- Author:
- Amr Al Abed <amra@unsw.edu.au>
- Date:
- 2017-06-16 22:07:22+10:00
- Desc:
- Converted encoding to UTF-8
- Permanent Source URI:
- https://models.physiomeproject.org/workspace/28b/rawfile/2105a486f14159db17520e1830b3a2e1d3ad2acf/AlAbed_2013_pSAN_model/leakage_current.cellml
<?xml version='1.0'?>
<!--Author: Amr Al Abed
Date: 12/02/2016
Leakage ionic current based on the formulation of Al Abed et al 2013 for a peripheral sino-atrial node cell-->
<!--metadata-->
<model name="leakage_ion" cmeta:id="leakage_ion" xmlns="http://www.cellml.org/cellml/1.1#" xmlns:cellml="http://www.cellml.org/cellml/1.1#" xmlns:cmeta="http://www.cellml.org/metadata/1.0#">
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bqs="http://www.cellml.org/bqs/1.0#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#">
<rdf:Description rdf:about="#leakage_ion">
<bqs:reference rdf:parseType="Resource">
<dc:subject rdf:parseType="Resource">
<bqs:subject_type>keyword</bqs:subject_type>
<rdf:value>
<rdf:Bag>
<rdf:li>electrophysiology</rdf:li>
<rdf:li>cardiac</rdf:li>
<rdf:li>cardiac electrophysiology</rdf:li>
<rdf:li>pacemaker</rdf:li>
<rdf:li>sinus node</rdf:li>
</rdf:Bag>
</rdf:value>
</dc:subject>
</bqs:reference>
</rdf:Description>
</rdf:RDF>
<!--Define units-->
<units name="millivolt">
<unit prefix="milli" units="volt"/>
</units>
<units name="nanoA_per_cm2">
<unit prefix="nano" units="ampere"/>
<unit exponent="-2" prefix="centi" units="metre"/>
</units>
<units name="microS_per_cm2">
<unit prefix="micro" units="siemens"/>
<unit exponent="-2" prefix="centi" units="metre"/>
</units>
<!--Define simulation environment-->
<component name="environment">
<variable initial_value="0" name="V" public_interface="out" units="millivolt"/>
<variable name="t" public_interface="out" units="millisec"/>
</component>
<!--Define mapping-->
<connection>
<map_components component_1="leakage_channel" component_2="environment"/>
<map_variables variable_1="V" variable_2="V"/>
</connection>
<!--Define ion current-->
<component name="leakage_channel">
<variable name="V" public_interface="in" units="millivolt"/>
<variable name="i_L" public_interface="out" units="nanoA_per_cm2"/>
<variable initial_value="16.047" name="g_L" units="microS_per_cm2"/>
<variable initial_value="-71.67" name="E_L" units="millivolt"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>i_L</ci>
<apply>
<times/>
<ci>g_L</ci>
<apply>
<minus/>
<ci>V</ci>
<ci>E_L</ci>
</apply>
</apply>
</apply>
</math>
</component>
</model>
