You are here: Home / Exposures / LeBeau, Yule, Groblewski, Sneyd, 1999 / Agonist-dependent Phosphorylation of the Inositol 1,4,5-Triphosphate Receptor

Model Mathematics

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Component: environment

Component: O

\frac{d}{d time} (O) = k1 p S - (k1_O + k2 O) S = 4.0 - (O + I1 + I2)

Component: I1

\frac{d}{d time} (I1) = k2 O - ((k3 + k4) I1)

Component: I2

\frac{d}{d time} (I2) = k4 I1 - (k5 I2)

Component: c

\frac{d}{d time} (c) = (J_rel - J_pump) + J_influx J_rel = k_flux O^{4.0} J_pump = \frac{V_p c^{2.0}}{{K_p}^{2.0} + c^{2.0}}

Component: constants

k1 = \frac{alpha_1 c^{3.0}}{{beta_1}^{3.0} + c^{3.0}} k4 = \frac{alpha_4 p}{beta_4 + p}

Source: Derived from workspace Lebeau, Yule, Groblewski, Sneyd, 1999 at changeset a00afd332a14.

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Agonist-dependent Phosphorylation of the Inositol 1,4,5-Triphosphate Receptor