Location: Na+/K+-ATPase (sodium-potassium pump) @ e3002995c54f / BG-simplified / NaK_BG.cellml

Author:
Soroush Safaei <ssaf006@aucklanduni.ac.nz>
Date:
2017-04-04 14:36:57+12:00
Desc:
changing the svg diagram
Permanent Source URI:
https://models.physiomeproject.org/workspace/294/rawfile/e3002995c54f9399b800e7b7d7b8011fd817f499/BG-simplified/NaK_BG.cellml

<?xml version='1.0'?>
<model name="NaK_BG" xmlns="http://www.cellml.org/cellml/1.1#" xmlns:cellml="http://www.cellml.org/cellml/1.1#" xmlns:xlink="http://www.w3.org/1999/xlink">
    <import xlink:href="Units.cellml">
        <units name="per_mol" units_ref="per_mol"/>
        <units name="J_per_mol" units_ref="J_per_mol"/>
        <units name="mol_per_s" units_ref="mol_per_s"/>
        <units name="per_C" units_ref="per_C"/>
        <units name="J_per_C" units_ref="J_per_C"/>
        <units name="C_per_s" units_ref="C_per_s"/>
        <units name="C_per_mol" units_ref="C_per_mol"/>
    </import>
    <import xlink:href="StateDiagram.cellml">
        <component component_ref="state" name="state"/>
    </import>
    <import xlink:href="Parameters.cellml">
        <component component_ref="param" name="param"/>
    </import>
    <component name="module">
        <variable name="time" private_interface="out" units="second"/>
        <variable initial_value="2494.34" name="RT" private_interface="out" units="J_per_mol"/>
        <variable initial_value="2" name="z" private_interface="out" units="dimensionless"/>
        <variable initial_value="96485" name="F" private_interface="out" units="C_per_mol"/>
        <!-- State variables-->
        <variable initial_value="1e-6" name="q_0_Na_o" private_interface="out" units="mole"/>
        <variable initial_value="0.05" name="q_0_Na_i" private_interface="out" units="mole"/>
        <variable initial_value="0.0054" name="q_0_K_o" private_interface="out" units="mole"/>
        <variable initial_value="0.14" name="q_0_K_i" private_interface="out" units="mole"/>
        <variable initial_value="0.0098" name="q_0_ATP" private_interface="out" units="mole"/>
        <variable initial_value="0.00005" name="q_0_ADP" private_interface="out" units="mole"/>
        <variable initial_value="0.0042" name="q_0_Pi" private_interface="out" units="mole"/>
        <variable initial_value="0.1" name="q_0_PE_o" private_interface="out" units="mole"/>
        <variable initial_value="0.1" name="q_0_PE2K_o" private_interface="out" units="mole"/>
        <variable initial_value="0.1" name="q_0_E2K_o" private_interface="out" units="mole"/>
        <variable initial_value="0.1" name="q_0_ATPE2K_o" private_interface="out" units="mole"/>
        <variable initial_value="0.1" name="q_0_ATPE2K_i" private_interface="out" units="mole"/>
        <variable initial_value="0.1" name="q_0_ATPE_i" private_interface="out" units="mole"/>
        <variable initial_value="0.1" name="q_0_ATPE3Na_i" private_interface="out" units="mole"/>
        <variable initial_value="0.1" name="q_0_PE3Na_o" private_interface="out" units="mole"/>
        <variable initial_value="0.1" name="q_0_PE3Na_i" private_interface="out" units="mole"/>
        <variable initial_value="0.000000" name="q_0_E" private_interface="out" units="mole"/>
        <variable name="q_Na_o" private_interface="in" units="mole"/>
        <variable name="q_Na_i" private_interface="in" units="mole"/>
        <variable name="q_K_o" private_interface="in" units="mole"/>
        <variable name="q_K_i" private_interface="in" units="mole"/>
        <variable name="q_ATP" private_interface="in" units="mole"/>
        <variable name="q_ADP" private_interface="in" units="mole"/>
        <variable name="q_Pi" private_interface="in" units="mole"/>
        <variable name="q_PE_o" private_interface="in" units="mole"/>
        <variable name="q_PE2K_o" private_interface="in" units="mole"/>
        <variable name="q_E2K_o" private_interface="in" units="mole"/>
        <variable name="q_ATPE2K_o" private_interface="in" units="mole"/>
        <variable name="q_ATPE2K_i" private_interface="in" units="mole"/>
        <variable name="q_ATPE_i" private_interface="in" units="mole"/>
        <variable name="q_ATPE3Na_i" private_interface="in" units="mole"/>
        <variable name="q_PE3Na_i" private_interface="in" units="mole"/>
        <variable name="q_PE3Na_o" private_interface="in" units="mole"/>
        <variable name="q_E" private_interface="in" units="mole"/>
        <variable name="v_Re1" private_interface="in" units="mol_per_s"/>
        <variable name="v_Re2" private_interface="in" units="mol_per_s"/>
        <variable name="v_Re3" private_interface="in" units="mol_per_s"/>
        <variable name="v_Re4" private_interface="in" units="mol_per_s"/>
        <variable name="v_Re5" private_interface="in" units="mol_per_s"/>
        <variable name="v_Re6" private_interface="in" units="mol_per_s"/>
        <variable name="v_Re7" private_interface="in" units="mol_per_s"/>
        <variable name="v_Re8" private_interface="in" units="mol_per_s"/>
        <variable name="v_Re9" private_interface="in" units="mol_per_s"/>
        <variable name="u_Na_o" private_interface="in" units="J_per_mol"/>
        <variable name="u_Na_i" private_interface="in" units="J_per_mol"/>
        <variable name="u_K_o" private_interface="in" units="J_per_mol"/>
        <variable name="u_K_i" private_interface="in" units="J_per_mol"/>
        <variable name="u_ATP" private_interface="in" units="J_per_mol"/>
        <variable name="u_ADP" private_interface="in" units="J_per_mol"/>
        <variable name="u_Pi" private_interface="in" units="J_per_mol"/>
        <variable name="u_PE_o" private_interface="in" units="J_per_mol"/>
        <variable name="u_PE2K_o" private_interface="in" units="J_per_mol"/>
        <variable name="u_E2K_o" private_interface="in" units="J_per_mol"/>
        <variable name="u_ATPE2K_o" private_interface="in" units="J_per_mol"/>
        <variable name="u_ATPE2K_i" private_interface="in" units="J_per_mol"/>
        <variable name="u_ATPE_i" private_interface="in" units="J_per_mol"/>
        <variable name="u_ATPE3Na_i" private_interface="in" units="J_per_mol"/>
        <variable name="u_PE3Na_i" private_interface="in" units="J_per_mol"/>
        <variable name="u_PE3Na_o" private_interface="in" units="J_per_mol"/>
        <variable name="u17" private_interface="in" units="J_per_mol"/>
        <variable name="u18" private_interface="in" units="J_per_mol"/>
        <variable name="u19" private_interface="in" units="J_per_mol"/>
        <variable name="u20" private_interface="in" units="J_per_mol"/>
        <variable name="u21" private_interface="in" units="J_per_mol"/>
        <variable name="u22" private_interface="in" units="J_per_mol"/>
        <variable name="u23" private_interface="in" units="J_per_mol"/>
        <variable name="u24" private_interface="in" units="J_per_mol"/>
        <variable name="u_E" private_interface="in" units="J_per_C"/>
        <!--        ode(q_0_Na_o, time) = 0.005{mol_per_s};
        ode(q_0_E, time) = 0.001{coulomb};-->
    </component>
    <!-- Mapping to the BG state diagram-->
    <connection>
        <map_components component_1="module" component_2="state"/>
        <map_variables variable_1="time" variable_2="t"/>
        <map_variables variable_1="RT" variable_2="RT"/>
        <map_variables variable_1="z" variable_2="z"/>
        <map_variables variable_1="F" variable_2="F"/>
        <map_variables variable_1="q_0_Na_o" variable_2="q1_init"/>
        <map_variables variable_1="q_0_Na_i" variable_2="q2_init"/>
        <map_variables variable_1="q_0_K_o" variable_2="q3_init"/>
        <map_variables variable_1="q_0_K_i" variable_2="q4_init"/>
        <map_variables variable_1="q_0_ATP" variable_2="q5_init"/>
        <map_variables variable_1="q_0_ADP" variable_2="q6_init"/>
        <map_variables variable_1="q_0_Pi" variable_2="q7_init"/>
        <map_variables variable_1="q_0_PE_o" variable_2="q8_init"/>
        <map_variables variable_1="q_0_PE2K_o" variable_2="q9_init"/>
        <map_variables variable_1="q_0_E2K_o" variable_2="q10_init"/>
        <map_variables variable_1="q_0_ATPE2K_o" variable_2="q11_init"/>
        <map_variables variable_1="q_0_ATPE2K_i" variable_2="q12_init"/>
        <map_variables variable_1="q_0_ATPE_i" variable_2="q13_init"/>
        <map_variables variable_1="q_0_ATPE3Na_i" variable_2="q14_init"/>
        <map_variables variable_1="q_0_PE3Na_i" variable_2="q15_init"/>
        <map_variables variable_1="q_0_PE3Na_o" variable_2="q16_init"/>
        <map_variables variable_1="q_0_E" variable_2="q_E_init"/>
        <map_variables variable_1="q_Na_o" variable_2="q1"/>
        <map_variables variable_1="q_Na_i" variable_2="q2"/>
        <map_variables variable_1="q_K_o" variable_2="q3"/>
        <map_variables variable_1="q_K_i" variable_2="q4"/>
        <map_variables variable_1="q_ATP" variable_2="q5"/>
        <map_variables variable_1="q_ADP" variable_2="q6"/>
        <map_variables variable_1="q_Pi" variable_2="q7"/>
        <map_variables variable_1="q_PE_o" variable_2="q8"/>
        <map_variables variable_1="q_PE2K_o" variable_2="q9"/>
        <map_variables variable_1="q_E2K_o" variable_2="q10"/>
        <map_variables variable_1="q_ATPE2K_o" variable_2="q11"/>
        <map_variables variable_1="q_ATPE2K_i" variable_2="q12"/>
        <map_variables variable_1="q_ATPE_i" variable_2="q13"/>
        <map_variables variable_1="q_ATPE3Na_i" variable_2="q14"/>
        <map_variables variable_1="q_PE3Na_i" variable_2="q15"/>
        <map_variables variable_1="q_PE3Na_o" variable_2="q16"/>
        <map_variables variable_1="q_E" variable_2="q_E"/>
        <map_variables variable_1="v_Re1" variable_2="v_Re1"/>
        <map_variables variable_1="v_Re2" variable_2="v_Re2"/>
        <map_variables variable_1="v_Re3" variable_2="v_Re3"/>
        <map_variables variable_1="v_Re4" variable_2="v_Re4"/>
        <map_variables variable_1="v_Re5" variable_2="v_Re5"/>
        <map_variables variable_1="v_Re6" variable_2="v_Re6"/>
        <map_variables variable_1="v_Re7" variable_2="v_Re7"/>
        <map_variables variable_1="v_Re8" variable_2="v_Re8"/>
        <map_variables variable_1="v_Re9" variable_2="v_Re9"/>
        <map_variables variable_1="u_Na_o" variable_2="u1"/>
        <map_variables variable_1="u_Na_i" variable_2="u2"/>
        <map_variables variable_1="u_K_o" variable_2="u3"/>
        <map_variables variable_1="u_K_i" variable_2="u4"/>
        <map_variables variable_1="u_ATP" variable_2="u5"/>
        <map_variables variable_1="u_ADP" variable_2="u6"/>
        <map_variables variable_1="u_Pi" variable_2="u7"/>
        <map_variables variable_1="u_PE_o" variable_2="u8"/>
        <map_variables variable_1="u_PE2K_o" variable_2="u9"/>
        <map_variables variable_1="u_E2K_o" variable_2="u10"/>
        <map_variables variable_1="u_ATPE2K_o" variable_2="u11"/>
        <map_variables variable_1="u_ATPE2K_i" variable_2="u12"/>
        <map_variables variable_1="u_ATPE_i" variable_2="u13"/>
        <map_variables variable_1="u_ATPE3Na_i" variable_2="u14"/>
        <map_variables variable_1="u_PE3Na_i" variable_2="u15"/>
        <map_variables variable_1="u_PE3Na_o" variable_2="u16"/>
        <map_variables variable_1="u17" variable_2="u17"/>
        <map_variables variable_1="u18" variable_2="u18"/>
        <map_variables variable_1="u19" variable_2="u19"/>
        <map_variables variable_1="u20" variable_2="u20"/>
        <map_variables variable_1="u21" variable_2="u21"/>
        <map_variables variable_1="u22" variable_2="u22"/>
        <map_variables variable_1="u23" variable_2="u23"/>
        <map_variables variable_1="u24" variable_2="u24"/>
        <map_variables variable_1="u_E" variable_2="u_E"/>
    </connection>
    <!-- Mapping to the Parameters module-->
    <connection>
        <map_components component_1="param" component_2="state"/>
        <map_variables variable_1="K_Na_o" variable_2="K_q1"/>
        <map_variables variable_1="K_Na_i" variable_2="K_q2"/>
        <map_variables variable_1="K_K_o" variable_2="K_q3"/>
        <map_variables variable_1="K_K_i" variable_2="K_q4"/>
        <map_variables variable_1="K_ATP" variable_2="K_q5"/>
        <map_variables variable_1="K_ADP" variable_2="K_q6"/>
        <map_variables variable_1="K_Pi" variable_2="K_q7"/>
        <map_variables variable_1="K_PE_o" variable_2="K_q8"/>
        <map_variables variable_1="K_PE2K_o" variable_2="K_q9"/>
        <map_variables variable_1="K_E2K_o" variable_2="K_q10"/>
        <map_variables variable_1="K_ATPE2K_o" variable_2="K_q11"/>
        <map_variables variable_1="K_ATPE2K_i" variable_2="K_q12"/>
        <map_variables variable_1="K_ATPE_i" variable_2="K_q13"/>
        <map_variables variable_1="K_ATPE3Na_i" variable_2="K_q14"/>
        <map_variables variable_1="K_PE3Na_i" variable_2="K_q15"/>
        <map_variables variable_1="K_PE3Na_o" variable_2="K_q16"/>
        <map_variables variable_1="K_E" variable_2="K_E"/>
        <map_variables variable_1="K_Re1" variable_2="K_Re1"/>
        <map_variables variable_1="K_Re2" variable_2="K_Re2"/>
        <map_variables variable_1="K_Re3" variable_2="K_Re3"/>
        <map_variables variable_1="K_Re4" variable_2="K_Re4"/>
        <map_variables variable_1="K_Re5" variable_2="K_Re5"/>
        <map_variables variable_1="K_Re6" variable_2="K_Re6"/>
        <map_variables variable_1="K_Re7" variable_2="K_Re7"/>
        <map_variables variable_1="K_Re8" variable_2="K_Re8"/>
        <map_variables variable_1="K_Re9" variable_2="K_Re9"/>
    </connection>
    <group>
        <relationship_ref relationship="encapsulation"/>
        <component_ref component="module">
            <component_ref component="state"/>
            <component_ref component="param"/>
        </component_ref>
    </group>
</model>