Location: Na+/HCO3- Cotransporter @ 6b1e3506d19b / Ostby_2009_NBC.cellml

Author:
Soroush Safaei <ssaf006@aucklanduni.ac.nz>
Date:
2016-07-20 14:53:25+12:00
Desc:
fix units
Permanent Source URI:
https://models.physiomeproject.org/workspace/295/rawfile/6b1e3506d19bdcc8936047781338bf42f37a63cb/Ostby_2009_NBC.cellml

<?xml version='1.0'?>
<!-- This CellML file was generated from:
 Ostby, Ivar, et al. "Astrocytic mechanisms explaining neural-activity-induced shrinkage of extraneuronal space." PLoS Comput Biol 5.1 (2009): e1000272.-->
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    <import xlink:href="Units/Units.cellml">
        <units name="mV" units_ref="mV"/>
        <units name="mM" units_ref="mM"/>
        <units name="C_per_mol" units_ref="C_per_mol"/>
        <units name="mJ_per_mol_per_kelvin" units_ref="mJ_per_mol_per_kelvin"/>
        <units name="umol_per_s_per_cm2" units_ref="umol_per_s_per_cm2"/>
        <units name="mS_per_cm2" units_ref="mS_per_cm2"/>
    </import>
    <component name="NBC">
        <variable name="V_m" public_interface="in" units="mV"/>
        <variable name="Na_int" public_interface="in" units="mM"/>
        <variable name="Na_ext" public_interface="in" units="mM"/>
        <variable name="HCO3_int" public_interface="in" units="mM"/>
        <variable name="HCO3_ext" public_interface="in" units="mM"/>
        <variable initial_value="0.08" name="g_NBC" public_interface="out" units="mS_per_cm2"/>
        <variable initial_value="96485" name="F" units="C_per_mol"/>
        <variable initial_value="8314.41" name="R" units="mJ_per_mol_per_kelvin"/>
        <variable initial_value="300" name="T" units="kelvin"/>
        <variable initial_value="2" name="n" units="dimensionless"/>
        <variable initial_value="1e-15" name="eps" units="mM"/>
        <variable name="E_NBC" public_interface="out" units="mV"/>
        <variable name="J_NBC_Na" public_interface="out" units="umol_per_s_per_cm2"/>
        <variable name="J_NBC_HCO3" public_interface="out" units="umol_per_s_per_cm2"/>
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                <eq/>
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                        <divide/>
                        <apply>
                            <times/>
                            <ci>R</ci>
                            <ci>T</ci>
                        </apply>
                        <apply>
                            <times/>
                            <apply>
                                <minus/>
                                <cn cellml:units="dimensionless">1</cn>
                                <ci>n</ci>
                            </apply>
                            <ci>F</ci>
                        </apply>
                    </apply>
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                        <ln/>
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                                <apply>
                                    <plus/>
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                                </apply>
                                <apply>
                                    <plus/>
                                    <ci>Na_int</ci>
                                    <ci>eps</ci>
                                </apply>
                            </apply>
                            <apply>
                                <power/>
                                <apply>
                                    <divide/>
                                    <apply>
                                        <plus/>
                                        <ci>HCO3_ext</ci>
                                        <ci>eps</ci>
                                    </apply>
                                    <apply>
                                        <plus/>
                                        <ci>HCO3_int</ci>
                                        <ci>eps</ci>
                                    </apply>
                                </apply>
                                <cn cellml:units="dimensionless">2</cn>
                            </apply>
                        </apply>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
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                <apply>
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                        <apply>
                            <minus/>
                            <ci>E_NBC</ci>
                            <ci>V_m</ci>
                        </apply>
                    </apply>
                    <ci>F</ci>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>J_NBC_HCO3</ci>
                <apply>
                    <times/>
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                    <ci>J_NBC_Na</ci>
                </apply>
            </apply>
        </math>
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            <dc:title xmlns:dc="http://purl.org/dc/elements/1.1/">A kinetically defined Na+/HCO3- cotransporter (NBC) within a mathematical model of the brain.</dc:title>
        </rdf:Description>
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