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St Hilaire, Gronfier, Zeitzer, Klerman, 2007
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A physiologically based mathematical model of melatonin including ocular light suppression and interactions with the circadian pacemaker
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Model Mathematics
Component based math viewer is available
Component: environment
Component: H1
d
d
time
H1
=
-
betaIP
H1
+
A
Component: H2
d
d
time
H2
=
betaIP
H1
-
betaCP
H2
+
betaIS
H2
Component: H3
d
d
time
H3
=
betaIS
H2
-
betaCS
H3
Component: A
d
d
time
A
=
Amax
1.0
-
ⅇ
-
lamda
time
-
t_on
1.0
-
ⅇ
-
lamda
t_off
-
t_on
if
time
<
t_off
∨
time
≥
t_on
Amax
ⅇ
-
alpha
time
-
t_off
if
time
≥
t_off
d
d
time
A_
=
A
1.0
-
m
B_
Component: Process_L
alph
=
alph_0
I
I0
p
I
I
+
100.0
B_
=
G
1.0
-
n
alph
d
d
time
n
=
60.0
alph
1.0
-
n
-
beta
n
d
d
time
I
=
0.0
if
time
≥
0.0
∧
time
<
4.75
9500.0
if
time
≥
4.75
∧
time
<
11.2
0.0
otherwise
Component: Process_P
d
d
time
x
=
π
12.0
xc
+
mu
1.0
3.0
x
+
4.0
3.0
x
3.0
-
256.0
105.0
x
7.0
+
B
d
d
time
xc
=
π
12.0
q
B
xc
-
x
24.0
0.99729
tau_x
2.0
+
k
B
B
=
B_
1.0
-
0.4
x
1.0
-
0.4
xc
Component: model_parameters
Source
Derived from workspace
Sthilaire, Gronfier, Zeitzer, Klerman, 2007
at changeset
45f6c59cbe09
.
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License
This work is licensed under a
Creative Commons Attribution 3.0 Unported License
.
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A physiologically based mathematical model of melatonin including ocular light suppression and interactions with the circadian pacemaker