- Author:
- Soroush Safaei <ssaf006@aucklanduni.ac.nz>
- Date:
- 2017-05-30 16:37:27+12:00
- Desc:
-
finishing the diabetes model from Gunnar with standard units
- Permanent Source URI:
- https://models.physiomeproject.org/workspace/483/rawfile/1117ca898eff573b66df394c2e3f4d8e785ff923/SI/Parameters.cellml
<?xml version='1.0'?>
<model name="Parameters" xmlns="http://www.cellml.org/cellml/1.1#" xmlns:cellml="http://www.cellml.org/cellml/1.1#">
<component name="param1">
<!-- V_G: distribution volume of Glucose
V_I: distribution volume of Insulin
k_abs: rate of intestinal absorption
k_gri: rate of grinding
f: fraction of intestinal absorption appears in plasma
k_p1: extrapolated EGP at zero Glucose and Insulin
k_p2: liver Glucose effectiveness
k_p3: amplitude of Insulin action on liver
k_p4: amplitude of portal Insulin action on liver
k_i: delay between Insulin signal and Insulin action
U_ii: Glucose Insulin independent utilisation
p_2U: rate constant of Insulin action on the peripheral Glucose utilisation
K: pancreatic responsivity to Glucose rate of change
alpha: delay between Glucose signal & Insulin secretion
beta: pancreatic responsivity to Glucose
gamma: transfer rate constant between portalvein & liver
BW: body weight
D: ingested Glucose mass-->
<variable initial_value="25e-12" name="I_b" public_interface="out" units="M"/>
<variable initial_value="0.6471" name="m_6" public_interface="out" units="dimensionless"/>
<variable initial_value="0.6" name="HE_b" public_interface="out" units="dimensionless"/>
<variable initial_value="0.9" name="f" public_interface="out" units="dimensionless"/>
<variable initial_value="0.82" name="b" public_interface="out" units="dimensionless"/>
<variable initial_value="0.01" name="d" public_interface="out" units="dimensionless"/>
<variable initial_value="225.59e-6" name="K_m0" public_interface="out" units="dimensionless"/>
<variable initial_value="0.2" name="part" public_interface="out" units="dimensionless"/>
<variable initial_value="78" name="BW" public_interface="out" units="kilogram"/>
<variable initial_value="0.078" name="D" public_interface="out" units="kilogram"/>
<variable initial_value="0.00093" name="k_max" public_interface="out" units="per_s"/>
<variable initial_value="0.00013" name="k_min" public_interface="out" units="per_s"/>
<variable initial_value="0.00095" name="k_abs" public_interface="out" units="per_s"/>
<variable initial_value="0.00093" name="k_gri" public_interface="out" units="per_s"/>
<variable initial_value="45e-9" name="k_p1" public_interface="out" units="per_s"/>
<variable initial_value="0.000035" name="k_p2" public_interface="out" units="per_s"/>
<variable initial_value="0.000132" name="k_i" public_interface="out" units="per_s"/>
<variable initial_value="0.01667e-6" name="U_ii" public_interface="out" units="per_s"/>
<variable initial_value="0.04167e-6" name="V_m0" public_interface="out" units="per_s"/>
<variable initial_value="0.000552" name="p_2U" public_interface="out" units="per_s"/>
<variable initial_value="0.000833" name="alpha" public_interface="out" units="per_s"/>
<variable initial_value="0.008333" name="gamma" public_interface="out" units="per_s"/>
<variable initial_value="0.001083" name="k_1" public_interface="out" units="per_s"/>
<variable initial_value="0.001317" name="k_2" public_interface="out" units="per_s"/>
<variable initial_value="0.00317" name="m_1" public_interface="out" units="per_s"/>
<variable initial_value="0.00807" name="m_2" public_interface="out" units="per_s"/>
<variable initial_value="0.00323" name="m_4" public_interface="out" units="per_s"/>
<variable initial_value="150" name="k_p3" public_interface="out" units="per_M_s"/>
<variable initial_value="783.3" name="V_mX" public_interface="out" units="per_M_s"/>
<variable initial_value="950e-6" name="G_b" public_interface="out" units="kg_per_l"/>
<variable initial_value="1030" name="k_p4" public_interface="out" units="kg_per_mol_s"/>
<variable initial_value="1.824e+12" name="m_5" public_interface="out" units="kg_s_per_mol"/>
<variable initial_value="0.188" name="V_G" public_interface="out" units="l_per_kg"/>
<variable initial_value="0.05" name="V_I" public_interface="out" units="l_per_kg"/>
<variable initial_value="0.03e-12" name="S_b" public_interface="out" units="mol_per_kg_s"/>
<variable initial_value="0.23e-6" name="K" public_interface="out" units="mol_l_per_kg2"/>
<variable initial_value="183.3e-12" name="beta" public_interface="out" units="mol_l_per_kg2_s"/>
</component>
<component name="param2">
<variable initial_value="132.77e-6" name="KmG1" public_interface="out" units="dimensionless"/>
<variable initial_value="70.4032e-6" name="KmG4" public_interface="out" units="dimensionless"/>
<variable initial_value="2374.9773" name="k22" public_interface="out" units="dimensionless"/>
<variable initial_value="0.1199" name="k23" public_interface="out" units="dimensionless"/>
<variable initial_value="0.9431" name="k24" public_interface="out" units="dimensionless"/>
<variable initial_value="0.00016076438" name="k21" public_interface="out" units="per_s"/>
<variable initial_value="10.143067" name="k2b" public_interface="out" units="per_s"/>
<variable initial_value="0.1351983" name="k3f" public_interface="out" units="per_s"/>
<variable initial_value="0.0031583" name="k3b" public_interface="out" units="per_s"/>
<variable initial_value="6414.761467" name="k4f" public_interface="out" units="per_s"/>
<variable initial_value="468.951167" name="k4b" public_interface="out" units="per_s"/>
<variable initial_value="1071.66785" name="k5f" public_interface="out" units="per_s"/>
<variable initial_value="167.541807" name="k5b" public_interface="out" units="per_s"/>
<variable initial_value="268236.6965" name="k6f" public_interface="out" units="per_s"/>
<variable initial_value="1.2962" name="k6b" public_interface="out" units="per_s"/>
<variable initial_value="69.57717" name="k7f" public_interface="out" units="per_s"/>
<variable initial_value="9422.36937" name="k7b" public_interface="out" units="per_s"/>
<variable initial_value="25262.707" name="k8f" public_interface="out" units="per_s"/>
<variable initial_value="5.0125167" name="k8b" public_interface="out" units="per_s"/>
<variable initial_value="1.3567e-09" name="k91" public_interface="out" units="per_s"/>
<variable initial_value="0.0004683" name="k92" public_interface="out" units="per_s"/>
<variable initial_value="0.0671627" name="k9b" public_interface="out" units="per_s"/>
<variable initial_value="0.004943e-6" name="k_glut1" public_interface="out" units="per_s"/>
<variable initial_value="0.52367e-6" name="k_glut4" public_interface="out" units="per_s"/>
<variable initial_value="3.9e-10" name="k5BasicWb" public_interface="out" units="per_s"/>
<variable initial_value="52" name="kbf" public_interface="out" units="per_M_s"/>
</component>
<component name="param3">
<variable initial_value="3.01819" name="K_m" public_interface="out" units="dimensionless"/>
<variable initial_value="0.01287102" name="d1" public_interface="out" units="per_s"/>
<variable initial_value="0.00020343" name="d2" public_interface="out" units="per_s"/>
<variable initial_value="2.273e-05" name="K_cr" public_interface="out" units="per_s"/>
<variable initial_value="0.61803167" name="K_ex" public_interface="out" units="per_s"/>
<variable initial_value="0.511375" name="K_end" public_interface="out" units="per_s"/>
<variable initial_value="1.583e-05" name="K_dp" public_interface="out" units="per_s"/>
<variable initial_value="3.9586483" name="K_cat" public_interface="out" units="per_s"/>
<variable initial_value="0.008292" name="kfbasal" public_interface="out" units="per_s"/>
<variable initial_value="2134.048" name="krbasal" public_interface="out" units="per_s"/>
<variable initial_value="0.000167" name="K8" public_interface="out" units="per_s"/>
<variable initial_value="7470857.7" name="a1" public_interface="out" units="per_M_s"/>
<variable initial_value="72031.532" name="a2" public_interface="out" units="per_M_s"/>
<variable initial_value="23.33" name="K4" public_interface="out" units="per_M_s"/>
</component>
</model>
