- Author:
- Tessa Paris <tpar054@aucklanduni.ac.nz>
- Date:
- 2009-11-25 12:32:22+13:00
- Desc:
- Fixed equations and dimensions and added fast, slow and medium bursting models
- Permanent Source URI:
- https://models.physiomeproject.org/workspace/2e0/rawfile/54be3996f711871d6a9c0f9fd81013d4caf355a7/bertram_previte_sherman_kinard_satin_2000_fast.cellml
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<title>The Phantom Burster Model For Pancreatic Beta-Cells</title>
<author>
<firstname>James</firstname>
<surname>Lawson</surname>
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<shortaffil>Bioengineering Institute, University of Auckland</shortaffil>
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<title>Model Status</title>
<para> This model has been rebuilt according to the author's original XPPAUT code, which can be found <ulink url="http://www.math.fsu.edu/~bertram/software/islet/BJ_04a.ode">here</ulink>. This version of the CellML model represents the fast bursting model where gs1=20. The model replicates figure 2 in the published paper. The model runs in both PCEnv and COR and the units are consistent. </para>
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<para>
Pancreatic beta-cells have been the subject of both experimental and theoretical studies for several decades. One reason for this interest has been the essential role beta-cells play in glucose homeostasis - they are the only source of insulin that most cells require in order to take up and metabolise glucose, and impairment of beta-cell function contributes to diabetes. A major focus of theoretical work has been beta-cell dynamics, especially in the form of bursting electrical activity. The bursts consist of active phases of Ca<superscript>2+</superscript>
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<para>
Experimentally, electrical activity in beta-cells is studied in two distinct preparations: islets of Langerhans, which are microorgans containing thousands of endocrine cells, and isolated cells. Pancreatic beta-cells exhibit bursting oscillations with a wide range of periods. Whereas periods in isolated cells are generally either a few seconds or a few minutes, in intact islets of Langerhans they are intermediate (10-60 seconds). In their 2000 publication, Richard Bertram, Joseph Previte, Arthur Sherman, Tracie A. Kinard and Leslie S. Satin develop a mathematical model for beta-cell electrical activity capable of generating this wide range of bursting oscillations. Unlike previously published models, bursting is driven by the interaction of two slow processes (I<subscript>s1</subscript>
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<para>The complete original paper reference is cited below:</para>
<para>
The Phantom Burster Model for Pancreatic beta-Cells, Richard Bertram, Joseph Previte, Arthur Sherman, Tracie A. Kinard and Leslie S. Satin, 2000,
<emphasis>Biophysical Journal</emphasis>, 79, 2880-2892. <ulink url="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=11106596&dopt=Abstract">PubMed ID: 11106596</ulink>
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<caption>Schematic diagram of the pancreatic beta-cell plasma membrane showing the ionic currents captured by the phantom burster model.</caption>
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The Bertram et al 2000 phantom burster model for pancreatic beta-cells.
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Added publication date information.
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