- Author:
- Dewan Sarwar <sarwarcse@gmail.com>
- Date:
- 2019-01-31 16:34:20+13:00
- Desc:
- Testing with Max's suggested way of annotation for weinstein_1995_max model
- Permanent Source URI:
- https://models.physiomeproject.org/workspace/584/rawfile/848b6a8fb585337adc4f3805c0ed682a6a5fd379/NaKATPase/Strieter_1992_NaK.cellml
<?xml version="1.0" encoding="UTF-8"?>
<model xmlns="http://www.cellml.org/cellml/1.1#" xmlns:cmeta="http://www.cellml.org/metadata/1.0#" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bqs="http://www.cellml.org/bqs/1.0#" xmlns:semsim="http://www.bhi.washington.edu/SemSim#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" name="Strieter_1992_NaK" cmeta:id="Strieter_1992_NaK">
<import xlink:href="Units/Units.cellml">
<units name="umol_per_s_per_cm2" units_ref="umol_per_s_per_cm2" />
</import>
<import xlink:href="Units/Units.cellml">
<units name="mM" units_ref="mM" />
</import>
<import xlink:href="Units/Units.cellml">
<units name="mV" units_ref="mV" />
</import>
<import xlink:href="Units/Units.cellml">
<units name="C_per_mol" units_ref="C_per_mol" />
</import>
<import xlink:href="Units/Units.cellml">
<units name="mJ_per_mol_per_kelvin" units_ref="mJ_per_mol_per_kelvin" />
</import>
<import xlink:href="Units/Units.cellml">
<units name="mA_per_cm2" units_ref="mA_per_cm2" />
</import>
<component name="NaK">
<variable cmeta:id="NaK.V" name="V" public_interface="in" units="mV" />
<variable cmeta:id="NaK.Na_int" name="Na_int" public_interface="in" units="mM" />
<variable cmeta:id="NaK.Na_ext" name="Na_ext" public_interface="in" units="mM" />
<variable cmeta:id="NaK.K_int" name="K_int" public_interface="in" units="mM" />
<variable cmeta:id="NaK.K_ext" name="K_ext" public_interface="in" units="mM" />
<variable cmeta:id="NaK.K_mNa" initial_value="13" name="K_mNa" units="mM" />
<variable cmeta:id="NaK.K_mK" initial_value="1" name="K_mK" units="mM" />
<variable cmeta:id="NaK.sigma" name="sigma" units="dimensionless" />
<variable cmeta:id="NaK.f_1" name="f_1" units="dimensionless" />
<variable cmeta:id="NaK.F" initial_value="96485" name="F" units="C_per_mol" />
<variable cmeta:id="NaK.R" initial_value="8314.41" name="R" units="mJ_per_mol_per_kelvin" />
<variable cmeta:id="NaK.T" initial_value="300" name="T" units="kelvin" />
<variable cmeta:id="NaK.J_NaK_max" name="J_NaK_max" public_interface="in" units="umol_per_s_per_cm2" />
<variable cmeta:id="NaK.J_NaK" name="J_NaK" public_interface="out" units="umol_per_s_per_cm2" />
<variable cmeta:id="NaK.I_NaK" name="I_NaK" public_interface="out" units="mA_per_cm2" />
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq />
<ci>sigma</ci>
<apply>
<times />
<apply>
<divide />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.1#" cellml:units="dimensionless">1</cn>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.1#" cellml:units="dimensionless">7</cn>
</apply>
<apply>
<minus />
<apply>
<exp />
<apply>
<divide />
<ci>Na_ext</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.1#" cellml:units="mM">67.3</cn>
</apply>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.1#" cellml:units="dimensionless">1</cn>
</apply>
</apply>
</apply>
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<apply>
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<apply>
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<minus />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.1#" cellml:units="dimensionless">0.1</cn>
</apply>
<ci>V</ci>
<ci>F</ci>
</apply>
<apply>
<times />
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<times />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.1#" cellml:units="dimensionless">0.04</cn>
<ci>sigma</ci>
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<exp />
<apply>
<divide />
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<times />
<apply>
<minus />
<ci>V</ci>
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<ci>F</ci>
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<apply>
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<ci>R</ci>
<ci>T</ci>
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<minus />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.1#" cellml:units="dimensionless">1</cn>
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</apply>
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<eq />
<ci>J_NaK</ci>
<apply>
<times />
<ci>J_NaK_max</ci>
<apply>
<power />
<apply>
<divide />
<ci>Na_int</ci>
<apply>
<plus />
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<ci>K_mNa</ci>
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<cn xmlns:cellml="http://www.cellml.org/cellml/1.1#" cellml:units="dimensionless">3</cn>
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<apply>
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<cn xmlns:cellml="http://www.cellml.org/cellml/1.1#" cellml:units="dimensionless">2</cn>
</apply>
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</apply>
<apply>
<eq />
<ci>I_NaK</ci>
<apply>
<times />
<ci>f_1</ci>
<ci>F</ci>
<ci>J_NaK</ci>
</apply>
</apply>
</math>
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<rdf:Description rdf:about="">
<dc:title>A kinetic model of Na+/K+-ATPase (sodium-potassium pump)</dc:title>
</rdf:Description>
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<semsim:isComputationalComponentFor>
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<semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>concentration of potassium in the mucosal compartment (luminal)</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#NaK.K_int">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_2">
<semsim:physicalPropertyOf>
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<ro:part_of rdf:resource="#entity_1" />
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</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>concentration of potassium in the cytosol compartment</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#Strieter_1992_NaK">
<bqs:reference rdf:parseType="Resource">
<dc:subject rdf:parseType="Resource">
<bqs:subject_type>keyword</bqs:subject_type>
<rdf:value>
<rdf:Bag>
<rdf:li>protein module</rdf:li>
</rdf:Bag>
</rdf:value>
</dc:subject>
</bqs:reference>
</rdf:Description>
<rdf:Description rdf:about="#NaK.Na_ext">
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<semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>concentration of sodium in the mucosal compartment (luminal)</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#Strieter_1992_NaK" semsim:modelId="Strieter_1992_NaK" semsim:modelName="Strieter_1992_NaK" />
</rdf:RDF>
</model>
