- Author:
- Win <wtun899@aucklanduni.ac.nz>
- Date:
- 2017-11-03 13:12:22+13:00
- Desc:
- adding new readme file
- Permanent Source URI:
- https://models.physiomeproject.org/workspace/4cd/rawfile/f588d2c254ad507a91480429cfb49944e0b6718a/ReadMe.rst.txt
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**A model of Feto-maternal capillary gas exchange**
**Model Status**
This CellML model has been built from a mathematical model of placental oxygen transfer by Ester Hill, Gondon Power and Lawrence Longo (1972). This file is know to run in openCOR. The parameters in Table 1 of the paper has been changed to make them consistent with human placenta.
**Model structure**
During pregnancy, the placenta acts as the fetal lung as the gas exchange between mother and fetus occurs at the placental capillaries. This gas exchange is controlled by multiple factors such as partial pressure of oxygen, blood volume, blood flow rate, hemoglobin concentration and oxygen diffusivity. The model predicts the oxygen gain by the fetal blood and the oxygen loss by maternal blood over capillary transit time.
.. image:: C:\Users\wtun899\Desktop\fig1pmr
A schematic diagram of feto-maternal gas exchange at placental capillary: deoxygenated blood carried by fetal artery enters into the capillary where the diffusion of maternal blood oxygen occurs. Due to this oxygen gain, the fetal blood is well oxygenated after the exchange which is carried towards the fetus by the fetal vein.
.. image:: C:\Users\wtun899\Desktop\pmr insert
This top graph shows change in partial pressure of mother and fetus during capillary transit time. The bottom graph shows the change in oxyhaemoglobin mother and fetus with during capillary transit time.
The original paper reference is cited below:
Hill, E.P., G.G. Power, and L.D. Longo, A mathematical model of carbon dioxide transfer in the placenta and its interaction with oxygen. Am J Physiol, 1973. 224(2): p. 283-99.
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Feto_maternal_Oxygen_transfer model predicts the gas exchange between fetal capillary and maternal blood during capillary transit time. The maternal partial pressure of oxygen is decreased and the fetal partial pressure of oxygen is increased with time. Parallel to partial pressure of oxygen, the oxygen saturation of mother and fetus is decreased and increased respectively.
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