Covering a Broad Dynamic Range: Information Processing at the Erythropoietin Receptor

Exposure Information

Latest Exposure To the presentational view for the most recent revision of data reviewed and published from this workspace.

Workspace Summary

Description

Cell surface receptors convert extracellular cues into receptor activation, thereby triggering intracellular signaling networks and controlling cellular decisions. A major unresolved issue is the identification of receptor properties that critically determine processing of ligand-encoded information. We show by mathematical modeling of quantitative data and experimental validation that rapid ligand depletion and replenishment of the cell surface receptor are characteristic features of the erythropoietin (Epo) receptor (EpoR). The amount of Epo-EpoR complexes and EpoR activation integrated over time corresponds linearly to ligand input; this process is carried out over a broad range of ligand concentrations. This relation depends solely on EpoR turnover independent of ligand binding, which suggests an essential role of large intracellular receptor pools. These receptor properties enable the system to cope with basal and acute demand in the hematopoietic system.

Owner

Hanne Nielsen <hnie010@aucklanduni.ac.nz>

URI for git clone/pull/push

https://models.physiomeproject.org/w/hnielsen/becker_2010

Report an issue with this workspace

Files