Location: semantic-annotation @ dcab0d9157ad / hinch_greenstein_tanskanen_xu_winslow_2004.cellml

Author:
Dewan Sarwar <sarwarcse@gmail.com>
Date:
2019-03-11 12:09:49+13:00
Desc:
added blood capillary flux model
Permanent Source URI:
https://models.physiomeproject.org/workspace/584/rawfile/dcab0d9157ad4fb602c5084666c323fb3e30323a/hinch_greenstein_tanskanen_xu_winslow_2004.cellml

<?xml version="1.0" encoding="UTF-8"?>
<model xmlns="http://www.cellml.org/cellml/1.1#" xmlns:cmeta="http://www.cellml.org/metadata/1.0#" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bqs="http://www.cellml.org/bqs/1.0#" xmlns:semsim="http://www.bhi.washington.edu/SemSim#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" name="hinch_greenstein_tanskanen_xu_winslow_2004" cmeta:id="Hinch_2004">
  <documentation xmlns="http://cellml.org/tmp-documentation">
    <article>
      <section id="sec_status">
        <title>Model Status</title>
        <para>This model is known to run in OpenCell and COR to reproduce the output shown in the publication.</para>
      </section>
      <sect1 id="sec_structure">
        <title>Model Structure</title>
        <para>ABSTRACT: Calcium (Ca2+)-induced Ca2+ release (CICR) in cardiac myocytes exhibits high gain and is graded. These properties result from local control of Ca2+ release. Existing local control models of Ca2+ release in which interactions between L-Type Ca2+ channels (LCCs) and ryanodine-sensitive Ca2+ release channels (RyRs) are simulated stochastically are able to reconstruct these properties, but only at high computational cost. Here we present a general analytical approach for deriving simplified models of local control of CICR, consisting of low-dimensional systems of coupled ordinary differential equations, from these more complex local control models in which LCC-RyR interactions are simulated stochastically. The resulting model, referred to as the coupled LCC-RyR gating model, successfully reproduces a range of experimental data, including L-Type Ca2+ current in response to voltage-clamp stimuli, inactivation of LCC current with and without Ca2+ release from the sarcoplasmic reticulum, voltage-dependence of excitation-contraction coupling gain, graded release, and the force-frequency relationship. The model does so with low computational cost.</para>
        <para>The original publication reference is cited below:</para>
        <para>
          A Simplified Local Control Model of Calcium-Induced Calcium Release in Cardiac Ventricular Myocytes, R. Hinch, J.R. Greenstein, A.J. Tanskanen, L. Xu, R.L. Winslow, 2004
          <emphasis>Biophysical Journal</emphasis>
          , 87, 3723-3736,
          <ulink url="http://www.ncbi.nlm.nih.gov/pubmed/15465866">PubMed ID: 15465866</ulink>
        </para>
        <informalfigure float="0" id="cell_diagram">
          <mediaobject>
            <imageobject>
              <objectinfo>
                <title>state diagram</title>
              </objectinfo>
              <imagedata fileref="hinch_2004.png" />
            </imageobject>
          </mediaobject>
          <caption>Schematic diagram of the currents and the ion exchanges described by the cardiac ventricular myocyte model.</caption>
        </informalfigure>
        <informalfigure float="0" id="markov_diagram">
          <mediaobject>
            <imageobject>
              <objectinfo>
                <title>state diagram</title>
              </objectinfo>
              <imagedata fileref="hinch_2004b.png" />
            </imageobject>
          </mediaobject>
          <caption>The nine-state Markov model of the calcium release unit (CaRU). In state yij, the LCC is in the state i and the RyR is in the state j.</caption>
        </informalfigure>
      </sect1>
    </article>
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                      <divide />
                      <apply>
                        <times />
                        <apply>
                          <divide />
                          <ci>J_L</ci>
                          <ci>g_D</ci>
                        </apply>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.00001</cn>
                      </apply>
                      <apply>
                        <minus />
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                        <apply>
                          <exp />
                          <apply>
                            <minus />
                            <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.00001</cn>
                          </apply>
                        </apply>
                      </apply>
                    </apply>
                    <apply>
                      <minus />
                      <ci>Ca_SR</ci>
                      <apply>
                        <times />
                        <ci>Ca_o</ci>
                        <apply>
                          <exp />
                          <apply>
                            <minus />
                            <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.00001</cn>
                          </apply>
                        </apply>
                      </apply>
                    </apply>
                  </apply>
                </apply>
              </apply>
              <apply>
                <plus />
                <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                <apply>
                  <divide />
                  <ci>J_R</ci>
                  <ci>g_D</ci>
                </apply>
                <apply>
                  <divide />
                  <apply>
                    <times />
                    <apply>
                      <divide />
                      <ci>J_L</ci>
                      <ci>g_D</ci>
                    </apply>
                    <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.00001</cn>
                  </apply>
                  <apply>
                    <minus />
                    <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                    <apply>
                      <exp />
                      <apply>
                        <minus />
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.00001</cn>
                      </apply>
                    </apply>
                  </apply>
                </apply>
              </apply>
            </apply>
          </otherwise>
        </piecewise>
      </apply>
      <apply>
        <eq />
        <ci>J_Loc</ci>
        <piecewise>
          <piece>
            <apply>
              <divide />
              <apply>
                <times />
                <apply>
                  <divide />
                  <apply>
                    <times />
                    <ci>J_L</ci>
                    <ci>FVRT_Ca</ci>
                  </apply>
                  <apply>
                    <minus />
                    <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                    <apply>
                      <exp />
                      <apply>
                        <minus />
                        <ci>FVRT_Ca</ci>
                      </apply>
                    </apply>
                  </apply>
                </apply>
                <apply>
                  <minus />
                  <apply>
                    <times />
                    <ci>Ca_o</ci>
                    <apply>
                      <exp />
                      <apply>
                        <minus />
                        <ci>FVRT_Ca</ci>
                      </apply>
                    </apply>
                  </apply>
                  <ci>Ca_i</ci>
                </apply>
              </apply>
              <apply>
                <plus />
                <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                <apply>
                  <divide />
                  <apply>
                    <times />
                    <apply>
                      <divide />
                      <ci>J_L</ci>
                      <ci>g_D</ci>
                    </apply>
                    <ci>FVRT_Ca</ci>
                  </apply>
                  <apply>
                    <minus />
                    <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                    <apply>
                      <exp />
                      <apply>
                        <minus />
                        <ci>FVRT_Ca</ci>
                      </apply>
                    </apply>
                  </apply>
                </apply>
              </apply>
            </apply>
            <apply>
              <gt />
              <apply>
                <abs />
                <ci>FVRT_Ca</ci>
              </apply>
              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.00001</cn>
            </apply>
          </piece>
          <otherwise>
            <apply>
              <divide />
              <apply>
                <times />
                <apply>
                  <divide />
                  <apply>
                    <times />
                    <ci>J_L</ci>
                    <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.00001</cn>
                  </apply>
                  <apply>
                    <minus />
                    <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                    <apply>
                      <exp />
                      <apply>
                        <minus />
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.00001</cn>
                      </apply>
                    </apply>
                  </apply>
                </apply>
                <apply>
                  <minus />
                  <apply>
                    <times />
                    <ci>Ca_o</ci>
                    <apply>
                      <exp />
                      <apply>
                        <minus />
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.00001</cn>
                      </apply>
                    </apply>
                  </apply>
                  <ci>Ca_i</ci>
                </apply>
              </apply>
              <apply>
                <plus />
                <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                <apply>
                  <divide />
                  <apply>
                    <times />
                    <apply>
                      <divide />
                      <ci>J_L</ci>
                      <ci>g_D</ci>
                    </apply>
                    <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.00001</cn>
                  </apply>
                  <apply>
                    <minus />
                    <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                    <apply>
                      <exp />
                      <apply>
                        <minus />
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.00001</cn>
                      </apply>
                    </apply>
                  </apply>
                </apply>
              </apply>
            </apply>
          </otherwise>
        </piecewise>
      </apply>
      <apply>
        <eq />
        <ci>J_Loo</ci>
        <piecewise>
          <piece>
            <apply>
              <divide />
              <apply>
                <times />
                <apply>
                  <divide />
                  <apply>
                    <times />
                    <ci>J_L</ci>
                    <ci>FVRT_Ca</ci>
                  </apply>
                  <apply>
                    <minus />
                    <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                    <apply>
                      <exp />
                      <apply>
                        <minus />
                        <ci>FVRT_Ca</ci>
                      </apply>
                    </apply>
                  </apply>
                </apply>
                <apply>
                  <plus />
                  <apply>
                    <minus />
                    <apply>
                      <times />
                      <ci>Ca_o</ci>
                      <apply>
                        <exp />
                        <apply>
                          <minus />
                          <ci>FVRT_Ca</ci>
                        </apply>
                      </apply>
                    </apply>
                    <ci>Ca_i</ci>
                  </apply>
                  <apply>
                    <times />
                    <apply>
                      <divide />
                      <ci>J_R</ci>
                      <ci>g_D</ci>
                    </apply>
                    <apply>
                      <minus />
                      <apply>
                        <times />
                        <ci>Ca_o</ci>
                        <apply>
                          <exp />
                          <apply>
                            <minus />
                            <ci>FVRT_Ca</ci>
                          </apply>
                        </apply>
                      </apply>
                      <ci>Ca_SR</ci>
                    </apply>
                  </apply>
                </apply>
              </apply>
              <apply>
                <plus />
                <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                <apply>
                  <divide />
                  <ci>J_R</ci>
                  <ci>g_D</ci>
                </apply>
                <apply>
                  <divide />
                  <apply>
                    <times />
                    <apply>
                      <divide />
                      <ci>J_L</ci>
                      <ci>g_D</ci>
                    </apply>
                    <ci>FVRT_Ca</ci>
                  </apply>
                  <apply>
                    <minus />
                    <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                    <apply>
                      <exp />
                      <ci>FVRT_Ca</ci>
                    </apply>
                  </apply>
                </apply>
              </apply>
            </apply>
            <apply>
              <gt />
              <apply>
                <abs />
                <ci>FVRT_Ca</ci>
              </apply>
              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.00001</cn>
            </apply>
          </piece>
          <otherwise>
            <apply>
              <divide />
              <apply>
                <times />
                <apply>
                  <divide />
                  <apply>
                    <times />
                    <ci>J_L</ci>
                    <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.00001</cn>
                  </apply>
                  <apply>
                    <minus />
                    <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                    <apply>
                      <exp />
                      <apply>
                        <minus />
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.00001</cn>
                      </apply>
                    </apply>
                  </apply>
                </apply>
                <apply>
                  <plus />
                  <apply>
                    <minus />
                    <apply>
                      <times />
                      <ci>Ca_o</ci>
                      <apply>
                        <exp />
                        <apply>
                          <minus />
                          <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.00001</cn>
                        </apply>
                      </apply>
                    </apply>
                    <ci>Ca_i</ci>
                  </apply>
                  <apply>
                    <times />
                    <apply>
                      <divide />
                      <ci>J_R</ci>
                      <ci>g_D</ci>
                    </apply>
                    <apply>
                      <minus />
                      <apply>
                        <times />
                        <ci>Ca_o</ci>
                        <apply>
                          <exp />
                          <apply>
                            <minus />
                            <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.00001</cn>
                          </apply>
                        </apply>
                      </apply>
                      <ci>Ca_SR</ci>
                    </apply>
                  </apply>
                </apply>
              </apply>
              <apply>
                <plus />
                <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                <apply>
                  <divide />
                  <ci>J_R</ci>
                  <ci>g_D</ci>
                </apply>
                <apply>
                  <divide />
                  <apply>
                    <times />
                    <apply>
                      <divide />
                      <ci>J_L</ci>
                      <ci>g_D</ci>
                    </apply>
                    <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.00001</cn>
                  </apply>
                  <apply>
                    <minus />
                    <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                    <apply>
                      <exp />
                      <apply>
                        <minus />
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.00001</cn>
                      </apply>
                    </apply>
                  </apply>
                </apply>
              </apply>
            </apply>
          </otherwise>
        </piecewise>
      </apply>
    </math>
  </component>
  <component name="convert_hinch">
    <variable cmeta:id="convert_hinch.hinch_I_pCa" name="hinch_I_pCa" public_interface="in" units="mM_per_ms" />
    <variable cmeta:id="convert_hinch.hinch_I_LCC" name="hinch_I_LCC" public_interface="in" units="mM_per_ms" />
    <variable cmeta:id="convert_hinch.I_pCa" name="I_pCa" public_interface="out" units="uA" />
    <variable cmeta:id="convert_hinch.I_LCC" name="I_LCC" public_interface="out" units="uA" />
    <variable cmeta:id="convert_hinch.hinch_I_RyR" name="hinch_I_RyR" public_interface="in" units="mM_per_ms" />
    <variable cmeta:id="convert_hinch.I_RyR" name="I_RyR" public_interface="out" units="mM_per_ms" />
    <variable cmeta:id="convert_hinch.hinch_I_CaB" name="hinch_I_CaB" public_interface="in" units="mM_per_ms" />
    <variable cmeta:id="convert_hinch.hinch_I_NaCa" name="hinch_I_NaCa" public_interface="in" units="mM_per_ms" />
    <variable cmeta:id="convert_hinch.V_myo" name="V_myo" public_interface="in" units="um3" />
    <variable cmeta:id="convert_hinch.I_NaCa" name="I_NaCa" public_interface="out" units="uA" />
    <variable cmeta:id="convert_hinch.F" name="F" public_interface="in" units="C_per_mole" />
    <variable cmeta:id="convert_hinch.I_CaB" name="I_CaB" public_interface="out" units="uA" />
    <math xmlns="http://www.w3.org/1998/Math/MathML">
      <apply>
        <eq />
        <ci>I_LCC</ci>
        <apply>
          <times />
          <apply>
            <minus />
            <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1.5</cn>
          </apply>
          <ci>hinch_I_LCC</ci>
          <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
          <ci>V_myo</ci>
          <ci>F</ci>
        </apply>
      </apply>
      <apply>
        <eq />
        <ci>I_NaCa</ci>
        <apply>
          <times />
          <ci>hinch_I_NaCa</ci>
          <ci>V_myo</ci>
          <ci>F</ci>
        </apply>
      </apply>
      <apply>
        <eq />
        <ci>I_pCa</ci>
        <apply>
          <times />
          <ci>hinch_I_pCa</ci>
          <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
          <ci>V_myo</ci>
          <ci>F</ci>
        </apply>
      </apply>
      <apply>
        <eq />
        <ci>I_CaB</ci>
        <apply>
          <times />
          <apply>
            <minus />
            <ci>hinch_I_CaB</ci>
          </apply>
          <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
          <ci>V_myo</ci>
          <ci>F</ci>
        </apply>
      </apply>
      <apply>
        <eq />
        <ci>I_RyR</ci>
        <apply>
          <times />
          <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1.5</cn>
          <ci>hinch_I_RyR</ci>
        </apply>
      </apply>
    </math>
  </component>
  <component name="troponin_Ca_buffer">
    <variable cmeta:id="troponin_Ca_buffer.Ca_i" name="Ca_i" public_interface="in" units="mM" />
    <variable cmeta:id="troponin_Ca_buffer.k_p_TRPN" name="k_p_TRPN" units="per_mM_ms" />
    <variable cmeta:id="troponin_Ca_buffer.B_TRPN" name="B_TRPN" units="mM" />
    <variable cmeta:id="troponin_Ca_buffer.k_m_TRPN" name="k_m_TRPN" units="per_ms" />
    <variable cmeta:id="troponin_Ca_buffer.TRPN" name="TRPN" public_interface="in" units="mM" />
    <variable cmeta:id="troponin_Ca_buffer.I_TRPN" name="I_TRPN" public_interface="out" units="mM_per_ms" />
    <math xmlns="http://www.w3.org/1998/Math/MathML">
      <apply>
        <eq />
        <ci>I_TRPN</ci>
        <apply>
          <minus />
          <apply>
            <times />
            <ci>k_m_TRPN</ci>
            <apply>
              <minus />
              <ci>B_TRPN</ci>
              <ci>TRPN</ci>
            </apply>
          </apply>
          <apply>
            <times />
            <ci>k_p_TRPN</ci>
            <ci>TRPN</ci>
            <ci>Ca_i</ci>
          </apply>
        </apply>
      </apply>
    </math>
  </component>
  <component name="RyR_current">
    <variable cmeta:id="RyR_current.y_co" name="y_co" public_interface="in" units="dimensionless" />
    <variable cmeta:id="RyR_current.J_Roo" name="J_Roo" public_interface="in" units="um3_mM_per_ms" />
    <variable cmeta:id="RyR_current.beta_pcc" name="beta_pcc" public_interface="in" units="per_ms" />
    <variable cmeta:id="RyR_current.z_3" name="z_3" public_interface="in" units="dimensionless" />
    <variable cmeta:id="RyR_current.J_R3" name="J_R3" public_interface="out" units="um3_mM_per_ms" />
    <variable cmeta:id="RyR_current.y_oc" name="y_oc" public_interface="in" units="dimensionless" />
    <variable cmeta:id="RyR_current.J_R1" name="J_R1" public_interface="out" units="um3_mM_per_ms" />
    <variable cmeta:id="RyR_current.J_Rco" name="J_Rco" public_interface="in" units="um3_mM_per_ms" />
    <variable cmeta:id="RyR_current.y_oo" name="y_oo" public_interface="in" units="dimensionless" />
    <variable cmeta:id="RyR_current.z_1" name="z_1" public_interface="in" units="dimensionless" />
    <variable cmeta:id="RyR_current_I_RyR" name="I_RyR" public_interface="out" units="mM_per_ms" />
    <variable cmeta:id="RyR_current.N" name="N" public_interface="in" units="dimensionless" />
    <variable cmeta:id="RyR_current.V_myo" name="V_myo" public_interface="in" units="um3" />
    <variable cmeta:id="RyR_current.beta_m" name="beta_m" public_interface="in" units="per_ms" />
    <math xmlns="http://www.w3.org/1998/Math/MathML">
      <apply>
        <eq />
        <ci>J_R1</ci>
        <apply>
          <plus />
          <apply>
            <times />
            <ci>y_oo</ci>
            <ci>J_Roo</ci>
          </apply>
          <apply>
            <times />
            <ci>J_Rco</ci>
            <ci>y_co</ci>
          </apply>
        </apply>
      </apply>
      <apply>
        <eq />
        <ci>J_R3</ci>
        <apply>
          <divide />
          <apply>
            <times />
            <ci>J_Rco</ci>
            <ci>beta_pcc</ci>
          </apply>
          <apply>
            <plus />
            <ci>beta_m</ci>
            <ci>beta_pcc</ci>
          </apply>
        </apply>
      </apply>
      <apply>
        <eq />
        <ci>I_RyR</ci>
        <apply>
          <divide />
          <apply>
            <times />
            <apply>
              <plus />
              <apply>
                <times />
                <ci>z_1</ci>
                <ci>J_R1</ci>
              </apply>
              <apply>
                <times />
                <ci>z_3</ci>
                <ci>J_R3</ci>
              </apply>
            </apply>
            <ci>N</ci>
          </apply>
          <ci>V_myo</ci>
        </apply>
      </apply>
    </math>
  </component>
  <component name="SR_Ca_leak_current">
    <variable cmeta:id="SR_Ca_leak_current.Ca_i" name="Ca_i" public_interface="in" units="mM" />
    <variable cmeta:id="SR_Ca_leak_current.g_SRl" name="g_SRl" units="per_ms" />
    <variable cmeta:id="SR_Ca_leak_current.Ca_SR" name="Ca_SR" public_interface="in" units="mM" />
    <variable cmeta:id="SR_Ca_leak_current_I_SR" name="I_SR" public_interface="out" units="mM_per_ms" />
    <math xmlns="http://www.w3.org/1998/Math/MathML">
      <apply>
        <eq />
        <ci>I_SR</ci>
        <apply>
          <times />
          <ci>g_SRl</ci>
          <apply>
            <minus />
            <ci>Ca_SR</ci>
            <ci>Ca_i</ci>
          </apply>
        </apply>
      </apply>
    </math>
  </component>
  <component name="LCC_current">
    <variable cmeta:id="LCC_current.y_oo" name="y_oo" public_interface="in" units="dimensionless" />
    <variable cmeta:id="LCC_current.J_Loo" name="J_Loo" public_interface="in" units="um3_mM_per_ms" />
    <variable cmeta:id="LCC_current.N" name="N" public_interface="in" units="dimensionless" />
    <variable cmeta:id="LCC_current_I_LCC" name="I_LCC" public_interface="out" units="mM_per_ms" />
    <variable cmeta:id="LCC_current.alpha_p" name="alpha_p" public_interface="in" units="per_ms" />
    <variable cmeta:id="LCC_current.z_2" name="z_2" public_interface="in" units="dimensionless" />
    <variable cmeta:id="LCC_current.J_Loc" name="J_Loc" public_interface="in" units="um3_mM_per_ms" />
    <variable cmeta:id="LCC_current.alpha_m" name="alpha_m" public_interface="in" units="per_ms" />
    <variable cmeta:id="LCC_current.J_L2" name="J_L2" public_interface="out" units="um3_mM_per_ms" />
    <variable cmeta:id="LCC_current.z_1" name="z_1" public_interface="in" units="dimensionless" />
    <variable cmeta:id="LCC_current.V_myo" name="V_myo" public_interface="in" units="um3" />
    <variable cmeta:id="LCC_current.y_oc" name="y_oc" public_interface="in" units="dimensionless" />
    <variable cmeta:id="LCC_current.J_L1" name="J_L1" public_interface="out" units="um3_mM_per_ms" />
    <math xmlns="http://www.w3.org/1998/Math/MathML">
      <apply>
        <eq />
        <ci>J_L1</ci>
        <apply>
          <plus />
          <apply>
            <times />
            <ci>J_Loo</ci>
            <ci>y_oo</ci>
          </apply>
          <apply>
            <times />
            <ci>J_Loc</ci>
            <ci>y_oc</ci>
          </apply>
        </apply>
      </apply>
      <apply>
        <eq />
        <ci>J_L2</ci>
        <apply>
          <divide />
          <apply>
            <times />
            <ci>J_Loc</ci>
            <ci>alpha_p</ci>
          </apply>
          <apply>
            <plus />
            <ci>alpha_p</ci>
            <ci>alpha_m</ci>
          </apply>
        </apply>
      </apply>
      <apply>
        <eq />
        <ci>I_LCC</ci>
        <apply>
          <divide />
          <apply>
            <times />
            <apply>
              <plus />
              <apply>
                <times />
                <ci>z_1</ci>
                <ci>J_L1</ci>
              </apply>
              <apply>
                <times />
                <ci>z_2</ci>
                <ci>J_L2</ci>
              </apply>
            </apply>
            <ci>N</ci>
          </apply>
          <ci>V_myo</ci>
        </apply>
      </apply>
    </math>
  </component>
  <component name="SERCA">
    <variable cmeta:id="SERCA.K_SERCA" name="K_SERCA" units="mM" />
    <variable cmeta:id="SERCA.g_SERCA" name="g_SERCA" units="mM_per_ms" />
    <variable cmeta:id="SERCA.Ca_i" name="Ca_i" public_interface="in" units="mM" />
    <variable cmeta:id="SERCA_I_SERCA" name="I_SERCA" public_interface="out" units="mM_per_ms" />
    <math xmlns="http://www.w3.org/1998/Math/MathML">
      <apply>
        <eq />
        <ci>I_SERCA</ci>
        <apply>
          <divide />
          <apply>
            <times />
            <ci>g_SERCA</ci>
            <apply>
              <power />
              <ci>Ca_i</ci>
              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
            </apply>
          </apply>
          <apply>
            <plus />
            <apply>
              <power />
              <ci>K_SERCA</ci>
              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
            </apply>
            <apply>
              <power />
              <ci>Ca_i</ci>
              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
            </apply>
          </apply>
        </apply>
      </apply>
    </math>
  </component>
  <component name="CaRU_states">
    <variable cmeta:id="CaRU_states.denom" name="denom" units="per_ms3" />
    <variable cmeta:id="CaRU_states.beta_pcc" name="beta_pcc" public_interface="in" units="per_ms" />
    <variable cmeta:id="CaRU_states.y_co" name="y_co" public_interface="out" units="dimensionless" />
    <variable cmeta:id="CaRU_states.y_oc" name="y_oc" public_interface="out" units="dimensionless" />
    <variable cmeta:id="CaRU_states.y_ic" name="y_ic" public_interface="out" units="dimensionless" />
    <variable cmeta:id="CaRU_states.y_oi" name="y_oi" public_interface="out" units="dimensionless" />
    <variable cmeta:id="CaRU_states.alpha_m" name="alpha_m" public_interface="in" units="per_ms" />
    <variable cmeta:id="CaRU_states.beta_m" name="beta_m" public_interface="in" units="per_ms" />
    <variable cmeta:id="CaRU_states.alpha_p" name="alpha_p" public_interface="in" units="per_ms" />
    <variable cmeta:id="CaRU_states.beta_poc" name="beta_poc" public_interface="in" units="per_ms" />
    <variable cmeta:id="CaRU_states.y_cc" name="y_cc" public_interface="out" units="dimensionless" />
    <variable cmeta:id="CaRU_states.y_ii" name="y_ii" public_interface="out" units="dimensionless" />
    <variable cmeta:id="CaRU_states.y_oo" name="y_oo" public_interface="out" units="dimensionless" />
    <variable cmeta:id="CaRU_states.y_ci" name="y_ci" public_interface="out" units="dimensionless" />
    <variable cmeta:id="CaRU_states.y_io" name="y_io" public_interface="out" units="dimensionless" />
    <math xmlns="http://www.w3.org/1998/Math/MathML">
      <apply>
        <eq />
        <ci>denom</ci>
        <apply>
          <times />
          <apply>
            <plus />
            <ci>alpha_p</ci>
            <ci>alpha_m</ci>
          </apply>
          <apply>
            <plus />
            <apply>
              <times />
              <apply>
                <plus />
                <ci>alpha_m</ci>
                <ci>beta_m</ci>
                <ci>beta_poc</ci>
              </apply>
              <apply>
                <plus />
                <ci>beta_m</ci>
                <ci>beta_pcc</ci>
              </apply>
            </apply>
            <apply>
              <times />
              <ci>alpha_p</ci>
              <apply>
                <plus />
                <ci>beta_m</ci>
                <ci>beta_poc</ci>
              </apply>
            </apply>
          </apply>
        </apply>
      </apply>
      <apply>
        <eq />
        <ci>y_oc</ci>
        <apply>
          <divide />
          <apply>
            <times />
            <ci>alpha_p</ci>
            <ci>beta_m</ci>
            <apply>
              <plus />
              <ci>alpha_p</ci>
              <ci>alpha_m</ci>
              <ci>beta_m</ci>
              <ci>beta_pcc</ci>
            </apply>
          </apply>
          <ci>denom</ci>
        </apply>
      </apply>
      <apply>
        <eq />
        <ci>y_co</ci>
        <apply>
          <divide />
          <apply>
            <times />
            <ci>alpha_m</ci>
            <apply>
              <plus />
              <apply>
                <times />
                <ci>beta_pcc</ci>
                <apply>
                  <plus />
                  <ci>alpha_m</ci>
                  <ci>beta_m</ci>
                  <ci>beta_poc</ci>
                </apply>
              </apply>
              <apply>
                <times />
                <ci>beta_poc</ci>
                <ci>alpha_p</ci>
              </apply>
            </apply>
          </apply>
          <ci>denom</ci>
        </apply>
      </apply>
      <apply>
        <eq />
        <ci>y_oo</ci>
        <apply>
          <divide />
          <apply>
            <times />
            <ci>alpha_p</ci>
            <apply>
              <plus />
              <apply>
                <times />
                <ci>beta_poc</ci>
                <apply>
                  <plus />
                  <ci>alpha_p</ci>
                  <ci>beta_m</ci>
                  <ci>beta_pcc</ci>
                </apply>
              </apply>
              <apply>
                <times />
                <ci>beta_pcc</ci>
                <ci>alpha_m</ci>
              </apply>
            </apply>
          </apply>
          <ci>denom</ci>
        </apply>
      </apply>
      <apply>
        <eq />
        <ci>y_cc</ci>
        <apply>
          <divide />
          <apply>
            <times />
            <ci>alpha_m</ci>
            <ci>beta_m</ci>
            <apply>
              <plus />
              <ci>alpha_m</ci>
              <ci>alpha_p</ci>
              <ci>beta_m</ci>
              <ci>beta_poc</ci>
            </apply>
          </apply>
          <ci>denom</ci>
        </apply>
      </apply>
      <apply>
        <eq />
        <ci>y_ci</ci>
        <apply>
          <divide />
          <ci>alpha_m</ci>
          <apply>
            <plus />
            <ci>alpha_p</ci>
            <ci>alpha_m</ci>
          </apply>
        </apply>
      </apply>
      <apply>
        <eq />
        <ci>y_oi</ci>
        <apply>
          <divide />
          <ci>alpha_p</ci>
          <apply>
            <plus />
            <ci>alpha_p</ci>
            <ci>alpha_m</ci>
          </apply>
        </apply>
      </apply>
      <apply>
        <eq />
        <ci>y_ic</ci>
        <apply>
          <divide />
          <ci>beta_m</ci>
          <apply>
            <plus />
            <ci>beta_pcc</ci>
            <ci>beta_m</ci>
          </apply>
        </apply>
      </apply>
      <apply>
        <eq />
        <ci>y_io</ci>
        <apply>
          <divide />
          <ci>beta_pcc</ci>
          <apply>
            <plus />
            <ci>beta_pcc</ci>
            <ci>beta_m</ci>
          </apply>
        </apply>
      </apply>
      <apply>
        <eq />
        <ci>y_ii</ci>
        <apply>
          <minus />
          <apply>
            <minus />
            <apply>
              <minus />
              <apply>
                <minus />
                <apply>
                  <minus />
                  <apply>
                    <minus />
                    <apply>
                      <minus />
                      <apply>
                        <minus />
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                        <ci>y_oc</ci>
                      </apply>
                      <ci>y_co</ci>
                    </apply>
                    <ci>y_oo</ci>
                  </apply>
                  <ci>y_cc</ci>
                </apply>
                <ci>y_ci</ci>
              </apply>
              <ci>y_ic</ci>
            </apply>
            <ci>y_oi</ci>
          </apply>
          <ci>y_io</ci>
        </apply>
      </apply>
    </math>
  </component>
  <component name="CaRU_Transitions">
    <variable cmeta:id="CaRU_Transitions.C_oc" name="C_oc" public_interface="in" units="mM" />
    <variable cmeta:id="CaRU_Transitions.phi_R" name="phi_R" units="dimensionless" />
    <variable cmeta:id="CaRU_Transitions.V" name="V" public_interface="in" units="mV" />
    <variable cmeta:id="CaRU_Transitions.tau_R" name="tau_R" units="ms" />
    <variable cmeta:id="CaRU_Transitions.theta_R" name="theta_R" units="dimensionless" />
    <variable cmeta:id="CaRU_Transitions.K_L" name="K_L" units="mM" />
    <variable cmeta:id="CaRU_Transitions.phi_L" name="phi_L" units="dimensionless" />
    <variable cmeta:id="CaRU_Transitions.beta_pcc" name="beta_pcc" public_interface="out" units="per_ms" />
    <variable cmeta:id="CaRU_Transitions.d" name="d" units="dimensionless" />
    <variable cmeta:id="CaRU_Transitions.c" name="c" units="dimensionless" />
    <variable cmeta:id="CaRU_Transitions.b" name="b" units="dimensionless" />
    <variable cmeta:id="CaRU_Transitions.a" name="a" units="dimensionless" />
    <variable cmeta:id="CaRU_Transitions.epsilon_pcc" name="epsilon_pcc" public_interface="out" units="per_ms" />
    <variable cmeta:id="CaRU_Transitions.mu_pcc" name="mu_pcc" public_interface="out" units="per_ms" />
    <variable cmeta:id="CaRU_Transitions.beta_m" name="beta_m" public_interface="out" units="per_ms" />
    <variable cmeta:id="CaRU_Transitions.tau_L" name="tau_L" units="ms" />
    <variable cmeta:id="CaRU_Transitions.V_L" name="V_L" units="mV" />
    <variable cmeta:id="CaRU_Transitions.epsilon_pco" name="epsilon_pco" public_interface="out" units="per_ms" />
    <variable cmeta:id="CaRU_Transitions.expVL" name="expVL" units="dimensionless" />
    <variable cmeta:id="CaRU_Transitions.mu_moc" name="mu_moc" public_interface="out" units="per_ms" />
    <variable cmeta:id="CaRU_Transitions.mu_poc" name="mu_poc" public_interface="out" units="per_ms" />
    <variable cmeta:id="CaRU_Transitions.del_VL" name="del_VL" units="mV" />
    <variable cmeta:id="CaRU_Transitions.C_co" name="C_co" public_interface="in" units="mM" />
    <variable cmeta:id="CaRU_Transitions.Ca_i" name="Ca_i" public_interface="in" units="mM" />
    <variable cmeta:id="CaRU_Transitions.mu_mcc" name="mu_mcc" public_interface="out" units="per_ms" />
    <variable cmeta:id="CaRU_Transitions.alpha_p" name="alpha_p" public_interface="out" units="per_ms" />
    <variable cmeta:id="CaRU_Transitions.alpha_m" name="alpha_m" public_interface="out" units="per_ms" />
    <variable cmeta:id="CaRU_Transitions.beta_poc" name="beta_poc" public_interface="out" units="per_ms" />
    <variable cmeta:id="CaRU_Transitions.t_R" name="t_R" units="ms" />
    <variable cmeta:id="CaRU_Transitions.epsilon_m" name="epsilon_m" public_interface="out" units="per_ms" />
    <variable cmeta:id="CaRU_Transitions.t_L" name="t_L" units="ms" />
    <variable cmeta:id="CaRU_Transitions.K_RyR" name="K_RyR" units="mM" />
    <math xmlns="http://www.w3.org/1998/Math/MathML">
      <apply>
        <eq />
        <ci>expVL</ci>
        <apply>
          <exp />
          <apply>
            <divide />
            <apply>
              <minus />
              <ci>V</ci>
              <ci>V_L</ci>
            </apply>
            <ci>del_VL</ci>
          </apply>
        </apply>
      </apply>
      <apply>
        <eq />
        <ci>t_R</ci>
        <apply>
          <times />
          <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1.17</cn>
          <ci>t_L</ci>
        </apply>
      </apply>
      <apply>
        <eq />
        <ci>alpha_p</ci>
        <apply>
          <divide />
          <ci>expVL</ci>
          <apply>
            <times />
            <ci>t_L</ci>
            <apply>
              <plus />
              <ci>expVL</ci>
              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
            </apply>
          </apply>
        </apply>
      </apply>
      <apply>
        <eq />
        <ci>alpha_m</ci>
        <apply>
          <divide />
          <ci>phi_L</ci>
          <ci>t_L</ci>
        </apply>
      </apply>
      <apply>
        <eq />
        <ci>beta_poc</ci>
        <apply>
          <divide />
          <apply>
            <power />
            <ci>C_oc</ci>
            <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
          </apply>
          <apply>
            <times />
            <ci>t_R</ci>
            <apply>
              <plus />
              <apply>
                <power />
                <ci>C_oc</ci>
                <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
              </apply>
              <apply>
                <power />
                <ci>K_RyR</ci>
                <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
              </apply>
            </apply>
          </apply>
        </apply>
      </apply>
      <apply>
        <eq />
        <ci>beta_pcc</ci>
        <apply>
          <divide />
          <apply>
            <power />
            <ci>Ca_i</ci>
            <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
          </apply>
          <apply>
            <times />
            <ci>t_R</ci>
            <apply>
              <plus />
              <apply>
                <power />
                <ci>Ca_i</ci>
                <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
              </apply>
              <apply>
                <power />
                <ci>K_RyR</ci>
                <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
              </apply>
            </apply>
          </apply>
        </apply>
      </apply>
      <apply>
        <eq />
        <ci>beta_m</ci>
        <apply>
          <divide />
          <ci>phi_R</ci>
          <ci>t_R</ci>
        </apply>
      </apply>
      <apply>
        <eq />
        <ci>epsilon_pco</ci>
        <apply>
          <divide />
          <apply>
            <times />
            <ci>C_co</ci>
            <apply>
              <plus />
              <ci>expVL</ci>
              <ci>a</ci>
            </apply>
          </apply>
          <apply>
            <times />
            <ci>tau_L</ci>
            <ci>K_L</ci>
            <apply>
              <plus />
              <ci>expVL</ci>
              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
            </apply>
          </apply>
        </apply>
      </apply>
      <apply>
        <eq />
        <ci>epsilon_pcc</ci>
        <apply>
          <divide />
          <apply>
            <times />
            <ci>Ca_i</ci>
            <apply>
              <plus />
              <ci>expVL</ci>
              <ci>a</ci>
            </apply>
          </apply>
          <apply>
            <times />
            <ci>tau_L</ci>
            <ci>K_L</ci>
            <apply>
              <plus />
              <ci>expVL</ci>
              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
            </apply>
          </apply>
        </apply>
      </apply>
      <apply>
        <eq />
        <ci>epsilon_m</ci>
        <apply>
          <divide />
          <apply>
            <times />
            <ci>b</ci>
            <apply>
              <plus />
              <ci>expVL</ci>
              <ci>a</ci>
            </apply>
          </apply>
          <apply>
            <times />
            <ci>tau_L</ci>
            <apply>
              <plus />
              <apply>
                <times />
                <ci>b</ci>
                <ci>expVL</ci>
              </apply>
              <ci>a</ci>
            </apply>
          </apply>
        </apply>
      </apply>
      <apply>
        <eq />
        <ci>mu_poc</ci>
        <apply>
          <divide />
          <apply>
            <plus />
            <apply>
              <power />
              <ci>C_oc</ci>
              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
            </apply>
            <apply>
              <times />
              <ci>c</ci>
              <apply>
                <power />
                <ci>K_RyR</ci>
                <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
              </apply>
            </apply>
          </apply>
          <apply>
            <times />
            <ci>tau_R</ci>
            <apply>
              <plus />
              <apply>
                <power />
                <ci>C_oc</ci>
                <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
              </apply>
              <apply>
                <power />
                <ci>K_RyR</ci>
                <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
              </apply>
            </apply>
          </apply>
        </apply>
      </apply>
      <apply>
        <eq />
        <ci>mu_pcc</ci>
        <apply>
          <divide />
          <apply>
            <plus />
            <apply>
              <power />
              <ci>Ca_i</ci>
              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
            </apply>
            <apply>
              <times />
              <ci>c</ci>
              <apply>
                <power />
                <ci>K_RyR</ci>
                <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
              </apply>
            </apply>
          </apply>
          <apply>
            <times />
            <ci>tau_R</ci>
            <apply>
              <plus />
              <apply>
                <power />
                <ci>Ca_i</ci>
                <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
              </apply>
              <apply>
                <power />
                <ci>K_RyR</ci>
                <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
              </apply>
            </apply>
          </apply>
        </apply>
      </apply>
      <apply>
        <eq />
        <ci>mu_moc</ci>
        <apply>
          <divide />
          <apply>
            <times />
            <ci>theta_R</ci>
            <ci>d</ci>
            <apply>
              <plus />
              <apply>
                <power />
                <ci>C_oc</ci>
                <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
              </apply>
              <apply>
                <times />
                <ci>c</ci>
                <apply>
                  <power />
                  <ci>K_RyR</ci>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                </apply>
              </apply>
            </apply>
          </apply>
          <apply>
            <times />
            <ci>tau_R</ci>
            <apply>
              <plus />
              <apply>
                <times />
                <ci>d</ci>
                <apply>
                  <power />
                  <ci>C_oc</ci>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                </apply>
              </apply>
              <apply>
                <times />
                <ci>c</ci>
                <apply>
                  <power />
                  <ci>K_RyR</ci>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                </apply>
              </apply>
            </apply>
          </apply>
        </apply>
      </apply>
      <apply>
        <eq />
        <ci>mu_mcc</ci>
        <apply>
          <divide />
          <apply>
            <times />
            <ci>theta_R</ci>
            <ci>d</ci>
            <apply>
              <plus />
              <apply>
                <power />
                <ci>Ca_i</ci>
                <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
              </apply>
              <apply>
                <times />
                <ci>c</ci>
                <apply>
                  <power />
                  <ci>K_RyR</ci>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                </apply>
              </apply>
            </apply>
          </apply>
          <apply>
            <times />
            <ci>tau_R</ci>
            <apply>
              <plus />
              <apply>
                <times />
                <ci>d</ci>
                <apply>
                  <power />
                  <ci>Ca_i</ci>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                </apply>
              </apply>
              <apply>
                <times />
                <ci>c</ci>
                <apply>
                  <power />
                  <ci>K_RyR</ci>
                  <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
                </apply>
              </apply>
            </apply>
          </apply>
        </apply>
      </apply>
    </math>
  </component>
  <component name="intracellular_ion_concentrations">
    <variable cmeta:id="intracellular_ion_concentrations.Ca_SR" name="Ca_SR" public_interface="out" units="mM" />
    <variable cmeta:id="intracellular_ion_concentrations_Ca_i" name="Ca_i" public_interface="out" units="mM" />
    <variable cmeta:id="intracellular_ion_concentrations.beta_CMDN" name="beta_CMDN" public_interface="in" units="dimensionless" />
    <variable cmeta:id="intracellular_ion_concentrations_CaSR_plot" name="CaSR_plot" units="mM" />
    <variable cmeta:id="intracellular_ion_concentrations.I_CaB" name="I_CaB" public_interface="in" units="mM_per_ms" />
    <variable cmeta:id="intracellular_ion_concentrations.I_NaCa" name="I_NaCa" public_interface="in" units="mM_per_ms" />
    <variable cmeta:id="intracellular_ion_concentrations.Na_i" name="Na_i" public_interface="out" units="mM" />
    <variable cmeta:id="intracellular_ion_concentrations.time" name="time" public_interface="in" units="ms" />
    <variable cmeta:id="intracellular_ion_concentrations.I_SR" name="I_SR" public_interface="in" units="mM_per_ms" />
    <variable cmeta:id="intracellular_ion_concentrations.TRPN" name="TRPN" public_interface="out" units="mM" />
    <variable cmeta:id="intracellular_ion_concentrations.V_myo" name="V_myo" public_interface="in" units="um3" />
    <variable cmeta:id="intracellular_ion_concentrations.I_TRPN" name="I_TRPN" public_interface="in" units="mM_per_ms" />
    <variable cmeta:id="intracellular_ion_concentrations.I_SERCA" name="I_SERCA" public_interface="in" units="mM_per_ms" />
    <variable cmeta:id="intracellular_ion_concentrations.I_pCa" name="I_pCa" public_interface="in" units="mM_per_ms" />
    <variable cmeta:id="intracellular_ion_concentrations.V_SR" name="V_SR" public_interface="in" units="um3" />
    <variable cmeta:id="intracellular_ion_concentrations.I_RyR" name="I_RyR" public_interface="in" units="mM_per_ms" />
    <variable cmeta:id="intracellular_ion_concentrations.I_LCC" name="I_LCC" public_interface="in" units="mM_per_ms" />
    <math xmlns="http://www.w3.org/1998/Math/MathML">
      <apply>
        <eq />
        <apply>
          <diff />
          <bvar>
            <ci>time</ci>
          </bvar>
          <ci>TRPN</ci>
        </apply>
        <ci>I_TRPN</ci>
      </apply>
      <apply>
        <eq />
        <apply>
          <diff />
          <bvar>
            <ci>time</ci>
          </bvar>
          <ci>Ca_i</ci>
        </apply>
        <apply>
          <times />
          <ci>beta_CMDN</ci>
          <apply>
            <plus />
            <apply>
              <minus />
              <apply>
                <plus />
                <apply>
                  <minus />
                  <apply>
                    <plus />
                    <ci>I_LCC</ci>
                    <ci>I_RyR</ci>
                  </apply>
                  <ci>I_SERCA</ci>
                </apply>
                <ci>I_SR</ci>
                <ci>I_NaCa</ci>
              </apply>
              <ci>I_pCa</ci>
            </apply>
            <ci>I_CaB</ci>
            <ci>I_TRPN</ci>
          </apply>
        </apply>
      </apply>
      <apply>
        <eq />
        <apply>
          <diff />
          <bvar>
            <ci>time</ci>
          </bvar>
          <ci>Ca_SR</ci>
        </apply>
        <apply>
          <times />
          <apply>
            <divide />
            <ci>V_myo</ci>
            <ci>V_SR</ci>
          </apply>
          <apply>
            <minus />
            <apply>
              <plus />
              <apply>
                <minus />
                <ci>I_RyR</ci>
              </apply>
              <ci>I_SERCA</ci>
            </apply>
            <ci>I_SR</ci>
          </apply>
        </apply>
      </apply>
      <apply>
        <eq />
        <ci>CaSR_plot</ci>
        <apply>
          <divide />
          <apply>
            <times />
            <ci>Ca_SR</ci>
            <ci>V_SR</ci>
          </apply>
          <ci>V_myo</ci>
        </apply>
      </apply>
    </math>
  </component>
  <component name="DS_Calcium_Concentrations">
    <variable cmeta:id="DS_Calcium_Concentrations.Ca_SR" name="Ca_SR" public_interface="in" units="mM" />
    <variable cmeta:id="DS_Calcium_Concentrations.J_R" name="J_R" public_interface="in" units="um3_per_ms" />
    <variable cmeta:id="DS_Calcium_Concentrations.g_D" name="g_D" public_interface="in" units="um3_per_ms" />
    <variable cmeta:id="DS_Calcium_Concentrations.C_oc" name="C_oc" public_interface="out" units="mM" />
    <variable cmeta:id="DS_Calcium_Concentrations.Ca_o" name="Ca_o" public_interface="in" units="mM" />
    <variable cmeta:id="DS_Calcium_Concentrations.C_cc" name="C_cc" public_interface="out" units="mM" />
    <variable cmeta:id="DS_Calcium_Concentrations.C_oo" name="C_oo" public_interface="out" units="mM" />
    <variable cmeta:id="DS_Calcium_Concentrations.FVRT_Ca" name="FVRT_Ca" public_interface="in" units="dimensionless" />
    <variable cmeta:id="DS_Calcium_Concentrations.C_co" name="C_co" public_interface="out" units="mM" />
    <variable cmeta:id="DS_Calcium_Concentrations.Ca_i" name="Ca_i" public_interface="in" units="mM" />
    <variable cmeta:id="DS_Calcium_Concentrations.J_L" name="J_L" public_interface="in" units="um3_per_ms" />
    <math xmlns="http://www.w3.org/1998/Math/MathML">
      <apply>
        <eq />
        <ci>C_cc</ci>
        <ci>Ca_i</ci>
      </apply>
      <apply>
        <eq />
        <ci>C_co</ci>
        <apply>
          <divide />
          <apply>
            <plus />
            <ci>Ca_i</ci>
            <apply>
              <times />
              <apply>
                <divide />
                <ci>J_R</ci>
                <ci>g_D</ci>
              </apply>
              <ci>Ca_SR</ci>
            </apply>
          </apply>
          <apply>
            <plus />
            <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
            <apply>
              <divide />
              <ci>J_R</ci>
              <ci>g_D</ci>
            </apply>
          </apply>
        </apply>
      </apply>
      <apply>
        <eq />
        <ci>C_oc</ci>
        <piecewise>
          <piece>
            <apply>
              <divide />
              <apply>
                <plus />
                <ci>Ca_i</ci>
                <apply>
                  <divide />
                  <apply>
                    <times />
                    <apply>
                      <divide />
                      <ci>J_L</ci>
                      <ci>g_D</ci>
                    </apply>
                    <ci>Ca_o</ci>
                    <ci>FVRT_Ca</ci>
                    <apply>
                      <exp />
                      <apply>
                        <minus />
                        <ci>FVRT_Ca</ci>
                      </apply>
                    </apply>
                  </apply>
                  <apply>
                    <minus />
                    <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                    <apply>
                      <exp />
                      <apply>
                        <minus />
                        <ci>FVRT_Ca</ci>
                      </apply>
                    </apply>
                  </apply>
                </apply>
              </apply>
              <apply>
                <plus />
                <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                <apply>
                  <divide />
                  <apply>
                    <times />
                    <apply>
                      <divide />
                      <ci>J_L</ci>
                      <ci>g_D</ci>
                    </apply>
                    <ci>FVRT_Ca</ci>
                  </apply>
                  <apply>
                    <minus />
                    <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                    <apply>
                      <exp />
                      <apply>
                        <minus />
                        <ci>FVRT_Ca</ci>
                      </apply>
                    </apply>
                  </apply>
                </apply>
              </apply>
            </apply>
            <apply>
              <gt />
              <apply>
                <abs />
                <ci>FVRT_Ca</ci>
              </apply>
              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.000000001</cn>
            </apply>
          </piece>
          <otherwise>
            <apply>
              <divide />
              <apply>
                <plus />
                <ci>Ca_i</ci>
                <apply>
                  <times />
                  <apply>
                    <divide />
                    <ci>J_L</ci>
                    <ci>g_D</ci>
                  </apply>
                  <ci>Ca_o</ci>
                </apply>
              </apply>
              <apply>
                <plus />
                <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                <apply>
                  <divide />
                  <ci>J_L</ci>
                  <ci>g_D</ci>
                </apply>
              </apply>
            </apply>
          </otherwise>
        </piecewise>
      </apply>
      <apply>
        <eq />
        <ci>C_oo</ci>
        <piecewise>
          <piece>
            <apply>
              <divide />
              <apply>
                <plus />
                <ci>Ca_i</ci>
                <apply>
                  <times />
                  <apply>
                    <divide />
                    <ci>J_R</ci>
                    <ci>g_D</ci>
                  </apply>
                  <ci>Ca_SR</ci>
                </apply>
                <apply>
                  <divide />
                  <apply>
                    <times />
                    <apply>
                      <divide />
                      <ci>J_L</ci>
                      <ci>g_D</ci>
                    </apply>
                    <ci>Ca_o</ci>
                    <ci>FVRT_Ca</ci>
                    <apply>
                      <exp />
                      <apply>
                        <minus />
                        <ci>FVRT_Ca</ci>
                      </apply>
                    </apply>
                  </apply>
                  <apply>
                    <minus />
                    <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                    <apply>
                      <exp />
                      <apply>
                        <minus />
                        <ci>FVRT_Ca</ci>
                      </apply>
                    </apply>
                  </apply>
                </apply>
              </apply>
              <apply>
                <plus />
                <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                <apply>
                  <divide />
                  <ci>J_R</ci>
                  <ci>g_D</ci>
                </apply>
                <apply>
                  <divide />
                  <apply>
                    <times />
                    <apply>
                      <divide />
                      <ci>J_L</ci>
                      <ci>g_D</ci>
                    </apply>
                    <ci>FVRT_Ca</ci>
                  </apply>
                  <apply>
                    <minus />
                    <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                    <apply>
                      <exp />
                      <apply>
                        <minus />
                        <ci>FVRT_Ca</ci>
                      </apply>
                    </apply>
                  </apply>
                </apply>
              </apply>
            </apply>
            <apply>
              <gt />
              <apply>
                <abs />
                <ci>FVRT_Ca</ci>
              </apply>
              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.000000001</cn>
            </apply>
          </piece>
          <otherwise>
            <apply>
              <divide />
              <apply>
                <plus />
                <ci>Ca_i</ci>
                <apply>
                  <times />
                  <apply>
                    <divide />
                    <ci>J_R</ci>
                    <ci>g_D</ci>
                  </apply>
                  <ci>Ca_SR</ci>
                </apply>
                <apply>
                  <times />
                  <apply>
                    <divide />
                    <ci>J_L</ci>
                    <ci>g_D</ci>
                  </apply>
                  <ci>Ca_o</ci>
                </apply>
              </apply>
              <apply>
                <plus />
                <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                <apply>
                  <divide />
                  <ci>J_R</ci>
                  <ci>g_D</ci>
                </apply>
                <apply>
                  <divide />
                  <ci>J_L</ci>
                  <ci>g_D</ci>
                </apply>
              </apply>
            </apply>
          </otherwise>
        </piecewise>
      </apply>
    </math>
  </component>
  <component name="cell_geometry">
    <variable cmeta:id="cell_geometry.V_myo" name="V_myo" public_interface="out" units="um3" />
    <variable cmeta:id="cell_geometry.A_cap" name="A_cap" public_interface="out" units="um2" />
    <variable cmeta:id="cell_geometry.V_SR" name="V_SR" public_interface="out" units="um3" />
  </component>
  <component name="CaRU_reduced_states">
    <variable cmeta:id="CaRU_reduced_states.r_1" name="r_1" public_interface="out" units="per_ms" />
    <variable cmeta:id="CaRU_reduced_states.r_2" name="r_2" public_interface="out" units="per_ms" />
    <variable cmeta:id="CaRU_reduced_states.alpha_p" name="alpha_p" public_interface="in" units="per_ms" />
    <variable cmeta:id="CaRU_reduced_states.r_5" name="r_5" public_interface="out" units="per_ms" />
    <variable cmeta:id="CaRU_reduced_states.alpha_m" name="alpha_m" public_interface="in" units="per_ms" />
    <variable cmeta:id="CaRU_reduced_states.r_6" name="r_6" public_interface="out" units="per_ms" />
    <variable cmeta:id="CaRU_reduced_states.r_3" name="r_3" public_interface="out" units="per_ms" />
    <variable cmeta:id="CaRU_reduced_states.r_4" name="r_4" public_interface="out" units="per_ms" />
    <variable cmeta:id="CaRU_reduced_states.z_2" name="z_2" public_interface="out" units="dimensionless" />
    <variable cmeta:id="CaRU_reduced_states.beta_m" name="beta_m" public_interface="in" units="per_ms" />
    <variable cmeta:id="CaRU_reduced_states.z_1" name="z_1" public_interface="out" units="dimensionless" />
    <variable cmeta:id="CaRU_reduced_states.r_7" name="r_7" public_interface="out" units="per_ms" />
    <variable cmeta:id="CaRU_reduced_states.y_co" name="y_co" public_interface="in" units="dimensionless" />
    <variable cmeta:id="CaRU_reduced_states.r_8" name="r_8" public_interface="out" units="per_ms" />
    <variable cmeta:id="CaRU_reduced_states.z_4" name="z_4" public_interface="out" units="dimensionless" />
    <variable cmeta:id="CaRU_reduced_states.z_3" name="z_3" public_interface="out" units="dimensionless" />
    <variable cmeta:id="CaRU_reduced_states.epsilon_m" name="epsilon_m" public_interface="in" units="per_ms" />
    <variable cmeta:id="CaRU_reduced_states.time" name="time" public_interface="in" units="ms" />
    <variable cmeta:id="CaRU_reduced_states.beta_pcc" name="beta_pcc" public_interface="in" units="per_ms" />
    <variable cmeta:id="CaRU_reduced_states.mu_pcc" name="mu_pcc" public_interface="in" units="per_ms" />
    <variable cmeta:id="CaRU_reduced_states.mu_mcc" name="mu_mcc" public_interface="in" units="per_ms" />
    <variable cmeta:id="CaRU_reduced_states.y_oc" name="y_oc" public_interface="in" units="dimensionless" />
    <variable cmeta:id="CaRU_reduced_states.mu_poc" name="mu_poc" public_interface="in" units="per_ms" />
    <variable cmeta:id="CaRU_reduced_states.mu_moc" name="mu_moc" public_interface="in" units="per_ms" />
    <variable cmeta:id="CaRU_reduced_states.epsilon_pcc" name="epsilon_pcc" public_interface="in" units="per_ms" />
    <variable cmeta:id="CaRU_reduced_states.epsilon_pco" name="epsilon_pco" public_interface="in" units="per_ms" />
    <variable cmeta:id="CaRU_reduced_states.y_cc" name="y_cc" public_interface="in" units="dimensionless" />
    <math xmlns="http://www.w3.org/1998/Math/MathML">
      <apply>
        <eq />
        <ci>r_1</ci>
        <apply>
          <plus />
          <apply>
            <times />
            <ci>y_oc</ci>
            <ci>mu_poc</ci>
          </apply>
          <apply>
            <times />
            <ci>y_cc</ci>
            <ci>mu_pcc</ci>
          </apply>
        </apply>
      </apply>
      <apply>
        <eq />
        <ci>r_2</ci>
        <apply>
          <divide />
          <apply>
            <plus />
            <apply>
              <times />
              <ci>alpha_p</ci>
              <ci>mu_moc</ci>
            </apply>
            <apply>
              <times />
              <ci>alpha_m</ci>
              <ci>mu_mcc</ci>
            </apply>
          </apply>
          <apply>
            <plus />
            <ci>alpha_p</ci>
            <ci>alpha_m</ci>
          </apply>
        </apply>
      </apply>
      <apply>
        <eq />
        <ci>r_3</ci>
        <apply>
          <divide />
          <apply>
            <times />
            <ci>beta_m</ci>
            <ci>mu_pcc</ci>
          </apply>
          <apply>
            <plus />
            <ci>beta_m</ci>
            <ci>beta_pcc</ci>
          </apply>
        </apply>
      </apply>
      <apply>
        <eq />
        <ci>r_4</ci>
        <ci>mu_mcc</ci>
      </apply>
      <apply>
        <eq />
        <ci>r_5</ci>
        <apply>
          <plus />
          <apply>
            <times />
            <ci>y_co</ci>
            <ci>epsilon_pco</ci>
          </apply>
          <apply>
            <times />
            <ci>y_cc</ci>
            <ci>epsilon_pcc</ci>
          </apply>
        </apply>
      </apply>
      <apply>
        <eq />
        <ci>r_6</ci>
        <ci>epsilon_m</ci>
      </apply>
      <apply>
        <eq />
        <ci>r_7</ci>
        <apply>
          <divide />
          <apply>
            <times />
            <ci>alpha_m</ci>
            <ci>epsilon_pcc</ci>
          </apply>
          <apply>
            <plus />
            <ci>alpha_p</ci>
            <ci>alpha_m</ci>
          </apply>
        </apply>
      </apply>
      <apply>
        <eq />
        <ci>r_8</ci>
        <ci>epsilon_m</ci>
      </apply>
      <apply>
        <eq />
        <ci>z_4</ci>
        <apply>
          <minus />
          <apply>
            <minus />
            <apply>
              <minus />
              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
              <ci>z_1</ci>
            </apply>
            <ci>z_2</ci>
          </apply>
          <ci>z_3</ci>
        </apply>
      </apply>
      <apply>
        <eq />
        <apply>
          <diff />
          <bvar>
            <ci>time</ci>
          </bvar>
          <ci>z_1</ci>
        </apply>
        <apply>
          <plus />
          <apply>
            <times />
            <apply>
              <minus />
              <apply>
                <plus />
                <ci>r_1</ci>
                <ci>r_5</ci>
              </apply>
            </apply>
            <ci>z_1</ci>
          </apply>
          <apply>
            <times />
            <ci>r_2</ci>
            <ci>z_2</ci>
          </apply>
          <apply>
            <times />
            <ci>r_6</ci>
            <ci>z_3</ci>
          </apply>
        </apply>
      </apply>
      <apply>
        <eq />
        <apply>
          <diff />
          <bvar>
            <ci>time</ci>
          </bvar>
          <ci>z_2</ci>
        </apply>
        <apply>
          <plus />
          <apply>
            <minus />
            <apply>
              <times />
              <ci>r_1</ci>
              <ci>z_1</ci>
            </apply>
            <apply>
              <times />
              <apply>
                <plus />
                <ci>r_2</ci>
                <ci>r_7</ci>
              </apply>
              <ci>z_2</ci>
            </apply>
          </apply>
          <apply>
            <times />
            <ci>r_8</ci>
            <ci>z_4</ci>
          </apply>
        </apply>
      </apply>
      <apply>
        <eq />
        <apply>
          <diff />
          <bvar>
            <ci>time</ci>
          </bvar>
          <ci>z_3</ci>
        </apply>
        <apply>
          <plus />
          <apply>
            <minus />
            <apply>
              <times />
              <ci>r_5</ci>
              <ci>z_1</ci>
            </apply>
            <apply>
              <times />
              <apply>
                <plus />
                <ci>r_6</ci>
                <ci>r_3</ci>
              </apply>
              <ci>z_3</ci>
            </apply>
          </apply>
          <apply>
            <times />
            <ci>r_4</ci>
            <ci>z_4</ci>
          </apply>
        </apply>
      </apply>
    </math>
  </component>
  <group>
    <relationship_ref relationship="containment" />
    <component_ref component="membrane">
      <component_ref component="calmodulin_Ca_buffer" />
      <component_ref component="CaRU">
        <component_ref component="LCC_current" />
        <component_ref component="DS_Calcium_Concentrations" />
        <component_ref component="CaRU_Transitions" />
        <component_ref component="CaRU_reduced_states" />
        <component_ref component="RyR_current" />
        <component_ref component="CaRU_states" />
        <component_ref component="LCC_and_RyR_fluxes" />
      </component_ref>
      <component_ref component="Background_Ca_current" />
      <component_ref component="extracellular_ion_concentrations" />
      <component_ref component="intracellular_ion_concentrations" />
      <component_ref component="Na_Ca_Exchanger" />
      <component_ref component="cell_geometry" />
      <component_ref component="Sarcolemmal_Ca_pump" />
      <component_ref component="SR_Ca_leak_current" />
      <component_ref component="SERCA" />
      <component_ref component="troponin_Ca_buffer" />
    </component_ref>
  </group>
  <group>
    <relationship_ref relationship="encapsulation" />
    <component_ref component="CaRU">
      <component_ref component="LCC_current" />
      <component_ref component="DS_Calcium_Concentrations" />
      <component_ref component="CaRU_Transitions" />
      <component_ref component="CaRU_reduced_states" />
      <component_ref component="RyR_current" />
      <component_ref component="CaRU_states" />
      <component_ref component="LCC_and_RyR_fluxes" />
    </component_ref>
  </group>
  <connection>
    <map_components component_1="CaRU" component_2="CaRU_reduced_states" />
    <map_variables variable_1="time" variable_2="time" />
  </connection>
  <connection>
    <map_components component_1="Sarcolemmal_Ca_pump" component_2="convert_hinch" />
    <map_variables variable_1="I_pCa" variable_2="hinch_I_pCa" />
  </connection>
  <connection>
    <map_components component_1="extracellular_ion_concentrations" component_2="Na_Ca_Exchanger" />
    <map_variables variable_1="Na_o" variable_2="Na_o" />
    <map_variables variable_1="Ca_o" variable_2="Ca_o" />
  </connection>
  <connection>
    <map_components component_1="intracellular_ion_concentrations" component_2="calmodulin_Ca_buffer" />
    <map_variables variable_1="Ca_i" variable_2="Ca_i" />
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              <semsim:name>Total ionic flow through ryanodine receptor</semsim:name>
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    <rdf:Description rdf:about="#CaRU_states.y_io">
      <dcterms:description>The state of the calcium (2+) release unit when the L-type calcium channel is in the inactivated state and the ryanodine receptor is in the open state</dcterms:description>
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    <rdf:Description rdf:about="#CaRU_states.y_cc">
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      <dcterms:description>Convenience term for expressing equation for I_LCC?</dcterms:description>
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      <dcterms:description>Transition rate for three-state model of the ryanodine receptor when L-type calcium channel is open and ryanodine receptor is closed</dcterms:description>
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      <dcterms:description>Voltage across cell membrane</dcterms:description>
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    <rdf:Description rdf:about="#LCC_current.J_Loc">
      <dcterms:description>Current through the L-type calcium channel when L-type calcium channel state is open and ryanodine receptor state is closed</dcterms:description>
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      <bqs:reference>
        <rdf:Description rdf:about="rdf:#2705de26-2a37-49d6-9c76-4f5403abd457" bqs:Pubmed_id="15465866">
          <bqs:JournalArticle>
            <rdf:Description rdf:about="rdf:#9fc576f8-fb37-4824-b806-f91c4ea89ce3" bqs:volume="87(6)" bqs:first_page="3723" bqs:last_page="3736">
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              <dc:title>A Simplified Local Control Model of Calcium-Induced Calcium Release in Cardiac Ventricular Myocytes</dc:title>
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                  <dc:title>Biophysical Journal</dc:title>
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                  <dcterms:W3CDTF>2004-12-01 00:00</dcterms:W3CDTF>
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            <rdf:Bag>
              <rdf:li>ventricular myocyte</rdf:li>
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              <rdf:li>calcium</rdf:li>
              <rdf:li>electrophysiology</rdf:li>
              <rdf:li>cardiac</rdf:li>
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      <dcterms:description>Intracellular calcium (2+) concentration</dcterms:description>
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      <dcterms:description>Permeability of a single ryanodine receptor</dcterms:description>
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      <dcterms:description>Binding rate of calcium (2+) to troponin</dcterms:description>
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      <dcterms:description>Pump rate of sodium-calcium exchanger. Used to balance transmembrane flux of calcium(2+) over each cycle.</dcterms:description>
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      <dcterms:description>Transition rate for three-state model of the L-type calcium channel</dcterms:description>
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    <rdf:Description rdf:about="#Na_Ca_Exchanger.K_mCa">
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      <dcterms:description>Calcium (2+) half saturation of sodium-calcium exchanger</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="#CaRU_states.beta_pcc">
      <dcterms:description>Transition rate for three-state model of the ryanodine receptor when both the L-type calcium channel and ryanodine receptor are closed</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="#CaRU_reduced_states.y_oc">
      <dcterms:description>The state of the calcium (2+) release unit when the L-type calcium channel is in the open state and the ryanodine receptor is in the closed state</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="#troponin_Ca_buffer.k_m_TRPN">
      <dcterms:description>Dissociation rate of calcium (2+) from troponin</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="#CaRU_states.y_oc">
      <dcterms:description>The state of the calcium (2+) release unit when the L-type calcium channel is in the open state and the ryanodine receptor is in the closed state</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="#CaRU_Transitions.tau_L">
      <dcterms:description>Inactivation time for L-type calcium channels</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="#LCC_and_RyR_fluxes.Ca_SR">
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      </semsim:isComputationalComponentFor>
      <dcterms:description>Calcium (2+) concentration in sarcoplasmic reticulum</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="#convert_hinch.hinch_I_pCa">
      <semsim:isComputationalComponentFor>
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              <semsim:hasSourceParticipant>
                <rdf:Description rdf:about="#source_2" semsim:hasMultiplier="1.0">
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              </semsim:hasSourceParticipant>
              <semsim:name>Sarcolemmal calcium-ATPase flow</semsim:name>
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      <dcterms:description>Sarcolemmal calcium-ATPase flow</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="#CaRU_Transitions.alpha_m">
      <dcterms:description>Transition rate for three-state model of the L-type calcium channel</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="#CaRU_reduced_states.mu_poc">
      <dcterms:description>Transition rate for three-state model of the ryanodine receptor</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="#RyR_current.J_R1">
      <dcterms:description>Convenience term for expressing I_RyR equation?</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="#RyR_current.J_R3">
      <dcterms:description>Convenience term for expressing I_RyR equation?</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="http://www.cellml.org/cellml/1.0">
      <dc:publisher>University of Auckland</dc:publisher>
      <cmeta:comment>
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      </cmeta:comment>
      <dcterms:created rdf:resource="rdf:#c2adc79c-4f00-435b-a7c4-d6f862285665" dcterms:W3CDTF="2007-12-20T00:00:00+00:00" />
      <dc:creator>
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          <vCard:ORG>
            <rdf:Description rdf:about="rdf:#6e75de51-7dfc-4788-9fcd-5f8e41c57598">
              <vCard:Orgname>Auckland Bioengineering Institute</vCard:Orgname>
              <vCard:Orgunit>Systems Biology Group</vCard:Orgunit>
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          </vCard:ORG>
          <vCard:EMAIL rdf:resource="rdf:#62d8b973-47a8-44fe-b04d-eaefa203a1cb" rdf:value="j.terkildsen@auckland.ac.nz" rdf:type="http://imc.org/vCard/3.0#internet" />
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      </dc:creator>
      <cmeta:modification>
        <rdf:Description rdf:about="rdf:#6f2c694c-ac70-41f5-a2cc-211adc09e0af">
          <dcterms:modified rdf:resource="rdf:#58790332-40c9-4e31-a568-80c4672df9bd" dcterms:W3CDTF="2008-08-04T15:07:01+12:00" />
          <rdf:value>added cmeta:ids to some variables</rdf:value>
          <cmeta:modifier>
            <rdf:Description rdf:about="rdf:#098631b0-f9dd-458a-a5b3-8cb31b078889">
              <vCard:N rdf:resource="rdf:#219f0c72-a79a-432f-90e1-9feea33c5955" vCard:Given="James" vCard:Family="Lawson" vCard:Other="Richard" />
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          </cmeta:modifier>
        </rdf:Description>
      </cmeta:modification>
      <cmeta:modification>
        <rdf:Description rdf:about="rdf:#bf9f836f-d1cc-496e-b5a3-d27bca2a612c">
          <dcterms:modified rdf:resource="rdf:#6f58c9e7-80f2-4129-bf44-5ca37b965225" dcterms:W3CDTF="2007-12-20T15:28:34+13:00" />
          <rdf:value>This model runs in both COR and PCEnv.</rdf:value>
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          </cmeta:modifier>
        </rdf:Description>
      </cmeta:modification>
    </rdf:Description>
    <rdf:Description rdf:about="#Background_Ca_current_I_CaB">
      <semsim:isComputationalComponentFor>
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                </rdf:Description>
              </semsim:hasSourceParticipant>
              <semsim:name>Sarcolemmal calcium leak flow</semsim:name>
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        </rdf:Description>
      </semsim:isComputationalComponentFor>
      <dcterms:description>Sarcolemmal calcium leak current</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="#intracellular_ion_concentrations.I_SERCA">
      <semsim:isComputationalComponentFor>
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              <semsim:name>Calcium flow into the sarcoplasmic reticulum via SERCA pump</semsim:name>
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      <dcterms:description>Calcium (2+) resequestering into the sarcoplasmic reticulum via the sarco/endoplasmic reticulum Ca2+ -ATPase (SERCA) pump</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="#LCC_current.y_oo">
      <dcterms:description>The state of the calcium (2+) release unit when both the L-type calcium channel and the ryanodine receptor are in the open state</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="#CaRU_reduced_states.epsilon_pcc">
      <dcterms:description>Transition rate for three-state model of the L-type calcium channel</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="#LCC_and_RyR_fluxes.g_D">
      <dcterms:description>Calcium (2+) flux rate from dyadic space to cytosol</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="#SERCA.g_SERCA">
      <dcterms:description>Maximum pump rate of sarco/endoplasmic reticulum Ca2+ -ATPase (SERCA) pump</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="#membrane.R">
      <bqbiol:is rdf:resource="http://identifiers.org/opb/OPB_00410" />
      <dcterms:description>Universal gas constant</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="#LCC_and_RyR_fluxes.J_Rco">
      <dcterms:description>Current through the ryanodine receptor when L-type calcium channel state is closed and ryanodine receptor state is open</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="#calmodulin_Ca_buffer.B_CMDN">
      <semsim:isComputationalComponentFor>
        <rdf:Description rdf:about="#property_23">
          <semsim:physicalPropertyOf>
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              <ro:part_of rdf:resource="#entity_1" />
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          <semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_00340" />
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      </semsim:isComputationalComponentFor>
      <dcterms:description>Total cytosolic calmodulin concentration</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="#DS_Calcium_Concentrations.g_D">
      <dcterms:description>Calcium (2+) flux rate from dyadic space to cytosol</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="#CaRU_reduced_states.y_co">
      <dcterms:description>The state of the calcium (2+) release unit when the L-type calcium channel is in the closed state and the ryanodine receptor is in the open state</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="#CaRU_states.y_co">
      <dcterms:description>The state of the calcium (2+) release unit when the L-type calcium channel is in the closed state and the ryanodine receptor is in the open state</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="#CaRU_Transitions.alpha_p">
      <dcterms:description>Transition rate for three-state model of the L-type calcium channel</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="#CaRU_reduced_states.beta_m">
      <dcterms:description>Transition rate for three-state model of the ryanodine receptor</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="#convert_hinch.I_pCa">
      <semsim:isComputationalComponentFor>
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          <semsim:physicalPropertyOf rdf:resource="#process_1" />
          <semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_00318" />
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      </semsim:isComputationalComponentFor>
      <dcterms:description>Sarcolemmal calcium-ATPase flow (in uA)</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="#convert_hinch.I_CaB">
      <semsim:isComputationalComponentFor>
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          <semsim:physicalPropertyOf rdf:resource="#process_4" />
          <semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_00318" />
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      </semsim:isComputationalComponentFor>
      <dcterms:description>Sarcolemmal calcium leak current (in uA)</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="#CaRU_states.denom">
      <dcterms:description>Convenience term for computing ycc, yco, yoc, and yoo variables</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="#Na_Ca_Exchanger.k_sat">
      <dcterms:description>Low potential saturation factor of sodium-calcium exchanger</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="#Background_Ca_current.F">
      <bqbiol:is rdf:resource="http://identifiers.org/opb/OPB_00089" />
      <dcterms:description>Faraday constant</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="#CaRU_reduced_states.epsilon_pco">
      <dcterms:description>Transition rate for three-state model of the L-type calcium channel</dcterms:description>
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    <rdf:Description rdf:about="#calmodulin_Ca_buffer.Ca_i">
      <semsim:isComputationalComponentFor>
        <rdf:Description rdf:about="#property_24">
          <semsim:physicalPropertyOf rdf:resource="#entity_7" />
          <semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_00340" />
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      </semsim:isComputationalComponentFor>
      <dcterms:description>Intracellular calcium (2+) concentration</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="#CaRU_reduced_states.alpha_m">
      <dcterms:description>Transition rate for three-state model of the L-type calcium channel</dcterms:description>
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    <rdf:Description rdf:about="#Na_Ca_Exchanger.Na_o">
      <semsim:isComputationalComponentFor>
        <rdf:Description rdf:about="#property_6">
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          <semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_00340" />
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      </semsim:isComputationalComponentFor>
      <dcterms:description>Extracellular sodium (1+) concentration</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="#intracellular_ion_concentrations.time">
      <bqbiol:is rdf:resource="http://identifiers.org/opb/OPB_01023" />
      <dcterms:description>Simulation time domain</dcterms:description>
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    <rdf:Description rdf:about="#extracellular_ion_concentrations.Na_o">
      <semsim:isComputationalComponentFor>
        <rdf:Description rdf:about="#property_21">
          <semsim:physicalPropertyOf rdf:resource="#entity_6" />
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      </semsim:isComputationalComponentFor>
      <dcterms:description>Extracellular sodium (1+) concentration</dcterms:description>
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    <rdf:Description rdf:about="#RyR_current.N">
      <semsim:isComputationalComponentFor>
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          <semsim:physicalPropertyOf>
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              <semsim:name>Calcium release unit</semsim:name>
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          <semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_01001" />
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      <dcterms:description>Number of calcium release units</dcterms:description>
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    <rdf:Description rdf:about="#CaRU_Transitions.mu_pcc">
      <dcterms:description>Transition rate for three-state model of the ryanodine receptor</dcterms:description>
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    <rdf:Description rdf:about="#convert_hinch.V_myo">
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      <dcterms:description>Volume of myoplasm</dcterms:description>
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    <rdf:Description rdf:about="#troponin_Ca_buffer.Ca_i">
      <semsim:isComputationalComponentFor>
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      <dcterms:description>Intracellular calcium (2+) concentration</dcterms:description>
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    <rdf:Description rdf:about="#cell_geometry.V_SR">
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      <dcterms:description>Volume of sarcoplasmic reticulum</dcterms:description>
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    <rdf:Description rdf:about="#intracellular_ion_concentrations.I_RyR">
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      <dcterms:description>Total whole-cell current through the ryanodine receptors</dcterms:description>
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    <rdf:Description rdf:about="#convert_hinch.hinch_I_NaCa">
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      <dcterms:description>Sodium-calcium exchange current</dcterms:description>
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    <rdf:Description rdf:about="#membrane.F">
      <bqbiol:is rdf:resource="http://identifiers.org/opb/OPB_00089" />
      <dcterms:description>Faraday constant</dcterms:description>
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    <rdf:Description rdf:about="#CaRU_states.y_oi">
      <dcterms:description>The state of the calcium (2+) release unit when the L-type calcium channel is in the open state and the ryanodine receptor is in the inactivated state</dcterms:description>
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    <rdf:Description rdf:about="#Hinch_2004" bqmodel:isDescribedBy="15465866" semsim:modelName="Hinch_2004" />
    <rdf:Description rdf:about="#CaRU_Transitions.t_L">
      <dcterms:description>Time switching between closed and open states for L-type calcium channels</dcterms:description>
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    <rdf:Description rdf:about="#Background_Ca_current.R">
      <bqbiol:is rdf:resource="http://identifiers.org/opb/OPB_00410" />
      <dcterms:description>Universal gas constant</dcterms:description>
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    <rdf:Description rdf:about="#RyR_current.y_oc">
      <dcterms:description>The state of the calcium (2+) release unit when the L-type calcium channel is in the open state and the ryanodine receptor is in the closed state</dcterms:description>
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    <rdf:Description rdf:about="#Background_Ca_current.Ca_o">
      <semsim:isComputationalComponentFor>
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      <dcterms:description>Extracellular calcium (2+) concentration</dcterms:description>
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    <rdf:Description rdf:about="#LCC_and_RyR_fluxes.Ca_o">
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      <dcterms:description>Extracellular calcium (2+) concentration</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="#CaRU_reduced_states.z_1">
      <dcterms:description>State 1 of calcium release unit: z1 = ycc union yco union yoc union yoo</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="#CaRU.time">
      <bqbiol:is rdf:resource="http://identifiers.org/opb/OPB_01023" />
      <dcterms:description>Simulation time domain</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="#CaRU_Transitions.phi_R">
      <dcterms:description>Proportion of time closed in open mode for L-type calcium channels</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="#Na_Ca_Exchanger.FVRT">
      <dcterms:description>Convenience variable that is equal to F*V/(R*T)</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="#CaRU_reduced_states.epsilon_m">
      <dcterms:description>Transition rate for three-state model of the L-type calcium channel</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="#intracellular_ion_concentrations.I_NaCa">
      <semsim:isComputationalComponentFor>
        <rdf:Description rdf:about="#property_69">
          <semsim:physicalPropertyOf rdf:resource="#process_0" />
          <semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_00593" />
        </rdf:Description>
      </semsim:isComputationalComponentFor>
      <dcterms:description>Sodium-calcium exchange current</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="#LCC_current.z_2">
      <dcterms:description>State 2 of calcium release channel: z2 = yoi union yci</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="#cell_geometry.V_myo">
      <semsim:isComputationalComponentFor>
        <rdf:Description rdf:about="#property_85">
          <semsim:physicalPropertyOf rdf:resource="#entity_16" />
          <semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_00154" />
        </rdf:Description>
      </semsim:isComputationalComponentFor>
      <dcterms:description>Volume of myoplasm</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="#convert_hinch.hinch_I_CaB">
      <semsim:isComputationalComponentFor>
        <rdf:Description rdf:about="#property_40">
          <semsim:physicalPropertyOf rdf:resource="#process_4" />
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      </semsim:isComputationalComponentFor>
      <dcterms:description>Sarcolemmal calcium leak current</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="#membrane.FVRT_Ca">
      <dcterms:description>Convenience variable that is equal to (F*V/(R*T))*2. Also equivalent to [greek delta]*V in the source manuscript</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="#CaRU.J_R">
      <dcterms:description>Permeability of a single ryanodine receptor</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="#DS_Calcium_Concentrations.J_L">
      <dcterms:description>Permeability of a single L-type calcium channel</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="#DS_Calcium_Concentrations.C_oc">
      <semsim:isComputationalComponentFor>
        <rdf:Description rdf:about="#property_79">
          <semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_00340" />
        </rdf:Description>
      </semsim:isComputationalComponentFor>
      <dcterms:description>Concentration of calcium (2+) in the dyadic space when the L-type calcium channel state is open and the ryanodine receptor state is closed</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="#intracellular_ion_concentrations.V_myo">
      <semsim:isComputationalComponentFor>
        <rdf:Description rdf:about="#property_72">
          <semsim:physicalPropertyOf rdf:resource="#entity_16" />
          <semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_00154" />
        </rdf:Description>
      </semsim:isComputationalComponentFor>
      <dcterms:description>Volume of myoplasm</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="#LCC_and_RyR_fluxes.J_Roo">
      <dcterms:description>Current through the ryanodine receptor when both the L-type calcium channel and ryanodine receptor are in the open state</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="#CaRU_reduced_states.z_3">
      <dcterms:description>State 3 of calcium release unit: z3 = yic union yio</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="#Background_Ca_current.Ca_i">
      <semsim:isComputationalComponentFor>
        <rdf:Description rdf:about="#property_26">
          <semsim:physicalPropertyOf rdf:resource="#entity_7" />
          <semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_00340" />
        </rdf:Description>
      </semsim:isComputationalComponentFor>
      <dcterms:description>Intracellular calcium (2+) concentration</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="#CaRU_Transitions.beta_m">
      <dcterms:description>Transition rate for three-state model of the ryanodine receptor</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="#troponin_Ca_buffer.B_TRPN">
      <semsim:isComputationalComponentFor>
        <rdf:Description rdf:about="#property_46">
          <semsim:physicalPropertyOf>
            <rdf:Description rdf:about="#entity_19">
              <ro:part_of rdf:resource="#entity_16" />
              <semsim:name>Total bound and unbound troponin</semsim:name>
            </rdf:Description>
          </semsim:physicalPropertyOf>
          <semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_00340" />
        </rdf:Description>
      </semsim:isComputationalComponentFor>
      <dcterms:description>Total cytosolic troponin concentration</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="#CaRU_Transitions.tau_R">
      <dcterms:description>Inactivation time for ryanodine receptors</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="#DS_Calcium_Concentrations.J_R">
      <dcterms:description>Permeability of a single ryanodine receptor</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="#CaRU.I_LCC">
      <semsim:isComputationalComponentFor>
        <rdf:Description rdf:about="#property_13">
          <semsim:physicalPropertyOf rdf:resource="#process_3" />
          <semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_00593" />
        </rdf:Description>
      </semsim:isComputationalComponentFor>
      <dcterms:description>Total whole-cell current through the L-type calcium channels</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="#intracellular_ion_concentrations.beta_CMDN">
      <dcterms:description>Rapid buffer coeffiecient in the cytoplasm</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="#CaRU.J_L">
      <dcterms:description>Permeability of a single L-type calcium channel</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="#CaRU_reduced_states.z_2">
      <dcterms:description>State 2 of calcium release channel: z2 = yoi union yci</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="#process_7" dcterms:description="" />
    <rdf:Description rdf:about="#CaRU_Transitions.b">
      <dcterms:description>Biasing to make inactivation a function of membrane voltage</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="#Sarcolemmal_Ca_pump.K_mpCa">
      <semsim:isComputationalComponentFor>
        <rdf:Description rdf:about="#property_7">
          <semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_00340" />
        </rdf:Description>
      </semsim:isComputationalComponentFor>
      <dcterms:description>Half saturation of sarcolemmal pump</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="#CaRU.Ca_i">
      <semsim:isComputationalComponentFor>
        <rdf:Description rdf:about="#property_15">
          <semsim:physicalPropertyOf rdf:resource="#entity_7" />
          <semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_00340" />
        </rdf:Description>
      </semsim:isComputationalComponentFor>
      <dcterms:description>Intracellular calcium (2+) concentration</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="#CaRU_Transitions.C_oc">
      <semsim:isComputationalComponentFor>
        <rdf:Description rdf:about="#property_59">
          <semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_00340" />
        </rdf:Description>
      </semsim:isComputationalComponentFor>
      <dcterms:description>Concentration of calcium (2+) in the dyadic space when the L-type calcium channel state is open and the ryanodine receptor state is closed</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="#CaRU_states.beta_m">
      <dcterms:description>Transition rate for three-state model of the ryanodine receptor</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="#Background_Ca_current.E_Ca">
      <semsim:isComputationalComponentFor>
        <rdf:Description rdf:about="#property_27">
          <semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_00506" />
        </rdf:Description>
      </semsim:isComputationalComponentFor>
      <dcterms:description>Reversal potential for sarcolemmal leak current</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="#CaRU.FVRT_Ca">
      <dcterms:description>Convenience variable that is equal to (F*V/(R*T))*2. Also equivalent to [greek delta]*V in the source manuscript</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="#CaRU_Transitions.epsilon_m">
      <dcterms:description>Transition rate for three-state model of the L-type calcium channel</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="#CaRU_reduced_states.alpha_p">
      <dcterms:description>Transition rate for three-state model of the L-type calcium channel</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="#CaRU_Transitions.a">
      <dcterms:description>Biasing to make inactivation a function of membrane voltage</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="#intracellular_ion_concentrations.I_SR">
      <semsim:isComputationalComponentFor>
        <rdf:Description rdf:about="#property_71">
          <semsim:physicalPropertyOf rdf:resource="#process_5" />
          <semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_00593" />
        </rdf:Description>
      </semsim:isComputationalComponentFor>
      <dcterms:description>Calcium (2+) leak from the sarcoplasmic reticulum to the bulk myoplasm</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="#LCC_current_I_LCC">
      <semsim:isComputationalComponentFor>
        <rdf:Description rdf:about="#property_54">
          <semsim:physicalPropertyOf rdf:resource="#process_3" />
          <semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_00593" />
        </rdf:Description>
      </semsim:isComputationalComponentFor>
      <dcterms:description>Total whole-cell current through the L-type calcium channels</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="#CaRU_reduced_states.z_4">
      <dcterms:description>State 4 of calcium release unit: z4 = yii</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="#CaRU_Transitions.t_R">
      <dcterms:description>Time switching between closed and open states for ryanodine receptors</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="#CaRU_Transitions.K_L">
      <semsim:isComputationalComponentFor>
        <rdf:Description rdf:about="#property_61">
          <semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_00340" />
        </rdf:Description>
      </semsim:isComputationalComponentFor>
      <dcterms:description>Concentration of L-type calcium channels at inactivation</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="#CaRU_states.y_ic">
      <dcterms:description>The state of the calcium (2+) release unit when the L-type calcium channel is in the inactivated state and the ryanodine receptor is in the closed state</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="#CaRU_states.y_oo">
      <dcterms:description>The state of the calcium (2+) release unit when both the L-type calcium channel and the ryanodine receptor are in the open state</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="#intracellular_ion_concentrations.Ca_SR">
      <semsim:isComputationalComponentFor>
        <rdf:Description rdf:about="#property_65">
          <semsim:physicalPropertyOf rdf:resource="#entity_12" />
          <semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_00340" />
        </rdf:Description>
      </semsim:isComputationalComponentFor>
      <dcterms:description>Calcium (2+) concentration in sarcoplasmic reticulum</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="#CaRU_Transitions.V_L">
      <dcterms:description>Potential when half LCC open</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="#SERCA_I_SERCA">
      <semsim:isComputationalComponentFor>
        <rdf:Description rdf:about="#property_58">
          <semsim:physicalPropertyOf rdf:resource="#process_6" />
          <semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_00593" />
        </rdf:Description>
      </semsim:isComputationalComponentFor>
      <dcterms:description>Calcium (2+) resequestering into the sarcoplasmic reticulum via the sarco/endoplasmic reticulum Ca2+ -ATPase (SERCA) pump</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="#SERCA.K_SERCA">
      <semsim:isComputationalComponentFor>
        <rdf:Description rdf:about="#property_56">
          <semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_00340" />
        </rdf:Description>
      </semsim:isComputationalComponentFor>
      <dcterms:description>Half saturation of sarco/endoplasmic reticulum Ca2+ -ATPase (SERCA) pump</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="#convert_hinch.hinch_I_RyR">
      <semsim:isComputationalComponentFor>
        <rdf:Description rdf:about="#property_38">
          <semsim:physicalPropertyOf rdf:resource="#process_2" />
          <semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_00593" />
        </rdf:Description>
      </semsim:isComputationalComponentFor>
      <dcterms:description>Total whole-cell current through the ryanodine receptors</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="#SERCA.Ca_i">
      <semsim:isComputationalComponentFor>
        <rdf:Description rdf:about="#property_57">
          <semsim:physicalPropertyOf rdf:resource="#entity_7" />
          <semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_00340" />
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      </semsim:isComputationalComponentFor>
      <dcterms:description>Intracellular calcium (2+) concentration</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="#intracellular_ion_concentrations_Ca_i">
      <semsim:isComputationalComponentFor>
        <rdf:Description rdf:about="#property_66">
          <semsim:physicalPropertyOf rdf:resource="#entity_7" />
          <semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_00340" />
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      </semsim:isComputationalComponentFor>
      <dcterms:description>Intracellular calcium (2+) concentration</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="#CaRU_reduced_states.mu_mcc">
      <dcterms:description>Transition rate for three-state model of the ryanodine receptor</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="#CaRU_Transitions.C_co">
      <semsim:isComputationalComponentFor>
        <rdf:Description rdf:about="#property_62">
          <semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_00340" />
        </rdf:Description>
      </semsim:isComputationalComponentFor>
      <dcterms:description>Concentration of calcium (2+) in dyadic space when L-type calcium channel state is closed and when ryanodine receptor state is open</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="#membrane.time">
      <bqbiol:is rdf:resource="http://identifiers.org/opb/OPB_01023" />
      <dcterms:description>Simulation time domain</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="#CaRU_reduced_states.r_1">
      <dcterms:description>Rate constant for transition of calcium release unit from state 1 to state 2</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="#LCC_current.alpha_p">
      <dcterms:description>Transition rate for three-state model of the L-type calcium channel</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="#LCC_and_RyR_fluxes.J_Loc">
      <dcterms:description>Current through the L-type calcium channel when L-type calcium channel state is open and ryanodine receptor state is closed</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="#Na_Ca_Exchanger.Na_i">
      <semsim:isComputationalComponentFor>
        <rdf:Description rdf:about="#property_1">
          <semsim:physicalPropertyOf rdf:resource="#entity_0" />
          <semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_00340" />
        </rdf:Description>
      </semsim:isComputationalComponentFor>
      <dcterms:description>Intracellular sodium (1+) concentration</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="#RyR_current.J_Roo">
      <dcterms:description>Current through the ryanodine receptor when both the L-type calcium channel and ryanodine receptor are in the open state</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="#RyR_current.z_3">
      <dcterms:description>State 3 of calcium release unit: z3 = yic union yio</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="#CaRU_Transitions.epsilon_pco">
      <dcterms:description>Transition rate for three-state model of the L-type calcium channel</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="#CaRU_Transitions.V">
      <semsim:isComputationalComponentFor>
        <rdf:Description rdf:about="#property_60">
          <semsim:physicalPropertyOf rdf:resource="#entity_11" />
          <semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_00506" />
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      </semsim:isComputationalComponentFor>
      <dcterms:description>Voltage across cell membrane</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="#DS_Calcium_Concentrations.Ca_o">
      <semsim:isComputationalComponentFor>
        <rdf:Description rdf:about="#property_80">
          <semsim:physicalPropertyOf rdf:resource="#entity_3" />
          <semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_00340" />
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      </semsim:isComputationalComponentFor>
      <dcterms:description>Extracellular calcium (2+) concentration</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="#Na_Ca_Exchanger.Ca_i">
      <semsim:isComputationalComponentFor>
        <rdf:Description rdf:about="#property_5">
          <semsim:physicalPropertyOf rdf:resource="#entity_7" />
          <semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_00340" />
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      </semsim:isComputationalComponentFor>
      <dcterms:description>Intracellular calcium (2+) concentration</dcterms:description>
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    <rdf:Description rdf:about="#intracellular_ion_concentrations_CaSR_plot">
      <semsim:isComputationalComponentFor>
        <rdf:Description rdf:about="#property_67">
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      <dcterms:description>Concentration of sarcoplasmic calcium normalized to cytosolic volume (presumably for comparing simulation results to Figure 7B of reference publication).</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="#RyR_current.z_1">
      <dcterms:description>State 1 of calcium release unit: z1 = ycc union yco union yoc union yoo</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="#Na_Ca_Exchanger_I_NaCa">
      <semsim:isComputationalComponentFor>
        <rdf:Description rdf:about="#property_3">
          <semsim:physicalPropertyOf rdf:resource="#process_0" />
          <semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_00593" />
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      <dcterms:description>Sodium-calcium exchange current</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="#CaRU_Transitions.mu_poc">
      <dcterms:description>Transition rate for three-state model of the ryanodine receptor</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="#CaRU_states.alpha_m">
      <dcterms:description>Transition rate for three-state model of the L-type calcium channel</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="#LCC_current.z_1">
      <dcterms:description>State 1 of calcium release unit: z1 = ycc union yco union yoc union yoo</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="#Background_Ca_current.g_CaB">
      <dcterms:description>Conductance of background calcium (2+) current</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="#CaRU_reduced_states.r_3">
      <dcterms:description>Rate constant for transition of calcium release unit from state 3 to state 4</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="#CaRU.V_myo">
      <semsim:isComputationalComponentFor>
        <rdf:Description rdf:about="#property_17">
          <semsim:physicalPropertyOf rdf:resource="#entity_16" />
          <semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_00154" />
        </rdf:Description>
      </semsim:isComputationalComponentFor>
      <dcterms:description>Volume of myoplasm</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="#Background_Ca_current.T">
      <semsim:isComputationalComponentFor>
        <rdf:Description rdf:about="#property_28">
          <semsim:physicalPropertyOf rdf:resource="#entity_5" />
          <semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_00293" />
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      <dcterms:description>Ambient temperature</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="#CaRU.N">
      <semsim:isComputationalComponentFor>
        <rdf:Description rdf:about="#property_18">
          <semsim:physicalPropertyOf rdf:resource="#entity_17" />
          <semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_01001" />
        </rdf:Description>
      </semsim:isComputationalComponentFor>
      <dcterms:description>Number of calcium release units</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="#LCC_current.J_L2">
      <dcterms:description>Convenience term for expressing equation for I_LCC?</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="#convert_hinch.hinch_I_LCC">
      <semsim:isComputationalComponentFor>
        <rdf:Description rdf:about="#property_35">
          <semsim:physicalPropertyOf rdf:resource="#process_3" />
          <semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_00593" />
        </rdf:Description>
      </semsim:isComputationalComponentFor>
      <dcterms:description>Total whole-cell current through the L-type calcium channels</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="#CaRU_reduced_states.r_2">
      <dcterms:description>Rate constant for transition of calcium release unit from state 2 to state 1</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="#LCC_current.alpha_m">
      <dcterms:description>Transition rate for three-state model of the L-type calcium channel</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="#convert_hinch.I_RyR">
      <semsim:isComputationalComponentFor>
        <rdf:Description rdf:about="#property_39">
          <semsim:physicalPropertyOf rdf:resource="#process_2" />
          <semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_00593" />
        </rdf:Description>
      </semsim:isComputationalComponentFor>
      <dcterms:description>Total whole-cell current through the ryanodine receptors (in uA)</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="#DS_Calcium_Concentrations.C_cc">
      <semsim:isComputationalComponentFor>
        <rdf:Description rdf:about="#property_81">
          <semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_00340" />
        </rdf:Description>
      </semsim:isComputationalComponentFor>
      <dcterms:description>Concentration of calcium (2+) in dyadic space when both L-type calcium channel and ryanodine receptor states are closed</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="#CaRU_states.y_ii">
      <dcterms:description>The state of the calcium (2+) release unit when both the L-type calcium channel and the ryanodine receptor are in the inactivated state</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="#Background_Ca_current.V">
      <semsim:isComputationalComponentFor>
        <rdf:Description rdf:about="#property_25">
          <semsim:physicalPropertyOf rdf:resource="#entity_11" />
          <semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_00506" />
        </rdf:Description>
      </semsim:isComputationalComponentFor>
      <dcterms:description>Voltage across cell membrane</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="#CaRU_reduced_states.r_5">
      <dcterms:description>Rate constant for transition of calcium release unit from state 1 to state 3</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="#LCC_current.N">
      <semsim:isComputationalComponentFor>
        <rdf:Description rdf:about="#property_53">
          <semsim:physicalPropertyOf rdf:resource="#entity_17" />
          <semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_01001" />
        </rdf:Description>
      </semsim:isComputationalComponentFor>
      <dcterms:description>Number of calcium release units</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="#DS_Calcium_Concentrations.Ca_SR">
      <semsim:isComputationalComponentFor>
        <rdf:Description rdf:about="#property_78">
          <semsim:physicalPropertyOf rdf:resource="#entity_12" />
          <semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_00340" />
        </rdf:Description>
      </semsim:isComputationalComponentFor>
      <dcterms:description>Calcium (2+) concentration in sarcoplasmic reticulum</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="#intracellular_ion_concentrations.I_pCa">
      <semsim:isComputationalComponentFor>
        <rdf:Description rdf:about="#property_74">
          <semsim:physicalPropertyOf rdf:resource="#process_1" />
          <semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_00593" />
        </rdf:Description>
      </semsim:isComputationalComponentFor>
      <dcterms:description>Sarcolemmal calcium-ATPase flow</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="#SR_Ca_leak_current.Ca_i">
      <semsim:isComputationalComponentFor>
        <rdf:Description rdf:about="#property_50">
          <semsim:physicalPropertyOf rdf:resource="#entity_7" />
          <semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_00340" />
        </rdf:Description>
      </semsim:isComputationalComponentFor>
      <dcterms:description>Intracellular calcium (2+) concentration</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="#RyR_current.y_co">
      <dcterms:description>The state of the calcium (2+) release unit when the L-type calcium channel is in the closed state and the ryanodine receptor is in the open state</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="#RyR_current.V_myo">
      <semsim:isComputationalComponentFor>
        <rdf:Description rdf:about="#property_49">
          <semsim:physicalPropertyOf rdf:resource="#entity_16" />
          <semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_00154" />
        </rdf:Description>
      </semsim:isComputationalComponentFor>
      <dcterms:description>Volume of myoplasm</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="#CaRU_Transitions.del_VL">
      <dcterms:description>Width of opening potentials of L-type calcium channels</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="#RyR_current.beta_m">
      <dcterms:description>Transition rate for three-state model of the ryanodine receptor</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="#CaRU_reduced_states.r_4">
      <dcterms:description>Rate constant for transition of calcium release unit from state 4 to state 3</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="#Sarcolemmal_Ca_pump_I_pCa">
      <semsim:isComputationalComponentFor>
        <rdf:Description rdf:about="#property_9">
          <semsim:physicalPropertyOf rdf:resource="#process_1" />
          <semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_00593" />
        </rdf:Description>
      </semsim:isComputationalComponentFor>
      <dcterms:description>Sarcolemmal calcium-ATPase flow</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="#LCC_current.V_myo">
      <semsim:isComputationalComponentFor>
        <rdf:Description rdf:about="#property_55">
          <semsim:physicalPropertyOf rdf:resource="#entity_16" />
          <semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_00154" />
        </rdf:Description>
      </semsim:isComputationalComponentFor>
      <dcterms:description>Volume of myoplasm</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="#CaRU.I_RyR">
      <semsim:isComputationalComponentFor>
        <rdf:Description rdf:about="#property_12">
          <semsim:physicalPropertyOf rdf:resource="#process_2" />
          <semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_00593" />
        </rdf:Description>
      </semsim:isComputationalComponentFor>
      <dcterms:description>Total whole-cell current through the ryanodine receptors</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="#calmodulin_Ca_buffer.k_CMDN">
      <semsim:isComputationalComponentFor>
        <rdf:Description rdf:about="#property_22">
          <semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_00340" />
        </rdf:Description>
      </semsim:isComputationalComponentFor>
      <dcterms:description>Half saturation constant of calmodulin</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="#LCC_and_RyR_fluxes.FVRT_Ca">
      <dcterms:description>Convenience variable that is equal to (F*V/(R*T))*2. Also equivalent to [greek delta]*V in the source manuscript</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="#hinch_greenstein_tanskanen_xu_winslow_2004">
      <ro:located_in rdf:resource="http://purl.obolibrary.org/obo/FMA_9672" />
      <ro:compartmentOf rdf:resource="http://purl.obolibrary.org/obo/FMA_80352" />
      <ro:located_in rdf:resource="http://purl.obolibrary.org/obo/FMA_80352" />
      <ro:compartmentOf rdf:resource="http://purl.obolibrary.org/obo/FMA_66836" />
      <ro:located_in rdf:resource="http://purl.obolibrary.org/obo/FMA_66836" />
      <ro:located_in rdf:resource="http://purl.obolibrary.org/obo/FMA_9462" />
      <ro:located_in rdf:resource="http://purl.obolibrary.org/obo/FMA_14067" />
      <ro:compartmentOf rdf:resource="http://purl.obolibrary.org/obo/FMA_14067" />
      <ro:compartmentOf rdf:resource="http://purl.obolibrary.org/obo/FMA_67225" />
      <ro:located_in rdf:resource="http://purl.obolibrary.org/obo/FMA_84669" />
      <ro:compartmentOf rdf:resource="http://purl.obolibrary.org/obo/FMA_9462" />
      <ro:compartmentOf rdf:resource="http://purl.obolibrary.org/obo/FMA_9672" />
      <ro:compartmentOf rdf:resource="http://purl.obolibrary.org/obo/FMA_63841" />
      <ro:located_in rdf:resource="http://purl.obolibrary.org/obo/FMA_67225" />
      <ro:modelOf rdf:resource="http://purl.obolibrary.org/obo/CL_0000746" />
      <ro:located_in rdf:resource="http://purl.obolibrary.org/obo/FMA_63841" />
      <ro:compartmentOf rdf:resource="http://purl.obolibrary.org/obo/FMA_84669" />
    </rdf:Description>
    <rdf:Description rdf:about="#CaRU_Transitions.beta_pcc">
      <dcterms:description>Transition rate for three-state model of the ryanodine receptor when both the L-type calcium channel and ryanodine receptor are closed</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="#intracellular_ion_concentrations.I_CaB">
      <semsim:isComputationalComponentFor>
        <rdf:Description rdf:about="#property_68">
          <semsim:physicalPropertyOf rdf:resource="#process_4" />
          <semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_00593" />
        </rdf:Description>
      </semsim:isComputationalComponentFor>
      <dcterms:description>Sarcolemmal calcium leak current</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="#CaRU_reduced_states.time">
      <bqbiol:is rdf:resource="http://identifiers.org/opb/OPB_01023" />
      <dcterms:description>Simulation time domain</dcterms:description>
    </rdf:Description>
  </rdf:RDF>
</model>