- Author:
- Soroush Safaei <ssaf006@aucklanduni.ac.nz>
- Date:
- 2016-07-20 19:00:18+12:00
- Desc:
- update units
- Permanent Source URI:
- https://models.physiomeproject.org/workspace/293/rawfile/7b86a24bb68a728fc430de1f9219e79d9d8590a5/Weinstein_2000_HATPase.cellml
<?xml version='1.0'?>
<!-- This CellML file was generated from:
Weinstein, Alan M. "A mathematical model of the outer medullary collecting duct of the rat." American Journal of Physiology-Renal Physiology 279.1 (2000): F24-F45.
The results are compared with Figure 6 in:
Chang, Hangil, and Toshiro Fujita. "A numerical model of acid-base transport in rat distal tubule." American Journal of Physiology-Renal Physiology 281.2 (2001): F222-F243.
If J_Vtype_H>0 then the flux direction is from intracellular space to extracellular space. (always [C_int]-J and [C_ext]+J)-->
<model cmeta:id="Weinstein_2000_HATPase" name="Weinstein_2000_HATPase" xmlns="http://www.cellml.org/cellml/1.1#" xmlns:cellml="http://www.cellml.org/cellml/1.1#" xmlns:cmeta="http://www.cellml.org/metadata/1.0#" xmlns:xlink="http://www.w3.org/1999/xlink">
<import xlink:href="Units/Units.cellml">
<units name="mJ_per_mol" units_ref="mJ_per_mol"/>
<units name="mol_per_mJ" units_ref="mol_per_mJ"/>
<units name="mV" units_ref="mV"/>
<units name="mM" units_ref="mM"/>
<units name="C_per_mol" units_ref="C_per_mol"/>
<units name="mJ_per_mol_per_kelvin" units_ref="mJ_per_mol_per_kelvin"/>
<units name="umol_per_s_per_cm2" units_ref="umol_per_s_per_cm2"/>
</import>
<component name="H_ATPase">
<variable name="psi" public_interface="in" units="mV"/>
<variable name="H_int" public_interface="in" units="mM"/>
<variable name="H_ext" public_interface="in" units="mM"/>
<variable name="mu_H" units="mJ_per_mol"/>
<variable initial_value="2.1e-6" name="mu_0" units="mJ_per_mol"/>
<variable initial_value="0.4e-6" name="xi" units="mol_per_mJ"/>
<variable initial_value="96485" name="F" units="C_per_mol"/>
<variable initial_value="8314.41" name="R" units="mJ_per_mol_per_kelvin"/>
<variable initial_value="300" name="T" units="kelvin"/>
<variable initial_value="-1.57" name="z" units="dimensionless"/>
<variable initial_value="0.0018" name="J_Vtype_H_Max" public_interface="out" units="umol_per_s_per_cm2"/>
<variable name="J_Vtype_H" public_interface="out" units="umol_per_s_per_cm2"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply id="electrochemical_potential_difference_calculation">
<eq/>
<ci>mu_H</ci>
<apply>
<plus/>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
<apply>
<ln/>
<apply>
<divide/>
<ci>H_ext</ci>
<ci>H_int</ci>
</apply>
</apply>
</apply>
<apply>
<times/>
<ci>z</ci>
<ci>F</ci>
<ci>psi</ci>
</apply>
</apply>
</apply>
<apply id="H_flux">
<eq/>
<ci>J_Vtype_H</ci>
<apply>
<divide/>
<ci>J_Vtype_H_Max</ci>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<times/>
<ci>xi</ci>
<apply>
<minus/>
<ci>mu_H</ci>
<ci>mu_0</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="">
<dc:title xmlns:dc="http://purl.org/dc/elements/1.1/">A kinetic model of V-type H+-ATPase (proton pump)</dc:title>
</rdf:Description>
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<dc:title xmlns:dc="http://purl.org/dc/elements/1.1/">A kinetic model of V-type H+-ATPase (proton pump)</dc:title>
</rdf:Description>
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</model>
