- Author:
- David Nickerson <nickerso@users.sourceforge.net>
- Date:
- 2018-04-19 18:07:33-07:00
- Desc:
- updating model and annotations and adding COMBINE archive manifest file
- Permanent Source URI:
- https://models.physiomeproject.org/workspace/4e3/rawfile/a7769367b201788d9ea33ddc1f6ffa8554611cb6/model/Kapela.cellml
<?xml version="1.0" encoding="UTF-8"?>
<model xmlns="http://www.cellml.org/cellml/1.1#" xmlns:cmeta="http://www.cellml.org/metadata/1.0#" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bqs="http://www.cellml.org/bqs/1.0#" xmlns:semsim="http://www.bhi.washington.edu/SemSim#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" name="Kapela_VSM_Final">
<units name="picoliter">
<unit exponent="3.0" multiplier="1.0E-15" units="metre" />
</units>
<units name="per__ms_x_mM2_">
<unit exponent="-2.0" units="mole" />
<unit exponent="-1.0" units="second" />
<unit exponent="6.0" multiplier="1000.0" units="metre" />
</units>
<units name="mM">
<unit units="mole" />
<unit exponent="-3.0" units="metre" />
</units>
<units name="per_ms">
<unit exponent="-1.0" multiplier="1000.0" units="second" />
</units>
<units name="nanosiemens">
<unit exponent="3.0" units="second" />
<unit exponent="-1.0" multiplier="1.0E-9" units="kilogram" />
<unit exponent="-2.0" units="metre" />
<unit exponent="2.0" units="ampere" />
</units>
<units name="coulomb_x_mV_per__K_x_mol_">
<unit exponent="-1.0" units="mole" />
<unit multiplier="0.001" units="kilogram" />
<unit exponent="2.0" units="metre" />
<unit exponent="-2.0" units="second" />
<unit exponent="-1.0" units="kelvin" />
</units>
<units name="mV_per_msec">
<unit exponent="-1.0" units="ampere" />
<unit units="kilogram" />
<unit exponent="2.0" units="metre" />
<unit exponent="-4.0" units="second" />
</units>
<units name="per_cm2">
<unit exponent="-2.0" multiplier="10000.0" units="metre" />
</units>
<units name="per_msec">
<unit exponent="-1.0" multiplier="1000.0" units="second" />
</units>
<units name="per_mV">
<unit units="ampere" />
<unit exponent="3.0" units="second" />
<unit exponent="-2.0" units="metre" />
<unit exponent="-1.0" multiplier="1000.0" units="kilogram" />
</units>
<units name="mV">
<unit exponent="2.0" units="metre" />
<unit multiplier="0.001" units="kilogram" />
<unit exponent="-3.0" units="second" />
<unit exponent="-1.0" units="ampere" />
</units>
<units name="mol2_per__J_x_s_x_cm2_">
<unit units="second" />
<unit exponent="2.0" units="mole" />
<unit exponent="-1.0" multiplier="10000.0" units="kilogram" />
<unit exponent="-4.0" units="metre" />
</units>
<units name="ms">
<unit multiplier="0.001" units="second" />
</units>
<units name="mM_per_msec">
<unit exponent="-1.0" units="second" />
<unit exponent="-3.0" multiplier="1000.0" units="metre" />
<unit units="mole" />
</units>
<units name="coulomb_x_mV_per_mol">
<unit exponent="-2.0" units="second" />
<unit exponent="-1.0" units="mole" />
<unit multiplier="0.001" units="kilogram" />
<unit exponent="2.0" units="metre" />
</units>
<units name="picoampere">
<unit multiplier="1.0E-12" units="ampere" />
</units>
<units name="msec">
<unit multiplier="0.001" units="second" />
</units>
<units name="nanosiemens_per_picofarad">
<unit exponent="-1.0" multiplier="1000.0" units="second" />
</units>
<units name="cm_per_s">
<unit multiplier="0.01" units="metre" />
<unit exponent="-1.0" units="second" />
</units>
<units name="picofarad">
<unit exponent="4.0" units="second" />
<unit exponent="2.0" units="ampere" />
<unit exponent="-1.0" multiplier="1.0E-12" units="kilogram" />
<unit exponent="-2.0" units="metre" />
</units>
<units name="mM_per_ms_per_msec">
<unit exponent="-2.0" units="second" />
<unit units="mole" />
<unit exponent="-3.0" multiplier="1000000.0" units="metre" />
</units>
<units name="per__ms_x_mM_">
<unit exponent="-1.0" units="second" />
<unit exponent="-1.0" units="mole" />
<unit exponent="3.0" multiplier="1000.0" units="metre" />
</units>
<units name="mM2">
<unit exponent="-6.0" units="metre" />
<unit exponent="2.0" units="mole" />
</units>
<units name="per_ms_x_1_per_mol_x_picoliter_x_mM">
<unit exponent="-1.0" multiplier="1.0E-12" units="second" />
</units>
<units name="cm3_per_s">
<unit exponent="-1.0" units="second" />
<unit exponent="3.0" multiplier="1.0E-6" units="metre" />
</units>
<units name="K">
<unit units="kelvin" />
</units>
<units name="per_mol">
<unit exponent="-1.0" units="mole" />
</units>
<units name="picoampere_per_picofarad">
<unit exponent="-4.0" units="second" />
<unit exponent="2.0" units="metre" />
<unit units="kilogram" />
<unit exponent="-1.0" units="ampere" />
</units>
<units name="picofarad_per_cm2">
<unit exponent="4.0" units="second" />
<unit exponent="-1.0" multiplier="1.0E-8" units="kilogram" />
<unit exponent="2.0" units="ampere" />
<unit exponent="-4.0" units="metre" />
</units>
<units name="cm2">
<unit exponent="2.0" multiplier="1.0E-4" units="metre" />
</units>
<units name="per_mol_x_picoliter">
<unit exponent="-1.0" units="mole" />
<unit exponent="3.0" multiplier="1.0E-15" units="metre" />
</units>
<units name="mM_per_ms">
<unit units="mole" />
<unit exponent="-3.0" multiplier="1000.0" units="metre" />
<unit exponent="-1.0" units="second" />
</units>
<units name="uM">
<unit units="mole" />
<unit exponent="-3.0" multiplier="0.001" units="metre" />
</units>
<units name="coulomb_per_mol">
<unit units="second" />
<unit exponent="-1.0" units="mole" />
<unit units="ampere" />
</units>
<component name="environment">
<variable cmeta:id="env_time" name="time" public_interface="out" units="msec" />
</component>
<component name="Kapela">
<variable cmeta:id="ICa_SOC" name="ICa_SOC" units="picoampere" />
<variable cmeta:id="K_CSQN" initial_value="0.8" name="K_CSQN" units="mM" />
<variable cmeta:id="E_Na" name="E_Na" units="mV" />
<variable cmeta:id="P_SOC0" initial_value="0.0" name="P_SOC0" units="dimensionless" />
<variable cmeta:id="p_f" initial_value="p_f0" name="p_f" units="dimensionless" />
<variable cmeta:id="d_NCX" initial_value="3.0E-4" name="d_NCX" units="dimensionless" />
<variable cmeta:id="d_L0" name="d_L0" units="dimensionless" />
<variable cmeta:id="q_10" name="q_10" units="dimensionless" />
<variable cmeta:id="Na_i0" initial_value="8.4" name="Na_i0" units="mM" />
<variable cmeta:id="G_TG" initial_value="100000.0" name="G_TG" units="dimensionless" />
<variable cmeta:id="G_0" name="G_0" units="dimensionless" />
<variable cmeta:id="I_SERCA" name="I_SERCA" units="picoampere" />
<variable cmeta:id="k_DsGC" initial_value="4.0E-4" name="k_DsGC" units="per_ms" />
<variable cmeta:id="V_50KCa0" name="V_50KCa0" units="mV" />
<variable cmeta:id="PIP2_0" name="PIP2_0" units="dimensionless" />
<variable cmeta:id="I_stim" name="I_stim" units="picoampere" />
<variable cmeta:id="INa_NSC" name="INa_NSC" units="picoampere" />
<variable cmeta:id="I_Kv" name="I_Kv" units="picoampere" />
<variable cmeta:id="K_ClcGMP" initial_value="0.0064" name="K_ClcGMP" units="mM" />
<variable cmeta:id="tau_fL" name="tau_fL" units="ms" />
<variable cmeta:id="NO_base" initial_value="1.0E-12" name="NO_base" units="mM" />
<variable cmeta:id="k_pdecGMP" initial_value="6.95E-5" name="k_pdecGMP" units="per_ms" />
<variable cmeta:id="p_K" initial_value="p_K0" name="p_K" units="dimensionless" />
<variable cmeta:id="Q_10" initial_value="1.87" name="Q_10" units="dimensionless" />
<variable cmeta:id="A1_sGC" name="A1_sGC" units="mM" />
<variable cmeta:id="i_KCa" name="i_KCa" units="picoampere" />
<variable cmeta:id="k_DrsGC" initial_value="1.0E-4" name="k_DrsGC" units="per_ms" />
<variable cmeta:id="tau_SOC" initial_value="100.0" name="tau_SOC" units="ms" />
<variable cmeta:id="Ca_i0" initial_value="6.8E-5" name="Ca_i0" units="mM" />
<variable cmeta:id="Ca_u" initial_value="Ca_u0" name="Ca_u" units="mM" />
<variable cmeta:id="RT" name="RT" units="coulomb_x_mV_per_mol" />
<variable cmeta:id="Ca_r" initial_value="Ca_r0" name="Ca_r" units="mM" />
<variable cmeta:id="k_2sGC" initial_value="6.4E-6" name="k_2sGC" units="per_ms" />
<variable cmeta:id="PCa_NSC" name="PCa_NSC" units="cm_per_s" />
<variable cmeta:id="Istim_amp" initial_value="0.0" name="Istim_amp" units="picoampere" />
<variable cmeta:id="dV_50KCaNO" initial_value="46.3" name="dV_50KCaNO" units="mV" />
<variable cmeta:id="ICl_NaKCl" name="ICl_NaKCl" units="picoampere" />
<variable cmeta:id="Ca_u0" initial_value="0.66" name="Ca_u0" units="mM" />
<variable cmeta:id="P_KCa" name="P_KCa" units="dimensionless" />
<variable cmeta:id="tau_ps" initial_value="35.9" name="tau_ps" units="ms" />
<variable cmeta:id="Ca_i" initial_value="Ca_i0" name="Ca_i" units="mM" />
<variable cmeta:id="V_50KCa" name="V_50KCa" units="mV" />
<variable cmeta:id="R_leak" initial_value="1.07E-5" name="R_leak" units="dimensionless" />
<variable cmeta:id="I_SOC" name="I_SOC" units="picoampere" />
<variable cmeta:id="g_NCX" initial_value="4.87E-4" name="g_NCX" units="picoampere" />
<variable cmeta:id="f_L" initial_value="f_L0" name="f_L" units="dimensionless" />
<variable cmeta:id="Ca_e" initial_value="2.0" name="Ca_e" units="mM" />
<variable cmeta:id="K_mup" initial_value="0.0010" name="K_mup" units="mM" />
<variable cmeta:id="R_cGMP" name="R_cGMP" units="dimensionless" />
<variable cmeta:id="K_dKe" initial_value="1.6" name="K_dKe" units="mM" />
<variable cmeta:id="d_L" initial_value="d_L0" name="d_L" units="dimensionless" />
<variable cmeta:id="P_SOC" initial_value="0.0" name="P_SOC" units="dimensionless" />
<variable cmeta:id="tau_pf" initial_value="0.84" name="tau_pf" units="ms" />
<variable cmeta:id="Vol_Ca" initial_value="0.7" name="Vol_Ca" units="picoliter" />
<variable cmeta:id="gNa_SOC" initial_value="0.0575" name="gNa_SOC" units="nanosiemens" />
<variable cmeta:id="dbar_L" name="dbar_L" units="dimensionless" />
<variable cmeta:id="V_cGMP" initial_value="V_cGMP0" name="V_cGMP" units="mM_per_ms" />
<variable cmeta:id="IP3" initial_value="IP3_0" name="IP3" units="mM" />
<variable cmeta:id="Ibar_PMCA" initial_value="5.37" name="Ibar_PMCA" units="picoampere" />
<variable cmeta:id="I_IP3" name="I_IP3" units="picoampere" />
<variable cmeta:id="ICa_NSC" name="ICa_NSC" units="picoampere" />
<variable cmeta:id="pbar_o" name="pbar_o" units="dimensionless" />
<variable cmeta:id="K_inhIP3" initial_value="1.0E-4" name="K_inhIP3" units="mM" />
<variable cmeta:id="B5_sGC" name="B5_sGC" units="mM" />
<variable cmeta:id="R_NO0" name="R_NO0" units="dimensionless" />
<variable cmeta:id="tau_dL" name="tau_dL" units="ms" />
<variable cmeta:id="V_m" initial_value="V_m0" name="V_m" units="mV" />
<variable cmeta:id="V_cGMP0" initial_value="0.0" name="V_cGMP0" units="mM_per_ms" />
<variable cmeta:id="I_NaK" name="I_NaK" units="picoampere" />
<variable cmeta:id="gamma_NCX" initial_value="0.45" name="gamma_NCX" units="dimensionless" />
<variable cmeta:id="P_BKCa" initial_value="3.9E-13" name="P_BKCa" units="cm3_per_s" />
<variable cmeta:id="tau_q2" initial_value="2884.0" name="tau_q2" units="ms" />
<variable cmeta:id="tau_q1" initial_value="371.0" name="tau_q1" units="ms" />
<variable cmeta:id="K_i0" initial_value="140.0" name="K_i0" units="mM" />
<variable cmeta:id="alpha_Cl" name="alpha_Cl" units="dimensionless" />
<variable cmeta:id="P_Cl" name="P_Cl" units="dimensionless" />
<variable cmeta:id="tau_pK" name="tau_pK" units="ms" />
<variable cmeta:id="Po_NSC" name="Po_NSC" units="dimensionless" />
<variable cmeta:id="R_cGMP0" name="R_cGMP0" units="dimensionless" />
<variable cmeta:id="Na_dNai" initial_value="22.0" name="Na_dNai" units="mM" />
<variable cmeta:id="R_supSG0" name="R_supSG0" units="dimensionless" />
<variable cmeta:id="R_11" initial_value="R_110" name="R_11" units="dimensionless" />
<variable cmeta:id="R_10" initial_value="R_100" name="R_10" units="dimensionless" />
<variable cmeta:id="V_m0" initial_value="-59.4" name="V_m0" units="mV" />
<variable cmeta:id="pbar_K" name="pbar_K" units="dimensionless" />
<variable cmeta:id="n_HNai" initial_value="1.7" name="n_HNai" units="dimensionless" />
<variable cmeta:id="rho_rG" name="rho_rG" units="dimensionless" />
<variable cmeta:id="gamma_G" name="gamma_G" units="per_mol_x_picoliter" />
<variable cmeta:id="alpha_G" initial_value="2.781E-8" name="alpha_G" units="per_ms" />
<variable cmeta:id="k_3sGC" initial_value="4.2" name="k_3sGC" units="per__ms_x_mM_" />
<variable cmeta:id="z_Cl" initial_value="-1.0" name="z_Cl" units="dimensionless" />
<variable cmeta:id="gCa_SOC" initial_value="0.0083" name="gCa_SOC" units="nanosiemens" />
<variable cmeta:id="K_ClCa" initial_value="3.65E-4" name="K_ClCa" units="mM" />
<variable cmeta:id="R_NaKClcGMP" name="R_NaKClcGMP" units="dimensionless" />
<variable cmeta:id="A0_sGC" name="A0_sGC" units="mM2" />
<variable cmeta:id="Ibar_IP3" initial_value="0.00288" name="Ibar_IP3" units="per_ms" />
<variable cmeta:id="R_01" initial_value="R_010" name="R_01" units="dimensionless" />
<variable cmeta:id="INa_totm" name="INa_totm" units="picoampere" />
<variable cmeta:id="R_00" name="R_00" units="dimensionless" />
<variable cmeta:id="z_Ca" initial_value="2.0" name="z_Ca" units="dimensionless" />
<variable cmeta:id="I_NSC" name="I_NSC" units="picoampere" />
<variable cmeta:id="Ibar_NaK" initial_value="2.3083" name="Ibar_NaK" units="picoampere_per_picofarad" />
<variable cmeta:id="Ca_r0" initial_value="0.57" name="Ca_r0" units="mM" />
<variable cmeta:id="k_rG" initial_value="1.75E-7" name="k_rG" units="per_ms" />
<variable cmeta:id="n_ClCa" initial_value="2.0" name="n_ClCa" units="dimensionless" />
<variable cmeta:id="R_TG" initial_value="20000.0" name="R_TG" units="dimensionless" />
<variable cmeta:id="R_110" initial_value="4.0E-6" name="R_110" units="dimensionless" />
<variable cmeta:id="PK_NSC" name="PK_NSC" units="cm_per_s" />
<variable cmeta:id="ICl_totm" name="ICl_totm" units="picoampere" />
<variable cmeta:id="I_BKCa" name="I_BKCa" units="picoampere" />
<variable cmeta:id="qbar" name="qbar" units="dimensionless" />
<variable cmeta:id="f_L0" name="f_L0" units="dimensionless" />
<variable cmeta:id="k_eG" initial_value="6.0E-6" name="k_eG" units="per_ms" />
<variable cmeta:id="tau_rel" initial_value="0.0333" name="tau_rel" units="ms" />
<variable cmeta:id="p_s0" name="p_s0" units="dimensionless" />
<variable cmeta:id="cGMP_i" initial_value="cGMP_i0" name="cGMP_i" units="mM" />
<variable cmeta:id="NO" name="NO" units="mM" />
<variable cmeta:id="k_m1sGC" initial_value="0.015" name="k_m1sGC" units="per_ms" />
<variable cmeta:id="h_IP3" initial_value="h_IP30" name="h_IP3" units="dimensionless" />
<variable cmeta:id="tau_sGC" name="tau_sGC" units="ms" />
<variable cmeta:id="Pbar_SOC" name="Pbar_SOC" units="dimensionless" />
<variable cmeta:id="I_rel" name="I_rel" units="picoampere" />
<variable cmeta:id="FRT" name="FRT" units="per_mV" />
<variable cmeta:id="z_Na" initial_value="1.0" name="z_Na" units="dimensionless" />
<variable cmeta:id="R_100" initial_value="0.0033" name="R_100" units="dimensionless" />
<variable cmeta:id="NE" name="NE" units="mM" />
<variable cmeta:id="R_supSPG" initial_value="R_supSPG0" name="R_supSPG" units="dimensionless" />
<variable cmeta:id="k_degG" initial_value="0.00125" name="k_degG" units="per_ms" />
<variable cmeta:id="Ibar_SERCA" initial_value="6.68" name="Ibar_SERCA" units="picoampere" />
<variable cmeta:id="Cl_i0" initial_value="59.4" name="Cl_i0" units="mM" />
<variable cmeta:id="p_f0" name="p_f0" units="dimensionless" />
<variable cmeta:id="K_r2" initial_value="1.05" name="K_r2" units="per__ms_x_mM_" />
<variable cmeta:id="K_r1" initial_value="2500.0" name="K_r1" units="per__ms_x_mM2_" />
<variable cmeta:id="Bbar_F" initial_value="0.1" name="Bbar_F" units="mM" />
<variable cmeta:id="I_PMCA" name="I_PMCA" units="picoampere" />
<variable cmeta:id="R_ClcGMPmin" initial_value="0.0132" name="R_ClcGMPmin" units="dimensionless" />
<variable cmeta:id="I_Kleak" name="I_Kleak" units="picoampere" />
<variable cmeta:id="k_dG" initial_value="0.0015" name="k_dG" units="per_ms" />
<variable cmeta:id="Na_i" initial_value="Na_i0" name="Na_i" units="mM" />
<variable cmeta:id="Vol_SRu" initial_value="0.07" name="Vol_SRu" units="picoliter" />
<variable cmeta:id="PIP2" initial_value="PIP2_0" name="PIP2" units="dimensionless" />
<variable cmeta:id="Na_e" initial_value="140.0" name="Na_e" units="mM" />
<variable cmeta:id="Vol_SRr" initial_value="0.0070" name="Vol_SRr" units="picoliter" />
<variable cmeta:id="Cl_i" initial_value="Cl_i0" name="Cl_i" units="mM" />
<variable cmeta:id="k_pG" initial_value="1.0E-4" name="k_pG" units="per_ms" />
<variable cmeta:id="g_Kv" initial_value="1.35" name="g_Kv" units="nanosiemens" />
<variable cmeta:id="n_HKe" initial_value="1.1" name="n_HKe" units="dimensionless" />
<variable cmeta:id="Cl_e" initial_value="129.0" name="Cl_e" units="mM" />
<variable cmeta:id="K_mPMCA" initial_value="1.7E-4" name="K_mPMCA" units="mM" />
<variable cmeta:id="K_mr2" initial_value="0.084" name="K_mr2" units="per_ms" />
<variable cmeta:id="K_mr1" initial_value="0.0076" name="K_mr1" units="per_ms" />
<variable cmeta:id="dV_50KCacGMP" initial_value="76.0" name="dV_50KCacGMP" units="mV" />
<variable cmeta:id="ICa_totm" name="ICa_totm" units="picoampere" />
<variable cmeta:id="phi_R" name="phi_R" units="dimensionless" />
<variable cmeta:id="time" name="time" public_interface="in" units="msec" />
<variable cmeta:id="g_ClCa" initial_value="0.23" name="g_ClCa" units="nanosiemens_per_picofarad" />
<variable cmeta:id="K_SOC" initial_value="1.0E-4" name="K_SOC" units="mM" />
<variable cmeta:id="R_supSG" initial_value="R_supSG0" name="R_supSG" units="dimensionless" />
<variable cmeta:id="IK_NSC" name="IK_NSC" units="picoampere" />
<variable cmeta:id="r_hG0" name="r_hG0" units="per_ms_x_1_per_mol_x_picoliter_x_mM" />
<variable cmeta:id="K_dB" initial_value="5.298E-4" name="K_dB" units="mM" />
<variable cmeta:id="P_VOCC" initial_value="1.88E-5" name="P_VOCC" units="cm_per_s" />
<variable cmeta:id="R_supSPG0" initial_value="0.0" name="R_supSPG0" units="dimensionless" />
<variable cmeta:id="phi_F" name="phi_F" units="dimensionless" />
<variable cmeta:id="I_NCX" name="I_NCX" units="picoampere" />
<variable cmeta:id="n_ClcGMP" initial_value="3.3" name="n_ClcGMP" units="dimensionless" />
<variable cmeta:id="V_cGMPmax" initial_value="1.26E-7" name="V_cGMPmax" units="mM_per_ms" />
<variable cmeta:id="q_2" initial_value="q_20" name="q_2" units="dimensionless" />
<variable cmeta:id="q_1" initial_value="q_10" name="q_1" units="dimensionless" />
<variable cmeta:id="K_2G" initial_value="0.2" name="K_2G" units="mM" />
<variable cmeta:id="N_Avo" initial_value="6.022E23" name="N_Avo" units="per_mol" />
<variable cmeta:id="INa_NaKCl" name="INa_NaKCl" units="picoampere" />
<variable cmeta:id="K_IP3" initial_value="1.2E-4" name="K_IP3" units="mM" />
<variable cmeta:id="xi_G" initial_value="0.85" name="xi_G" units="dimensionless" />
<variable cmeta:id="K_cG" initial_value="4.0E-4" name="K_cG" units="mM" />
<variable cmeta:id="k_m2sGC" initial_value="1.0E-7" name="k_m2sGC" units="per_ms" />
<variable cmeta:id="NE_amp" initial_value="0.0010" name="NE_amp" units="mM" />
<variable cmeta:id="p_K0" name="p_K0" units="dimensionless" />
<variable cmeta:id="N_BKCa" initial_value="6600000.0" name="N_BKCa" units="per_cm2" />
<variable cmeta:id="r_hG" name="r_hG" units="per_ms" />
<variable cmeta:id="K_1G" initial_value="0.01" name="K_1G" units="mM" />
<variable cmeta:id="fbar_L" name="fbar_L" units="dimensionless" />
<variable cmeta:id="cGMP_i0" initial_value="0.0" name="cGMP_i0" units="mM" />
<variable cmeta:id="K_mpde" initial_value="0.0010" name="K_mpde" units="mM" />
<variable cmeta:id="Sbar_CM" initial_value="0.1" name="Sbar_CM" units="mM" />
<variable cmeta:id="I_tr" name="I_tr" units="picoampere" />
<variable cmeta:id="T" initial_value="293.0" name="T" units="K" />
<variable cmeta:id="k_aG" initial_value="1.7E-4" name="k_aG" units="per_ms" />
<variable cmeta:id="R" initial_value="8314.472" name="R" units="coulomb_x_mV_per__K_x_mol_" />
<variable cmeta:id="Vbar_cGMP" name="Vbar_cGMP" units="mM_per_ms" />
<variable cmeta:id="Q" name="Q" units="dimensionless" />
<variable cmeta:id="I_VOCC" name="I_VOCC" units="picoampere" />
<variable cmeta:id="G" initial_value="G_0" name="G" units="dimensionless" />
<variable cmeta:id="F" initial_value="96485.3399" name="F" units="coulomb_per_mol" />
<variable cmeta:id="IK_totm" name="IK_totm" units="picoampere" />
<variable cmeta:id="K_NSC" initial_value="0.0030" name="K_NSC" units="mM" />
<variable cmeta:id="k_onIP3" initial_value="1.4" name="k_onIP3" units="per__ms_x_mM_" />
<variable cmeta:id="h_IP30" name="h_IP30" units="dimensionless" />
<variable cmeta:id="R_NCXcGMP" name="R_NCXcGMP" units="dimensionless" />
<variable cmeta:id="tau_tr" initial_value="1000.0" name="tau_tr" units="ms" />
<variable cmeta:id="I_ClCa" name="I_ClCa" units="picoampere" />
<variable cmeta:id="INa_SOC" name="INa_SOC" units="picoampere" />
<variable cmeta:id="K_i" initial_value="K_i0" name="K_i" units="mM" />
<variable cmeta:id="Vol_i" initial_value="1.0" name="Vol_i" units="picoliter" />
<variable cmeta:id="K_e" initial_value="5.0" name="K_e" units="mM" />
<variable cmeta:id="K_actIP3" initial_value="1.7E-4" name="K_actIP3" units="mM" />
<variable cmeta:id="NO_0" initial_value="1.0E-12" name="NO_0" units="mM" />
<variable cmeta:id="K_ClCacGMP" name="K_ClCacGMP" units="mM" />
<variable cmeta:id="E_Cl" name="E_Cl" units="mV" />
<variable cmeta:id="R_NO" name="R_NO" units="dimensionless" />
<variable cmeta:id="d_NSCmin" initial_value="0.0244" name="d_NSCmin" units="dimensionless" />
<variable cmeta:id="IK_NaKCl" name="IK_NaKCl" units="picoampere" />
<variable cmeta:id="g_Kleak" initial_value="0.067" name="g_Kleak" units="nanosiemens" />
<variable cmeta:id="K_dCM" initial_value="2.6E-4" name="K_dCM" units="mM" />
<variable cmeta:id="PNa_NSC" initial_value="5.11E-7" name="PNa_NSC" units="cm_per_s" />
<variable cmeta:id="E_Ca" name="E_Ca" units="mV" />
<variable cmeta:id="C_m" initial_value="25.0" name="C_m" units="picofarad" />
<variable cmeta:id="r_rG" initial_value="1.5E-5" name="r_rG" units="per_ms" />
<variable cmeta:id="OPtot_IP3" name="OPtot_IP3" units="dimensionless" />
<variable cmeta:id="L_NaKCl" initial_value="1.79E-17" name="L_NaKCl" units="mol2_per__J_x_s_x_cm2_" />
<variable cmeta:id="k_1sGC" initial_value="2000.0" name="k_1sGC" units="per__ms_x_mM_" />
<variable cmeta:id="DAG" name="DAG" units="mM" />
<variable cmeta:id="A_m" name="A_m" units="cm2" />
<variable cmeta:id="R_010" initial_value="0.9955" name="R_010" units="dimensionless" />
<variable cmeta:id="CSQNbar" initial_value="15.0" name="CSQNbar" units="mM" />
<variable cmeta:id="q_20" name="q_20" units="dimensionless" />
<variable cmeta:id="IP3_0" initial_value="0.0" name="IP3_0" units="mM" />
<variable cmeta:id="deltaG_0" name="deltaG_0" units="dimensionless" />
<variable cmeta:id="PIP2_T" initial_value="5.0E7" name="PIP2_T" units="dimensionless" />
<variable cmeta:id="E_K" name="E_K" units="mV" />
<variable cmeta:id="p_s" initial_value="p_s0" name="p_s" units="dimensionless" />
<variable cmeta:id="z_K" initial_value="1.0" name="z_K" units="dimensionless" />
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq />
<ci>gamma_G</ci>
<apply>
<times />
<ci>N_Avo</ci>
<ci>Vol_i</ci>
</apply>
</apply>
</math>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq />
<ci>RT</ci>
<apply>
<times />
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</math>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq />
<ci>FRT</ci>
<apply>
<divide />
<ci>F</ci>
<ci>RT</ci>
</apply>
</apply>
</math>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq />
<ci>A_m</ci>
<apply>
<divide />
<ci>C_m</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="picofarad_per_cm2">1E6</cn>
</apply>
</apply>
</math>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq />
<ci>PK_NSC</ci>
<apply>
<times />
<ci>PNa_NSC</ci>
<cn>1.06</cn>
</apply>
</apply>
</math>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq />
<ci>PCa_NSC</ci>
<apply>
<times />
<ci>PNa_NSC</ci>
<cn>4.54</cn>
</apply>
</apply>
</math>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq />
<ci>Q</ci>
<apply>
<power />
<ci>Q_10</ci>
<apply>
<divide />
<apply>
<minus />
<ci>T</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="K">309.15</cn>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="K">10</cn>
</apply>
</apply>
</apply>
</math>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq />
<ci>B5_sGC</ci>
<apply>
<divide />
<ci>k_2sGC</ci>
<ci>k_3sGC</ci>
</apply>
</apply>
</math>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq />
<ci>A0_sGC</ci>
<apply>
<divide />
<apply>
<plus />
<apply>
<times />
<apply>
<plus />
<ci>k_m1sGC</ci>
<ci>k_2sGC</ci>
</apply>
<ci>k_DsGC</ci>
</apply>
<apply>
<times />
<ci>k_m1sGC</ci>
<ci>k_m2sGC</ci>
</apply>
</apply>
<apply>
<times />
<ci>k_1sGC</ci>
<ci>k_3sGC</ci>
</apply>
</apply>
</apply>
</math>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq />
<ci>A1_sGC</ci>
<apply>
<divide />
<apply>
<plus />
<apply>
<times />
<apply>
<plus />
<ci>k_1sGC</ci>
<ci>k_3sGC</ci>
</apply>
<ci>k_DsGC</ci>
</apply>
<apply>
<times />
<apply>
<plus />
<ci>k_2sGC</ci>
<ci>k_m2sGC</ci>
</apply>
<ci>k_1sGC</ci>
</apply>
</apply>
<apply>
<times />
<ci>k_1sGC</ci>
<ci>k_3sGC</ci>
</apply>
</apply>
</apply>
</math>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq />
<apply>
<diff />
<bvar>
<ci>time</ci>
</bvar>
<ci>R_supSG</ci>
</apply>
<apply>
<minus />
<apply>
<minus />
<apply>
<times />
<apply>
<times />
<ci>k_rG</ci>
<ci>xi_G</ci>
</apply>
<ci>R_TG</ci>
</apply>
<apply>
<times />
<apply>
<plus />
<ci>k_rG</ci>
<apply>
<divide />
<apply>
<times />
<ci>k_pG</ci>
<ci>NE</ci>
</apply>
<apply>
<plus />
<ci>K_1G</ci>
<ci>NE</ci>
</apply>
</apply>
</apply>
<ci>R_supSG</ci>
</apply>
</apply>
<apply>
<times />
<ci>k_rG</ci>
<ci>R_supSPG</ci>
</apply>
</apply>
</apply>
</math>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq />
<apply>
<diff />
<bvar>
<ci>time</ci>
</bvar>
<ci>V_m</ci>
</apply>
<apply>
<times />
<apply>
<divide />
<cn>1</cn>
<ci>C_m</ci>
</apply>
<apply>
<plus />
<apply>
<times />
<apply>
<plus />
<apply>
<plus />
<apply>
<plus />
<apply>
<plus />
<apply>
<plus />
<apply>
<plus />
<apply>
<plus />
<apply>
<plus />
<apply>
<plus />
<ci>I_VOCC</ci>
<ci>I_BKCa</ci>
</apply>
<ci>I_Kv</ci>
</apply>
<ci>I_Kleak</ci>
</apply>
<ci>I_NSC</ci>
</apply>
<ci>I_SOC</ci>
</apply>
<ci>I_ClCa</ci>
</apply>
<ci>I_PMCA</ci>
</apply>
<ci>I_NCX</ci>
</apply>
<ci>I_NaK</ci>
</apply>
<cn>-1</cn>
</apply>
<ci>I_stim</ci>
</apply>
</apply>
</apply>
</math>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq />
<apply>
<diff />
<bvar>
<ci>time</ci>
</bvar>
<ci>R_supSPG</ci>
</apply>
<apply>
<times />
<ci>NE</ci>
<apply>
<minus />
<apply>
<divide />
<apply>
<times />
<ci>k_pG</ci>
<ci>R_supSG</ci>
</apply>
<apply>
<plus />
<ci>K_1G</ci>
<ci>NE</ci>
</apply>
</apply>
<apply>
<divide />
<apply>
<times />
<ci>k_eG</ci>
<ci>R_supSPG</ci>
</apply>
<apply>
<plus />
<ci>K_2G</ci>
<ci>NE</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</math>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq />
<apply>
<diff />
<bvar>
<ci>time</ci>
</bvar>
<ci>IP3</ci>
</apply>
<apply>
<times />
<apply>
<minus />
<apply>
<divide />
<apply>
<times />
<ci>r_hG</ci>
<ci>PIP2</ci>
</apply>
<ci>gamma_G</ci>
</apply>
<apply>
<times />
<apply>
<times />
<ci>k_degG</ci>
<ci>IP3</ci>
</apply>
<cn>1E-15</cn>
</apply>
</apply>
<cn>1E15</cn>
</apply>
</apply>
</math>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq />
<apply>
<diff />
<bvar>
<ci>time</ci>
</bvar>
<ci>PIP2</ci>
</apply>
<apply>
<plus />
<apply>
<minus />
<apply>
<times />
<apply>
<times />
<apply>
<plus />
<ci>r_hG</ci>
<ci>r_rG</ci>
</apply>
<ci>PIP2</ci>
</apply>
<cn>-1</cn>
</apply>
<apply>
<times />
<apply>
<times />
<apply>
<times />
<ci>r_rG</ci>
<ci>gamma_G</ci>
</apply>
<ci>IP3</ci>
</apply>
<cn>1E-15</cn>
</apply>
</apply>
<apply>
<times />
<ci>r_rG</ci>
<ci>PIP2_T</ci>
</apply>
</apply>
</apply>
</math>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq />
<apply>
<diff />
<bvar>
<ci>time</ci>
</bvar>
<ci>G</ci>
</apply>
<apply>
<minus />
<apply>
<times />
<apply>
<times />
<ci>k_aG</ci>
<apply>
<plus />
<ci>deltaG_0</ci>
<ci>rho_rG</ci>
</apply>
</apply>
<apply>
<minus />
<ci>G_TG</ci>
<ci>G</ci>
</apply>
</apply>
<apply>
<times />
<ci>k_dG</ci>
<ci>G</ci>
</apply>
</apply>
</apply>
</math>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq />
<apply>
<diff />
<bvar>
<ci>time</ci>
</bvar>
<ci>d_L</ci>
</apply>
<apply>
<divide />
<apply>
<minus />
<ci>dbar_L</ci>
<ci>d_L</ci>
</apply>
<ci>tau_dL</ci>
</apply>
</apply>
</math>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq />
<apply>
<diff />
<bvar>
<ci>time</ci>
</bvar>
<ci>f_L</ci>
</apply>
<apply>
<divide />
<apply>
<minus />
<ci>fbar_L</ci>
<ci>f_L</ci>
</apply>
<ci>tau_fL</ci>
</apply>
</apply>
</math>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq />
<apply>
<diff />
<bvar>
<ci>time</ci>
</bvar>
<ci>Ca_i</ci>
</apply>
<apply>
<times />
<apply>
<divide />
<apply>
<divide />
<apply>
<minus />
<apply>
<minus />
<apply>
<plus />
<ci>ICa_totm</ci>
<ci>I_SERCA</ci>
</apply>
<ci>I_rel</ci>
</apply>
<ci>I_IP3</ci>
</apply>
<apply>
<times />
<apply>
<times />
<ci>z_Ca</ci>
<ci>F</ci>
</apply>
<ci>Vol_Ca</ci>
</apply>
</apply>
<apply>
<plus />
<apply>
<plus />
<cn>1</cn>
<apply>
<divide />
<apply>
<times />
<ci>Sbar_CM</ci>
<ci>K_dCM</ci>
</apply>
<apply>
<power />
<apply>
<plus />
<ci>K_dCM</ci>
<ci>Ca_i</ci>
</apply>
<cn>2</cn>
</apply>
</apply>
</apply>
<apply>
<divide />
<apply>
<times />
<ci>Bbar_F</ci>
<ci>K_dB</ci>
</apply>
<apply>
<power />
<apply>
<plus />
<ci>K_dB</ci>
<ci>Ca_i</ci>
</apply>
<cn>2</cn>
</apply>
</apply>
</apply>
</apply>
<cn>-1</cn>
</apply>
</apply>
</math>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq />
<apply>
<diff />
<bvar>
<ci>time</ci>
</bvar>
<ci>p_f</ci>
</apply>
<apply>
<divide />
<apply>
<minus />
<ci>pbar_o</ci>
<ci>p_f</ci>
</apply>
<ci>tau_pf</ci>
</apply>
</apply>
</math>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq />
<apply>
<diff />
<bvar>
<ci>time</ci>
</bvar>
<ci>V_cGMP</ci>
</apply>
<apply>
<divide />
<apply>
<minus />
<ci>Vbar_cGMP</ci>
<ci>V_cGMP</ci>
</apply>
<ci>tau_sGC</ci>
</apply>
</apply>
</math>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq />
<apply>
<diff />
<bvar>
<ci>time</ci>
</bvar>
<ci>p_s</ci>
</apply>
<apply>
<divide />
<apply>
<minus />
<ci>pbar_o</ci>
<ci>p_s</ci>
</apply>
<ci>tau_ps</ci>
</apply>
</apply>
</math>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq />
<apply>
<diff />
<bvar>
<ci>time</ci>
</bvar>
<ci>cGMP_i</ci>
</apply>
<apply>
<minus />
<ci>V_cGMP</ci>
<apply>
<times />
<ci>k_pdecGMP</ci>
<apply>
<divide />
<apply>
<power />
<ci>cGMP_i</ci>
<cn>2</cn>
</apply>
<apply>
<plus />
<ci>cGMP_i</ci>
<ci>K_mpde</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</math>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq />
<apply>
<diff />
<bvar>
<ci>time</ci>
</bvar>
<ci>Na_i</ci>
</apply>
<apply>
<times />
<apply>
<divide />
<ci>INa_totm</ci>
<apply>
<times />
<ci>F</ci>
<ci>Vol_i</ci>
</apply>
</apply>
<cn>-1</cn>
</apply>
</apply>
</math>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq />
<apply>
<diff />
<bvar>
<ci>time</ci>
</bvar>
<ci>K_i</ci>
</apply>
<apply>
<times />
<apply>
<divide />
<ci>IK_totm</ci>
<apply>
<times />
<ci>F</ci>
<ci>Vol_i</ci>
</apply>
</apply>
<cn>-1</cn>
</apply>
</apply>
</math>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq />
<apply>
<diff />
<bvar>
<ci>time</ci>
</bvar>
<ci>Cl_i</ci>
</apply>
<apply>
<times />
<apply>
<divide />
<ci>ICl_totm</ci>
<apply>
<times />
<apply>
<times />
<ci>z_Cl</ci>
<ci>F</ci>
</apply>
<ci>Vol_i</ci>
</apply>
</apply>
<cn>-1</cn>
</apply>
</apply>
</math>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq />
<ci>E_K</ci>
<apply>
<times />
<apply>
<divide />
<cn>1</cn>
<apply>
<times />
<ci>z_K</ci>
<ci>FRT</ci>
</apply>
</apply>
<apply>
<ln />
<apply>
<divide />
<ci>K_e</ci>
<ci>K_i</ci>
</apply>
</apply>
</apply>
</apply>
</math>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq />
<apply>
<diff />
<bvar>
<ci>time</ci>
</bvar>
<ci>p_K</ci>
</apply>
<apply>
<divide />
<apply>
<minus />
<ci>pbar_K</ci>
<ci>p_K</ci>
</apply>
<ci>tau_pK</ci>
</apply>
</apply>
</math>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq />
<apply>
<diff />
<bvar>
<ci>time</ci>
</bvar>
<ci>q_1</ci>
</apply>
<apply>
<divide />
<apply>
<minus />
<ci>qbar</ci>
<ci>q_1</ci>
</apply>
<ci>tau_q1</ci>
</apply>
</apply>
</math>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq />
<apply>
<diff />
<bvar>
<ci>time</ci>
</bvar>
<ci>q_2</ci>
</apply>
<apply>
<divide />
<apply>
<minus />
<ci>qbar</ci>
<ci>q_2</ci>
</apply>
<ci>tau_q2</ci>
</apply>
</apply>
</math>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq />
<apply>
<diff />
<bvar>
<ci>time</ci>
</bvar>
<ci>P_SOC</ci>
</apply>
<apply>
<divide />
<apply>
<minus />
<ci>Pbar_SOC</ci>
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<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq />
<ci>ICa_NSC</ci>
<apply>
<times />
<apply>
<divide />
<apply>
<times />
<apply>
<times />
<apply>
<times />
<apply>
<times />
<apply>
<times />
<apply>
<times />
<apply>
<times />
<apply>
<times />
<ci>A_m</ci>
<ci>d_NSCmin</ci>
</apply>
<ci>Po_NSC</ci>
</apply>
<ci>PCa_NSC</ci>
</apply>
<ci>V_m</ci>
</apply>
<apply>
<power />
<ci>z_Ca</ci>
<cn>2</cn>
</apply>
</apply>
<ci>F</ci>
</apply>
<ci>FRT</ci>
</apply>
<apply>
<minus />
<ci>Ca_e</ci>
<apply>
<times />
<ci>Ca_i</ci>
<apply>
<exp />
<apply>
<times />
<apply>
<times />
<ci>z_Ca</ci>
<ci>V_m</ci>
</apply>
<ci>FRT</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<minus />
<cn>1</cn>
<apply>
<exp />
<apply>
<times />
<apply>
<times />
<ci>z_Ca</ci>
<ci>V_m</ci>
</apply>
<ci>FRT</ci>
</apply>
</apply>
</apply>
</apply>
<cn>1E6</cn>
</apply>
</apply>
</math>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq />
<ci>I_NSC</ci>
<apply>
<plus />
<apply>
<plus />
<ci>INa_NSC</ci>
<ci>IK_NSC</ci>
</apply>
<ci>ICa_NSC</ci>
</apply>
</apply>
</math>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq />
<ci>Pbar_SOC</ci>
<apply>
<divide />
<cn>1</cn>
<apply>
<plus />
<cn>1</cn>
<apply>
<divide />
<ci>Ca_u</ci>
<ci>K_SOC</ci>
</apply>
</apply>
</apply>
</apply>
</math>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq />
<ci>INa_SOC</ci>
<apply>
<times />
<apply>
<times />
<ci>gNa_SOC</ci>
<ci>P_SOC</ci>
</apply>
<apply>
<minus />
<ci>V_m</ci>
<ci>E_Na</ci>
</apply>
</apply>
</apply>
</math>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq />
<ci>ICa_SOC</ci>
<apply>
<times />
<apply>
<times />
<ci>gCa_SOC</ci>
<ci>P_SOC</ci>
</apply>
<apply>
<minus />
<ci>V_m</ci>
<ci>E_Ca</ci>
</apply>
</apply>
</apply>
</math>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq />
<ci>I_SOC</ci>
<apply>
<plus />
<ci>INa_SOC</ci>
<ci>ICa_SOC</ci>
</apply>
</apply>
</math>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq />
<ci>alpha_Cl</ci>
<apply>
<divide />
<apply>
<power />
<apply>
<divide />
<ci>cGMP_i</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mM">1</cn>
</apply>
<ci>n_ClcGMP</ci>
</apply>
<apply>
<plus />
<apply>
<power />
<apply>
<divide />
<ci>cGMP_i</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mM">1</cn>
</apply>
<ci>n_ClcGMP</ci>
</apply>
<apply>
<power />
<apply>
<divide />
<ci>K_ClcGMP</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mM">1</cn>
</apply>
<ci>n_ClcGMP</ci>
</apply>
</apply>
</apply>
</apply>
</math>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq />
<ci>K_ClCacGMP</ci>
<apply>
<times />
<apply>
<minus />
<cn>1</cn>
<apply>
<times />
<ci>alpha_Cl</ci>
<cn>.9</cn>
</apply>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mM">4E-4</cn>
</apply>
</apply>
</math>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq />
<ci>P_Cl</ci>
<apply>
<plus />
<apply>
<times />
<ci>R_ClcGMPmin</ci>
<apply>
<divide />
<apply>
<power />
<apply>
<divide />
<ci>Ca_i</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mM">1</cn>
</apply>
<ci>n_ClCa</ci>
</apply>
<apply>
<plus />
<apply>
<power />
<apply>
<divide />
<ci>Ca_i</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mM">1</cn>
</apply>
<ci>n_ClCa</ci>
</apply>
<apply>
<power />
<apply>
<divide />
<ci>K_ClCa</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mM">1</cn>
</apply>
<ci>n_ClCa</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<times />
<ci>alpha_Cl</ci>
<apply>
<divide />
<apply>
<power />
<apply>
<divide />
<ci>Ca_i</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mM">1</cn>
</apply>
<ci>n_ClCa</ci>
</apply>
<apply>
<plus />
<apply>
<power />
<apply>
<divide />
<ci>Ca_i</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mM">1</cn>
</apply>
<ci>n_ClCa</ci>
</apply>
<apply>
<power />
<apply>
<divide />
<ci>K_ClCacGMP</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mM">1</cn>
</apply>
<ci>n_ClCa</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
</math>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq />
<ci>I_ClCa</ci>
<apply>
<times />
<apply>
<times />
<apply>
<times />
<ci>C_m</ci>
<ci>g_ClCa</ci>
</apply>
<ci>P_Cl</ci>
</apply>
<apply>
<minus />
<ci>V_m</ci>
<ci>E_Cl</ci>
</apply>
</apply>
</apply>
</math>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq />
<ci>I_PMCA</ci>
<apply>
<times />
<ci>Ibar_PMCA</ci>
<apply>
<divide />
<ci>Ca_i</ci>
<apply>
<plus />
<ci>Ca_i</ci>
<ci>K_mPMCA</ci>
</apply>
</apply>
</apply>
</apply>
</math>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq />
<ci>R_NCXcGMP</ci>
<apply>
<plus />
<cn>1</cn>
<apply>
<times />
<apply>
<divide />
<ci>cGMP_i</ci>
<apply>
<plus />
<ci>cGMP_i</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mM">.045</cn>
</apply>
</apply>
<cn>.55</cn>
</apply>
</apply>
</apply>
</math>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq />
<ci>phi_F</ci>
<apply>
<exp />
<apply>
<times />
<apply>
<times />
<ci>gamma_NCX</ci>
<ci>V_m</ci>
</apply>
<ci>FRT</ci>
</apply>
</apply>
</apply>
</math>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq />
<ci>phi_R</ci>
<apply>
<exp />
<apply>
<times />
<apply>
<times />
<apply>
<minus />
<ci>gamma_NCX</ci>
<cn>1</cn>
</apply>
<ci>V_m</ci>
</apply>
<ci>FRT</ci>
</apply>
</apply>
</apply>
</math>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq />
<ci>I_NCX</ci>
<apply>
<divide />
<apply>
<times />
<apply>
<times />
<ci>g_NCX</ci>
<ci>R_NCXcGMP</ci>
</apply>
<apply>
<minus />
<apply>
<times />
<apply>
<times />
<apply>
<power />
<ci>Na_i</ci>
<cn>3</cn>
</apply>
<ci>Ca_e</ci>
</apply>
<ci>phi_F</ci>
</apply>
<apply>
<times />
<apply>
<times />
<apply>
<power />
<ci>Na_e</ci>
<cn>3</cn>
</apply>
<ci>Ca_i</ci>
</apply>
<ci>phi_R</ci>
</apply>
</apply>
</apply>
<apply>
<plus />
<cn>1</cn>
<apply>
<times />
<ci>d_NCX</ci>
<apply>
<plus />
<apply>
<times />
<apply>
<power />
<ci>Na_e</ci>
<cn>3</cn>
</apply>
<ci>Ca_i</ci>
</apply>
<apply>
<times />
<apply>
<power />
<ci>Na_i</ci>
<cn>3</cn>
</apply>
<ci>Ca_e</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
</math>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq />
<ci>I_NaK</ci>
<apply>
<divide />
<apply>
<times />
<apply>
<divide />
<apply>
<times />
<apply>
<divide />
<apply>
<times />
<apply>
<times />
<apply>
<times />
<ci>C_m</ci>
<ci>Ibar_NaK</ci>
</apply>
<ci>Q</ci>
</apply>
<apply>
<power />
<apply>
<divide />
<ci>K_e</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mM">1</cn>
</apply>
<ci>n_HKe</ci>
</apply>
</apply>
<apply>
<plus />
<apply>
<power />
<apply>
<divide />
<ci>K_e</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mM">1</cn>
</apply>
<ci>n_HKe</ci>
</apply>
<apply>
<power />
<apply>
<divide />
<ci>K_dKe</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mM">1</cn>
</apply>
<ci>n_HKe</ci>
</apply>
</apply>
</apply>
<apply>
<power />
<apply>
<divide />
<ci>Na_i</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mM">1</cn>
</apply>
<ci>n_HNai</ci>
</apply>
</apply>
<apply>
<plus />
<apply>
<power />
<apply>
<divide />
<ci>Na_i</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mM">1</cn>
</apply>
<ci>n_HNai</ci>
</apply>
<apply>
<power />
<apply>
<divide />
<ci>Na_dNai</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mM">1</cn>
</apply>
<ci>n_HNai</ci>
</apply>
</apply>
</apply>
<apply>
<plus />
<ci>V_m</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mV">150</cn>
</apply>
</apply>
<apply>
<plus />
<ci>V_m</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mV">200</cn>
</apply>
</apply>
</apply>
</math>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq />
<ci>R_NaKClcGMP</ci>
<apply>
<plus />
<cn>1</cn>
<apply>
<times />
<apply>
<divide />
<ci>cGMP_i</ci>
<apply>
<plus />
<ci>cGMP_i</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mM">.0064</cn>
</apply>
</apply>
<cn>3.5</cn>
</apply>
</apply>
</apply>
</math>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq />
<ci>ICl_NaKCl</ci>
<apply>
<times />
<apply>
<times />
<apply>
<times />
<apply>
<times />
<apply>
<times />
<apply>
<times />
<apply>
<times />
<ci>R_NaKClcGMP</ci>
<ci>z_Cl</ci>
</apply>
<ci>A_m</ci>
</apply>
<ci>L_NaKCl</ci>
</apply>
<ci>F</ci>
</apply>
<ci>RT</ci>
</apply>
<apply>
<log />
<apply>
<times />
<apply>
<times />
<apply>
<divide />
<ci>Na_e</ci>
<ci>Na_i</ci>
</apply>
<apply>
<divide />
<ci>K_e</ci>
<ci>K_i</ci>
</apply>
</apply>
<apply>
<power />
<apply>
<divide />
<ci>Cl_e</ci>
<ci>Cl_i</ci>
</apply>
<cn>2</cn>
</apply>
</apply>
</apply>
</apply>
<cn>-1E9</cn>
</apply>
</apply>
</math>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq />
<ci>INa_NaKCl</ci>
<apply>
<times />
<ci>ICl_NaKCl</ci>
<cn>-0.5</cn>
</apply>
</apply>
</math>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq />
<ci>IK_NaKCl</ci>
<apply>
<times />
<ci>ICl_NaKCl</ci>
<cn>-0.5</cn>
</apply>
</apply>
</math>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq />
<ci>OPtot_IP3</ci>
<apply>
<power />
<apply>
<times />
<apply>
<times />
<apply>
<divide />
<ci>IP3</ci>
<apply>
<plus />
<ci>IP3</ci>
<ci>K_IP3</ci>
</apply>
</apply>
<apply>
<divide />
<ci>Ca_i</ci>
<apply>
<plus />
<ci>Ca_i</ci>
<ci>K_actIP3</ci>
</apply>
</apply>
</apply>
<ci>h_IP3</ci>
</apply>
<cn>3</cn>
</apply>
</apply>
</math>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq />
<ci>I_IP3</ci>
<apply>
<times />
<apply>
<times />
<apply>
<times />
<apply>
<times />
<apply>
<times />
<ci>Ibar_IP3</ci>
<ci>z_Ca</ci>
</apply>
<ci>Vol_Ca</ci>
</apply>
<ci>F</ci>
</apply>
<ci>OPtot_IP3</ci>
</apply>
<apply>
<minus />
<ci>Ca_u</ci>
<ci>Ca_i</ci>
</apply>
</apply>
</apply>
</math>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq />
<ci>I_SERCA</ci>
<apply>
<times />
<ci>Ibar_SERCA</ci>
<apply>
<divide />
<ci>Ca_i</ci>
<apply>
<plus />
<ci>Ca_i</ci>
<ci>K_mup</ci>
</apply>
</apply>
</apply>
</apply>
</math>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq />
<ci>I_tr</ci>
<apply>
<divide />
<apply>
<times />
<apply>
<times />
<apply>
<times />
<apply>
<minus />
<ci>Ca_u</ci>
<ci>Ca_r</ci>
</apply>
<ci>z_Ca</ci>
</apply>
<ci>F</ci>
</apply>
<ci>Vol_SRu</ci>
</apply>
<ci>tau_tr</ci>
</apply>
</apply>
</math>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq />
<ci>I_rel</ci>
<apply>
<divide />
<apply>
<times />
<apply>
<times />
<apply>
<times />
<apply>
<times />
<apply>
<plus />
<apply>
<power />
<ci>R_10</ci>
<cn>2</cn>
</apply>
<ci>R_leak</ci>
</apply>
<apply>
<minus />
<ci>Ca_r</ci>
<ci>Ca_i</ci>
</apply>
</apply>
<ci>z_Ca</ci>
</apply>
<ci>F</ci>
</apply>
<ci>Vol_SRr</ci>
</apply>
<ci>tau_rel</ci>
</apply>
</apply>
</math>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq />
<ci>R_00</ci>
<apply>
<minus />
<apply>
<minus />
<apply>
<minus />
<cn>1</cn>
<ci>R_10</ci>
</apply>
<ci>R_11</ci>
</apply>
<ci>R_01</ci>
</apply>
</apply>
</math>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq />
<ci>R_supSG0</ci>
<apply>
<times />
<ci>R_TG</ci>
<ci>xi_G</ci>
</apply>
</apply>
</math>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq />
<ci>PIP2_0</ci>
<apply>
<minus />
<ci>PIP2_T</ci>
<apply>
<times />
<apply>
<times />
<apply>
<times />
<apply>
<plus />
<cn>1</cn>
<apply>
<divide />
<ci>k_degG</ci>
<ci>r_rG</ci>
</apply>
</apply>
<ci>gamma_G</ci>
</apply>
<ci>IP3_0</ci>
</apply>
<cn>1E-15</cn>
</apply>
</apply>
</apply>
</math>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq />
<ci>r_hG0</ci>
<apply>
<divide />
<apply>
<times />
<apply>
<times />
<ci>k_degG</ci>
<ci>gamma_G</ci>
</apply>
<ci>IP3_0</ci>
</apply>
<ci>PIP2_0</ci>
</apply>
</apply>
</math>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq />
<ci>G_0</ci>
<apply>
<times />
<apply>
<divide />
<apply>
<times />
<ci>r_hG0</ci>
<apply>
<plus />
<ci>K_cG</ci>
<ci>Ca_i0</ci>
</apply>
</apply>
<apply>
<times />
<ci>alpha_G</ci>
<ci>Ca_i0</ci>
</apply>
</apply>
<cn>1E-15</cn>
</apply>
</apply>
</math>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq />
<ci>rho_rG</ci>
<apply>
<divide />
<apply>
<times />
<ci>NE</ci>
<ci>R_supSG</ci>
</apply>
<apply>
<times />
<apply>
<times />
<ci>xi_G</ci>
<ci>R_TG</ci>
</apply>
<apply>
<plus />
<ci>K_1G</ci>
<ci>NE</ci>
</apply>
</apply>
</apply>
</apply>
</math>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq />
<ci>r_hG</ci>
<apply>
<times />
<apply>
<times />
<ci>alpha_G</ci>
<apply>
<divide />
<ci>Ca_i</ci>
<apply>
<plus />
<ci>Ca_i</ci>
<ci>K_cG</ci>
</apply>
</apply>
</apply>
<ci>G</ci>
</apply>
</apply>
</math>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq />
<ci>Vbar_cGMP</ci>
<apply>
<divide />
<apply>
<times />
<ci>V_cGMPmax</ci>
<apply>
<plus />
<apply>
<times />
<ci>B5_sGC</ci>
<ci>NO</ci>
</apply>
<apply>
<power />
<ci>NO</ci>
<cn>2</cn>
</apply>
</apply>
</apply>
<apply>
<plus />
<apply>
<plus />
<ci>A0_sGC</ci>
<apply>
<times />
<ci>A1_sGC</ci>
<ci>NO</ci>
</apply>
</apply>
<apply>
<power />
<ci>NO</ci>
<cn>2</cn>
</apply>
</apply>
</apply>
</apply>
</math>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq />
<ci>tau_sGC</ci>
<piecewise>
<piece>
<apply>
<divide />
<cn>1</cn>
<apply>
<plus />
<apply>
<times />
<ci>k_3sGC</ci>
<ci>NO</ci>
</apply>
<ci>k_DrsGC</ci>
</apply>
</apply>
<apply>
<or />
<apply>
<eq />
<apply>
<minus />
<ci>Vbar_cGMP</ci>
<ci>V_cGMP</ci>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mM_per_ms">0</cn>
</apply>
<apply>
<gt />
<apply>
<minus />
<ci>Vbar_cGMP</ci>
<ci>V_cGMP</ci>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mM_per_ms">0</cn>
</apply>
</apply>
</piece>
<otherwise>
<apply>
<divide />
<cn>1</cn>
<apply>
<plus />
<ci>k_m2sGC</ci>
<ci>k_DrsGC</ci>
</apply>
</apply>
</otherwise>
</piecewise>
</apply>
</math>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq />
<ci>ICa_totm</ci>
<apply>
<plus />
<apply>
<plus />
<apply>
<minus />
<apply>
<plus />
<ci>ICa_SOC</ci>
<ci>I_VOCC</ci>
</apply>
<apply>
<times />
<ci>I_NCX</ci>
<cn>2</cn>
</apply>
</apply>
<ci>I_PMCA</ci>
</apply>
<ci>ICa_NSC</ci>
</apply>
</apply>
</math>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq />
<ci>INa_totm</ci>
<apply>
<plus />
<apply>
<plus />
<apply>
<plus />
<apply>
<plus />
<ci>INa_NaKCl</ci>
<ci>INa_SOC</ci>
</apply>
<apply>
<times />
<ci>I_NaK</ci>
<cn>3</cn>
</apply>
</apply>
<apply>
<times />
<ci>I_NCX</ci>
<cn>3</cn>
</apply>
</apply>
<ci>INa_NSC</ci>
</apply>
</apply>
</math>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq />
<ci>IK_totm</ci>
<apply>
<minus />
<apply>
<plus />
<apply>
<plus />
<apply>
<plus />
<apply>
<plus />
<ci>IK_NaKCl</ci>
<ci>I_BKCa</ci>
</apply>
<ci>I_Kv</ci>
</apply>
<ci>IK_NSC</ci>
</apply>
<ci>I_Kleak</ci>
</apply>
<apply>
<times />
<ci>I_NaK</ci>
<cn>2</cn>
</apply>
</apply>
</apply>
</math>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq />
<ci>ICl_totm</ci>
<apply>
<plus />
<ci>ICl_NaKCl</ci>
<ci>I_ClCa</ci>
</apply>
</apply>
</math>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq />
<ci>NO</ci>
<piecewise>
<piece>
<ci>NO_base</ci>
<apply>
<or />
<apply>
<eq />
<ci>time</ci>
<cn>0</cn>
</apply>
<apply>
<gt />
<ci>time</ci>
<cn>0</cn>
</apply>
</apply>
</piece>
<otherwise>
<cn>0</cn>
</otherwise>
</piecewise>
</apply>
</math>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq />
<ci>NE</ci>
<piecewise>
<piece>
<cn>0</cn>
<apply>
<or />
<apply>
<lt />
<ci>time</ci>
<cn>1.1E5</cn>
</apply>
<apply>
<or />
<apply>
<eq />
<ci>time</ci>
<cn>175000</cn>
</apply>
<apply>
<gt />
<ci>time</ci>
<cn>175000</cn>
</apply>
</apply>
</apply>
</piece>
<otherwise>
<ci>NE_amp</ci>
</otherwise>
</piecewise>
</apply>
</math>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq />
<ci>deltaG_0</ci>
<apply>
<divide />
<apply>
<times />
<ci>k_dG</ci>
<ci>G_0</ci>
</apply>
<apply>
<times />
<ci>k_aG</ci>
<apply>
<minus />
<ci>G_TG</ci>
<ci>G_0</ci>
</apply>
</apply>
</apply>
</apply>
</math>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq />
<ci>I_stim</ci>
<piecewise>
<piece>
<ci>Istim_amp</ci>
<apply>
<or />
<apply>
<eq />
<ci>time</ci>
<cn>0</cn>
</apply>
<apply>
<gt />
<ci>time</ci>
<cn>0</cn>
</apply>
</apply>
</piece>
<otherwise>
<cn>0</cn>
</otherwise>
</piecewise>
</apply>
</math>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq />
<ci>d_L0</ci>
<apply>
<divide />
<cn>1</cn>
<apply>
<plus />
<cn>1</cn>
<apply>
<exp />
<apply>
<times />
<apply>
<divide />
<ci>V_m0</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mV">8.3</cn>
</apply>
<cn>-1</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</math>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq />
<ci>f_L0</ci>
<apply>
<divide />
<cn>1</cn>
<apply>
<plus />
<cn>1</cn>
<apply>
<exp />
<apply>
<divide />
<apply>
<plus />
<ci>V_m0</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mV">42</cn>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mV">9.1</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</math>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq />
<ci>R_NO0</ci>
<apply>
<divide />
<ci>NO_0</ci>
<apply>
<plus />
<ci>NO_0</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mM">2E-4</cn>
</apply>
</apply>
</apply>
</math>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq />
<ci>R_cGMP0</ci>
<apply>
<divide />
<apply>
<power />
<ci>cGMP_i0</ci>
<cn>2</cn>
</apply>
<apply>
<plus />
<apply>
<power />
<ci>cGMP_i0</ci>
<cn>2</cn>
</apply>
<apply>
<times />
<apply>
<power />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="uM">5.5E-4</cn>
<cn>2</cn>
</apply>
<cn>1E-6</cn>
</apply>
</apply>
</apply>
</apply>
</math>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq />
<ci>V_50KCa0</ci>
<apply>
<minus />
<apply>
<minus />
<apply>
<minus />
<apply>
<times />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mV">-41.7</cn>
<apply>
<log />
<apply>
<divide />
<ci>Ca_i0</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mM">1</cn>
</apply>
</apply>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mV">128.2</cn>
</apply>
<apply>
<times />
<ci>dV_50KCaNO</ci>
<ci>R_NO0</ci>
</apply>
</apply>
<apply>
<times />
<ci>dV_50KCacGMP</ci>
<ci>R_cGMP0</ci>
</apply>
</apply>
</apply>
</math>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq />
<ci>p_f0</ci>
<apply>
<divide />
<cn>1</cn>
<apply>
<plus />
<cn>1</cn>
<apply>
<exp />
<apply>
<times />
<apply>
<divide />
<apply>
<minus />
<ci>V_m0</ci>
<ci>V_50KCa0</ci>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mV">18.25</cn>
</apply>
<cn>-1</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</math>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq />
<ci>p_s0</ci>
<apply>
<divide />
<cn>1</cn>
<apply>
<plus />
<cn>1</cn>
<apply>
<exp />
<apply>
<times />
<apply>
<divide />
<apply>
<minus />
<ci>V_m0</ci>
<ci>V_50KCa0</ci>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mV">18.25</cn>
</apply>
<cn>-1</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</math>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq />
<ci>p_K0</ci>
<apply>
<divide />
<cn>1</cn>
<apply>
<plus />
<cn>1</cn>
<apply>
<exp />
<apply>
<times />
<apply>
<divide />
<apply>
<plus />
<ci>V_m0</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mV">11</cn>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mV">15</cn>
</apply>
<cn>-1</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</math>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq />
<ci>q_10</ci>
<apply>
<divide />
<cn>1</cn>
<apply>
<plus />
<cn>1</cn>
<apply>
<exp />
<apply>
<divide />
<apply>
<plus />
<ci>V_m0</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mV">40</cn>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mV">14</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</math>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq />
<ci>q_20</ci>
<apply>
<divide />
<cn>1</cn>
<apply>
<plus />
<cn>1</cn>
<apply>
<exp />
<apply>
<divide />
<apply>
<plus />
<ci>V_m0</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mV">40</cn>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="mV">14</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</math>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq />
<ci>h_IP30</ci>
<apply>
<divide />
<ci>K_inhIP3</ci>
<apply>
<plus />
<ci>Ca_i0</ci>
<ci>K_inhIP3</ci>
</apply>
</apply>
</apply>
</math>
</component>
<connection>
<map_components component_1="environment" component_2="Kapela" />
<map_variables variable_1="time" variable_2="time" />
</connection>
</model>
