Location: Na+/HCO3- Cotransporter @ d7e8ded17754 / Ostby_2009_NBC.cellml

Author:
Soroush Safaei <ssaf006@aucklanduni.ac.nz>
Date:
2016-04-14 17:27:21+12:00
Desc:
fix the name
Permanent Source URI:
https://models.physiomeproject.org/workspace/295/rawfile/d7e8ded1775417f792da593d7dbcb1f3bda343f8/Ostby_2009_NBC.cellml

<?xml version='1.0'?>
<!-- This CellML file was generated from:
 Østby, Ivar, et al. "Astrocytic mechanisms explaining neural-activity-induced shrinkage of extraneuronal space." PLoS Comput Biol 5.1 (2009): e1000272.-->
<model cmeta:id="Ostby_2009_NBC" name="Ostby_2009_NBC" xmlns="http://www.cellml.org/cellml/1.1#" xmlns:cellml="http://www.cellml.org/cellml/1.1#" xmlns:cmeta="http://www.cellml.org/metadata/1.0#" xmlns:xlink="http://www.w3.org/1999/xlink">
    <import xlink:href="Units/Units.cellml">
        <units name="mM" units_ref="mM"/>
        <units name="mM_per_s" units_ref="mM_per_s"/>
        <units name="joule_per_mmole_kelvin" units_ref="joule_per_mmole_kelvin"/>
        <units name="coulomb_per_mmole" units_ref="coulomb_per_mmole"/>
        <units name="mS_per_cm2" units_ref="mS_per_cm2"/>
    </import>
    <component name="NBC">
        <variable name="V_m" public_interface="in" units="volt"/>
        <variable name="Na_int" public_interface="in" units="mM"/>
        <variable name="Na_ext" public_interface="in" units="mM"/>
        <variable name="HCO3_int" public_interface="in" units="mM"/>
        <variable name="HCO3_ext" public_interface="in" units="mM"/>
        <variable initial_value="0.08" name="g_NBC" public_interface="out" units="mS_per_cm2"/>
        <variable initial_value="96.5" name="F" units="coulomb_per_mmole"/>
        <variable initial_value="0.008315" name="R" units="joule_per_mmole_kelvin"/>
        <variable initial_value="300" name="T" units="kelvin"/>
        <variable initial_value="2" name="n" units="dimensionless"/>
        <variable name="E_NBC" public_interface="out" units="volt"/>
        <variable name="J_NBC_Na" public_interface="out" units="mM_per_s"/>
        <variable name="J_NBC_HCO3" public_interface="out" units="mM_per_s"/>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
                <eq/>
                <ci>E_NBC</ci>
                <apply>
                    <times/>
                    <apply>
                        <divide/>
                        <apply>
                            <times/>
                            <ci>R</ci>
                            <ci>T</ci>
                        </apply>
                        <apply>
                            <times/>
                            <apply>
                                <minus/>
                                <cn cellml:units="dimensionless">1</cn>
                                <ci>n</ci>
                            </apply>
                            <ci>F</ci>
                        </apply>
                    </apply>
                    <apply>
                        <ln/>
                        <apply>
                            <times/>
                            <apply>
                                <divide/>
                                <ci>Na_ext</ci>
                                <ci>Na_int</ci>
                            </apply>
                            <apply>
                                <power/>
                                <apply>
                                    <divide/>
                                    <ci>HCO3_ext</ci>
                                    <ci>HCO3_int</ci>
                                </apply>
                                <cn cellml:units="dimensionless">2</cn>
                            </apply>
                        </apply>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>J_NBC_Na</ci>
                <apply>
                    <divide/>
                    <apply>
                        <times/>
                        <ci>g_NBC</ci>
                        <apply>
                            <minus/>
                            <ci>E_NBC</ci>
                            <ci>V_m</ci>
                        </apply>
                    </apply>
                    <ci>F</ci>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>J_NBC_HCO3</ci>
                <apply>
                    <times/>
                    <cn cellml:units="dimensionless">3.0</cn>
                    <ci>J_NBC_Na</ci>
                </apply>
            </apply>
        </math>
    </component>
    <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
        <rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="">
            <dc:title xmlns:dc="http://purl.org/dc/elements/1.1/">A kinetic model of Na+/HCO3- cotransporter (NBC)</dc:title>
        </rdf:Description>
        <rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="#Oyehaug_2009_NBC">
            <bqs:reference xmlns:bqs="http://www.cellml.org/bqs/1.0#" rdf:parseType="Resource" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
                <dc:subject xmlns:dc="http://purl.org/dc/elements/1.1/" rdf:parseType="Resource" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
                    <bqs:subject_type xmlns:bqs="http://www.cellml.org/bqs/1.0#">keyword</bqs:subject_type>
                    <rdf:value xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
                        <rdf:Bag xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
                            <rdf:li xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">protein module</rdf:li>
                        </rdf:Bag>
                    </rdf:value>
                </dc:subject>
            </bqs:reference>
        </rdf:Description>
    </rdf:RDF>
</model>