Location: Activation of the Liver Glycogen Phosphorylase by Ca2+ Oscillations: a Theoretical Study @ adae8cbbf412 / gall_2000b.cellml

Author:

dave <dave@bcs.co.nz>

Date:

2013-01-04 12:32:00+13:00

Desc:

Correctly define units for all variables.

Permanent Source URI:

https://models.physiomeproject.org/workspace/35d/rawfile/adae8cbbf41290ed1f54c55c5407edaae8f63fd6/gall_2000b.cellml

<?xml version="1.0"?>

<!--

This CellML file was generated on 8/18/2011 at 1:28:59 at PM using:



COR (0.9.31.1409)

Copyright 2002-2011 Dr Alan Garny

http://cor.physiol.ox.ac.uk/ - cor@physiol.ox.ac.uk



CellML 1.0 was used to generate this model

http://www.cellml.org/

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         Made in COR. Model a runs in OpenCell to recreate results from  published paper but model b does not reproduce results. CellML files are based on equations 1-3 (a) and 1 and 4-8 (b).

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      <sect1 id="sec_structure">

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ABSTRACT: Cytosolic calcium plays a crucial role as a second messenger in cellular signalling. Various cell types, including hepatocytes, display Ca(2+)oscillations when stimulated by an extracellular signal. However, the biological relevance of this temporal organization remains unclear. In this paper, we investigate theoretically the effect of Ca(2+)oscillations on a particular example of cell regulation: the phosphorylation-dephosphorylation cycle controlling the activation of glycogen phosphorylase in hepatocytes. By modelling periodic sinusoidal variations in the intracellular Ca(2+)concentration, we show that Ca(2+)oscillations reduce the threshold for the activation of the enzyme. Furthermore, as the activation of a given enzyme depends on the kinetics of its phosphorylation-dephosphorylation cycle, specificity can be encoded by the oscillation frequency. Finally, using a model for signal-induced Ca(2+)oscillations based on Ca(2+)-induced Ca(2+)release, we show that realistic Ca(2+)oscillations can potentiate the response to a hormonal stimulation. These results indicate that Ca(2+)oscillations in hepatocytes could contribute to increase the efficiency and specificity of cellular signalling, as shown experimentally for gene expression in lymphocytes (Dolmetsch et al., 1998).</para>



        <para>

The complete original paper reference is cited below:

</para>

        <para>

         Activation of the Liver Glycogen Phosphorylase by Ca2+ Oscillations: a Theoretical Study, David Gall et al, 2009, <emphasis>Activation of the Liver Glycogen Phosphorylase by Ca2+ Oscillations: 

a Theoretical Study </emphasis>, 207, 445-454. <ulink url="http://www.ncbi.nlm.nih.gov/pubmed/11093832">PubMed ID: 11093832</ulink>

        </para>

		

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           Activation of the liver glycogen phosphorylase by Ca(2+)oscillations: a theoretical study

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