Modelling fluctuation phenomena in the plasma cortisol secretion system in normal man

Model Status

This CellML model runs in OpenCell and COR, and the units are consistent. The model is an accurate representation of the published model (equations 1a-1c), and runs to recreate the published results (figure 4). Parameter values were taken from the legend of figure 4.

Model Structure

ABSTRACT: A system of three non-linear differential equations with exponential feedback terms is proposed to model the self-regulating cortisol secretion system and explain the fluctuation patterns observed in clinical data. It is shown that the model exhibits bifurcation and chaos patterns for a certain range of parametric values. This helps us to explain clinical observations and characterize different dynamic behaviors of the self-regulative system.

The original paper reference is cited below:

Modelling fluctuation phenomena in the plasma cortisol secretion system in normal man, Yongwimon Lenbury and Pariwatana Pacheenburawana, 1991, BioSystems , 26, 117-125. PubMed ID: 1668715

Schematic diagram of the self-regulatory system for corticol secretion. CRH represents corticotropin-releasing hormone, ACTH is adrenocorticotropic hormone, and F represents cortisol. The red lines represent positive feedback pathways, while the blue lines represent negative feedback loops.