Location: Na+/Glucose Transporter @ 812d5316b74d / Glucose.cellml
- Author:
- Soroush Safaei <ssaf006@aucklanduni.ac.nz>
- Date:
- 2018-07-29 16:39:59+12:00
- Desc:
- clean up the code
- Permanent Source URI:
- https://models.physiomeproject.org/workspace/436/rawfile/812d5316b74d0e4c8c568f7f60f0dd51ed8361b6/Glucose.cellml
<?xml version='1.0'?>
<model name="Nima_2018" xmlns="http://www.cellml.org/cellml/1.1#" xmlns:cellml="http://www.cellml.org/cellml/1.1#" xmlns:xlink="http://www.w3.org/1999/xlink">
<!-- electroneutrality maintained also apical and basolateral concentration considered as constant without any equations
Basolateral concentration are constant and they are same as high glucose DMEM cell culture
No conditon for glucose concentration in the lumen
Output of this model then fitted to experimental data-->
<import xlink:href="Units.cellml">
<units name="per_second" units_ref="per_second"/>
<units name="per_second2" units_ref="per_second2"/>
<units name="volt_per_second" units_ref="volt_per_second"/>
<units name="per_meter" units_ref="per_meter"/>
<units name="per_volt_per_second" units_ref="per_volt_per_second"/>
<units name="per_volt4_per_second" units_ref="per_volt4_per_second"/>
<units name="per_volt3_per_second" units_ref="per_volt3_per_second"/>
<units name="per_volt2_per_second" units_ref="per_volt2_per_second"/>
<units name="per_mol" units_ref="per_mol"/>
<units name="umol" units_ref="umol"/>
<units name="per_umol" units_ref="per_umol"/>
<units name="M" units_ref="M"/>
<units name="per_M" units_ref="per_M"/>
<units name="m2" units_ref="m2"/>
<units name="cm" units_ref="cm"/>
<units name="um2" units_ref="um2"/>
<units name="um" units_ref="um"/>
<units name="um3" units_ref="um3"/>
<units name="m3" units_ref="m3"/>
<units name="mol_per_um2" units_ref="mol_per_um2"/>
<units name="mM" units_ref="mM"/>
<units name="mV" units_ref="mV"/>
<units name="J_per_K_per_mol" units_ref="J_per_K_per_mol"/>
<units name="pA_per_cm2" units_ref="pA_per_cm2"/>
<units name="uA" units_ref="uA"/>
<units name="uA_per_um2" units_ref="uA_per_um2"/>
<units name="uA_per_A" units_ref="uA_per_A"/>
<units name="umol_per_mol" units_ref="umol_per_mol"/>
<units name="C_per_mol" units_ref="C_per_mol"/>
<units name="per_M_per_second" units_ref="per_M_per_second"/>
<units name="per_M2_per_second" units_ref="per_M2_per_second"/>
<units name="per_M4_per_second2" units_ref="per_M4_per_second2"/>
<units name="per_M4_per_second" units_ref="per_M4_per_second"/>
<units name="uM" units_ref="uM"/>
<units name="M2" units_ref="M2"/>
<units name="M3" units_ref="M3"/>
<units name="M3_per_second" units_ref="M3_per_second"/>
<units name="per_M3_per_second5" units_ref="per_M3_per_second5"/>
<units name="M_per_second" units_ref="M_per_second"/>
<units name="cm2" units_ref="cm2"/>
<units name="cm2_per_s" units_ref="cm2_per_s"/>
<units name="mole_per_m2" units_ref="mole_per_m2"/>
<units name="Farad" units_ref="Farad"/>
<units name="uF" units_ref="uF"/>
<units name="uF_per_cm2" units_ref="uF_per_cm2"/>
<units name="umol_per_cm2_per_s" units_ref="umol_per_cm2_per_s"/>
<units name="umol_per_s" units_ref="umol_per_s"/>
<units name="uA_per_cm2" units_ref="uA_per_cm2"/>
<units name="m_per_s" units_ref="m_per_s"/>
<units name="m3_mole_per_litre_per_umol" units_ref="m3_mole_per_litre_per_umol"/>
<units name="litre_umol_per_mol_per_m3" units_ref="litre_umol_per_mol_per_m3"/>
<units name="S" units_ref="S"/>
<units name="S_per_m2" units_ref="S_per_m2"/>
<units name="per_m2" units_ref="per_m2"/>
<units name="cm_per_s" units_ref="cm_per_s"/>
</import>
<component name="Apical_Membrane">
<variable initial_value="0.05" name="q_Gl_a" public_interface="out" units="M"/>
<variable initial_value="0.105" name="q_Na_a" public_interface="out" units="M"/>
<variable initial_value="0.106" name="q_Cl_a" public_interface="out" units="M"/>
<variable initial_value="0.004" name="q_K_a" public_interface="out" units="M"/>
<variable initial_value="-0.046" name="V_a" public_interface="out" units="volt"/>
<variable name="I_D_Na" public_interface="in" units="uA"/>
<variable name="I_D_K" public_interface="in" units="uA"/>
<variable name="I_D_Cl" public_interface="in" units="uA"/>
<variable name="I_D_P_Na" public_interface="in" units="uA"/>
<variable name="I_D_P_K" public_interface="in" units="uA"/>
<variable name="I_D_P_Cl" public_interface="in" units="uA"/>
<variable name="I_NHE3_H" public_interface="in" units="uA"/>
<variable name="I_NHE3_Na" public_interface="in" units="uA"/>
<variable name="I_BK" public_interface="in" units="uA"/>
<variable name="I_ENaC" public_interface="in" units="uA"/>
<variable name="I_Na_SGLT" public_interface="in" units="uA"/>
<variable name="I_CFTR" public_interface="in" units="uA"/>
<variable name="C" public_interface="in" units="uF"/>
<variable name="t" public_interface="in" units="second"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>t</ci>
</bvar>
<ci>V_a</ci>
</apply>
<apply>
<divide/>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<minus/>
<apply>
<plus/>
<ci>I_D_Na</ci>
<ci>I_D_K</ci>
</apply>
<ci>I_D_Cl</ci>
</apply>
<ci>I_Na_SGLT</ci>
</apply>
<ci>I_BK</ci>
</apply>
<ci>I_CFTR</ci>
<ci>I_ENaC</ci>
<ci>I_D_P_Na</ci>
<ci>I_D_P_K</ci>
</apply>
<ci>I_D_P_Cl</ci>
</apply>
<ci>C</ci>
</apply>
</apply>
</math>
</component>
<component name="Epithelial_Cell">
<variable initial_value="0.01" name="q_Gl_c" public_interface="out" units="M"/>
<variable initial_value="0.047" name="q_Na_c" public_interface="out" units="M"/>
<variable initial_value="0.057" name="q_Cl_c" public_interface="out" units="M"/>
<variable initial_value="0.129" name="q_K_c" public_interface="out" units="M"/>
<variable initial_value="6e-5" name="q_Ca_c" public_interface="out" units="M"/>
<variable name="q_H_int" public_interface="out" units="M"/>
<variable name="q_H_ext" public_interface="out" units="M"/>
<variable name="q_H_b" public_interface="out" units="M"/>
<variable initial_value="0.003" name="q_HCO3_a" public_interface="out" units="M"/>
<variable name="q_HCO3_c" public_interface="out" units="M"/>
<variable initial_value="0.041" name="q_HCO3_b" public_interface="out" units="M"/>
<variable name="J_Na_SGLT" public_interface="in" units="umol_per_s"/>
<variable name="J_Gl_SGLT" public_interface="in" units="umol_per_s"/>
<variable name="J_Na_NaK" public_interface="in" units="umol_per_s"/>
<variable name="J_K_NaK" public_interface="in" units="umol_per_s"/>
<variable name="J_NBC_Na" public_interface="in" units="umol_per_s"/>
<variable name="J_NBC_HCO3" public_interface="in" units="umol_per_s"/>
<variable name="J_NHE3_Na" public_interface="in" units="umol_per_s"/>
<variable name="J_NHE3_H" public_interface="in" units="umol_per_s"/>
<variable name="J_D_Na" public_interface="in" units="umol_per_s"/>
<variable name="J_D_Bl_Na" public_interface="in" units="umol_per_s"/>
<variable name="J_GLUT" public_interface="in" units="umol_per_s"/>
<variable name="J_A_GLUT" public_interface="in" units="umol_per_s"/>
<variable name="J_D_K" public_interface="in" units="umol_per_s"/>
<variable name="J_D_Bl_K" public_interface="in" units="umol_per_s"/>
<variable name="J_D_Cl" public_interface="in" units="umol_per_s"/>
<variable name="J_D_Bl_Cl" public_interface="in" units="umol_per_s"/>
<variable name="J_AE1_Cl" public_interface="in" units="umol_per_s"/>
<variable name="J_AE1_HCO3" public_interface="in" units="umol_per_s"/>
<variable name="J_CFTR" public_interface="in" units="umol_per_s"/>
<variable name="J_CFTR_HCO3" public_interface="in" units="umol_per_s"/>
<variable name="J_ENaC" public_interface="in" units="umol_per_s"/>
<variable name="J_NKCC" public_interface="in" units="umol_per_s"/>
<variable name="J_IK" public_interface="in" units="umol_per_s"/>
<variable name="J_BK" public_interface="in" units="umol_per_s"/>
<variable name="J_D_P_Na" public_interface="in" units="umol_per_s"/>
<variable initial_value="7.2" name="pq_H_int" public_interface="out" units="per_second"/>
<variable initial_value="7.3" name="pq_H_ext" public_interface="out" units="per_second"/>
<variable initial_value="7.3" name="pq_H_b" public_interface="out" units="per_second"/>
<variable initial_value="1680000" name="rho" public_interface="out" units="per_meter"/>
<variable name="beta" public_interface="out" units="M"/>
<variable initial_value="6.1" name="p_K" public_interface="out" units="dimensionless"/>
<variable initial_value="40" name="P_CO2" public_interface="out" units="dimensionless"/>
<variable initial_value="1e-5" name="s" public_interface="out" units="dimensionless"/>
<variable initial_value="1" name="theta_1" units="dimensionless"/>
<variable initial_value="1" name="theta_2" units="dimensionless"/>
<variable initial_value="1" name="theta_3" units="dimensionless"/>
<variable initial_value="1" name="theta_4" units="dimensionless"/>
<variable initial_value="1" name="theta_5" units="dimensionless"/>
<variable initial_value="1" name="theta_6" units="dimensionless"/>
<variable initial_value="1" name="theta_7" units="dimensionless"/>
<variable initial_value="1" name="theta_8" units="dimensionless"/>
<variable initial_value="1" name="theta_9" units="dimensionless"/>
<variable initial_value="1" name="theta_10" units="dimensionless"/>
<variable initial_value="1" name="theta_11" units="dimensionless"/>
<variable initial_value="1" name="theta_12" units="dimensionless"/>
<variable initial_value="1" name="theta_13" units="dimensionless"/>
<variable initial_value="1" name="theta_14" units="dimensionless"/>
<variable initial_value="1" name="theta_15" units="dimensionless"/>
<variable initial_value="1" name="theta_16" units="dimensionless"/>
<variable initial_value="1" name="theta_17" units="dimensionless"/>
<variable initial_value="1" name="theta_18" units="dimensionless"/>
<variable initial_value="1" name="theta_19" units="dimensionless"/>
<variable initial_value="1" name="theta_20" units="dimensionless"/>
<variable initial_value="1" name="theta_21" units="dimensionless"/>
<variable initial_value="1" name="theta_22" units="dimensionless"/>
<variable initial_value="1" name="theta_23" units="dimensionless"/>
<variable initial_value="1" name="theta_24" units="dimensionless"/>
<variable initial_value="1" name="theta_25" units="dimensionless"/>
<variable initial_value="1" name="theta_26" units="dimensionless"/>
<variable initial_value="1" name="theta_27" units="dimensionless"/>
<variable name="K_Concentration" public_interface="out" units="M"/>
<variable name="Na_Concentration" public_interface="out" units="M"/>
<variable name="Cl_Concentration" public_interface="out" units="M"/>
<variable name="Total_Gl_Flux_Apical" public_interface="out" units="umol_per_s"/>
<variable name="v_cell" public_interface="in" units="m3"/>
<variable name="A_Apical" public_interface="in" units="m2"/>
<variable name="t" public_interface="in" units="second"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>Total_Gl_Flux_Apical</ci>
<apply>
<plus/>
<ci>J_A_GLUT</ci>
<ci>J_Gl_SGLT</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>Na_Concentration</ci>
<apply>
<plus/>
<apply>
<times/>
<ci>theta_15</ci>
<ci>J_ENaC</ci>
</apply>
<apply>
<times/>
<ci>theta_3</ci>
<ci>J_NHE3_Na</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>K_Concentration</ci>
<apply>
<times/>
<cn cellml:units="dimensionless" type="e-notation">1<sep/>6</cn>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<minus/>
<ci>J_K_NaK</ci>
<ci>J_NKCC</ci>
</apply>
<ci>J_D_K</ci>
<ci>J_D_Bl_K</ci>
</apply>
<apply>
<times/>
<cn cellml:units="dimensionless">0</cn>
<ci>J_IK</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>Cl_Concentration</ci>
<apply>
<times/>
<cn cellml:units="dimensionless" type="e-notation">1<sep/>6</cn>
<apply>
<minus/>
<apply>
<times/>
<ci>theta_11</ci>
<ci>J_CFTR</ci>
</apply>
<apply>
<times/>
<ci>theta_14</ci>
<ci>J_AE1_Cl</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>beta</ci>
<apply>
<times/>
<cn cellml:units="dimensionless">2.3</cn>
<ci>q_HCO3_c</ci>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>t</ci>
</bvar>
<ci>q_Na_c</ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<cn cellml:units="m3_mole_per_litre_per_umol" type="e-notation">1<sep/>-9</cn>
<ci>v_cell</ci>
</apply>
<apply>
<plus/>
<apply>
<minus/>
<apply>
<times/>
<ci>theta_1</ci>
<ci>J_Na_SGLT</ci>
</apply>
<apply>
<times/>
<ci>theta_2</ci>
<ci>J_Na_NaK</ci>
</apply>
</apply>
<apply>
<times/>
<ci>theta_15</ci>
<ci>J_ENaC</ci>
</apply>
<apply>
<times/>
<ci>theta_16</ci>
<ci>J_NKCC</ci>
</apply>
<apply>
<times/>
<ci>theta_19</ci>
<ci>J_NBC_Na</ci>
</apply>
<apply>
<times/>
<ci>theta_4</ci>
<ci>J_D_Na</ci>
</apply>
<apply>
<times/>
<ci>theta_5</ci>
<ci>J_D_Bl_Na</ci>
</apply>
<apply>
<times/>
<ci>theta_3</ci>
<ci>J_NHE3_Na</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>t</ci>
</bvar>
<ci>q_Gl_c</ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<cn cellml:units="m3_mole_per_litre_per_umol" type="e-notation">1<sep/>-9</cn>
<ci>v_cell</ci>
</apply>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<times/>
<ci>theta_26</ci>
<cn cellml:units="dimensionless">1</cn>
<ci>J_A_GLUT</ci>
</apply>
<apply>
<times/>
<ci>theta_6</ci>
<ci>J_Gl_SGLT</ci>
</apply>
</apply>
<apply>
<times/>
<ci>theta_7</ci>
<cn cellml:units="dimensionless">1</cn>
<ci>J_GLUT</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>t</ci>
</bvar>
<ci>q_K_c</ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<cn cellml:units="m3_mole_per_litre_per_umol" type="e-notation">1<sep/>-9</cn>
<ci>v_cell</ci>
</apply>
<apply>
<minus/>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<times/>
<ci>theta_8</ci>
<ci>J_K_NaK</ci>
</apply>
<apply>
<times/>
<ci>theta_17</ci>
<ci>J_NKCC</ci>
</apply>
<apply>
<times/>
<ci>theta_9</ci>
<ci>J_D_K</ci>
</apply>
<apply>
<times/>
<ci>theta_10</ci>
<ci>J_D_Bl_K</ci>
</apply>
</apply>
<apply>
<times/>
<ci>theta_27</ci>
<ci>J_IK</ci>
</apply>
</apply>
<ci>J_BK</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>t</ci>
</bvar>
<ci>q_Cl_c</ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<cn cellml:units="m3_mole_per_litre_per_umol" type="e-notation">1<sep/>-9</cn>
<ci>v_cell</ci>
</apply>
<apply>
<plus/>
<apply>
<times/>
<ci>theta_11</ci>
<apply>
<minus/>
<ci>J_CFTR</ci>
</apply>
</apply>
<apply>
<times/>
<ci>theta_18</ci>
<cn cellml:units="dimensionless">2</cn>
<ci>J_NKCC</ci>
</apply>
<apply>
<times/>
<ci>theta_12</ci>
<ci>J_D_Cl</ci>
</apply>
<apply>
<times/>
<ci>theta_13</ci>
<ci>J_D_Bl_Cl</ci>
</apply>
<apply>
<times/>
<ci>theta_14</ci>
<ci>J_AE1_Cl</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>t</ci>
</bvar>
<ci>pq_H_int</ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<apply>
<times/>
<cn cellml:units="m3_mole_per_litre_per_umol" type="e-notation">1<sep/>-9</cn>
<ci>rho</ci>
</apply>
<apply>
<times/>
<ci>beta</ci>
<ci>A_Apical</ci>
</apply>
</apply>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<times/>
<ci>theta_20</ci>
<ci>J_NBC_HCO3</ci>
</apply>
<apply>
<times/>
<ci>theta_22</ci>
<ci>J_NHE3_H</ci>
</apply>
</apply>
<apply>
<times/>
<ci>theta_25</ci>
<ci>J_AE1_HCO3</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>q_H_int</ci>
<apply>
<power/>
<cn cellml:units="dimensionless">10</cn>
<apply>
<minus/>
<ci>pq_H_int</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>q_HCO3_c</ci>
<apply>
<times/>
<ci>s</ci>
<ci>P_CO2</ci>
<apply>
<power/>
<cn cellml:units="dimensionless">10</cn>
<apply>
<minus/>
<ci>pq_H_int</ci>
<ci>p_K</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>q_H_ext</ci>
<apply>
<power/>
<cn cellml:units="dimensionless">10</cn>
<apply>
<minus/>
<ci>pq_H_ext</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>q_H_b</ci>
<apply>
<power/>
<cn cellml:units="dimensionless">10</cn>
<apply>
<minus/>
<ci>pq_H_b</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="Basolateral_Membrane">
<variable initial_value="0" name="q_Gl_b" public_interface="out" units="M"/>
<variable initial_value="0.155" name="q_Na_b" public_interface="out" units="M"/>
<variable initial_value="0.119" name="q_Cl_b" public_interface="out" units="M"/>
<variable initial_value="0.0054" name="q_K_b" public_interface="out" units="M"/>
<variable name="I_D_Bl_Na" public_interface="in" units="uA"/>
<variable name="I_D_Bl_K" public_interface="in" units="uA"/>
<variable name="I_D_Bl_Cl" public_interface="in" units="uA"/>
<variable name="I_Na_NaK" public_interface="in" units="uA"/>
<variable name="I_K_NaK" public_interface="in" units="uA"/>
<variable name="I_D_P_Na" public_interface="in" units="uA"/>
<variable name="I_D_P_K" public_interface="in" units="uA"/>
<variable name="I_D_P_Cl" public_interface="in" units="uA"/>
<variable name="I_NBC_Na" public_interface="in" units="uA"/>
<variable name="I_NBC_HCO3" public_interface="in" units="uA"/>
<variable name="I_IK" public_interface="in" units="uA"/>
<variable name="C" public_interface="in" units="uF"/>
<variable initial_value="-0.05" name="V_b" public_interface="out" units="volt"/>
<variable name="t" public_interface="in" units="second"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>t</ci>
</bvar>
<ci>V_b</ci>
</apply>
<apply>
<divide/>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<minus/>
<apply>
<minus/>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<minus/>
<apply>
<minus/>
<apply>
<plus/>
<ci>I_D_Bl_Na</ci>
<ci>I_D_Bl_K</ci>
</apply>
<ci>I_D_Bl_Cl</ci>
</apply>
<ci>I_Na_NaK</ci>
</apply>
<ci>I_K_NaK</ci>
<ci>I_NBC_Na</ci>
</apply>
<ci>I_NBC_HCO3</ci>
</apply>
<ci>I_D_P_Na</ci>
</apply>
<ci>I_D_P_K</ci>
</apply>
<ci>I_D_P_Cl</ci>
</apply>
<ci>I_IK</ci>
</apply>
<ci>C</ci>
</apply>
</apply>
</math>
</component>
<component name="Blood">
<variable name="q_Gl_b" public_interface="in" units="M"/>
<variable initial_value="0.012" name="q_Gl_blood" public_interface="out" units="M"/>
<variable name="J_Gl_blood" public_interface="out" units="umol_per_s"/>
<variable initial_value="1e-6" name="K" public_interface="out" units="dimensionless"/>
<variable name="t" public_interface="in" units="second"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>J_Gl_blood</ci>
<apply>
<times/>
<ci>K</ci>
<apply>
<minus/>
<ci>q_Gl_b</ci>
<ci>q_Gl_blood</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>t</ci>
</bvar>
<ci>q_Gl_blood</ci>
</apply>
<cn cellml:units="dimensionless">0</cn>
</apply>
</math>
</component>
<!-- Apical_Membrane-->
<component name="SGLT1">
<variable name="epsilon" public_interface="out" units="per_second"/>
<variable name="lambda" public_interface="out" units="per_M3_per_second5"/>
<variable name="chi" public_interface="out" units="M"/>
<variable name="alpha" public_interface="out" units="M3"/>
<variable name="beta" public_interface="out" units="M2"/>
<variable name="gamma" public_interface="out" units="M3_per_second"/>
<variable name="phi" public_interface="out" units="M_per_second"/>
<variable name="k_12" public_interface="in" units="per_second"/>
<variable name="k_21" public_interface="in" units="per_second"/>
<variable name="k_32" public_interface="in" units="per_second"/>
<variable name="k_34" public_interface="in" units="per_second"/>
<variable name="k_43" public_interface="in" units="per_second"/>
<variable name="k_45" public_interface="in" units="per_second"/>
<variable name="k_54" public_interface="in" units="per_second"/>
<variable name="k_25" public_interface="in" units="per_second"/>
<variable name="k_52" public_interface="in" units="per_second"/>
<variable name="k_56" public_interface="in" units="per_second"/>
<variable name="k_65" public_interface="in" units="per_second"/>
<variable name="k_61" public_interface="in" units="per_second"/>
<variable name="k_16" public_interface="in" units="per_second"/>
<variable name="ks_12" public_interface="in" units="per_M2_per_second"/>
<variable name="k0_23" public_interface="in" units="per_M_per_second"/>
<variable name="F" public_interface="in" units="C_per_mol"/>
<variable name="q_Na_a" public_interface="in" units="M"/>
<variable name="q_Gl_a" public_interface="in" units="M"/>
<variable initial_value="180000000" name="n_SGLT" public_interface="out" units="dimensionless"/>
<variable name="J_Na_SGLT" public_interface="out" units="umol_per_s"/>
<variable name="I_Na_SGLT" public_interface="out" units="uA"/>
<variable name="J_Gl_SGLT" public_interface="out" units="umol_per_s"/>
<variable name="J_GL_SGLT1" public_interface="out" units="umol_per_s"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>lambda</ci>
<apply>
<times/>
<ci>ks_12</ci>
<ci>k0_23</ci>
<apply>
<plus/>
<apply>
<times/>
<ci>k_43</ci>
<ci>k_54</ci>
<ci>k_65</ci>
</apply>
<apply>
<times/>
<ci>k_34</ci>
<ci>k_54</ci>
<ci>k_65</ci>
</apply>
<apply>
<times/>
<ci>k_45</ci>
<ci>k_52</ci>
<ci>k_65</ci>
</apply>
<apply>
<times/>
<ci>k_43</ci>
<ci>k_52</ci>
<ci>k_65</ci>
</apply>
<apply>
<times/>
<ci>k_34</ci>
<ci>k_52</ci>
<ci>k_65</ci>
</apply>
<apply>
<times/>
<ci>k_34</ci>
<ci>k_45</ci>
<ci>k_65</ci>
</apply>
<apply>
<times/>
<ci>k_45</ci>
<ci>k_56</ci>
<ci>k_61</ci>
</apply>
<apply>
<times/>
<ci>k_43</ci>
<ci>k_56</ci>
<ci>k_61</ci>
</apply>
<apply>
<times/>
<ci>k_34</ci>
<ci>k_56</ci>
<ci>k_61</ci>
</apply>
<apply>
<times/>
<ci>k_43</ci>
<ci>k_54</ci>
<ci>k_61</ci>
</apply>
<apply>
<times/>
<ci>k_34</ci>
<ci>k_54</ci>
<ci>k_61</ci>
</apply>
<apply>
<times/>
<ci>k_45</ci>
<ci>k_52</ci>
<ci>k_61</ci>
</apply>
<apply>
<times/>
<ci>k_43</ci>
<ci>k_52</ci>
<ci>k_61</ci>
</apply>
<apply>
<times/>
<ci>k_34</ci>
<ci>k_52</ci>
<ci>k_61</ci>
</apply>
<apply>
<times/>
<ci>k_34</ci>
<ci>k_45</ci>
<ci>k_61</ci>
</apply>
<apply>
<times/>
<ci>k_34</ci>
<ci>k_45</ci>
<ci>k_56</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>chi</ci>
<apply>
<times/>
<apply>
<divide/>
<cn cellml:units="dimensionless">1</cn>
<ci>lambda</ci>
</apply>
<ci>ks_12</ci>
<apply>
<plus/>
<apply>
<times/>
<ci>k_32</ci>
<ci>k_43</ci>
<ci>k_54</ci>
<ci>k_65</ci>
</apply>
<apply>
<times/>
<ci>k_25</ci>
<ci>k_43</ci>
<ci>k_54</ci>
<ci>k_65</ci>
</apply>
<apply>
<times/>
<ci>k_25</ci>
<ci>k_34</ci>
<ci>k_54</ci>
<ci>k_65</ci>
</apply>
<apply>
<times/>
<ci>k_25</ci>
<ci>k_32</ci>
<ci>k_54</ci>
<ci>k_65</ci>
</apply>
<apply>
<times/>
<ci>k_34</ci>
<ci>k_45</ci>
<ci>k_52</ci>
<ci>k_65</ci>
</apply>
<apply>
<times/>
<ci>k_32</ci>
<ci>k_45</ci>
<ci>k_52</ci>
<ci>k_65</ci>
</apply>
<apply>
<times/>
<ci>k_32</ci>
<ci>k_43</ci>
<ci>k_52</ci>
<ci>k_65</ci>
</apply>
<apply>
<times/>
<ci>k_25</ci>
<ci>k_34</ci>
<ci>k_45</ci>
<ci>k_65</ci>
</apply>
<apply>
<times/>
<ci>k_25</ci>
<ci>k_32</ci>
<ci>k_45</ci>
<ci>k_65</ci>
</apply>
<apply>
<times/>
<ci>k_25</ci>
<ci>k_32</ci>
<ci>k_43</ci>
<ci>k_65</ci>
</apply>
<apply>
<times/>
<ci>k_34</ci>
<ci>k_45</ci>
<ci>k_56</ci>
<ci>k_61</ci>
</apply>
<apply>
<times/>
<ci>k_32</ci>
<ci>k_45</ci>
<ci>k_56</ci>
<ci>k_61</ci>
</apply>
<apply>
<times/>
<ci>k_32</ci>
<ci>k_43</ci>
<ci>k_56</ci>
<ci>k_61</ci>
</apply>
<apply>
<times/>
<ci>k_32</ci>
<ci>k_43</ci>
<ci>k_54</ci>
<ci>k_61</ci>
</apply>
<apply>
<times/>
<ci>k_25</ci>
<ci>k_43</ci>
<ci>k_54</ci>
<ci>k_61</ci>
</apply>
<apply>
<times/>
<ci>k_25</ci>
<ci>k_34</ci>
<ci>k_54</ci>
<ci>k_61</ci>
</apply>
<apply>
<times/>
<ci>k_25</ci>
<ci>k_32</ci>
<ci>k_54</ci>
<ci>k_61</ci>
</apply>
<apply>
<times/>
<ci>k_34</ci>
<ci>k_45</ci>
<ci>k_52</ci>
<ci>k_61</ci>
</apply>
<apply>
<times/>
<ci>k_32</ci>
<ci>k_45</ci>
<ci>k_52</ci>
<ci>k_61</ci>
</apply>
<apply>
<times/>
<ci>k_32</ci>
<ci>k_43</ci>
<ci>k_52</ci>
<ci>k_61</ci>
</apply>
<apply>
<times/>
<ci>k_25</ci>
<ci>k_34</ci>
<ci>k_45</ci>
<ci>k_61</ci>
</apply>
<apply>
<times/>
<ci>k_25</ci>
<ci>k_32</ci>
<ci>k_45</ci>
<ci>k_61</ci>
</apply>
<apply>
<times/>
<ci>k_25</ci>
<ci>k_32</ci>
<ci>k_43</ci>
<ci>k_61</ci>
</apply>
<apply>
<times/>
<ci>k_25</ci>
<ci>k_34</ci>
<ci>k_45</ci>
<ci>k_56</ci>
</apply>
<apply>
<times/>
<ci>k_25</ci>
<ci>k_32</ci>
<ci>k_45</ci>
<ci>k_56</ci>
</apply>
<apply>
<times/>
<ci>k_25</ci>
<ci>k_32</ci>
<ci>k_43</ci>
<ci>k_56</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>beta</ci>
<apply>
<times/>
<apply>
<divide/>
<cn cellml:units="dimensionless">1</cn>
<ci>lambda</ci>
</apply>
<ci>k0_23</ci>
<apply>
<plus/>
<apply>
<times/>
<ci>k_16</ci>
<ci>k_43</ci>
<ci>k_54</ci>
<ci>k_65</ci>
</apply>
<apply>
<times/>
<ci>k_16</ci>
<ci>k_34</ci>
<ci>k_54</ci>
<ci>k_65</ci>
</apply>
<apply>
<times/>
<ci>k_16</ci>
<ci>k_45</ci>
<ci>k_52</ci>
<ci>k_65</ci>
</apply>
<apply>
<times/>
<ci>k_16</ci>
<ci>k_43</ci>
<ci>k_52</ci>
<ci>k_65</ci>
</apply>
<apply>
<times/>
<ci>k_16</ci>
<ci>k_34</ci>
<ci>k_52</ci>
<ci>k_65</ci>
</apply>
<apply>
<times/>
<ci>k_16</ci>
<ci>k_34</ci>
<ci>k_45</ci>
<ci>k_65</ci>
</apply>
<apply>
<times/>
<ci>k_34</ci>
<ci>k_45</ci>
<ci>k_56</ci>
<ci>k_61</ci>
</apply>
<apply>
<times/>
<ci>k_16</ci>
<ci>k_34</ci>
<ci>k_45</ci>
<ci>k_56</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>alpha</ci>
<apply>
<times/>
<apply>
<divide/>
<cn cellml:units="dimensionless">1</cn>
<ci>lambda</ci>
</apply>
<apply>
<plus/>
<apply>
<times/>
<ci>k_21</ci>
<ci>k_32</ci>
<ci>k_43</ci>
<ci>k_54</ci>
<ci>k_65</ci>
</apply>
<apply>
<times/>
<ci>k_16</ci>
<ci>k_32</ci>
<ci>k_43</ci>
<ci>k_54</ci>
<ci>k_65</ci>
</apply>
<apply>
<times/>
<ci>k_16</ci>
<ci>k_25</ci>
<ci>k_43</ci>
<ci>k_54</ci>
<ci>k_65</ci>
</apply>
<apply>
<times/>
<ci>k_16</ci>
<ci>k_21</ci>
<ci>k_43</ci>
<ci>k_54</ci>
<ci>k_65</ci>
</apply>
<apply>
<times/>
<ci>k_16</ci>
<ci>k_25</ci>
<ci>k_34</ci>
<ci>k_54</ci>
<ci>k_65</ci>
</apply>
<apply>
<times/>
<ci>k_16</ci>
<ci>k_21</ci>
<ci>k_34</ci>
<ci>k_54</ci>
<ci>k_65</ci>
</apply>
<apply>
<times/>
<ci>k_16</ci>
<ci>k_25</ci>
<ci>k_32</ci>
<ci>k_54</ci>
<ci>k_65</ci>
</apply>
<apply>
<times/>
<ci>k_16</ci>
<ci>k_21</ci>
<ci>k_32</ci>
<ci>k_54</ci>
<ci>k_65</ci>
</apply>
<apply>
<times/>
<ci>k_21</ci>
<ci>k_34</ci>
<ci>k_45</ci>
<ci>k_52</ci>
<ci>k_65</ci>
</apply>
<apply>
<times/>
<ci>k_16</ci>
<ci>k_34</ci>
<ci>k_45</ci>
<ci>k_52</ci>
<ci>k_65</ci>
</apply>
<apply>
<times/>
<ci>k_21</ci>
<ci>k_32</ci>
<ci>k_45</ci>
<ci>k_52</ci>
<ci>k_65</ci>
</apply>
<apply>
<times/>
<ci>k_16</ci>
<ci>k_32</ci>
<ci>k_45</ci>
<ci>k_52</ci>
<ci>k_65</ci>
</apply>
<apply>
<times/>
<ci>k_21</ci>
<ci>k_32</ci>
<ci>k_43</ci>
<ci>k_52</ci>
<ci>k_65</ci>
</apply>
<apply>
<times/>
<ci>k_16</ci>
<ci>k_32</ci>
<ci>k_43</ci>
<ci>k_52</ci>
<ci>k_65</ci>
</apply>
<apply>
<times/>
<ci>k_16</ci>
<ci>k_25</ci>
<ci>k_34</ci>
<ci>k_45</ci>
<ci>k_65</ci>
</apply>
<apply>
<times/>
<ci>k_16</ci>
<ci>k_21</ci>
<ci>k_34</ci>
<ci>k_45</ci>
<ci>k_65</ci>
</apply>
<apply>
<times/>
<ci>k_16</ci>
<ci>k_25</ci>
<ci>k_32</ci>
<ci>k_45</ci>
<ci>k_65</ci>
</apply>
<apply>
<times/>
<ci>k_16</ci>
<ci>k_21</ci>
<ci>k_32</ci>
<ci>k_45</ci>
<ci>k_65</ci>
</apply>
<apply>
<times/>
<ci>k_16</ci>
<ci>k_25</ci>
<ci>k_32</ci>
<ci>k_43</ci>
<ci>k_65</ci>
</apply>
<apply>
<times/>
<ci>k_16</ci>
<ci>k_21</ci>
<ci>k_32</ci>
<ci>k_43</ci>
<ci>k_65</ci>
</apply>
<apply>
<times/>
<ci>k_25</ci>
<ci>k_34</ci>
<ci>k_45</ci>
<ci>k_56</ci>
<ci>k_61</ci>
</apply>
<apply>
<times/>
<ci>k_21</ci>
<ci>k_34</ci>
<ci>k_45</ci>
<ci>k_56</ci>
<ci>k_61</ci>
</apply>
<apply>
<times/>
<ci>k_25</ci>
<ci>k_32</ci>
<ci>k_45</ci>
<ci>k_56</ci>
<ci>k_61</ci>
</apply>
<apply>
<times/>
<ci>k_21</ci>
<ci>k_32</ci>
<ci>k_45</ci>
<ci>k_56</ci>
<ci>k_61</ci>
</apply>
<apply>
<times/>
<ci>k_25</ci>
<ci>k_32</ci>
<ci>k_43</ci>
<ci>k_56</ci>
<ci>k_61</ci>
</apply>
<apply>
<times/>
<ci>k_21</ci>
<ci>k_32</ci>
<ci>k_43</ci>
<ci>k_56</ci>
<ci>k_61</ci>
</apply>
<apply>
<times/>
<ci>k_21</ci>
<ci>k_32</ci>
<ci>k_43</ci>
<ci>k_54</ci>
<ci>k_61</ci>
</apply>
<apply>
<times/>
<ci>k_21</ci>
<ci>k_34</ci>
<ci>k_45</ci>
<ci>k_52</ci>
<ci>k_61</ci>
</apply>
<apply>
<times/>
<ci>k_21</ci>
<ci>k_32</ci>
<ci>k_45</ci>
<ci>k_52</ci>
<ci>k_61</ci>
</apply>
<apply>
<times/>
<ci>k_21</ci>
<ci>k_32</ci>
<ci>k_43</ci>
<ci>k_52</ci>
<ci>k_61</ci>
</apply>
<apply>
<times/>
<ci>k_16</ci>
<ci>k_25</ci>
<ci>k_34</ci>
<ci>k_45</ci>
<ci>k_56</ci>
</apply>
<apply>
<times/>
<ci>k_16</ci>
<ci>k_21</ci>
<ci>k_34</ci>
<ci>k_45</ci>
<ci>k_56</ci>
</apply>
<apply>
<times/>
<ci>k_16</ci>
<ci>k_25</ci>
<ci>k_32</ci>
<ci>k_45</ci>
<ci>k_56</ci>
</apply>
<apply>
<times/>
<ci>k_16</ci>
<ci>k_21</ci>
<ci>k_32</ci>
<ci>k_45</ci>
<ci>k_56</ci>
</apply>
<apply>
<times/>
<ci>k_16</ci>
<ci>k_25</ci>
<ci>k_32</ci>
<ci>k_43</ci>
<ci>k_56</ci>
</apply>
<apply>
<times/>
<ci>k_16</ci>
<ci>k_21</ci>
<ci>k_32</ci>
<ci>k_43</ci>
<ci>k_56</ci>
</apply>
<apply>
<times/>
<ci>k_16</ci>
<ci>k_21</ci>
<ci>k_32</ci>
<ci>k_43</ci>
<ci>k_54</ci>
</apply>
<apply>
<times/>
<ci>k_16</ci>
<ci>k_21</ci>
<ci>k_34</ci>
<ci>k_45</ci>
<ci>k_52</ci>
</apply>
<apply>
<times/>
<ci>k_16</ci>
<ci>k_21</ci>
<ci>k_32</ci>
<ci>k_45</ci>
<ci>k_52</ci>
</apply>
<apply>
<times/>
<ci>k_16</ci>
<ci>k_21</ci>
<ci>k_32</ci>
<ci>k_43</ci>
<ci>k_52</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>gamma</ci>
<apply>
<times/>
<apply>
<divide/>
<cn cellml:units="dimensionless">1</cn>
<ci>lambda</ci>
</apply>
<ci>k_16</ci>
<ci>k_21</ci>
<ci>k_65</ci>
<apply>
<plus/>
<apply>
<times/>
<ci>k_32</ci>
<ci>k_43</ci>
<ci>k_54</ci>
</apply>
<apply>
<times/>
<ci>k_34</ci>
<ci>k_45</ci>
<ci>k_52</ci>
</apply>
<apply>
<times/>
<ci>k_32</ci>
<ci>k_45</ci>
<ci>k_52</ci>
</apply>
<apply>
<times/>
<ci>k_32</ci>
<ci>k_43</ci>
<ci>k_52</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>phi</ci>
<apply>
<times/>
<apply>
<divide/>
<apply>
<minus/>
<cn cellml:units="dimensionless">1</cn>
</apply>
<ci>lambda</ci>
</apply>
<ci>ks_12</ci>
<ci>k_56</ci>
<ci>k_61</ci>
<apply>
<plus/>
<apply>
<times/>
<ci>k_25</ci>
<ci>k_34</ci>
<ci>k_45</ci>
</apply>
<apply>
<times/>
<ci>k_25</ci>
<ci>k_32</ci>
<ci>k_45</ci>
</apply>
<apply>
<times/>
<ci>k_25</ci>
<ci>k_32</ci>
<ci>k_43</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>epsilon</ci>
<apply>
<times/>
<apply>
<divide/>
<apply>
<minus/>
<cn cellml:units="dimensionless">1</cn>
</apply>
<ci>lambda</ci>
</apply>
<ci>ks_12</ci>
<ci>k0_23</ci>
<ci>k_34</ci>
<ci>k_45</ci>
<ci>k_56</ci>
<ci>k_61</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>J_Na_SGLT</ci>
<apply>
<divide/>
<apply>
<times/>
<apply>
<divide/>
<apply>
<times/>
<apply>
<minus/>
<cn cellml:units="dimensionless">2</cn>
</apply>
<ci>n_SGLT</ci>
</apply>
<cn cellml:units="per_umol" type="e-notation">6.023<sep/>17</cn>
</apply>
<apply>
<plus/>
<apply>
<times/>
<ci>epsilon</ci>
<apply>
<power/>
<ci>q_Na_a</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
<ci>q_Gl_a</ci>
</apply>
<apply>
<times/>
<ci>phi</ci>
<apply>
<power/>
<ci>q_Na_a</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
<ci>gamma</ci>
</apply>
</apply>
<apply>
<plus/>
<ci>alpha</ci>
<apply>
<times/>
<ci>beta</ci>
<ci>q_Gl_a</ci>
</apply>
<apply>
<times/>
<ci>chi</ci>
<apply>
<power/>
<ci>q_Na_a</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
<apply>
<times/>
<apply>
<power/>
<ci>q_Na_a</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
<ci>q_Gl_a</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>I_Na_SGLT</ci>
<apply>
<times/>
<ci>J_Na_SGLT</ci>
<ci>F</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>J_Gl_SGLT</ci>
<apply>
<times/>
<apply>
<divide/>
<cn cellml:units="dimensionless">1</cn>
<cn cellml:units="dimensionless">2</cn>
</apply>
<ci>J_Na_SGLT</ci>
</apply>
</apply>
<!--to change the unit to picomol/hour-->
<apply>
<eq/>
<ci>J_GL_SGLT1</ci>
<apply>
<times/>
<ci>J_Gl_SGLT</ci>
<cn cellml:units="dimensionless" type="e-notation">36<sep/>8</cn>
</apply>
</apply>
</math>
</component>
<component name="GLUT2_Apical">
<variable initial_value="10" name="K_12" public_interface="out" units="per_M_per_second"/>
<variable initial_value="12.6" name="K_21" public_interface="out" units="per_second"/>
<variable initial_value="500" name="K_23" public_interface="out" units="per_second"/>
<variable initial_value="60" name="K_32" public_interface="out" units="per_second"/>
<variable initial_value="12.6" name="K_34" public_interface="out" units="per_second"/>
<variable initial_value="1" name="K_43" public_interface="out" units="per_M_per_second"/>
<variable initial_value="0.8" name="K_41" public_interface="out" units="per_second"/>
<variable initial_value="12" name="K_14" public_interface="out" units="per_second"/>
<variable name="q_Gl_c" public_interface="in" units="M"/>
<variable name="q_Gl_a" public_interface="in" units="M"/>
<variable name="K_S" public_interface="out" units="M"/>
<variable name="J_A_GLUT" public_interface="out" units="umol_per_s"/>
<variable name="C_tot" public_interface="out" units="mole"/>
<variable initial_value="90000000" name="n_GLUT" public_interface="out" units="dimensionless"/>
<variable name="D" public_interface="out" units="per_second"/>
<variable name="J_A_GLUT1" public_interface="out" units="umol_per_s"/>
<variable name="v_cell" public_interface="in" units="m3"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>C_tot</ci>
<apply>
<divide/>
<ci>n_GLUT</ci>
<cn cellml:units="per_mole" type="e-notation">6.022<sep/>23</cn>
</apply>
</apply>
<apply>
<eq/>
<ci>K_S</ci>
<apply>
<divide/>
<ci>K_21</ci>
<ci>K_12</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>J_A_GLUT</ci>
<apply>
<times/>
<apply>
<divide/>
<apply>
<times/>
<cn cellml:units="dimensionless" type="e-notation">1<sep/>6</cn>
<ci>C_tot</ci>
</apply>
<ci>D</ci>
</apply>
<apply>
<minus/>
<apply>
<divide/>
<apply>
<times/>
<ci>K_23</ci>
<ci>K_41</ci>
<ci>q_Gl_a</ci>
</apply>
<ci>K_S</ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>K_32</ci>
<ci>K_14</ci>
<ci>q_Gl_c</ci>
</apply>
<ci>K_S</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>J_A_GLUT1</ci>
<apply>
<times/>
<ci>J_A_GLUT</ci>
<cn cellml:units="dimensionless" type="e-notation">36<sep/>8</cn>
</apply>
</apply>
<apply>
<eq/>
<ci>D</ci>
<apply>
<plus/>
<apply>
<times/>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>q_Gl_a</ci>
<ci>K_S</ci>
</apply>
</apply>
<apply>
<plus/>
<apply>
<divide/>
<apply>
<times/>
<ci>K_32</ci>
<ci>q_Gl_c</ci>
</apply>
<ci>K_S</ci>
</apply>
<ci>K_41</ci>
</apply>
</apply>
<apply>
<times/>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>q_Gl_c</ci>
<ci>K_S</ci>
</apply>
</apply>
<apply>
<plus/>
<apply>
<divide/>
<apply>
<times/>
<ci>K_23</ci>
<ci>q_Gl_a</ci>
</apply>
<ci>K_S</ci>
</apply>
<ci>K_14</ci>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="NHE3">
<variable name="A_Apical" public_interface="in" units="m2"/>
<variable name="v_cell" public_interface="in" units="m3"/>
<variable name="q_Na_a" public_interface="in" units="M"/>
<variable name="q_Na_c" public_interface="in" units="M"/>
<variable name="q_H_ext" public_interface="in" units="M"/>
<variable name="q_H_int" public_interface="in" units="M"/>
<variable initial_value="0" name="NH4_ext" public_interface="out" units="M"/>
<variable initial_value="0" name="NH4_int" public_interface="out" units="M"/>
<variable name="J_NHE3_Na" public_interface="out" units="umol_per_s"/>
<variable name="J_NHE3_H1" public_interface="out" units="umol_per_s"/>
<variable name="J_NHE3_H" public_interface="out" units="umol_per_s"/>
<variable name="J_NHE3_NH4" public_interface="out" units="umol_per_s"/>
<variable name="J_NHE3_Na_Max" public_interface="out" units="umol_per_s"/>
<variable name="I_NHE3_H" public_interface="out" units="uA"/>
<variable name="I_NHE3_Na" public_interface="out" units="uA"/>
<variable initial_value="0.002" name="x_T" units="M"/>
<variable name="sigma" units="per_second"/>
<variable name="P_Na" units="per_second"/>
<variable name="P_H" units="per_second"/>
<variable name="P_NH4" units="per_second"/>
<variable initial_value="16" name="P0_Na" units="per_second"/>
<variable initial_value="4.8" name="P0_H" units="per_second"/>
<variable initial_value="16" name="P0_NH4" units="per_second"/>
<variable initial_value="0.03" name="K_Na" units="M"/>
<variable initial_value="7.2e-8" name="K_H" units="M"/>
<variable initial_value="0.027" name="K_NH4" units="M"/>
<variable initial_value="1e-9" name="K_I" units="M"/>
<variable initial_value="0" name="f_m" units="dimensionless"/>
<variable initial_value="2" name="f_M" units="dimensionless"/>
<variable name="alpha_ext_Na" units="dimensionless"/>
<variable name="alpha_int_Na" units="dimensionless"/>
<variable name="beta_ext_H" units="dimensionless"/>
<variable name="beta_int_H" units="dimensionless"/>
<variable name="gamma_ext_NH4" units="dimensionless"/>
<variable name="gamma_int_NH4" units="dimensionless"/>
<variable name="F" public_interface="in" units="C_per_mol"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>alpha_ext_Na</ci>
<apply>
<divide/>
<ci>q_Na_a</ci>
<ci>K_Na</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>alpha_int_Na</ci>
<apply>
<divide/>
<ci>q_Na_c</ci>
<ci>K_Na</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>beta_ext_H</ci>
<apply>
<divide/>
<ci>q_H_ext</ci>
<ci>K_H</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>beta_int_H</ci>
<apply>
<divide/>
<ci>q_H_int</ci>
<ci>K_H</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>gamma_ext_NH4</ci>
<apply>
<divide/>
<ci>NH4_ext</ci>
<ci>K_NH4</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>gamma_int_NH4</ci>
<apply>
<divide/>
<ci>NH4_int</ci>
<ci>K_NH4</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>P_Na</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>P0_Na</ci>
<apply>
<plus/>
<apply>
<times/>
<ci>f_M</ci>
<ci>q_H_int</ci>
</apply>
<apply>
<times/>
<ci>f_m</ci>
<ci>K_I</ci>
</apply>
</apply>
</apply>
<apply>
<plus/>
<ci>q_H_int</ci>
<ci>K_I</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>P_H</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>P0_H</ci>
<apply>
<plus/>
<apply>
<times/>
<ci>f_M</ci>
<ci>q_H_int</ci>
</apply>
<apply>
<times/>
<ci>f_m</ci>
<ci>K_I</ci>
</apply>
</apply>
</apply>
<apply>
<plus/>
<ci>q_H_int</ci>
<ci>K_I</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>P_NH4</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>P0_NH4</ci>
<apply>
<plus/>
<apply>
<times/>
<ci>f_M</ci>
<ci>q_H_int</ci>
</apply>
<apply>
<times/>
<ci>f_m</ci>
<ci>K_I</ci>
</apply>
</apply>
</apply>
<apply>
<plus/>
<ci>q_H_int</ci>
<ci>K_I</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>sigma</ci>
<apply>
<plus/>
<apply>
<times/>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<ci>alpha_ext_Na</ci>
<ci>beta_ext_H</ci>
<ci>gamma_ext_NH4</ci>
</apply>
<apply>
<plus/>
<apply>
<times/>
<ci>P_Na</ci>
<ci>alpha_int_Na</ci>
</apply>
<apply>
<times/>
<ci>P_H</ci>
<ci>beta_int_H</ci>
</apply>
<apply>
<times/>
<ci>P_NH4</ci>
<ci>gamma_int_NH4</ci>
</apply>
</apply>
</apply>
<apply>
<times/>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<ci>alpha_int_Na</ci>
<ci>beta_int_H</ci>
<ci>gamma_int_NH4</ci>
</apply>
<apply>
<plus/>
<apply>
<times/>
<ci>P_Na</ci>
<ci>alpha_ext_Na</ci>
</apply>
<apply>
<times/>
<ci>P_H</ci>
<ci>beta_ext_H</ci>
</apply>
<apply>
<times/>
<ci>P_NH4</ci>
<ci>gamma_ext_NH4</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>J_NHE3_Na</ci>
<apply>
<times/>
<apply>
<divide/>
<apply>
<times/>
<apply>
<minus/>
<cn cellml:units="dimensionless" type="e-notation">1<sep/>9</cn>
</apply>
<ci>v_cell</ci>
<ci>x_T</ci>
</apply>
<ci>sigma</ci>
</apply>
<apply>
<plus/>
<apply>
<times/>
<ci>P_Na</ci>
<ci>P_H</ci>
<apply>
<minus/>
<apply>
<times/>
<ci>alpha_int_Na</ci>
<ci>beta_ext_H</ci>
</apply>
<apply>
<times/>
<ci>alpha_ext_Na</ci>
<ci>beta_int_H</ci>
</apply>
</apply>
</apply>
<apply>
<times/>
<ci>P_Na</ci>
<ci>P_NH4</ci>
<apply>
<minus/>
<apply>
<times/>
<ci>alpha_int_Na</ci>
<ci>gamma_ext_NH4</ci>
</apply>
<apply>
<times/>
<ci>alpha_ext_Na</ci>
<ci>gamma_int_NH4</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>J_NHE3_H</ci>
<apply>
<times/>
<apply>
<divide/>
<apply>
<times/>
<cn cellml:units="dimensionless" type="e-notation">1<sep/>9</cn>
<ci>v_cell</ci>
<ci>x_T</ci>
</apply>
<ci>sigma</ci>
</apply>
<apply>
<plus/>
<apply>
<times/>
<ci>P_Na</ci>
<ci>P_H</ci>
<apply>
<minus/>
<apply>
<times/>
<ci>alpha_ext_Na</ci>
<ci>beta_int_H</ci>
</apply>
<apply>
<times/>
<ci>alpha_int_Na</ci>
<ci>beta_ext_H</ci>
</apply>
</apply>
</apply>
<apply>
<times/>
<ci>P_H</ci>
<ci>P_NH4</ci>
<apply>
<minus/>
<apply>
<times/>
<ci>beta_int_H</ci>
<ci>gamma_ext_NH4</ci>
</apply>
<apply>
<times/>
<ci>beta_ext_H</ci>
<ci>gamma_int_NH4</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>J_NHE3_H1</ci>
<apply>
<times/>
<ci>J_NHE3_H</ci>
<cn cellml:units="dimensionless" type="e-notation">36<sep/>8</cn>
</apply>
</apply>
<apply>
<eq/>
<ci>J_NHE3_NH4</ci>
<apply>
<times/>
<apply>
<divide/>
<ci>x_T</ci>
<ci>sigma</ci>
</apply>
<apply>
<plus/>
<apply>
<times/>
<ci>P_Na</ci>
<ci>P_NH4</ci>
<apply>
<minus/>
<apply>
<times/>
<ci>alpha_ext_Na</ci>
<ci>gamma_int_NH4</ci>
</apply>
<apply>
<times/>
<ci>alpha_int_Na</ci>
<ci>gamma_ext_NH4</ci>
</apply>
</apply>
</apply>
<apply>
<times/>
<ci>P_H</ci>
<ci>P_NH4</ci>
<apply>
<minus/>
<apply>
<times/>
<ci>beta_ext_H</ci>
<ci>gamma_int_NH4</ci>
</apply>
<apply>
<times/>
<ci>gamma_ext_NH4</ci>
<ci>beta_int_H</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>J_NHE3_Na_Max</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>x_T</ci>
<ci>P_Na</ci>
<ci>P_H</ci>
</apply>
<apply>
<plus/>
<ci>P_Na</ci>
<ci>P_H</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>I_NHE3_H</ci>
<apply>
<times/>
<ci>J_NHE3_H</ci>
<ci>F</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>I_NHE3_Na</ci>
<apply>
<times/>
<ci>J_NHE3_Na</ci>
<ci>F</ci>
</apply>
</apply>
</math>
</component>
<component name="AE1">
<variable name="A_Apical" public_interface="in" units="m2"/>
<variable name="v_cell" public_interface="in" units="m3"/>
<variable name="q_HCO3_c" public_interface="in" units="M"/>
<variable name="q_HCO3_a" public_interface="in" units="M"/>
<variable name="q_Cl_c" public_interface="in" units="M"/>
<variable name="q_Cl_a" public_interface="in" units="M"/>
<variable name="J_AE1_HCO3" public_interface="out" units="umol_per_s"/>
<variable name="J_AE1_Cl" public_interface="out" units="umol_per_s"/>
<variable name="I_AE1_HCO3" public_interface="out" units="uA"/>
<variable name="I_AE1_Cl" public_interface="out" units="uA"/>
<variable name="J_q_HCO3_cnflux" public_interface="out" units="umol_per_s"/>
<variable name="J_q_Cl_cnflux" public_interface="out" units="umol_per_s"/>
<variable initial_value="0.198" name="K_q_HCO3_a" units="M"/>
<variable initial_value="0.198" name="K_q_HCO3_c" units="M"/>
<variable initial_value="0.05" name="K_q_Cl_b" units="M"/>
<variable initial_value="0.05" name="K_q_Cl_c" units="M"/>
<variable initial_value="1247" name="P_q_HCO3_a" units="per_second"/>
<variable initial_value="135" name="P_q_HCO3_c" units="per_second"/>
<variable initial_value="562" name="P_q_Cl_b" units="per_second"/>
<variable initial_value="61" name="P_q_Cl_c" units="per_second"/>
<variable name="beta_ext" units="dimensionless"/>
<variable name="beta_int" units="dimensionless"/>
<variable name="gamma_ext" units="dimensionless"/>
<variable name="gamma_int" units="dimensionless"/>
<variable name="sigma" units="per_second"/>
<variable initial_value="0.001" name="x_Tmax" units="M"/>
<variable initial_value="0.172" name="K_I" units="M"/>
<variable name="x_T" units="M"/>
<variable name="x_ext" units="M"/>
<variable name="x_int" units="M"/>
<variable name="Jo_bm" units="umol_per_s"/>
<variable name="Ji_bm" units="umol_per_s"/>
<variable name="Js_bm" units="umol_per_s"/>
<variable name="Jo_cm" units="umol_per_s"/>
<variable name="Ji_cm" units="umol_per_s"/>
<variable name="Js_cm" units="umol_per_s"/>
<variable name="F" public_interface="in" units="C_per_mol"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>x_T</ci>
<apply>
<divide/>
<ci>x_Tmax</ci>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>q_HCO3_c</ci>
<ci>K_I</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>beta_ext</ci>
<apply>
<divide/>
<ci>q_HCO3_a</ci>
<ci>K_q_HCO3_a</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>beta_int</ci>
<apply>
<divide/>
<ci>q_HCO3_c</ci>
<ci>K_q_HCO3_c</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>gamma_ext</ci>
<apply>
<divide/>
<ci>q_Cl_a</ci>
<ci>K_q_Cl_b</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>gamma_int</ci>
<apply>
<divide/>
<ci>q_Cl_c</ci>
<ci>K_q_Cl_c</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>sigma</ci>
<apply>
<plus/>
<apply>
<times/>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<ci>beta_ext</ci>
<ci>gamma_ext</ci>
</apply>
<apply>
<plus/>
<apply>
<times/>
<ci>P_q_HCO3_c</ci>
<ci>beta_int</ci>
</apply>
<apply>
<times/>
<ci>P_q_Cl_c</ci>
<ci>gamma_int</ci>
</apply>
</apply>
</apply>
<apply>
<times/>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<ci>beta_int</ci>
<ci>gamma_int</ci>
</apply>
<apply>
<plus/>
<apply>
<times/>
<ci>P_q_HCO3_a</ci>
<ci>beta_ext</ci>
</apply>
<apply>
<times/>
<ci>P_q_Cl_b</ci>
<ci>gamma_ext</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>J_AE1_HCO3</ci>
<apply>
<times/>
<apply>
<divide/>
<apply>
<times/>
<cn cellml:units="dimensionless" type="e-notation">1<sep/>9</cn>
<ci>v_cell</ci>
<ci>x_Tmax</ci>
</apply>
<ci>sigma</ci>
</apply>
<apply>
<minus/>
<apply>
<times/>
<ci>P_q_HCO3_c</ci>
<ci>beta_int</ci>
<ci>P_q_Cl_b</ci>
<ci>gamma_ext</ci>
</apply>
<apply>
<times/>
<ci>P_q_HCO3_a</ci>
<ci>beta_ext</ci>
<ci>P_q_Cl_c</ci>
<ci>gamma_int</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>J_AE1_Cl</ci>
<ci>J_AE1_HCO3</ci>
</apply>
<apply>
<eq/>
<ci>I_AE1_HCO3</ci>
<apply>
<times/>
<ci>J_AE1_HCO3</ci>
<ci>F</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>I_AE1_Cl</ci>
<apply>
<times/>
<ci>J_AE1_Cl</ci>
<ci>F</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>x_ext</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>x_T</ci>
<apply>
<plus/>
<apply>
<times/>
<ci>P_q_HCO3_c</ci>
<ci>beta_int</ci>
</apply>
<apply>
<times/>
<ci>P_q_Cl_c</ci>
<ci>gamma_int</ci>
</apply>
</apply>
</apply>
<ci>sigma</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>x_int</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>x_T</ci>
<apply>
<plus/>
<apply>
<times/>
<ci>P_q_HCO3_a</ci>
<ci>beta_ext</ci>
</apply>
<apply>
<times/>
<ci>P_q_Cl_b</ci>
<ci>gamma_ext</ci>
</apply>
</apply>
</apply>
<ci>sigma</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>J_q_HCO3_cnflux</ci>
<apply>
<times/>
<apply>
<divide/>
<ci>x_T</ci>
<ci>sigma</ci>
</apply>
<ci>P_q_HCO3_a</ci>
<ci>beta_ext</ci>
<apply>
<plus/>
<apply>
<times/>
<ci>P_q_HCO3_c</ci>
<ci>beta_int</ci>
</apply>
<apply>
<times/>
<ci>P_q_Cl_c</ci>
<ci>gamma_int</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>J_q_Cl_cnflux</ci>
<apply>
<times/>
<apply>
<divide/>
<ci>x_T</ci>
<ci>sigma</ci>
</apply>
<ci>P_q_Cl_b</ci>
<ci>gamma_ext</ci>
<apply>
<plus/>
<apply>
<times/>
<ci>P_q_HCO3_c</ci>
<ci>beta_int</ci>
</apply>
<apply>
<times/>
<ci>P_q_Cl_c</ci>
<ci>gamma_int</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>Jo_bm</ci>
<apply>
<power/>
<apply>
<times/>
<apply>
<divide/>
<cn cellml:units="dimensionless">1</cn>
<ci>x_T</ci>
</apply>
<apply>
<plus/>
<apply>
<divide/>
<cn cellml:units="dimensionless">1</cn>
<ci>P_q_HCO3_a</ci>
</apply>
<apply>
<divide/>
<cn cellml:units="dimensionless">1</cn>
<ci>P_q_HCO3_c</ci>
</apply>
<apply>
<divide/>
<ci>K_q_HCO3_c</ci>
<apply>
<times/>
<ci>P_q_HCO3_c</ci>
<ci>q_HCO3_c</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<minus/>
<cn cellml:units="dimensionless">1</cn>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>Ji_bm</ci>
<apply>
<power/>
<apply>
<times/>
<apply>
<divide/>
<cn cellml:units="dimensionless">1</cn>
<ci>x_T</ci>
</apply>
<apply>
<plus/>
<apply>
<divide/>
<cn cellml:units="dimensionless">1</cn>
<ci>P_q_HCO3_a</ci>
</apply>
<apply>
<divide/>
<cn cellml:units="dimensionless">1</cn>
<ci>P_q_HCO3_c</ci>
</apply>
<apply>
<divide/>
<ci>K_q_HCO3_a</ci>
<apply>
<times/>
<ci>P_q_HCO3_a</ci>
<ci>q_HCO3_a</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<minus/>
<cn cellml:units="dimensionless">1</cn>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>Js_bm</ci>
<apply>
<power/>
<apply>
<times/>
<apply>
<divide/>
<cn cellml:units="dimensionless">1</cn>
<ci>x_T</ci>
</apply>
<apply>
<plus/>
<apply>
<divide/>
<cn cellml:units="dimensionless">1</cn>
<ci>P_q_HCO3_a</ci>
</apply>
<apply>
<divide/>
<cn cellml:units="dimensionless">1</cn>
<ci>P_q_HCO3_c</ci>
</apply>
</apply>
</apply>
<apply>
<minus/>
<cn cellml:units="dimensionless">1</cn>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>Jo_cm</ci>
<apply>
<power/>
<apply>
<times/>
<apply>
<divide/>
<cn cellml:units="dimensionless">1</cn>
<ci>x_T</ci>
</apply>
<apply>
<plus/>
<apply>
<divide/>
<cn cellml:units="dimensionless">1</cn>
<ci>P_q_Cl_b</ci>
</apply>
<apply>
<divide/>
<cn cellml:units="dimensionless">1</cn>
<ci>P_q_Cl_c</ci>
</apply>
<apply>
<divide/>
<ci>K_q_Cl_c</ci>
<apply>
<times/>
<ci>P_q_Cl_c</ci>
<ci>q_Cl_c</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<minus/>
<cn cellml:units="dimensionless">1</cn>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>Ji_cm</ci>
<apply>
<power/>
<apply>
<times/>
<apply>
<divide/>
<cn cellml:units="dimensionless">1</cn>
<ci>x_T</ci>
</apply>
<apply>
<plus/>
<apply>
<divide/>
<cn cellml:units="dimensionless">1</cn>
<ci>P_q_Cl_b</ci>
</apply>
<apply>
<divide/>
<cn cellml:units="dimensionless">1</cn>
<ci>P_q_Cl_c</ci>
</apply>
<apply>
<divide/>
<ci>K_q_Cl_b</ci>
<apply>
<times/>
<ci>P_q_Cl_b</ci>
<ci>q_Cl_a</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<minus/>
<cn cellml:units="dimensionless">1</cn>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>Js_cm</ci>
<apply>
<power/>
<apply>
<times/>
<apply>
<divide/>
<cn cellml:units="dimensionless">1</cn>
<ci>x_T</ci>
</apply>
<apply>
<plus/>
<apply>
<divide/>
<cn cellml:units="dimensionless">1</cn>
<ci>P_q_Cl_b</ci>
</apply>
<apply>
<divide/>
<cn cellml:units="dimensionless">1</cn>
<ci>P_q_Cl_c</ci>
</apply>
</apply>
</apply>
<apply>
<minus/>
<cn cellml:units="dimensionless">1</cn>
</apply>
</apply>
</apply>
</math>
</component>
<component name="CFTR">
<variable name="z_Cl" public_interface="in" units="dimensionless"/>
<variable name="R" public_interface="in" units="J_per_K_per_mol"/>
<variable name="T" public_interface="in" units="kelvin"/>
<variable name="q_Cl_c" public_interface="in" units="M"/>
<variable name="q_Cl_a" public_interface="in" units="M"/>
<variable name="V_A_Cl" public_interface="out" units="volt"/>
<variable name="V_A_HCO3" public_interface="out" units="volt"/>
<variable name="V_a" public_interface="in" units="volt"/>
<variable name="J_CFTR" public_interface="out" units="umol_per_s"/>
<variable name="J_CFTR1" public_interface="out" units="umol_per_s"/>
<variable name="J_CFTR_HCO3" public_interface="out" units="umol_per_s"/>
<variable name="I_CFTR" public_interface="out" units="uA"/>
<variable name="I_CFTR_HCO3" public_interface="out" units="uA"/>
<variable name="A_Apical" public_interface="in" units="m2"/>
<variable name="F" public_interface="in" units="C_per_mol"/>
<variable initial_value="17" name="G_CFTR" public_interface="out" units="S"/>
<variable name="q_HCO3_c" public_interface="in" units="M"/>
<variable name="q_HCO3_a" public_interface="in" units="M"/>
<variable initial_value="-1" name="z_HCO3" public_interface="out" units="dimensionless"/>
<!-- alpha is multipled by area in order to have a dimensionless unit-->
<variable initial_value="0.1" name="alpha_CFTR" public_interface="out" units="per_m2"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>J_CFTR</ci>
<apply>
<divide/>
<ci>I_CFTR</ci>
<ci>F</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>J_CFTR1</ci>
<apply>
<times/>
<ci>J_CFTR</ci>
<cn cellml:units="dimensionless" type="e-notation">36<sep/>8</cn>
</apply>
</apply>
<apply>
<eq/>
<ci>V_A_Cl</ci>
<apply>
<times/>
<apply>
<divide/>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
<apply>
<times/>
<ci>z_Cl</ci>
<ci>F</ci>
</apply>
</apply>
<apply>
<ln/>
<apply>
<divide/>
<ci>q_Cl_a</ci>
<ci>q_Cl_c</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>I_CFTR</ci>
<apply>
<times/>
<apply>
<minus/>
<cn cellml:units="dimensionless" type="e-notation">1<sep/>6</cn>
</apply>
<ci>G_CFTR</ci>
<ci>alpha_CFTR</ci>
<ci>A_Apical</ci>
<apply>
<minus/>
<ci>V_a</ci>
<ci>V_A_Cl</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>V_A_HCO3</ci>
<apply>
<times/>
<apply>
<divide/>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
<apply>
<times/>
<ci>z_HCO3</ci>
<ci>F</ci>
</apply>
</apply>
<apply>
<ln/>
<apply>
<divide/>
<ci>q_HCO3_a</ci>
<ci>q_HCO3_c</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>I_CFTR_HCO3</ci>
<apply>
<times/>
<cn cellml:units="dimensionless" type="e-notation">0.25<sep/>6</cn>
<ci>G_CFTR</ci>
<ci>alpha_CFTR</ci>
<ci>A_Apical</ci>
<apply>
<minus/>
<ci>V_a</ci>
<ci>V_A_HCO3</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>J_CFTR_HCO3</ci>
<apply>
<divide/>
<ci>I_CFTR_HCO3</ci>
<ci>F</ci>
</apply>
</apply>
</math>
</component>
<component name="ENaC">
<variable name="z_Na" public_interface="in" units="dimensionless"/>
<variable name="R" public_interface="in" units="J_per_K_per_mol"/>
<variable name="T" public_interface="in" units="kelvin"/>
<variable name="q_Na_c" public_interface="in" units="M"/>
<variable name="q_Na_a" public_interface="in" units="M"/>
<variable name="V_A_Na" public_interface="out" units="volt"/>
<variable name="V_a" public_interface="in" units="volt"/>
<variable name="J_ENaC" public_interface="out" units="umol_per_s"/>
<variable name="J_ENaC1" public_interface="out" units="umol_per_s"/>
<variable name="I_ENaC" public_interface="out" units="uA"/>
<variable name="A_Apical" public_interface="in" units="m2"/>
<variable name="F" public_interface="in" units="C_per_mol"/>
<variable initial_value="9" name="G_ENaC" public_interface="out" units="S"/>
<!-- alpha is not multipled by area in order to have a dimensionless unit, so the unit is actually 1/m2, it's necessary to the same for CFTR as well-->
<variable initial_value="0.1" name="alpha_ENaC" public_interface="out" units="per_m2"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>J_ENaC</ci>
<apply>
<divide/>
<ci>I_ENaC</ci>
<ci>F</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>J_ENaC1</ci>
<apply>
<times/>
<ci>J_ENaC</ci>
<cn cellml:units="dimensionless" type="e-notation">36<sep/>8</cn>
</apply>
</apply>
<apply>
<eq/>
<ci>V_A_Na</ci>
<apply>
<times/>
<apply>
<divide/>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
<apply>
<times/>
<ci>z_Na</ci>
<ci>F</ci>
</apply>
</apply>
<apply>
<ln/>
<apply>
<divide/>
<ci>q_Na_a</ci>
<ci>q_Na_c</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>I_ENaC</ci>
<apply>
<times/>
<apply>
<minus/>
<cn cellml:units="dimensionless" type="e-notation">1<sep/>+6</cn>
</apply>
<ci>G_ENaC</ci>
<ci>alpha_ENaC</ci>
<ci>A_Apical</ci>
<apply>
<minus/>
<ci>V_a</ci>
<ci>V_A_Na</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="BK">
<variable name="z_k" public_interface="in" units="dimensionless"/>
<variable name="R" public_interface="in" units="J_per_K_per_mol"/>
<variable name="T" public_interface="in" units="kelvin"/>
<variable name="q_K_c" public_interface="in" units="M"/>
<variable name="q_K_a" public_interface="in" units="M"/>
<variable name="q_Ca_c" public_interface="in" units="M"/>
<variable name="V_A_BK" public_interface="out" units="volt"/>
<variable name="V_a" public_interface="in" units="volt"/>
<variable name="J_BK" public_interface="out" units="umol_per_s"/>
<variable name="I_BK" public_interface="out" units="uA"/>
<variable name="A_Apical" public_interface="in" units="m2"/>
<variable name="F" public_interface="in" units="C_per_mol"/>
<variable initial_value="30" name="G_BK" public_interface="out" units="S"/>
<variable name="P_BK" public_interface="out" units="dimensionless"/>
<variable initial_value="0.0003" name="q_K_b_BK" public_interface="out" units="M"/>
<variable initial_value="1.7" name="eta" public_interface="out" units="dimensionless"/>
<!-- alpha is not multipled by area in order to have a dimensionless unit, so the unit is actually 1/m2, it's necessary to the same for CFTR as well-->
<variable initial_value="0.1" name="alpha_BK" public_interface="out" units="per_m2"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>P_BK</ci>
<apply>
<divide/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<power/>
<apply>
<divide/>
<ci>q_K_b_BK</ci>
<ci>q_Ca_c</ci>
</apply>
<ci>eta</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>V_A_BK</ci>
<apply>
<times/>
<apply>
<divide/>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
<apply>
<times/>
<ci>z_k</ci>
<ci>F</ci>
</apply>
</apply>
<apply>
<ln/>
<apply>
<divide/>
<ci>q_K_a</ci>
<ci>q_K_c</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>I_BK</ci>
<apply>
<times/>
<cn cellml:units="dimensionless" type="e-notation">1<sep/>+6</cn>
<ci>G_BK</ci>
<ci>alpha_BK</ci>
<ci>P_BK</ci>
<ci>A_Apical</ci>
<apply>
<minus/>
<ci>V_a</ci>
<ci>V_A_BK</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>J_BK</ci>
<apply>
<divide/>
<ci>I_BK</ci>
<ci>F</ci>
</apply>
</apply>
</math>
</component>
<!-- Basolateral_Membrane-->
<component name="GLUT2">
<variable initial_value="10" name="K_12" public_interface="out" units="per_M_per_second"/>
<variable initial_value="12.6" name="K_21" public_interface="out" units="per_second"/>
<variable initial_value="500" name="K_23" public_interface="out" units="per_second"/>
<variable initial_value="60" name="K_32" public_interface="out" units="per_second"/>
<variable initial_value="12.6" name="K_34" public_interface="out" units="per_second"/>
<variable initial_value="1" name="K_43" public_interface="out" units="per_M_per_second"/>
<variable initial_value="0.8" name="K_41" public_interface="out" units="per_second"/>
<variable initial_value="12" name="K_14" public_interface="out" units="per_second"/>
<variable name="q_Gl_c" public_interface="in" units="M"/>
<variable name="q_Gl_b" public_interface="in" units="M"/>
<variable name="K_S" public_interface="out" units="M"/>
<variable name="J_GLUT" public_interface="out" units="umol_per_s"/>
<variable name="C_tot" public_interface="out" units="mole"/>
<variable initial_value="15000000" name="n_GLUT" public_interface="out" units="dimensionless"/>
<variable name="D" public_interface="out" units="per_second"/>
<variable name="J_GLUT1" public_interface="out" units="umol_per_s"/>
<variable name="v_cell" public_interface="in" units="m3"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>C_tot</ci>
<apply>
<divide/>
<ci>n_GLUT</ci>
<cn cellml:units="per_mole" type="e-notation">6.022<sep/>23</cn>
</apply>
</apply>
<apply>
<eq/>
<ci>K_S</ci>
<apply>
<divide/>
<ci>K_21</ci>
<ci>K_12</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>J_GLUT</ci>
<apply>
<times/>
<apply>
<divide/>
<apply>
<times/>
<cn cellml:units="dimensionless" type="e-notation">1<sep/>6</cn>
<ci>C_tot</ci>
</apply>
<ci>D</ci>
</apply>
<apply>
<minus/>
<apply>
<divide/>
<apply>
<times/>
<ci>K_23</ci>
<ci>K_41</ci>
<ci>q_Gl_c</ci>
</apply>
<ci>K_S</ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>K_32</ci>
<ci>K_14</ci>
<ci>q_Gl_b</ci>
</apply>
<ci>K_S</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>J_GLUT1</ci>
<apply>
<times/>
<ci>J_GLUT</ci>
<cn cellml:units="dimensionless" type="e-notation">36<sep/>8</cn>
</apply>
</apply>
<apply>
<eq/>
<ci>D</ci>
<apply>
<plus/>
<apply>
<times/>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>q_Gl_c</ci>
<ci>K_S</ci>
</apply>
</apply>
<apply>
<plus/>
<apply>
<divide/>
<apply>
<times/>
<ci>K_32</ci>
<ci>q_Gl_b</ci>
</apply>
<ci>K_S</ci>
</apply>
<ci>K_41</ci>
</apply>
</apply>
<apply>
<times/>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>q_Gl_b</ci>
<ci>K_S</ci>
</apply>
</apply>
<apply>
<plus/>
<apply>
<divide/>
<apply>
<times/>
<ci>K_23</ci>
<ci>q_Gl_c</ci>
</apply>
<ci>K_S</ci>
</apply>
<ci>K_14</ci>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="NaK_Pump">
<variable name="t" public_interface="in" units="second"/>
<variable name="V_b" public_interface="in" units="volt"/>
<variable name="F" public_interface="in" units="C_per_mol"/>
<variable name="q_K_b" public_interface="in" units="M"/>
<variable name="q_Na_c" public_interface="in" units="M"/>
<variable name="TO_NaK" public_interface="out" units="per_second"/>
<variable initial_value="5000000" name="n_NaK" public_interface="out" units="dimensionless"/>
<variable initial_value="0.01" name="K_q_Na_c_half" public_interface="out" units="M"/>
<variable initial_value="0.0015" name="K_q_K_b_half" public_interface="out" units="M"/>
<variable name="I_Na_NaK" public_interface="out" units="uA"/>
<variable name="I_K_NaK" public_interface="out" units="uA"/>
<variable name="J_NaK" public_interface="out" units="umol_per_s"/>
<variable name="J_Na_NaK" public_interface="out" units="umol_per_s"/>
<variable name="J_K_NaK" public_interface="out" units="umol_per_s"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>I_K_NaK</ci>
<apply>
<times/>
<ci>J_K_NaK</ci>
<ci>F</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>I_Na_NaK</ci>
<apply>
<times/>
<ci>J_Na_NaK</ci>
<ci>F</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>J_NaK</ci>
<apply>
<divide/>
<apply>
<times/>
<apply>
<divide/>
<apply>
<times/>
<apply>
<divide/>
<apply>
<times/>
<ci>TO_NaK</ci>
<ci>n_NaK</ci>
</apply>
<cn cellml:units="per_umol" type="e-notation">6.023<sep/>17</cn>
</apply>
<apply>
<power/>
<ci>q_Na_c</ci>
<cn cellml:units="dimensionless">1.36</cn>
</apply>
<cn cellml:units="dimensionless">1.13</cn>
</apply>
<apply>
<plus/>
<apply>
<power/>
<ci>K_q_Na_c_half</ci>
<cn cellml:units="dimensionless">1.36</cn>
</apply>
<apply>
<power/>
<ci>q_Na_c</ci>
<cn cellml:units="dimensionless">1.36</cn>
</apply>
</apply>
</apply>
<cn cellml:units="dimensionless">1.3</cn>
<ci>q_K_b</ci>
</apply>
<apply>
<plus/>
<ci>K_q_K_b_half</ci>
<ci>q_K_b</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>TO_NaK</ci>
<apply>
<plus/>
<apply>
<minus/>
<apply>
<minus/>
<apply>
<times/>
<cn cellml:units="per_volt4_per_second" type="e-notation">5.46<sep/>+4</cn>
<apply>
<power/>
<ci>V_b</ci>
<cn cellml:units="dimensionless">4</cn>
</apply>
</apply>
<apply>
<times/>
<cn cellml:units="per_volt3_per_second" type="e-notation">2.43<sep/>+2</cn>
<apply>
<power/>
<ci>V_b</ci>
<cn cellml:units="dimensionless">3</cn>
</apply>
</apply>
</apply>
<apply>
<times/>
<cn cellml:units="per_volt2_per_second" type="e-notation">2<sep/>+3</cn>
<apply>
<power/>
<ci>V_b</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
<apply>
<times/>
<cn cellml:units="per_volt_per_second">160</cn>
<ci>V_b</ci>
</apply>
<cn cellml:units="per_second">51</cn>
</apply>
</apply>
<apply>
<eq/>
<ci>J_Na_NaK</ci>
<apply>
<times/>
<cn cellml:units="dimensionless">3</cn>
<ci>J_NaK</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>J_K_NaK</ci>
<apply>
<times/>
<cn cellml:units="dimensionless">2</cn>
<ci>J_NaK</ci>
</apply>
</apply>
</math>
</component>
<component name="NBC">
<variable name="t" public_interface="in" units="second"/>
<variable name="A_Apical" public_interface="in" units="m2"/>
<variable name="V_b" public_interface="in" units="volt"/>
<variable name="v_cell" public_interface="in" units="m3"/>
<variable name="q_Na_c" public_interface="in" units="M"/>
<variable name="q_Na_b" public_interface="in" units="M"/>
<variable name="q_HCO3_c" public_interface="in" units="M"/>
<variable initial_value="0.003" name="q_HCO3_b" public_interface="out" units="M"/>
<variable initial_value="0.01" name="g_NBC" public_interface="out" units="S_per_m2"/>
<variable name="F" public_interface="in" units="C_per_mol"/>
<variable name="R" public_interface="in" units="J_per_K_per_mol"/>
<variable name="T" public_interface="in" units="kelvin"/>
<variable initial_value="2" name="n" units="dimensionless"/>
<variable name="E_NBC" public_interface="out" units="volt"/>
<variable name="J_NBC_Na" public_interface="out" units="umol_per_s"/>
<variable name="J_NBC_HCO3" public_interface="out" units="umol_per_s"/>
<variable name="I_NBC_Na" public_interface="out" units="uA"/>
<variable name="I_NBC_HCO3" public_interface="out" units="uA"/>
<variable initial_value="1e-18" name="eps" units="M"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>E_NBC</ci>
<apply>
<times/>
<apply>
<divide/>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
<apply>
<times/>
<apply>
<minus/>
<cn cellml:units="dimensionless">1</cn>
<ci>n</ci>
</apply>
<ci>F</ci>
</apply>
</apply>
<apply>
<ln/>
<apply>
<times/>
<apply>
<divide/>
<ci>q_Na_b</ci>
<ci>q_Na_c</ci>
</apply>
<apply>
<power/>
<apply>
<divide/>
<ci>q_HCO3_b</ci>
<ci>q_HCO3_c</ci>
</apply>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>J_NBC_Na</ci>
<apply>
<divide/>
<apply>
<times/>
<cn cellml:units="dimensionless" type="e-notation">1<sep/>6</cn>
<ci>g_NBC</ci>
<ci>A_Apical</ci>
<apply>
<minus/>
<ci>E_NBC</ci>
<ci>V_b</ci>
</apply>
</apply>
<ci>F</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>J_NBC_HCO3</ci>
<apply>
<times/>
<cn cellml:units="dimensionless">3.0</cn>
<ci>J_NBC_Na</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>I_NBC_Na</ci>
<apply>
<times/>
<ci>J_NBC_Na</ci>
<ci>F</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>I_NBC_HCO3</ci>
<apply>
<times/>
<ci>J_NBC_HCO3</ci>
<ci>F</ci>
</apply>
</apply>
</math>
</component>
<component name="NKCC">
<variable name="A_Apical" public_interface="in" units="m2"/>
<variable name="S_C" public_interface="out" units="M"/>
<variable name="J_NKCC" public_interface="out" units="umol_per_s"/>
<variable name="I_NKCC" public_interface="out" units="uA"/>
<variable name="q_Na_c" public_interface="in" units="M"/>
<variable name="q_K_c" public_interface="in" units="M"/>
<variable name="q_Cl_c" public_interface="in" units="M"/>
<variable name="F" public_interface="in" units="C_per_mol"/>
<variable name="u_NKCC" public_interface="out" units="per_second"/>
<variable initial_value="157.55" name="gamma_1" public_interface="out" units="per_second2"/>
<variable initial_value="20000000" name="gamma_2" public_interface="out" units="per_M4_per_second2"/>
<variable initial_value="1.03" name="gamma_3" public_interface="out" units="per_second"/>
<variable initial_value="1380000" name="gamma_4" public_interface="out" units="per_M4_per_second"/>
<variable initial_value="1e-9" name="alpha_NKCC" public_interface="out" units="mole_per_m2"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>S_C</ci>
<apply>
<times/>
<ci>q_Na_c</ci>
<ci>q_Cl_c</ci>
<ci>q_Cl_c</ci>
<ci>q_K_c</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>u_NKCC</ci>
<apply>
<divide/>
<apply>
<minus/>
<ci>gamma_1</ci>
<apply>
<times/>
<ci>gamma_2</ci>
<ci>S_C</ci>
</apply>
</apply>
<apply>
<plus/>
<ci>gamma_3</ci>
<apply>
<times/>
<ci>gamma_4</ci>
<ci>S_C</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>J_NKCC</ci>
<apply>
<times/>
<apply>
<minus/>
<cn cellml:units="dimensionless" type="e-notation">1<sep/>6</cn>
</apply>
<ci>alpha_NKCC</ci>
<ci>u_NKCC</ci>
<ci>A_Apical</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>I_NKCC</ci>
<apply>
<times/>
<ci>J_NKCC</ci>
<ci>F</ci>
</apply>
</apply>
</math>
</component>
<component name="IK">
<variable name="z_k" public_interface="in" units="dimensionless"/>
<variable name="R" public_interface="in" units="J_per_K_per_mol"/>
<variable name="T" public_interface="in" units="kelvin"/>
<variable name="q_K_c" public_interface="in" units="M"/>
<variable name="q_K_b" public_interface="in" units="M"/>
<variable name="q_Ca_c" public_interface="in" units="M"/>
<variable name="V_A_IK" public_interface="out" units="volt"/>
<variable name="V_b" public_interface="in" units="volt"/>
<variable name="J_IK" public_interface="out" units="umol_per_s"/>
<variable name="I_IK" public_interface="out" units="uA"/>
<variable name="A_Apical" public_interface="in" units="m2"/>
<variable name="F" public_interface="in" units="C_per_mol"/>
<variable initial_value="24" name="G_IK" public_interface="out" units="S"/>
<variable name="P_IK" public_interface="out" units="dimensionless"/>
<variable initial_value="0.0003" name="q_K_b_IK" public_interface="out" units="M"/>
<variable initial_value="1.7" name="eta" public_interface="out" units="dimensionless"/>
<!-- alpha is not multipled by area in order to have a dimensionless unit, so the unit is actually 1/m2, it's necessary to the same for CFTR as well-->
<variable initial_value="1" name="alpha_IK" public_interface="out" units="per_m2"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>P_IK</ci>
<apply>
<divide/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<power/>
<apply>
<divide/>
<ci>q_K_b_IK</ci>
<ci>q_Ca_c</ci>
</apply>
<ci>eta</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>V_A_IK</ci>
<apply>
<times/>
<apply>
<divide/>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
<apply>
<times/>
<ci>z_k</ci>
<ci>F</ci>
</apply>
</apply>
<apply>
<ln/>
<apply>
<divide/>
<ci>q_K_b</ci>
<ci>q_K_c</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>I_IK</ci>
<apply>
<times/>
<cn cellml:units="dimensionless" type="e-notation">1<sep/>+6</cn>
<ci>G_IK</ci>
<ci>alpha_IK</ci>
<ci>P_IK</ci>
<ci>A_Apical</ci>
<apply>
<minus/>
<ci>V_b</ci>
<ci>V_A_IK</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>J_IK</ci>
<apply>
<divide/>
<ci>I_IK</ci>
<ci>F</ci>
</apply>
</apply>
</math>
</component>
<component name="Apical_Diffusion">
<variable name="V_a" public_interface="in" units="volt"/>
<variable name="q_Na_a" public_interface="in" units="M"/>
<variable name="q_K_a" public_interface="in" units="M"/>
<variable name="q_Cl_a" public_interface="in" units="M"/>
<variable name="q_Na_c" public_interface="in" units="M"/>
<variable name="q_K_c" public_interface="in" units="M"/>
<variable name="q_Cl_c" public_interface="in" units="M"/>
<variable name="F" public_interface="in" units="C_per_mol"/>
<variable name="z_Na" public_interface="in" units="dimensionless"/>
<variable name="z_k" public_interface="in" units="dimensionless"/>
<variable name="z_Cl" public_interface="in" units="dimensionless"/>
<variable name="R" public_interface="in" units="J_per_K_per_mol"/>
<variable name="A_Apical" public_interface="in" units="m2"/>
<variable name="T" public_interface="in" units="kelvin"/>
<variable name="P_Na" public_interface="in" units="m_per_s"/>
<variable name="P_k" public_interface="in" units="m_per_s"/>
<variable name="P_Cl" public_interface="in" units="m_per_s"/>
<variable name="J_D_Na" public_interface="out" units="umol_per_s"/>
<variable name="J_D_NA" public_interface="out" units="umol_per_s"/>
<variable name="I_D_Na" public_interface="out" units="uA"/>
<variable name="J_D_K" public_interface="out" units="umol_per_s"/>
<variable name="I_D_K" public_interface="out" units="uA"/>
<variable name="J_D_Cl" public_interface="out" units="umol_per_s"/>
<variable name="I_D_Cl" public_interface="out" units="uA"/>
<variable name="J_D_Apical" public_interface="out" units="umol_per_s"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>J_D_Na</ci>
<apply>
<times/>
<apply>
<divide/>
<apply>
<times/>
<apply>
<divide/>
<apply>
<times/>
<apply>
<minus/>
<cn cellml:units="litre_umol_per_mol_per_m3" type="e-notation">1<sep/>9</cn>
</apply>
<ci>P_Na</ci>
<ci>F</ci>
<ci>z_Na</ci>
<ci>V_a</ci>
</apply>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
<apply>
<minus/>
<ci>q_Na_a</ci>
<apply>
<times/>
<ci>q_Na_c</ci>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<times/>
<ci>z_Na</ci>
<ci>F</ci>
<ci>V_a</ci>
</apply>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<minus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<times/>
<ci>z_Na</ci>
<ci>F</ci>
<ci>V_a</ci>
</apply>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
<ci>A_Apical</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>J_D_NA</ci>
<apply>
<times/>
<cn cellml:units="dimensionless" type="e-notation">36<sep/>8</cn>
<ci>J_D_Na</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>I_D_Na</ci>
<apply>
<times/>
<ci>J_D_Na</ci>
<ci>F</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>J_D_K</ci>
<apply>
<times/>
<apply>
<divide/>
<apply>
<times/>
<apply>
<divide/>
<apply>
<times/>
<apply>
<minus/>
<cn cellml:units="litre_umol_per_mol_per_m3" type="e-notation">1<sep/>9</cn>
</apply>
<ci>P_k</ci>
<ci>F</ci>
<ci>z_k</ci>
<ci>V_a</ci>
</apply>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
<apply>
<minus/>
<ci>q_K_a</ci>
<apply>
<times/>
<ci>q_K_c</ci>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<times/>
<ci>z_k</ci>
<ci>F</ci>
<ci>V_a</ci>
</apply>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<minus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<times/>
<ci>z_k</ci>
<ci>F</ci>
<ci>V_a</ci>
</apply>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
<ci>A_Apical</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>I_D_K</ci>
<apply>
<times/>
<ci>J_D_K</ci>
<ci>F</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>J_D_Cl</ci>
<apply>
<times/>
<apply>
<divide/>
<apply>
<times/>
<apply>
<divide/>
<apply>
<times/>
<apply>
<minus/>
<cn cellml:units="litre_umol_per_mol_per_m3" type="e-notation">1<sep/>9</cn>
</apply>
<ci>P_Cl</ci>
<ci>F</ci>
<ci>z_Cl</ci>
<ci>V_a</ci>
</apply>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
<apply>
<minus/>
<ci>q_Cl_a</ci>
<apply>
<times/>
<ci>q_Cl_c</ci>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<times/>
<ci>z_Cl</ci>
<ci>F</ci>
<ci>V_a</ci>
</apply>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<minus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<times/>
<ci>z_Cl</ci>
<ci>F</ci>
<ci>V_a</ci>
</apply>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
<ci>A_Apical</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>I_D_Cl</ci>
<apply>
<times/>
<ci>J_D_Cl</ci>
<ci>F</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>J_D_Apical</ci>
<apply>
<plus/>
<ci>J_D_Na</ci>
<ci>J_D_K</ci>
<ci>J_D_Cl</ci>
</apply>
</apply>
</math>
</component>
<component name="Basolateral_Diffusion">
<variable name="V_b" public_interface="in" units="volt"/>
<variable name="q_Na_b" public_interface="in" units="M"/>
<variable name="q_K_b" public_interface="in" units="M"/>
<variable name="q_Cl_b" public_interface="in" units="M"/>
<variable name="q_Na_c" public_interface="in" units="M"/>
<variable name="q_K_c" public_interface="in" units="M"/>
<variable name="q_Cl_c" public_interface="in" units="M"/>
<variable name="F" public_interface="in" units="C_per_mol"/>
<variable name="z_Na" public_interface="in" units="dimensionless"/>
<variable name="z_k" public_interface="in" units="dimensionless"/>
<variable name="z_Cl" public_interface="in" units="dimensionless"/>
<variable name="R" public_interface="in" units="J_per_K_per_mol"/>
<variable name="A_Basol" public_interface="in" units="m2"/>
<variable name="T" public_interface="in" units="kelvin"/>
<variable name="P_Bl_Na" public_interface="in" units="m_per_s"/>
<variable name="P_Bl_k" public_interface="in" units="m_per_s"/>
<variable name="P_Bl_Cl" public_interface="in" units="m_per_s"/>
<variable name="J_D_Bl_Na" public_interface="out" units="umol_per_s"/>
<variable name="I_D_Bl_Na" public_interface="out" units="uA"/>
<variable name="J_D_Bl_K" public_interface="out" units="umol_per_s"/>
<variable name="I_D_Bl_K" public_interface="out" units="uA"/>
<variable name="J_D_Bl_Cl" public_interface="out" units="umol_per_s"/>
<variable name="I_D_Bl_Cl" public_interface="out" units="uA"/>
<variable name="J_D_Basolateral" public_interface="out" units="umol_per_s"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>J_D_Bl_Na</ci>
<apply>
<times/>
<apply>
<divide/>
<apply>
<times/>
<apply>
<divide/>
<apply>
<times/>
<apply>
<minus/>
<cn cellml:units="litre_umol_per_mol_per_m3" type="e-notation">1<sep/>9</cn>
</apply>
<ci>P_Bl_Na</ci>
<ci>F</ci>
<ci>z_Na</ci>
<ci>V_b</ci>
</apply>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
<apply>
<minus/>
<ci>q_Na_b</ci>
<apply>
<times/>
<ci>q_Na_c</ci>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<times/>
<ci>z_Na</ci>
<ci>F</ci>
<ci>V_b</ci>
</apply>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<minus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<times/>
<ci>z_Na</ci>
<ci>F</ci>
<ci>V_b</ci>
</apply>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
<ci>A_Basol</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>I_D_Bl_Na</ci>
<apply>
<times/>
<ci>J_D_Bl_Na</ci>
<ci>F</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>J_D_Bl_K</ci>
<apply>
<times/>
<apply>
<divide/>
<apply>
<times/>
<apply>
<divide/>
<apply>
<times/>
<apply>
<minus/>
<cn cellml:units="litre_umol_per_mol_per_m3" type="e-notation">1<sep/>9</cn>
</apply>
<ci>P_Bl_k</ci>
<ci>F</ci>
<ci>z_k</ci>
<ci>V_b</ci>
</apply>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
<apply>
<minus/>
<ci>q_K_b</ci>
<apply>
<times/>
<ci>q_K_c</ci>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<times/>
<ci>z_k</ci>
<ci>F</ci>
<ci>V_b</ci>
</apply>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<minus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<times/>
<ci>z_k</ci>
<ci>F</ci>
<ci>V_b</ci>
</apply>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
<ci>A_Basol</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>I_D_Bl_K</ci>
<apply>
<times/>
<ci>J_D_Bl_K</ci>
<ci>F</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>J_D_Bl_Cl</ci>
<apply>
<times/>
<apply>
<divide/>
<apply>
<times/>
<apply>
<divide/>
<apply>
<times/>
<apply>
<minus/>
<cn cellml:units="litre_umol_per_mol_per_m3" type="e-notation">1<sep/>9</cn>
</apply>
<ci>P_Bl_Cl</ci>
<ci>F</ci>
<ci>z_Cl</ci>
<ci>V_b</ci>
</apply>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
<apply>
<minus/>
<ci>q_Cl_b</ci>
<apply>
<times/>
<ci>q_Cl_c</ci>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<times/>
<ci>z_Cl</ci>
<ci>F</ci>
<ci>V_b</ci>
</apply>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<minus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<times/>
<ci>z_Cl</ci>
<ci>F</ci>
<ci>V_b</ci>
</apply>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
<ci>A_Basol</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>I_D_Bl_Cl</ci>
<apply>
<times/>
<ci>J_D_Bl_Cl</ci>
<ci>F</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>J_D_Basolateral</ci>
<apply>
<plus/>
<ci>J_D_Bl_Na</ci>
<ci>J_D_Bl_K</ci>
<ci>J_D_Bl_Cl</ci>
</apply>
</apply>
</math>
</component>
<component name="Paracellular_Pathway">
<variable name="V_ab" public_interface="out" units="volt"/>
<variable name="q_Na_a" public_interface="in" units="M"/>
<variable name="q_K_a" public_interface="in" units="M"/>
<variable name="q_Cl_a" public_interface="in" units="M"/>
<variable name="q_Na_b" public_interface="in" units="M"/>
<variable name="q_K_b" public_interface="in" units="M"/>
<variable name="q_Cl_b" public_interface="in" units="M"/>
<variable name="F" public_interface="in" units="C_per_mol"/>
<variable name="z_Na" public_interface="in" units="dimensionless"/>
<variable name="z_k" public_interface="in" units="dimensionless"/>
<variable name="z_Cl" public_interface="in" units="dimensionless"/>
<variable name="R" public_interface="in" units="J_per_K_per_mol"/>
<variable name="A_Apical" public_interface="in" units="m2"/>
<variable name="T" public_interface="in" units="kelvin"/>
<variable name="P_P_Na" public_interface="in" units="m_per_s"/>
<variable name="P_P_k" public_interface="in" units="m_per_s"/>
<variable name="P_P_Cl" public_interface="in" units="m_per_s"/>
<variable name="J_D_P_Na" public_interface="out" units="umol_per_s"/>
<variable name="I_D_P_Na" public_interface="out" units="uA"/>
<variable name="J_D_P_K" public_interface="out" units="umol_per_s"/>
<variable name="I_D_P_K" public_interface="out" units="uA"/>
<variable name="J_D_P_Cl" public_interface="out" units="umol_per_s"/>
<variable name="I_D_P_Cl" public_interface="out" units="uA"/>
<variable name="J_D_Paracellular" public_interface="out" units="umol_per_s"/>
<variable name="V_b" public_interface="in" units="volt"/>
<variable name="V_a" public_interface="in" units="volt"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>V_ab</ci>
<apply>
<minus/>
<ci>V_a</ci>
<ci>V_b</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>J_D_P_Na</ci>
<apply>
<times/>
<apply>
<divide/>
<apply>
<times/>
<apply>
<divide/>
<apply>
<times/>
<apply>
<minus/>
<cn cellml:units="litre_umol_per_mol_per_m3" type="e-notation">1<sep/>9</cn>
</apply>
<ci>P_P_Na</ci>
<ci>F</ci>
<ci>z_Na</ci>
<ci>V_ab</ci>
</apply>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
<apply>
<minus/>
<ci>q_Na_a</ci>
<apply>
<times/>
<ci>q_Na_b</ci>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<times/>
<ci>z_Na</ci>
<ci>F</ci>
<ci>V_ab</ci>
</apply>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<minus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<times/>
<ci>z_Na</ci>
<ci>F</ci>
<ci>V_ab</ci>
</apply>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
<ci>A_Apical</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>I_D_P_Na</ci>
<apply>
<times/>
<ci>J_D_P_Na</ci>
<ci>F</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>J_D_P_K</ci>
<apply>
<times/>
<apply>
<divide/>
<apply>
<times/>
<apply>
<divide/>
<apply>
<times/>
<apply>
<minus/>
<cn cellml:units="litre_umol_per_mol_per_m3" type="e-notation">1<sep/>9</cn>
</apply>
<ci>P_P_k</ci>
<ci>F</ci>
<ci>z_k</ci>
<ci>V_ab</ci>
</apply>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
<apply>
<minus/>
<ci>q_K_a</ci>
<apply>
<times/>
<ci>q_K_b</ci>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<times/>
<ci>z_k</ci>
<ci>F</ci>
<ci>V_ab</ci>
</apply>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<minus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<times/>
<ci>z_k</ci>
<ci>F</ci>
<ci>V_ab</ci>
</apply>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
<ci>A_Apical</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>I_D_P_K</ci>
<apply>
<times/>
<ci>J_D_P_K</ci>
<ci>F</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>J_D_P_Cl</ci>
<apply>
<times/>
<apply>
<divide/>
<apply>
<times/>
<apply>
<divide/>
<apply>
<times/>
<apply>
<minus/>
<cn cellml:units="litre_umol_per_mol_per_m3" type="e-notation">1<sep/>9</cn>
</apply>
<ci>P_P_Cl</ci>
<ci>F</ci>
<ci>z_Cl</ci>
<ci>V_ab</ci>
</apply>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
<apply>
<minus/>
<ci>q_Cl_a</ci>
<apply>
<times/>
<ci>q_Cl_b</ci>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<times/>
<ci>z_Cl</ci>
<ci>F</ci>
<ci>V_ab</ci>
</apply>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<minus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<times/>
<ci>z_Cl</ci>
<ci>F</ci>
<ci>V_ab</ci>
</apply>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
<ci>A_Apical</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>I_D_P_Cl</ci>
<apply>
<times/>
<ci>J_D_P_Cl</ci>
<ci>F</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>J_D_Paracellular</ci>
<apply>
<plus/>
<ci>J_D_P_Na</ci>
<ci>J_D_P_K</ci>
<ci>J_D_P_Cl</ci>
</apply>
</apply>
</math>
</component>
<component name="Parameters">
<variable initial_value="-1" name="z_Cl" public_interface="out" units="dimensionless"/>
<variable initial_value="1" name="z_Na" public_interface="out" units="dimensionless"/>
<variable initial_value="1" name="z_k" public_interface="out" units="dimensionless"/>
<variable initial_value="96485" name="F" public_interface="out" units="C_per_mol"/>
<variable initial_value="8.314" name="R" public_interface="out" units="J_per_K_per_mol"/>
<variable initial_value="310" name="T" public_interface="out" units="kelvin"/>
<variable initial_value="1e-5" name="C" public_interface="out" units="uF"/>
<variable initial_value="8.4e-10" name="A_Apical" public_interface="out" units="m2"/>
<variable initial_value="5e-10" name="A_Basol" public_interface="out" units="m2"/>
<variable initial_value="5e-16" name="v_cell" public_interface="out" units="m3"/>
<variable initial_value="0" name="P_Na" public_interface="out" units="m_per_s"/>
<variable initial_value="0" name="P_k" public_interface="out" units="m_per_s"/>
<variable initial_value="0" name="P_Cl" public_interface="out" units="m_per_s"/>
<variable initial_value="1e-6" name="P_P_Na" public_interface="out" units="m_per_s"/>
<variable initial_value="1e-6" name="P_P_k" public_interface="out" units="m_per_s"/>
<variable initial_value="3e-8" name="P_P_Cl" public_interface="out" units="m_per_s"/>
<variable initial_value="0" name="P_Bl_Na" public_interface="out" units="m_per_s"/>
<variable initial_value="0" name="P_Bl_k" public_interface="out" units="m_per_s"/>
<variable initial_value="0" name="P_Bl_Cl" public_interface="out" units="m_per_s"/>
<variable name="t" public_interface="out" units="second"/>
<variable initial_value="14000" name="k0_12" public_interface="out" units="per_M2_per_second"/>
<variable initial_value="300" name="k0_21" public_interface="out" units="per_second"/>
<variable initial_value="15000" name="k0_23" public_interface="out" units="per_M_per_second"/>
<variable initial_value="20" name="k0_32" public_interface="out" units="per_second"/>
<variable initial_value="0.1" name="k0_25" public_interface="out" units="per_second"/>
<variable initial_value="0.01" name="k0_52" public_interface="out" units="per_second"/>
<variable initial_value="50" name="k0_34" public_interface="out" units="per_second"/>
<variable initial_value="50" name="k0_43" public_interface="out" units="per_second"/>
<variable initial_value="6" name="k0_45" public_interface="out" units="per_second"/>
<variable initial_value="400" name="k0_54" public_interface="out" units="per_M_per_second"/>
<variable initial_value="10" name="k0_56" public_interface="out" units="per_second"/>
<variable initial_value="200" name="k0_65" public_interface="out" units="per_M2_per_second"/>
<variable initial_value="25" name="k0_61" public_interface="out" units="per_second"/>
<variable initial_value="600" name="k0_16" public_interface="out" units="per_second"/>
<variable initial_value="0.7" name="delta" public_interface="out" units="dimensionless"/>
<variable initial_value="0.3" name="alpha_p" public_interface="out" units="dimensionless"/>
<variable initial_value="0" name="alpha_pp" public_interface="out" units="dimensionless"/>
<variable initial_value="2" name="n" public_interface="out" units="dimensionless"/>
<variable initial_value="-2" name="z_c" public_interface="out" units="dimensionless"/>
<variable name="V_a" public_interface="in" units="volt"/>
<variable name="mu" public_interface="out" units="dimensionless"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>mu</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>F</ci>
<ci>V_a</ci>
</apply>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="Rate_Constants">
<variable name="q_Na_c" public_interface="in" units="M"/>
<variable name="q_Na_a" public_interface="in" units="M"/>
<variable name="q_Gl_c" public_interface="in" units="M"/>
<variable name="q_Gl_a" public_interface="in" units="M"/>
<variable name="k_12" public_interface="out" units="per_second"/>
<variable name="ks_12" public_interface="out" units="per_M2_per_second"/>
<variable name="k_21" public_interface="out" units="per_second"/>
<variable name="k_32" public_interface="out" units="per_second"/>
<variable name="k_25" public_interface="out" units="per_second"/>
<variable name="k_52" public_interface="out" units="per_second"/>
<variable name="k_34" public_interface="out" units="per_second"/>
<variable name="k_43" public_interface="out" units="per_second"/>
<variable name="k_45" public_interface="out" units="per_second"/>
<variable name="k_54" public_interface="out" units="per_second"/>
<variable name="k_56" public_interface="out" units="per_second"/>
<variable name="k_65" public_interface="out" units="per_second"/>
<variable name="k_61" public_interface="out" units="per_second"/>
<variable name="k_16" public_interface="out" units="per_second"/>
<variable name="k0_12" public_interface="in" units="per_M2_per_second"/>
<variable name="k0_21" public_interface="in" units="per_second"/>
<variable name="k0_32" public_interface="in" units="per_second"/>
<variable name="k0_25" public_interface="in" units="per_second"/>
<variable name="k0_52" public_interface="in" units="per_second"/>
<variable name="k0_34" public_interface="in" units="per_second"/>
<variable name="k0_43" public_interface="in" units="per_second"/>
<variable name="k0_45" public_interface="in" units="per_second"/>
<variable name="k0_54" public_interface="in" units="per_M_per_second"/>
<variable name="k0_56" public_interface="in" units="per_second"/>
<variable name="k0_65" public_interface="in" units="per_M2_per_second"/>
<variable name="k0_61" public_interface="in" units="per_second"/>
<variable name="k0_16" public_interface="in" units="per_second"/>
<variable name="delta" public_interface="in" units="dimensionless"/>
<variable name="n" public_interface="in" units="dimensionless"/>
<variable name="z_c" public_interface="in" units="dimensionless"/>
<variable name="z_Na" public_interface="in" units="dimensionless"/>
<variable name="alpha_p" public_interface="in" units="dimensionless"/>
<variable name="mu" public_interface="in" units="dimensionless"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>ks_12</ci>
<apply>
<times/>
<ci>k0_12</ci>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<times/>
<apply>
<minus/>
<ci>n</ci>
</apply>
<ci>alpha_p</ci>
<ci>mu</ci>
</apply>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>k_12</ci>
<apply>
<times/>
<ci>k0_12</ci>
<apply>
<exp/>
<apply>
<times/>
<apply>
<minus/>
<ci>alpha_p</ci>
</apply>
<ci>mu</ci>
</apply>
</apply>
<apply>
<power/>
<ci>q_Na_a</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>k_21</ci>
<apply>
<times/>
<ci>k0_21</ci>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<times/>
<ci>n</ci>
<ci>z_Na</ci>
<ci>alpha_p</ci>
<ci>mu</ci>
</apply>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>k_32</ci>
<ci>k0_32</ci>
</apply>
<apply>
<eq/>
<ci>k_34</ci>
<ci>k0_34</ci>
</apply>
<apply>
<eq/>
<ci>k_43</ci>
<ci>k0_43</ci>
</apply>
<apply>
<eq/>
<ci>k_45</ci>
<ci>k0_45</ci>
</apply>
<apply>
<eq/>
<ci>k_54</ci>
<apply>
<times/>
<ci>k0_54</ci>
<ci>q_Gl_c</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>k_25</ci>
<ci>k0_25</ci>
</apply>
<apply>
<eq/>
<ci>k_56</ci>
<ci>k0_56</ci>
</apply>
<apply>
<eq/>
<ci>k_65</ci>
<apply>
<times/>
<ci>k0_65</ci>
<apply>
<power/>
<ci>q_Na_c</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>k_61</ci>
<apply>
<times/>
<ci>k0_61</ci>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<times/>
<ci>z_c</ci>
<ci>delta</ci>
<ci>mu</ci>
</apply>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>k_16</ci>
<apply>
<times/>
<ci>k0_16</ci>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<times/>
<apply>
<minus/>
<ci>z_c</ci>
</apply>
<ci>delta</ci>
<ci>mu</ci>
</apply>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>k_52</ci>
<ci>k0_52</ci>
</apply>
</math>
</component>
<!-- Mapping Apical Membrane-->
<connection>
<map_components component_1="Apical_Membrane" component_2="SGLT1"/>
<map_variables variable_1="q_Na_a" variable_2="q_Na_a"/>
<map_variables variable_1="q_Gl_a" variable_2="q_Gl_a"/>
<map_variables variable_1="I_Na_SGLT" variable_2="I_Na_SGLT"/>
</connection>
<connection>
<map_components component_1="Apical_Membrane" component_2="GLUT2_Apical"/>
<map_variables variable_1="q_Gl_a" variable_2="q_Gl_a"/>
</connection>
<connection>
<map_components component_1="Apical_Membrane" component_2="NHE3"/>
<map_variables variable_1="I_NHE3_H" variable_2="I_NHE3_H"/>
<map_variables variable_1="I_NHE3_Na" variable_2="I_NHE3_Na"/>
<map_variables variable_1="q_Na_a" variable_2="q_Na_a"/>
</connection>
<connection>
<map_components component_1="Apical_Membrane" component_2="AE1"/>
<map_variables variable_1="q_Cl_a" variable_2="q_Cl_a"/>
</connection>
<connection>
<map_components component_1="Apical_Membrane" component_2="CFTR"/>
<map_variables variable_1="q_Cl_a" variable_2="q_Cl_a"/>
<map_variables variable_1="V_a" variable_2="V_a"/>
<map_variables variable_1="I_CFTR" variable_2="I_CFTR"/>
</connection>
<connection>
<map_components component_1="Apical_Membrane" component_2="ENaC"/>
<map_variables variable_1="q_Na_a" variable_2="q_Na_a"/>
<map_variables variable_1="V_a" variable_2="V_a"/>
<map_variables variable_1="I_ENaC" variable_2="I_ENaC"/>
</connection>
<connection>
<map_components component_1="Apical_Membrane" component_2="BK"/>
<map_variables variable_1="q_K_a" variable_2="q_K_a"/>
<map_variables variable_1="V_a" variable_2="V_a"/>
<map_variables variable_1="I_BK" variable_2="I_BK"/>
</connection>
<connection>
<map_components component_1="Apical_Membrane" component_2="Apical_Diffusion"/>
<map_variables variable_1="I_D_Na" variable_2="I_D_Na"/>
<map_variables variable_1="I_D_K" variable_2="I_D_K"/>
<map_variables variable_1="I_D_Cl" variable_2="I_D_Cl"/>
<map_variables variable_1="V_a" variable_2="V_a"/>
<map_variables variable_1="q_Na_a" variable_2="q_Na_a"/>
<map_variables variable_1="q_K_a" variable_2="q_K_a"/>
<map_variables variable_1="q_Cl_a" variable_2="q_Cl_a"/>
</connection>
<connection>
<map_components component_1="Apical_Membrane" component_2="Paracellular_Pathway"/>
<map_variables variable_1="q_Na_a" variable_2="q_Na_a"/>
<map_variables variable_1="q_K_a" variable_2="q_K_a"/>
<map_variables variable_1="q_Cl_a" variable_2="q_Cl_a"/>
<map_variables variable_1="I_D_P_Na" variable_2="I_D_P_Na"/>
<map_variables variable_1="I_D_P_K" variable_2="I_D_P_K"/>
<map_variables variable_1="I_D_P_Cl" variable_2="I_D_P_Cl"/>
<map_variables variable_1="V_a" variable_2="V_a"/>
</connection>
<connection>
<map_components component_1="Apical_Membrane" component_2="Parameters"/>
<map_variables variable_1="C" variable_2="C"/>
<map_variables variable_1="t" variable_2="t"/>
<map_variables variable_1="V_a" variable_2="V_a"/>
</connection>
<connection>
<map_components component_1="Apical_Membrane" component_2="Rate_Constants"/>
<map_variables variable_1="q_Na_a" variable_2="q_Na_a"/>
<map_variables variable_1="q_Gl_a" variable_2="q_Gl_a"/>
</connection>
<!-- Mapping Epithelial Cell-->
<connection>
<map_components component_1="Epithelial_Cell" component_2="SGLT1"/>
<map_variables variable_1="J_Na_SGLT" variable_2="J_Na_SGLT"/>
<map_variables variable_1="J_Gl_SGLT" variable_2="J_Gl_SGLT"/>
</connection>
<connection>
<map_components component_1="Epithelial_Cell" component_2="GLUT2"/>
<map_variables variable_1="q_Gl_c" variable_2="q_Gl_c"/>
<map_variables variable_1="J_GLUT" variable_2="J_GLUT"/>
</connection>
<connection>
<map_components component_1="Epithelial_Cell" component_2="GLUT2_Apical"/>
<map_variables variable_1="q_Gl_c" variable_2="q_Gl_c"/>
<map_variables variable_1="J_A_GLUT" variable_2="J_A_GLUT"/>
</connection>
<connection>
<map_components component_1="Epithelial_Cell" component_2="NHE3"/>
<map_variables variable_1="q_Na_c" variable_2="q_Na_c"/>
<map_variables variable_1="q_H_int" variable_2="q_H_int"/>
<map_variables variable_1="q_H_ext" variable_2="q_H_ext"/>
<map_variables variable_1="J_NHE3_Na" variable_2="J_NHE3_Na"/>
<map_variables variable_1="J_NHE3_H" variable_2="J_NHE3_H"/>
</connection>
<connection>
<map_components component_1="Epithelial_Cell" component_2="AE1"/>
<map_variables variable_1="q_Cl_c" variable_2="q_Cl_c"/>
<map_variables variable_1="q_HCO3_c" variable_2="q_HCO3_c"/>
<map_variables variable_1="q_HCO3_a" variable_2="q_HCO3_a"/>
<map_variables variable_1="J_AE1_Cl" variable_2="J_AE1_Cl"/>
<map_variables variable_1="J_AE1_HCO3" variable_2="J_AE1_HCO3"/>
</connection>
<connection>
<map_components component_1="Epithelial_Cell" component_2="NaK_Pump"/>
<map_variables variable_1="q_Na_c" variable_2="q_Na_c"/>
<map_variables variable_1="J_Na_NaK" variable_2="J_Na_NaK"/>
<map_variables variable_1="J_K_NaK" variable_2="J_K_NaK"/>
</connection>
<connection>
<map_components component_1="Epithelial_Cell" component_2="NBC"/>
<map_variables variable_1="q_Na_c" variable_2="q_Na_c"/>
<map_variables variable_1="J_NBC_Na" variable_2="J_NBC_Na"/>
<map_variables variable_1="J_NBC_HCO3" variable_2="J_NBC_HCO3"/>
<map_variables variable_1="q_HCO3_c" variable_2="q_HCO3_c"/>
</connection>
<connection>
<map_components component_1="Epithelial_Cell" component_2="CFTR"/>
<map_variables variable_1="q_Cl_c" variable_2="q_Cl_c"/>
<map_variables variable_1="q_HCO3_c" variable_2="q_HCO3_c"/>
<map_variables variable_1="q_HCO3_a" variable_2="q_HCO3_a"/>
<map_variables variable_1="J_CFTR" variable_2="J_CFTR"/>
<map_variables variable_1="J_CFTR_HCO3" variable_2="J_CFTR_HCO3"/>
</connection>
<connection>
<map_components component_1="Epithelial_Cell" component_2="ENaC"/>
<map_variables variable_1="q_Na_c" variable_2="q_Na_c"/>
<map_variables variable_1="J_ENaC" variable_2="J_ENaC"/>
</connection>
<connection>
<map_components component_1="Epithelial_Cell" component_2="NKCC"/>
<map_variables variable_1="q_Na_c" variable_2="q_Na_c"/>
<map_variables variable_1="q_Cl_c" variable_2="q_Cl_c"/>
<map_variables variable_1="q_K_c" variable_2="q_K_c"/>
<map_variables variable_1="J_NKCC" variable_2="J_NKCC"/>
</connection>
<connection>
<map_components component_1="Epithelial_Cell" component_2="IK"/>
<map_variables variable_1="q_K_c" variable_2="q_K_c"/>
<map_variables variable_1="q_Ca_c" variable_2="q_Ca_c"/>
<map_variables variable_1="J_IK" variable_2="J_IK"/>
</connection>
<connection>
<map_components component_1="Epithelial_Cell" component_2="BK"/>
<map_variables variable_1="q_K_c" variable_2="q_K_c"/>
<map_variables variable_1="q_Ca_c" variable_2="q_Ca_c"/>
<map_variables variable_1="J_BK" variable_2="J_BK"/>
</connection>
<connection>
<map_components component_1="Epithelial_Cell" component_2="Apical_Diffusion"/>
<map_variables variable_1="q_Na_c" variable_2="q_Na_c"/>
<map_variables variable_1="q_K_c" variable_2="q_K_c"/>
<map_variables variable_1="q_Cl_c" variable_2="q_Cl_c"/>
<map_variables variable_1="J_D_Na" variable_2="J_D_Na"/>
<map_variables variable_1="J_D_K" variable_2="J_D_K"/>
<map_variables variable_1="J_D_Cl" variable_2="J_D_Cl"/>
</connection>
<connection>
<map_components component_1="Epithelial_Cell" component_2="Basolateral_Diffusion"/>
<map_variables variable_1="q_Na_c" variable_2="q_Na_c"/>
<map_variables variable_1="q_K_c" variable_2="q_K_c"/>
<map_variables variable_1="q_Cl_c" variable_2="q_Cl_c"/>
<map_variables variable_1="J_D_Bl_Na" variable_2="J_D_Bl_Na"/>
<map_variables variable_1="J_D_Bl_K" variable_2="J_D_Bl_K"/>
<map_variables variable_1="J_D_Bl_Cl" variable_2="J_D_Bl_Cl"/>
</connection>
<connection>
<map_components component_1="Epithelial_Cell" component_2="Paracellular_Pathway"/>
<map_variables variable_1="J_D_P_Na" variable_2="J_D_P_Na"/>
</connection>
<connection>
<map_components component_1="Epithelial_Cell" component_2="Parameters"/>
<map_variables variable_1="v_cell" variable_2="v_cell"/>
<map_variables variable_1="t" variable_2="t"/>
<map_variables variable_1="A_Apical" variable_2="A_Apical"/>
</connection>
<connection>
<map_components component_1="Epithelial_Cell" component_2="Rate_Constants"/>
<map_variables variable_1="q_Na_c" variable_2="q_Na_c"/>
<map_variables variable_1="q_Gl_c" variable_2="q_Gl_c"/>
</connection>
<!-- Mapping Basolateral Membrane-->
<connection>
<map_components component_1="Basolateral_Membrane" component_2="GLUT2"/>
<map_variables variable_1="q_Gl_b" variable_2="q_Gl_b"/>
</connection>
<connection>
<map_components component_1="Basolateral_Membrane" component_2="NaK_Pump"/>
<map_variables variable_1="q_K_b" variable_2="q_K_b"/>
<map_variables variable_1="I_Na_NaK" variable_2="I_Na_NaK"/>
<map_variables variable_1="I_K_NaK" variable_2="I_K_NaK"/>
<map_variables variable_1="V_b" variable_2="V_b"/>
</connection>
<connection>
<map_components component_1="Basolateral_Membrane" component_2="NBC"/>
<map_variables variable_1="V_b" variable_2="V_b"/>
<map_variables variable_1="I_NBC_HCO3" variable_2="I_NBC_HCO3"/>
<map_variables variable_1="I_NBC_Na" variable_2="I_NBC_Na"/>
<map_variables variable_1="q_Na_b" variable_2="q_Na_b"/>
</connection>
<connection>
<map_components component_1="Basolateral_Membrane" component_2="IK"/>
<map_variables variable_1="q_K_b" variable_2="q_K_b"/>
<map_variables variable_1="V_b" variable_2="V_b"/>
<map_variables variable_1="I_IK" variable_2="I_IK"/>
</connection>
<connection>
<map_components component_1="Basolateral_Membrane" component_2="Paracellular_Pathway"/>
<map_variables variable_1="V_b" variable_2="V_b"/>
<map_variables variable_1="I_D_P_Na" variable_2="I_D_P_Na"/>
<map_variables variable_1="I_D_P_K" variable_2="I_D_P_K"/>
<map_variables variable_1="I_D_P_Cl" variable_2="I_D_P_Cl"/>
<map_variables variable_1="q_Na_b" variable_2="q_Na_b"/>
<map_variables variable_1="q_K_b" variable_2="q_K_b"/>
<map_variables variable_1="q_Cl_b" variable_2="q_Cl_b"/>
</connection>
<connection>
<map_components component_1="Basolateral_Membrane" component_2="Basolateral_Diffusion"/>
<map_variables variable_1="q_Na_b" variable_2="q_Na_b"/>
<map_variables variable_1="q_K_b" variable_2="q_K_b"/>
<map_variables variable_1="q_Cl_b" variable_2="q_Cl_b"/>
<map_variables variable_1="I_D_Bl_Na" variable_2="I_D_Bl_Na"/>
<map_variables variable_1="I_D_Bl_K" variable_2="I_D_Bl_K"/>
<map_variables variable_1="I_D_Bl_Cl" variable_2="I_D_Bl_Cl"/>
<map_variables variable_1="V_b" variable_2="V_b"/>
</connection>
<connection>
<map_components component_1="Basolateral_Membrane" component_2="Blood"/>
<map_variables variable_1="q_Gl_b" variable_2="q_Gl_b"/>
</connection>
<connection>
<map_components component_1="Basolateral_Membrane" component_2="Parameters"/>
<map_variables variable_1="C" variable_2="C"/>
<map_variables variable_1="t" variable_2="t"/>
</connection>
<!-- Mapping Parameters-->
<connection>
<map_components component_1="Parameters" component_2="SGLT1"/>
<map_variables variable_1="k0_23" variable_2="k0_23"/>
<map_variables variable_1="F" variable_2="F"/>
</connection>
<connection>
<map_components component_1="Parameters" component_2="NHE3"/>
<map_variables variable_1="F" variable_2="F"/>
<map_variables variable_1="A_Apical" variable_2="A_Apical"/>
<map_variables variable_1="v_cell" variable_2="v_cell"/>
</connection>
<connection>
<map_components component_1="Parameters" component_2="AE1"/>
<map_variables variable_1="F" variable_2="F"/>
<map_variables variable_1="A_Apical" variable_2="A_Apical"/>
<map_variables variable_1="v_cell" variable_2="v_cell"/>
</connection>
<connection>
<map_components component_1="Parameters" component_2="GLUT2"/>
<map_variables variable_1="v_cell" variable_2="v_cell"/>
</connection>
<connection>
<map_components component_1="Parameters" component_2="NaK_Pump"/>
<map_variables variable_1="F" variable_2="F"/>
<map_variables variable_1="t" variable_2="t"/>
</connection>
<connection>
<map_components component_1="Parameters" component_2="NBC"/>
<map_variables variable_1="F" variable_2="F"/>
<map_variables variable_1="t" variable_2="t"/>
<map_variables variable_1="R" variable_2="R"/>
<map_variables variable_1="T" variable_2="T"/>
<map_variables variable_1="A_Apical" variable_2="A_Apical"/>
<map_variables variable_1="v_cell" variable_2="v_cell"/>
</connection>
<connection>
<map_components component_1="Parameters" component_2="BK"/>
<map_variables variable_1="F" variable_2="F"/>
<map_variables variable_1="z_k" variable_2="z_k"/>
<map_variables variable_1="R" variable_2="R"/>
<map_variables variable_1="T" variable_2="T"/>
<map_variables variable_1="A_Apical" variable_2="A_Apical"/>
</connection>
<connection>
<map_components component_1="Parameters" component_2="NKCC"/>
<map_variables variable_1="F" variable_2="F"/>
<map_variables variable_1="A_Apical" variable_2="A_Apical"/>
</connection>
<connection>
<map_components component_1="Parameters" component_2="Apical_Diffusion"/>
<map_variables variable_1="F" variable_2="F"/>
<map_variables variable_1="z_Na" variable_2="z_Na"/>
<map_variables variable_1="z_k" variable_2="z_k"/>
<map_variables variable_1="z_Cl" variable_2="z_Cl"/>
<map_variables variable_1="R" variable_2="R"/>
<map_variables variable_1="T" variable_2="T"/>
<map_variables variable_1="A_Apical" variable_2="A_Apical"/>
<map_variables variable_1="P_Na" variable_2="P_Na"/>
<map_variables variable_1="P_k" variable_2="P_k"/>
<map_variables variable_1="P_Cl" variable_2="P_Cl"/>
</connection>
<connection>
<map_components component_1="Parameters" component_2="Basolateral_Diffusion"/>
<map_variables variable_1="F" variable_2="F"/>
<map_variables variable_1="z_Na" variable_2="z_Na"/>
<map_variables variable_1="z_k" variable_2="z_k"/>
<map_variables variable_1="z_Cl" variable_2="z_Cl"/>
<map_variables variable_1="R" variable_2="R"/>
<map_variables variable_1="T" variable_2="T"/>
<map_variables variable_1="A_Basol" variable_2="A_Basol"/>
<map_variables variable_1="P_Bl_Na" variable_2="P_Bl_Na"/>
<map_variables variable_1="P_Bl_k" variable_2="P_Bl_k"/>
<map_variables variable_1="P_Bl_Cl" variable_2="P_Bl_Cl"/>
</connection>
<connection>
<map_components component_1="Parameters" component_2="Paracellular_Pathway"/>
<map_variables variable_1="F" variable_2="F"/>
<map_variables variable_1="z_Na" variable_2="z_Na"/>
<map_variables variable_1="z_k" variable_2="z_k"/>
<map_variables variable_1="z_Cl" variable_2="z_Cl"/>
<map_variables variable_1="R" variable_2="R"/>
<map_variables variable_1="T" variable_2="T"/>
<map_variables variable_1="A_Apical" variable_2="A_Apical"/>
<map_variables variable_1="P_P_Na" variable_2="P_P_Na"/>
<map_variables variable_1="P_P_k" variable_2="P_P_k"/>
<map_variables variable_1="P_P_Cl" variable_2="P_P_Cl"/>
</connection>
<connection>
<map_components component_1="Parameters" component_2="Blood"/>
<map_variables variable_1="t" variable_2="t"/>
</connection>
<connection>
<map_components component_1="Parameters" component_2="CFTR"/>
<map_variables variable_1="F" variable_2="F"/>
<map_variables variable_1="z_Cl" variable_2="z_Cl"/>
<map_variables variable_1="R" variable_2="R"/>
<map_variables variable_1="T" variable_2="T"/>
<map_variables variable_1="A_Apical" variable_2="A_Apical"/>
</connection>
<connection>
<map_components component_1="Parameters" component_2="ENaC"/>
<map_variables variable_1="F" variable_2="F"/>
<map_variables variable_1="z_Na" variable_2="z_Na"/>
<map_variables variable_1="R" variable_2="R"/>
<map_variables variable_1="T" variable_2="T"/>
<map_variables variable_1="A_Apical" variable_2="A_Apical"/>
</connection>
<connection>
<map_components component_1="Parameters" component_2="IK"/>
<map_variables variable_1="F" variable_2="F"/>
<map_variables variable_1="z_k" variable_2="z_k"/>
<map_variables variable_1="R" variable_2="R"/>
<map_variables variable_1="T" variable_2="T"/>
<map_variables variable_1="A_Apical" variable_2="A_Apical"/>
</connection>
<connection>
<map_components component_1="Parameters" component_2="GLUT2_Apical"/>
<map_variables variable_1="v_cell" variable_2="v_cell"/>
</connection>
<connection>
<map_components component_1="Parameters" component_2="Rate_Constants"/>
<map_variables variable_1="k0_12" variable_2="k0_12"/>
<map_variables variable_1="k0_21" variable_2="k0_21"/>
<map_variables variable_1="k0_32" variable_2="k0_32"/>
<map_variables variable_1="k0_25" variable_2="k0_25"/>
<map_variables variable_1="k0_52" variable_2="k0_52"/>
<map_variables variable_1="k0_34" variable_2="k0_34"/>
<map_variables variable_1="k0_43" variable_2="k0_43"/>
<map_variables variable_1="k0_45" variable_2="k0_45"/>
<map_variables variable_1="k0_54" variable_2="k0_54"/>
<map_variables variable_1="k0_56" variable_2="k0_56"/>
<map_variables variable_1="k0_65" variable_2="k0_65"/>
<map_variables variable_1="k0_61" variable_2="k0_61"/>
<map_variables variable_1="k0_16" variable_2="k0_16"/>
<map_variables variable_1="delta" variable_2="delta"/>
<map_variables variable_1="alpha_p" variable_2="alpha_p"/>
<map_variables variable_1="n" variable_2="n"/>
<map_variables variable_1="z_c" variable_2="z_c"/>
<map_variables variable_1="z_Na" variable_2="z_Na"/>
<map_variables variable_1="mu" variable_2="mu"/>
</connection>
<connection>
<map_components component_1="Rate_Constants" component_2="SGLT1"/>
<map_variables variable_1="ks_12" variable_2="ks_12"/>
<map_variables variable_1="k_12" variable_2="k_12"/>
<map_variables variable_1="k_21" variable_2="k_21"/>
<map_variables variable_1="k_32" variable_2="k_32"/>
<map_variables variable_1="k_25" variable_2="k_25"/>
<map_variables variable_1="k_52" variable_2="k_52"/>
<map_variables variable_1="k_34" variable_2="k_34"/>
<map_variables variable_1="k_43" variable_2="k_43"/>
<map_variables variable_1="k_45" variable_2="k_45"/>
<map_variables variable_1="k_54" variable_2="k_54"/>
<map_variables variable_1="k_56" variable_2="k_56"/>
<map_variables variable_1="k_65" variable_2="k_65"/>
<map_variables variable_1="k_61" variable_2="k_61"/>
<map_variables variable_1="k_16" variable_2="k_16"/>
</connection>
</model>