- Author:
- dhanya.herath <dhanya.herath@gmail.com>
- Date:
- 2016-09-26 20:45:14+13:00
- Desc:
- SED-ml files added
- Permanent Source URI:
- https://models.physiomeproject.org/workspace/35a/rawfile/8b52d8562bf3008f28a7aa7fffa86c3b461d439e/goldbeter_1990_1.1.cellml
<?xml version="1.0"?>
<model xmlns="http://www.cellml.org/cellml/1.1#" name="goldbeter_1990_1.1"><import xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="goldbeter_1990_units.cellml"><units name="s" units_ref="s"/><units name="per_s" units_ref="per_s"/><units name="uM" units_ref="uM"/><units name="uM_per_s" units_ref="uM_per_s"/></import><component name="environment"><variable name="time" public_interface="out" units="s"/></component><component name="Ca"><math xmlns="http://www.w3.org/1998/Math/MathML" id=""><apply id="endoplasmic_equation"><eq/><apply><diff/><bvar><ci>time</ci></bvar><ci>Z</ci></apply><apply><minus/><apply><plus/><apply><minus/><apply><plus/><ci>v_0</ci><apply><times/><ci>v_1</ci><ci>beta</ci></apply></apply><ci>v_2</ci></apply><ci>v_3</ci><apply><times/><ci>k_f</ci><ci>Y</ci></apply></apply><apply><times/><ci>k</ci><ci>Z</ci></apply></apply></apply><apply id="sarcoplasmic_equation"><eq/><apply><diff/><bvar><ci>time</ci></bvar><ci>Y</ci></apply><apply><minus/><apply><minus/><ci>v_2</ci><ci>v_3</ci></apply><apply><times/><ci>k_f</ci><ci>Y</ci></apply></apply></apply></math><variable name="time" public_interface="in" units="s"/><variable initial_value="1" name="v_0" units="uM_per_s"/><variable initial_value="7.3" name="v_1" units="uM_per_s"/><variable name="v_2" private_interface="in" public_interface="in" units="uM_per_s"/><variable name="v_3" private_interface="in" public_interface="in" units="uM_per_s"/><variable initial_value="0.301" name="beta" units="dimensionless"/><variable initial_value="1" name="k_f" units="per_s"/><variable initial_value="10" name="k" units="per_s"/><variable initial_value="1.75" name="Y" private_interface="out" public_interface="out" units="uM"/><variable initial_value="0.5" name="Z" private_interface="out" public_interface="out" units="uM"/></component><connection><map_components component_1="environment" component_2="Ca"/><map_variables variable_1="time" variable_2="time"/></connection><component name="v_2"><math xmlns="http://www.w3.org/1998/Math/MathML" id="v_2_maths"><apply id="v_2_equation"><eq/><ci>v_2</ci><apply><times/><ci>V_M2</ci><apply><divide/><apply><power/><ci>Z</ci><ci>n</ci></apply><apply><plus/><apply><power/><ci>K_2</ci><ci>n</ci></apply><apply><power/><ci>Z</ci><ci>n</ci></apply></apply></apply></apply></apply></math><variable name="v_2" public_interface="out" units="uM_per_s"/><variable initial_value="65" name="V_M2" units="uM_per_s"/><variable name="Z" public_interface="in" units="uM"/><variable initial_value="1" name="K_2" units="uM"/><variable initial_value="2" name="n" units="dimensionless"/></component><component name="v_3"><math xmlns="http://www.w3.org/1998/Math/MathML" id="v_3_maths"><apply id="v_3_equation"><eq/><ci>v_3</ci><apply><times/><ci>V_M3</ci><apply><divide/><apply><power/><ci>Y</ci><ci>m</ci></apply><apply><plus/><apply><power/><ci>K_R</ci><ci>m</ci></apply><apply><power/><ci>Y</ci><ci>m</ci></apply></apply></apply><apply><divide/><apply><power/><ci>Z</ci><ci>p</ci></apply><apply><plus/><apply><power/><ci>K_A</ci><ci>p</ci></apply><apply><power/><ci>Z</ci><ci>p</ci></apply></apply></apply></apply></apply></math><variable name="v_3" public_interface="out" units="uM_per_s"/><variable initial_value="500" name="V_M3" units="uM_per_s"/><variable name="Y" public_interface="in" units="uM"/><variable name="Z" public_interface="in" units="uM"/><variable initial_value="0.9" name="K_A" units="uM"/><variable initial_value="2" name="K_R" units="uM"/><variable initial_value="2" name="m" units="dimensionless"/><variable initial_value="4" name="p" units="dimensionless"/></component><connection><map_components component_1="Ca" component_2="v_2"/><map_variables variable_1="Z" variable_2="Z"/><map_variables variable_1="v_2" variable_2="v_2"/></connection><connection><map_components component_1="Ca" component_2="v_3"/><map_variables variable_1="Y" variable_2="Y"/><map_variables variable_1="Z" variable_2="Z"/><map_variables variable_1="v_3" variable_2="v_3"/></connection><component name="W_star"><math xmlns="http://www.w3.org/1998/Math/MathML" id="W_star_maths"><apply id="W_star_equation"><eq/><apply><diff/><bvar><ci>time</ci></bvar><ci>W_star</ci></apply><apply><times/><apply><divide/><ci>v_P</ci><ci>W_T</ci></apply><apply><minus/><apply><times/><apply><divide/><ci>v_K</ci><ci>v_P</ci></apply><apply><divide/><apply><minus/><cn xmlns:cellml="http://www.cellml.org/cellml/1.1#" cellml:units="dimensionless">1</cn><ci>W_star</ci></apply><apply><plus/><ci>K_1</ci><cn xmlns:cellml="http://www.cellml.org/cellml/1.1#" cellml:units="dimensionless">1</cn><apply><minus/><ci>W_star</ci></apply></apply></apply></apply><apply><divide/><ci>W_star</ci><apply><plus/><ci>K_2</ci><ci>W_star</ci></apply></apply></apply></apply></apply></math><variable name="time" public_interface="in" units="s"/><variable initial_value="0" name="W_star" public_interface="out" units="dimensionless"/><variable name="Z" private_interface="out" public_interface="in" units="uM"/><variable initial_value="1" name="W_T" units="uM"/><variable initial_value="5" name="v_P" units="uM_per_s"/><variable name="v_K" private_interface="in" units="uM_per_s"/><variable initial_value="0.1" name="K_1" units="dimensionless"/><variable initial_value="0.1" name="K_2" units="dimensionless"/></component><connection><map_components component_1="environment" component_2="W_star"/><map_variables variable_1="time" variable_2="time"/></connection><connection><map_components component_1="W_star" component_2="Ca"/><map_variables variable_1="Z" variable_2="Z"/></connection><component name="v_K"><math xmlns="http://www.w3.org/1998/Math/MathML" id="v_K_maths"><apply id="v_K_equation"><eq/><ci>v_K</ci><apply><times/><ci>V_MK</ci><apply><divide/><ci>Z</ci><apply><plus/><ci>K_a</ci><ci>Z</ci></apply></apply></apply></apply></math><variable name="v_K" public_interface="out" units="uM_per_s"/><variable initial_value="40" name="V_MK" units="uM_per_s"/><variable name="Z" public_interface="in" units="uM"/><variable initial_value="2.5" name="K_a" units="uM"/></component><connection><map_components component_1="W_star" component_2="v_K"/><map_variables variable_1="v_K" variable_2="v_K"/><map_variables variable_1="Z" variable_2="Z"/></connection><group><component_ref component="Ca"><component_ref component="v_2"/><component_ref component="v_3"/></component_ref><relationship_ref relationship="encapsulation"/><component_ref component="W_star"><component_ref component="v_K"/></component_ref></group></model>