Location: semantic-annotation @ 848b6a8fb585 / tran_smith_loiselle_crampin_2009.cellml

Author:
Dewan Sarwar <sarwarcse@gmail.com>
Date:
2019-01-31 16:34:20+13:00
Desc:
Testing with Max's suggested way of annotation for weinstein_1995_max model
Permanent Source URI:
https://models.physiomeproject.org/workspace/584/rawfile/848b6a8fb585337adc4f3805c0ed682a6a5fd379/tran_smith_loiselle_crampin_2009.cellml

<?xml version="1.0" encoding="UTF-8"?>
<model xmlns="http://www.cellml.org/cellml/1.1#" xmlns:cmeta="http://www.cellml.org/metadata/1.0#" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bqs="http://www.cellml.org/bqs/1.0#" xmlns:semsim="http://www.bhi.washington.edu/SemSim#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" name="tran_model_2009" cmeta:id="tran_model_2009">
  <documentation xmlns="http://cellml.org/tmp-documentation">
    <article>
      <articleinfo>
        <title>A Thermodynamic Model of the Cardiac Sarcoplasmic/Endoplasmic Ca(2+) (SERCA) Pump</title>
        <author>
          <firstname>Catherine</firstname>
          <surname>Lloyd</surname>
          <affiliation>
            <shortaffil>Auckland Bioengineering Institute, The University of Auckland</shortaffil>
          </affiliation>
        </author>
      </articleinfo>
      <section id="sec_status">
        <title>Model Status</title>
        <para>This CellML model has been unit checked and is known to run in both OpenCell and COR.  This particular version of the CellML model describes the three-state cooperative SERCA model and recreates figure 13.  In order to recreate this figure we have had to add an additional equation to the model to define the rate of change in Casr.  Please also note there are typographical errors in the original paper and [H+] should be raised to the power of n (n=2) for T_Hi and T_Hsr. Also in figure 12 the concentrations of ADP should be 8uM and 20uM rather than 20uM and 40uM.</para>
      </section>
      <sect1 id="sec_structure">
        <title>Model Structure</title>
        <para>ABSTRACT: We present a biophysically based kinetic model of the cardiac SERCA pump that consolidates a range of experimental data into a consistent and thermodynamically constrained framework. The SERCA model consists of a number of sub-states with partial reactions that are sensitive to Ca(2+) and pH, and to the metabolites MgATP, MgADP, and Pi. Optimization of model parameters to fit experimental data favors a fully cooperative Ca(2+)-binding mechanism and predicts a Ca(2+)/H(+) counter-transport stoichiometry of 2. Moreover, the order of binding of the partial reactions, particularly the binding of MgATP, proves to be a strong determinant of the ability of the model to fit the data. A thermodynamic investigation of the model indicates that the binding of MgATP has a large inhibitory effect on the maximal reverse rate of the pump. The model is suitable for integrating into whole-cell models of cardiac electrophysiology and Ca(2+) dynamics to simulate the effects on the cell of compromised metabolism arising in ischemia and hypoxia.</para>
        <para>The complete original paper reference is cited below:</para>
        <para>
          A Thermodynamic Model of the Cardiac Sarcoplasmic/Endoplasmic Ca(2+) (SERCA) Pump, Kenneth Tran, Nicolas P. Smith, Denis S. Loiselle, and Edmund J. Crampin, 2009,
          <emphasis>Biophysical Journal</emphasis>
          , 96 (5) 2029-2042.
          <ulink url="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&amp;cmd=Retrieve&amp;dopt=AbstractPlus&amp;list_uids=19254563&amp;query_hl=1&amp;itool=pubmed_docsum">PubMed ID: 19254563</ulink>
        </para>
        <informalfigure float="0">
          <mediaobject>
            <imageobject>
              <imagedata fileref="tran_2009.png" />
            </imageobject>
          </mediaobject>
          <caption>Schematic of the simplified three-state model. Application of the rapid equilibrium assumption to the ion-binding partial reactions (states within the two dotted boxes in Fig. 1) results in a simplified three-state model. The apparent rate constants (alphai + or -, i = 1, 2, 3) replace the forward and backward rate constants and are a function of ion concentrations and dissociation constants.</caption>
        </informalfigure>
      </sect1>
    </article>
  </documentation>
  <units name="first_order_rate_constant">
    <unit exponent="-1.0" units="second" />
  </units>
  <units name="millimolar_squared">
    <unit exponent="2.0" units="millimolar" />
  </units>
  <units name="per_second_squared">
    <unit exponent="-2.0" units="second" />
  </units>
  <units name="millimolar">
    <unit prefix="milli" units="mole" />
    <unit exponent="-1.0" units="litre" />
  </units>
  <units name="second_order_rate_constant">
    <unit exponent="-1.0" units="second" />
    <unit exponent="-1.0" units="millimolar" />
  </units>
  <component name="environment">
    <variable cmeta:id="environment_time" name="time" public_interface="out" units="second" />
  </component>
  <component name="SERCA">
    <variable cmeta:id="SERCA.T_H1" name="T_H1" units="dimensionless" />
    <variable cmeta:id="SERCA_Ca_i" name="Ca_i" units="millimolar" />
    <variable cmeta:id="SERCA.T_Cai" name="T_Cai" units="dimensionless" />
    <variable cmeta:id="SERCA.T_H" name="T_H" units="dimensionless" />
    <variable cmeta:id="SERCA.time" name="time" public_interface="in" units="second" />
    <variable cmeta:id="SERCA.T_Hsr" name="T_Hsr" units="dimensionless" />
    <variable cmeta:id="SERCA.k_m1" name="k_m1" units="first_order_rate_constant" />
    <variable cmeta:id="SERCA.k_m2" name="k_m2" units="second_order_rate_constant" />
    <variable cmeta:id="SERCA.k_m3" name="k_m3" units="second_order_rate_constant" />
    <variable cmeta:id="SERCA.a_m3" name="a_m3" units="first_order_rate_constant" />
    <variable cmeta:id="SERCA.a_m2" name="a_m2" units="first_order_rate_constant" />
    <variable cmeta:id="SERCA.a_m1" name="a_m1" units="first_order_rate_constant" />
    <variable cmeta:id="SERCA.kdh1" name="kdh1" units="millimolar" />
    <variable cmeta:id="SERCA.n" name="n" units="dimensionless" />
    <variable cmeta:id="SERCA.kdh" name="kdh" units="millimolar" />
    <variable cmeta:id="SERCA.a_p3" name="a_p3" units="first_order_rate_constant" />
    <variable cmeta:id="SERCA.a_p2" name="a_p2" units="first_order_rate_constant" />
    <variable cmeta:id="SERCA_H_i" name="H_i" units="millimolar" />
    <variable cmeta:id="SERCA_a_p1" name="a_p1" units="first_order_rate_constant" />
    <variable cmeta:id="SERCA_ATP" name="ATP" units="millimolar" />
    <variable cmeta:id="SERCA_P_i" name="P_i" units="millimolar" />
    <variable cmeta:id="SERCA.v_cycle" name="v_cycle" units="first_order_rate_constant" />
    <variable cmeta:id="SERCA.s1" name="s1" units="per_second_squared" />
    <variable cmeta:id="SERCA.s2" name="s2" units="per_second_squared" />
    <variable cmeta:id="SERCA.s3" name="s3" units="per_second_squared" />
    <variable cmeta:id="SERCA.k_p1" name="k_p1" units="second_order_rate_constant" />
    <variable cmeta:id="SERCA.k_p2" name="k_p2" units="first_order_rate_constant" />
    <variable cmeta:id="SERCA.k_p3" name="k_p3" units="first_order_rate_constant" />
    <variable cmeta:id="SERCA.kdhi" name="kdhi" units="millimolar_squared" />
    <variable cmeta:id="SERCA.kdcai" name="kdcai" units="millimolar" />
    <variable cmeta:id="SERCA.kdcasr" name="kdcasr" units="millimolar" />
    <variable cmeta:id="SERCA_Ca_sr" name="Ca_sr" units="millimolar" />
    <variable cmeta:id="SERCA.T_Casr" name="T_Casr" units="dimensionless" />
    <variable cmeta:id="SERCA_ADP" name="ADP" units="millimolar" />
    <variable cmeta:id="SERCA.T_Hi" name="T_Hi" units="dimensionless" />
    <variable cmeta:id="SERCA.kdhsr" name="kdhsr" units="millimolar_squared" />
    <math xmlns="http://www.w3.org/1998/Math/MathML">
      <apply>
        <eq />
        <ci>T_Cai</ci>
        <apply>
          <divide />
          <ci>Ca_i</ci>
          <ci>kdcai</ci>
        </apply>
      </apply>
      <apply>
        <eq />
        <ci>T_Casr</ci>
        <apply>
          <divide />
          <ci>Ca_sr</ci>
          <ci>kdcasr</ci>
        </apply>
      </apply>
      <apply>
        <eq />
        <ci>T_H1</ci>
        <apply>
          <divide />
          <ci>H_i</ci>
          <ci>kdh1</ci>
        </apply>
      </apply>
      <apply>
        <eq />
        <ci>T_Hi</ci>
        <apply>
          <divide />
          <apply>
            <power />
            <ci>H_i</ci>
            <ci>n</ci>
          </apply>
          <ci>kdhi</ci>
        </apply>
      </apply>
      <apply>
        <eq />
        <ci>T_Hsr</ci>
        <apply>
          <divide />
          <apply>
            <power />
            <ci>H_i</ci>
            <ci>n</ci>
          </apply>
          <ci>kdhsr</ci>
        </apply>
      </apply>
      <apply>
        <eq />
        <ci>T_H</ci>
        <apply>
          <divide />
          <ci>H_i</ci>
          <ci>kdh</ci>
        </apply>
      </apply>
      <apply>
        <eq />
        <ci>a_p1</ci>
        <apply>
          <times />
          <ci>k_p1</ci>
          <ci>ATP</ci>
        </apply>
      </apply>
      <apply>
        <eq />
        <ci>a_p2</ci>
        <apply>
          <divide />
          <apply>
            <times />
            <ci>k_p2</ci>
            <apply>
              <power />
              <ci>T_Cai</ci>
              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
            </apply>
          </apply>
          <apply>
            <plus />
            <apply>
              <power />
              <ci>T_Cai</ci>
              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
            </apply>
            <apply>
              <times />
              <apply>
                <power />
                <ci>T_Cai</ci>
                <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
              </apply>
              <ci>T_Hi</ci>
            </apply>
            <apply>
              <times />
              <ci>T_Hi</ci>
              <apply>
                <plus />
                <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                <ci>T_H1</ci>
              </apply>
            </apply>
          </apply>
        </apply>
      </apply>
      <apply>
        <eq />
        <ci>a_p3</ci>
        <apply>
          <divide />
          <apply>
            <times />
            <ci>k_p3</ci>
            <ci>T_Hsr</ci>
          </apply>
          <apply>
            <plus />
            <apply>
              <times />
              <apply>
                <power />
                <ci>T_Casr</ci>
                <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
              </apply>
              <ci>T_H</ci>
            </apply>
            <ci>T_H</ci>
            <apply>
              <times />
              <ci>T_Hsr</ci>
              <apply>
                <plus />
                <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                <ci>T_H</ci>
              </apply>
            </apply>
          </apply>
        </apply>
      </apply>
      <apply>
        <eq />
        <ci>a_m1</ci>
        <apply>
          <divide />
          <apply>
            <times />
            <ci>k_m1</ci>
            <ci>T_Hi</ci>
          </apply>
          <apply>
            <plus />
            <apply>
              <power />
              <ci>T_Cai</ci>
              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
            </apply>
            <apply>
              <times />
              <apply>
                <power />
                <ci>T_Cai</ci>
                <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
              </apply>
              <ci>T_Hi</ci>
            </apply>
            <apply>
              <times />
              <ci>T_Hi</ci>
              <apply>
                <plus />
                <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                <ci>T_H1</ci>
              </apply>
            </apply>
          </apply>
        </apply>
      </apply>
      <apply>
        <eq />
        <ci>a_m2</ci>
        <apply>
          <divide />
          <apply>
            <times />
            <ci>k_m2</ci>
            <ci>ADP</ci>
            <apply>
              <power />
              <ci>T_Casr</ci>
              <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
            </apply>
            <ci>T_H</ci>
          </apply>
          <apply>
            <plus />
            <apply>
              <times />
              <apply>
                <power />
                <ci>T_Casr</ci>
                <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2</cn>
              </apply>
              <ci>T_H</ci>
            </apply>
            <ci>T_H</ci>
            <apply>
              <times />
              <ci>T_Hsr</ci>
              <apply>
                <plus />
                <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                <ci>T_H</ci>
              </apply>
            </apply>
          </apply>
        </apply>
      </apply>
      <apply>
        <eq />
        <ci>a_m3</ci>
        <apply>
          <times />
          <ci>k_m3</ci>
          <ci>P_i</ci>
        </apply>
      </apply>
      <apply>
        <eq />
        <ci>s1</ci>
        <apply>
          <plus />
          <apply>
            <times />
            <ci>a_p2</ci>
            <ci>a_p3</ci>
          </apply>
          <apply>
            <times />
            <ci>a_m1</ci>
            <ci>a_p3</ci>
          </apply>
          <apply>
            <times />
            <ci>a_m1</ci>
            <ci>a_m2</ci>
          </apply>
        </apply>
      </apply>
      <apply>
        <eq />
        <ci>s2</ci>
        <apply>
          <plus />
          <apply>
            <times />
            <ci>a_p1</ci>
            <ci>a_p3</ci>
          </apply>
          <apply>
            <times />
            <ci>a_m2</ci>
            <ci>a_p1</ci>
          </apply>
          <apply>
            <times />
            <ci>a_m2</ci>
            <ci>a_m3</ci>
          </apply>
        </apply>
      </apply>
      <apply>
        <eq />
        <ci>s3</ci>
        <apply>
          <plus />
          <apply>
            <times />
            <ci>a_p1</ci>
            <ci>a_p2</ci>
          </apply>
          <apply>
            <times />
            <ci>a_m3</ci>
            <ci>a_m1</ci>
          </apply>
          <apply>
            <times />
            <ci>a_m3</ci>
            <ci>a_p2</ci>
          </apply>
        </apply>
      </apply>
      <apply>
        <eq />
        <ci>v_cycle</ci>
        <apply>
          <divide />
          <apply>
            <minus />
            <apply>
              <times />
              <ci>a_p1</ci>
              <ci>a_p2</ci>
              <ci>a_p3</ci>
            </apply>
            <apply>
              <times />
              <ci>a_m1</ci>
              <ci>a_m2</ci>
              <ci>a_m3</ci>
            </apply>
          </apply>
          <apply>
            <plus />
            <ci>s1</ci>
            <ci>s2</ci>
            <ci>s3</ci>
          </apply>
        </apply>
      </apply>
      <apply>
        <eq />
        <apply>
          <diff />
          <bvar>
            <ci>time</ci>
          </bvar>
          <ci>Ca_sr</ci>
        </apply>
        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="flux">1.0</cn>
      </apply>
    </math>
  </component>
  <connection>
    <map_components component_1="environment" component_2="SERCA" />
    <map_variables variable_1="time" variable_2="time" />
  </connection>
  <rdf:RDF xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:ro="http://www.obofoundry.org/ro/ro.owl#" xmlns:opb="http://bhi.washington.edu/OPB#" xmlns:j.0="http://imc.org/vCard/3.0#">
    <rdf:Description rdf:about="#environment_time">
      <semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_01023" />
      <dcterms:description>Simulation time domain</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="http://www.cellml.org/cellml/1.0" dc:publisher="">
      <dc:title>A Thermodynamic Model of the Cardiac Sarcoplasmic/Endoplasmic Ca(2+) (SERCA) Pump: the three-state SERCA model</dc:title>
      <cmeta:comment>
        <rdf:Description rdf:about="rdf:#59ac1836-2f1d-4123-9e4d-279bd99d90be">
          <dc:creator>
            <rdf:Description rdf:about="rdf:#f89919f3-1b06-4a91-b591-952b37d6146d">
              <vCard:FN>Catherine Lloyd</vCard:FN>
            </rdf:Description>
          </dc:creator>
          <rdf:value>This CellML model has been unit checked and is known to run in both PCEnv and COR.  This particular version of the CellML model describes the three-state cooperative SERCA model and recreates figure 13.  In order to recreate this figure we have had to add an additional equation to the model to define the rate of change in Casr.</rdf:value>
        </rdf:Description>
      </cmeta:comment>
      <dcterms:created rdf:resource="rdf:#f4cfda0d-7868-4c07-b67f-c405e97eee3e" dcterms:W3CDTF="2009-03-05T00:00:00+00:00" />
      <dc:creator>
        <rdf:Description rdf:about="rdf:#56464cca-dd1f-4ca3-adbb-ebdb90f265be">
          <vCard:ORG>
            <rdf:Description rdf:about="rdf:#05a40c92-02a0-4779-941b-2267d63e9f20">
              <vCard:Orgname>The University of Auckland</vCard:Orgname>
              <vCard:Orgunit>Auckland Bioengineering Institute</vCard:Orgunit>
            </rdf:Description>
          </vCard:ORG>
          <vCard:EMAIL rdf:resource="rdf:#b59fbe3f-3a81-46d3-a98c-90bb39108878" rdf:value="k.tran@auckland.ac.nz" rdf:type="http://imc.org/vCard/3.0#internet" />
          <vCard:N rdf:resource="rdf:#a3800ea1-7856-4edb-9cf1-0579364ed799" vCard:Given="Kenneth" vCard:Family="Tran" vCard:Other="" />
        </rdf:Description>
      </dc:creator>
    </rdf:Description>
    <rdf:Description rdf:about="#SERCA.time">
      <semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_01023" />
      <dcterms:description>Simulation time domain</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="#SERCA_ATP">
      <semsim:isComputationalComponentFor>
        <rdf:Description rdf:about="#property_2">
          <semsim:physicalPropertyOf>
            <rdf:Description rdf:about="#entity_4">
              <ro:part_of>
                <rdf:Description rdf:about="#entity_1">
                  <ro:part_of>
                    <rdf:Description rdf:about="#entity_2">
                      <semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/fma/FMA:14067" />
                    </rdf:Description>
                  </ro:part_of>
                  <semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/fma/FMA:66836" />
                </rdf:Description>
              </ro:part_of>
              <semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/chebi/CHEBI:15422" />
            </rdf:Description>
          </semsim:physicalPropertyOf>
          <semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_00340" />
        </rdf:Description>
      </semsim:isComputationalComponentFor>
      <dcterms:description>Concentration of adenosine triphosphate in the cytosol</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="#SERCA_Ca_sr">
      <semsim:isComputationalComponentFor>
        <rdf:Description rdf:about="#property_4">
          <semsim:physicalPropertyOf>
            <rdf:Description rdf:about="#entity_6">
              <ro:part_of>
                <rdf:Description rdf:about="#entity_7">
                  <ro:part_of>
                    <rdf:Description rdf:about="#entity_8">
                      <ro:part_of rdf:resource="#entity_2" />
                      <semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/fma/FMA:67225" />
                    </rdf:Description>
                  </ro:part_of>
                  <semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/fma/FMA:72444" />
                </rdf:Description>
              </ro:part_of>
              <semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/chebi/CHEBI:29108" />
            </rdf:Description>
          </semsim:physicalPropertyOf>
          <semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_00340" />
        </rdf:Description>
      </semsim:isComputationalComponentFor>
      <dcterms:description>Concentration of calcium in the sarcoplasmic reticulum</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="#SERCA_Ca_i">
      <semsim:isComputationalComponentFor>
        <rdf:Description rdf:about="#property_0">
          <semsim:physicalPropertyOf>
            <rdf:Description rdf:about="#entity_0">
              <ro:part_of rdf:resource="#entity_1" />
              <semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/chebi/CHEBI:29108" />
            </rdf:Description>
          </semsim:physicalPropertyOf>
          <semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_00340" />
        </rdf:Description>
      </semsim:isComputationalComponentFor>
      <dcterms:description>Concentration of calcium in the cytosol</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="http://www.cellml.org/cellml/1.0#tran_model_2009">
      <bqs:reference>
        <rdf:Description rdf:about="rdf:#dde09b5f-2570-44e4-b7af-2782b3f4dc03" bqs:Pubmed_id="19254563">
          <bqs:JournalArticle>
            <rdf:Description rdf:about="rdf:#1aa7136e-0363-4f6f-8e67-d823ba86d1ab" bqs:volume="96" bqs:first_page="2029" bqs:last_page="2042">
              <dc:creator>
                <rdf:Seq rdf:about="rdf:#277d3fce-1e82-45ea-884f-2e76a89f4a54">
                  <rdf:li>
                    <bqs:Person rdf:about="rdf:#5a8af88e-79ba-4e3a-a593-38f0298d25aa">
                      <vCard:N rdf:resource="rdf:#62cab138-9811-478d-9183-2d5af616ef1e" vCard:Given="Kenneth" vCard:Family="Tran" />
                    </bqs:Person>
                  </rdf:li>
                  <rdf:li>
                    <bqs:Person rdf:about="rdf:#3e2e26bb-0f27-47bd-bd91-6953b7b7b874">
                      <vCard:N rdf:resource="rdf:#01fe663c-eefc-4a1e-8d24-f6891a804dc2" vCard:Given="Nicolas" vCard:Family="Smith" vCard:Other="P" />
                    </bqs:Person>
                  </rdf:li>
                  <rdf:li>
                    <bqs:Person rdf:about="rdf:#7eff5bdd-8d4f-40df-8629-2acc3d9f4733">
                      <vCard:N rdf:resource="rdf:#6c88af07-dec5-4659-aa5c-908846a4c4ad" vCard:Given="Denis" vCard:Family="Loiselle" vCard:Other="S" />
                    </bqs:Person>
                  </rdf:li>
                  <rdf:li>
                    <bqs:Person rdf:about="rdf:#a2f05790-5ec5-42ca-a8d9-6db94a7a06eb">
                      <vCard:N rdf:resource="rdf:#b06c7bb6-6563-4d49-b6d0-be2036ec2c30" vCard:Given="Edmund" vCard:Family="Crampin" vCard:Other="J" />
                    </bqs:Person>
                  </rdf:li>
                </rdf:Seq>
              </dc:creator>
              <dc:title>A Thermodynamic Model of the Cardiac Sarcoplasmic/Endoplasmic Ca(2+) (SERCA) Pump</dc:title>
              <bqs:Journal>
                <rdf:Description rdf:about="rdf:#dbd53168-2407-4b79-a3da-77beb4f217ab">
                  <dc:title>Biophysical Journal</dc:title>
                </rdf:Description>
              </bqs:Journal>
              <dcterms:issued>
                <rdf:Description rdf:about="rdf:#80797212-992e-4436-9c29-95f80d6ea1d5">
                  <dcterms:W3CDTF>2009-03-00 00:00</dcterms:W3CDTF>
                </rdf:Description>
              </dcterms:issued>
            </rdf:Description>
          </bqs:JournalArticle>
        </rdf:Description>
      </bqs:reference>
      <bqs:reference rdf:parseType="Resource">
        <dc:subject rdf:parseType="Resource">
          <bqs:subject_type>keyword</bqs:subject_type>
          <rdf:value>
            <rdf:Bag>
              <rdf:li>electrophysiology</rdf:li>
              <rdf:li>cardiac</rdf:li>
              <rdf:li>SERCA</rdf:li>
              <rdf:li>calcium dynamics</rdf:li>
            </rdf:Bag>
          </rdf:value>
        </dc:subject>
      </bqs:reference>
      <cmeta:comment>
        <rdf:Description rdf:about="rdf:#594c54e4-2368-4aba-8dee-bd2175490d26" rdf:value="">
          <dc:creator rdf:resource="rdf:#6b548755-48ec-4433-8329-94c1c0c1c7c3" vCard:FN="" />
        </rdf:Description>
      </cmeta:comment>
    </rdf:Description>
    <rdf:Description rdf:about="#tran_smith_loiselle_crampin_2009" semsim:modelId="tran_model_2009" semsim:AnnotatorContactInfo="bcarl@umich.edu" semsim:modelName="tran_model_2009">
      <semsim:AnnotatorName>Brian Carlson</semsim:AnnotatorName>
      <semsim:ModelDescription>Model of the cardiac SERCA pump</semsim:ModelDescription>
    </rdf:Description>
    <rdf:Description rdf:about="#SERCA_P_i">
      <semsim:isComputationalComponentFor>
        <rdf:Description rdf:about="#property_3">
          <semsim:physicalPropertyOf>
            <rdf:Description rdf:about="#entity_5">
              <ro:part_of rdf:resource="#entity_1" />
              <semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/chebi/CHEBI:26020" />
            </rdf:Description>
          </semsim:physicalPropertyOf>
          <semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_00340" />
        </rdf:Description>
      </semsim:isComputationalComponentFor>
      <dcterms:description>Concentration of phosphate in the cytosol</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="#SERCA_ADP">
      <semsim:isComputationalComponentFor>
        <rdf:Description rdf:about="#property_5">
          <semsim:physicalPropertyOf>
            <rdf:Description rdf:about="#entity_9">
              <ro:part_of rdf:resource="#entity_1" />
              <semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/chebi/CHEBI:16761" />
            </rdf:Description>
          </semsim:physicalPropertyOf>
          <semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_00340" />
        </rdf:Description>
      </semsim:isComputationalComponentFor>
      <dcterms:description>Concentration of adenosine diphosphate in the cytosol</dcterms:description>
    </rdf:Description>
    <rdf:Description rdf:about="#SERCA_H_i">
      <semsim:isComputationalComponentFor>
        <rdf:Description rdf:about="#property_1">
          <semsim:physicalPropertyOf>
            <rdf:Description rdf:about="#entity_3" semsim:name="hydrogen(1+)">
              <ro:part_of rdf:resource="#entity_1" />
            </rdf:Description>
          </semsim:physicalPropertyOf>
          <semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_00340" />
        </rdf:Description>
      </semsim:isComputationalComponentFor>
      <dcterms:description>Concentration of hydrogen in the cytosol</dcterms:description>
    </rdf:Description>
  </rdf:RDF>
</model>