Location: Bertram, Previte, Sherman, Kinard, Satin, 2000 @ 54be3996f711 / bertram_previte_sherman_kinard_satin_2000_fast.cellml

Author:
Tessa Paris <tpar054@aucklanduni.ac.nz>
Date:
2009-11-25 12:32:22+13:00
Desc:
Fixed equations and dimensions and added fast, slow and medium bursting models
Permanent Source URI:
https://models.physiomeproject.org/workspace/2e0/rawfile/54be3996f711871d6a9c0f9fd81013d4caf355a7/bertram_previte_sherman_kinard_satin_2000_fast.cellml

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            <article>
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                        <title>The Phantom Burster Model For Pancreatic Beta-Cells</title>
                        <author>
                              <firstname>James</firstname>
                              <surname>Lawson</surname>
                              <affiliation>
                                    <shortaffil>Bioengineering Institute, University of Auckland</shortaffil>
                              </affiliation>
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                  <section id="sec_status">
                        <title>Model Status</title>
                        <para> This model has been rebuilt according to the author's original XPPAUT code, which can be found <ulink url="http://www.math.fsu.edu/~bertram/software/islet/BJ_04a.ode">here</ulink>. This version of the CellML model represents the fast bursting model where gs1=20.  The model replicates figure 2 in the published paper.  The model runs in both PCEnv and COR and the units are consistent.						</para>
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                        <title>Model Structure</title>
                        <para>
                              Pancreatic beta-cells have been the subject of both experimental and theoretical studies for several decades. One reason for this interest has been the essential role beta-cells play in glucose homeostasis - they are the only source of insulin that most cells require in order to take up and metabolise glucose, and impairment of beta-cell function contributes to diabetes. A major focus of theoretical work has been beta-cell dynamics, especially in the form of bursting electrical activity. The bursts consist of active phases of Ca<superscript>2+</superscript>
                              -carrying action potentials alternating with silent phases of repolarisation and are accompanied by oscillations in cytosolic Ca<superscript>2+</superscript>
                        , which drive pulses of insulin secretion.</para>
                        <para>
                              Experimentally, electrical activity in beta-cells is studied in two distinct preparations: islets of Langerhans, which are microorgans containing thousands of endocrine cells, and isolated cells. Pancreatic beta-cells exhibit bursting oscillations with a wide range of periods. Whereas periods in isolated cells are generally either a few seconds or a few minutes, in intact islets of Langerhans they are intermediate (10-60 seconds). In their 2000 publication, Richard Bertram, Joseph Previte, Arthur Sherman, Tracie A. Kinard and Leslie S. Satin develop a mathematical model for beta-cell electrical activity capable of generating this wide range of bursting oscillations. Unlike previously published models, bursting is driven by the interaction of two slow processes (I<subscript>s1</subscript>
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                              below), one with a relatively small time constant (1-5 seconds) and the other with a much larger time constant (1-2 minutes). Bursting on the intermediate time scale is generated without the need for a slow process having an intermediate time constant, hence phantom bursting. This mathematical model has been translated into a CellML description which can be downloaded in various formats as described in <xref linkend="sec_download_this_model"/>
                        .</para>
                        <para>The complete original paper reference is cited below:</para>
                        <para>
                              The Phantom Burster Model for Pancreatic beta-Cells, Richard Bertram, Joseph Previte, Arthur Sherman, Tracie A. Kinard and Leslie S. Satin, 2000,
                                    <emphasis>Biophysical Journal</emphasis>, 79, 2880-2892. <ulink url="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;list_uids=11106596&amp;dopt=Abstract">PubMed ID: 11106596</ulink>
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                              <caption>Schematic diagram of the pancreatic beta-cell plasma membrane showing the ionic currents captured by the phantom burster model.</caption>
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