>
<ci>C_5</ci>
</apply>
<apply>
<times />
<ci>k_65</ci>
<ci>C_6</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq />
<ci>I_NaGl_SS</ci>
<apply>
<times />
<apply>
<minus />
<ci>F</ci>
</apply>
<apply>
<plus />
<apply>
<times />
<ci>z_c</ci>
<apply>
<minus />
<apply>
<times />
<ci>k_16</ci>
<ci>C1</ci>
</apply>
<apply>
<times />
<ci>k_61</ci>
<ci>C6</ci>
</apply>
</apply>
</apply>
<apply>
<times />
<apply>
<plus />
<ci>z_c</ci>
<apply>
<times />
<ci>z_Na</ci>
<ci>n</ci>
</apply>
</apply>
<apply>
<minus />
<apply>
<times />
<ci>k_25</ci>
<ci>C2</ci>
</apply>
<apply>
<times />
<ci>k_52</ci>
<ci>C5</ci>
</apply>
</apply>
</apply>
<apply>
<times />
<apply>
<plus />
<ci>z_c</ci>
<apply>
<times />
<ci>z_Na</ci>
<ci>n</ci>
</apply>
</apply>
<apply>
<minus />
<apply>
<times />
<ci>k_34</ci>
<ci>C3</ci>
</apply>
<apply>
<times />
<ci>k_43</ci>
<ci>C4</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq />
<ci>J_Na</ci>
<apply>
<plus />
<apply>
<minus />
<apply>
<times />
<ci>k_25</ci>
<ci>C2</ci>
</apply>
<apply>
<times />
<ci>k_52</ci>
<ci>C5</ci>
</apply>
</apply>
<apply>
<minus />
<apply>
<times />
<ci>k_34</ci>
<ci>C3</ci>
</apply>
<apply>
<times />
<ci>k_43</ci>
<ci>C4</ci>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="rate_constants">
<variable cmeta:id="rate_constants.k0_32" name="k0_32" public_interface="in" units="per_second" />
<variable cmeta:id="rate_constants.k0_54" name="k0_54" public_interface="in" units="per_M_per_second" />
<variable cmeta:id="rate_constants.ks_12" name="ks_12" public_interface="out" units="per_M_per_second" />
<variable cmeta:id="rate_constants.alpha_pp" name="alpha_pp" public_interface="in" units="dimensionless" />
<variable cmeta:id="rate_constants.k0_52" name="k0_52" public_interface="in" units="per_second" />
<variable cmeta:id="rate_constants.glucose_o" name="glucose_o" public_interface="in" units="M" />
<variable cmeta:id="rate_constants.k0_12" name="k0_12" public_interface="in" units="per_M_per_second" />
<variable cmeta:id="rate_constants.k0_34" name="k0_34" public_interface="in" units="per_second" />
<variable cmeta:id="rate_constants.k0_56" name="k0_56" public_interface="in" units="per_second" />
<variable cmeta:id="rate_constants.z_c" name="z_c" public_interface="in" units="dimensionless" />
<variable cmeta:id="rate_constants.n" name="n" public_interface="in" units="dimensionless" />
<variable cmeta:id="rate_constants.k_32" name="k_32" public_interface="out" units="per_second" />
<variable cmeta:id="rate_constants.k_54" name="k_54" public_interface="out" units="per_second" />
<variable cmeta:id="rate_constants.z_Na" name="z_Na" public_interface="in" units="dimensionless" />
<variable cmeta:id="rate_constants.delta" name="delta" public_interface="in" units="dimensionless" />
<variable cmeta:id="rate_constants.k_12" name="k_12" public_interface="out" units="per_second" />
<variable cmeta:id="rate_constants.k_34" name="k_34" public_interface="out" units="per_second" />
<variable cmeta:id="rate_constants.k_56" name="k_56" public_interface="out" units="per_second" />
<variable cmeta:id="rate_constants.k_16" name="k_16" public_interface="out" units="per_second" />
<variable cmeta:id="rate_constants.Na_i" name="Na_i" public_interface="in" units="M" />
<variable cmeta:id="rate_constants.k_52" name="k_52" public_interface="out" units="per_second" />
<variable cmeta:id="rate_constants.k_52_temp" name="k_52_temp" public_interface="out" units="per_second" />
<variable cmeta:id="rate_constants.k0_54_temp" name="k0_54_temp" public_interface="out" units="per_M_per_second" />
<variable cmeta:id="rate_constants.k0_21" name="k0_21" public_interface="in" units="per_second" />
<variable cmeta:id="rate_constants.k0_43" name="k0_43" public_interface="in" units="per_second" />
<variable cmeta:id="rate_constants.k0_65" name="k0_65" public_interface="in" units="per_M_per_second" />
<variable cmeta:id="rate_constants.k0_25" name="k0_25" public_interface="in" units="per_second" />
<variable cmeta:id="rate_constants.k0_23" name="k0_23" public_interface="in" units="per_M_per_second" />
<variable cmeta:id="rate_constants.k0_45" name="k0_45" public_interface="in" units="per_second" />
<variable cmeta:id="rate_constants.k_21" name="k_21" public_interface="out" units="per_second" />
<variable cmeta:id="rate_constants.k_43" name="k_43" public_interface="out" units="per_second" />
<variable cmeta:id="rate_constants.k_65" name="k_65" public_interface="out" units="per_second" />
<variable cmeta:id="rate_constants.Na_o" name="Na_o" public_interface="in" units="M" />
<variable cmeta:id="rate_constants.k_23" name="k_23" public_interface="out" units="per_second" />
<variable cmeta:id="rate_constants.k_45" name="k_45" public_interface="out" units="per_second" />
<variable cmeta:id="rate_constants.k0_61" name="k0_61" public_interface="in" units="per_second" />
<variable cmeta:id="rate_constants.k_25" name="k_25" public_interface="out" units="per_second" />
<variable cmeta:id="rate_constants.mu" name="mu" public_interface="in" units="dimensionless" />
<variable cmeta:id="rate_constants.alpha_p" name="alpha_p" public_interface="in" units="dimensionless" />
<variable cmeta:id="rate_constants.k_61" name="k_61" public_interface="out" units="per_second" />
<variable cmeta:id="rate_constants.k0_16" name="k0_16" public_interface="in" units="per_second" />
<variable cmeta:id="rate_constants.C_T" name="C_T" public_interface="in" units="umol" />
<variable cmeta:id="rate_constants.glucose_i" name="glucose_i" public_interface="in" units="M" />
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq />
<ci>ks_12</ci>
<apply>
<times />
<ci>k0_12</ci>
<apply>
<exp />
<apply>
<divide />
<apply>
<times />
<apply>
<minus />
<ci>n</ci>
</apply>
<ci>alpha_p</ci>
<ci>mu</ci>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq />
<ci>k_12</ci>
<apply>
<times />
<ci>ks_12</ci>
<apply>
<power />
<ci>Na_o</ci>
<ci>n</ci>
</apply>
</apply>
</apply>
<apply>
<eq />
<ci>k_21</ci>
<apply>
<times />
<ci>k0_21</ci>
<apply>
<exp />
<apply>
<divide />
<apply>
<times />
<ci>n</ci>
<ci>z_Na</ci>
<ci>alpha_p</ci>
<ci>mu</ci>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq />
<ci>k_23</ci>
<apply>
<times />
<ci>k0_23</ci>
<ci>glucose_o</ci>
</apply>
</apply>
<apply>
<eq />
<ci>k_32</ci>
<ci>k0_32</ci>
</apply>
<apply>
<eq />
<ci>k_34</ci>
<apply>
<times />
<ci>k0_34</ci>
<apply>
<exp />
<apply>
<divide />
<apply>
<times />
<apply>
<minus />
<apply>
<plus />
<ci>z_c</ci>
<ci>n</ci>
</apply>
</apply>
<ci>delta</ci>
<ci>mu</ci>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq />
<ci>k_43</ci>
<apply>
<times />
<ci>k0_43</ci>
<apply>
<exp />
<apply>
<divide />
<apply>
<times />
<apply>
<plus />
<ci>z_c</ci>
<ci>n</ci>
</apply>
<ci>delta</ci>
<ci>mu</ci>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq />
<ci>k_45</ci>
<ci>k0_45</ci>
</apply>
<apply>
<eq />
<ci>k_54</ci>
<apply>
<times />
<ci>k0_54_temp</ci>
<ci>glucose_i</ci>
</apply>
</apply>
<apply>
<eq />
<ci>k_25</ci>
<apply>
<times />
<ci>k0_25</ci>
<apply>
<exp />
<apply>
<divide />
<apply>
<times />
<apply>
<minus />
<apply>
<plus />
<ci>z_c</ci>
<ci>n</ci>
</apply>
</apply>
<ci>delta</ci>
<ci>mu</ci>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq />
<ci>k_52_temp</ci>
<apply>
<times />
<ci>k0_52</ci>
<apply>
<exp />
<apply>
<divide />
<apply>
<times />
<apply>
<plus />
<ci>z_c</ci>
<ci>n</ci>
</apply>
<ci>delta</ci>
<ci>mu</ci>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq />
<ci>k_56</ci>
<apply>
<times />
<ci>k0_56</ci>
<apply>
<exp />
<apply>
<divide />
<apply>
<times />
<apply>
<minus />
<ci>n</ci>
</apply>
<ci>z_Na</ci>
<ci>alpha_pp</ci>
<ci>mu</ci>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq />
<ci>k_65</ci>
<apply>
<times />
<ci>k0_65</ci>
<apply>
<power />
<ci>Na_i</ci>
<ci>n</ci>
</apply>
<apply>
<exp />
<apply>
<divide />
<apply>
<times />
<ci>n</ci>
<ci>z_Na</ci>
<ci>alpha_pp</ci>
<ci>mu</ci>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq />
<ci>k_61</ci>
<apply>
<times />
<ci>k0_61</ci>
<apply>
<exp />
<apply>
<divide />
<apply>
<times />
<ci>z_c</ci>
<ci>delta</ci>
<ci>mu</ci>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq />
<ci>k_16</ci>
<apply>
<times />
<ci>k0_16</ci>
<apply>
<exp />
<apply>
<divide />
<apply>
<times />
<apply>
<minus />
<ci>z_c</ci>
</apply>
<ci>delta</ci>
<ci>mu</ci>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq />
<ci>k_52</ci>
<apply>
<divide />
<apply>
<times />
<ci>k0_12</ci>
<ci>k_25</ci>
<ci>k0_56</ci>
<ci>k0_61</ci>
</apply>
<apply>
<times />
<ci>k0_21</ci>
<ci>k0_16</ci>
<ci>k0_65</ci>
</apply>
</apply>
</apply>
<apply>
<eq />
<ci>k0_54_temp</ci>
<apply>
<divide />
<apply>
<times />
<ci>k0_23</ci>
<ci>k_34</ci>
<ci>k_45</ci>
<ci>k_52</ci>
</apply>
<apply>
<times />
<ci>k_43</ci>
<ci>k_32</ci>
<ci>k_25</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="phenomonological_constants">
<variable cmeta:id="phenomonological_constants.Khalf_Na" name="Khalf_Na" public_interface="out" units="M" />
<variable cmeta:id="phenomonological_constants.alpha" name="alpha" public_interface="out" units="M2" />
<variable cmeta:id="phenomonological_constants.F" name="F" public_interface="in" units="C_per_mol" />
<variable cmeta:id="phenomonological_constants.Imax_Na" name="Imax_Na" public_interface="out" units="uA" />
<variable cmeta:id="phenomonological_constants.gamma" name="gamma" public_interface="out" units="M2_per_second" />
<variable cmeta:id="phenomonological_constants.beta" name="beta" public_interface="out" units="M" />
<variable cmeta:id="phenomonological_constants.k_12" name="k_12" public_interface="in" units="per_second" />
<variable cmeta:id="phenomonological_constants.k_34" name="k_34" public_interface="in" units="per_second" />
<variable cmeta:id="phenomonological_constants.k_56" name="k_56" public_interface="in" units="per_second" />
<variable cmeta:id="phenomonological_constants.lambda" name="lambda" public_interface="out" units="per_M2_per_second5" />
<variable cmeta:id="phenomonological_constants.glucose_o" name="glucose_o" public_interface="in" units="M" />
<variable cmeta:id="phenomonological_constants.k_32" name="k_32" public_interface="in" units="per_second" />
<variable cmeta:id="phenomonological_constants.k_54" name="k_54" public_interface="in" units="per_second" />
<variable cmeta:id="phenomonological_constants.Na_o" name="Na_o" public_interface="in" units="M" />
<variable cmeta:id="phenomonological_constants.phi" name="phi" public_interface="out" units="M_per_second" />
<variable cmeta:id="phenomonological_constants.k_16" name="k_16" public_interface="in" units="per_second" />
<variable cmeta:id="phenomonological_constants.k0_23" name="k0_23" public_interface="in" units="per_M_per_second" />
<variable cmeta:id="phenomonological_constants.k_52" name="k_52" public_interface="in" units="per_second" />
<variable cmeta:id="phenomonological_constants.Khalf_gluc" name="Khalf_gluc" public_interface="out" units="M" />
<variable cmeta:id="phenomonological_constants.chi" name="chi" public_interface="out" units="M" />
<variable cmeta:id="phenomonological_constants.Imax_gluc" name="Imax_gluc" public_interface="out" units="uA" />
<variable cmeta:id="phenomonological_constants.C_T" name="C_T" public_interface="in" units="umol" />
<variable cmeta:id="phenomonological_constants.k_23" name="k_23" public_interface="in" units="per_second" />
<variable cmeta:id="phenomonological_constants.k_45" name="k_45" public_interface="in" units="per_second" />
<variable cmeta:id="phenomonological_constants.k_21" name="k_21" public_interface="in" units="per_second" />
<variable cmeta:id="phenomonological_constants.k_43" name="k_43" public_interface="in" units="per_second" />
<variable cmeta:id="phenomonological_constants.k_65" name="k_65" public_interface="in" units="per_second" />
<variable cmeta:id="phenomonological_constants.k_25" name="k_25" public_interface="in" units="per_second" />
<variable cmeta:id="phenomonological_constants.epsilon" name="epsilon" public_interface="out" units="per_second" />
<variable cmeta:id="phenomonological_constants.ks_12" name="ks_12" public_interface="in" units="per_M_per_second" />
<variable cmeta:id="phenomonological_constants.k_61" name="k_61" public_interface="in" units="per_second" />
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq />
<ci>lambda</ci>
<apply>
<plus />
<apply>
<times />
<ci>ks_12</ci>
<ci>k0_23</ci>
<ci>k_43</ci>
<ci>k_54</ci>
<ci>k_65</ci>
</apply>
<apply>
<times />
<ci>ks_12</ci>
<ci>k0_23</ci>
<ci>k_34</ci>
<ci>k_54</ci>
<ci>k_65</ci>
</apply>
<apply>
<times />
<ci>ks_12</ci>
<ci>k0_23</ci>
<ci>k_45</ci>
<ci>k_52</ci>
<ci>k_65</ci>
</apply>
<apply>
<times />
<ci>ks_12</ci>
<ci>k0_23</ci>
<ci>k_43</ci>
<ci>k_52</ci>
<ci>k_65</ci>
</apply>
<apply>
<times />
<ci>ks_12</ci>
<ci>k0_23</ci>
<ci>k_34</ci>
<ci>k_52</ci>
<ci>k_65</ci>
</apply>
<apply>
<times />
<ci>ks_12</ci>
<ci>k0_23</ci>
<ci>k_34</ci>
<ci>k_45</ci>
<ci>k_65</ci>
</apply>
<apply>
<times />
<ci>ks_12</ci>
<ci>k0_23</ci>
<ci>k_45</ci>
<ci>k_56</ci>
<ci>k_61</ci>
</apply>
<apply>
<times />
<ci>ks_12</ci>
<ci>k0_23</ci>
<ci>k_43</ci>
<ci>k_56</ci>
<ci>k_61</ci>
</apply>
<apply>
<times />
<ci>ks_12</ci>
<ci>k0_23</ci>
<ci>k_34</ci>
<ci>k_56</ci>
<ci>k_61</ci>
</apply>
<apply>
<times />
<ci>ks_12</ci>
<ci>k0_23</ci>
<ci>k_43</ci>
<ci>k_54</ci>
<ci>k_61</ci>
</apply>
<apply>
<times />
<ci>ks_12</ci>
<ci>k0_23</ci>
<ci>k_34</ci>
<ci>k_54</ci>
<ci>k_61</ci>
</apply>
<apply>
<times />
<ci>ks_12</ci>
<ci>k0_23</ci>
<ci>k_45</ci>
<ci>k_52</ci>
<ci>k_61</ci>
</apply>
<apply>
<times />
<ci>ks_12</ci>
<ci>k0_23</ci>
<ci>k_43</ci>
<ci>k_52</ci>
<ci>k_61</ci>
</apply>
<apply>
<times />
<ci>ks_12</ci>
<ci>k0_23</ci>
<ci>k_34</ci>
<ci>k_52</ci>
<ci>k_61</ci>
</apply>
<apply>
<times />
<ci>ks_12</ci>
<ci>k0_23</ci>
<ci>k_34</ci>
<ci>k_45</ci>
<ci>k_61</ci>
</apply>
<apply>
<times />
<ci>ks_12</ci>
<ci>k0_23</ci>
<ci>k_34</ci>
<ci>k_45</ci>
<ci>k_56</ci>
</apply>
</apply>
</apply>
<apply>
<eq />
<ci>chi</ci>
<apply>
<times />
<apply>
<divide />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<ci>lambda</ci>
</apply>
<apply>
<plus />
<apply>
<times />
<ci>ks_12</ci>
<ci>k_32</ci>
<ci>k_43</ci>
<ci>k_54</ci>
<ci>k_65</ci>
</apply>
<apply>
<times />
<ci>ks_12</ci>
<ci>k_25</ci>
<ci>k_43</ci>
<ci>k_54</ci>
<ci>k_65</ci>
</apply>
<apply>
<times />
<ci>ks_12</ci>
<ci>k_25</ci>
<ci>k_34</ci>
<ci>k_54</ci>
<ci>k_65</ci>
</apply>
<apply>
<times />
<ci>ks_12</ci>
<ci>k_25</ci>
<ci>k_32</ci>
<ci>k_54</ci>
<ci>k_65</ci>
</apply>
<apply>
<times />
<ci>ks_12</ci>
<ci>k_34</ci>
<ci>k_45</ci>
<ci>k_52</ci>
<ci>k_65</ci>
</apply>
<apply>
<times />
<ci>ks_12</ci>
<ci>k_32</ci>
<ci>k_45</ci>
<ci>k_52</ci>
<ci>k_65</ci>
</apply>
<apply>
<times />
<ci>ks_12</ci>
<ci>k_32</ci>
<ci>k_43</ci>
<ci>k_52</ci>
<ci>k_65</ci>
</apply>
<apply>
<times />
<ci>ks_12</ci>
<ci>k_25</ci>
<ci>k_34</ci>
<ci>k_45</ci>
<ci>k_65</ci>
</apply>
<apply>
<times />
<ci>ks_12</ci>
<ci>k_25</ci>
<ci>k_32</ci>
<ci>k_45</ci>
<ci>k_65</ci>
</apply>
<apply>
<times />
<ci>ks_12</ci>
<ci>k_25</ci>
<ci>k_32</ci>
<ci>k_43</ci>
<ci>k_65</ci>
</apply>
<apply>
<times />
<ci>ks_12</ci>
<ci>k_34</ci>
<ci>k_45</ci>
<ci>k_56</ci>
<ci>k_61</ci>
</apply>
<apply>
<times />
<ci>ks_12</ci>
<ci>k_32</ci>
<ci>k_45</ci>
<ci>k_56</ci>
<ci>k_61</ci>
</apply>
<apply>
<times />
<ci>ks_12</ci>
<ci>k_32</ci>
<ci>k_43</ci>
<ci>k_56</ci>
<ci>k_61</ci>
</apply>
<apply>
<times />
<ci>ks_12</ci>
<ci>k_32</ci>
<ci>k_43</ci>
<ci>k_54</ci>
<ci>k_61</ci>
</apply>
<apply>
<times />
<ci>ks_12</ci>
<ci>k_25</ci>
<ci>k_43</ci>
<ci>k_54</ci>
<ci>k_61</ci>
</apply>
<apply>
<times />
<ci>ks_12</ci>
<ci>k_25</ci>
<ci>k_34</ci>
<ci>k_54</ci>
<ci>k_61</ci>
</apply>
<apply>
<times />
<ci>ks_12</ci>
<ci>k_25</ci>
<ci>k_32</ci>
<ci>k_54</ci>
<ci>k_61</ci>
</apply>
<apply>
<times />
<ci>ks_12</ci>
<ci>k_34</ci>
<ci>k_45</ci>
<ci>k_52</ci>
<ci>k_61</ci>
</apply>
<apply>
<times />
<ci>ks_12</ci>
<ci>k_32</ci>
<ci>k_45</ci>
<ci>k_52</ci>
<ci>k_61</ci>
</apply>
<apply>
<times />
<ci>ks_12</ci>
<ci>k_32</ci>
<ci>k_43</ci>
<ci>k_52</ci>
<ci>k_61</ci>
</apply>
<apply>
<times />
<ci>ks_12</ci>
<ci>k_25</ci>
<ci>k_34</ci>
<ci>k_45</ci>
<ci>k_61</ci>
</apply>
<apply>
<times />
<ci>ks_12</ci>
<ci>k_25</ci>
<ci>k_32</ci>
<ci>k_45</ci>
<ci>k_61</ci>
</apply>
<apply>
<times />
<ci>ks_12</ci>
<ci>k_25</ci>
<ci>k_32</ci>
<ci>k_43</ci>
<ci>k_61</ci>
</apply>
<apply>
<times />
<ci>ks_12</ci>
<ci>k_25</ci>
<ci>k_34</ci>
<ci>k_45</ci>
<ci>k_56</ci>
</apply>
<apply>
<times />
<ci>ks_12</ci>
<ci>k_25</ci>
<ci>k_32</ci>
<ci>k_45</ci>
<ci>k_56</ci>
</apply>
<apply>
<times />
<ci>ks_12</ci>
<ci>k_25</ci>
<ci>k_32</ci>
<ci>k_43</ci>
<ci>k_56</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq />
<ci>beta</ci>
<apply>
<times />
<apply>
<divide />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<ci>lambda</ci>
</apply>
<apply>
<plus />
<apply>
<times />
<ci>k0_23</ci>
<ci>k_16</ci>
<ci>k_43</ci>
<ci>k_54</ci>
<ci>k_65</ci>
</apply>
<apply>
<times />
<ci>k0_23</ci>
<ci>k_16</ci>
<ci>k_34</ci>
<ci>k_54</ci>
<ci>k_65</ci>
</apply>
<apply>
<times />
<ci>k0_23</ci>
<ci>k_16</ci>
<ci>k_45</ci>
<ci>k_52</ci>
<ci>k_65</ci>
</apply>
<apply>
<times />
<ci>k0_23</ci>
<ci>k_16</ci>
<ci>k_43</ci>
<ci>k_52</ci>
<ci>k_65</ci>
</apply>
<apply>
<times />
<ci>k0_23</ci>
<ci>k_16</ci>
<ci>k_34</ci>
<ci>k_52</ci>
<ci>k_65</ci>
</apply>
<apply>
<times />
<ci>k0_23</ci>
<ci>k_16</ci>
<ci>k_34</ci>
<ci>k_45</ci>
<ci>k_65</ci>
</apply>
<apply>
<times />
<ci>k0_23</ci>
<ci>k_34</ci>
<ci>k_45</ci>
<ci>k_56</ci>
<ci>k_61</ci>
</apply>
<apply>
<times />
<ci>k0_23</ci>
<ci>k_16</ci>
<ci>k_34</ci>
<ci>k_45</ci>
<ci>k_56</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq />
<ci>alpha</ci>
<apply>
<times />
<apply>
<divide />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<ci>lambda</ci>
</apply>
<apply>
<plus />
<apply>
<times />
<ci>k_21</ci>
<ci>k_32</ci>
<ci>k_43</ci>
<ci>k_54</ci>
<ci>k_65</ci>
</apply>
<apply>
<times />
<ci>k_16</ci>
<ci>k_32</ci>
<ci>k_43</ci>
<ci>k_54</ci>
<ci>k_65</ci>
</apply>
<apply>
<times />
<ci>k_16</ci>
<ci>k_25</ci>
<ci>k_43</ci>
<ci>k_54</ci>
<ci>k_65</ci>
</apply>
<apply>
<times />
<ci>k_16</ci>
<ci>k_21</ci>
<ci>k_43</ci>
<ci>k_54</ci>
<ci>k_65</ci>
</apply>
<apply>
<times />
<ci>k_16</ci>
<ci>k_25</ci>
<ci>k_34</ci>
<ci>k_54</ci>
<ci>k_65</ci>
</apply>
<apply>
<times />
<ci>k_16</ci>
<ci>k_21</ci>
<ci>k_34</ci>
<ci>k_54</ci>
<ci>k_65</ci>
</apply>
<apply>
<times />
<ci>k_16</ci>
<ci>k_25</ci>
<ci>k_32</ci>
<ci>k_54</ci>
<ci>k_65</ci>
</apply>
<apply>
<times />
<ci>k_16</ci>
<ci>k_21</ci>
<ci>k_32</ci>
<ci>k_54</ci>
<ci>k_65</ci>
</apply>
<apply>
<times />
<ci>k_21</ci>
<ci>k_34</ci>
<ci>k_45</ci>
<ci>k_52</ci>
<ci>k_65</ci>
</apply>
<apply>
<times />
<ci>k_16</ci>
<ci>k_34</ci>
<ci>k_45</ci>
<ci>k_52</ci>
<ci>k_65</ci>
</apply>
<apply>
<times />
<ci>k_21</ci>
<ci>k_32</ci>
<ci>k_45</ci>
<ci>k_52</ci>
<ci>k_65</ci>
</apply>
<apply>
<times />
<ci>k_16</ci>
<ci>k_32</ci>
<ci>k_45</ci>
<ci>k_52</ci>
<ci>k_65</ci>
</apply>
<apply>
<times />
<ci>k_21</ci>
<ci>k_32</ci>
<ci>k_43</ci>
<ci>k_52</ci>
<ci>k_65</ci>
</apply>
<apply>
<times />
<ci>k_16</ci>
<ci>k_32</ci>
<ci>k_43</ci>
<ci>k_52</ci>
<ci>k_65</ci>
</apply>
<apply>
<times />
<ci>k_16</ci>
<ci>k_25</ci>
<ci>k_34</ci>
<ci>k_45</ci>
<ci>k_65</ci>
</apply>
<apply>
<times />
<ci>k_16</ci>
<ci>k_21</ci>
<ci>k_34</ci>
<ci>k_45</ci>
<ci>k_65</ci>
</apply>
<apply>
<times />
<ci>k_16</ci>
<ci>k_25</ci>
<ci>k_32</ci>
<ci>k_45</ci>
<ci>k_65</ci>
</apply>
<apply>
<times />
<ci>k_16</ci>
<ci>k_21</ci>
<ci>k_32</ci>
<ci>k_45</ci>
<ci>k_65</ci>
</apply>
<apply>
<times />
<ci>k_16</ci>
<ci>k_25</ci>
<ci>k_32</ci>
<ci>k_43</ci>
<ci>k_65</ci>
</apply>
<apply>
<times />
<ci>k_16</ci>
<ci>k_21</ci>
<ci>k_32</ci>
<ci>k_43</ci>
<ci>k_65</ci>
</apply>
<apply>
<times />
<ci>k_25</ci>
<ci>k_34</ci>
<ci>k_45</ci>
<ci>k_56</ci>
<ci>k_61</ci>
</apply>
<apply>
<times />
<ci>k_21</ci>
<ci>k_34</ci>
<ci>k_45</ci>
<ci>k_56</ci>
<ci>k_61</ci>
</apply>
<apply>
<times />
<ci>k_25</ci>
<ci>k_32</ci>
<ci>k_45</ci>
<ci>k_56</ci>
<ci>k_61</ci>
</apply>
<apply>
<times />
<ci>k_21</ci>
<ci>k_32</ci>
<ci>k_45</ci>
<ci>k_56</ci>
<ci>k_61</ci>
</apply>
<apply>
<times />
<ci>k_25</ci>
<ci>k_32</ci>
<ci>k_43</ci>
<ci>k_56</ci>
<ci>k_61</ci>
</apply>
<apply>
<times />
<ci>k_21</ci>
<ci>k_32</ci>
<ci>k_43</ci>
<ci>k_56</ci>
<ci>k_61</ci>
</apply>
<apply>
<times />
<ci>k_21</ci>
<ci>k_32</ci>
<ci>k_43</ci>
<ci>k_54</ci>
<ci>k_61</ci>
</apply>
<apply>
<times />
<ci>k_21</ci>
<ci>k_34</ci>
<ci>k_45</ci>
<ci>k_52</ci>
<ci>k_61</ci>
</apply>
<apply>
<times />
<ci>k_21</ci>
<ci>k_32</ci>
<ci>k_45</ci>
<ci>k_52</ci>
<ci>k_61</ci>
</apply>
<apply>
<times />
<ci>k_21</ci>
<ci>k_32</ci>
<ci>k_43</ci>
<ci>k_52</ci>
<ci>k_61</ci>
</apply>
<apply>
<times />
<ci>k_16</ci>
<ci>k_25</ci>
<ci>k_34</ci>
<ci>k_45</ci>
<ci>k_56</ci>
</apply>
<apply>
<times />
<ci>k_16</ci>
<ci>k_21</ci>
<ci>k_34</ci>
<ci>k_45</ci>
<ci>k_56</ci>
</apply>
<apply>
<times />
<ci>k_16</ci>
<ci>k_25</ci>
<ci>k_32</ci>
<ci>k_45</ci>
<ci>k_56</ci>
</apply>
<apply>
<times />
<ci>k_16</ci>
<ci>k_21</ci>
<ci>k_32</ci>
<ci>k_45</ci>
<ci>k_56</ci>
</apply>
<apply>
<times />
<ci>k_16</ci>
<ci>k_25</ci>
<ci>k_32</ci>
<ci>k_43</ci>
<ci>k_56</ci>
</apply>
<apply>
<times />
<ci>k_16</ci>
<ci>k_21</ci>
<ci>k_32</ci>
<ci>k_43</ci>
<ci>k_56</ci>
</apply>
<apply>
<times />
<ci>k_16</ci>
<ci>k_21</ci>
<ci>k_32</ci>
<ci>k_43</ci>
<ci>k_54</ci>
</apply>
<apply>
<times />
<ci>k_16</ci>
<ci>k_21</ci>
<ci>k_34</ci>
<ci>k_45</ci>
<ci>k_52</ci>
</apply>
<apply>
<times />
<ci>k_16</ci>
<ci>k_21</ci>
<ci>k_32</ci>
<ci>k_45</ci>
<ci>k_52</ci>
</apply>
<apply>
<times />
<ci>k_16</ci>
<ci>k_21</ci>
<ci>k_32</ci>
<ci>k_43</ci>
<ci>k_52</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq />
<ci>gamma</ci>
<apply>
<times />
<apply>
<divide />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<ci>lambda</ci>
</apply>
<apply>
<plus />
<apply>
<times />
<ci>k_16</ci>
<ci>k_21</ci>
<ci>k_32</ci>
<ci>k_43</ci>
<ci>k_54</ci>
<ci>k_65</ci>
</apply>
<apply>
<times />
<ci>k_16</ci>
<ci>k_21</ci>
<ci>k_34</ci>
<ci>k_45</ci>
<ci>k_52</ci>
<ci>k_65</ci>
</apply>
<apply>
<times />
<ci>k_16</ci>
<ci>k_21</ci>
<ci>k_32</ci>
<ci>k_45</ci>
<ci>k_52</ci>
<ci>k_65</ci>
</apply>
<apply>
<times />
<ci>k_16</ci>
<ci>k_21</ci>
<ci>k_32</ci>
<ci>k_43</ci>
<ci>k_52</ci>
<ci>k_65</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq />
<ci>phi</ci>
<apply>
<times />
<apply>
<divide />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<ci>lambda</ci>
</apply>
<apply>
<minus />
<apply>
<minus />
<apply>
<times />
<apply>
<minus />
<ci>ks_12</ci>
</apply>
<ci>k_25</ci>
<ci>k_34</ci>
<ci>k_45</ci>
<ci>k_56</ci>
<ci>k_61</ci>
</apply>
<apply>
<times />
<ci>ks_12</ci>
<ci>k_25</ci>
<ci>k_32</ci>
<ci>k_45</ci>
<ci>k_56</ci>
<ci>k_61</ci>
</apply>
</apply>
<apply>
<times />
<ci>ks_12</ci>
<ci>k_25</ci>
<ci>k_32</ci>
<ci>k_43</ci>
<ci>k_56</ci>
<ci>k_61</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq />
<ci>epsilon</ci>
<apply>
<times />
<apply>
<divide />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<ci>lambda</ci>
</apply>
<apply>
<minus />
<ci>ks_12</ci>
</apply>
<ci>k0_23</ci>
<ci>k_34</ci>
<ci>k_45</ci>
<ci>k_56</ci>
<ci>k_61</ci>
</apply>
</apply>
<apply>
<eq />
<ci>Imax_gluc</ci>
<apply>
<divide />
<apply>
<times />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
<ci>F</ci>
<ci>C_T</ci>
<ci>epsilon</ci>
<ci>Na_o</ci>
</apply>
<apply>
<plus />
<ci>beta</ci>
<ci>Na_o</ci>
</apply>
</apply>
</apply>
<apply>
<eq />
<ci>Imax_Na</ci>
<apply>
<divide />
<apply>
<times />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
<ci>F</ci>
<ci>C_T</ci>
<apply>
<plus />
<ci>phi</ci>
<apply>
<times />
<ci>epsilon</ci>
<ci>glucose_o</ci>
</apply>
</apply>
</apply>
<apply>
<plus />
<ci>chi</ci>
<ci>glucose_o</ci>
</apply>
</apply>
</apply>
<apply>
<eq />
<ci>Khalf_gluc</ci>
<apply>
<divide />
<apply>
<plus />
<ci>alpha</ci>
<apply>
<times />
<ci>chi</ci>
<ci>Na_o</ci>
</apply>
</apply>
<apply>
<plus />
<ci>beta</ci>
<ci>Na_o</ci>
</apply>
</apply>
</apply>
<apply>
<eq />
<ci>Khalf_Na</ci>
<apply>
<divide />
<apply>
<plus />
<ci>alpha</ci>
<apply>
<times />
<ci>beta</ci>
<ci>glucose_o</ci>
</apply>
</apply>
<apply>
<plus />
<ci>chi</ci>
<ci>glucose_o</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="kinetic_equations">
<variable cmeta:id="kinetic_equations.time" name="time" public_interface="in" units="second" />
<variable cmeta:id="kinetic_equations.C_6_temp" name="C_6_temp" public_interface="out" units="umol" />
<variable cmeta:id="kinetic_equations.k_52" name="k_52" public_interface="in" units="per_second" />
<variable cmeta:id="kinetic_equations.k_61" name="k_61" public_interface="in" units="per_second" />
<variable cmeta:id="kinetic_equations.k_16" name="k_16" public_interface="in" units="per_second" />
<variable cmeta:id="kinetic_equations.k_25" name="k_25" public_interface="in" units="per_second" />
<variable cmeta:id="kinetic_equations.k_12" name="k_12" public_interface="in" units="per_second" />
<variable cmeta:id="kinetic_equations.k_23" name="k_23" public_interface="in" units="per_second" />
<variable cmeta:id="kinetic_equations.k_34" name="k_34" public_interface="in" units="per_second" />
<variable cmeta:id="kinetic_equations.k_45" name="k_45" public_interface="in" units="per_second" />
<variable cmeta:id="kinetic_equations.k_56" name="k_56" public_interface="in" units="per_second" />
<variable cmeta:id="kinetic_equations.k_21" name="k_21" public_interface="in" units="per_second" />
<variable cmeta:id="kinetic_equations.k_32" name="k_32" public_interface="in" units="per_second" />
<variable cmeta:id="kinetic_equations.k_43" name="k_43" public_interface="in" units="per_second" />
<variable cmeta:id="kinetic_equations.k_54" name="k_54" public_interface="in" units="per_second" />
<variable cmeta:id="kinetic_equations.k_65" name="k_65" public_interface="in" units="per_second" />
<variable cmeta:id="kinetic_equations.C_6" name="C_6" public_interface="out" units="umol" />
<variable cmeta:id="kinetic_equations.C_5" name="C_5" public_interface="out" units="umol" />
<variable cmeta:id="kinetic_equations.C_4" name="C_4" public_interface="out" units="umol" />
<variable cmeta:id="kinetic_equations.C_T" name="C_T" public_interface="in" units="umol" />
<variable cmeta:id="kinetic_equations.C_3" name="C_3" public_interface="out" units="umol" />
<variable cmeta:id="kinetic_equations.C_2" name="C_2" public_interface="out" units="umol" />
<variable cmeta:id="kinetic_equations.C_1" name="C_1" public_interface="out" units="umol" />
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq />
<apply>
<diff />
<bvar>
<ci>time</ci>
</bvar>
<ci>C_1</ci>
</apply>
<apply>
<minus />
<apply>
<plus />
<apply>
<times />
<ci>k_21</ci>
<ci>C_2</ci>
</apply>
<apply>
<times />
<ci>k_61</ci>
<ci>C_6</ci>
</apply>
</apply>
<apply>
<times />
<apply>
<plus />
<ci>k_12</ci>
<ci>k_16</ci>
</apply>
<ci>C_1</ci>
</apply>
</apply>
</apply>
<apply>
<eq />
<apply>
<diff />
<bvar>
<ci>time</ci>
</bvar>
<ci>C_2</ci>
</apply>
<apply>
<minus />
<apply>
<plus />
<apply>
<times />
<ci>k_12</ci>
<ci>C_1</ci>
</apply>
<apply>
<times />
<ci>k_32</ci>
<ci>C_3</ci>
</apply>
<apply>
<times />
<ci>k_52</ci>
<ci>C_5</ci>
</apply>
</apply>
<apply>
<times />
<apply>
<plus />
<ci>k_21</ci>
<ci>k_23</ci>
<ci>k_25</ci>
</apply>
<ci>C_2</ci>
</apply>
</apply>
</apply>
<apply>
<eq />
<apply>
<diff />
<bvar>
<ci>time</ci>
</bvar>
<ci>C_3</ci>
</apply>
<apply>
<minus />
<apply>
<plus />
<apply>
<times />
<ci>k_23</ci>
<ci>C_2</ci>
</apply>
<apply>
<times />
<ci>k_43</ci>
<ci>C_4</ci>
</apply>
</apply>
<apply>
<times />
<apply>
<plus />
<ci>k_32</ci>
<ci>k_34</ci>
</apply>
<ci>C_3</ci>
</apply>
</apply>
</apply>
<apply>
<eq />
<apply>
<diff />
<bvar>
<ci>time</ci>
</bvar>
<ci>C_4</ci>
</apply>
<apply>
<minus />
<apply>
<plus />
<apply>
<times />
<ci>k_34</ci>
<ci>C_3</ci>
</apply>
<apply>
<times />
<ci>k_54</ci>
<ci>C_5</ci>
</apply>
</apply>
<apply>
<times />
<apply>
<plus />
<ci>k_45</ci>
<ci>k_43</ci>
</apply>
<ci>C_4</ci>
</apply>
</apply>
</apply>
<apply>
<eq />
<apply>
<diff />
<bvar>
<ci>time</ci>
</bvar>
<ci>C_5</ci>
</apply>
<apply>
<minus />
<apply>
<plus />
<apply>
<times />
<ci>k_45</ci>
<ci>C_4</ci>
</apply>
<apply>
<times />
<ci>k_65</ci>
<ci>C_6</ci>
</apply>
<apply>
<times />
<ci>k_25</ci>
<ci>C_2</ci>
</apply>
</apply>
<apply>
<times />
<apply>
<plus />
<ci>k_54</ci>
<ci>k_52</ci>
<ci>k_56</ci>
</apply>
<ci>C_5</ci>
</apply>
</apply>
</apply>
<apply>
<eq />
<apply>
<diff />
<bvar>
<ci>time</ci>
</bvar>
<ci>C_6_temp</ci>
</apply>
<apply>
<minus />
<apply>
<plus />
<apply>
<times />
<ci>k_16</ci>
<ci>C_1</ci>
</apply>
<apply>
<times />
<ci>k_56</ci>
<ci>C_5</ci>
</apply>
</apply>
<apply>
<times />
<apply>
<plus />
<ci>k_61</ci>
<ci>k_65</ci>
</apply>
<ci>C_6_temp</ci>
</apply>
</apply>
</apply>
<apply>
<eq />
<ci>C_6</ci>
<apply>
<minus />
<ci>C_T</ci>
<apply>
<plus />
<ci>C_1</ci>
<ci>C_2</ci>
<ci>C_3</ci>
<ci>C_4</ci>
<ci>C_5</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="environment">
<variable cmeta:id="environment.time" name="time" public_interface="out" units="second" />
</component>
<component name="ion_concentrations">
<variable cmeta:id="ion_concentrations.glucose_i" name="glucose_i" public_interface="out" units="M" />
<variable cmeta:id="ion_concentrations.Na_o" name="Na_o" public_interface="out" units="M" />
<variable cmeta:id="ion_concentrations.V" name="V" public_interface="out" units="volt" />
<variable cmeta:id="ion_concentrations.time" name="time" public_interface="in" units="second" />
<variable cmeta:id="ion_concentrations.glucose_o" name="glucose_o" public_interface="out" units="M" />
<variable cmeta:id="ion_concentrations.Na_i" name="Na_i" public_interface="out" units="M" />
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq />
<apply>
<diff />
<bvar>
<ci>time</ci>
</bvar>
<ci>V</ci>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" type="e-notation" cellml:units="volt_per_second">
100
<sep />
-6
</cn>
</apply>
</math>
</component>
<connection>
<map_components component_1="rate_constants" component_2="king_altman_states" />
<map_variables variable_1="k_43" variable_2="k_43" />
<map_variables variable_1="k_56" variable_2="k_56" />
<map_variables variable_1="k_23" variable_2="k_23" />
<map_variables variable_1="k_25" variable_2="k_25" />
<map_variables variable_1="k_21" variable_2="k_21" />
<map_variables variable_1="k_45" variable_2="k_45" />
<map_variables variable_1="k_52" variable_2="k_52" />
<map_variables variable_1="k_61" variable_2="k_61" />
<map_variables variable_1="k_32" variable_2="k_32" />
<map_variables variable_1="k_54" variable_2="k_54" />
<map_variables variable_1="k_34" variable_2="k_34" />
<map_variables variable_1="k_16" variable_2="k_16" />
<map_variables variable_1="k_12" variable_2="k_12" />
<map_variables variable_1="k_65" variable_2="k_65" />
</connection>
<connection>
<map_components component_1="rate_constants" component_2="kinetic_equations" />
<map_variables variable_1="k_43" variable_2="k_43" />
<map_variables variable_1="k_56" variable_2="k_56" />
<map_variables variable_1="k_23" variable_2="k_23" />
<map_variables variable_1="k_25" variable_2="k_25" />
<map_variables variable_1="k_21" variable_2="k_21" />
<map_variables variable_1="k_45" variable_2="k_45" />
<map_variables variable_1="k_52" variable_2="k_52" />
<map_variables variable_1="k_61" variable_2="k_61" />
<map_variables variable_1="k_32" variable_2="k_32" />
<map_variables variable_1="k_54" variable_2="k_54" />
<map_variables variable_1="k_34" variable_2="k_34" />
<map_variables variable_1="k_16" variable_2="k_16" />
<map_variables variable_1="k_12" variable_2="k_12" />
<map_variables variable_1="k_65" variable_2="k_65" />
</connection>
<connection>
<map_components component_1="kinetic_equations" component_2="NBC_current" />
<map_variables variable_1="C_4" variable_2="C_4" />
<map_variables variable_1="C_2" variable_2="C_2" />
<map_variables variable_1="C_5" variable_2="C_5" />
<map_variables variable_1="C_1" variable_2="C_1" />
<map_variables variable_1="C_3" variable_2="C_3" />
<map_variables variable_1="C_6" variable_2="C_6" />
</connection>
<connection>
<map_components component_1="environment" component_2="kinetic_equations" />
<map_variables variable_1="time" variable_2="time" />
</connection>
<connection>
<map_components component_1="king_altman_states" component_2="NBC_current" />
<map_variables variable_1="C4" variable_2="C4" />
<map_variables variable_1="C6" variable_2="C6" />
<map_variables variable_1="C5" variable_2="C5" />
<map_variables variable_1="C3" variable_2="C3" />
<map_variables variable_1="C2" variable_2="C2" />
<map_variables variable_1="C1" variable_2="C1" />
</connection>
<connection>
<map_components component_1="rate_constants" component_2="phenomonological_constants" />
<map_variables variable_1="k_43" variable_2="k_43" />
<map_variables variable_1="k_56" variable_2="k_56" />
<map_variables variable_1="k_23" variable_2="k_23" />
<map_variables variable_1="k_25" variable_2="k_25" />
<map_variables variable_1="k_21" variable_2="k_21" />
<map_variables variable_1="k_45" variable_2="k_45" />
<map_variables variable_1="k_52" variable_2="k_52" />
<map_variables variable_1="k_61" variable_2="k_61" />
<map_variables variable_1="k_32" variable_2="k_32" />
<map_variables variable_1="k_54" variable_2="k_54" />
<map_variables variable_1="ks_12" variable_2="ks_12" />
<map_variables variable_1="k_34" variable_2="k_34" />
<map_variables variable_1="k_16" variable_2="k_16" />
<map_variables variable_1="k_12" variable_2="k_12" />
<map_variables variable_1="k_65" variable_2="k_65" />
</connection>
<connection>
<map_components component_1="rate_constants" component_2="NBC_current" />
<map_variables variable_1="k_43" variable_2="k_43" />
<map_variables variable_1="k_56" variable_2="k_56" />
<map_variables variable_1="k_25" variable_2="k_25" />
<map_variables variable_1="k_34" variable_2="k_34" />
<map_variables variable_1="k_16" variable_2="k_16" />
<map_variables variable_1="k_21" variable_2="k_21" />
<map_variables variable_1="k_12" variable_2="k_12" />
<map_variables variable_1="k_52" variable_2="k_52" />
<map_variables variable_1="k_61" variable_2="k_61" />
<map_variables variable_1="k_65" variable_2="k_65" />
</connection>
<connection>
<map_components component_1="parameters" component_2="king_altman_states" />
<map_variables variable_1="C_T" variable_2="C_T" />
</connection>
<connection>
<map_components component_1="parameters" component_2="phenomonological_constants" />
<map_variables variable_1="C_T" variable_2="C_T" />
<map_variables variable_1="F" variable_2="F" />
<map_variables variable_1="k0_23" variable_2="k0_23" />
</connection>
<connection>
<map_components component_1="parameters" component_2="rate_constants" />
<map_variables variable_1="alpha_pp" variable_2="alpha_pp" />
<map_variables variable_1="C_T" variable_2="C_T" />
<map_variables variable_1="k0_54" variable_2="k0_54" />
<map_variables variable_1="z_c" variable_2="z_c" />
<map_variables variable_1="k0_65" variable_2="k0_65" />
<map_variables variable_1="k0_43" variable_2="k0_43" />
<map_variables variable_1="z_Na" variable_2="z_Na" />
<map_variables variable_1="k0_23" variable_2="k0_23" />
<map_variables variable_1="n" variable_2="n" />
<map_variables variable_1="k0_12" variable_2="k0_12" />
<map_variables variable_1="k0_32" variable_2="k0_32" />
<map_variables variable_1="delta" variable_2="delta" />
<map_variables variable_1="k0_56" variable_2="k0_56" />
<map_variables variable_1="k0_52" variable_2="k0_52" />
<map_variables variable_1="k0_45" variable_2="k0_45" />
<map_variables variable_1="k0_34" variable_2="k0_34" />
<map_variables variable_1="alpha_p" variable_2="alpha_p" />
<map_variables variable_1="k0_21" variable_2="k0_21" />
<map_variables variable_1="k0_16" variable_2="k0_16" />
<map_variables variable_1="k0_61" variable_2="k0_61" />
<map_variables variable_1="mu" variable_2="mu" />
<map_variables variable_1="k0_25" variable_2="k0_25" />
</connection>
<connection>
<map_components component_1="environment" component_2="ion_concentrations" />
<map_variables variable_1="time" variable_2="time" />
</connection>
<connection>
<map_components component_1="parameters" component_2="kinetic_equations" />
<map_variables variable_1="C_T" variable_2="C_T" />
</connection>
<connection>
<map_components component_1="ion_concentrations" component_2="rate_constants" />
<map_variables variable_1="glucose_o" variable_2="glucose_o" />
<map_variables variable_1="Na_i" variable_2="Na_i" />
<map_variables variable_1="glucose_i" variable_2="glucose_i" />
<map_variables variable_1="Na_o" variable_2="Na_o" />
</connection>
<connection>
<map_components component_1="parameters" component_2="NBC_current" />
<map_variables variable_1="alpha_pp" variable_2="alpha_pp" />
<map_variables variable_1="alpha_p" variable_2="alpha_p" />
<map_variables variable_1="F" variable_2="F" />
<map_variables variable_1="z_c" variable_2="z_c" />
<map_variables variable_1="z_Na" variable_2="z_Na" />
<map_variables variable_1="n" variable_2="n" />
<map_variables variable_1="delta" variable_2="delta" />
</connection>
<connection>
<map_components component_1="ion_concentrations" component_2="phenomonological_constants" />
<map_variables variable_1="glucose_o" variable_2="glucose_o" />
<map_variables variable_1="Na_o" variable_2="Na_o" />
</connection>
<connection>
<map_components component_1="ion_concentrations" component_2="parameters" />
<map_variables variable_1="V" variable_2="V" />
</connection>
<rdf:RDF xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:j.0="http://www.example.org/foo/bar/" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:ro="http://www.obofoundry.org/ro/ro.owl#" xmlns:opb="http://bhi.washington.edu/OPB#" xmlns:j.1="http://imc.org/vCard/3.0#">
<rdf:Description rdf:about="#NBC_current.C_6">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_10">
<semsim:physicalPropertyOf>
<rdf:Description rdf:about="#entity_8">
<ro:part_of>
<rdf:Description rdf:about="#entity_0">
<ro:part_of>
<rdf:Description rdf:about="#entity_1">
<semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/cl/CL:0000023" />
</rdf:Description>
</ro:part_of>
<semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/fma/FMA:63841" />
</rdf:Description>
</ro:part_of>
<semsim:name>Internal Unbound SGLT2 Cotransporter</semsim:name>
</rdf:Description>
</semsim:physicalPropertyOf>
<semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_00425" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>Pre-steady state internal unbound cotransporter concentration</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#ion_concentrations.V">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_31">
<semsim:physicalPropertyOf rdf:resource="#entity_0" />
<semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_00506" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>Electrical potential of the cell membrane</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#parameters.k0_32">
<dcterms:description>Rate constant for release of glucose from external CNaS</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#king_altman_states.k_34">
<dcterms:description>Rate for external CNaS to internal CNas reaction step</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#kinetic_equations.k_23">
<dcterms:description>Rate for binding of glucose to external CNa binding site</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#rate_constants.k_34">
<dcterms:description>Rate for external CNaS to internal CNas reaction step</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#parameters.alpha_pp">
<dcterms:description>Fraction of membrane electric field between bulk solution and internal face Na binding site.</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#phenomonological_constants.gamma">
<dcterms:description>Membrane dislocation</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#NBC_current.delta">
<dcterms:description>Fraction of the membrane field sensed by the empty binding on the carrier durring translocation.</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#NBC_current.C2">
<dcterms:description>Steady state external Na bound cotransporter concentration</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#phenomonological_constants.k_43">
<dcterms:description>Rate for internal CNaS to external CNaS reaction step</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#NBC_current.C_5">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_9">
<semsim:physicalPropertyOf>
<rdf:Description rdf:about="#entity_7">
<ro:part_of rdf:resource="#entity_0" />
<semsim:name>Internal Na Bound SGLT2 Cotransporter</semsim:name>
</rdf:Description>
</semsim:physicalPropertyOf>
<semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_00425" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>Pre-steady state internal CNa concentration</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#NBC_current.alpha_p">
<dcterms:description>Fraction of membrane electric field between bulk solution and external face Na binding site.</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#parameters.k0_43">
<dcterms:description>Rate constant for internal CNaS to external CNaS reaction step</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#NBC_current.J_Na">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_11">
<semsim:physicalPropertyOf>
<rdf:Description rdf:about="#process_0" dcterms:description="">
<semsim:hasMediatorParticipant>
<rdf:Description rdf:about="#mediator_3">
<semsim:hasPhysicalEntityReference>
<rdf:Description rdf:about="#entity_6">
<ro:part_of rdf:resource="#entity_0" />
<semsim:name>External Na Bound SGLT2 Cotransporter</semsim:name>
</rdf:Description>
</semsim:hasPhysicalEntityReference>
</rdf:Description>
</semsim:hasMediatorParticipant>
<semsim:hasMediatorParticipant>
<rdf:Description rdf:about="#mediator_2">
<semsim:hasPhysicalEntityReference>
<rdf:Description rdf:about="#entity_3">
<ro:part_of rdf:resource="#entity_0" />
<semsim:name>External Na and Substrate Bound SGLT2 Cotransporter</semsim:name>
</rdf:Description>
</semsim:hasPhysicalEntityReference>
</rdf:Description>
</semsim:hasMediatorParticipant>
<semsim:hasMediatorParticipant>
<rdf:Description rdf:about="#mediator_1">
<semsim:hasPhysicalEntityReference>
<rdf:Description rdf:about="#entity_4">
<ro:part_of rdf:resource="#entity_0" />
<semsim:name>Internal Na and Substrate Bound SGLT2 Cotransporter</semsim:name>
</rdf:Description>
</semsim:hasPhysicalEntityReference>
</rdf:Description>
</semsim:hasMediatorParticipant>
<semsim:hasMediatorParticipant>
<rdf:Description rdf:about="#mediator_0">
<semsim:hasPhysicalEntityReference rdf:resource="#entity_7" />
</rdf:Description>
</semsim:hasMediatorParticipant>
<semsim:hasSinkParticipant>
<rdf:Description rdf:about="#sink_0" semsim:hasMultiplier="1.0">
<semsim:hasPhysicalEntityReference>
<rdf:Description rdf:about="#entity_11">
<ro:part_of>
<rdf:Description rdf:about="#entity_12">
<ro:part_of rdf:resource="#entity_1" />
<semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/fma/FMA:66836" />
</rdf:Description>
</ro:part_of>
<semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/chebi/CHEBI:29101" />
</rdf:Description>
</semsim:hasPhysicalEntityReference>
</rdf:Description>
</semsim:hasSinkParticipant>
<semsim:hasSourceParticipant>
<rdf:Description rdf:about="#source_0" semsim:hasMultiplier="1.0">
<semsim:hasPhysicalEntityReference>
<rdf:Description rdf:about="#entity_9">
<ro:part_of>
<rdf:Description rdf:about="#entity_10">
<semsim:name>Cell culture medium</semsim:name>
</rdf:Description>
</ro:part_of>
<semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/chebi/CHEBI:29101" />
</rdf:Description>
</semsim:hasPhysicalEntityReference>
</rdf:Description>
</semsim:hasSourceParticipant>
<semsim:name>Sodium ion flow into cytosol via SGLT2 cotransporter</semsim:name>
</rdf:Description>
</semsim:physicalPropertyOf>
<semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_00318" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>Sodium ion flow into the cytosol</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#king_altman_states.k_45">
<dcterms:description>Rate constant for release of glucose from internal CNaS</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#NBC_current.n">
<dcterms:description>Sodium-glucose coupling coefficent</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#king_altman_states.k_21">
<dcterms:description>Rate for sodium ion release from external bound cotransporter.</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#kinetic_equations.k_12">
<dcterms:description>Rate for sodium ion binding to external unbound cotransporter.</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#rate_constants.k_23">
<dcterms:description>Rate for binding of glucose to external CNa binding site</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="http://www.cellml.org/cellml/1.0#mackenzie_1996">
<dc:title>The Mackenzie et al 1996 quantitative model of the Na/glucose cotransporter (SGLT2).</dc:title>
<cmeta:comment rdf:parseType="Resource">
<rdf:value>This is the CellML description of the Mackenzie et al 1996 quantitative model of the Na/glucose cotransporter (SGLT2).</rdf:value>
<dc:creator rdf:parseType="Resource">
<vCard:FN>Jonna Terkildsen</vCard:FN>
</dc:creator>
</cmeta:comment>
<bqs:reference rdf:parseType="Resource">
<dc:subject rdf:parseType="Resource">
<bqs:subject_type>keyword</bqs:subject_type>
<rdf:value>
<rdf:Bag>
<rdf:li>Na/glucose cotransport</rdf:li>
<rdf:li>ion transport</rdf:li>
</rdf:Bag>
</rdf:value>
</dc:subject>
</bqs:reference>
<bqs:reference rdf:parseType="Resource">
<bqs:Pubmed_id>8955098</bqs:Pubmed_id>
<bqs:JournalArticle rdf:parseType="Resource">
<dc:creator>
<rdf:Seq>
<rdf:li rdf:parseType="Resource">
<bqs:Person rdf:parseType="Resource">
<vCard:N vCard:Family="Mackenzie" vCard:Given="M" />
</bqs:Person>
</rdf:li>
<rdf:li rdf:parseType="Resource">
<bqs:Person rdf:parseType="Resource">
<vCard:N rdf:parseType="Resource">
<vCard:Family>Loo</vCard:Family>
<vCard:Given>D</vCard:Given>
<vCard:Other>D</vCard:Other>
<vCard:Other>F</vCard:Other>
</vCard:N>
</bqs:Person>
</rdf:li>
<rdf:li rdf:parseType="Resource">
<bqs:Person rdf:parseType="Resource">
<vCard:N vCard:Family="Panayotova-Heiermann" vCard:Given="M" />
</bqs:Person>
</rdf:li>
<rdf:li rdf:parseType="Resource">
<bqs:Person rdf:parseType="Resource">
<vCard:N vCard:Family="Wright" vCard:Given="E" vCard:Other="M" />
</bqs:Person>
</rdf:li>
</rdf:Seq>
</dc:creator>
<dc:title>Biophysical Characteristics of the Pig Kidney Na/Glucose Cotransporter SGLT2 Reveal a Common Mechanism for SGLT1 and SGLT2</dc:title>
<bqs:Journal rdf:parseType="Resource">
<dc:title>Journal of Biological Chemistry</dc:title>
</bqs:Journal>
<bqs:volume>271</bqs:volume>
<bqs:first_page>32678</bqs:first_page>
<bqs:last_page>32683</bqs:last_page>
</bqs:JournalArticle>
</bqs:reference>
</rdf:Description>
<rdf:Description rdf:about="#NBC_current.k_61">
<dcterms:description>Rate for internal unbound cotransporter binding site to external unbound cotransporter binding site reaction step</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#phenomonological_constants.k_54">
<dcterms:description>Rate for binding of glucose to internal CNa binding site</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#ion_concentrations.glucose_i">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_29">
<semsim:physicalPropertyOf>
<rdf:Description rdf:about="#entity_13">
<ro:part_of rdf:resource="#entity_12" />
<semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/chebi/CHEBI:320061" />
</rdf:Description>
</semsim:physicalPropertyOf>
<semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>Intracellular glucose concentration</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#NBC_current.C1">
<dcterms:description>Steady state external unbound cotransporter concentration</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#phenomonological_constants.Imax_Na">
<dcterms:description>Maximum sodium current across cell membrane</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#parameters.k0_34">
<dcterms:description>Rate constant for external CNaS to internal CNas reaction step</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#NBC_current.z_Na">
<dcterms:description>Na valence</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#parameters.area">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_2">
<semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_00295" />
</rdf:Description>
</semsim:isComputationalComponentFor>
</rdf:Description>
<rdf:Description rdf:about="#NBC_current.z_c">
<dcterms:description>Empty transporter valence</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#parameters.n">
<dcterms:description>Sodium-glucose coupling coefficent</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#ion_concentrations.Na_o">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_30">
<semsim:physicalPropertyOf rdf:resource="#entity_9" />
<semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>Sodium concentration in cell culture medium</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#king_altman_states.k_56">
<dcterms:description>Rate for release of Sodium from internal Na bound cotransporter</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#kinetic_equations.k_25">
<dcterms:description>Rate for external CNa to internal CNa reaction step.</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#king_altman_states.k_32">
<dcterms:description>Rate for release of glucose from external CNaS</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#rate_constants.k_56">
<dcterms:description>Rate for release of Sodium from internal Na bound cotransporter</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#phenomonological_constants.ks_12">
<dcterms:description>Sodium concentration independent rate for sodium ion binding to external unbound cotransporter.</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#rate_constants.k_32">
<dcterms:description>Rate for release of glucose from external CNaS</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#rate_constants.k0_23">
<dcterms:description>Rate constant for binding of glucose to external CNa binding site</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#phenomonological_constants.k_21">
<dcterms:description>Rate for sodium ion release from external bound cotransporter.</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#phenomonological_constants.k_45">
<dcterms:description>Rate constant for release of glucose from internal CNaS</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#NBC_current.alpha_pp">
<dcterms:description>Fraction of membrane electric field between bulk solution and internal face Na binding site.</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#parameters.k0_45">
<dcterms:description>Rate constant for release of glucose from internal CNaS</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#rate_constants.k0_25">
<dcterms:description>Rate constant for external CNa to internal CNa reaction step.</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#phenomonological_constants.C_T">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_20">
<semsim:physicalPropertyOf>
<rdf:Description rdf:about="#entity_2">
<ro:part_of rdf:resource="#entity_0" />
<semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/chebi/CHEBI:73273" />
</rdf:Description>
</semsim:physicalPropertyOf>
<semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_00425" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>Density of functional SGLT2 carriers in the oocyte membrane</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#parameters.k0_21">
<dcterms:description>Rate constant for sodium ion release from external bound cotransporter.</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#kinetic_equations.time">
<dcterms:description>Time - Solution Domain</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#king_altman_states.k_43">
<dcterms:description>Rate for internal CNaS to external CNaS reaction step</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#rate_constants.k_45">
<dcterms:description>Rate for release of glucose from internal CNaS</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#rate_constants.k_21">
<dcterms:description>Rate for sodium ion release from external bound cotransporter.</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#rate_constants.k0_12">
<dcterms:description>Rate constant for sodium ion binding to external unbound cotransporter.</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#phenomonological_constants.k_32">
<dcterms:description>Rate for release of glucose from external CNaS</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#phenomonological_constants.k_56">
<dcterms:description>Rate for release of Sodium from internal Na bound cotransporter</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#parameters.k0_12">
<dcterms:description>Rate constant for sodium ion binding to external unbound cotransporter.</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#phenomonological_constants.k0_23">
<dcterms:description>Rate constant for binding of glucose to external CNa binding site</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#phenomonological_constants.Khalf_Na">
<dcterms:description>Experimental substrate sodium concentration for half maximal current.</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#king_altman_states.C5">
<dcterms:description>Steady state internal CNa concentration</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#NBC_current.k_52">
<dcterms:description>Rate for internal CNa to external CNa reaction step</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#rate_constants.alpha_pp">
<dcterms:description>Fraction of membrane electric field between bulk solution and internal face Na binding site.</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#king_altman_states.k_54">
<dcterms:description>Rate for binding of glucose to internal CNa binding site</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#rate_constants.k_54">
<dcterms:description>Rate for binding of glucose to internal CNa binding site</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#rate_constants.k0_45">
<dcterms:description>Rate constant for release of glucose from internal CNaS</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#NBC_current.C_2">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_8">
<semsim:physicalPropertyOf rdf:resource="#entity_6" />
<semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_00425" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>Pre-steady state external Na bound cotransporter concentration</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#rate_constants.k0_21">
<dcterms:description>Rate constant for sodium ion release from external bound cotransporter.</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#phenomonological_constants.k_23">
<dcterms:description>Rate for binding of glucose to external CNa binding site</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#parameters.k0_23">
<dcterms:description>Rate constant for binding of glucose to external CNa binding site</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#king_altman_states.C4">
<dcterms:description>Steady state internal CNaS concentration</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#rate_constants.n">
<dcterms:description>Sodium-glucose coupling coefficent</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#NBC_current.k_65">
<dcterms:description>Rate for sodium ion release from internal Na bound cotransporter.</dcterms:description>
</rdf:Description>
<j.0:bazfoo />
<rdf:Description rdf:about="#king_altman_states.k_65">
<dcterms:description>Rate for sodium ion release from internal Na bound cotransporter.</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#NBC_current.I_NaGl_pSS">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_12">
<semsim:physicalPropertyOf>
<rdf:Description rdf:about="#process_1" dcterms:description="">
<semsim:hasMediatorParticipant>
<rdf:Description rdf:about="#mediator_6">
<semsim:hasPhysicalEntityReference rdf:resource="#entity_8" />
</rdf:Description>
</semsim:hasMediatorParticipant>
<semsim:hasMediatorParticipant>
<rdf:Description rdf:about="#mediator_5">
<semsim:hasPhysicalEntityReference rdf:resource="#entity_6" />
</rdf:Description>
</semsim:hasMediatorParticipant>
<semsim:hasMediatorParticipant>
<rdf:Description rdf:about="#mediator_4">
<semsim:hasPhysicalEntityReference>
<rdf:Description rdf:about="#entity_5">
<ro:part_of rdf:resource="#entity_0" />
<semsim:name>External Unbound SGLT2 Cotransporter</semsim:name>
</rdf:Description>
</semsim:hasPhysicalEntityReference>
</rdf:Description>
</semsim:hasMediatorParticipant>
<semsim:hasSinkParticipant>
<rdf:Description rdf:about="#sink_1" semsim:hasMultiplier="1.0">
<semsim:hasPhysicalEntityReference>
<rdf:Description rdf:about="#entity_14">
<ro:part_of rdf:resource="#entity_10" />
<semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/chebi/CHEBI:320061" />
</rdf:Description>
</semsim:hasPhysicalEntityReference>
</rdf:Description>
</semsim:hasSinkParticipant>
<semsim:hasSourceParticipant>
<rdf:Description rdf:about="#source_1" semsim:hasMultiplier="1.0">
<semsim:hasPhysicalEntityReference rdf:resource="#entity_13" />
</rdf:Description>
</semsim:hasSourceParticipant>
<semsim:name>Glucose transport across cell membrane via SGLT2 cotransporters</semsim:name>
</rdf:Description>
</semsim:physicalPropertyOf>
<semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_00318" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>Na-glucose pre-steady state current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#rate_constants.Na_i">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_14">
<semsim:physicalPropertyOf rdf:resource="#entity_11" />
<semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>Intracellular sodium concentration</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#environment.time">
<dcterms:description>Time - Solution Domain</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#kinetic_equations.k_16">
<dcterms:description>Rate for external unbound transport site to internal unbound transport site reaction step</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#rate_constants.k_43">
<dcterms:description>Rate for internal CNaS to external CNaS reaction step</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#rate_constants.k0_34">
<dcterms:description>Rate constant for external CNaS to internal CNas reaction step</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#phenomonological_constants.k_34">
<dcterms:description>Rate for external CNaS to internal CNas reaction step</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#NBC_current.C_1">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_7">
<semsim:physicalPropertyOf rdf:resource="#entity_5" />
<semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_00425" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>Pre-steady state external unbound cotransporter concentration</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#phenomonological_constants.glucose_o">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_18">
<semsim:physicalPropertyOf rdf:resource="#entity_14" />
<semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>Glucose concentration in experimental medium</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#rate_constants.glucose_o">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_13">
<semsim:physicalPropertyOf rdf:resource="#entity_14" />
<semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>Glucose concentration in experimental medium</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#king_altman_states.k_52">
<dcterms:description>Rate for internal CNa to external CNa reaction step</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#phenomonological_constants.k_25">
<dcterms:description>Rate for external CNa to internal CNa reaction step.</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#NBC_current.C_4">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_6">
<semsim:physicalPropertyOf rdf:resource="#entity_4" />
<semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_00425" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>Steady state internal CNaS concentration</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#rate_constants.k_52">
<dcterms:description>Rate for internal CNa to external CNa reaction step</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#rate_constants.k0_43">
<dcterms:description>Rate constant for internal CNaS to external CNaS reaction step</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#parameters.k0_25">
<dcterms:description>Rate constant for external CNa to internal CNa reaction step.</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#NBC_current.F">
<dcterms:description>Faraday constant</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#kinetic_equations.k_61">
<dcterms:description>Rate for internal unbound cotransporter binding site to external unbound cotransporter binding site reaction step</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#king_altman_states.C6">
<dcterms:description>Steady state internal unbound cotransporter concentration</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#NBC_current.k_43">
<dcterms:description>Rate for internal CNaS to external CNaS reaction step</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#ion_concentrations.glucose_o">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_32">
<semsim:physicalPropertyOf rdf:resource="#entity_14" />
<semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>Glucose concentration in experimental medium</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#rate_constants.k_65">
<dcterms:description>Rate for sodium ion release from internal Na bound cotransporter.</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#rate_constants.k0_56">
<dcterms:description>Rate constant for release of Sodium from internal Na bound cotransporter</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#NBC_current.C_3">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_5">
<semsim:physicalPropertyOf rdf:resource="#entity_3" />
<semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_00425" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>Pre-steady state external CNaS concentration</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#rate_constants.k0_32">
<dcterms:description>Rate constant for release of glucose from external CNaS</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#phenomonological_constants.k_12">
<dcterms:description>Rate for sodium ion binding to external unbound cotransporter.</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#parameters.k0_16">
<dcterms:description>Rate constant for external unbound transport site to internal unbound transport site reaction step</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#ion_concentrations.Na_i">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_33">
<semsim:physicalPropertyOf rdf:resource="#entity_11" />
<semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>Intracellular sodium concentration</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#king_altman_states.C1">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_4">
<semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_00425" />
</rdf:Description>
</semsim:isComputationalComponentFor>
</rdf:Description>
<rdf:Description rdf:about="#kinetic_equations.C_5">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_23">
<semsim:physicalPropertyOf rdf:resource="#entity_7" />
<semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_00425" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>Pre-steady state internal CNa concentration</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#NBC_current.k_56">
<dcterms:description>Rate for release of Sodium from internal Na bound cotransporter</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#rate_constants.k0_65">
<dcterms:description>Rate constant for sodium ion release from internal Na bound cotransporter.</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#parameters.delta">
<dcterms:description>Fraction of the membrane field sensed by the empty binding on the carrier durring translocation.</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#rate_constants.C_T">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_16">
<semsim:physicalPropertyOf rdf:resource="#entity_2" />
<semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_00425" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>Density of functional SGLT2 carriers in the oocyte membrane</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#phenomonological_constants.lambda">
<dcterms:description>Sum of all enzymes.</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#NBC_current.k_21">
<dcterms:description>Rate for sodium ion release from external bound cotransporter.</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#king_altman_states.k_61">
<dcterms:description>Rate for internal unbound cotransporter binding site to external unbound cotransporter binding site reaction step</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#kinetic_equations.C_6">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_22">
<semsim:physicalPropertyOf rdf:resource="#entity_8" />
<semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_00425" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>Pre-steady state internal unbound cotransporter concentration</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#kinetic_equations.k_52">
<dcterms:description>Rate for internal CNa to external CNa reaction step</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#rate_constants.k0_54">
<dcterms:description>Rate constant for binding of glucose to internal CNa binding site</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#king_altman_states.C_T">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_3">
<semsim:physicalPropertyOf rdf:resource="#entity_2" />
<semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_00425" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>Density of functional SGLT2 carriers in the oocyte membrane</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#kinetic_equations.C_6_temp">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_21">
<semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_00425" />
</rdf:Description>
</semsim:isComputationalComponentFor>
</rdf:Description>
<rdf:Description rdf:about="#parameters.alpha_p">
<dcterms:description>Fraction of membrane electric field between bulk solution and external face Na binding site.</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#phenomonological_constants.F">
<dcterms:description>Faraday constant</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#rate_constants.k_16">
<dcterms:description>Rate for external unbound transport site to internal unbound transport site reaction step</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#king_altman_states.C3">
<dcterms:description>Steady state external CNaS concentration</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#kinetic_equations.k_65">
<dcterms:description>Rate for sodium ion release from internal Na bound cotransporter.</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#NBC_current.k_34">
<dcterms:description>Rate for external CNaS to internal CNas reaction step</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#rate_constants.mu">
<dcterms:description>Relationship between membrane voltage and F*R/T.</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#king_altman_states.k_16">
<dcterms:description>Rate for external unbound transport site to internal unbound transport site reaction step</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#phenomonological_constants.k_61">
<dcterms:description>Rate for internal unbound cotransporter binding site to external unbound cotransporter binding site reaction step</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#phenomonological_constants.Na_o">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_19">
<semsim:physicalPropertyOf rdf:resource="#entity_9" />
<semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>Sodium concentration in cell culture medium</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#MacKenzie_1996" semsim:modelId="mackenzie_1996" semsim:AnnotatorContactInfo="thompsct@umich.edu" semsim:modelName="mackenzie_1996">
<semsim:ModelDescription>Model of the pig kidney Na1/Glucose cotransporter SGLT2</semsim:ModelDescription>
</rdf:Description>
<rdf:Description rdf:about="#kinetic_equations.C_T">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_25">
<semsim:physicalPropertyOf rdf:resource="#entity_2" />
<semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_00425" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>Density of functional SGLT2 carriers in the oocyte membrane</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#kinetic_equations.C_3">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_26">
<semsim:physicalPropertyOf rdf:resource="#entity_3" />
<semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_00425" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>Pre-steady state external CNaS concentration</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#king_altman_states.C2">
<dcterms:description>Steady state external Na bound cotransporter concentration</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#parameters.V">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_0">
<semsim:physicalPropertyOf rdf:resource="#entity_0" />
<semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_00506" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>Electrical potential of the cell membrane</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#parameters.k0_61">
<dcterms:description>Rate constant for internal unbound cotransporter binding site to external unbound cotransporter binding site reaction step</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#rate_constants.Na_o">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_15">
<semsim:physicalPropertyOf rdf:resource="#entity_9" />
<semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>Sodium concentration in cell culture medium</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#kinetic_equations.k_54">
<dcterms:description>Rate for binding of glucose to internal CNa binding site</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#rate_constants.k_52_temp">
<dcterms:description>Glucose concentration independent rate for internal CNa to external CNa reaction step</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#phenomonological_constants.k_16">
<dcterms:description>Rate for external unbound transport site to internal unbound transport site reaction step</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#rate_constants.k0_52">
<dcterms:description>Rate constant for internal CNa to external CNa reaction step</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#parameters.F">
<dcterms:description>Faraday constant</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#rate_constants.z_c">
<dcterms:description>Empty transporter valence</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#kinetic_equations.C_4">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_24">
<semsim:physicalPropertyOf rdf:resource="#entity_4" />
<semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_00425" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>Steady state internal CNaS concentration</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#rate_constants.k_61">
<dcterms:description>Rate for internal unbound cotransporter binding site to external unbound cotransporter binding site reaction step</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#rate_constants.alpha_p">
<dcterms:description>Fraction of membrane electric field between bulk solution and external face Na binding site.</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#parameters.k0_52">
<dcterms:description>Rate constant for internal CNa to external CNa reaction step</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#NBC_current.C6">
<dcterms:description>Steady state internal unbound cotransporter concentration</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#kinetic_equations.k_43">
<dcterms:description>Rate for internal CNaS to external CNaS reaction step</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="http://www.cellml.org/cellml/1.0">
<dc:creator rdf:parseType="Resource">
<vCard:N vCard:Family="Terkildsen" vCard:Given="Jonna" />
<vCard:EMAIL rdf:value="j.terkildsen@auckland.ac.nz" rdf:type="http://imc.org/vCard/3.0#internet" />
<vCard:ORG rdf:parseType="Resource">
<vCard:Orgname>Auckland Bioengineering Institute</vCard:Orgname>
</vCard:ORG>
</dc:creator>
<dcterms:created dcterms:W3CDTF="2009-10-28" />
</rdf:Description>
<rdf:Description rdf:about="#NBC_current.k_12">
<dcterms:description>Rate for sodium ion binding to external unbound cotransporter.</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#rate_constants.k0_61">
<dcterms:description>Rate constant for internal unbound cotransporter binding site to external unbound cotransporter binding site reaction step</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#kinetic_equations.C_1">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_28">
<semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_00425" />
</rdf:Description>
</semsim:isComputationalComponentFor>
</rdf:Description>
<rdf:Description rdf:about="#parameters.N_Avo">
<dcterms:description>Avogadro's number</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#parameters.T" dcterms:description="Temperature" />
<rdf:Description rdf:about="#rate_constants.z_Na">
<dcterms:description>Na valence</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#phenomonological_constants.Khalf_gluc">
<dcterms:description>Experimental substrate glucose concentration for half maximal current.</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#parameters.mu">
<dcterms:description>Relationship between membrane voltage and F*R/T.</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#kinetic_equations.k_32">
<dcterms:description>Rate for release of glucose from external CNaS</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#NBC_current.C5">
<dcterms:description>Steady state internal CNa concentration</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#rate_constants.k0_54_temp">
<dcterms:description>Glucose independent rate constant for binding of glucose to internal CNa binding site</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#NBC_current.k_25">
<dcterms:description>Rate for external CNa to internal CNa reaction step.</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#parameters.z_Na">
<dcterms:description>Na valence</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#kinetic_equations.k_56">
<dcterms:description>Rate for release of Sodium from internal Na bound cotransporter</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#rate_constants.glucose_i">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_17">
<semsim:physicalPropertyOf rdf:resource="#entity_13" />
<semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>Intracellular glucose concentration</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#king_altman_states.k_25">
<dcterms:description>Rate for external CNa to internal CNa reaction step.</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#parameters.z_c">
<dcterms:description>Empty transporter valence</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#kinetic_equations.C_2">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_27">
<semsim:physicalPropertyOf rdf:resource="#entity_6" />
<semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_00425" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>Pre-steady state external Na bound cotransporter concentration</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#rate_constants.k0_16">
<dcterms:description>Rate constant for external unbound transport site to internal unbound transport site reaction step</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#NBC_current.I_NaGl_SS">
<dcterms:description>Na glucose steady state current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#phenomonological_constants.Imax_gluc">
<dcterms:description>Maximum glucose current across cell membrane</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#parameters.k0_54">
<dcterms:description>Rate constant for binding of glucose to internal CNa binding site</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#kinetic_equations.k_21">
<dcterms:description>Rate for sodium ion release from external bound cotransporter.</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#NBC_current.C4">
<dcterms:description>Steady state internal CNaS concentration</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#king_altman_states.k_12">
<dcterms:description>Rate for sodium ion binding to external unbound cotransporter.</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#kinetic_equations.k_45">
<dcterms:description>Rate constant for release of glucose from internal CNaS</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#rate_constants.k_12">
<dcterms:description>Rate for sodium ion binding to external unbound cotransporter.</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#phenomonological_constants.k_65">
<dcterms:description>Rate for sodium ion release from internal Na bound cotransporter.</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#rate_constants.delta">
<dcterms:description>Fraction of the membrane field sensed by the empty binding on the carrier durring translocation.</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#rate_constants.k_25">
<dcterms:description>Rate for external CNa to internal CNa reaction step.</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#parameters.C_T">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_1">
<semsim:physicalPropertyOf rdf:resource="#entity_2" />
<semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_00425" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>Density of functional SGLT2 carriers in the oocyte membrane</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#NBC_current.k_16">
<dcterms:description>Rate for external unbound transport site to internal unbound transport site reaction step</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#parameters.R">
<dcterms:description>Boltzmann constant</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#rate_constants.ks_12">
<dcterms:description>Sodium concentration independent rate for sodium ion binding to external unbound cotransporter.</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#parameters.k0_65">
<dcterms:description>Rate constant for sodium ion release from internal Na bound cotransporter.</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#king_altman_states.k_23">
<dcterms:description>Rate for binding of glucose to external CNa binding site</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#kinetic_equations.k_34">
<dcterms:description>Rate for external CNaS to internal CNas reaction step</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#phenomonological_constants.k_52">
<dcterms:description>Rate for internal CNa to external CNa reaction step</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#ion_concentrations.time">
<dcterms:description>Time - Solution Domain</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#NBC_current.C3">
<dcterms:description>Steady state external CNaS concentration</dcterms:description>
</rdf:Description>
</rdf:RDF>
</model>
