- Author:
- Soroush Safaei <ssaf006@aucklanduni.ac.nz>
- Date:
- 2018-07-19 07:50:03+12:00
- Desc:
- Merge remote-tracking branch 'origin/master'
- Permanent Source URI:
- https://models.physiomeproject.org/workspace/483/rawfile/f81c1d034d819d4b5746270a6c34032c144f8033/Original/Parameters-min.cellml
<?xml version='1.0'?>
<model name="Parameters" xmlns="http://www.cellml.org/cellml/1.1#" xmlns:cellml="http://www.cellml.org/cellml/1.1#">
<component name="param1">
<!-- V_G: distribution volume of Glucose
V_I: distribution volume of Insulin
k_abs: rate of intestinal absorption
k_gri: rate of grinding
f: fraction of intestinal absorption appears in plasma
k_p1: extrapolated EGP at zero Glucose and Insulin
k_p2: liver Glucose effectiveness
k_p3: amplitude of Insulin action on liver
k_p4: amplitude of portal Insulin action on liver
k_i: delay between Insulin signal and Insulin action
U_ii: Glucose Insulin independent utilisation
p_2U: rate constant of Insulin action on the peripheral Glucose utilisation
K: pancreatic responsivity to Glucose rate of change
alpha: delay between Glucose signal & Insulin secretion
beta: pancreatic responsivity to Glucose
gamma: transfer rate constant between portalvein & liver
BW: body weight
D: ingested Glucose mass-->
<variable initial_value="1.88" name="V_G" public_interface="out" units="dl_per_kg"/>
<variable initial_value="0.065" name="k_1" public_interface="out" units="per_minute"/>
<variable initial_value="0.079" name="k_2" public_interface="out" units="per_minute"/>
<variable initial_value="0.05" name="V_I" public_interface="out" units="l_per_kg"/>
<variable initial_value="0.19" name="m_1" public_interface="out" units="per_minute"/>
<variable initial_value="0.484" name="m_2" public_interface="out" units="per_minute"/>
<variable initial_value="0.194" name="m_4" public_interface="out" units="per_minute"/>
<variable initial_value="0.0304" name="m_5" public_interface="out" units="minute_kg_per_pmol"/>
<variable initial_value="0.6471" name="m_6" public_interface="out" units="dimensionless"/>
<variable initial_value="0.6" name="HE_b" public_interface="out" units="dimensionless"/>
<variable initial_value="0.0558" name="k_max" public_interface="out" units="per_minute"/>
<variable initial_value="0.008" name="k_min" public_interface="out" units="per_minute"/>
<variable initial_value="0.057" name="k_abs" public_interface="out" units="per_minute"/>
<variable initial_value="0.0558" name="k_gri" public_interface="out" units="per_minute"/>
<variable initial_value="0.9" name="f" public_interface="out" units="dimensionless"/>
<variable initial_value="0.82" name="b" public_interface="out" units="dimensionless"/>
<variable initial_value="0.01" name="d" public_interface="out" units="dimensionless"/>
<variable initial_value="2.7" name="k_p1" public_interface="out" units="mg_per_kg_minute"/>
<variable initial_value="0.0021" name="k_p2" public_interface="out" units="per_minute"/>
<variable initial_value="0.009" name="k_p3" public_interface="out" units="mg_l_per_kg_minute_pmol"/>
<variable initial_value="0.0618" name="k_p4" public_interface="out" units="mg_per_minute_pmol"/>
<variable initial_value="0.0079" name="k_i" public_interface="out" units="per_minute"/>
<variable initial_value="1" name="U_ii" public_interface="out" units="mg_per_kg_minute"/>
<variable initial_value="2.5" name="V_m0" public_interface="out" units="mg_per_kg_minute"/>
<variable initial_value="0.047" name="V_mX" public_interface="out" units="mg_l_per_kg_minute_pmol"/>
<variable initial_value="225.59" name="K_m0" public_interface="out" units="mg_per_kg"/>
<variable initial_value="0.0331" name="p_2U" public_interface="out" units="per_minute"/>
<variable initial_value="0.2" name="part" public_interface="out" units="dimensionless"/>
<variable initial_value="2.3" name="K" public_interface="out" units="pmol_dl_per_kg_mg"/>
<variable initial_value="0.05" name="alpha" public_interface="out" units="per_minute"/>
<variable initial_value="0.11" name="beta" public_interface="out" units="pmol_dl_per_kg_mg_minute"/>
<variable initial_value="0.5" name="gamma" public_interface="out" units="per_minute"/>
<variable initial_value="78" name="BW" public_interface="out" units="kilogram"/>
<variable initial_value="78000" name="D" public_interface="out" units="mg"/>
<variable initial_value="95" name="G_b" public_interface="out" units="mg_per_dl"/>
<variable initial_value="25" name="I_b" public_interface="out" units="pmol_per_l"/>
<variable initial_value="1.8" name="S_b" public_interface="out" units="pmol_per_kg_minute"/>
</component>
<component name="param2">
<variable initial_value="0.009645863" name="k21" public_interface="out" units="per_minute"/>
<variable initial_value="2374.9773277896" name="k22" public_interface="out" units="dimensionless"/>
<variable initial_value="0.1199" name="k23" public_interface="out" units="dimensionless"/>
<variable initial_value="0.9431" name="k24" public_interface="out" units="dimensionless"/>
<variable initial_value="608.584" name="k2b" public_interface="out" units="per_minute"/>
<variable initial_value="8.1119" name="k3f" public_interface="out" units="per_minute"/>
<variable initial_value="0.1895" name="k3b" public_interface="out" units="per_minute"/>
<variable initial_value="384885.688" name="k4f" public_interface="out" units="per_minute"/>
<variable initial_value="28137.07" name="k4b" public_interface="out" units="per_minute"/>
<variable initial_value="64300.071" name="k5f" public_interface="out" units="per_minute"/>
<variable initial_value="10052.5084" name="k5b" public_interface="out" units="per_minute"/>
<variable initial_value="16094201.79" name="k6f" public_interface="out" units="per_minute"/>
<variable initial_value="77.77121" name="k6b" public_interface="out" units="per_minute"/>
<variable initial_value="4174.63" name="k7f" public_interface="out" units="per_minute"/>
<variable initial_value="565342.162" name="k7b" public_interface="out" units="per_minute"/>
<variable initial_value="1515762.42" name="k8f" public_interface="out" units="per_minute"/>
<variable initial_value="300.751" name="k8b" public_interface="out" units="per_minute"/>
<variable initial_value="8.14e-8" name="k91" public_interface="out" units="per_minute"/>
<variable initial_value="0.0281" name="k92" public_interface="out" units="per_minute"/>
<variable initial_value="4.02976" name="k9b" public_interface="out" units="per_minute"/>
<variable initial_value="2.34e-8" name="k5BasicWb" public_interface="out" units="per_minute"/>
<variable initial_value="0.2966" name="k_glut1" public_interface="out" units="mg_per_kg_minute"/>
<variable initial_value="31.42" name="k_glut4" public_interface="out" units="mg_per_kg_minute"/>
<variable initial_value="132.77" name="KmG1" public_interface="out" units="mg_per_kg"/>
<variable initial_value="70.4032" name="KmG4" public_interface="out" units="mg_per_kg"/>
<variable initial_value="0.00312" name="kbf" public_interface="out" units="mg_l_per_kg_minute_pmol"/>
</component>
<component name="param3">
<variable initial_value="448251462.712" name="a1" public_interface="out" units="l_per_mol_minute"/>
<variable initial_value="4321891.903" name="a2" public_interface="out" units="l_per_mol_minute"/>
<variable initial_value="0.7722612342" name="d1" public_interface="out" units="per_minute"/>
<variable initial_value="0.012205776" name="d2" public_interface="out" units="per_minute"/>
<variable initial_value="0.001364" name="K_cr" public_interface="out" units="per_minute"/>
<variable initial_value="37.0819" name="K_ex" public_interface="out" units="per_minute"/>
<variable initial_value="30.6825" name="K_end" public_interface="out" units="per_minute"/>
<variable initial_value="0.00095" name="K_dp" public_interface="out" units="per_minute"/>
<variable initial_value="237.5189" name="K_cat" public_interface="out" units="per_minute"/>
<variable initial_value="3.01819" name="K_m" public_interface="out" units="dimensionless"/>
<variable initial_value="0.49752" name="kfbasal" public_interface="out" units="per_minute"/>
<variable initial_value="128042.88" name="krbasal" public_interface="out" units="per_minute"/>
<variable initial_value="1400" name="K4" public_interface="out" units="l_per_mol_minute"/>
<variable initial_value="0.01" name="K8" public_interface="out" units="per_minute"/>
</component>
</model>
