- Author:
- Soroush Safaei <ssaf006@aucklanduni.ac.nz>
- Date:
- 2018-07-19 07:50:03+12:00
- Desc:
- Merge remote-tracking branch 'origin/master'
- Permanent Source URI:
- https://models.physiomeproject.org/workspace/483/rawfile/f81c1d034d819d4b5746270a6c34032c144f8033/BondGraph/Parameters.cellml
<?xml version='1.0'?>
<model name="Parameters" xmlns="http://www.cellml.org/cellml/1.1#" xmlns:cellml="http://www.cellml.org/cellml/1.1#">
<component name="param1">
<!-- V_G: distribution volume of Glucose
V_I: distribution volume of Insulin
k_abs: rate of intestinal absorption
k_gri: rate of grinding
f: fraction of intestinal absorption appears in plasma
k_p1: extrapolated EGP at zero Glucose and Insulin
k_p2: liver Glucose effectiveness
k_p3: amplitude of Insulin action on liver
k_p4: amplitude of portal Insulin action on liver
k_i: delay between Insulin signal and Insulin action
U_ii: Glucose Insulin independent utilisation
p_2U: rate constant of Insulin action on the peripheral Glucose utilisation
K: pancreatic responsivity to Glucose rate of change
alpha: delay between Glucose signal & Insulin secretion
beta: pancreatic responsivity to Glucose
gamma: transfer rate constant between portalvein & liver
BW: body weight
D: ingested Glucose mass-->
<variable initial_value="0.188" name="V_G" public_interface="out" units="litre"/>
<variable initial_value="0.05" name="V_I" public_interface="out" units="litre"/>
<variable initial_value="0.001083" name="k_1" public_interface="out" units="per_s"/>
<variable initial_value="0.001317" name="k_2" public_interface="out" units="per_s"/>
<variable initial_value="0.00317" name="m_1" public_interface="out" units="per_s"/>
<variable initial_value="0.00807" name="m_2" public_interface="out" units="per_s"/>
<variable initial_value="0.00323" name="m_4" public_interface="out" units="per_s"/>
<variable initial_value="1.824" name="m_5" public_interface="out" units="s_per_pmol"/>
<variable initial_value="0.6471" name="m_6" public_interface="out" units="dimensionless"/>
<variable initial_value="0.00093" name="k_max" public_interface="out" units="per_s"/>
<variable initial_value="0.00013" name="k_min" public_interface="out" units="per_s"/>
<variable initial_value="0.00095" name="k_abs" public_interface="out" units="per_s"/>
<variable initial_value="0.00093" name="k_gri" public_interface="out" units="per_s"/>
<variable initial_value="0.9" name="f" public_interface="out" units="dimensionless"/>
<variable initial_value="0.82" name="b" public_interface="out" units="dimensionless"/>
<variable initial_value="0.01" name="d" public_interface="out" units="dimensionless"/>
<variable initial_value="78" name="BW" public_interface="out" units="kilogram"/>
<variable initial_value="78" name="D" public_interface="out" units="gram"/>
<variable initial_value="0.045e-3" name="k_p1" public_interface="out" units="g_per_s"/>
<variable initial_value="0.035e-3" name="k_p2" public_interface="out" units="per_s"/>
<variable initial_value="0.15e-6" name="k_p3" public_interface="out" units="g_per_s_pM"/>
<variable initial_value="1.03e-6" name="k_p4" public_interface="out" units="g_per_s_pmol"/>
<variable initial_value="0.000132" name="k_i" public_interface="out" units="per_s"/>
<variable initial_value="0.01667e-3" name="U_ii" public_interface="out" units="g_per_s"/>
<variable initial_value="0.04167e-3" name="v_m0" public_interface="out" units="g_per_s"/>
<variable initial_value="0.7833e-6" name="v_mX" public_interface="out" units="g_per_s_pM"/>
<variable initial_value="0.22559" name="k_m0" public_interface="out" units="gram"/>
<variable initial_value="0.000552" name="k_p" public_interface="out" units="per_s"/>
<variable initial_value="0.2" name="part" public_interface="out" units="dimensionless"/>
<variable initial_value="230" name="k" public_interface="out" units="pmol_l_per_g"/>
<variable initial_value="0.1833" name="beta" public_interface="out" units="pmol_l_per_g_s"/>
<variable initial_value="0.000833" name="alpha" public_interface="out" units="per_s"/>
<variable initial_value="0.008333" name="gamma" public_interface="out" units="per_s"/>
<variable initial_value="0.95" name="G_b" public_interface="out" units="g_per_l"/>
<variable initial_value="25" name="I_b" public_interface="out" units="pM"/>
<variable initial_value="0.03" name="S_b" public_interface="out" units="pmol_per_s"/>
<variable initial_value="0.6" name="HE_b" public_interface="out" units="dimensionless"/>
</component>
<!-- def comp param2 as
var k21: per_minute {init: 0.009645863, pub: out};
var k22: dimensionless {init: 2374.9773277896, pub: out};
var k23: dimensionless {init: 0.1199, pub: out};
var k24: dimensionless {init: 0.9431, pub: out};
var k2b: per_minute {init: 608.584, pub: out};
var k3f: per_minute {init: 8.1119, pub: out};
var k3b: per_minute {init: 0.1895, pub: out};
var k4f: per_minute {init: 384885.688, pub: out};
var k4b: per_minute {init: 28137.07, pub: out};
var k5f: per_minute {init: 64300.071, pub: out};
var k5b: per_minute {init: 10052.5084, pub: out};
var k6f: per_minute {init: 16094201.79, pub: out};
var k6b: per_minute {init: 77.77121, pub: out};
var k7f: per_minute {init: 4174.63, pub: out};
var k7b: per_minute {init: 565342.162, pub: out};
var k8f: per_minute {init: 1515762.42, pub: out};
var k8b: per_minute {init: 300.751, pub: out};
var k91: per_minute {init: 8.14e-8, pub: out};
var k92: per_minute {init: 0.0281, pub: out};
var k9b: per_minute {init: 4.02976, pub: out};
var k5BasicWb: per_minute {init: 2.34e-8, pub: out};
var k_glut1: mg_per_kg_minute {init: 0.2966, pub: out};
var k_glut4: mg_per_kg_minute {init: 31.42, pub: out};
var KmG1: mg_per_kg {init: 132.77, pub: out};
var KmG4: mg_per_kg {init: 70.4032, pub: out};
var kbf: mg_l_per_kg_minute_pmol {init: 0.00312, pub: out};
enddef;-->
<!-- def comp param3 as
var a1: l_per_mol_minute {init: 448251462.712, pub: out};
var a2: l_per_mol_minute {init: 4321891.903, pub: out};
var d1: per_minute {init: 0.7722612342, pub: out};
var d2: per_minute {init: 0.012205776, pub: out};
var K_cr: per_minute {init: 0.001364, pub: out};
var K_ex: per_minute {init: 37.0819, pub: out};
var K_end: per_minute {init: 30.6825, pub: out};
var K_dp: per_minute {init: 0.00095, pub: out};
var K_cat: per_minute {init: 237.5189, pub: out};
var K_m: dimensionless {init: 3.01819, pub: out};
var kfbasal: per_minute {init: 0.49752, pub: out};
var krbasal: per_minute {init: 128042.88, pub: out};
var K4: l_per_mol_minute {init: 1400, pub: out};
var K8: per_minute {init: 0.01, pub: out};
enddef;-->
</model>
