A Model of Cardiac Muscle Mechanics and Energetics

Model Status

This model is known to run in both OpenCell and COR. The units are consistent throughout, although it does not recreate all the published results. It contains a time delay, which was ignored in the model. This model simulates an isometric contraction.

Model Structure

Abstract: A model of cardiac muscle is proposed in which the contractile element is described by the sliding-filament theory of muscle contraction. The model is able to reproduce the time-varying patterns of tension, velocity of shortening, and muscle shortening as well as oxygen consumption of isometric or isotonic contractions. Quick releases can also be simulated in the model as well as changes in contractile state and initial muscle length. The results obtained with the model are in agreement with a wide range of experimental data concerning the mechanics and energetics of mammalian cardiac muscle.

Schematic diagram depicting the actin-myosin crossbrige cycle.

The original paper reference is cited below:

A Model of Cardiac Muscle Mechanics and Energetics, Ronney B. Panerai, 1980, Journal of Biomechanics, 13, 929-940. PubMed ID: 7276000