- Author:
- David Nickerson <nickerso@users.sourceforge.net>
- Date:
- 2016-01-18 11:55:52+13:00
- Desc:
- correct reST formatting
- Permanent Source URI:
- https://models.physiomeproject.org/workspace/285/rawfile/2a10a6a1fb003356b75b4d8f22fe77a56c4e98f4/Sham_AB_models/Gattoni_SHAM1Hz.cellml
<?xml version="1.0" encoding="utf-8"?>
<!--
This CellML file was generated on 29/05/2015 at 15:37:07 using:
COR (0.9.31.1409)
Copyright 2002-2015 Dr Alan Garny
http://cor.physiol.ox.ac.uk/ - cor@physiol.ox.ac.uk
CellML 1.0 was used to generate this model
http://www.cellml.org/
-->
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<cn cellml:units="dimensionless">98.9</cn>
<apply>
<exp/>
<apply>
<times/>
<apply>
<minus/>
<cn cellml:units="per_mV">0.1</cn>
</apply>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="mV">38</cn>
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</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
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<ci>time</ci>
</bvar>
<ci>r</ci>
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<apply>
<divide/>
<apply>
<minus/>
<ci>r_infinity</ci>
<ci>r</ci>
</apply>
<ci>tau_r</ci>
</apply>
</apply>
</math>
</component>
<component name="Ca_independent_transient_outward_K_current_s_gate">
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<variable name="tau_s" units="ms"/>
<variable name="s_infinity" units="dimensionless"/>
<variable name="V" units="mV" public_interface="in"/>
<variable name="time" units="ms" public_interface="in"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>s_infinity</ci>
<apply>
<divide/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
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<apply>
<divide/>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="mV">45.3</cn>
</apply>
<cn cellml:units="mV">6.8841</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>tau_s</ci>
<apply>
<plus/>
<apply>
<times/>
<cn cellml:units="ms">20</cn>
<apply>
<exp/>
<apply>
<minus/>
<apply>
<power/>
<apply>
<divide/>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="mV">70</cn>
</apply>
<cn cellml:units="mV">25</cn>
</apply>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
</apply>
<cn cellml:units="ms">35</cn>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>s</ci>
</apply>
<apply>
<divide/>
<apply>
<minus/>
<ci>s_infinity</ci>
<ci>s</ci>
</apply>
<ci>tau_s</ci>
</apply>
</apply>
</math>
</component>
<component name="Ca_independent_transient_outward_K_current_s_slow_gate">
<variable name="s_slow" units="dimensionless" initial_value="0.78841193673441" public_interface="out"/>
<variable name="tau_s_slow" units="ms"/>
<variable name="s_slow_infinity" units="dimensionless"/>
<variable name="V" units="mV" public_interface="in"/>
<variable name="time" units="ms" public_interface="in"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>s_slow_infinity</ci>
<apply>
<divide/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<plus/>
<ci>V</ci>
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<cn cellml:units="mV">6.8841</cn>
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</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>tau_s_slow</ci>
<apply>
<plus/>
<apply>
<times/>
<cn cellml:units="ms">1300</cn>
<apply>
<exp/>
<apply>
<minus/>
<apply>
<power/>
<apply>
<divide/>
<apply>
<plus/>
<ci>V</ci>
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<cn cellml:units="mV">30</cn>
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<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
</apply>
<cn cellml:units="ms">35</cn>
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<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>s_slow</ci>
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<apply>
<divide/>
<apply>
<minus/>
<ci>s_slow_infinity</ci>
<ci>s_slow</ci>
</apply>
<ci>tau_s_slow</ci>
</apply>
</apply>
</math>
</component>
<component name="steady_state_outward_K_current">
<variable name="i_ss" units="uA" public_interface="out"/>
<variable name="g_ss" units="mSi" initial_value="1.3e-5"/>
<variable name="time" units="ms" public_interface="in" private_interface="out"/>
<variable name="V" units="mV" public_interface="in" private_interface="out"/>
<variable name="E_K" units="mV" public_interface="in"/>
<variable name="r_ss" units="dimensionless" private_interface="in"/>
<variable name="s_ss" units="dimensionless" private_interface="in"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>i_ss</ci>
<apply>
<times/>
<ci>g_ss</ci>
<ci>r_ss</ci>
<ci>s_ss</ci>
<apply>
<minus/>
<ci>V</ci>
<ci>E_K</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="steady_state_outward_K_current_r_ss_gate">
<variable name="r_ss" units="dimensionless" initial_value="0.0019683140031203" public_interface="out"/>
<variable name="tau_r_ss" units="ms"/>
<variable name="r_ss_infinity" units="dimensionless"/>
<variable name="V" units="mV" public_interface="in"/>
<variable name="time" units="ms" public_interface="in"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>r_ss_infinity</ci>
<apply>
<divide/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="mV">11.5</cn>
</apply>
<apply>
<minus/>
<cn cellml:units="mV">11.82</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>tau_r_ss</ci>
<apply>
<divide/>
<cn cellml:units="ms">10000</cn>
<apply>
<plus/>
<apply>
<times/>
<cn cellml:units="dimensionless">45.16</cn>
<apply>
<exp/>
<apply>
<times/>
<cn cellml:units="per_mV">0.03577</cn>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="mV">50</cn>
</apply>
</apply>
</apply>
</apply>
<apply>
<times/>
<cn cellml:units="dimensionless">98.9</cn>
<apply>
<exp/>
<apply>
<times/>
<apply>
<minus/>
<cn cellml:units="per_mV">0.1</cn>
</apply>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="mV">38</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>r_ss</ci>
</apply>
<apply>
<divide/>
<apply>
<minus/>
<ci>r_ss_infinity</ci>
<ci>r_ss</ci>
</apply>
<ci>tau_r_ss</ci>
</apply>
</apply>
</math>
</component>
<component name="steady_state_outward_K_current_s_ss_gate">
<variable name="s_ss" units="dimensionless" initial_value="0.416987850222633" public_interface="out"/>
<variable name="tau_s_ss" units="ms"/>
<variable name="s_ss_infinity" units="dimensionless"/>
<variable name="V" units="mV" public_interface="in"/>
<variable name="time" units="ms" public_interface="in"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>s_ss_infinity</ci>
<apply>
<divide/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="mV">87.5</cn>
</apply>
<cn cellml:units="mV">10.3</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>tau_s_ss</ci>
<cn cellml:units="ms">2100</cn>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>s_ss</ci>
</apply>
<apply>
<divide/>
<apply>
<minus/>
<ci>s_ss_infinity</ci>
<ci>s_ss</ci>
</apply>
<ci>tau_s_ss</ci>
</apply>
</apply>
</math>
</component>
<component name="inward_rectifier">
<variable name="i_K1" units="uA" public_interface="out"/>
<variable name="g_K1" units="mSi" initial_value="4e-5"/>
<variable name="V" units="mV" public_interface="in"/>
<variable name="R" units="millijoule_per_mole_kelvin" public_interface="in"/>
<variable name="F" units="coulomb_per_mole" public_interface="in"/>
<variable name="T" units="kelvin" public_interface="in"/>
<variable name="K_o" units="mM" public_interface="in"/>
<variable name="K_i" units="mM" public_interface="in"/>
<variable name="E_K" units="mV" public_interface="in"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>i_K1</ci>
<apply>
<plus/>
<apply>
<divide/>
<apply>
<times/>
<apply>
<plus/>
<apply>
<divide/>
<cn cellml:units="uA">0.048</cn>
<apply>
<plus/>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="mV">37</cn>
</apply>
<cn cellml:units="mV">25</cn>
</apply>
</apply>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="mV">37</cn>
</apply>
<apply>
<minus/>
<cn cellml:units="mV">25</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<cn cellml:units="uA">0.01</cn>
</apply>
<cn cellml:units="dimensionless">0.001</cn>
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<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<ci>V</ci>
<apply>
<plus/>
<ci>E_K</ci>
<cn cellml:units="mV">76.77</cn>
</apply>
</apply>
<apply>
<minus/>
<cn cellml:units="mV">17</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>g_K1</ci>
<apply>
<minus/>
<ci>V</ci>
<apply>
<plus/>
<ci>E_K</ci>
<cn cellml:units="mV">1.73</cn>
</apply>
</apply>
</apply>
<apply>
<times/>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<times/>
<cn cellml:units="dimensionless">1.613</cn>
<ci>F</ci>
<apply>
<minus/>
<ci>V</ci>
<apply>
<plus/>
<ci>E_K</ci>
<cn cellml:units="mV">1.73</cn>
</apply>
</apply>
</apply>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<ci>K_o</ci>
<cn cellml:units="mM">0.9988</cn>
</apply>
<apply>
<minus/>
<cn cellml:units="mM">0.124</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="hyperpolarisation_activated_current">
<variable name="i_f" units="uA" public_interface="out"/>
<variable name="i_f_Na" units="uA" public_interface="out"/>
<variable name="i_f_K" units="uA" public_interface="out"/>
<variable name="g_f" units="mSi" initial_value="1.45e-6"/>
<variable name="f_Na" units="dimensionless" initial_value="0.2"/>
<variable name="f_K" units="dimensionless"/>
<variable name="time" units="ms" public_interface="in" private_interface="out"/>
<variable name="V" units="mV" public_interface="in" private_interface="out"/>
<variable name="E_K" units="mV" public_interface="in"/>
<variable name="E_Na" units="mV" public_interface="in"/>
<variable name="y" units="dimensionless" private_interface="in"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>f_K</ci>
<apply>
<minus/>
<cn cellml:units="dimensionless">1</cn>
<ci>f_Na</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>i_f_Na</ci>
<apply>
<times/>
<ci>g_f</ci>
<ci>y</ci>
<ci>f_Na</ci>
<apply>
<minus/>
<ci>V</ci>
<ci>E_Na</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>i_f_K</ci>
<apply>
<times/>
<ci>g_f</ci>
<ci>y</ci>
<ci>f_K</ci>
<apply>
<minus/>
<ci>V</ci>
<ci>E_K</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>i_f</ci>
<apply>
<plus/>
<ci>i_f_Na</ci>
<ci>i_f_K</ci>
</apply>
</apply>
</math>
</component>
<component name="hyperpolarisation_activated_current_y_gate">
<variable name="y" units="dimensionless" initial_value="0.00566123148325894" public_interface="out"/>
<variable name="tau_y" units="ms"/>
<variable name="y_infinity" units="dimensionless"/>
<variable name="V" units="mV" public_interface="in"/>
<variable name="time" units="ms" public_interface="in"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>y_infinity</ci>
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<divide/>
<cn cellml:units="dimensionless">1</cn>
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<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="mV">138.6</cn>
</apply>
<cn cellml:units="mV">10.48</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>tau_y</ci>
<apply>
<divide/>
<cn cellml:units="ms">1000</cn>
<apply>
<plus/>
<apply>
<times/>
<cn cellml:units="dimensionless">0.11885</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="mV">80</cn>
</apply>
<cn cellml:units="mV">28.37</cn>
</apply>
</apply>
</apply>
<apply>
<times/>
<cn cellml:units="dimensionless">0.5623</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="mV">80</cn>
</apply>
<apply>
<minus/>
<cn cellml:units="mV">14.19</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>y</ci>
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<apply>
<divide/>
<apply>
<minus/>
<ci>y_infinity</ci>
<ci>y</ci>
</apply>
<ci>tau_y</ci>
</apply>
</apply>
</math>
</component>
<component name="background_currents">
<variable name="i_B" units="uA" public_interface="out"/>
<variable name="i_B_Na" units="uA" public_interface="out"/>
<variable name="i_B_K" units="uA" public_interface="out"/>
<variable name="g_B_Na" units="mSi" initial_value="8.015e-8"/>
<variable name="g_B_K" units="mSi" initial_value="1.38e-7"/>
<variable name="E_Na" units="mV" public_interface="in"/>
<variable name="E_K" units="mV" public_interface="in"/>
<variable name="V" units="mV" public_interface="in"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>i_B_Na</ci>
<apply>
<times/>
<ci>g_B_Na</ci>
<apply>
<minus/>
<ci>V</ci>
<ci>E_Na</ci>
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</apply>
</apply>
<apply>
<eq/>
<ci>i_B_K</ci>
<apply>
<times/>
<ci>g_B_K</ci>
<apply>
<minus/>
<ci>V</ci>
<ci>E_K</ci>
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</apply>
</apply>
<apply>
<eq/>
<ci>i_B</ci>
<apply>
<plus/>
<ci>i_B_Na</ci>
<ci>i_B_K</ci>
</apply>
</apply>
</math>
</component>
<component name="sodium_potassium_pump">
<variable name="i_NaK" units="uA" public_interface="out"/>
<variable name="i_NaK_max" units="uA" initial_value="0.00138"/>
<variable name="nu_1" units="dimensionless"/>
<variable name="gamma1" units="dimensionless" initial_value="3.6"/>
<variable name="KdNaio" units="mM" initial_value="19"/>
<variable name="KdNais" units="mM" initial_value="22"/>
<variable name="KdNaes" units="mM" initial_value="880"/>
<variable name="Delta" units="dimensionless" initial_value="0.3"/>
<variable name="alpha" units="mM" initial_value="1.8"/>
<variable name="K_o" units="mM" public_interface="in"/>
<variable name="Na_o" units="mM" public_interface="in"/>
<variable name="Na_i" units="mM" public_interface="in"/>
<variable name="R" units="millijoule_per_mole_kelvin" public_interface="in"/>
<variable name="F" units="coulomb_per_mole" public_interface="in"/>
<variable name="T" units="kelvin" public_interface="in"/>
<variable name="V" units="mV" public_interface="in"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>nu_1</ci>
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<plus/>
<apply>
<times/>
<ci>gamma1</ci>
<apply>
<power/>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>KdNaio</ci>
<ci>Na_i</ci>
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</apply>
<cn cellml:units="dimensionless">2</cn>
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<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<times/>
<apply>
<divide/>
<ci>KdNais</ci>
<ci>Na_i</ci>
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<apply>
<exp/>
<apply>
<divide/>
<apply>
<divide/>
<apply>
<times/>
<apply>
<minus/>
<ci>Delta</ci>
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<ci>F</ci>
<ci>V</ci>
</apply>
<ci>R</ci>
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<ci>T</ci>
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</apply>
</apply>
</apply>
</apply>
<apply>
<times/>
<apply>
<power/>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>alpha</ci>
<ci>K_o</ci>
</apply>
</apply>
<cn cellml:units="dimensionless">2</cn>
</apply>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<times/>
<apply>
<divide/>
<ci>Na_o</ci>
<ci>KdNaes</ci>
</apply>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<divide/>
<apply>
<times/>
<apply>
<minus/>
<apply>
<minus/>
<cn cellml:units="dimensionless">1</cn>
<ci>Delta</ci>
</apply>
</apply>
<ci>F</ci>
<ci>V</ci>
</apply>
<ci>R</ci>
</apply>
<ci>T</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>i_NaK</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>i_NaK_max</ci>
<apply>
<plus/>
<ci>gamma1</ci>
<cn cellml:units="dimensionless">1</cn>
</apply>
</apply>
<ci>nu_1</ci>
</apply>
</apply>
</math>
</component>
<component name="extracellular_ion_concentrations">
<variable name="K_o" units="mM" initial_value="5.4" public_interface="out"/>
<variable name="Na_o" units="mM" initial_value="140" public_interface="out"/>
<variable name="Ca_o" units="mM" initial_value="1.8" public_interface="out"/>
</component>
<component name="CaRU">
<variable name="g_D" units="um3_per_ms" initial_value="0.1" private_interface="out"/>
<variable name="J_R" units="um3_per_ms" initial_value="0.02" private_interface="out"/>
<variable name="J_L" units="um3_per_ms" initial_value="0.0008" private_interface="out"/>
<variable name="Vmyo" units="um3" public_interface="in" private_interface="out"/>
<variable name="Vmyo_uL" units="uL" public_interface="in" private_interface="out"/>
<variable name="N" units="dimensionless" initial_value="50000" private_interface="out"/>
<variable name="V" units="mV" public_interface="in" private_interface="out"/>
<variable name="Ca_i" units="mM" public_interface="in" private_interface="out"/>
<variable name="Ca_o" units="mM" public_interface="in" private_interface="out"/>
<variable name="Ca_SR" units="mM" public_interface="in" private_interface="out"/>
<variable name="time" units="ms" public_interface="in" private_interface="out"/>
<variable name="F" units="coulomb_per_mole" public_interface="in" private_interface="out"/>
<variable name="FVRT_Ca" units="dimensionless" public_interface="in" private_interface="out"/>
<variable name="i_RyR2" units="mM_per_ms" public_interface="out" private_interface="in"/>
<variable name="i_LCC2" units="uA" public_interface="out" private_interface="in"/>
</component>
<component name="CaRU_Transitions">
<variable name="V" units="mV" public_interface="in"/>
<variable name="C_oc" units="mM" public_interface="in"/>
<variable name="C_co" units="mM" public_interface="in"/>
<variable name="Ca_i" units="mM" public_interface="in"/>
<variable name="V_L" units="mV" initial_value="-9"/>
<variable name="del_VL" units="mV" initial_value="7"/>
<variable name="phi_L" units="dimensionless" initial_value="11.5"/>
<variable name="t_L" units="ms" initial_value="1"/>
<variable name="tau_L" units="ms" initial_value="1550"/>
<variable name="t_R" units="ms" initial_value="1.17"/>
<variable name="tau_R" units="ms" initial_value="2.4"/>
<variable name="phi_R" units="dimensionless" initial_value="0.05"/>
<variable name="theta_R" units="dimensionless" initial_value="0.012"/>
<variable name="K_RyR" units="mM" initial_value="0.065"/>
<variable name="K_L" units="mM" initial_value="0.00038"/>
<variable name="a1" units="dimensionless" initial_value="0.0625"/>
<variable name="b1" units="dimensionless" initial_value="14"/>
<variable name="c" units="dimensionless" initial_value="0.01"/>
<variable name="d" units="dimensionless" initial_value="100"/>
<variable name="expVL" units="dimensionless"/>
<variable name="alpha_p" units="per_ms" public_interface="out"/>
<variable name="alpha_m" units="per_ms" public_interface="out"/>
<variable name="beta_poc" units="per_ms" public_interface="out"/>
<variable name="beta_pcc" units="per_ms" public_interface="out"/>
<variable name="beta_m" units="per_ms" public_interface="out"/>
<variable name="epsilon_pco" units="per_ms" public_interface="out"/>
<variable name="epsilon_pcc" units="per_ms" public_interface="out"/>
<variable name="epsilon_m" units="per_ms" public_interface="out"/>
<variable name="mu_poc" units="per_ms" public_interface="out"/>
<variable name="mu_pcc" units="per_ms" public_interface="out"/>
<variable name="mu_moc" units="per_ms" public_interface="out"/>
<variable name="mu_mcc" units="per_ms" public_interface="out"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>expVL</ci>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<ci>V</ci>
<ci>V_L</ci>
</apply>
<ci>del_VL</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>alpha_p</ci>
<apply>
<divide/>
<ci>expVL</ci>
<apply>
<times/>
<ci>t_L</ci>
<apply>
<plus/>
<ci>expVL</ci>
<cn cellml:units="dimensionless">1</cn>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>alpha_m</ci>
<apply>
<divide/>
<ci>phi_L</ci>
<ci>t_L</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>beta_poc</ci>
<apply>
<divide/>
<apply>
<power/>
<ci>C_oc</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
<apply>
<times/>
<ci>t_R</ci>
<apply>
<plus/>
<apply>
<power/>
<ci>C_oc</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
<apply>
<power/>
<ci>K_RyR</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>beta_pcc</ci>
<apply>
<divide/>
<apply>
<power/>
<ci>Ca_i</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
<apply>
<times/>
<ci>t_R</ci>
<apply>
<plus/>
<apply>
<power/>
<ci>Ca_i</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
<apply>
<power/>
<ci>K_RyR</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>beta_m</ci>
<apply>
<divide/>
<ci>phi_R</ci>
<ci>t_R</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>epsilon_pco</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>C_co</ci>
<apply>
<plus/>
<ci>expVL</ci>
<ci>a1</ci>
</apply>
</apply>
<apply>
<times/>
<ci>tau_L</ci>
<ci>K_L</ci>
<apply>
<plus/>
<ci>expVL</ci>
<cn cellml:units="dimensionless">1</cn>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>epsilon_pcc</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>Ca_i</ci>
<apply>
<plus/>
<ci>expVL</ci>
<ci>a1</ci>
</apply>
</apply>
<apply>
<times/>
<ci>tau_L</ci>
<ci>K_L</ci>
<apply>
<plus/>
<ci>expVL</ci>
<cn cellml:units="dimensionless">1</cn>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>epsilon_m</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>b1</ci>
<apply>
<plus/>
<ci>expVL</ci>
<ci>a1</ci>
</apply>
</apply>
<apply>
<times/>
<ci>tau_L</ci>
<apply>
<plus/>
<apply>
<times/>
<ci>b1</ci>
<ci>expVL</ci>
</apply>
<ci>a1</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>mu_poc</ci>
<apply>
<divide/>
<apply>
<plus/>
<apply>
<power/>
<ci>C_oc</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
<apply>
<times/>
<ci>c</ci>
<apply>
<power/>
<ci>K_RyR</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
<apply>
<times/>
<ci>tau_R</ci>
<apply>
<plus/>
<apply>
<power/>
<ci>C_oc</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
<apply>
<power/>
<ci>K_RyR</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>mu_pcc</ci>
<apply>
<divide/>
<apply>
<plus/>
<apply>
<power/>
<ci>Ca_i</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
<apply>
<times/>
<ci>c</ci>
<apply>
<power/>
<ci>K_RyR</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
<apply>
<times/>
<ci>tau_R</ci>
<apply>
<plus/>
<apply>
<power/>
<ci>Ca_i</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
<apply>
<power/>
<ci>K_RyR</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>mu_moc</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>theta_R</ci>
<ci>d</ci>
<apply>
<plus/>
<apply>
<power/>
<ci>C_oc</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
<apply>
<times/>
<ci>c</ci>
<apply>
<power/>
<ci>K_RyR</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
</apply>
<apply>
<times/>
<ci>tau_R</ci>
<apply>
<plus/>
<apply>
<times/>
<ci>d</ci>
<apply>
<power/>
<ci>C_oc</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
<apply>
<times/>
<ci>c</ci>
<apply>
<power/>
<ci>K_RyR</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>mu_mcc</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>theta_R</ci>
<ci>d</ci>
<apply>
<plus/>
<apply>
<power/>
<ci>Ca_i</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
<apply>
<times/>
<ci>c</ci>
<apply>
<power/>
<ci>K_RyR</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
</apply>
<apply>
<times/>
<ci>tau_R</ci>
<apply>
<plus/>
<apply>
<times/>
<ci>d</ci>
<apply>
<power/>
<ci>Ca_i</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
<apply>
<times/>
<ci>c</ci>
<apply>
<power/>
<ci>K_RyR</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="DS_Calcium_Concentrations">
<variable name="Ca_i" units="mM" public_interface="in"/>
<variable name="Ca_SR" units="mM" public_interface="in"/>
<variable name="Ca_o" units="mM" public_interface="in"/>
<variable name="FVRT_Ca" units="dimensionless" public_interface="in"/>
<variable name="g_D" units="um3_per_ms" public_interface="in"/>
<variable name="J_R" units="um3_per_ms" public_interface="in"/>
<variable name="J_L" units="um3_per_ms" public_interface="in"/>
<variable name="C_cc" units="mM" public_interface="out"/>
<variable name="C_oc" units="mM" public_interface="out"/>
<variable name="C_co" units="mM" public_interface="out"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>C_cc</ci>
<ci>Ca_i</ci>
</apply>
<apply>
<eq/>
<ci>C_co</ci>
<apply>
<divide/>
<apply>
<plus/>
<ci>Ca_i</ci>
<apply>
<times/>
<apply>
<divide/>
<ci>J_R</ci>
<ci>g_D</ci>
</apply>
<ci>Ca_SR</ci>
</apply>
</apply>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>J_R</ci>
<ci>g_D</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>C_oc</ci>
<piecewise>
<piece>
<apply>
<divide/>
<apply>
<plus/>
<ci>Ca_i</ci>
<apply>
<divide/>
<apply>
<times/>
<apply>
<divide/>
<ci>J_L</ci>
<ci>g_D</ci>
</apply>
<ci>Ca_o</ci>
<ci>FVRT_Ca</ci>
<apply>
<exp/>
<apply>
<minus/>
<ci>FVRT_Ca</ci>
</apply>
</apply>
</apply>
<apply>
<minus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<minus/>
<ci>FVRT_Ca</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<apply>
<times/>
<apply>
<divide/>
<ci>J_L</ci>
<ci>g_D</ci>
</apply>
<ci>FVRT_Ca</ci>
</apply>
<apply>
<minus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<minus/>
<ci>FVRT_Ca</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<gt/>
<apply>
<abs/>
<ci>FVRT_Ca</ci>
</apply>
<cn cellml:units="dimensionless">0.000000001</cn>
</apply>
</piece>
<otherwise>
<apply>
<divide/>
<apply>
<plus/>
<ci>Ca_i</ci>
<apply>
<times/>
<apply>
<divide/>
<ci>J_L</ci>
<ci>g_D</ci>
</apply>
<ci>Ca_o</ci>
</apply>
</apply>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>J_L</ci>
<ci>g_D</ci>
</apply>
</apply>
</apply>
</otherwise>
</piecewise>
</apply>
</math>
</component>
<component name="LCC_and_RyR_fluxes">
<variable name="g_D" units="um3_per_ms" public_interface="in"/>
<variable name="J_R" units="um3_per_ms" public_interface="in"/>
<variable name="J_L" units="um3_per_ms" public_interface="in"/>
<variable name="Ca_i" units="mM" public_interface="in"/>
<variable name="Ca_SR" units="mM" public_interface="in"/>
<variable name="Ca_o" units="mM" public_interface="in"/>
<variable name="FVRT_Ca" units="dimensionless" public_interface="in"/>
<variable name="J_Loo" units="um3_mM_per_ms" public_interface="out"/>
<variable name="J_Loc" units="um3_mM_per_ms" public_interface="out"/>
<variable name="J_Rco" units="um3_mM_per_ms" public_interface="out"/>
<variable name="J_Roo" units="um3_mM_per_ms" public_interface="out"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>J_Rco</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>J_R</ci>
<apply>
<minus/>
<ci>Ca_SR</ci>
<ci>Ca_i</ci>
</apply>
</apply>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>J_R</ci>
<ci>g_D</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>J_Roo</ci>
<piecewise>
<piece>
<apply>
<divide/>
<apply>
<times/>
<ci>J_R</ci>
<apply>
<plus/>
<apply>
<minus/>
<ci>Ca_SR</ci>
<ci>Ca_i</ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<apply>
<times/>
<apply>
<divide/>
<ci>J_L</ci>
<ci>g_D</ci>
</apply>
<ci>FVRT_Ca</ci>
</apply>
<apply>
<minus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<minus/>
<ci>FVRT_Ca</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<minus/>
<ci>Ca_SR</ci>
<apply>
<times/>
<ci>Ca_o</ci>
<apply>
<exp/>
<apply>
<minus/>
<ci>FVRT_Ca</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>J_R</ci>
<ci>g_D</ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<apply>
<divide/>
<ci>J_L</ci>
<ci>g_D</ci>
</apply>
<ci>FVRT_Ca</ci>
</apply>
<apply>
<minus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<minus/>
<ci>FVRT_Ca</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<gt/>
<apply>
<abs/>
<ci>FVRT_Ca</ci>
</apply>
<cn cellml:units="dimensionless">0.00001</cn>
</apply>
</piece>
<otherwise>
<apply>
<divide/>
<apply>
<times/>
<ci>J_R</ci>
<apply>
<plus/>
<apply>
<minus/>
<ci>Ca_SR</ci>
<ci>Ca_i</ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<apply>
<times/>
<apply>
<divide/>
<ci>J_L</ci>
<ci>g_D</ci>
</apply>
<cn cellml:units="dimensionless">0.00001</cn>
</apply>
<apply>
<minus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<minus/>
<cn cellml:units="dimensionless">0.00001</cn>
</apply>
</apply>
</apply>
</apply>
<apply>
<minus/>
<ci>Ca_SR</ci>
<apply>
<times/>
<ci>Ca_o</ci>
<apply>
<exp/>
<apply>
<minus/>
<cn cellml:units="dimensionless">0.00001</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>J_R</ci>
<ci>g_D</ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<apply>
<divide/>
<ci>J_L</ci>
<ci>g_D</ci>
</apply>
<cn cellml:units="dimensionless">0.00001</cn>
</apply>
<apply>
<minus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<minus/>
<cn cellml:units="dimensionless">0.00001</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
</otherwise>
</piecewise>
</apply>
<apply>
<eq/>
<ci>J_Loc</ci>
<piecewise>
<piece>
<apply>
<divide/>
<apply>
<times/>
<apply>
<divide/>
<apply>
<times/>
<ci>J_L</ci>
<ci>FVRT_Ca</ci>
</apply>
<apply>
<minus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<minus/>
<ci>FVRT_Ca</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<minus/>
<apply>
<times/>
<ci>Ca_o</ci>
<apply>
<exp/>
<apply>
<minus/>
<ci>FVRT_Ca</ci>
</apply>
</apply>
</apply>
<ci>Ca_i</ci>
</apply>
</apply>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<apply>
<times/>
<apply>
<divide/>
<ci>J_L</ci>
<ci>g_D</ci>
</apply>
<ci>FVRT_Ca</ci>
</apply>
<apply>
<minus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<minus/>
<ci>FVRT_Ca</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<gt/>
<apply>
<abs/>
<ci>FVRT_Ca</ci>
</apply>
<cn cellml:units="dimensionless">0.00001</cn>
</apply>
</piece>
<otherwise>
<apply>
<divide/>
<apply>
<times/>
<apply>
<divide/>
<apply>
<times/>
<ci>J_L</ci>
<cn cellml:units="dimensionless">0.00001</cn>
</apply>
<apply>
<minus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<minus/>
<cn cellml:units="dimensionless">0.00001</cn>
</apply>
</apply>
</apply>
</apply>
<apply>
<minus/>
<apply>
<times/>
<ci>Ca_o</ci>
<apply>
<exp/>
<apply>
<minus/>
<cn cellml:units="dimensionless">0.00001</cn>
</apply>
</apply>
</apply>
<ci>Ca_i</ci>
</apply>
</apply>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<apply>
<times/>
<apply>
<divide/>
<ci>J_L</ci>
<ci>g_D</ci>
</apply>
<cn cellml:units="dimensionless">0.00001</cn>
</apply>
<apply>
<minus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<minus/>
<cn cellml:units="dimensionless">0.00001</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
</otherwise>
</piecewise>
</apply>
<apply>
<eq/>
<ci>J_Loo</ci>
<piecewise>
<piece>
<apply>
<divide/>
<apply>
<times/>
<apply>
<divide/>
<apply>
<times/>
<ci>J_L</ci>
<ci>FVRT_Ca</ci>
</apply>
<apply>
<minus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<minus/>
<ci>FVRT_Ca</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<plus/>
<apply>
<minus/>
<apply>
<times/>
<ci>Ca_o</ci>
<apply>
<exp/>
<apply>
<minus/>
<ci>FVRT_Ca</ci>
</apply>
</apply>
</apply>
<ci>Ca_i</ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci>J_R</ci>
<ci>g_D</ci>
</apply>
<apply>
<minus/>
<apply>
<times/>
<ci>Ca_o</ci>
<apply>
<exp/>
<apply>
<minus/>
<ci>FVRT_Ca</ci>
</apply>
</apply>
</apply>
<ci>Ca_SR</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>J_R</ci>
<ci>g_D</ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<apply>
<divide/>
<ci>J_L</ci>
<ci>g_D</ci>
</apply>
<ci>FVRT_Ca</ci>
</apply>
<apply>
<minus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<ci>FVRT_Ca</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<gt/>
<apply>
<abs/>
<ci>FVRT_Ca</ci>
</apply>
<cn cellml:units="dimensionless">0.00001</cn>
</apply>
</piece>
<otherwise>
<apply>
<divide/>
<apply>
<times/>
<apply>
<divide/>
<apply>
<times/>
<ci>J_L</ci>
<cn cellml:units="dimensionless">0.00001</cn>
</apply>
<apply>
<minus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<minus/>
<cn cellml:units="dimensionless">0.00001</cn>
</apply>
</apply>
</apply>
</apply>
<apply>
<plus/>
<apply>
<minus/>
<apply>
<times/>
<ci>Ca_o</ci>
<apply>
<exp/>
<apply>
<minus/>
<cn cellml:units="dimensionless">0.00001</cn>
</apply>
</apply>
</apply>
<ci>Ca_i</ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci>J_R</ci>
<ci>g_D</ci>
</apply>
<apply>
<minus/>
<apply>
<times/>
<ci>Ca_o</ci>
<apply>
<exp/>
<apply>
<minus/>
<cn cellml:units="dimensionless">0.00001</cn>
</apply>
</apply>
</apply>
<ci>Ca_SR</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>J_R</ci>
<ci>g_D</ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<apply>
<divide/>
<ci>J_L</ci>
<ci>g_D</ci>
</apply>
<cn cellml:units="dimensionless">0.00001</cn>
</apply>
<apply>
<minus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<minus/>
<cn cellml:units="dimensionless">0.00001</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
</otherwise>
</piecewise>
</apply>
</math>
</component>
<component name="CaRU_states">
<variable name="alpha_p" units="per_ms" public_interface="in"/>
<variable name="alpha_m" units="per_ms" public_interface="in"/>
<variable name="beta_pcc" units="per_ms" public_interface="in"/>
<variable name="beta_poc" units="per_ms" public_interface="in"/>
<variable name="beta_m" units="per_ms" public_interface="in"/>
<variable name="denom" units="per_ms3"/>
<variable name="P1" units="dimensionless" public_interface="out"/>
<variable name="P2" units="dimensionless" public_interface="out"/>
<variable name="P3" units="dimensionless" public_interface="out"/>
<variable name="P4" units="dimensionless" public_interface="out"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>denom</ci>
<apply>
<times/>
<apply>
<plus/>
<ci>alpha_p</ci>
<ci>alpha_m</ci>
</apply>
<apply>
<plus/>
<apply>
<times/>
<apply>
<plus/>
<ci>alpha_m</ci>
<ci>beta_m</ci>
<ci>beta_poc</ci>
</apply>
<apply>
<plus/>
<ci>beta_m</ci>
<ci>beta_pcc</ci>
</apply>
</apply>
<apply>
<times/>
<ci>alpha_p</ci>
<apply>
<plus/>
<ci>beta_m</ci>
<ci>beta_poc</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>P1</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>alpha_p</ci>
<ci>beta_m</ci>
<apply>
<plus/>
<ci>alpha_p</ci>
<ci>alpha_m</ci>
<ci>beta_m</ci>
<ci>beta_pcc</ci>
</apply>
</apply>
<ci>denom</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>P2</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>alpha_m</ci>
<apply>
<plus/>
<apply>
<times/>
<ci>beta_pcc</ci>
<apply>
<plus/>
<ci>alpha_m</ci>
<ci>beta_m</ci>
<ci>beta_poc</ci>
</apply>
</apply>
<apply>
<times/>
<ci>beta_poc</ci>
<ci>alpha_p</ci>
</apply>
</apply>
</apply>
<ci>denom</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>P3</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>alpha_p</ci>
<apply>
<plus/>
<apply>
<times/>
<ci>beta_poc</ci>
<apply>
<plus/>
<ci>alpha_p</ci>
<ci>beta_m</ci>
<ci>beta_pcc</ci>
</apply>
</apply>
<apply>
<times/>
<ci>beta_pcc</ci>
<ci>alpha_m</ci>
</apply>
</apply>
</apply>
<ci>denom</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>P4</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>alpha_m</ci>
<ci>beta_m</ci>
<apply>
<plus/>
<ci>alpha_m</ci>
<ci>alpha_p</ci>
<ci>beta_m</ci>
<ci>beta_poc</ci>
</apply>
</apply>
<ci>denom</ci>
</apply>
</apply>
</math>
</component>
<component name="CaRU_reduced_states">
<variable name="P1" units="dimensionless" public_interface="in"/>
<variable name="P4" units="dimensionless" public_interface="in"/>
<variable name="P2" units="dimensionless" public_interface="in"/>
<variable name="alpha_p" units="per_ms" public_interface="in"/>
<variable name="alpha_m" units="per_ms" public_interface="in"/>
<variable name="beta_pcc" units="per_ms" public_interface="in"/>
<variable name="beta_m" units="per_ms" public_interface="in"/>
<variable name="epsilon_pco" units="per_ms" public_interface="in"/>
<variable name="epsilon_pcc" units="per_ms" public_interface="in"/>
<variable name="epsilon_m" units="per_ms" public_interface="in"/>
<variable name="mu_poc" units="per_ms" public_interface="in"/>
<variable name="mu_pcc" units="per_ms" public_interface="in"/>
<variable name="mu_moc" units="per_ms" public_interface="in"/>
<variable name="mu_mcc" units="per_ms" public_interface="in"/>
<variable name="r_1" units="per_ms" public_interface="out"/>
<variable name="r_2" units="per_ms" public_interface="out"/>
<variable name="r_3" units="per_ms" public_interface="out"/>
<variable name="r_4" units="per_ms" public_interface="out"/>
<variable name="r_5" units="per_ms" public_interface="out"/>
<variable name="r_6" units="per_ms" public_interface="out"/>
<variable name="r_7" units="per_ms" public_interface="out"/>
<variable name="r_8" units="per_ms" public_interface="out"/>
<variable name="z_1" units="dimensionless" initial_value="0.990016532916529" public_interface="out"/>
<variable name="z_2" units="dimensionless" initial_value="0.00845823628523856" public_interface="out"/>
<variable name="z_3" units="dimensionless" initial_value="0.00151233172289407" public_interface="out"/>
<variable name="z_4" units="dimensionless" public_interface="out"/>
<variable name="time" units="ms" public_interface="in"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>r_1</ci>
<apply>
<plus/>
<apply>
<times/>
<ci>P1</ci>
<ci>mu_poc</ci>
</apply>
<apply>
<times/>
<ci>P4</ci>
<ci>mu_pcc</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>r_2</ci>
<apply>
<divide/>
<apply>
<plus/>
<apply>
<times/>
<ci>alpha_p</ci>
<ci>mu_moc</ci>
</apply>
<apply>
<times/>
<ci>alpha_m</ci>
<ci>mu_mcc</ci>
</apply>
</apply>
<apply>
<plus/>
<ci>alpha_p</ci>
<ci>alpha_m</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>r_3</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>beta_m</ci>
<ci>mu_pcc</ci>
</apply>
<apply>
<plus/>
<ci>beta_m</ci>
<ci>beta_pcc</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>r_4</ci>
<ci>mu_mcc</ci>
</apply>
<apply>
<eq/>
<ci>r_5</ci>
<apply>
<plus/>
<apply>
<times/>
<ci>P2</ci>
<ci>epsilon_pco</ci>
</apply>
<apply>
<times/>
<ci>P4</ci>
<ci>epsilon_pcc</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>r_6</ci>
<ci>epsilon_m</ci>
</apply>
<apply>
<eq/>
<ci>r_7</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>alpha_m</ci>
<ci>epsilon_pcc</ci>
</apply>
<apply>
<plus/>
<ci>alpha_p</ci>
<ci>alpha_m</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>r_8</ci>
<ci>epsilon_m</ci>
</apply>
<apply>
<eq/>
<ci>z_4</ci>
<apply>
<minus/>
<apply>
<minus/>
<apply>
<minus/>
<cn cellml:units="dimensionless">1</cn>
<ci>z_1</ci>
</apply>
<ci>z_2</ci>
</apply>
<ci>z_3</ci>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>z_1</ci>
</apply>
<apply>
<plus/>
<apply>
<times/>
<apply>
<minus/>
<apply>
<plus/>
<ci>r_1</ci>
<ci>r_5</ci>
</apply>
</apply>
<ci>z_1</ci>
</apply>
<apply>
<times/>
<ci>r_2</ci>
<ci>z_2</ci>
</apply>
<apply>
<times/>
<ci>r_6</ci>
<ci>z_3</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>z_2</ci>
</apply>
<apply>
<plus/>
<apply>
<minus/>
<apply>
<times/>
<ci>r_1</ci>
<ci>z_1</ci>
</apply>
<apply>
<times/>
<apply>
<plus/>
<ci>r_2</ci>
<ci>r_7</ci>
</apply>
<ci>z_2</ci>
</apply>
</apply>
<apply>
<times/>
<ci>r_8</ci>
<ci>z_4</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>z_3</ci>
</apply>
<apply>
<plus/>
<apply>
<minus/>
<apply>
<times/>
<ci>r_5</ci>
<ci>z_1</ci>
</apply>
<apply>
<times/>
<apply>
<plus/>
<ci>r_6</ci>
<ci>r_3</ci>
</apply>
<ci>z_3</ci>
</apply>
</apply>
<apply>
<times/>
<ci>r_4</ci>
<ci>z_4</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="RyR_current">
<variable name="P3" units="dimensionless" public_interface="in"/>
<variable name="P2" units="dimensionless" public_interface="in"/>
<variable name="P1" units="dimensionless" public_interface="in"/>
<variable name="beta_pcc" units="per_ms" public_interface="in"/>
<variable name="beta_m" units="per_ms" public_interface="in"/>
<variable name="J_Roo" units="um3_mM_per_ms" public_interface="in"/>
<variable name="J_Rco" units="um3_mM_per_ms" public_interface="in"/>
<variable name="z_1" units="dimensionless" public_interface="in"/>
<variable name="z_3" units="dimensionless" public_interface="in"/>
<variable name="Vmyo" units="um3" public_interface="in"/>
<variable name="N" units="dimensionless" public_interface="in"/>
<variable name="J_R1" units="um3_mM_per_ms" public_interface="out"/>
<variable name="J_R3" units="um3_mM_per_ms" public_interface="out"/>
<variable name="i_RyR1" units="mM_per_ms" public_interface="out"/>
<variable name="i_RyR2" units="mM_per_ms" public_interface="out"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>J_R1</ci>
<apply>
<plus/>
<apply>
<times/>
<ci>P3</ci>
<ci>J_Roo</ci>
</apply>
<apply>
<times/>
<ci>J_Rco</ci>
<ci>P2</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>J_R3</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>J_Rco</ci>
<ci>beta_pcc</ci>
</apply>
<apply>
<plus/>
<ci>beta_m</ci>
<ci>beta_pcc</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>i_RyR1</ci>
<apply>
<divide/>
<apply>
<times/>
<apply>
<plus/>
<apply>
<times/>
<ci>z_1</ci>
<ci>J_R1</ci>
</apply>
<apply>
<times/>
<ci>z_3</ci>
<ci>J_R3</ci>
</apply>
</apply>
<ci>N</ci>
</apply>
<ci>Vmyo</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>i_RyR2</ci>
<ci>i_RyR1</ci>
</apply>
</math>
</component>
<component name="LCC_current">
<variable name="F" units="coulomb_per_mole" public_interface="in"/>
<variable name="P3" units="dimensionless" public_interface="in"/>
<variable name="P1" units="dimensionless" public_interface="in"/>
<variable name="alpha_p" units="per_ms" public_interface="in"/>
<variable name="alpha_m" units="per_ms" public_interface="in"/>
<variable name="J_Loo" units="um3_mM_per_ms" public_interface="in"/>
<variable name="J_Loc" units="um3_mM_per_ms" public_interface="in"/>
<variable name="z_1" units="dimensionless" public_interface="in"/>
<variable name="z_2" units="dimensionless" public_interface="in"/>
<variable name="Vmyo" units="um3" public_interface="in"/>
<variable name="Vmyo_uL" units="uL" public_interface="in"/>
<variable name="N" units="dimensionless" public_interface="in"/>
<variable name="J_L1" units="um3_mM_per_ms" public_interface="out"/>
<variable name="J_L2" units="um3_mM_per_ms" public_interface="out"/>
<variable name="i_LCC1" units="mM_per_ms" public_interface="out"/>
<variable name="i_LCC2" units="uA" public_interface="out"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>J_L1</ci>
<apply>
<plus/>
<apply>
<times/>
<ci>J_Loo</ci>
<ci>P3</ci>
</apply>
<apply>
<times/>
<ci>J_Loc</ci>
<ci>P1</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>J_L2</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>J_Loc</ci>
<ci>alpha_p</ci>
</apply>
<apply>
<plus/>
<ci>alpha_p</ci>
<ci>alpha_m</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>i_LCC1</ci>
<apply>
<divide/>
<apply>
<times/>
<apply>
<plus/>
<apply>
<times/>
<ci>z_1</ci>
<ci>J_L1</ci>
</apply>
<apply>
<times/>
<ci>z_2</ci>
<ci>J_L2</ci>
</apply>
</apply>
<ci>N</ci>
</apply>
<ci>Vmyo</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>i_LCC2</ci>
<apply>
<times/>
<apply>
<minus/>
<ci>i_LCC1</ci>
</apply>
<cn cellml:units="dimensionless">2</cn>
<ci>F</ci>
<ci>Vmyo_uL</ci>
</apply>
</apply>
</math>
</component>
<component name="Na_Ca_Exchanger">
<variable name="FVRT" units="dimensionless" public_interface="in"/>
<variable name="F" units="coulomb_per_mole" public_interface="in"/>
<variable name="Vmyo_uL" units="uL" public_interface="in" private_interface="out"/>
<variable name="K_mNa" units="mM" initial_value="87.5"/>
<variable name="K_mCa" units="mM" initial_value="1.38"/>
<variable name="eta" units="dimensionless" initial_value="0.35"/>
<variable name="k_sat" units="dimensionless" initial_value="0.1"/>
<variable name="g_NCX" units="mM_per_ms" initial_value="0.0234"/>
<variable name="Na_i" units="mM" public_interface="in"/>
<variable name="Na_o" units="mM" public_interface="in"/>
<variable name="Ca_i" units="mM" public_interface="in"/>
<variable name="Ca_o" units="mM" public_interface="in"/>
<variable name="i_Ncx1" units="mM_per_ms" public_interface="out"/>
<variable name="i_Ncx2" units="uA" public_interface="out"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>i_Ncx1</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>g_NCX</ci>
<apply>
<minus/>
<apply>
<times/>
<apply>
<exp/>
<apply>
<times/>
<ci>eta</ci>
<ci>FVRT</ci>
</apply>
</apply>
<apply>
<power/>
<ci>Na_i</ci>
<cn cellml:units="dimensionless">3</cn>
</apply>
<ci>Ca_o</ci>
</apply>
<apply>
<times/>
<apply>
<exp/>
<apply>
<times/>
<apply>
<minus/>
<ci>eta</ci>
<cn cellml:units="dimensionless">1</cn>
</apply>
<ci>FVRT</ci>
</apply>
</apply>
<apply>
<power/>
<ci>Na_o</ci>
<cn cellml:units="dimensionless">3</cn>
</apply>
<ci>Ca_i</ci>
</apply>
</apply>
</apply>
<apply>
<times/>
<apply>
<plus/>
<apply>
<power/>
<ci>Na_o</ci>
<cn cellml:units="dimensionless">3</cn>
</apply>
<apply>
<power/>
<ci>K_mNa</ci>
<cn cellml:units="dimensionless">3</cn>
</apply>
</apply>
<apply>
<plus/>
<ci>Ca_o</ci>
<ci>K_mCa</ci>
</apply>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<times/>
<ci>k_sat</ci>
<apply>
<exp/>
<apply>
<times/>
<apply>
<minus/>
<ci>eta</ci>
<cn cellml:units="dimensionless">1</cn>
</apply>
<ci>FVRT</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>i_Ncx2</ci>
<apply>
<times/>
<ci>i_Ncx1</ci>
<ci>F</ci>
<ci>Vmyo_uL</ci>
</apply>
</apply>
</math>
</component>
<component name="SERCA">
<variable name="g_SERCA" units="mM_per_ms" initial_value="0.000235"/>
<variable name="K_SERCA" units="mM" initial_value="0.0004968"/>
<variable name="i_SERCA" units="mM_per_ms" public_interface="out"/>
<variable name="Ca_i" units="mM" public_interface="in"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>i_SERCA</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>g_SERCA</ci>
<apply>
<power/>
<ci>Ca_i</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
<apply>
<plus/>
<apply>
<power/>
<ci>K_SERCA</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
<apply>
<power/>
<ci>Ca_i</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="SarcolemMal_Ca_pump">
<variable name="F" units="coulomb_per_mole" public_interface="in"/>
<variable name="Vmyo_uL" units="uL" public_interface="in" private_interface="out"/>
<variable name="g_pCa" units="mM_per_ms" initial_value="5e-6"/>
<variable name="K_mpCa" units="mM" initial_value="0.00035"/>
<variable name="Ca_i" units="mM" public_interface="in"/>
<variable name="i_pCa1" units="mM_per_ms" public_interface="out"/>
<variable name="i_pCa2" units="uA" public_interface="out"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>i_pCa1</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>g_pCa</ci>
<ci>Ca_i</ci>
</apply>
<apply>
<plus/>
<ci>K_mpCa</ci>
<ci>Ca_i</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>i_pCa2</ci>
<apply>
<times/>
<ci>i_pCa1</ci>
<cn cellml:units="dimensionless">2</cn>
<ci>F</ci>
<ci>Vmyo_uL</ci>
</apply>
</apply>
</math>
</component>
<component name="Background_Ca_current">
<variable name="V" units="mV" public_interface="in"/>
<variable name="R" units="mJ_per_mole_K" public_interface="in"/>
<variable name="T" units="kelvin" public_interface="in"/>
<variable name="F" units="C_per_mole" public_interface="in"/>
<variable name="Vmyo_uL" units="uL" public_interface="in" private_interface="out"/>
<variable name="Ca_i" units="mM" public_interface="in"/>
<variable name="Ca_o" units="mM" public_interface="in"/>
<variable name="E_Ca" units="mV" public_interface="out"/>
<variable name="g_CaB" units="mM_per_mV_ms" initial_value="2e-8"/>
<variable name="i_CaB1" units="mM_per_ms" public_interface="out"/>
<variable name="i_CaB2" units="uA" public_interface="out"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>E_Ca</ci>
<apply>
<times/>
<apply>
<divide/>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
<apply>
<times/>
<cn cellml:units="dimensionless">2</cn>
<ci>F</ci>
</apply>
</apply>
<apply>
<ln/>
<apply>
<divide/>
<ci>Ca_o</ci>
<ci>Ca_i</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>i_CaB1</ci>
<apply>
<times/>
<ci>g_CaB</ci>
<apply>
<minus/>
<ci>E_Ca</ci>
<ci>V</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>i_CaB2</ci>
<apply>
<times/>
<apply>
<minus/>
<ci>i_CaB1</ci>
</apply>
<cn cellml:units="dimensionless">2</cn>
<ci>F</ci>
<ci>Vmyo_uL</ci>
</apply>
</apply>
</math>
</component>
<component name="SR_Ca_leak_current">
<variable name="Ca_i" units="mM" public_interface="in"/>
<variable name="Ca_SR" units="mM" public_interface="in"/>
<variable name="g_SRl" units="per_ms" initial_value="1e-6"/>
<variable name="i_SR" units="mM_per_ms" public_interface="out"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>i_SR</ci>
<apply>
<times/>
<ci>g_SRl</ci>
<apply>
<minus/>
<ci>Ca_SR</ci>
<ci>Ca_i</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="troponin_Ca_buffer">
<variable name="k_m_TRPN" units="per_ms" initial_value="0.04"/>
<variable name="k_p_TRPN" units="per_mM_ms" initial_value="40"/>
<variable name="B_TRPN" units="mM" initial_value="0.07"/>
<variable name="TRPN" units="mM" public_interface="in"/>
<variable name="Ca_i" units="mM" public_interface="in"/>
<variable name="i_TRPN" units="mM_per_ms" public_interface="out"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>i_TRPN</ci>
<apply>
<minus/>
<apply>
<times/>
<ci>k_m_TRPN</ci>
<apply>
<minus/>
<ci>B_TRPN</ci>
<ci>TRPN</ci>
</apply>
</apply>
<apply>
<times/>
<ci>k_p_TRPN</ci>
<ci>TRPN</ci>
<ci>Ca_i</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="calmodulin_Ca_buffer">
<variable name="k_CMDN" units="mM" initial_value="0.002382"/>
<variable name="B_CMDN" units="mM" initial_value="0.05"/>
<variable name="Ca_i" units="mM" public_interface="in"/>
<variable name="beta_CMDN" units="dimensionless" public_interface="out"/>
<variable name="EGTA_tot" units="mM" initial_value="0"/>
<variable name="KmEGTA" units="mM" initial_value="0.00015"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>beta_CMDN</ci>
<apply>
<power/>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<apply>
<times/>
<ci>k_CMDN</ci>
<ci>B_CMDN</ci>
</apply>
<apply>
<power/>
<apply>
<plus/>
<ci>k_CMDN</ci>
<ci>Ca_i</ci>
</apply>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>EGTA_tot</ci>
<ci>KmEGTA</ci>
</apply>
<apply>
<power/>
<apply>
<plus/>
<ci>KmEGTA</ci>
<ci>Ca_i</ci>
</apply>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
<apply>
<minus/>
<cn cellml:units="dimensionless">1</cn>
</apply>
</apply>
</apply>
</math>
</component>
<component name="intracellular_ion_concentrations">
<variable name="Na_i" units="mM" initial_value="8.46899983583716" public_interface="out"/>
<variable name="Ca_i" units="mM" initial_value="0.000103020385969363" public_interface="out"/>
<variable name="K_i" units="mM" initial_value="142.919492013701" public_interface="out"/>
<variable name="Ca_SR" units="mM" initial_value="0.96268028201207" public_interface="out"/>
<variable name="TRPN" units="mM" initial_value="0.0633670056927004" public_interface="out"/>
<variable name="Vmyo_uL" units="uL" public_interface="in"/>
<variable name="VSR_uL" units="uL" public_interface="in"/>
<variable name="time" units="ms" public_interface="in"/>
<variable name="F" units="C_per_mole" public_interface="in"/>
<variable name="beta_CMDN" units="dimensionless" public_interface="in"/>
<variable name="i_Na" units="uA" public_interface="in"/>
<variable name="i_B_Na" units="uA" public_interface="in"/>
<variable name="i_B_K" units="uA" public_interface="in"/>
<variable name="i_f_Na" units="uA" public_interface="in"/>
<variable name="i_f_K" units="uA" public_interface="in"/>
<variable name="i_ss" units="uA" public_interface="in"/>
<variable name="i_SERCA" units="mM_per_ms" public_interface="in"/>
<variable name="i_pCa2" units="uA" public_interface="in"/>
<variable name="i_CaB2" units="uA" public_interface="in"/>
<variable name="i_TRPN" units="mM_per_ms" public_interface="in"/>
<variable name="i_SR" units="mM_per_ms" public_interface="in"/>
<variable name="i_Ncx2" units="uA" public_interface="in"/>
<variable name="i_RyR2" units="mM_per_ms" public_interface="in"/>
<variable name="i_LCC2" units="uA" public_interface="in"/>
<variable name="i_Stim" units="uA" public_interface="in"/>
<variable name="i_t" units="uA" public_interface="in"/>
<variable name="i_K1" units="uA" public_interface="in"/>
<variable name="i_NaK" units="uA" public_interface="in"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>Na_i</ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<apply>
<minus/>
<apply>
<plus/>
<ci>i_Na</ci>
<ci>i_B_Na</ci>
<apply>
<times/>
<ci>i_Ncx2</ci>
<cn cellml:units="dimensionless">3</cn>
</apply>
<apply>
<times/>
<ci>i_NaK</ci>
<cn cellml:units="dimensionless">3</cn>
</apply>
<ci>i_f_Na</ci>
</apply>
</apply>
<cn cellml:units="dimensionless">1</cn>
</apply>
<apply>
<times/>
<ci>Vmyo_uL</ci>
<ci>F</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>K_i</ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<apply>
<minus/>
<apply>
<plus/>
<ci>i_Stim</ci>
<ci>i_ss</ci>
<ci>i_B_K</ci>
<ci>i_t</ci>
<ci>i_K1</ci>
<ci>i_f_K</ci>
<apply>
<times/>
<apply>
<minus/>
<cn cellml:units="dimensionless">2</cn>
</apply>
<ci>i_NaK</ci>
</apply>
</apply>
</apply>
<cn cellml:units="dimensionless">1</cn>
</apply>
<apply>
<times/>
<ci>Vmyo_uL</ci>
<ci>F</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>TRPN</ci>
</apply>
<ci>i_TRPN</ci>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>Ca_i</ci>
</apply>
<apply>
<times/>
<ci>beta_CMDN</ci>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<minus/>
<ci>i_RyR2</ci>
<ci>i_SERCA</ci>
</apply>
<ci>i_SR</ci>
<ci>i_TRPN</ci>
</apply>
<apply>
<divide/>
<apply>
<plus/>
<apply>
<times/>
<apply>
<minus/>
<cn cellml:units="dimensionless">2</cn>
</apply>
<ci>i_Ncx2</ci>
</apply>
<ci>i_LCC2</ci>
<ci>i_pCa2</ci>
<ci>i_CaB2</ci>
</apply>
<apply>
<times/>
<cn cellml:units="dimensionless">2</cn>
<ci>Vmyo_uL</ci>
<ci>F</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>Ca_SR</ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<ci>Vmyo_uL</ci>
<ci>VSR_uL</ci>
</apply>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<minus/>
<ci>i_RyR2</ci>
</apply>
<ci>i_SERCA</ci>
</apply>
<ci>i_SR</ci>
</apply>
</apply>
</apply>
</math>
</component>
<group>
<relationship_ref relationship="containment"/>
<component_ref component="membrane">
<component_ref component="sodium_current">
<component_ref component="sodium_current_m_gate"/>
<component_ref component="sodium_current_h_gate"/>
<component_ref component="sodium_current_j_gate"/>
</component_ref>
<component_ref component="Ca_independent_transient_outward_K_current">
<component_ref component="Ca_independent_transient_outward_K_current_r_gate"/>
<component_ref component="Ca_independent_transient_outward_K_current_s_gate"/>
<component_ref component="Ca_independent_transient_outward_K_current_s_slow_gate"/>
</component_ref>
<component_ref component="steady_state_outward_K_current">
<component_ref component="steady_state_outward_K_current_r_ss_gate"/>
<component_ref component="steady_state_outward_K_current_s_ss_gate"/>
</component_ref>
<component_ref component="inward_rectifier"/>
<component_ref component="hyperpolarisation_activated_current">
<component_ref component="hyperpolarisation_activated_current_y_gate"/>
</component_ref>
<component_ref component="background_currents"/>
<component_ref component="sodium_potassium_pump"/>
<component_ref component="intracellular_ion_concentrations"/>
<component_ref component="extracellular_ion_concentrations"/>
<component_ref component="cell_geometry"/>
<component_ref component="CaRU">
<component_ref component="CaRU_Transitions"/>
<component_ref component="CaRU_states"/>
<component_ref component="CaRU_reduced_states"/>
<component_ref component="DS_Calcium_Concentrations"/>
<component_ref component="LCC_and_RyR_fluxes"/>
<component_ref component="RyR_current"/>
<component_ref component="LCC_current"/>
</component_ref>
<component_ref component="Na_Ca_Exchanger"/>
<component_ref component="SERCA"/>
<component_ref component="SarcolemMal_Ca_pump"/>
<component_ref component="Background_Ca_current"/>
<component_ref component="SR_Ca_leak_current"/>
<component_ref component="troponin_Ca_buffer"/>
<component_ref component="calmodulin_Ca_buffer"/>
</component_ref>
</group>
<group>
<relationship_ref relationship="encapsulation"/>
<component_ref component="sodium_current">
<component_ref component="sodium_current_m_gate"/>
<component_ref component="sodium_current_h_gate"/>
<component_ref component="sodium_current_j_gate"/>
</component_ref>
<component_ref component="Ca_independent_transient_outward_K_current">
<component_ref component="Ca_independent_transient_outward_K_current_r_gate"/>
<component_ref component="Ca_independent_transient_outward_K_current_s_gate"/>
<component_ref component="Ca_independent_transient_outward_K_current_s_slow_gate"/>
</component_ref>
<component_ref component="steady_state_outward_K_current">
<component_ref component="steady_state_outward_K_current_r_ss_gate"/>
<component_ref component="steady_state_outward_K_current_s_ss_gate"/>
</component_ref>
<component_ref component="hyperpolarisation_activated_current">
<component_ref component="hyperpolarisation_activated_current_y_gate"/>
</component_ref>
<component_ref component="CaRU">
<component_ref component="CaRU_Transitions"/>
<component_ref component="CaRU_states"/>
<component_ref component="CaRU_reduced_states"/>
<component_ref component="DS_Calcium_Concentrations"/>
<component_ref component="LCC_and_RyR_fluxes"/>
<component_ref component="RyR_current"/>
<component_ref component="LCC_current"/>
</component_ref>
</group>
<connection>
<map_components component_1="membrane" component_2="environment"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="sodium_current" component_2="environment"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="Ca_independent_transient_outward_K_current" component_2="environment"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="steady_state_outward_K_current" component_2="environment"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="hyperpolarisation_activated_current" component_2="environment"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="CaRU" component_2="environment"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="environment" component_2="intracellular_ion_concentrations"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="membrane" component_2="intracellular_ion_concentrations"/>
<map_variables variable_1="i_Stim" variable_2="i_Stim"/>
<map_variables variable_1="F" variable_2="F"/>
</connection>
<connection>
<map_components component_1="sodium_current" component_2="membrane"/>
<map_variables variable_1="i_Na" variable_2="i_Na"/>
<map_variables variable_1="F" variable_2="F"/>
<map_variables variable_1="V" variable_2="V"/>
<map_variables variable_1="R" variable_2="R"/>
<map_variables variable_1="T" variable_2="T"/>
</connection>
<connection>
<map_components component_1="Ca_independent_transient_outward_K_current" component_2="membrane"/>
<map_variables variable_1="i_t" variable_2="i_t"/>
<map_variables variable_1="F" variable_2="F"/>
<map_variables variable_1="V" variable_2="V"/>
<map_variables variable_1="R" variable_2="R"/>
<map_variables variable_1="T" variable_2="T"/>
</connection>
<connection>
<map_components component_1="steady_state_outward_K_current" component_2="membrane"/>
<map_variables variable_1="i_ss" variable_2="i_ss"/>
<map_variables variable_1="V" variable_2="V"/>
</connection>
<connection>
<map_components component_1="inward_rectifier" component_2="membrane"/>
<map_variables variable_1="i_K1" variable_2="i_K1"/>
<map_variables variable_1="F" variable_2="F"/>
<map_variables variable_1="V" variable_2="V"/>
<map_variables variable_1="R" variable_2="R"/>
<map_variables variable_1="T" variable_2="T"/>
</connection>
<connection>
<map_components component_1="hyperpolarisation_activated_current" component_2="membrane"/>
<map_variables variable_1="i_f" variable_2="i_f"/>
<map_variables variable_1="V" variable_2="V"/>
</connection>
<connection>
<map_components component_1="background_currents" component_2="membrane"/>
<map_variables variable_1="i_B_Na" variable_2="i_B_Na"/>
<map_variables variable_1="i_B_K" variable_2="i_B_K"/>
<map_variables variable_1="V" variable_2="V"/>
</connection>
<connection>
<map_components component_1="sodium_potassium_pump" component_2="membrane"/>
<map_variables variable_1="i_NaK" variable_2="i_NaK"/>
<map_variables variable_1="F" variable_2="F"/>
<map_variables variable_1="V" variable_2="V"/>
<map_variables variable_1="R" variable_2="R"/>
<map_variables variable_1="T" variable_2="T"/>
</connection>
<connection>
<map_components component_1="CaRU" component_2="membrane"/>
<map_variables variable_1="F" variable_2="F"/>
<map_variables variable_1="V" variable_2="V"/>
<map_variables variable_1="FVRT_Ca" variable_2="FVRT_Ca"/>
<map_variables variable_1="i_LCC2" variable_2="i_LCC2"/>
</connection>
<connection>
<map_components component_1="Na_Ca_Exchanger" component_2="membrane"/>
<map_variables variable_1="F" variable_2="F"/>
<map_variables variable_1="FVRT" variable_2="FVRT"/>
<map_variables variable_1="i_Ncx2" variable_2="i_Ncx2"/>
</connection>
<connection>
<map_components component_1="SarcolemMal_Ca_pump" component_2="membrane"/>
<map_variables variable_1="F" variable_2="F"/>
<map_variables variable_1="i_pCa2" variable_2="i_pCa2"/>
</connection>
<connection>
<map_components component_1="Background_Ca_current" component_2="membrane"/>
<map_variables variable_1="F" variable_2="F"/>
<map_variables variable_1="T" variable_2="T"/>
<map_variables variable_1="R" variable_2="R"/>
<map_variables variable_1="V" variable_2="V"/>
<map_variables variable_1="i_CaB2" variable_2="i_CaB2"/>
</connection>
<connection>
<map_components component_1="sodium_current" component_2="intracellular_ion_concentrations"/>
<map_variables variable_1="i_Na" variable_2="i_Na"/>
<map_variables variable_1="Na_i" variable_2="Na_i"/>
</connection>
<connection>
<map_components component_1="Ca_independent_transient_outward_K_current" component_2="intracellular_ion_concentrations"/>
<map_variables variable_1="i_t" variable_2="i_t"/>
<map_variables variable_1="K_i" variable_2="K_i"/>
</connection>
<connection>
<map_components component_1="steady_state_outward_K_current" component_2="intracellular_ion_concentrations"/>
<map_variables variable_1="i_ss" variable_2="i_ss"/>
</connection>
<connection>
<map_components component_1="inward_rectifier" component_2="intracellular_ion_concentrations"/>
<map_variables variable_1="i_K1" variable_2="i_K1"/>
<map_variables variable_1="K_i" variable_2="K_i"/>
</connection>
<connection>
<map_components component_1="hyperpolarisation_activated_current" component_2="intracellular_ion_concentrations"/>
<map_variables variable_1="i_f_Na" variable_2="i_f_Na"/>
<map_variables variable_1="i_f_K" variable_2="i_f_K"/>
</connection>
<connection>
<map_components component_1="background_currents" component_2="intracellular_ion_concentrations"/>
<map_variables variable_1="i_B_Na" variable_2="i_B_Na"/>
<map_variables variable_1="i_B_K" variable_2="i_B_K"/>
</connection>
<connection>
<map_components component_1="sodium_potassium_pump" component_2="intracellular_ion_concentrations"/>
<map_variables variable_1="i_NaK" variable_2="i_NaK"/>
<map_variables variable_1="Na_i" variable_2="Na_i"/>
</connection>
<connection>
<map_components component_1="sodium_current" component_2="extracellular_ion_concentrations"/>
<map_variables variable_1="Na_o" variable_2="Na_o"/>
</connection>
<connection>
<map_components component_1="Ca_independent_transient_outward_K_current" component_2="extracellular_ion_concentrations"/>
<map_variables variable_1="K_o" variable_2="K_o"/>
</connection>
<connection>
<map_components component_1="inward_rectifier" component_2="extracellular_ion_concentrations"/>
<map_variables variable_1="K_o" variable_2="K_o"/>
</connection>
<connection>
<map_components component_1="sodium_potassium_pump" component_2="extracellular_ion_concentrations"/>
<map_variables variable_1="K_o" variable_2="K_o"/>
<map_variables variable_1="Na_o" variable_2="Na_o"/>
</connection>
<connection>
<map_components component_1="Ca_independent_transient_outward_K_current" component_2="steady_state_outward_K_current"/>
<map_variables variable_1="E_K" variable_2="E_K"/>
</connection>
<connection>
<map_components component_1="Ca_independent_transient_outward_K_current" component_2="inward_rectifier"/>
<map_variables variable_1="E_K" variable_2="E_K"/>
</connection>
<connection>
<map_components component_1="Ca_independent_transient_outward_K_current" component_2="hyperpolarisation_activated_current"/>
<map_variables variable_1="E_K" variable_2="E_K"/>
</connection>
<connection>
<map_components component_1="Ca_independent_transient_outward_K_current" component_2="background_currents"/>
<map_variables variable_1="E_K" variable_2="E_K"/>
</connection>
<connection>
<map_components component_1="sodium_current" component_2="background_currents"/>
<map_variables variable_1="E_Na" variable_2="E_Na"/>
</connection>
<connection>
<map_components component_1="sodium_current" component_2="hyperpolarisation_activated_current"/>
<map_variables variable_1="E_Na" variable_2="E_Na"/>
</connection>
<connection>
<map_components component_1="cell_geometry" component_2="intracellular_ion_concentrations"/>
<map_variables variable_1="Vmyo_uL" variable_2="Vmyo_uL"/>
<map_variables variable_1="VSR_uL" variable_2="VSR_uL"/>
</connection>
<connection>
<map_components component_1="cell_geometry" component_2="Na_Ca_Exchanger"/>
<map_variables variable_1="Vmyo_uL" variable_2="Vmyo_uL"/>
</connection>
<connection>
<map_components component_1="cell_geometry" component_2="SarcolemMal_Ca_pump"/>
<map_variables variable_1="Vmyo_uL" variable_2="Vmyo_uL"/>
</connection>
<connection>
<map_components component_1="cell_geometry" component_2="Background_Ca_current"/>
<map_variables variable_1="Vmyo_uL" variable_2="Vmyo_uL"/>
</connection>
<connection>
<map_components component_1="cell_geometry" component_2="CaRU"/>
<map_variables variable_1="Vmyo" variable_2="Vmyo"/>
<map_variables variable_1="Vmyo_uL" variable_2="Vmyo_uL"/>
</connection>
<connection>
<map_components component_1="intracellular_ion_concentrations" component_2="calmodulin_Ca_buffer"/>
<map_variables variable_1="Ca_i" variable_2="Ca_i"/>
<map_variables variable_1="beta_CMDN" variable_2="beta_CMDN"/>
</connection>
<connection>
<map_components component_1="intracellular_ion_concentrations" component_2="CaRU"/>
<map_variables variable_1="Ca_i" variable_2="Ca_i"/>
<map_variables variable_1="Ca_SR" variable_2="Ca_SR"/>
<map_variables variable_1="i_RyR2" variable_2="i_RyR2"/>
<map_variables variable_1="i_LCC2" variable_2="i_LCC2"/>
</connection>
<connection>
<map_components component_1="intracellular_ion_concentrations" component_2="Na_Ca_Exchanger"/>
<map_variables variable_1="Na_i" variable_2="Na_i"/>
<map_variables variable_1="Ca_i" variable_2="Ca_i"/>
<map_variables variable_1="i_Ncx2" variable_2="i_Ncx2"/>
</connection>
<connection>
<map_components component_1="intracellular_ion_concentrations" component_2="SERCA"/>
<map_variables variable_1="Ca_i" variable_2="Ca_i"/>
<map_variables variable_1="i_SERCA" variable_2="i_SERCA"/>
</connection>
<connection>
<map_components component_1="intracellular_ion_concentrations" component_2="SarcolemMal_Ca_pump"/>
<map_variables variable_1="Ca_i" variable_2="Ca_i"/>
<map_variables variable_1="i_pCa2" variable_2="i_pCa2"/>
</connection>
<connection>
<map_components component_1="intracellular_ion_concentrations" component_2="Background_Ca_current"/>
<map_variables variable_1="Ca_i" variable_2="Ca_i"/>
<map_variables variable_1="i_CaB2" variable_2="i_CaB2"/>
</connection>
<connection>
<map_components component_1="intracellular_ion_concentrations" component_2="SR_Ca_leak_current"/>
<map_variables variable_1="Ca_i" variable_2="Ca_i"/>
<map_variables variable_1="Ca_SR" variable_2="Ca_SR"/>
<map_variables variable_1="i_SR" variable_2="i_SR"/>
</connection>
<connection>
<map_components component_1="intracellular_ion_concentrations" component_2="troponin_Ca_buffer"/>
<map_variables variable_1="Ca_i" variable_2="Ca_i"/>
<map_variables variable_1="TRPN" variable_2="TRPN"/>
<map_variables variable_1="i_TRPN" variable_2="i_TRPN"/>
</connection>
<connection>
<map_components component_1="CaRU" component_2="extracellular_ion_concentrations"/>
<map_variables variable_1="Ca_o" variable_2="Ca_o"/>
</connection>
<connection>
<map_components component_1="Na_Ca_Exchanger" component_2="extracellular_ion_concentrations"/>
<map_variables variable_1="Ca_o" variable_2="Ca_o"/>
<map_variables variable_1="Na_o" variable_2="Na_o"/>
</connection>
<connection>
<map_components component_1="Background_Ca_current" component_2="extracellular_ion_concentrations"/>
<map_variables variable_1="Ca_o" variable_2="Ca_o"/>
</connection>
<connection>
<map_components component_1="sodium_current" component_2="sodium_current_m_gate"/>
<map_variables variable_1="m" variable_2="m"/>
<map_variables variable_1="time" variable_2="time"/>
<map_variables variable_1="V" variable_2="V"/>
</connection>
<connection>
<map_components component_1="sodium_current" component_2="sodium_current_h_gate"/>
<map_variables variable_1="h" variable_2="h"/>
<map_variables variable_1="time" variable_2="time"/>
<map_variables variable_1="V" variable_2="V"/>
</connection>
<connection>
<map_components component_1="sodium_current" component_2="sodium_current_j_gate"/>
<map_variables variable_1="j" variable_2="j"/>
<map_variables variable_1="time" variable_2="time"/>
<map_variables variable_1="V" variable_2="V"/>
</connection>
<connection>
<map_components component_1="Ca_independent_transient_outward_K_current" component_2="Ca_independent_transient_outward_K_current_r_gate"/>
<map_variables variable_1="r" variable_2="r"/>
<map_variables variable_1="time" variable_2="time"/>
<map_variables variable_1="V" variable_2="V"/>
</connection>
<connection>
<map_components component_1="Ca_independent_transient_outward_K_current" component_2="Ca_independent_transient_outward_K_current_s_gate"/>
<map_variables variable_1="s" variable_2="s"/>
<map_variables variable_1="time" variable_2="time"/>
<map_variables variable_1="V" variable_2="V"/>
</connection>
<connection>
<map_components component_1="Ca_independent_transient_outward_K_current" component_2="Ca_independent_transient_outward_K_current_s_slow_gate"/>
<map_variables variable_1="s_slow" variable_2="s_slow"/>
<map_variables variable_1="time" variable_2="time"/>
<map_variables variable_1="V" variable_2="V"/>
</connection>
<connection>
<map_components component_1="steady_state_outward_K_current" component_2="steady_state_outward_K_current_r_ss_gate"/>
<map_variables variable_1="r_ss" variable_2="r_ss"/>
<map_variables variable_1="time" variable_2="time"/>
<map_variables variable_1="V" variable_2="V"/>
</connection>
<connection>
<map_components component_1="steady_state_outward_K_current" component_2="steady_state_outward_K_current_s_ss_gate"/>
<map_variables variable_1="s_ss" variable_2="s_ss"/>
<map_variables variable_1="time" variable_2="time"/>
<map_variables variable_1="V" variable_2="V"/>
</connection>
<connection>
<map_components component_1="hyperpolarisation_activated_current" component_2="hyperpolarisation_activated_current_y_gate"/>
<map_variables variable_1="y" variable_2="y"/>
<map_variables variable_1="time" variable_2="time"/>
<map_variables variable_1="V" variable_2="V"/>
</connection>
<connection>
<map_components component_1="CaRU" component_2="CaRU_reduced_states"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="CaRU" component_2="LCC_and_RyR_fluxes"/>
<map_variables variable_1="g_D" variable_2="g_D"/>
<map_variables variable_1="J_R" variable_2="J_R"/>
<map_variables variable_1="J_L" variable_2="J_L"/>
<map_variables variable_1="Ca_i" variable_2="Ca_i"/>
<map_variables variable_1="Ca_SR" variable_2="Ca_SR"/>
<map_variables variable_1="Ca_o" variable_2="Ca_o"/>
<map_variables variable_1="FVRT_Ca" variable_2="FVRT_Ca"/>
</connection>
<connection>
<map_components component_1="CaRU" component_2="CaRU_Transitions"/>
<map_variables variable_1="V" variable_2="V"/>
<map_variables variable_1="Ca_i" variable_2="Ca_i"/>
</connection>
<connection>
<map_components component_1="CaRU_Transitions" component_2="CaRU_states"/>
<map_variables variable_1="alpha_p" variable_2="alpha_p"/>
<map_variables variable_1="alpha_m" variable_2="alpha_m"/>
<map_variables variable_1="beta_pcc" variable_2="beta_pcc"/>
<map_variables variable_1="beta_poc" variable_2="beta_poc"/>
<map_variables variable_1="beta_m" variable_2="beta_m"/>
</connection>
<connection>
<map_components component_1="CaRU_Transitions" component_2="RyR_current"/>
<map_variables variable_1="beta_pcc" variable_2="beta_pcc"/>
<map_variables variable_1="beta_m" variable_2="beta_m"/>
</connection>
<connection>
<map_components component_1="CaRU_Transitions" component_2="LCC_current"/>
<map_variables variable_1="alpha_p" variable_2="alpha_p"/>
<map_variables variable_1="alpha_m" variable_2="alpha_m"/>
</connection>
<connection>
<map_components component_1="CaRU_states" component_2="RyR_current"/>
<map_variables variable_1="P3" variable_2="P3"/>
<map_variables variable_1="P2" variable_2="P2"/>
<map_variables variable_1="P1" variable_2="P1"/>
</connection>
<connection>
<map_components component_1="CaRU_states" component_2="LCC_current"/>
<map_variables variable_1="P3" variable_2="P3"/>
<map_variables variable_1="P1" variable_2="P1"/>
</connection>
<connection>
<map_components component_1="LCC_and_RyR_fluxes" component_2="RyR_current"/>
<map_variables variable_1="J_Roo" variable_2="J_Roo"/>
<map_variables variable_1="J_Rco" variable_2="J_Rco"/>
</connection>
<connection>
<map_components component_1="LCC_and_RyR_fluxes" component_2="LCC_current"/>
<map_variables variable_1="J_Loo" variable_2="J_Loo"/>
<map_variables variable_1="J_Loc" variable_2="J_Loc"/>
</connection>
<connection>
<map_components component_1="CaRU_reduced_states" component_2="RyR_current"/>
<map_variables variable_1="z_1" variable_2="z_1"/>
<map_variables variable_1="z_3" variable_2="z_3"/>
</connection>
<connection>
<map_components component_1="CaRU_reduced_states" component_2="LCC_current"/>
<map_variables variable_1="z_1" variable_2="z_1"/>
<map_variables variable_1="z_2" variable_2="z_2"/>
</connection>
<connection>
<map_components component_1="DS_Calcium_Concentrations" component_2="CaRU_Transitions"/>
<map_variables variable_1="C_oc" variable_2="C_oc"/>
<map_variables variable_1="C_co" variable_2="C_co"/>
</connection>
<connection>
<map_components component_1="CaRU_Transitions" component_2="CaRU_reduced_states"/>
<map_variables variable_1="alpha_p" variable_2="alpha_p"/>
<map_variables variable_1="alpha_m" variable_2="alpha_m"/>
<map_variables variable_1="beta_pcc" variable_2="beta_pcc"/>
<map_variables variable_1="beta_m" variable_2="beta_m"/>
<map_variables variable_1="epsilon_pco" variable_2="epsilon_pco"/>
<map_variables variable_1="epsilon_pcc" variable_2="epsilon_pcc"/>
<map_variables variable_1="epsilon_m" variable_2="epsilon_m"/>
<map_variables variable_1="mu_poc" variable_2="mu_poc"/>
<map_variables variable_1="mu_pcc" variable_2="mu_pcc"/>
<map_variables variable_1="mu_moc" variable_2="mu_moc"/>
<map_variables variable_1="mu_mcc" variable_2="mu_mcc"/>
</connection>
<connection>
<map_components component_1="CaRU_states" component_2="CaRU_reduced_states"/>
<map_variables variable_1="P1" variable_2="P1"/>
<map_variables variable_1="P4" variable_2="P4"/>
<map_variables variable_1="P2" variable_2="P2"/>
</connection>
<connection>
<map_components component_1="CaRU" component_2="DS_Calcium_Concentrations"/>
<map_variables variable_1="g_D" variable_2="g_D"/>
<map_variables variable_1="J_R" variable_2="J_R"/>
<map_variables variable_1="J_L" variable_2="J_L"/>
<map_variables variable_1="Ca_i" variable_2="Ca_i"/>
<map_variables variable_1="Ca_o" variable_2="Ca_o"/>
<map_variables variable_1="Ca_SR" variable_2="Ca_SR"/>
<map_variables variable_1="FVRT_Ca" variable_2="FVRT_Ca"/>
</connection>
<connection>
<map_components component_1="CaRU" component_2="RyR_current"/>
<map_variables variable_1="N" variable_2="N"/>
<map_variables variable_1="Vmyo" variable_2="Vmyo"/>
<map_variables variable_1="i_RyR2" variable_2="i_RyR2"/>
</connection>
<connection>
<map_components component_1="CaRU" component_2="LCC_current"/>
<map_variables variable_1="i_LCC2" variable_2="i_LCC2"/>
<map_variables variable_1="Vmyo" variable_2="Vmyo"/>
<map_variables variable_1="Vmyo_uL" variable_2="Vmyo_uL"/>
<map_variables variable_1="N" variable_2="N"/>
<map_variables variable_1="F" variable_2="F"/>
</connection>
</model>
