- Author:
- Soroush Safaei <ssaf006@aucklanduni.ac.nz>
- Date:
- 2018-07-29 23:30:09+12:00
- Desc:
- modular
- Permanent Source URI:
- https://models.physiomeproject.org/workspace/436/rawfile/a3e40926098096b3269538f412265b538889ec5e/CFTR.cellml
<?xml version='1.0'?>
<model name="BK" xmlns="http://www.cellml.org/cellml/1.1#" xmlns:cellml="http://www.cellml.org/cellml/1.1#">
<component name="CFTR">
<variable name="z_Cl" public_interface="in" units="dimensionless"/>
<variable name="R" public_interface="in" units="J_per_mol_K"/>
<variable name="T" public_interface="in" units="kelvin"/>
<variable name="q_Cl_c" public_interface="in" units="M"/>
<variable name="q_Cl_a" public_interface="in" units="M"/>
<variable name="V_A_Cl" public_interface="out" units="volt"/>
<variable name="V_A_HCO3" public_interface="out" units="volt"/>
<variable name="V_a" public_interface="in" units="volt"/>
<variable name="J_CFTR" public_interface="out" units="umol_per_s"/>
<variable name="J_CFTR1" public_interface="out" units="umol_per_s"/>
<variable name="J_CFTR_HCO3" public_interface="out" units="umol_per_s"/>
<variable name="I_CFTR" public_interface="out" units="uA"/>
<variable name="I_CFTR_HCO3" public_interface="out" units="uA"/>
<variable name="A_Apical" public_interface="in" units="m2"/>
<variable name="F" public_interface="in" units="C_per_mol"/>
<variable initial_value="17" name="G_CFTR" public_interface="out" units="S"/>
<variable name="q_HCO3_c" public_interface="in" units="M"/>
<variable name="q_HCO3_a" public_interface="in" units="M"/>
<variable initial_value="-1" name="z_HCO3" public_interface="out" units="dimensionless"/>
<!-- alpha is multipled by area in order to have a dimensionless unit-->
<variable initial_value="0.1" name="alpha_CFTR" public_interface="out" units="per_m2"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>J_CFTR</ci>
<apply>
<divide/>
<ci>I_CFTR</ci>
<ci>F</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>J_CFTR1</ci>
<apply>
<times/>
<ci>J_CFTR</ci>
<cn cellml:units="dimensionless" type="e-notation">36<sep/>8</cn>
</apply>
</apply>
<apply>
<eq/>
<ci>V_A_Cl</ci>
<apply>
<times/>
<apply>
<divide/>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
<apply>
<times/>
<ci>z_Cl</ci>
<ci>F</ci>
</apply>
</apply>
<apply>
<ln/>
<apply>
<divide/>
<ci>q_Cl_a</ci>
<ci>q_Cl_c</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>I_CFTR</ci>
<apply>
<times/>
<apply>
<minus/>
<cn cellml:units="dimensionless" type="e-notation">1<sep/>6</cn>
</apply>
<ci>G_CFTR</ci>
<ci>alpha_CFTR</ci>
<ci>A_Apical</ci>
<apply>
<minus/>
<ci>V_a</ci>
<ci>V_A_Cl</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>V_A_HCO3</ci>
<apply>
<times/>
<apply>
<divide/>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
<apply>
<times/>
<ci>z_HCO3</ci>
<ci>F</ci>
</apply>
</apply>
<apply>
<ln/>
<apply>
<divide/>
<ci>q_HCO3_a</ci>
<ci>q_HCO3_c</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>I_CFTR_HCO3</ci>
<apply>
<times/>
<cn cellml:units="dimensionless" type="e-notation">0.25<sep/>6</cn>
<ci>G_CFTR</ci>
<ci>alpha_CFTR</ci>
<ci>A_Apical</ci>
<apply>
<minus/>
<ci>V_a</ci>
<ci>V_A_HCO3</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>J_CFTR_HCO3</ci>
<apply>
<divide/>
<ci>I_CFTR_HCO3</ci>
<ci>F</ci>
</apply>
</apply>
</math>
</component>
</model>
