<?xml version="1.0"?>
<!--
This CellML file was generated on 23/01/2008 at 12:49:46 using:
COR (0.9.31.857)
Copyright 2002-2008 Dr Alan Garny
http://COR.physiol.ox.ac.uk/ - COR@physiol.ox.ac.uk
CellML 1.0 was used to generate this cellular model
http://www.CellML.org/
-->
<model xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bqs="http://www.cellml.org/bqs/1.0#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" name="shannon_2004" cmeta:id="shannon_2004" xmlns="http://www.cellml.org/cellml/1.0#" xmlns:cellml="http://www.cellml.org/cellml/1.0#" xmlns:cmeta="http://www.cellml.org/metadata/1.0#">
<documentation xmlns="http://cellml.org/tmp-documentation">
<article>
<articleinfo>
<title>A mathematical treatment of integrated Ca dynamics within the ventricular myocyte</title>
<author>
<firstname>Martin</firstname>
<surname>Fink</surname>
<affiliation>
<shortaffil>Oxford University</shortaffil>
</affiliation>
</author>
</articleinfo>
<section id="sec_status">
<title>Model Status</title>
<para>
This model runs in PCEnv, OpenCell and COR to recreate the published results. The units are consistent throughout. The model equations and output were checked using the original matlab code, and it currently recreates the Pace1 Stimulus protocol described.
</para>
</section>
<sect1 id="sec_structure">
<title>Model Structure</title>
<para>
ABSTRACT: We have developed a detailed mathematical model for Ca2+ handling and ionic currents in the rabbit ventricular myocyte. The objective was to develop a model that: 1), accurately reflects Ca-dependent Ca release; 2), uses realistic parameters, particularly those that concern Ca transport from the cytosol; 3), comes to steady state; 4), simulates basic excitation-contraction coupling phenomena; and 5), runs on a normal desktop computer. The model includes the following novel features: 1), the addition of a subsarcolemmal compartment to the other two commonly formulated cytosolic compartments (junctional and bulk) because ion channels in the membrane sense ion concentrations that differ from bulk; 2), the use of realistic cytosolic Ca buffering parameters; 3), a reversible sarcoplasmic reticulum (SR) Ca pump; 4), a scheme for Na-Ca exchange transport that is [Na]i dependent and allosterically regulated by [Ca]i; and 5), a practical model of SR Ca release including both inactivation/adaptation and SR Ca load dependence. The data describe normal electrical activity and Ca handling characteristics of the cardiac myocyte and the SR Ca load dependence of these processes. The model includes a realistic balance of Ca removal mechanisms (e.g., SR Ca pump versus Na-Ca exchange), and the phenomena of rest decay and frequency-dependent inotropy. A particular emphasis is placed upon reproducing the nonlinear dependence of gain and fractional SR Ca release upon SR Ca load. We conclude that this model is more robust than many previously existing models and reproduces many experimental results using parameters based largely on experimental measurements in myocytes.
</para>
<para>
The complete original paper reference is cited below:
</para>
<para>
A mathematical treatment of integrated Ca dynamics within the ventricular myocyte, Thomas R. Shannon, Fei Wang, Jose Puglisi, Christopher Weber and Donald M. Bers, 2004, <emphasis>Biophysical Journal</emphasis>, 87, 3351-3371. <ulink url="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=15347581&dopt=Abstract">PubMed ID: 15347581</ulink>
</para>
<informalfigure float="0" id="fig_cell_diagram">
<mediaobject>
<imageobject>
<objectinfo>
<title>cell diagram</title>
</objectinfo>
<imagedata fileref="shannon_2004.png"/>
</imageobject>
</mediaobject>
<caption>A schematic diagram of the cell model which highlights the calcium- and sodium-dependent components of the model in particular.</caption>
</informalfigure>
</sect1>
</article>
</documentation>
<units xmlns="http://www.cellml.org/cellml/1.0#" name="thou_mill">
<unit units="second" prefix="milli"/>
<unit units="second" exponent="-1"/>
</units>
<units xmlns="http://www.cellml.org/cellml/1.0#" name="centi2micro">
<unit units="metre" prefix="micro"/>
<unit units="metre" prefix="centi" exponent="-1"/>
</units>
<units xmlns="http://www.cellml.org/cellml/1.0#" name="millimolar_per_second">
<unit units="millimolar"/>
<unit units="second" exponent="-1"/>
</units>
<units xmlns="http://www.cellml.org/cellml/1.0#" name="per_millimolar_millisecond">
<unit units="millimolar" exponent="-1"/>
<unit units="second" prefix="milli" exponent="-1"/>
</units>
<units xmlns="http://www.cellml.org/cellml/1.0#" name="cm_per_second">
<unit units="metre" prefix="centi"/>
<unit units="second" exponent="-1"/>
</units>
<units xmlns="http://www.cellml.org/cellml/1.0#" name="per_second">
<unit units="second" exponent="-1"/>
</units>
<units xmlns="http://www.cellml.org/cellml/1.0#" name="per_millisecond">
<unit units="second" prefix="milli" exponent="-1"/>
</units>
<units xmlns="http://www.cellml.org/cellml/1.0#" name="litre_per_millisecond">
<unit units="litre"/>
<unit units="per_millisecond"/>
</units>
<units xmlns="http://www.cellml.org/cellml/1.0#" name="millivolt">
<unit units="volt" prefix="milli"/>
</units>
<units xmlns="http://www.cellml.org/cellml/1.0#" name="per_millivolt">
<unit units="volt" prefix="milli" exponent="-1"/>
</units>
<units xmlns="http://www.cellml.org/cellml/1.0#" name="millisecond">
<unit units="second" prefix="milli"/>
</units>
<units xmlns="http://www.cellml.org/cellml/1.0#" name="millimolar">
<unit units="mole" prefix="milli"/>
<unit units="litre" exponent="-1"/>
</units>
<units xmlns="http://www.cellml.org/cellml/1.0#" name="millimolar4">
<unit units="millimolar" exponent="4"/>
</units>
<units xmlns="http://www.cellml.org/cellml/1.0#" name="milliS_per_microF">
<unit units="siemens" prefix="milli"/>
<unit units="farad" prefix="micro" exponent="-1"/>
</units>
<units xmlns="http://www.cellml.org/cellml/1.0#" name="microF">
<unit units="farad" prefix="micro"/>
</units>
<units xmlns="http://www.cellml.org/cellml/1.0#" name="farad_per_cm2">
<unit units="farad"/>
<unit units="metre" prefix="centi" exponent="-2"/>
</units>
<units xmlns="http://www.cellml.org/cellml/1.0#" name="microA_per_microF">
<unit units="ampere" prefix="micro"/>
<unit units="farad" prefix="micro" exponent="-1"/>
</units>
<units xmlns="http://www.cellml.org/cellml/1.0#" name="millimole_per_millisecond">
<unit units="mole" prefix="milli"/>
<unit units="millisecond" exponent="-1"/>
</units>
<units xmlns="http://www.cellml.org/cellml/1.0#" name="millimolar_per_millisecond">
<unit units="millimolar"/>
<unit units="millisecond" exponent="-1"/>
</units>
<units xmlns="http://www.cellml.org/cellml/1.0#" name="dm2_per_second">
<unit units="meter" prefix="deci" exponent="2"/>
<unit units="second" exponent="-1"/>
</units>
<units xmlns="http://www.cellml.org/cellml/1.0#" name="per_millimolar_per_millisecond">
<unit units="millimolar" exponent="-1"/>
<unit units="second" prefix="milli" exponent="-1"/>
</units>
<units xmlns="http://www.cellml.org/cellml/1.0#" name="per_millimolar2_per_millisecond">
<unit units="millimolar" exponent="-2"/>
<unit units="second" prefix="milli" exponent="-1"/>
</units>
<units xmlns="http://www.cellml.org/cellml/1.0#" name="micrometre">
<unit units="metre" prefix="micro"/>
</units>
<units xmlns="http://www.cellml.org/cellml/1.0#" name="cm2">
<unit units="metre" prefix="centi" exponent="2"/>
</units>
<units xmlns="http://www.cellml.org/cellml/1.0#" name="nanolitre">
<unit units="litre" prefix="nano"/>
</units>
<units xmlns="http://www.cellml.org/cellml/1.0#" name="litre_per_farad_millisecond">
<unit units="litre"/>
<unit units="farad" exponent="-1"/>
<unit units="second" prefix="milli" exponent="-1"/>
</units>
<units xmlns="http://www.cellml.org/cellml/1.0#" name="joule_per_kilomole_kelvin">
<unit units="joule"/>
<unit units="mole" prefix="kilo" exponent="-1"/>
<unit units="kelvin" exponent="-1"/>
</units>
<units xmlns="http://www.cellml.org/cellml/1.0#" name="coulomb_per_mole">
<unit units="coulomb"/>
<unit units="mole" exponent="-1"/>
</units>
<component xmlns="http://www.cellml.org/cellml/1.0#" name="environment">
<variable cmeta:id="environment_time" name="time" units="millisecond" public_interface="out"/>
</component>
<component xmlns="http://www.cellml.org/cellml/1.0#" name="cell">
<variable cmeta:id="cell_V" name="V" units="millivolt" initial_value="-8.556885e1" public_interface="out"/>
<variable name="time" units="millisecond" public_interface="in"/>
<variable name="i_Na" units="microA_per_microF" public_interface="in"/>
<variable name="i_Nab" units="microA_per_microF" public_interface="in"/>
<variable name="i_NaK" units="microA_per_microF" public_interface="in"/>
<variable name="i_Kr" units="microA_per_microF" public_interface="in"/>
<variable name="i_Ks" units="microA_per_microF" public_interface="in"/>
<variable name="i_Kp" units="microA_per_microF" public_interface="in"/>
<variable name="i_tos" units="microA_per_microF" public_interface="in"/>
<variable name="i_tof" units="microA_per_microF" public_interface="in"/>
<variable name="i_K1" units="microA_per_microF" public_interface="in"/>
<variable name="i_NaCa" units="microA_per_microF" public_interface="in"/>
<variable name="i_Cl_Ca" units="microA_per_microF" public_interface="in"/>
<variable name="i_Clb" units="microA_per_microF" public_interface="in"/>
<variable name="i_CaL" units="microA_per_microF" public_interface="in"/>
<variable name="i_Cab" units="microA_per_microF" public_interface="in"/>
<variable name="i_Cap" units="microA_per_microF" public_interface="in"/>
<variable name="i_Stim" units="microA_per_microF"/>
<variable name="stim_start" units="millisecond" initial_value="100"/>
<variable name="stim_period" units="millisecond" initial_value="1000"/>
<variable name="stim_duration" units="millisecond" initial_value="5"/>
<variable name="stim_amplitude" units="microA_per_microF" initial_value="9.5"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>i_Stim</ci>
<piecewise>
<piece>
<apply>
<minus/>
<ci>stim_amplitude</ci>
</apply>
<apply>
<and/>
<apply>
<geq/>
<apply>
<minus/>
<ci>time</ci>
<apply>
<times/>
<apply>
<floor/>
<apply>
<divide/>
<ci>time</ci>
<ci>stim_period</ci>
</apply>
</apply>
<ci>stim_period</ci>
</apply>
</apply>
<ci>stim_start</ci>
</apply>
<apply>
<leq/>
<apply>
<minus/>
<ci>time</ci>
<apply>
<times/>
<apply>
<floor/>
<apply>
<divide/>
<ci>time</ci>
<ci>stim_period</ci>
</apply>
</apply>
<ci>stim_period</ci>
</apply>
</apply>
<apply>
<plus/>
<ci>stim_start</ci>
<ci>stim_duration</ci>
</apply>
</apply>
</apply>
</piece>
<otherwise>
<cn cellml:units="microA_per_microF">0</cn>
</otherwise>
</piecewise>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>V</ci>
</apply>
<apply>
<minus/>
<apply>
<plus/>
<ci>i_Na</ci>
<ci>i_Nab</ci>
<ci>i_NaK</ci>
<ci>i_Kr</ci>
<ci>i_Ks</ci>
<ci>i_tos</ci>
<ci>i_tof</ci>
<ci>i_K1</ci>
<ci>i_NaCa</ci>
<ci>i_Cl_Ca</ci>
<ci>i_Clb</ci>
<ci>i_CaL</ci>
<ci>i_Cab</ci>
<ci>i_Cap</ci>
<ci>i_Kp</ci>
<ci>i_Stim</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component xmlns="http://www.cellml.org/cellml/1.0#" name="model_parameters">
<variable name="Ko" units="millimolar" initial_value="5.4" public_interface="out"/>
<variable name="Nao" units="millimolar" initial_value="140" public_interface="out"/>
<variable name="Cao" units="millimolar" initial_value="1.8" public_interface="out"/>
<variable name="Clo" units="millimolar" initial_value="150" public_interface="out"/>
<variable name="Ki" units="millimolar" initial_value="135" public_interface="out"/>
<variable name="Mgi" units="millimolar" initial_value="1" public_interface="out"/>
<variable name="Cli" units="millimolar" initial_value="15" public_interface="out"/>
<variable name="R" units="joule_per_kilomole_kelvin" initial_value="8314.3" public_interface="out"/>
<variable name="T" units="kelvin" initial_value="310" public_interface="out"/>
<variable name="F" units="coulomb_per_mole" initial_value="96485" public_interface="out"/>
<variable name="Cm" units="farad" initial_value="1.381e-10" public_interface="out"/>
<variable name="cell_length" units="micrometre" initial_value="100"/>
<variable name="cell_radius" units="micrometre" initial_value="10.25"/>
<variable name="Vol_Cell" units="litre"/>
<variable name="Vol_SR" units="litre" public_interface="out"/>
<variable name="Vol_SL" units="litre" public_interface="out"/>
<variable name="Vol_jct" units="litre" public_interface="out"/>
<variable name="Vol_myo" units="litre" public_interface="out"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>Vol_Cell</ci>
<apply>
<divide/>
<apply>
<times/>
<cn cellml:units="dimensionless">3.141592654</cn>
<apply>
<power/>
<apply>
<divide/>
<ci>cell_radius</ci>
<cn cellml:units="thou_mill">1000</cn>
</apply>
<cn cellml:units="dimensionless">2</cn>
</apply>
<ci>cell_length</ci>
</apply>
<apply>
<power/>
<cn cellml:units="thou_mill">1000</cn>
<cn cellml:units="dimensionless">3</cn>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>Vol_SR</ci>
<apply>
<times/>
<cn cellml:units="dimensionless">0.035</cn>
<ci>Vol_Cell</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>Vol_SL</ci>
<apply>
<times/>
<cn cellml:units="dimensionless">0.02</cn>
<ci>Vol_Cell</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>Vol_jct</ci>
<apply>
<times/>
<cn cellml:units="dimensionless">0.0539</cn>
<cn cellml:units="dimensionless">0.01</cn>
<ci>Vol_Cell</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>Vol_myo</ci>
<apply>
<times/>
<cn cellml:units="dimensionless">0.65</cn>
<ci>Vol_Cell</ci>
</apply>
</apply>
</math>
</component>
<component xmlns="http://www.cellml.org/cellml/1.0#" name="reversal_potentials">
<variable name="E_Na_jct" units="millivolt" public_interface="out"/>
<variable name="E_Na_SL" units="millivolt" public_interface="out"/>
<variable name="E_Ca_jct" units="millivolt" public_interface="out"/>
<variable name="E_Ca_SL" units="millivolt" public_interface="out"/>
<variable name="E_K" units="millivolt" public_interface="out"/>
<variable name="E_Cl" units="millivolt" public_interface="out"/>
<variable name="R" units="joule_per_kilomole_kelvin" public_interface="in"/>
<variable name="T" units="kelvin" public_interface="in"/>
<variable name="F" units="coulomb_per_mole" public_interface="in"/>
<variable name="Nai" units="millimolar" public_interface="in"/>
<variable name="Na_jct" units="millimolar" public_interface="in"/>
<variable name="Na_SL" units="millimolar" public_interface="in"/>
<variable name="Nao" units="millimolar" public_interface="in"/>
<variable name="Cai" units="millimolar" public_interface="in"/>
<variable name="Ca_jct" units="millimolar" public_interface="in"/>
<variable name="Ca_SL" units="millimolar" public_interface="in"/>
<variable name="Cao" units="millimolar" public_interface="in"/>
<variable name="Ki" units="millimolar" public_interface="in"/>
<variable name="Ko" units="millimolar" public_interface="in"/>
<variable name="Cli" units="millimolar" public_interface="in"/>
<variable name="Clo" units="millimolar" public_interface="in"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>E_Na_jct</ci>
<apply>
<times/>
<apply>
<divide/>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
<ci>F</ci>
</apply>
<apply>
<ln/>
<apply>
<divide/>
<ci>Nao</ci>
<ci>Na_jct</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>E_Na_SL</ci>
<apply>
<times/>
<apply>
<divide/>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
<ci>F</ci>
</apply>
<apply>
<ln/>
<apply>
<divide/>
<ci>Nao</ci>
<ci>Na_SL</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>E_Ca_jct</ci>
<apply>
<times/>
<apply>
<divide/>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
<apply>
<times/>
<cn cellml:units="dimensionless">2</cn>
<ci>F</ci>
</apply>
</apply>
<apply>
<ln/>
<apply>
<divide/>
<ci>Cao</ci>
<ci>Ca_jct</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>E_Ca_SL</ci>
<apply>
<times/>
<apply>
<divide/>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
<apply>
<times/>
<cn cellml:units="dimensionless">2</cn>
<ci>F</ci>
</apply>
</apply>
<apply>
<ln/>
<apply>
<divide/>
<ci>Cao</ci>
<ci>Ca_SL</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>E_K</ci>
<apply>
<times/>
<apply>
<divide/>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
<ci>F</ci>
</apply>
<apply>
<ln/>
<apply>
<divide/>
<ci>Ko</ci>
<ci>Ki</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>E_Cl</ci>
<apply>
<times/>
<apply>
<divide/>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
<ci>F</ci>
</apply>
<apply>
<ln/>
<apply>
<divide/>
<ci>Cli</ci>
<ci>Clo</ci>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component xmlns="http://www.cellml.org/cellml/1.0#" name="INa">
<variable cmeta:id="INa_i_Na" name="i_Na" units="microA_per_microF" public_interface="out"/>
<variable name="i_Na_jct" units="microA_per_microF" public_interface="out"/>
<variable name="i_Na_SL" units="microA_per_microF" public_interface="out"/>
<variable name="G_INa" units="milliS_per_microF" initial_value="16"/>
<variable name="Fx_Na_jct" units="dimensionless" initial_value="0.11"/>
<variable name="Fx_Na_SL" units="dimensionless" initial_value="0.89"/>
<variable name="time" units="millisecond" public_interface="in" private_interface="out"/>
<variable name="V" units="millivolt" public_interface="in" private_interface="out"/>
<variable name="E_Na_jct" units="millivolt" public_interface="in"/>
<variable name="E_Na_SL" units="millivolt" public_interface="in"/>
<variable name="m" units="dimensionless" private_interface="in"/>
<variable name="h" units="dimensionless" private_interface="in"/>
<variable name="j" units="dimensionless" private_interface="in"/>
<variable name="openProb" units="dimensionless"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>openProb</ci>
<apply>
<times/>
<apply>
<power/>
<ci>m</ci>
<cn cellml:units="dimensionless">3</cn>
</apply>
<ci>h</ci>
<ci>j</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>i_Na_jct</ci>
<apply>
<times/>
<ci>Fx_Na_jct</ci>
<ci>G_INa</ci>
<ci>openProb</ci>
<apply>
<minus/>
<ci>V</ci>
<ci>E_Na_jct</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>i_Na_SL</ci>
<apply>
<times/>
<ci>Fx_Na_SL</ci>
<ci>G_INa</ci>
<ci>openProb</ci>
<apply>
<minus/>
<ci>V</ci>
<ci>E_Na_SL</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>i_Na</ci>
<apply>
<plus/>
<ci>i_Na_jct</ci>
<ci>i_Na_SL</ci>
</apply>
</apply>
</math>
</component>
<component xmlns="http://www.cellml.org/cellml/1.0#" name="INa_h_gate">
<variable name="h" units="dimensionless" initial_value="9.867005e-1" public_interface="out"/>
<variable name="alpha_h" units="per_millisecond"/>
<variable name="beta_h" units="per_millisecond"/>
<variable name="V" units="millivolt" public_interface="in"/>
<variable name="time" units="millisecond" public_interface="in"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>alpha_h</ci>
<piecewise>
<piece>
<apply>
<times/>
<cn cellml:units="per_millisecond">0.135</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<plus/>
<cn cellml:units="millivolt">80</cn>
<ci>V</ci>
</apply>
<apply>
<minus/>
<cn cellml:units="millivolt">6.8</cn>
</apply>
</apply>
</apply>
</apply>
<apply>
<lt/>
<ci>V</ci>
<apply>
<minus/>
<cn cellml:units="millivolt">40</cn>
</apply>
</apply>
</piece>
<otherwise>
<cn cellml:units="per_millisecond">0</cn>
</otherwise>
</piecewise>
</apply>
<apply>
<eq/>
<ci>beta_h</ci>
<piecewise>
<piece>
<apply>
<plus/>
<apply>
<times/>
<cn cellml:units="per_millisecond">3.56</cn>
<apply>
<exp/>
<apply>
<times/>
<cn cellml:units="per_millivolt">0.079</cn>
<ci>V</ci>
</apply>
</apply>
</apply>
<apply>
<times/>
<cn type="e-notation" cellml:units="per_millisecond">3.1 <sep/>
5</cn>
<apply>
<exp/>
<apply>
<times/>
<cn cellml:units="per_millivolt">0.35</cn>
<ci>V</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<lt/>
<ci>V</ci>
<apply>
<minus/>
<cn cellml:units="millivolt">40</cn>
</apply>
</apply>
</piece>
<otherwise>
<apply>
<divide/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<times/>
<cn cellml:units="millisecond">0.13</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="millivolt">10.66</cn>
</apply>
<apply>
<minus/>
<cn cellml:units="millivolt">11.1</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
</otherwise>
</piecewise>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>h</ci>
</apply>
<apply>
<minus/>
<apply>
<times/>
<ci>alpha_h</ci>
<apply>
<minus/>
<cn cellml:units="dimensionless">1</cn>
<ci>h</ci>
</apply>
</apply>
<apply>
<times/>
<ci>beta_h</ci>
<ci>h</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component xmlns="http://www.cellml.org/cellml/1.0#" name="INa_j_gate">
<variable name="j" units="dimensionless" initial_value="9.91562e-1" public_interface="out"/>
<variable name="alpha_j" units="per_millisecond"/>
<variable name="beta_j" units="per_millisecond"/>
<variable name="V" units="millivolt" public_interface="in"/>
<variable name="time" units="millisecond" public_interface="in"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>alpha_j</ci>
<piecewise>
<piece>
<apply>
<divide/>
<apply>
<divide/>
<apply>
<times/>
<apply>
<minus/>
<apply>
<times/>
<apply>
<minus/>
<cn type="e-notation" cellml:units="per_millisecond">1.2714 <sep/>
5</cn>
</apply>
<apply>
<exp/>
<apply>
<times/>
<cn cellml:units="per_millivolt">0.2444</cn>
<ci>V</ci>
</apply>
</apply>
</apply>
<apply>
<times/>
<cn type="e-notation" cellml:units="per_millisecond">3.474 <sep/>
-5</cn>
<apply>
<exp/>
<apply>
<times/>
<apply>
<minus/>
<cn cellml:units="per_millivolt">0.04391</cn>
</apply>
<ci>V</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="millivolt">37.78</cn>
</apply>
</apply>
<cn cellml:units="millivolt">1</cn>
</apply>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<times/>
<cn cellml:units="per_millivolt">0.311</cn>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="millivolt">79.23</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<lt/>
<ci>V</ci>
<apply>
<minus/>
<cn cellml:units="millivolt">40</cn>
</apply>
</apply>
</piece>
<otherwise>
<cn cellml:units="per_millisecond">0</cn>
</otherwise>
</piecewise>
</apply>
<apply>
<eq/>
<ci>beta_j</ci>
<piecewise>
<piece>
<apply>
<divide/>
<apply>
<times/>
<cn cellml:units="per_millisecond">0.1212</cn>
<apply>
<exp/>
<apply>
<times/>
<apply>
<minus/>
<cn cellml:units="per_millivolt">0.01052</cn>
</apply>
<ci>V</ci>
</apply>
</apply>
</apply>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<times/>
<apply>
<minus/>
<cn cellml:units="per_millivolt">0.1378</cn>
</apply>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="millivolt">40.14</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<lt/>
<ci>V</ci>
<apply>
<minus/>
<cn cellml:units="millivolt">40</cn>
</apply>
</apply>
</piece>
<otherwise>
<apply>
<divide/>
<apply>
<times/>
<cn cellml:units="per_millisecond">0.3</cn>
<apply>
<exp/>
<apply>
<times/>
<apply>
<minus/>
<cn type="e-notation" cellml:units="per_millivolt">2.535 <sep/>
-7</cn>
</apply>
<ci>V</ci>
</apply>
</apply>
</apply>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<times/>
<apply>
<minus/>
<cn cellml:units="per_millivolt">0.1</cn>
</apply>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="millivolt">32</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</otherwise>
</piecewise>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>j</ci>
</apply>
<apply>
<minus/>
<apply>
<times/>
<ci>alpha_j</ci>
<apply>
<minus/>
<cn cellml:units="dimensionless">1</cn>
<ci>j</ci>
</apply>
</apply>
<apply>
<times/>
<ci>beta_j</ci>
<ci>j</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component xmlns="http://www.cellml.org/cellml/1.0#" name="INa_m_gate">
<variable name="m" units="dimensionless" initial_value="1.405627e-3" public_interface="out"/>
<variable name="alpha_m" units="per_millisecond"/>
<variable name="beta_m" units="per_millisecond"/>
<variable name="V" units="millivolt" public_interface="in"/>
<variable name="time" units="millisecond" public_interface="in"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>alpha_m</ci>
<apply>
<divide/>
<apply>
<divide/>
<apply>
<times/>
<cn cellml:units="per_millisecond">0.32</cn>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="millivolt">47.13</cn>
</apply>
</apply>
<cn cellml:units="millivolt">1</cn>
</apply>
<apply>
<minus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<times/>
<apply>
<minus/>
<cn cellml:units="per_millivolt">0.1</cn>
</apply>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="millivolt">47.13</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>beta_m</ci>
<apply>
<times/>
<cn cellml:units="per_millisecond">0.08</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<ci>V</ci>
</apply>
<cn cellml:units="millivolt">11</cn>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>m</ci>
</apply>
<apply>
<minus/>
<apply>
<times/>
<ci>alpha_m</ci>
<apply>
<minus/>
<cn cellml:units="dimensionless">1</cn>
<ci>m</ci>
</apply>
</apply>
<apply>
<times/>
<ci>beta_m</ci>
<ci>m</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component xmlns="http://www.cellml.org/cellml/1.0#" name="INab">
<variable name="i_Nab" units="microA_per_microF" public_interface="out"/>
<variable name="i_Nab_jct" units="microA_per_microF" public_interface="out"/>
<variable name="i_Nab_SL" units="microA_per_microF" public_interface="out"/>
<variable name="G_NaBk" units="milliS_per_microF" initial_value="0.297e-3"/>
<variable name="Fx_NaBk_jct" units="dimensionless" initial_value="0.11"/>
<variable name="Fx_NaBk_SL" units="dimensionless" initial_value="0.89"/>
<variable name="V" units="millivolt" public_interface="in"/>
<variable name="E_Na_jct" units="millivolt" public_interface="in"/>
<variable name="E_Na_SL" units="millivolt" public_interface="in"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>i_Nab_jct</ci>
<apply>
<times/>
<ci>Fx_NaBk_jct</ci>
<ci>G_NaBk</ci>
<apply>
<minus/>
<ci>V</ci>
<ci>E_Na_jct</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>i_Nab_SL</ci>
<apply>
<times/>
<ci>Fx_NaBk_SL</ci>
<ci>G_NaBk</ci>
<apply>
<minus/>
<ci>V</ci>
<ci>E_Na_SL</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>i_Nab</ci>
<apply>
<plus/>
<ci>i_Nab_jct</ci>
<ci>i_Nab_SL</ci>
</apply>
</apply>
</math>
</component>
<component xmlns="http://www.cellml.org/cellml/1.0#" name="INaK">
<variable cmeta:id="INaK_i_NaK" name="i_NaK" units="microA_per_microF" public_interface="out"/>
<variable name="i_NaK_jct" units="microA_per_microF" public_interface="out"/>
<variable name="i_NaK_SL" units="microA_per_microF" public_interface="out"/>
<variable name="f_NaK" units="dimensionless"/>
<variable name="H_NaK" units="dimensionless" initial_value="4"/>
<variable name="Km_Nai" units="millimolar" initial_value="11"/>
<variable name="Km_Ko" units="millimolar" initial_value="1.5"/>
<variable name="I_NaK_max" units="microA_per_microF" initial_value="1.90719"/>
<variable name="sigma" units="dimensionless"/>
<variable name="Fx_NaK_jct" units="dimensionless" initial_value="0.11"/>
<variable name="Fx_NaK_SL" units="dimensionless" initial_value="0.89"/>
<variable name="V" units="millivolt" public_interface="in"/>
<variable name="R" units="joule_per_kilomole_kelvin" public_interface="in"/>
<variable name="T" units="kelvin" public_interface="in"/>
<variable name="F" units="coulomb_per_mole" public_interface="in"/>
<variable name="Nai" units="millimolar" public_interface="in"/>
<variable name="Na_jct" units="millimolar" public_interface="in"/>
<variable name="Na_SL" units="millimolar" public_interface="in"/>
<variable name="Nao" units="millimolar" public_interface="in"/>
<variable name="Ko" units="millimolar" public_interface="in"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>sigma</ci>
<apply>
<divide/>
<apply>
<minus/>
<apply>
<exp/>
<apply>
<divide/>
<ci>Nao</ci>
<cn cellml:units="millimolar">67.3</cn>
</apply>
</apply>
<cn cellml:units="dimensionless">1</cn>
</apply>
<cn cellml:units="dimensionless">7</cn>
</apply>
</apply>
<apply>
<eq/>
<ci>f_NaK</ci>
<apply>
<divide/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<times/>
<cn cellml:units="dimensionless">0.1245</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<times/>
<apply>
<minus/>
<cn cellml:units="dimensionless">0.1</cn>
</apply>
<ci>V</ci>
<ci>F</ci>
</apply>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<times/>
<cn cellml:units="dimensionless">0.0365</cn>
<ci>sigma</ci>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<times/>
<apply>
<minus/>
<ci>V</ci>
</apply>
<ci>F</ci>
</apply>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>i_NaK_jct</ci>
<apply>
<divide/>
<apply>
<times/>
<apply>
<divide/>
<apply>
<times/>
<ci>Fx_NaK_jct</ci>
<ci>I_NaK_max</ci>
<ci>f_NaK</ci>
</apply>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<power/>
<apply>
<divide/>
<ci>Km_Nai</ci>
<ci>Na_jct</ci>
</apply>
<ci>H_NaK</ci>
</apply>
</apply>
</apply>
<ci>Ko</ci>
</apply>
<apply>
<plus/>
<ci>Ko</ci>
<ci>Km_Ko</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>i_NaK_SL</ci>
<apply>
<divide/>
<apply>
<times/>
<apply>
<divide/>
<apply>
<times/>
<ci>Fx_NaK_SL</ci>
<ci>I_NaK_max</ci>
<ci>f_NaK</ci>
</apply>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<power/>
<apply>
<divide/>
<ci>Km_Nai</ci>
<ci>Na_SL</ci>
</apply>
<ci>H_NaK</ci>
</apply>
</apply>
</apply>
<ci>Ko</ci>
</apply>
<apply>
<plus/>
<ci>Ko</ci>
<ci>Km_Ko</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>i_NaK</ci>
<apply>
<plus/>
<ci>i_NaK_jct</ci>
<ci>i_NaK_SL</ci>
</apply>
</apply>
</math>
</component>
<component xmlns="http://www.cellml.org/cellml/1.0#" name="IKr">
<variable cmeta:id="IKr_i_Kr" name="i_Kr" units="microA_per_microF" public_interface="out"/>
<variable name="G_IKr" units="milliS_per_microF"/>
<variable name="time" units="millisecond" public_interface="in" private_interface="out"/>
<variable name="V" units="millivolt" public_interface="in" private_interface="out"/>
<variable name="E_K" units="millivolt" public_interface="in"/>
<variable name="Ko" units="millimolar" public_interface="in"/>
<variable name="Xr" units="dimensionless" private_interface="in"/>
<variable name="Rr" units="dimensionless" private_interface="in"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>G_IKr</ci>
<apply>
<times/>
<cn cellml:units="milliS_per_microF">0.03</cn>
<apply>
<root/>
<apply>
<divide/>
<ci>Ko</ci>
<cn cellml:units="millimolar">5.4</cn>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>i_Kr</ci>
<apply>
<times/>
<ci>G_IKr</ci>
<ci>Xr</ci>
<ci>Rr</ci>
<apply>
<minus/>
<ci>V</ci>
<ci>E_K</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component xmlns="http://www.cellml.org/cellml/1.0#" name="IKr_Xr_gate">
<variable name="Xr" units="dimensionless" initial_value="8.641386e-3" public_interface="out"/>
<variable name="Xr_infinity" units="dimensionless"/>
<variable name="tau_Xr" units="millisecond"/>
<variable name="V" units="millivolt" public_interface="in"/>
<variable name="time" units="millisecond" public_interface="in"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>Xr</ci>
</apply>
<apply>
<divide/>
<apply>
<minus/>
<ci>Xr_infinity</ci>
<ci>Xr</ci>
</apply>
<ci>tau_Xr</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>Xr_infinity</ci>
<apply>
<divide/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<apply>
<plus/>
<cn cellml:units="millivolt">50</cn>
<ci>V</ci>
</apply>
</apply>
<cn cellml:units="millivolt">7.5</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>tau_Xr</ci>
<apply>
<divide/>
<cn cellml:units="millisecond">1</cn>
<apply>
<plus/>
<apply>
<divide/>
<apply>
<times/>
<cn cellml:units="per_millivolt">0.00138</cn>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="millivolt">7</cn>
</apply>
</apply>
<apply>
<minus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<times/>
<apply>
<minus/>
<cn cellml:units="per_millivolt">0.123</cn>
</apply>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="millivolt">7</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<cn cellml:units="per_millivolt">0.00061</cn>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="millivolt">10</cn>
</apply>
</apply>
<apply>
<minus/>
<apply>
<exp/>
<apply>
<times/>
<cn cellml:units="per_millivolt">0.145</cn>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="millivolt">10</cn>
</apply>
</apply>
</apply>
<cn cellml:units="dimensionless">1</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component xmlns="http://www.cellml.org/cellml/1.0#" name="IKr_Rr_gate">
<variable name="Rr" units="dimensionless" public_interface="out"/>
<variable name="V" units="millivolt" public_interface="in"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>Rr</ci>
<apply>
<divide/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<plus/>
<cn cellml:units="millivolt">33</cn>
<ci>V</ci>
</apply>
<cn cellml:units="millivolt">22.4</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component xmlns="http://www.cellml.org/cellml/1.0#" name="IKs">
<variable cmeta:id="IKs_i_Ks" name="i_Ks" units="microA_per_microF" public_interface="out"/>
<variable name="i_Ks_jct" units="microA_per_microF"/>
<variable name="i_Ks_SL" units="microA_per_microF"/>
<variable name="G_Ks_SL" units="milliS_per_microF"/>
<variable name="G_Ks_jct" units="milliS_per_microF"/>
<variable name="Fx_Ks_jct" units="dimensionless" initial_value="0.11"/>
<variable name="Fx_Ks_SL" units="dimensionless" initial_value="0.89"/>
<variable name="E_Ks" units="millivolt"/>
<variable name="pKNa" units="dimensionless" initial_value="0.01833"/>
<variable name="pCa_jct" units="dimensionless"/>
<variable name="pCa_SL" units="dimensionless"/>
<variable name="R" units="joule_per_kilomole_kelvin" public_interface="in"/>
<variable name="T" units="kelvin" public_interface="in"/>
<variable name="F" units="coulomb_per_mole" public_interface="in"/>
<variable name="Nai" units="millimolar" public_interface="in"/>
<variable name="Nao" units="millimolar" public_interface="in"/>
<variable name="Ki" units="millimolar" public_interface="in"/>
<variable name="Ca_jct" units="millimolar" public_interface="in"/>
<variable name="Ca_SL" units="millimolar" public_interface="in"/>
<variable name="Ko" units="millimolar" public_interface="in"/>
<variable name="time" units="millisecond" public_interface="in" private_interface="out"/>
<variable name="V" units="millivolt" public_interface="in" private_interface="out"/>
<variable name="Xs" units="dimensionless" private_interface="in"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>pCa_jct</ci>
<apply>
<plus/>
<apply>
<minus/>
<apply>
<log/>
<apply>
<divide/>
<ci>Ca_jct</ci>
<cn cellml:units="millimolar">1</cn>
</apply>
</apply>
</apply>
<cn cellml:units="dimensionless">3</cn>
</apply>
</apply>
<apply>
<eq/>
<ci>pCa_SL</ci>
<apply>
<plus/>
<apply>
<minus/>
<apply>
<log/>
<apply>
<divide/>
<ci>Ca_SL</ci>
<cn cellml:units="millimolar">1</cn>
</apply>
</apply>
</apply>
<cn cellml:units="dimensionless">3</cn>
</apply>
</apply>
<apply>
<eq/>
<ci>G_Ks_jct</ci>
<apply>
<times/>
<cn cellml:units="milliS_per_microF">0.07</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">0.057</cn>
<apply>
<divide/>
<cn cellml:units="dimensionless">0.19</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<plus/>
<apply>
<minus/>
<cn cellml:units="dimensionless">7.2</cn>
</apply>
<ci>pCa_jct</ci>
</apply>
<cn cellml:units="dimensionless">0.6</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>G_Ks_SL</ci>
<apply>
<times/>
<cn cellml:units="milliS_per_microF">0.07</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">0.057</cn>
<apply>
<divide/>
<cn cellml:units="dimensionless">0.19</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<plus/>
<apply>
<minus/>
<cn cellml:units="dimensionless">7.2</cn>
</apply>
<ci>pCa_SL</ci>
</apply>
<cn cellml:units="dimensionless">0.6</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>E_Ks</ci>
<apply>
<times/>
<apply>
<divide/>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
<ci>F</ci>
</apply>
<apply>
<ln/>
<apply>
<divide/>
<apply>
<plus/>
<ci>Ko</ci>
<apply>
<times/>
<ci>pKNa</ci>
<ci>Nao</ci>
</apply>
</apply>
<apply>
<plus/>
<ci>Ki</ci>
<apply>
<times/>
<ci>pKNa</ci>
<ci>Nai</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>i_Ks_jct</ci>
<apply>
<times/>
<ci>Fx_Ks_jct</ci>
<ci>G_Ks_jct</ci>
<apply>
<power/>
<ci>Xs</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
<apply>
<minus/>
<ci>V</ci>
<ci>E_Ks</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>i_Ks_SL</ci>
<apply>
<times/>
<ci>Fx_Ks_SL</ci>
<ci>G_Ks_SL</ci>
<apply>
<power/>
<ci>Xs</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
<apply>
<minus/>
<ci>V</ci>
<ci>E_Ks</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>i_Ks</ci>
<apply>
<plus/>
<ci>i_Ks_jct</ci>
<ci>i_Ks_SL</ci>
</apply>
</apply>
</math>
</component>
<component xmlns="http://www.cellml.org/cellml/1.0#" name="IKs_Xs_gate">
<variable name="Xs" units="dimensionless" initial_value="5.412034e-3" public_interface="out"/>
<variable name="Xs_infinity" units="dimensionless"/>
<variable name="tau_Xs" units="millisecond"/>
<variable name="V" units="millivolt" public_interface="in"/>
<variable name="time" units="millisecond" public_interface="in"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>Xs</ci>
</apply>
<apply>
<divide/>
<apply>
<minus/>
<ci>Xs_infinity</ci>
<ci>Xs</ci>
</apply>
<ci>tau_Xs</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>Xs_infinity</ci>
<apply>
<divide/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<apply>
<minus/>
<ci>V</ci>
<cn cellml:units="millivolt">1.5</cn>
</apply>
</apply>
<cn cellml:units="millivolt">16.7</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>tau_Xs</ci>
<apply>
<divide/>
<cn cellml:units="millisecond">1</cn>
<apply>
<plus/>
<apply>
<divide/>
<apply>
<times/>
<cn type="e-notation" cellml:units="per_millivolt">7.19 <sep/>
-5</cn>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="millivolt">30</cn>
</apply>
</apply>
<apply>
<minus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<times/>
<apply>
<minus/>
<cn cellml:units="per_millivolt">0.148</cn>
</apply>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="millivolt">30</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<cn type="e-notation" cellml:units="per_millivolt">1.31 <sep/>
-4</cn>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="millivolt">30</cn>
</apply>
</apply>
<apply>
<plus/>
<apply>
<minus/>
<cn cellml:units="dimensionless">1</cn>
</apply>
<apply>
<exp/>
<apply>
<times/>
<cn cellml:units="per_millivolt">0.0687</cn>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="millivolt">30</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component xmlns="http://www.cellml.org/cellml/1.0#" name="IKp">
<variable name="i_Kp" units="microA_per_microF" public_interface="out"/>
<variable name="E_K" units="millivolt" public_interface="in"/>
<variable name="V" units="millivolt" public_interface="in"/>
<variable name="g_Kp" units="milliS_per_microF" initial_value="0.001"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>i_Kp</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>g_Kp</ci>
<apply>
<minus/>
<ci>V</ci>
<ci>E_K</ci>
</apply>
</apply>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<minus/>
<cn cellml:units="dimensionless">7.488</cn>
<apply>
<divide/>
<ci>V</ci>
<cn cellml:units="millivolt">5.98</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component xmlns="http://www.cellml.org/cellml/1.0#" name="Itos">
<variable name="i_tos" units="microA_per_microF" public_interface="out"/>
<variable name="G_tos" units="milliS_per_microF" initial_value="0.06"/>
<variable name="V" units="millivolt" public_interface="in" private_interface="out"/>
<variable name="time" units="millisecond" public_interface="in" private_interface="out"/>
<variable name="E_K" units="millivolt" public_interface="in"/>
<variable name="Y_tos" units="dimensionless" private_interface="in"/>
<variable name="X_tos" units="dimensionless" private_interface="in"/>
<variable name="R_tos" units="dimensionless" private_interface="in"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>i_tos</ci>
<apply>
<times/>
<ci>G_tos</ci>
<ci>X_tos</ci>
<apply>
<plus/>
<ci>Y_tos</ci>
<apply>
<times/>
<cn cellml:units="dimensionless">0.5</cn>
<ci>R_tos</ci>
</apply>
</apply>
<apply>
<minus/>
<ci>V</ci>
<ci>E_K</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component xmlns="http://www.cellml.org/cellml/1.0#" name="Itos_X_gate">
<variable name="X_tos" units="dimensionless" initial_value="4.051574e-3" public_interface="out"/>
<variable name="X_tos_infinity" units="dimensionless"/>
<variable name="tau_X_tos" units="millisecond"/>
<variable name="V" units="millivolt" public_interface="in"/>
<variable name="time" units="millisecond" public_interface="in"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>X_tos</ci>
</apply>
<apply>
<divide/>
<apply>
<minus/>
<ci>X_tos_infinity</ci>
<ci>X_tos</ci>
</apply>
<ci>tau_X_tos</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>X_tos_infinity</ci>
<apply>
<divide/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="millivolt">3</cn>
</apply>
</apply>
<cn cellml:units="millivolt">15</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>tau_X_tos</ci>
<apply>
<plus/>
<apply>
<divide/>
<cn cellml:units="millisecond">9</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="millivolt">3</cn>
</apply>
<cn cellml:units="millivolt">15</cn>
</apply>
</apply>
</apply>
</apply>
<cn cellml:units="millisecond">0.5</cn>
</apply>
</apply>
</math>
</component>
<component xmlns="http://www.cellml.org/cellml/1.0#" name="Itos_Y_gate">
<variable name="Y_tos" units="dimensionless" initial_value="9.945511e-1" public_interface="out"/>
<variable name="Y_tos_infinity" units="dimensionless"/>
<variable name="tau_Y_tos" units="millisecond"/>
<variable name="V" units="millivolt" public_interface="in"/>
<variable name="time" units="millisecond" public_interface="in"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>Y_tos</ci>
</apply>
<apply>
<divide/>
<apply>
<minus/>
<ci>Y_tos_infinity</ci>
<ci>Y_tos</ci>
</apply>
<ci>tau_Y_tos</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>Y_tos_infinity</ci>
<apply>
<divide/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="millivolt">33.5</cn>
</apply>
<cn cellml:units="millivolt">10</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>tau_Y_tos</ci>
<apply>
<plus/>
<apply>
<divide/>
<cn cellml:units="millisecond">3000</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="millivolt">60</cn>
</apply>
<cn cellml:units="millivolt">10</cn>
</apply>
</apply>
</apply>
</apply>
<cn cellml:units="millisecond">30</cn>
</apply>
</apply>
</math>
</component>
<component xmlns="http://www.cellml.org/cellml/1.0#" name="Itos_R_gate">
<variable name="R_tos" units="dimensionless" initial_value="0.9946" public_interface="out"/>
<variable name="R_tos_infinity" units="dimensionless"/>
<variable name="V" units="millivolt" public_interface="in"/>
<variable name="tau_R_tos" units="millisecond"/>
<variable name="time" units="millisecond" public_interface="in"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>R_tos_infinity</ci>
<apply>
<divide/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="millivolt">33.5</cn>
</apply>
<cn cellml:units="millivolt">10</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>tau_R_tos</ci>
<apply>
<plus/>
<apply>
<divide/>
<cn type="e-notation" cellml:units="millisecond">2.8 <sep/>
3</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="millivolt">60</cn>
</apply>
<cn cellml:units="millivolt">10</cn>
</apply>
</apply>
</apply>
</apply>
<cn cellml:units="millisecond">220</cn>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>R_tos</ci>
</apply>
<apply>
<divide/>
<apply>
<minus/>
<ci>R_tos_infinity</ci>
<ci>R_tos</ci>
</apply>
<ci>tau_R_tos</ci>
</apply>
</apply>
</math>
</component>
<component xmlns="http://www.cellml.org/cellml/1.0#" name="Itof">
<variable cmeta:id="Itof_i_tof" name="i_tof" units="microA_per_microF" public_interface="out"/>
<variable name="G_tof" units="milliS_per_microF" initial_value="0.02"/>
<variable name="V" units="millivolt" public_interface="in" private_interface="out"/>
<variable name="time" units="millisecond" public_interface="in" private_interface="out"/>
<variable name="E_K" units="millivolt" public_interface="in"/>
<variable name="Y_tof" units="dimensionless" private_interface="in"/>
<variable name="X_tof" units="dimensionless" private_interface="in"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>i_tof</ci>
<apply>
<times/>
<ci>G_tof</ci>
<ci>X_tof</ci>
<ci>Y_tof</ci>
<apply>
<minus/>
<ci>V</ci>
<ci>E_K</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component xmlns="http://www.cellml.org/cellml/1.0#" name="Itof_X_gate">
<variable name="X_tof" units="dimensionless" initial_value="4.051574e-3" public_interface="out"/>
<variable name="X_tof_infinity" units="dimensionless"/>
<variable name="tau_X_tof" units="millisecond"/>
<variable name="V" units="millivolt" public_interface="in"/>
<variable name="time" units="millisecond" public_interface="in"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>X_tof</ci>
</apply>
<apply>
<divide/>
<apply>
<minus/>
<ci>X_tof_infinity</ci>
<ci>X_tof</ci>
</apply>
<ci>tau_X_tof</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>X_tof_infinity</ci>
<apply>
<divide/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="millivolt">3</cn>
</apply>
</apply>
<cn cellml:units="millivolt">15</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>tau_X_tof</ci>
<apply>
<plus/>
<apply>
<times/>
<cn cellml:units="millisecond">3.5</cn>
<apply>
<exp/>
<apply>
<minus/>
<apply>
<power/>
<apply>
<divide/>
<ci>V</ci>
<cn cellml:units="millivolt">30</cn>
</apply>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
</apply>
<cn cellml:units="millisecond">1.5</cn>
</apply>
</apply>
</math>
</component>
<component xmlns="http://www.cellml.org/cellml/1.0#" name="Itof_Y_gate">
<variable name="Y_tof" units="dimensionless" initial_value="9.945511e-1" public_interface="out"/>
<variable name="Y_tof_infinity" units="dimensionless"/>
<variable name="tau_Y_tof" units="millisecond"/>
<variable name="V" units="millivolt" public_interface="in"/>
<variable name="time" units="millisecond" public_interface="in"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>Y_tof</ci>
</apply>
<apply>
<divide/>
<apply>
<minus/>
<ci>Y_tof_infinity</ci>
<ci>Y_tof</ci>
</apply>
<ci>tau_Y_tof</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>Y_tof_infinity</ci>
<apply>
<divide/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="millivolt">33.5</cn>
</apply>
<cn cellml:units="millivolt">10</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>tau_Y_tof</ci>
<apply>
<plus/>
<apply>
<divide/>
<cn cellml:units="millisecond">20</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="millivolt">33.5</cn>
</apply>
<cn cellml:units="millivolt">10</cn>
</apply>
</apply>
</apply>
</apply>
<cn cellml:units="millisecond">20</cn>
</apply>
</apply>
</math>
</component>
<component xmlns="http://www.cellml.org/cellml/1.0#" name="IK1">
<variable cmeta:id="IK1_i_K1" name="i_K1" units="microA_per_microF" public_interface="out"/>
<variable name="G_K1" units="milliS_per_microF"/>
<variable name="V" units="millivolt" public_interface="in" private_interface="out"/>
<variable name="E_K" units="millivolt" public_interface="in" private_interface="out"/>
<variable name="Ko" units="millimolar" public_interface="in"/>
<variable name="K1_infinity" units="dimensionless" private_interface="in"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>G_K1</ci>
<apply>
<times/>
<cn cellml:units="milliS_per_microF">0.9</cn>
<apply>
<root/>
<apply>
<divide/>
<ci>Ko</ci>
<cn cellml:units="millimolar">5.4</cn>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>i_K1</ci>
<apply>
<times/>
<ci>G_K1</ci>
<ci>K1_infinity</ci>
<apply>
<minus/>
<ci>V</ci>
<ci>E_K</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component xmlns="http://www.cellml.org/cellml/1.0#" name="IK1_K1_gate">
<variable name="K1_infinity" units="dimensionless" public_interface="out"/>
<variable name="alpha_K1" units="per_millisecond"/>
<variable name="beta_K1" units="per_millisecond"/>
<variable name="E_K" units="millivolt" public_interface="in"/>
<variable name="V" units="millivolt" public_interface="in"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>K1_infinity</ci>
<apply>
<divide/>
<ci>alpha_K1</ci>
<apply>
<plus/>
<ci>alpha_K1</ci>
<ci>beta_K1</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>alpha_K1</ci>
<apply>
<divide/>
<cn cellml:units="per_millisecond">1.02</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<times/>
<cn cellml:units="per_millivolt">0.2385</cn>
<apply>
<minus/>
<ci>V</ci>
<apply>
<plus/>
<ci>E_K</ci>
<cn cellml:units="millivolt">59.215</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>beta_K1</ci>
<apply>
<divide/>
<apply>
<plus/>
<apply>
<times/>
<cn cellml:units="per_millisecond">0.49124</cn>
<apply>
<exp/>
<apply>
<times/>
<cn cellml:units="per_millivolt">0.08032</cn>
<apply>
<plus/>
<apply>
<minus/>
<ci>V</ci>
<ci>E_K</ci>
</apply>
<cn cellml:units="millivolt">5.476</cn>
</apply>
</apply>
</apply>
</apply>
<apply>
<times/>
<cn cellml:units="per_millisecond">1</cn>
<apply>
<exp/>
<apply>
<times/>
<cn cellml:units="per_millivolt">0.06175</cn>
<apply>
<minus/>
<ci>V</ci>
<apply>
<plus/>
<ci>E_K</ci>
<cn cellml:units="millivolt">594.31</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<times/>
<apply>
<minus/>
<cn cellml:units="per_millivolt">0.5143</cn>
</apply>
<apply>
<plus/>
<apply>
<minus/>
<ci>V</ci>
<ci>E_K</ci>
</apply>
<cn cellml:units="millivolt">4.753</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component xmlns="http://www.cellml.org/cellml/1.0#" name="ICl_Ca">
<variable cmeta:id="ICl_Ca_i_Cl_Ca" name="i_Cl_Ca" units="microA_per_microF" public_interface="out"/>
<variable name="G_Cl" units="milliS_per_microF" initial_value="0.109625"/>
<variable name="Kd_ClCa" units="millimolar" initial_value="0.1"/>
<variable name="Fx_Cl_jct" units="dimensionless" initial_value="0.11"/>
<variable name="Fx_Cl_SL" units="dimensionless" initial_value="0.89"/>
<variable name="V" units="millivolt" public_interface="in"/>
<variable name="E_Cl" units="millivolt" public_interface="in"/>
<variable name="Ca_jct" units="millimolar" public_interface="in"/>
<variable name="Ca_SL" units="millimolar" public_interface="in"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>i_Cl_Ca</ci>
<apply>
<times/>
<ci>G_Cl</ci>
<apply>
<minus/>
<ci>V</ci>
<ci>E_Cl</ci>
</apply>
<apply>
<plus/>
<apply>
<divide/>
<ci>Fx_Cl_jct</ci>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>Kd_ClCa</ci>
<ci>Ca_jct</ci>
</apply>
</apply>
</apply>
<apply>
<divide/>
<ci>Fx_Cl_SL</ci>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>Kd_ClCa</ci>
<ci>Ca_SL</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component xmlns="http://www.cellml.org/cellml/1.0#" name="IClb">
<variable name="i_Clb" units="microA_per_microF" public_interface="out"/>
<variable name="G_ClBk" units="milliS_per_microF" initial_value="0.009"/>
<variable name="V" units="millivolt" public_interface="in"/>
<variable name="E_Cl" units="millivolt" public_interface="in"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>i_Clb</ci>
<apply>
<times/>
<ci>G_ClBk</ci>
<apply>
<minus/>
<ci>V</ci>
<ci>E_Cl</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component xmlns="http://www.cellml.org/cellml/1.0#" name="ICaL">
<variable cmeta:id="ICaL_i_CaL" name="i_CaL" units="microA_per_microF" public_interface="out"/>
<variable name="i_CaL_Ca_SL" units="microA_per_microF" public_interface="out"/>
<variable name="i_CaL_Ca_jct" units="microA_per_microF" public_interface="out"/>
<variable name="i_CaL_Na_SL" units="microA_per_microF" public_interface="out"/>
<variable name="i_CaL_Na_jct" units="microA_per_microF" public_interface="out"/>
<variable name="i_CaL_K" units="microA_per_microF"/>
<variable name="PCa" units="litre_per_farad_millisecond" initial_value="5.4e-4"/>
<variable name="PNa" units="litre_per_farad_millisecond" initial_value="1.5e-8"/>
<variable name="PK" units="litre_per_farad_millisecond" initial_value="2.7e-7"/>
<variable name="Fx_ICaL_jct" units="dimensionless" initial_value="0.9"/>
<variable name="Fx_ICaL_SL" units="dimensionless" initial_value="0.1"/>
<variable name="gamma_Cai" units="dimensionless" initial_value="0.341"/>
<variable name="gamma_Cao" units="dimensionless" initial_value="0.341"/>
<variable name="gamma_Nai" units="dimensionless" initial_value="0.75"/>
<variable name="gamma_Nao" units="dimensionless" initial_value="0.75"/>
<variable name="gamma_Ki" units="dimensionless" initial_value="0.75"/>
<variable name="gamma_Ko" units="dimensionless" initial_value="0.75"/>
<variable name="Q10_CaL" units="dimensionless" initial_value="1.8"/>
<variable name="Q_CaL" units="dimensionless"/>
<variable name="V" units="millivolt" public_interface="in" private_interface="out"/>
<variable name="time" units="millisecond" public_interface="in" private_interface="out"/>
<variable name="Cai" units="millimolar" public_interface="in" private_interface="out"/>
<variable name="Na_SL" units="millimolar" public_interface="in"/>
<variable name="Na_jct" units="millimolar" public_interface="in"/>
<variable name="Nao" units="millimolar" public_interface="in"/>
<variable name="Ca_SL" units="millimolar" public_interface="in" private_interface="out"/>
<variable name="Ca_jct" units="millimolar" public_interface="in" private_interface="out"/>
<variable name="Cao" units="millimolar" public_interface="in"/>
<variable name="Ki" units="millimolar" public_interface="in"/>
<variable name="Ko" units="millimolar" public_interface="in"/>
<variable name="R" units="joule_per_kilomole_kelvin" public_interface="in"/>
<variable name="T" units="kelvin" public_interface="in"/>
<variable name="F" units="coulomb_per_mole" public_interface="in"/>
<variable name="d" units="dimensionless" private_interface="in"/>
<variable name="f" units="dimensionless" private_interface="in"/>
<variable name="fCa_SL" units="dimensionless" private_interface="in"/>
<variable name="fCa_jct" units="dimensionless" private_interface="in"/>
<variable name="temp" units="coulomb_per_mole"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>Q_CaL</ci>
<apply>
<power/>
<ci>Q10_CaL</ci>
<apply>
<divide/>
<apply>
<minus/>
<ci>T</ci>
<cn cellml:units="kelvin">310</cn>
</apply>
<cn cellml:units="kelvin">10</cn>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>temp</ci>
<apply>
<divide/>
<apply>
<times/>
<cn cellml:units="dimensionless">0.45</cn>
<ci>d</ci>
<ci>f</ci>
<ci>Q_CaL</ci>
<ci>V</ci>
<apply>
<power/>
<ci>F</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>i_CaL_Ca_jct</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>temp</ci>
<ci>fCa_jct</ci>
<ci>Fx_ICaL_jct</ci>
<ci>PCa</ci>
<cn cellml:units="dimensionless">4</cn>
<apply>
<minus/>
<apply>
<times/>
<ci>gamma_Cai</ci>
<ci>Ca_jct</ci>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<times/>
<cn cellml:units="dimensionless">2</cn>
<ci>V</ci>
<ci>F</ci>
</apply>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<times/>
<ci>gamma_Cao</ci>
<ci>Cao</ci>
</apply>
</apply>
</apply>
<apply>
<minus/>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<times/>
<cn cellml:units="dimensionless">2</cn>
<ci>V</ci>
<ci>F</ci>
</apply>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
<cn cellml:units="dimensionless">1</cn>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>i_CaL_Na_jct</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>temp</ci>
<ci>fCa_jct</ci>
<ci>Fx_ICaL_jct</ci>
<ci>PNa</ci>
<apply>
<minus/>
<apply>
<times/>
<ci>gamma_Nai</ci>
<ci>Na_jct</ci>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<times/>
<ci>V</ci>
<ci>F</ci>
</apply>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<times/>
<ci>gamma_Nao</ci>
<ci>Nao</ci>
</apply>
</apply>
</apply>
<apply>
<minus/>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<times/>
<ci>V</ci>
<ci>F</ci>
</apply>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
<cn cellml:units="dimensionless">1</cn>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>i_CaL_Ca_SL</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>temp</ci>
<ci>fCa_SL</ci>
<ci>Fx_ICaL_SL</ci>
<ci>PCa</ci>
<cn cellml:units="dimensionless">4</cn>
<apply>
<minus/>
<apply>
<times/>
<ci>gamma_Cai</ci>
<ci>Ca_SL</ci>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<times/>
<cn cellml:units="dimensionless">2</cn>
<ci>V</ci>
<ci>F</ci>
</apply>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<times/>
<ci>gamma_Cao</ci>
<ci>Cao</ci>
</apply>
</apply>
</apply>
<apply>
<minus/>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<times/>
<cn cellml:units="dimensionless">2</cn>
<ci>V</ci>
<ci>F</ci>
</apply>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
<cn cellml:units="dimensionless">1</cn>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>i_CaL_Na_SL</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>temp</ci>
<ci>fCa_SL</ci>
<ci>Fx_ICaL_SL</ci>
<ci>PNa</ci>
<apply>
<minus/>
<apply>
<times/>
<ci>gamma_Nai</ci>
<ci>Na_SL</ci>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<times/>
<ci>V</ci>
<ci>F</ci>
</apply>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<times/>
<ci>gamma_Nao</ci>
<ci>Nao</ci>
</apply>
</apply>
</apply>
<apply>
<minus/>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<times/>
<ci>V</ci>
<ci>F</ci>
</apply>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
<cn cellml:units="dimensionless">1</cn>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>i_CaL_K</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>temp</ci>
<apply>
<plus/>
<apply>
<times/>
<ci>fCa_SL</ci>
<ci>Fx_ICaL_SL</ci>
</apply>
<apply>
<times/>
<ci>fCa_jct</ci>
<ci>Fx_ICaL_jct</ci>
</apply>
</apply>
<ci>PK</ci>
<apply>
<minus/>
<apply>
<times/>
<ci>gamma_Ki</ci>
<ci>Ki</ci>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<times/>
<ci>V</ci>
<ci>F</ci>
</apply>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<times/>
<ci>gamma_Ko</ci>
<ci>Ko</ci>
</apply>
</apply>
</apply>
<apply>
<minus/>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<times/>
<ci>V</ci>
<ci>F</ci>
</apply>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
<cn cellml:units="dimensionless">1</cn>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>i_CaL</ci>
<apply>
<plus/>
<ci>i_CaL_Ca_SL</ci>
<ci>i_CaL_Ca_jct</ci>
<ci>i_CaL_Na_SL</ci>
<ci>i_CaL_Na_jct</ci>
<ci>i_CaL_K</ci>
</apply>
</apply>
</math>
</component>
<component xmlns="http://www.cellml.org/cellml/1.0#" name="ICaL_d_gate">
<variable name="d" units="dimensionless" initial_value="7.175662e-6" public_interface="out"/>
<variable name="d_infinity" units="dimensionless"/>
<variable name="tau_d" units="millisecond"/>
<variable name="V" units="millivolt" public_interface="in"/>
<variable name="time" units="millisecond" public_interface="in"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>d_infinity</ci>
<apply>
<divide/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="millivolt">14.5</cn>
</apply>
</apply>
<cn cellml:units="millivolt">6</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>tau_d</ci>
<apply>
<divide/>
<apply>
<times/>
<cn cellml:units="millisecond">1</cn>
<ci>d_infinity</ci>
<apply>
<minus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="millivolt">14.5</cn>
</apply>
</apply>
<cn cellml:units="millivolt">6</cn>
</apply>
</apply>
</apply>
</apply>
<apply>
<times/>
<cn cellml:units="per_millivolt">0.035</cn>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="millivolt">14.5</cn>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>d</ci>
</apply>
<apply>
<divide/>
<apply>
<minus/>
<ci>d_infinity</ci>
<ci>d</ci>
</apply>
<ci>tau_d</ci>
</apply>
</apply>
</math>
</component>
<component xmlns="http://www.cellml.org/cellml/1.0#" name="ICaL_f_gate">
<variable name="f" units="dimensionless" initial_value="1.000681" public_interface="out"/>
<variable name="f_infinity" units="dimensionless"/>
<variable name="tau_f" units="millisecond"/>
<variable name="V" units="millivolt" public_interface="in"/>
<variable name="time" units="millisecond" public_interface="in"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>f_infinity</ci>
<apply>
<plus/>
<apply>
<divide/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="millivolt">35.06</cn>
</apply>
<cn cellml:units="millivolt">3.6</cn>
</apply>
</apply>
</apply>
</apply>
<apply>
<divide/>
<cn cellml:units="dimensionless">0.6</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<cn cellml:units="millivolt">50</cn>
<ci>V</ci>
</apply>
<cn cellml:units="millivolt">20</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>tau_f</ci>
<apply>
<divide/>
<cn cellml:units="millisecond">1</cn>
<apply>
<plus/>
<apply>
<times/>
<cn cellml:units="dimensionless">0.0197</cn>
<apply>
<exp/>
<apply>
<minus/>
<apply>
<power/>
<apply>
<times/>
<cn cellml:units="per_millivolt">0.0337</cn>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="millivolt">14.5</cn>
</apply>
</apply>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
</apply>
<cn cellml:units="dimensionless">0.02</cn>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>f</ci>
</apply>
<apply>
<divide/>
<apply>
<minus/>
<ci>f_infinity</ci>
<ci>f</ci>
</apply>
<ci>tau_f</ci>
</apply>
</apply>
</math>
</component>
<component xmlns="http://www.cellml.org/cellml/1.0#" name="ICaL_fCa_gate">
<variable name="fCa_SL" units="dimensionless" public_interface="out"/>
<variable name="fCa_jct" units="dimensionless" public_interface="out"/>
<variable name="fCaB_SL" units="dimensionless" initial_value="1.452605e-2" public_interface="out"/>
<variable name="fCaB_jct" units="dimensionless" initial_value="2.421991e-2" public_interface="out"/>
<variable name="Ca_SL" units="millimolar" public_interface="in"/>
<variable name="Ca_jct" units="millimolar" public_interface="in"/>
<variable name="time" units="millisecond" public_interface="in"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>fCa_SL</ci>
<apply>
<minus/>
<cn cellml:units="dimensionless">1</cn>
<ci>fCaB_SL</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>fCa_jct</ci>
<apply>
<minus/>
<cn cellml:units="dimensionless">1</cn>
<ci>fCaB_jct</ci>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>fCaB_SL</ci>
</apply>
<apply>
<minus/>
<apply>
<times/>
<cn cellml:units="per_millimolar_millisecond">1.7</cn>
<ci>Ca_SL</ci>
<apply>
<minus/>
<cn cellml:units="dimensionless">1</cn>
<ci>fCaB_SL</ci>
</apply>
</apply>
<apply>
<times/>
<cn type="e-notation" cellml:units="per_millisecond">11.9 <sep/>
-3</cn>
<ci>fCaB_SL</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>fCaB_jct</ci>
</apply>
<apply>
<minus/>
<apply>
<times/>
<cn cellml:units="per_millimolar_millisecond">1.7</cn>
<ci>Ca_jct</ci>
<apply>
<minus/>
<cn cellml:units="dimensionless">1</cn>
<ci>fCaB_jct</ci>
</apply>
</apply>
<apply>
<times/>
<cn type="e-notation" cellml:units="per_millisecond">11.9 <sep/>
-3</cn>
<ci>fCaB_jct</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component xmlns="http://www.cellml.org/cellml/1.0#" name="INaCa">
<variable cmeta:id="INaCa_i_NaCa" name="i_NaCa" units="microA_per_microF" public_interface="out"/>
<variable name="i_NaCa_SL" units="microA_per_microF" public_interface="out"/>
<variable name="i_NaCa_jct" units="microA_per_microF" public_interface="out"/>
<variable name="V_max" units="microA_per_microF" initial_value="9"/>
<variable name="Fx_NCX_jct" units="dimensionless" initial_value="0.11"/>
<variable name="Fx_NCX_SL" units="dimensionless" initial_value="0.89"/>
<variable name="Q10_NCX" units="dimensionless" initial_value="1.57"/>
<variable name="Q_NCX" units="dimensionless"/>
<variable name="K_mNai" units="millimolar" initial_value="12.29"/>
<variable name="K_mCao" units="millimolar" initial_value="1.3"/>
<variable name="K_mNao" units="millimolar" initial_value="87.5"/>
<variable name="K_mCai" units="millimolar" initial_value="0.00359"/>
<variable name="Ka_SL" units="dimensionless"/>
<variable name="Ka_jct" units="dimensionless"/>
<variable name="Kd_act" units="millimolar" initial_value="0.000256"/>
<variable name="ksat" units="dimensionless" initial_value="0.27"/>
<variable name="eta" units="dimensionless" initial_value="0.35"/>
<variable name="HNa" units="dimensionless" initial_value="3"/>
<variable name="V" units="millivolt" public_interface="in"/>
<variable name="R" units="joule_per_kilomole_kelvin" public_interface="in"/>
<variable name="T" units="kelvin" public_interface="in"/>
<variable name="F" units="coulomb_per_mole" public_interface="in"/>
<variable name="Nai" units="millimolar" public_interface="in"/>
<variable name="Na_SL" units="millimolar" public_interface="in"/>
<variable name="Na_jct" units="millimolar" public_interface="in"/>
<variable name="Nao" units="millimolar" public_interface="in"/>
<variable name="Cai" units="millimolar" public_interface="in"/>
<variable name="Ca_SL" units="millimolar" public_interface="in"/>
<variable name="Ca_jct" units="millimolar" public_interface="in"/>
<variable name="Cao" units="millimolar" public_interface="in"/>
<variable name="temp_jct" units="millimolar4"/>
<variable name="temp_SL" units="millimolar4"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>temp_jct</ci>
<apply>
<divide/>
<apply>
<minus/>
<apply>
<times/>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<times/>
<ci>eta</ci>
<ci>V</ci>
<ci>F</ci>
</apply>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
<apply>
<power/>
<ci>Na_jct</ci>
<ci>HNa</ci>
</apply>
<ci>Cao</ci>
</apply>
<apply>
<times/>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<times/>
<apply>
<minus/>
<ci>eta</ci>
<cn cellml:units="dimensionless">1</cn>
</apply>
<ci>V</ci>
<ci>F</ci>
</apply>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
<apply>
<power/>
<ci>Nao</ci>
<ci>HNa</ci>
</apply>
<ci>Ca_jct</ci>
</apply>
</apply>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<times/>
<ci>ksat</ci>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<times/>
<apply>
<minus/>
<ci>eta</ci>
<cn cellml:units="dimensionless">1</cn>
</apply>
<ci>V</ci>
<ci>F</ci>
</apply>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>temp_SL</ci>
<apply>
<divide/>
<apply>
<minus/>
<apply>
<times/>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<times/>
<ci>eta</ci>
<ci>V</ci>
<ci>F</ci>
</apply>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
<apply>
<power/>
<ci>Na_SL</ci>
<ci>HNa</ci>
</apply>
<ci>Cao</ci>
</apply>
<apply>
<times/>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<times/>
<apply>
<minus/>
<ci>eta</ci>
<cn cellml:units="dimensionless">1</cn>
</apply>
<ci>V</ci>
<ci>F</ci>
</apply>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
<apply>
<power/>
<ci>Nao</ci>
<ci>HNa</ci>
</apply>
<ci>Ca_SL</ci>
</apply>
</apply>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<times/>
<ci>ksat</ci>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<times/>
<apply>
<minus/>
<ci>eta</ci>
<cn cellml:units="dimensionless">1</cn>
</apply>
<ci>V</ci>
<ci>F</ci>
</apply>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>Q_NCX</ci>
<apply>
<power/>
<ci>Q10_NCX</ci>
<apply>
<divide/>
<apply>
<minus/>
<ci>T</ci>
<cn cellml:units="kelvin">310</cn>
</apply>
<cn cellml:units="kelvin">10</cn>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>Ka_SL</ci>
<apply>
<divide/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<power/>
<apply>
<divide/>
<ci>Kd_act</ci>
<ci>Ca_SL</ci>
</apply>
<cn cellml:units="dimensionless">3</cn>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>Ka_jct</ci>
<apply>
<divide/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<power/>
<apply>
<divide/>
<ci>Kd_act</ci>
<ci>Ca_jct</ci>
</apply>
<cn cellml:units="dimensionless">3</cn>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>i_NaCa_jct</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>Fx_NCX_jct</ci>
<ci>V_max</ci>
<ci>Ka_jct</ci>
<ci>Q_NCX</ci>
<ci>temp_jct</ci>
</apply>
<apply>
<plus/>
<apply>
<times/>
<ci>K_mCai</ci>
<apply>
<power/>
<ci>Nao</ci>
<ci>HNa</ci>
</apply>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<power/>
<apply>
<divide/>
<ci>Na_jct</ci>
<ci>K_mNai</ci>
</apply>
<ci>HNa</ci>
</apply>
</apply>
</apply>
<apply>
<times/>
<apply>
<power/>
<ci>K_mNao</ci>
<ci>HNa</ci>
</apply>
<ci>Ca_jct</ci>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>Ca_jct</ci>
<ci>K_mCai</ci>
</apply>
</apply>
</apply>
<apply>
<times/>
<ci>K_mCao</ci>
<apply>
<power/>
<ci>Na_jct</ci>
<ci>HNa</ci>
</apply>
</apply>
<apply>
<times/>
<apply>
<power/>
<ci>Na_jct</ci>
<ci>HNa</ci>
</apply>
<ci>Cao</ci>
</apply>
<apply>
<times/>
<apply>
<power/>
<ci>Nao</ci>
<ci>HNa</ci>
</apply>
<ci>Ca_jct</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>i_NaCa_SL</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>Fx_NCX_SL</ci>
<ci>V_max</ci>
<ci>Ka_SL</ci>
<ci>Q_NCX</ci>
<ci>temp_SL</ci>
</apply>
<apply>
<plus/>
<apply>
<times/>
<ci>K_mCai</ci>
<apply>
<power/>
<ci>Nao</ci>
<ci>HNa</ci>
</apply>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<power/>
<apply>
<divide/>
<ci>Na_SL</ci>
<ci>K_mNai</ci>
</apply>
<ci>HNa</ci>
</apply>
</apply>
</apply>
<apply>
<times/>
<apply>
<power/>
<ci>K_mNao</ci>
<ci>HNa</ci>
</apply>
<ci>Ca_SL</ci>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>Ca_SL</ci>
<ci>K_mCai</ci>
</apply>
</apply>
</apply>
<apply>
<times/>
<ci>K_mCao</ci>
<apply>
<power/>
<ci>Na_SL</ci>
<ci>HNa</ci>
</apply>
</apply>
<apply>
<times/>
<apply>
<power/>
<ci>Na_SL</ci>
<ci>HNa</ci>
</apply>
<ci>Cao</ci>
</apply>
<apply>
<times/>
<apply>
<power/>
<ci>Nao</ci>
<ci>HNa</ci>
</apply>
<ci>Ca_SL</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>i_NaCa</ci>
<apply>
<plus/>
<ci>i_NaCa_jct</ci>
<ci>i_NaCa_SL</ci>
</apply>
</apply>
</math>
</component>
<component xmlns="http://www.cellml.org/cellml/1.0#" name="ICap">
<variable name="i_Cap" units="microA_per_microF" public_interface="out"/>
<variable name="i_Cap_SL" units="microA_per_microF" public_interface="out"/>
<variable name="i_Cap_jct" units="microA_per_microF" public_interface="out"/>
<variable name="Fx_SLCaP_jct" units="dimensionless" initial_value="0.11"/>
<variable name="Fx_SLCaP_SL" units="dimensionless" initial_value="0.89"/>
<variable name="Q10_SLCaP" units="dimensionless" initial_value="2.35"/>
<variable name="Q_SLCaP" units="dimensionless"/>
<variable name="Km" units="millimolar" initial_value="0.0005"/>
<variable name="H" units="dimensionless" initial_value="1.6"/>
<variable name="Cai" units="millimolar" public_interface="in"/>
<variable name="Ca_SL" units="millimolar" public_interface="in"/>
<variable name="Ca_jct" units="millimolar" public_interface="in"/>
<variable name="T" units="kelvin" public_interface="in"/>
<variable name="F" units="coulomb_per_mole" public_interface="in"/>
<variable name="Vol_myo" units="litre" public_interface="in"/>
<variable name="Cm" units="farad" public_interface="in"/>
<variable name="V_maxAF" units="microA_per_microF" initial_value="0.0673"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>Q_SLCaP</ci>
<apply>
<power/>
<ci>Q10_SLCaP</ci>
<apply>
<divide/>
<apply>
<minus/>
<ci>T</ci>
<cn cellml:units="kelvin">310</cn>
</apply>
<cn cellml:units="kelvin">10</cn>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>i_Cap_jct</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>Q_SLCaP</ci>
<ci>V_maxAF</ci>
<ci>Fx_SLCaP_jct</ci>
</apply>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<power/>
<apply>
<divide/>
<ci>Km</ci>
<ci>Ca_jct</ci>
</apply>
<ci>H</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>i_Cap_SL</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>Q_SLCaP</ci>
<ci>V_maxAF</ci>
<ci>Fx_SLCaP_SL</ci>
</apply>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<power/>
<apply>
<divide/>
<ci>Km</ci>
<ci>Ca_SL</ci>
</apply>
<ci>H</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>i_Cap</ci>
<apply>
<plus/>
<ci>i_Cap_jct</ci>
<ci>i_Cap_SL</ci>
</apply>
</apply>
</math>
</component>
<component xmlns="http://www.cellml.org/cellml/1.0#" name="ICab">
<variable name="i_Cab" units="microA_per_microF" public_interface="out"/>
<variable name="i_Cab_jct" units="microA_per_microF" public_interface="out"/>
<variable name="i_Cab_SL" units="microA_per_microF" public_interface="out"/>
<variable name="G_CaBk" units="milliS_per_microF" initial_value="0.0002513"/>
<variable name="Fx_CaBk_jct" units="dimensionless" initial_value="0.11"/>
<variable name="Fx_CaBk_SL" units="dimensionless" initial_value="0.89"/>
<variable name="V" units="millivolt" public_interface="in"/>
<variable name="E_Ca_SL" units="millivolt" public_interface="in"/>
<variable name="E_Ca_jct" units="millivolt" public_interface="in"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>i_Cab_jct</ci>
<apply>
<times/>
<ci>G_CaBk</ci>
<ci>Fx_CaBk_jct</ci>
<apply>
<minus/>
<ci>V</ci>
<ci>E_Ca_jct</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>i_Cab_SL</ci>
<apply>
<times/>
<ci>G_CaBk</ci>
<ci>Fx_CaBk_SL</ci>
<apply>
<minus/>
<ci>V</ci>
<ci>E_Ca_SL</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>i_Cab</ci>
<apply>
<plus/>
<ci>i_Cab_SL</ci>
<ci>i_Cab_jct</ci>
</apply>
</apply>
</math>
</component>
<component xmlns="http://www.cellml.org/cellml/1.0#" name="Jrel_SR">
<variable cmeta:id="Jrel_SR_j_rel_SR" name="j_rel_SR" units="millimolar_per_millisecond" public_interface="out"/>
<variable name="Max_SR" units="dimensionless" initial_value="15"/>
<variable name="Min_SR" units="dimensionless" initial_value="1"/>
<variable name="EC50_SR" units="millimolar" initial_value="0.45"/>
<variable name="R" units="dimensionless" initial_value="8.884332e-1" public_interface="out"/>
<variable name="I" units="dimensionless" initial_value="1.024274e-7" public_interface="out"/>
<variable name="RI" units="dimensionless"/>
<variable name="O" units="dimensionless" initial_value="8.156628e-7" public_interface="out"/>
<variable name="ks" units="per_millisecond" initial_value="25"/>
<variable name="koCa" units="per_millimolar2_per_millisecond" initial_value="10"/>
<variable name="kom" units="per_millisecond" initial_value="0.06"/>
<variable name="kiCa" units="per_millimolar_per_millisecond" initial_value="0.5"/>
<variable name="kim" units="per_millisecond" initial_value="0.005"/>
<variable name="HSR" units="dimensionless" initial_value="2.5"/>
<variable name="Ca_jct" units="millimolar" public_interface="in"/>
<variable name="Ca_SR" units="millimolar" public_interface="in"/>
<variable name="time" units="millisecond" public_interface="in"/>
<variable name="kCaSR" units="dimensionless"/>
<variable name="koSRCa" units="per_millimolar2_per_millisecond"/>
<variable name="kiSRCa" units="per_millimolar_per_millisecond"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>kCaSR</ci>
<apply>
<minus/>
<ci>Max_SR</ci>
<apply>
<divide/>
<apply>
<minus/>
<ci>Max_SR</ci>
<ci>Min_SR</ci>
</apply>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<power/>
<apply>
<divide/>
<ci>EC50_SR</ci>
<ci>Ca_SR</ci>
</apply>
<ci>HSR</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>koSRCa</ci>
<apply>
<divide/>
<ci>koCa</ci>
<ci>kCaSR</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>kiSRCa</ci>
<apply>
<times/>
<ci>kiCa</ci>
<ci>kCaSR</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>RI</ci>
<apply>
<minus/>
<apply>
<minus/>
<apply>
<minus/>
<cn cellml:units="dimensionless">1</cn>
<ci>R</ci>
</apply>
<ci>O</ci>
</apply>
<ci>I</ci>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>R</ci>
</apply>
<apply>
<minus/>
<apply>
<minus/>
<apply>
<times/>
<ci>kim</ci>
<ci>RI</ci>
</apply>
<apply>
<times/>
<ci>kiSRCa</ci>
<ci>Ca_jct</ci>
<ci>R</ci>
</apply>
</apply>
<apply>
<minus/>
<apply>
<times/>
<ci>koSRCa</ci>
<apply>
<power/>
<ci>Ca_jct</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
<ci>R</ci>
</apply>
<apply>
<times/>
<ci>kom</ci>
<ci>O</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>O</ci>
</apply>
<apply>
<minus/>
<apply>
<minus/>
<apply>
<times/>
<ci>koSRCa</ci>
<apply>
<power/>
<ci>Ca_jct</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
<ci>R</ci>
</apply>
<apply>
<times/>
<ci>kom</ci>
<ci>O</ci>
</apply>
</apply>
<apply>
<minus/>
<apply>
<times/>
<ci>kiSRCa</ci>
<ci>Ca_jct</ci>
<ci>O</ci>
</apply>
<apply>
<times/>
<ci>kim</ci>
<ci>I</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>I</ci>
</apply>
<apply>
<minus/>
<apply>
<minus/>
<apply>
<times/>
<ci>kiSRCa</ci>
<ci>Ca_jct</ci>
<ci>O</ci>
</apply>
<apply>
<times/>
<ci>kim</ci>
<ci>I</ci>
</apply>
</apply>
<apply>
<minus/>
<apply>
<times/>
<ci>kom</ci>
<ci>I</ci>
</apply>
<apply>
<times/>
<ci>koSRCa</ci>
<apply>
<power/>
<ci>Ca_jct</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
<ci>RI</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>j_rel_SR</ci>
<apply>
<times/>
<ci>ks</ci>
<ci>O</ci>
<apply>
<minus/>
<ci>Ca_SR</ci>
<ci>Ca_jct</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component xmlns="http://www.cellml.org/cellml/1.0#" name="Jleak_SR">
<variable cmeta:id="Jleak_SR_j_leak_SR" name="j_leak_SR" units="millimolar_per_millisecond" public_interface="out"/>
<variable name="KSRleak" units="per_millisecond" initial_value="5.348e-6"/>
<variable name="Ca_jct" units="millimolar" public_interface="in"/>
<variable name="Ca_SR" units="millimolar" public_interface="in"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>j_leak_SR</ci>
<apply>
<times/>
<ci>KSRleak</ci>
<apply>
<minus/>
<ci>Ca_SR</ci>
<ci>Ca_jct</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component xmlns="http://www.cellml.org/cellml/1.0#" name="Jpump_SR">
<variable cmeta:id="Jpump_SR_j_pump_SR" name="j_pump_SR" units="millimolar_per_millisecond" public_interface="out"/>
<variable name="V_max" units="millimolar_per_millisecond" initial_value="5.3114e-3"/>
<variable name="Q10_SRCaP" units="dimensionless" initial_value="2.6"/>
<variable name="Q_SRCaP" units="dimensionless"/>
<variable name="Kmf" units="millimolar" initial_value="0.000246"/>
<variable name="Kmr" units="millimolar" initial_value="1.7"/>
<variable name="H" units="dimensionless" initial_value="1.787"/>
<variable name="Cai" units="millimolar" public_interface="in"/>
<variable name="Ca_SR" units="millimolar" public_interface="in"/>
<variable name="T" units="kelvin" public_interface="in"/>
<variable name="Vol_myo" units="litre" public_interface="in" private_interface="out"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>Q_SRCaP</ci>
<apply>
<power/>
<ci>Q10_SRCaP</ci>
<apply>
<divide/>
<apply>
<minus/>
<ci>T</ci>
<cn cellml:units="kelvin">310</cn>
</apply>
<cn cellml:units="kelvin">10</cn>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>j_pump_SR</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>Q_SRCaP</ci>
<ci>V_max</ci>
<apply>
<minus/>
<apply>
<power/>
<apply>
<divide/>
<ci>Cai</ci>
<ci>Kmf</ci>
</apply>
<ci>H</ci>
</apply>
<apply>
<power/>
<apply>
<divide/>
<ci>Ca_SR</ci>
<ci>Kmr</ci>
</apply>
<ci>H</ci>
</apply>
</apply>
</apply>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<power/>
<apply>
<divide/>
<ci>Cai</ci>
<ci>Kmf</ci>
</apply>
<ci>H</ci>
</apply>
<apply>
<power/>
<apply>
<divide/>
<ci>Ca_SR</ci>
<ci>Kmr</ci>
</apply>
<ci>H</ci>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component xmlns="http://www.cellml.org/cellml/1.0#" name="ion_diffusion">
<variable name="J_Na_jct_SL" units="millimole_per_millisecond" public_interface="out"/>
<variable name="J_Na_SL_myo" units="millimole_per_millisecond" public_interface="out"/>
<variable name="J_Ca_jct_SL" units="millimole_per_millisecond" public_interface="out"/>
<variable name="J_Ca_SL_myo" units="millimole_per_millisecond" public_interface="out"/>
<variable name="Na_SL" units="millimolar" public_interface="in"/>
<variable name="Na_jct" units="millimolar" public_interface="in"/>
<variable name="Nai" units="millimolar" public_interface="in"/>
<variable name="Ca_SL" units="millimolar" public_interface="in"/>
<variable name="Cai" units="millimolar" public_interface="in"/>
<variable name="Ca_jct" units="millimolar" public_interface="in"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>J_Na_jct_SL</ci>
<apply>
<times/>
<apply>
<minus/>
<ci>Na_jct</ci>
<ci>Na_SL</ci>
</apply>
<cn type="e-notation" cellml:units="litre_per_millisecond">1.8313 <sep/>
-14</cn>
</apply>
</apply>
<apply>
<eq/>
<ci>J_Na_SL_myo</ci>
<apply>
<times/>
<apply>
<minus/>
<ci>Na_SL</ci>
<ci>Nai</ci>
</apply>
<cn type="e-notation" cellml:units="litre_per_millisecond">1.6386 <sep/>
-12</cn>
</apply>
</apply>
<apply>
<eq/>
<ci>J_Ca_jct_SL</ci>
<apply>
<times/>
<apply>
<minus/>
<ci>Ca_jct</ci>
<ci>Ca_SL</ci>
</apply>
<cn type="e-notation" cellml:units="litre_per_millisecond">8.2413 <sep/>
-13</cn>
</apply>
</apply>
<apply>
<eq/>
<ci>J_Ca_SL_myo</ci>
<apply>
<times/>
<apply>
<minus/>
<ci>Ca_SL</ci>
<ci>Cai</ci>
</apply>
<cn type="e-notation" cellml:units="litre_per_millisecond">3.7243 <sep/>
-12</cn>
</apply>
</apply>
</math>
</component>
<component xmlns="http://www.cellml.org/cellml/1.0#" name="Na_buffer">
<variable name="Na_SL" units="millimolar" initial_value="8.80733" public_interface="out"/>
<variable name="Na_jct" units="millimolar" initial_value="8.80329" public_interface="out"/>
<variable name="Na_SL_buf" units="millimolar" initial_value="7.720854e-1" public_interface="out"/>
<variable name="Na_jct_buf" units="millimolar" initial_value="3.539892" public_interface="out"/>
<variable name="Nai" units="millimolar" initial_value="8.80853" public_interface="out"/>
<variable name="Bmax_SL" units="millimolar" initial_value="1.65"/>
<variable name="Bmax_jct" units="millimolar" initial_value="7.561"/>
<variable name="kon" units="per_millimolar_per_millisecond" initial_value="0.0001"/>
<variable name="koff" units="per_millisecond" initial_value="1e-3"/>
<variable name="J_Na_jct_SL" units="millimole_per_millisecond" public_interface="in"/>
<variable name="J_Na_SL_myo" units="millimole_per_millisecond" public_interface="in"/>
<variable name="i_Na_jct" units="microA_per_microF" public_interface="in"/>
<variable name="i_NaCa_jct" units="microA_per_microF" public_interface="in"/>
<variable name="i_Nab_jct" units="microA_per_microF" public_interface="in"/>
<variable name="i_NaK_jct" units="microA_per_microF" public_interface="in"/>
<variable name="i_CaL_Na_jct" units="microA_per_microF" public_interface="in"/>
<variable name="i_Na_SL" units="microA_per_microF" public_interface="in"/>
<variable name="i_NaCa_SL" units="microA_per_microF" public_interface="in"/>
<variable name="i_Nab_SL" units="microA_per_microF" public_interface="in"/>
<variable name="i_NaK_SL" units="microA_per_microF" public_interface="in"/>
<variable name="i_CaL_Na_SL" units="microA_per_microF" public_interface="in"/>
<variable name="Vol_SR" units="litre" public_interface="in"/>
<variable name="Vol_SL" units="litre" public_interface="in"/>
<variable name="Vol_jct" units="litre" public_interface="in"/>
<variable name="Vol_myo" units="litre" public_interface="in"/>
<variable name="F" units="coulomb_per_mole" public_interface="in"/>
<variable name="Cm" units="farad" public_interface="in"/>
<variable name="time" units="millisecond" public_interface="in"/>
<variable name="dNa_jct_buf" units="millimolar_per_millisecond"/>
<variable name="dNa_SL_buf" units="millimolar_per_millisecond"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>dNa_jct_buf</ci>
<apply>
<minus/>
<apply>
<times/>
<ci>kon</ci>
<ci>Na_jct</ci>
<apply>
<minus/>
<ci>Bmax_jct</ci>
<ci>Na_jct_buf</ci>
</apply>
</apply>
<apply>
<times/>
<ci>koff</ci>
<ci>Na_jct_buf</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>dNa_SL_buf</ci>
<apply>
<minus/>
<apply>
<times/>
<ci>kon</ci>
<ci>Na_SL</ci>
<apply>
<minus/>
<ci>Bmax_SL</ci>
<ci>Na_SL_buf</ci>
</apply>
</apply>
<apply>
<times/>
<ci>koff</ci>
<ci>Na_SL_buf</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>Na_jct_buf</ci>
</apply>
<ci>dNa_jct_buf</ci>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>Na_SL_buf</ci>
</apply>
<ci>dNa_SL_buf</ci>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>Na_jct</ci>
</apply>
<apply>
<minus/>
<apply>
<minus/>
<apply>
<divide/>
<apply>
<times/>
<apply>
<minus/>
<ci>Cm</ci>
</apply>
<apply>
<plus/>
<ci>i_Na_jct</ci>
<apply>
<times/>
<cn cellml:units="dimensionless">3</cn>
<ci>i_NaCa_jct</ci>
</apply>
<ci>i_Nab_jct</ci>
<apply>
<times/>
<cn cellml:units="dimensionless">3</cn>
<ci>i_NaK_jct</ci>
</apply>
<ci>i_CaL_Na_jct</ci>
</apply>
</apply>
<apply>
<times/>
<ci>Vol_jct</ci>
<ci>F</ci>
</apply>
</apply>
<apply>
<divide/>
<ci>J_Na_jct_SL</ci>
<ci>Vol_jct</ci>
</apply>
</apply>
<ci>dNa_jct_buf</ci>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>Na_SL</ci>
</apply>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<divide/>
<apply>
<times/>
<apply>
<minus/>
<ci>Cm</ci>
</apply>
<apply>
<plus/>
<ci>i_Na_SL</ci>
<apply>
<times/>
<cn cellml:units="dimensionless">3</cn>
<ci>i_NaCa_SL</ci>
</apply>
<ci>i_Nab_SL</ci>
<apply>
<times/>
<cn cellml:units="dimensionless">3</cn>
<ci>i_NaK_SL</ci>
</apply>
<ci>i_CaL_Na_SL</ci>
</apply>
</apply>
<apply>
<times/>
<ci>Vol_SL</ci>
<ci>F</ci>
</apply>
</apply>
<apply>
<divide/>
<apply>
<minus/>
<ci>J_Na_jct_SL</ci>
<ci>J_Na_SL_myo</ci>
</apply>
<ci>Vol_SL</ci>
</apply>
</apply>
<ci>dNa_SL_buf</ci>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>Nai</ci>
</apply>
<apply>
<divide/>
<ci>J_Na_SL_myo</ci>
<ci>Vol_myo</ci>
</apply>
</apply>
</math>
</component>
<component xmlns="http://www.cellml.org/cellml/1.0#" name="Ca_buffer">
<variable name="Ca_SR" units="millimolar" initial_value="5.545201e-1" public_interface="out" private_interface="out"/>
<variable name="Ca_SL" units="millimolar" initial_value="1.031812e-4" public_interface="out" private_interface="out"/>
<variable name="Ca_jct" units="millimolar" initial_value="1.737475e-4" public_interface="out" private_interface="out"/>
<variable name="Cai" units="millimolar" initial_value="8.597401e-5" public_interface="out" private_interface="out"/>
<variable name="Mgi" units="millimolar" public_interface="in" private_interface="out"/>
<variable name="Ca_SLB_SL" units="millimolar" initial_value="1.110363e-1" public_interface="out"/>
<variable name="Ca_SLB_jct" units="millimolar" initial_value="9.566355e-3" public_interface="out"/>
<variable name="Ca_SLHigh_SL" units="millimolar" initial_value="7.297378e-2" public_interface="out"/>
<variable name="Ca_SLHigh_jct" units="millimolar" initial_value="7.347888e-3" public_interface="out"/>
<variable name="Ca_Calsequestrin" units="millimolar" initial_value="1.242988" public_interface="out"/>
<variable name="Bmax_SLB_SL" units="millimolar" initial_value="0.0374"/>
<variable name="Bmax_SLB_jct" units="millimolar" initial_value="0.0046"/>
<variable name="Bmax_SLHigh_SL" units="millimolar" initial_value="0.0134"/>
<variable name="Bmax_SLHigh_jct" units="millimolar" initial_value="0.00165"/>
<variable name="Bmax_Calsequestrin" units="millimolar" initial_value="0.14"/>
<variable name="kon_SL" units="per_millimolar_per_millisecond" initial_value="100"/>
<variable name="kon_Calsequestrin" units="per_millimolar_per_millisecond" initial_value="100"/>
<variable name="koff_SLB" units="per_millisecond" initial_value="1.3"/>
<variable name="koff_SLHigh" units="per_millisecond" initial_value="30e-3"/>
<variable name="koff_Calsequestrin" units="per_millisecond" initial_value="65"/>
<variable name="i_CaL_Ca_jct" units="microA_per_microF" public_interface="in"/>
<variable name="i_NaCa_jct" units="microA_per_microF" public_interface="in"/>
<variable name="i_Cab_jct" units="microA_per_microF" public_interface="in"/>
<variable name="i_Cap_jct" units="microA_per_microF" public_interface="in"/>
<variable name="i_CaL_Ca_SL" units="microA_per_microF" public_interface="in"/>
<variable name="i_NaCa_SL" units="microA_per_microF" public_interface="in"/>
<variable name="i_Cab_SL" units="microA_per_microF" public_interface="in"/>
<variable name="i_Cap_SL" units="microA_per_microF" public_interface="in"/>
<variable name="j_pump_SR" units="millimolar_per_millisecond" public_interface="in"/>
<variable name="j_rel_SR" units="millimolar_per_millisecond" public_interface="in"/>
<variable name="j_leak_SR" units="millimolar_per_millisecond" public_interface="in"/>
<variable name="J_Ca_jct_SL" units="millimole_per_millisecond" public_interface="in"/>
<variable name="J_Ca_SL_myo" units="millimole_per_millisecond" public_interface="in"/>
<variable name="Vol_SR" units="litre" public_interface="in"/>
<variable name="Vol_SL" units="litre" public_interface="in" private_interface="out"/>
<variable name="Vol_jct" units="litre" public_interface="in" private_interface="out"/>
<variable name="Vol_myo" units="litre" public_interface="in" private_interface="out"/>
<variable name="F" units="coulomb_per_mole" public_interface="in"/>
<variable name="Cm" units="farad" public_interface="in"/>
<variable name="time" units="millisecond" public_interface="in" private_interface="out"/>
<variable name="dCalsequestrin" units="millimolar_per_millisecond"/>
<variable name="dCa_cytosol_tot_bound" units="millimolar_per_millisecond" private_interface="in"/>
<variable name="dCa_SLB_SL" units="millimolar_per_millisecond"/>
<variable name="dCa_SLB_jct" units="millimolar_per_millisecond"/>
<variable name="dCa_SLHigh_SL" units="millimolar_per_millisecond"/>
<variable name="dCa_SLHigh_jct" units="millimolar_per_millisecond"/>
<variable name="dCa_jct_tot_bound" units="millimolar_per_millisecond"/>
<variable name="dCa_SL_tot_bound" units="millimolar_per_millisecond"/>
<variable name="i_Ca_jct_tot" units="microA_per_microF"/>
<variable name="i_Ca_SL_tot" units="microA_per_microF"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>dCalsequestrin</ci>
<apply>
<minus/>
<apply>
<times/>
<ci>kon_Calsequestrin</ci>
<ci>Ca_SR</ci>
<apply>
<minus/>
<apply>
<divide/>
<apply>
<times/>
<ci>Bmax_Calsequestrin</ci>
<ci>Vol_myo</ci>
</apply>
<ci>Vol_SR</ci>
</apply>
<ci>Ca_Calsequestrin</ci>
</apply>
</apply>
<apply>
<times/>
<ci>koff_Calsequestrin</ci>
<ci>Ca_Calsequestrin</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>Ca_Calsequestrin</ci>
</apply>
<ci>dCalsequestrin</ci>
</apply>
<apply>
<eq/>
<ci>dCa_SLB_SL</ci>
<apply>
<minus/>
<apply>
<times/>
<ci>kon_SL</ci>
<ci>Ca_SL</ci>
<apply>
<minus/>
<apply>
<divide/>
<apply>
<times/>
<ci>Bmax_SLB_SL</ci>
<ci>Vol_myo</ci>
</apply>
<ci>Vol_SL</ci>
</apply>
<ci>Ca_SLB_SL</ci>
</apply>
</apply>
<apply>
<times/>
<ci>koff_SLB</ci>
<ci>Ca_SLB_SL</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>dCa_SLB_jct</ci>
<apply>
<minus/>
<apply>
<times/>
<ci>kon_SL</ci>
<ci>Ca_jct</ci>
<apply>
<minus/>
<apply>
<divide/>
<apply>
<times/>
<ci>Bmax_SLB_jct</ci>
<cn cellml:units="dimensionless">0.1</cn>
<ci>Vol_myo</ci>
</apply>
<ci>Vol_jct</ci>
</apply>
<ci>Ca_SLB_jct</ci>
</apply>
</apply>
<apply>
<times/>
<ci>koff_SLB</ci>
<ci>Ca_SLB_jct</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>dCa_SLHigh_SL</ci>
<apply>
<minus/>
<apply>
<times/>
<ci>kon_SL</ci>
<ci>Ca_SL</ci>
<apply>
<minus/>
<apply>
<divide/>
<apply>
<times/>
<ci>Bmax_SLHigh_SL</ci>
<ci>Vol_myo</ci>
</apply>
<ci>Vol_SL</ci>
</apply>
<ci>Ca_SLHigh_SL</ci>
</apply>
</apply>
<apply>
<times/>
<ci>koff_SLHigh</ci>
<ci>Ca_SLHigh_SL</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>dCa_SLHigh_jct</ci>
<apply>
<minus/>
<apply>
<times/>
<ci>kon_SL</ci>
<ci>Ca_jct</ci>
<apply>
<minus/>
<apply>
<divide/>
<apply>
<times/>
<ci>Bmax_SLHigh_jct</ci>
<cn cellml:units="dimensionless">0.1</cn>
<ci>Vol_myo</ci>
</apply>
<ci>Vol_jct</ci>
</apply>
<ci>Ca_SLHigh_jct</ci>
</apply>
</apply>
<apply>
<times/>
<ci>koff_SLHigh</ci>
<ci>Ca_SLHigh_jct</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>Ca_SLB_SL</ci>
</apply>
<ci>dCa_SLB_SL</ci>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>Ca_SLB_jct</ci>
</apply>
<ci>dCa_SLB_jct</ci>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>Ca_SLHigh_SL</ci>
</apply>
<ci>dCa_SLHigh_SL</ci>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>Ca_SLHigh_jct</ci>
</apply>
<ci>dCa_SLHigh_jct</ci>
</apply>
<apply>
<eq/>
<ci>dCa_jct_tot_bound</ci>
<apply>
<plus/>
<ci>dCa_SLB_jct</ci>
<ci>dCa_SLHigh_jct</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>dCa_SL_tot_bound</ci>
<apply>
<plus/>
<ci>dCa_SLB_SL</ci>
<ci>dCa_SLHigh_SL</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>i_Ca_jct_tot</ci>
<apply>
<plus/>
<apply>
<minus/>
<ci>i_CaL_Ca_jct</ci>
<apply>
<times/>
<cn cellml:units="dimensionless">2</cn>
<ci>i_NaCa_jct</ci>
</apply>
</apply>
<ci>i_Cab_jct</ci>
<ci>i_Cap_jct</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>i_Ca_SL_tot</ci>
<apply>
<plus/>
<apply>
<minus/>
<ci>i_CaL_Ca_SL</ci>
<apply>
<times/>
<cn cellml:units="dimensionless">2</cn>
<ci>i_NaCa_SL</ci>
</apply>
</apply>
<ci>i_Cab_SL</ci>
<ci>i_Cap_SL</ci>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>Ca_SR</ci>
</apply>
<apply>
<minus/>
<apply>
<minus/>
<ci>j_pump_SR</ci>
<apply>
<plus/>
<apply>
<divide/>
<apply>
<times/>
<ci>j_leak_SR</ci>
<ci>Vol_myo</ci>
</apply>
<ci>Vol_SR</ci>
</apply>
<ci>j_rel_SR</ci>
</apply>
</apply>
<ci>dCalsequestrin</ci>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>Ca_jct</ci>
</apply>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<minus/>
<apply>
<divide/>
<apply>
<times/>
<apply>
<minus/>
<ci>i_Ca_jct_tot</ci>
</apply>
<ci>Cm</ci>
</apply>
<apply>
<times/>
<ci>Vol_jct</ci>
<cn cellml:units="dimensionless">2</cn>
<ci>F</ci>
</apply>
</apply>
<apply>
<divide/>
<ci>J_Ca_jct_SL</ci>
<ci>Vol_jct</ci>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>j_rel_SR</ci>
<ci>Vol_SR</ci>
</apply>
<ci>Vol_jct</ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>j_leak_SR</ci>
<ci>Vol_myo</ci>
</apply>
<ci>Vol_jct</ci>
</apply>
</apply>
<apply>
<times/>
<cn cellml:units="dimensionless">1</cn>
<ci>dCa_jct_tot_bound</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>Ca_SL</ci>
</apply>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<divide/>
<apply>
<times/>
<apply>
<minus/>
<ci>i_Ca_SL_tot</ci>
</apply>
<ci>Cm</ci>
</apply>
<apply>
<times/>
<ci>Vol_SL</ci>
<cn cellml:units="dimensionless">2</cn>
<ci>F</ci>
</apply>
</apply>
<apply>
<divide/>
<apply>
<minus/>
<ci>J_Ca_jct_SL</ci>
<ci>J_Ca_SL_myo</ci>
</apply>
<ci>Vol_SL</ci>
</apply>
</apply>
<apply>
<times/>
<cn cellml:units="dimensionless">1</cn>
<ci>dCa_SL_tot_bound</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>Cai</ci>
</apply>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<divide/>
<apply>
<times/>
<apply>
<minus/>
<ci>j_pump_SR</ci>
</apply>
<ci>Vol_SR</ci>
</apply>
<ci>Vol_myo</ci>
</apply>
<apply>
<divide/>
<ci>J_Ca_SL_myo</ci>
<ci>Vol_myo</ci>
</apply>
</apply>
<apply>
<times/>
<cn cellml:units="dimensionless">1</cn>
<ci>dCa_cytosol_tot_bound</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component xmlns="http://www.cellml.org/cellml/1.0#" name="cytosolic_Ca_buffer">
<variable name="Cai" units="millimolar" public_interface="in"/>
<variable name="Mgi" units="millimolar" public_interface="in"/>
<variable name="time" units="millisecond" public_interface="in"/>
<variable name="Ca_TroponinC" units="millimolar" initial_value="8.773191e-3" public_interface="out"/>
<variable name="Ca_TroponinC_Ca_Mg" units="millimolar" initial_value="1.078283e-1" public_interface="out"/>
<variable name="Mg_TroponinC_Ca_Mg" units="millimolar" initial_value="1.524002e-2" public_interface="out"/>
<variable name="Ca_Calmodulin" units="millimolar" initial_value="2.911916e-4" public_interface="out"/>
<variable name="Ca_Myosin" units="millimolar" initial_value="1.298754e-3" public_interface="out"/>
<variable name="Mg_Myosin" units="millimolar" initial_value="1.381982e-1" public_interface="out"/>
<variable name="Ca_SRB" units="millimolar" initial_value="2.143165e-3" public_interface="out"/>
<variable name="Bmax_TroponinC" units="millimolar" initial_value="0.07"/>
<variable name="Bmax_TroponinC_Ca_Mg_Ca" units="millimolar" initial_value="0.14"/>
<variable name="Bmax_TroponinC_Ca_Mg_Mg" units="millimolar" initial_value="0.14"/>
<variable name="Bmax_Calmodulin" units="millimolar" initial_value="0.024"/>
<variable name="Bmax_Myosin_Ca" units="millimolar" initial_value="0.14"/>
<variable name="Bmax_Myosin_Mg" units="millimolar" initial_value="0.14"/>
<variable name="Bmax_SRB" units="millimolar" initial_value="0.0171"/>
<variable name="kon_TroponinC" units="per_millimolar_per_millisecond" initial_value="32.7"/>
<variable name="kon_TroponinC_Ca_Mg_Ca" units="per_millimolar_per_millisecond" initial_value="2.37"/>
<variable name="kon_TroponinC_Ca_Mg_Mg" units="per_millimolar_per_millisecond" initial_value="3e-3"/>
<variable name="kon_Calmodulin" units="per_millimolar_per_millisecond" initial_value="34"/>
<variable name="kon_Myosin_Ca" units="per_millimolar_per_millisecond" initial_value="13.8"/>
<variable name="kon_Myosin_Mg" units="per_millimolar_per_millisecond" initial_value="15.7e-3"/>
<variable name="kon_SRB" units="per_millimolar_per_millisecond" initial_value="100"/>
<variable name="koff_TroponinC" units="per_millisecond" initial_value="19.6e-3"/>
<variable name="koff_TroponinC_Ca_Mg_Ca" units="per_millisecond" initial_value="0.032e-3"/>
<variable name="koff_TroponinC_Ca_Mg_Mg" units="per_millisecond" initial_value="3.33e-3"/>
<variable name="koff_Calmodulin" units="per_millisecond" initial_value="238e-3"/>
<variable name="koff_Myosin_Ca" units="per_millisecond" initial_value="0.46e-3"/>
<variable name="koff_Myosin_Mg" units="per_millisecond" initial_value="0.057e-3"/>
<variable name="koff_SRB" units="per_millisecond" initial_value="60e-3"/>
<variable name="dCa_TroponinC" units="millimolar_per_millisecond"/>
<variable name="dCa_TroponinC_Ca_Mg" units="millimolar_per_millisecond"/>
<variable name="dMg_TroponinC_Ca_Mg" units="millimolar_per_millisecond"/>
<variable name="dCa_Calmodulin" units="millimolar_per_millisecond"/>
<variable name="dCa_Myosin" units="millimolar_per_millisecond"/>
<variable name="dMg_Myosin" units="millimolar_per_millisecond"/>
<variable name="dCa_SRB" units="millimolar_per_millisecond"/>
<variable name="dCa_cytosol_tot_bound" units="millimolar_per_millisecond" public_interface="out"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>dCa_TroponinC</ci>
<apply>
<minus/>
<apply>
<times/>
<ci>kon_TroponinC</ci>
<ci>Cai</ci>
<apply>
<minus/>
<ci>Bmax_TroponinC</ci>
<ci>Ca_TroponinC</ci>
</apply>
</apply>
<apply>
<times/>
<ci>koff_TroponinC</ci>
<ci>Ca_TroponinC</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>dCa_TroponinC_Ca_Mg</ci>
<apply>
<minus/>
<apply>
<times/>
<ci>kon_TroponinC_Ca_Mg_Ca</ci>
<ci>Cai</ci>
<apply>
<minus/>
<ci>Bmax_TroponinC_Ca_Mg_Ca</ci>
<apply>
<plus/>
<ci>Ca_TroponinC_Ca_Mg</ci>
<ci>Mg_TroponinC_Ca_Mg</ci>
</apply>
</apply>
</apply>
<apply>
<times/>
<ci>koff_TroponinC_Ca_Mg_Ca</ci>
<ci>Ca_TroponinC_Ca_Mg</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>dMg_TroponinC_Ca_Mg</ci>
<apply>
<minus/>
<apply>
<times/>
<ci>kon_TroponinC_Ca_Mg_Mg</ci>
<ci>Mgi</ci>
<apply>
<minus/>
<ci>Bmax_TroponinC_Ca_Mg_Mg</ci>
<apply>
<plus/>
<ci>Ca_TroponinC_Ca_Mg</ci>
<ci>Mg_TroponinC_Ca_Mg</ci>
</apply>
</apply>
</apply>
<apply>
<times/>
<ci>koff_TroponinC_Ca_Mg_Mg</ci>
<ci>Mg_TroponinC_Ca_Mg</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>dCa_Calmodulin</ci>
<apply>
<minus/>
<apply>
<times/>
<ci>kon_Calmodulin</ci>
<ci>Cai</ci>
<apply>
<minus/>
<ci>Bmax_Calmodulin</ci>
<ci>Ca_Calmodulin</ci>
</apply>
</apply>
<apply>
<times/>
<ci>koff_Calmodulin</ci>
<ci>Ca_Calmodulin</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>dCa_Myosin</ci>
<apply>
<minus/>
<apply>
<times/>
<ci>kon_Myosin_Ca</ci>
<ci>Cai</ci>
<apply>
<minus/>
<ci>Bmax_Myosin_Ca</ci>
<apply>
<plus/>
<ci>Ca_Myosin</ci>
<ci>Mg_Myosin</ci>
</apply>
</apply>
</apply>
<apply>
<times/>
<ci>koff_Myosin_Ca</ci>
<ci>Ca_Myosin</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>dMg_Myosin</ci>
<apply>
<minus/>
<apply>
<times/>
<ci>kon_Myosin_Mg</ci>
<ci>Mgi</ci>
<apply>
<minus/>
<ci>Bmax_Myosin_Mg</ci>
<apply>
<plus/>
<ci>Ca_Myosin</ci>
<ci>Mg_Myosin</ci>
</apply>
</apply>
</apply>
<apply>
<times/>
<ci>koff_Myosin_Mg</ci>
<ci>Mg_Myosin</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>dCa_SRB</ci>
<apply>
<minus/>
<apply>
<times/>
<ci>kon_SRB</ci>
<ci>Cai</ci>
<apply>
<minus/>
<ci>Bmax_SRB</ci>
<ci>Ca_SRB</ci>
</apply>
</apply>
<apply>
<times/>
<ci>koff_SRB</ci>
<ci>Ca_SRB</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>dCa_cytosol_tot_bound</ci>
<apply>
<plus/>
<ci>dCa_TroponinC</ci>
<ci>dCa_TroponinC_Ca_Mg</ci>
<ci>dMg_TroponinC_Ca_Mg</ci>
<ci>dCa_Calmodulin</ci>
<ci>dCa_Myosin</ci>
<ci>dMg_Myosin</ci>
<ci>dCa_SRB</ci>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>Ca_TroponinC</ci>
</apply>
<ci>dCa_TroponinC</ci>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>Ca_TroponinC_Ca_Mg</ci>
</apply>
<ci>dCa_TroponinC_Ca_Mg</ci>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>Mg_TroponinC_Ca_Mg</ci>
</apply>
<ci>dMg_TroponinC_Ca_Mg</ci>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>Ca_Calmodulin</ci>
</apply>
<ci>dCa_Calmodulin</ci>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>Ca_Myosin</ci>
</apply>
<ci>dCa_Myosin</ci>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>Mg_Myosin</ci>
</apply>
<ci>dMg_Myosin</ci>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>Ca_SRB</ci>
</apply>
<ci>dCa_SRB</ci>
</apply>
</math>
</component>
<component xmlns="http://www.cellml.org/cellml/1.0#" name="Ions_n_reversal_potentials"/>
<component xmlns="http://www.cellml.org/cellml/1.0#" name="transmembrane_currents"/>
<component xmlns="http://www.cellml.org/cellml/1.0#" name="intracellular_currents"/>
<group xmlns="http://www.cellml.org/cellml/1.0#">
<relationship_ref relationship="containment"/>
<component_ref component="cell">
<component_ref component="transmembrane_currents">
<component_ref component="INa">
<component_ref component="INa_m_gate"/>
<component_ref component="INa_h_gate"/>
<component_ref component="INa_j_gate"/>
</component_ref>
<component_ref component="ICaL">
<component_ref component="ICaL_d_gate"/>
<component_ref component="ICaL_f_gate"/>
<component_ref component="ICaL_fCa_gate"/>
</component_ref>
<component_ref component="ICap"/>
<component_ref component="ICab"/>
<component_ref component="IKs">
<component_ref component="IKs_Xs_gate"/>
</component_ref>
<component_ref component="IKr">
<component_ref component="IKr_Xr_gate"/>
<component_ref component="IKr_Rr_gate"/>
</component_ref>
<component_ref component="Itof">
<component_ref component="Itof_X_gate"/>
<component_ref component="Itof_Y_gate"/>
</component_ref>
<component_ref component="Itos">
<component_ref component="Itos_X_gate"/>
<component_ref component="Itos_Y_gate"/>
<component_ref component="Itos_R_gate"/>
</component_ref>
<component_ref component="IK1">
<component_ref component="IK1_K1_gate"/>
</component_ref>
<component_ref component="ICl_Ca"/>
<component_ref component="IClb"/>
<component_ref component="INaCa"/>
<component_ref component="INab"/>
<component_ref component="INaK"/>
</component_ref>
<component_ref component="Ions_n_reversal_potentials">
<component_ref component="Ca_buffer">
<component_ref component="cytosolic_Ca_buffer"/>
</component_ref>
<component_ref component="reversal_potentials"/>
<component_ref component="ion_diffusion"/>
<component_ref component="Na_buffer"/>
</component_ref>
<component_ref component="intracellular_currents">
<component_ref component="Jpump_SR"/>
<component_ref component="Jrel_SR"/>
<component_ref component="Jleak_SR"/>
</component_ref>
</component_ref>
</group>
<group xmlns="http://www.cellml.org/cellml/1.0#">
<relationship_ref relationship="encapsulation"/>
<component_ref component="INa">
<component_ref component="INa_m_gate"/>
<component_ref component="INa_h_gate"/>
<component_ref component="INa_j_gate"/>
</component_ref>
<component_ref component="ICaL">
<component_ref component="ICaL_d_gate"/>
<component_ref component="ICaL_f_gate"/>
<component_ref component="ICaL_fCa_gate"/>
</component_ref>
<component_ref component="IKs">
<component_ref component="IKs_Xs_gate"/>
</component_ref>
<component_ref component="IKr">
<component_ref component="IKr_Xr_gate"/>
<component_ref component="IKr_Rr_gate"/>
</component_ref>
<component_ref component="Itof">
<component_ref component="Itof_X_gate"/>
<component_ref component="Itof_Y_gate"/>
</component_ref>
<component_ref component="Itos">
<component_ref component="Itos_X_gate"/>
<component_ref component="Itos_Y_gate"/>
<component_ref component="Itos_R_gate"/>
</component_ref>
<component_ref component="IK1">
<component_ref component="IK1_K1_gate"/>
</component_ref>
<component_ref component="Ca_buffer">
<component_ref component="cytosolic_Ca_buffer"/>
</component_ref>
</group>
<connection xmlns="http://www.cellml.org/cellml/1.0#">
<map_components component_1="cell" component_2="environment"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection xmlns="http://www.cellml.org/cellml/1.0#">
<map_components component_1="Na_buffer" component_2="environment"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection xmlns="http://www.cellml.org/cellml/1.0#">
<map_components component_1="INa" component_2="environment"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection xmlns="http://www.cellml.org/cellml/1.0#">
<map_components component_1="Itos" component_2="environment"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection xmlns="http://www.cellml.org/cellml/1.0#">
<map_components component_1="Itof" component_2="environment"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection xmlns="http://www.cellml.org/cellml/1.0#">
<map_components component_1="IKs" component_2="environment"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection xmlns="http://www.cellml.org/cellml/1.0#">
<map_components component_1="IKr" component_2="environment"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection xmlns="http://www.cellml.org/cellml/1.0#">
<map_components component_1="Jrel_SR" component_2="environment"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection xmlns="http://www.cellml.org/cellml/1.0#">
<map_components component_1="Ca_buffer" component_2="environment"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection xmlns="http://www.cellml.org/cellml/1.0#">
<map_components component_1="ICaL" component_2="environment"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection xmlns="http://www.cellml.org/cellml/1.0#">
<map_components component_1="cell" component_2="INa"/>
<map_variables variable_1="V" variable_2="V"/>
<map_variables variable_1="i_Na" variable_2="i_Na"/>
</connection>
<connection xmlns="http://www.cellml.org/cellml/1.0#">
<map_components component_1="cell" component_2="ICaL"/>
<map_variables variable_1="V" variable_2="V"/>
<map_variables variable_1="i_CaL" variable_2="i_CaL"/>
</connection>
<connection xmlns="http://www.cellml.org/cellml/1.0#">
<map_components component_1="cell" component_2="IKp"/>
<map_variables variable_1="V" variable_2="V"/>
<map_variables variable_1="i_Kp" variable_2="i_Kp"/>
</connection>
<connection xmlns="http://www.cellml.org/cellml/1.0#">
<map_components component_1="cell" component_2="Itos"/>
<map_variables variable_1="V" variable_2="V"/>
<map_variables variable_1="i_tos" variable_2="i_tos"/>
</connection>
<connection xmlns="http://www.cellml.org/cellml/1.0#">
<map_components component_1="cell" component_2="Itof"/>
<map_variables variable_1="V" variable_2="V"/>
<map_variables variable_1="i_tof" variable_2="i_tof"/>
</connection>
<connection xmlns="http://www.cellml.org/cellml/1.0#">
<map_components component_1="cell" component_2="IKs"/>
<map_variables variable_1="V" variable_2="V"/>
<map_variables variable_1="i_Ks" variable_2="i_Ks"/>
</connection>
<connection xmlns="http://www.cellml.org/cellml/1.0#">
<map_components component_1="cell" component_2="IKr"/>
<map_variables variable_1="V" variable_2="V"/>
<map_variables variable_1="i_Kr" variable_2="i_Kr"/>
</connection>
<connection xmlns="http://www.cellml.org/cellml/1.0#">
<map_components component_1="cell" component_2="IK1"/>
<map_variables variable_1="V" variable_2="V"/>
<map_variables variable_1="i_K1" variable_2="i_K1"/>
</connection>
<connection xmlns="http://www.cellml.org/cellml/1.0#">
<map_components component_1="cell" component_2="INaCa"/>
<map_variables variable_1="V" variable_2="V"/>
<map_variables variable_1="i_NaCa" variable_2="i_NaCa"/>
</connection>
<connection xmlns="http://www.cellml.org/cellml/1.0#">
<map_components component_1="cell" component_2="INaK"/>
<map_variables variable_1="V" variable_2="V"/>
<map_variables variable_1="i_NaK" variable_2="i_NaK"/>
</connection>
<connection xmlns="http://www.cellml.org/cellml/1.0#">
<map_components component_1="cell" component_2="INab"/>
<map_variables variable_1="V" variable_2="V"/>
<map_variables variable_1="i_Nab" variable_2="i_Nab"/>
</connection>
<connection xmlns="http://www.cellml.org/cellml/1.0#">
<map_components component_1="cell" component_2="ICab"/>
<map_variables variable_1="V" variable_2="V"/>
<map_variables variable_1="i_Cab" variable_2="i_Cab"/>
</connection>
<connection xmlns="http://www.cellml.org/cellml/1.0#">
<map_components component_1="cell" component_2="ICl_Ca"/>
<map_variables variable_1="V" variable_2="V"/>
<map_variables variable_1="i_Cl_Ca" variable_2="i_Cl_Ca"/>
</connection>
<connection xmlns="http://www.cellml.org/cellml/1.0#">
<map_components component_1="cell" component_2="IClb"/>
<map_variables variable_1="V" variable_2="V"/>
<map_variables variable_1="i_Clb" variable_2="i_Clb"/>
</connection>
<connection xmlns="http://www.cellml.org/cellml/1.0#">
<map_components component_1="cell" component_2="ICap"/>
<map_variables variable_1="i_Cap" variable_2="i_Cap"/>
</connection>
<connection xmlns="http://www.cellml.org/cellml/1.0#">
<map_components component_1="reversal_potentials" component_2="INa"/>
<map_variables variable_1="E_Na_jct" variable_2="E_Na_jct"/>
<map_variables variable_1="E_Na_SL" variable_2="E_Na_SL"/>
</connection>
<connection xmlns="http://www.cellml.org/cellml/1.0#">
<map_components component_1="reversal_potentials" component_2="IKp"/>
<map_variables variable_1="E_K" variable_2="E_K"/>
</connection>
<connection xmlns="http://www.cellml.org/cellml/1.0#">
<map_components component_1="reversal_potentials" component_2="Itos"/>
<map_variables variable_1="E_K" variable_2="E_K"/>
</connection>
<connection xmlns="http://www.cellml.org/cellml/1.0#">
<map_components component_1="reversal_potentials" component_2="Itof"/>
<map_variables variable_1="E_K" variable_2="E_K"/>
</connection>
<connection xmlns="http://www.cellml.org/cellml/1.0#">
<map_components component_1="reversal_potentials" component_2="IKr"/>
<map_variables variable_1="E_K" variable_2="E_K"/>
</connection>
<connection xmlns="http://www.cellml.org/cellml/1.0#">
<map_components component_1="reversal_potentials" component_2="IK1"/>
<map_variables variable_1="E_K" variable_2="E_K"/>
</connection>
<connection xmlns="http://www.cellml.org/cellml/1.0#">
<map_components component_1="reversal_potentials" component_2="INab"/>
<map_variables variable_1="E_Na_jct" variable_2="E_Na_jct"/>
<map_variables variable_1="E_Na_SL" variable_2="E_Na_SL"/>
</connection>
<connection xmlns="http://www.cellml.org/cellml/1.0#">
<map_components component_1="reversal_potentials" component_2="ICab"/>
<map_variables variable_1="E_Ca_SL" variable_2="E_Ca_SL"/>
<map_variables variable_1="E_Ca_jct" variable_2="E_Ca_jct"/>
</connection>
<connection xmlns="http://www.cellml.org/cellml/1.0#">
<map_components component_1="reversal_potentials" component_2="ICl_Ca"/>
<map_variables variable_1="E_Cl" variable_2="E_Cl"/>
</connection>
<connection xmlns="http://www.cellml.org/cellml/1.0#">
<map_components component_1="reversal_potentials" component_2="IClb"/>
<map_variables variable_1="E_Cl" variable_2="E_Cl"/>
</connection>
<connection xmlns="http://www.cellml.org/cellml/1.0#">
<map_components component_1="reversal_potentials" component_2="Na_buffer"/>
<map_variables variable_1="Nai" variable_2="Nai"/>
<map_variables variable_1="Na_jct" variable_2="Na_jct"/>
<map_variables variable_1="Na_SL" variable_2="Na_SL"/>
</connection>
<connection xmlns="http://www.cellml.org/cellml/1.0#">
<map_components component_1="reversal_potentials" component_2="Ca_buffer"/>
<map_variables variable_1="Cai" variable_2="Cai"/>
<map_variables variable_1="Ca_jct" variable_2="Ca_jct"/>
<map_variables variable_1="Ca_SL" variable_2="Ca_SL"/>
</connection>
<connection xmlns="http://www.cellml.org/cellml/1.0#">
<map_components component_1="reversal_potentials" component_2="model_parameters"/>
<map_variables variable_1="Ki" variable_2="Ki"/>
<map_variables variable_1="Cli" variable_2="Cli"/>
<map_variables variable_1="Clo" variable_2="Clo"/>
<map_variables variable_1="Nao" variable_2="Nao"/>
<map_variables variable_1="Cao" variable_2="Cao"/>
<map_variables variable_1="Ko" variable_2="Ko"/>
<map_variables variable_1="R" variable_2="R"/>
<map_variables variable_1="T" variable_2="T"/>
<map_variables variable_1="F" variable_2="F"/>
</connection>
<connection xmlns="http://www.cellml.org/cellml/1.0#">
<map_components component_1="model_parameters" component_2="Ca_buffer"/>
<map_variables variable_1="Mgi" variable_2="Mgi"/>
<map_variables variable_1="Vol_SR" variable_2="Vol_SR"/>
<map_variables variable_1="Vol_SL" variable_2="Vol_SL"/>
<map_variables variable_1="Vol_jct" variable_2="Vol_jct"/>
<map_variables variable_1="Vol_myo" variable_2="Vol_myo"/>
<map_variables variable_1="F" variable_2="F"/>
<map_variables variable_1="Cm" variable_2="Cm"/>
</connection>
<connection xmlns="http://www.cellml.org/cellml/1.0#">
<map_components component_1="model_parameters" component_2="ICaL"/>
<map_variables variable_1="R" variable_2="R"/>
<map_variables variable_1="T" variable_2="T"/>
<map_variables variable_1="F" variable_2="F"/>
<map_variables variable_1="Cao" variable_2="Cao"/>
<map_variables variable_1="Nao" variable_2="Nao"/>
<map_variables variable_1="Ko" variable_2="Ko"/>
<map_variables variable_1="Ki" variable_2="Ki"/>
</connection>
<connection xmlns="http://www.cellml.org/cellml/1.0#">
<map_components component_1="model_parameters" component_2="INaCa"/>
<map_variables variable_1="Nao" variable_2="Nao"/>
<map_variables variable_1="R" variable_2="R"/>
<map_variables variable_1="T" variable_2="T"/>
<map_variables variable_1="F" variable_2="F"/>
<map_variables variable_1="Cao" variable_2="Cao"/>
</connection>
<connection xmlns="http://www.cellml.org/cellml/1.0#">
<map_components component_1="model_parameters" component_2="INaK"/>
<map_variables variable_1="Ko" variable_2="Ko"/>
<map_variables variable_1="Nao" variable_2="Nao"/>
<map_variables variable_1="R" variable_2="R"/>
<map_variables variable_1="T" variable_2="T"/>
<map_variables variable_1="F" variable_2="F"/>
</connection>
<connection xmlns="http://www.cellml.org/cellml/1.0#">
<map_components component_1="model_parameters" component_2="IKr"/>
<map_variables variable_1="Ko" variable_2="Ko"/>
</connection>
<connection xmlns="http://www.cellml.org/cellml/1.0#">
<map_components component_1="model_parameters" component_2="IKs"/>
<map_variables variable_1="Ko" variable_2="Ko"/>
<map_variables variable_1="Ki" variable_2="Ki"/>
<map_variables variable_1="Nao" variable_2="Nao"/>
<map_variables variable_1="R" variable_2="R"/>
<map_variables variable_1="T" variable_2="T"/>
<map_variables variable_1="F" variable_2="F"/>
</connection>
<connection xmlns="http://www.cellml.org/cellml/1.0#">
<map_components component_1="model_parameters" component_2="IK1"/>
<map_variables variable_1="Ko" variable_2="Ko"/>
</connection>
<connection xmlns="http://www.cellml.org/cellml/1.0#">
<map_components component_1="model_parameters" component_2="ICap"/>
<map_variables variable_1="T" variable_2="T"/>
<map_variables variable_1="Vol_myo" variable_2="Vol_myo"/>
<map_variables variable_1="F" variable_2="F"/>
<map_variables variable_1="Cm" variable_2="Cm"/>
</connection>
<connection xmlns="http://www.cellml.org/cellml/1.0#">
<map_components component_1="model_parameters" component_2="Jpump_SR"/>
<map_variables variable_1="T" variable_2="T"/>
<map_variables variable_1="Vol_myo" variable_2="Vol_myo"/>
</connection>
<connection xmlns="http://www.cellml.org/cellml/1.0#">
<map_components component_1="model_parameters" component_2="Na_buffer"/>
<map_variables variable_1="Vol_SR" variable_2="Vol_SR"/>
<map_variables variable_1="Vol_SL" variable_2="Vol_SL"/>
<map_variables variable_1="Vol_jct" variable_2="Vol_jct"/>
<map_variables variable_1="Vol_myo" variable_2="Vol_myo"/>
<map_variables variable_1="F" variable_2="F"/>
<map_variables variable_1="Cm" variable_2="Cm"/>
</connection>
<connection xmlns="http://www.cellml.org/cellml/1.0#">
<map_components component_1="INa" component_2="INa_m_gate"/>
<map_variables variable_1="m" variable_2="m"/>
<map_variables variable_1="time" variable_2="time"/>
<map_variables variable_1="V" variable_2="V"/>
</connection>
<connection xmlns="http://www.cellml.org/cellml/1.0#">
<map_components component_1="INa" component_2="INa_h_gate"/>
<map_variables variable_1="h" variable_2="h"/>
<map_variables variable_1="time" variable_2="time"/>
<map_variables variable_1="V" variable_2="V"/>
</connection>
<connection xmlns="http://www.cellml.org/cellml/1.0#">
<map_components component_1="INa" component_2="INa_j_gate"/>
<map_variables variable_1="j" variable_2="j"/>
<map_variables variable_1="time" variable_2="time"/>
<map_variables variable_1="V" variable_2="V"/>
</connection>
<connection xmlns="http://www.cellml.org/cellml/1.0#">
<map_components component_1="ICaL" component_2="ICaL_d_gate"/>
<map_variables variable_1="d" variable_2="d"/>
<map_variables variable_1="time" variable_2="time"/>
<map_variables variable_1="V" variable_2="V"/>
</connection>
<connection xmlns="http://www.cellml.org/cellml/1.0#">
<map_components component_1="ICaL" component_2="ICaL_f_gate"/>
<map_variables variable_1="f" variable_2="f"/>
<map_variables variable_1="time" variable_2="time"/>
<map_variables variable_1="V" variable_2="V"/>
</connection>
<connection xmlns="http://www.cellml.org/cellml/1.0#">
<map_components component_1="ICaL" component_2="ICaL_fCa_gate"/>
<map_variables variable_1="fCa_SL" variable_2="fCa_SL"/>
<map_variables variable_1="fCa_jct" variable_2="fCa_jct"/>
<map_variables variable_1="time" variable_2="time"/>
<map_variables variable_1="Ca_SL" variable_2="Ca_SL"/>
<map_variables variable_1="Ca_jct" variable_2="Ca_jct"/>
</connection>
<connection xmlns="http://www.cellml.org/cellml/1.0#">
<map_components component_1="Itos" component_2="Itos_X_gate"/>
<map_variables variable_1="X_tos" variable_2="X_tos"/>
<map_variables variable_1="time" variable_2="time"/>
<map_variables variable_1="V" variable_2="V"/>
</connection>
<connection xmlns="http://www.cellml.org/cellml/1.0#">
<map_components component_1="Itos" component_2="Itos_Y_gate"/>
<map_variables variable_1="Y_tos" variable_2="Y_tos"/>
<map_variables variable_1="time" variable_2="time"/>
<map_variables variable_1="V" variable_2="V"/>
</connection>
<connection xmlns="http://www.cellml.org/cellml/1.0#">
<map_components component_1="Itos" component_2="Itos_R_gate"/>
<map_variables variable_1="R_tos" variable_2="R_tos"/>
<map_variables variable_1="time" variable_2="time"/>
<map_variables variable_1="V" variable_2="V"/>
</connection>
<connection xmlns="http://www.cellml.org/cellml/1.0#">
<map_components component_1="Itof" component_2="Itof_X_gate"/>
<map_variables variable_1="X_tof" variable_2="X_tof"/>
<map_variables variable_1="time" variable_2="time"/>
<map_variables variable_1="V" variable_2="V"/>
</connection>
<connection xmlns="http://www.cellml.org/cellml/1.0#">
<map_components component_1="Itof" component_2="Itof_Y_gate"/>
<map_variables variable_1="Y_tof" variable_2="Y_tof"/>
<map_variables variable_1="time" variable_2="time"/>
<map_variables variable_1="V" variable_2="V"/>
</connection>
<connection xmlns="http://www.cellml.org/cellml/1.0#">
<map_components component_1="IKs" component_2="IKs_Xs_gate"/>
<map_variables variable_1="Xs" variable_2="Xs"/>
<map_variables variable_1="time" variable_2="time"/>
<map_variables variable_1="V" variable_2="V"/>
</connection>
<connection xmlns="http://www.cellml.org/cellml/1.0#">
<map_components component_1="IKr" component_2="IKr_Xr_gate"/>
<map_variables variable_1="Xr" variable_2="Xr"/>
<map_variables variable_1="time" variable_2="time"/>
<map_variables variable_1="V" variable_2="V"/>
</connection>
<connection xmlns="http://www.cellml.org/cellml/1.0#">
<map_components component_1="IKr" component_2="IKr_Rr_gate"/>
<map_variables variable_1="Rr" variable_2="Rr"/>
<map_variables variable_1="V" variable_2="V"/>
</connection>
<connection xmlns="http://www.cellml.org/cellml/1.0#">
<map_components component_1="IK1" component_2="IK1_K1_gate"/>
<map_variables variable_1="K1_infinity" variable_2="K1_infinity"/>
<map_variables variable_1="V" variable_2="V"/>
<map_variables variable_1="E_K" variable_2="E_K"/>
</connection>
<connection xmlns="http://www.cellml.org/cellml/1.0#">
<map_components component_1="ion_diffusion" component_2="Na_buffer"/>
<map_variables variable_1="Nai" variable_2="Nai"/>
<map_variables variable_1="Na_jct" variable_2="Na_jct"/>
<map_variables variable_1="Na_SL" variable_2="Na_SL"/>
<map_variables variable_1="J_Na_jct_SL" variable_2="J_Na_jct_SL"/>
<map_variables variable_1="J_Na_SL_myo" variable_2="J_Na_SL_myo"/>
</connection>
<connection xmlns="http://www.cellml.org/cellml/1.0#">
<map_components component_1="ion_diffusion" component_2="Ca_buffer"/>
<map_variables variable_1="Cai" variable_2="Cai"/>
<map_variables variable_1="Ca_jct" variable_2="Ca_jct"/>
<map_variables variable_1="Ca_SL" variable_2="Ca_SL"/>
<map_variables variable_1="J_Ca_jct_SL" variable_2="J_Ca_jct_SL"/>
<map_variables variable_1="J_Ca_SL_myo" variable_2="J_Ca_SL_myo"/>
</connection>
<connection xmlns="http://www.cellml.org/cellml/1.0#">
<map_components component_1="ICl_Ca" component_2="Ca_buffer"/>
<map_variables variable_1="Ca_jct" variable_2="Ca_jct"/>
<map_variables variable_1="Ca_SL" variable_2="Ca_SL"/>
</connection>
<connection xmlns="http://www.cellml.org/cellml/1.0#">
<map_components component_1="INaK" component_2="Na_buffer"/>
<map_variables variable_1="Nai" variable_2="Nai"/>
<map_variables variable_1="Na_jct" variable_2="Na_jct"/>
<map_variables variable_1="Na_SL" variable_2="Na_SL"/>
<map_variables variable_1="i_NaK_jct" variable_2="i_NaK_jct"/>
<map_variables variable_1="i_NaK_SL" variable_2="i_NaK_SL"/>
</connection>
<connection xmlns="http://www.cellml.org/cellml/1.0#">
<map_components component_1="IKs" component_2="Ca_buffer"/>
<map_variables variable_1="Ca_jct" variable_2="Ca_jct"/>
<map_variables variable_1="Ca_SL" variable_2="Ca_SL"/>
</connection>
<connection xmlns="http://www.cellml.org/cellml/1.0#">
<map_components component_1="IKs" component_2="Na_buffer"/>
<map_variables variable_1="Nai" variable_2="Nai"/>
</connection>
<connection xmlns="http://www.cellml.org/cellml/1.0#">
<map_components component_1="ICaL" component_2="Ca_buffer"/>
<map_variables variable_1="Cai" variable_2="Cai"/>
<map_variables variable_1="Ca_SL" variable_2="Ca_SL"/>
<map_variables variable_1="Ca_jct" variable_2="Ca_jct"/>
<map_variables variable_1="i_CaL_Ca_jct" variable_2="i_CaL_Ca_jct"/>
<map_variables variable_1="i_CaL_Ca_SL" variable_2="i_CaL_Ca_SL"/>
</connection>
<connection xmlns="http://www.cellml.org/cellml/1.0#">
<map_components component_1="ICaL" component_2="Na_buffer"/>
<map_variables variable_1="Na_SL" variable_2="Na_SL"/>
<map_variables variable_1="Na_jct" variable_2="Na_jct"/>
<map_variables variable_1="i_CaL_Na_jct" variable_2="i_CaL_Na_jct"/>
<map_variables variable_1="i_CaL_Na_SL" variable_2="i_CaL_Na_SL"/>
</connection>
<connection xmlns="http://www.cellml.org/cellml/1.0#">
<map_components component_1="INaCa" component_2="Ca_buffer"/>
<map_variables variable_1="Cai" variable_2="Cai"/>
<map_variables variable_1="Ca_SL" variable_2="Ca_SL"/>
<map_variables variable_1="Ca_jct" variable_2="Ca_jct"/>
<map_variables variable_1="i_NaCa_jct" variable_2="i_NaCa_jct"/>
<map_variables variable_1="i_NaCa_SL" variable_2="i_NaCa_SL"/>
</connection>
<connection xmlns="http://www.cellml.org/cellml/1.0#">
<map_components component_1="INaCa" component_2="Na_buffer"/>
<map_variables variable_1="Nai" variable_2="Nai"/>
<map_variables variable_1="Na_SL" variable_2="Na_SL"/>
<map_variables variable_1="Na_jct" variable_2="Na_jct"/>
<map_variables variable_1="i_NaCa_jct" variable_2="i_NaCa_jct"/>
<map_variables variable_1="i_NaCa_SL" variable_2="i_NaCa_SL"/>
</connection>
<connection xmlns="http://www.cellml.org/cellml/1.0#">
<map_components component_1="INa" component_2="Na_buffer"/>
<map_variables variable_1="i_Na_jct" variable_2="i_Na_jct"/>
<map_variables variable_1="i_Na_SL" variable_2="i_Na_SL"/>
</connection>
<connection xmlns="http://www.cellml.org/cellml/1.0#">
<map_components component_1="INab" component_2="Na_buffer"/>
<map_variables variable_1="i_Nab_jct" variable_2="i_Nab_jct"/>
<map_variables variable_1="i_Nab_SL" variable_2="i_Nab_SL"/>
</connection>
<connection xmlns="http://www.cellml.org/cellml/1.0#">
<map_components component_1="ICab" component_2="Ca_buffer"/>
<map_variables variable_1="i_Cab_jct" variable_2="i_Cab_jct"/>
<map_variables variable_1="i_Cab_SL" variable_2="i_Cab_SL"/>
</connection>
<connection xmlns="http://www.cellml.org/cellml/1.0#">
<map_components component_1="Jpump_SR" component_2="Ca_buffer"/>
<map_variables variable_1="Cai" variable_2="Cai"/>
<map_variables variable_1="Ca_SR" variable_2="Ca_SR"/>
<map_variables variable_1="j_pump_SR" variable_2="j_pump_SR"/>
</connection>
<connection xmlns="http://www.cellml.org/cellml/1.0#">
<map_components component_1="ICap" component_2="Ca_buffer"/>
<map_variables variable_1="Cai" variable_2="Cai"/>
<map_variables variable_1="Ca_SL" variable_2="Ca_SL"/>
<map_variables variable_1="Ca_jct" variable_2="Ca_jct"/>
<map_variables variable_1="i_Cap_jct" variable_2="i_Cap_jct"/>
<map_variables variable_1="i_Cap_SL" variable_2="i_Cap_SL"/>
</connection>
<connection xmlns="http://www.cellml.org/cellml/1.0#">
<map_components component_1="Jrel_SR" component_2="Ca_buffer"/>
<map_variables variable_1="Ca_jct" variable_2="Ca_jct"/>
<map_variables variable_1="Ca_SR" variable_2="Ca_SR"/>
<map_variables variable_1="j_rel_SR" variable_2="j_rel_SR"/>
</connection>
<connection xmlns="http://www.cellml.org/cellml/1.0#">
<map_components component_1="Jleak_SR" component_2="Ca_buffer"/>
<map_variables variable_1="Ca_jct" variable_2="Ca_jct"/>
<map_variables variable_1="Ca_SR" variable_2="Ca_SR"/>
<map_variables variable_1="j_leak_SR" variable_2="j_leak_SR"/>
</connection>
<connection xmlns="http://www.cellml.org/cellml/1.0#">
<map_components component_1="cytosolic_Ca_buffer" component_2="Ca_buffer"/>
<map_variables variable_1="Cai" variable_2="Cai"/>
<map_variables variable_1="Mgi" variable_2="Mgi"/>
<map_variables variable_1="time" variable_2="time"/>
<map_variables variable_1="dCa_cytosol_tot_bound" variable_2="dCa_cytosol_tot_bound"/>
</connection>
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
<rdf:Seq rdf:about="rdf:#d0b890da-ce01-40d6-91c5-3eb84ded05c6">
<rdf:li rdf:resource="rdf:#1e5c50bc-fc59-4d6b-8423-8a55a3da0bd7"/>
<rdf:li rdf:resource="rdf:#a5aa38b4-e51a-4473-8692-af800f6e4f3f"/>
<rdf:li rdf:resource="rdf:#3f1b2c1a-56f4-48ef-ade9-663f4ef6e114"/>
<rdf:li rdf:resource="rdf:#9044465f-4ce1-4e50-8613-defd8d17693f"/>
<rdf:li rdf:resource="rdf:#be5277bd-9f03-4873-ad40-359d5567df3c"/>
</rdf:Seq>
<rdf:Description rdf:about="rdf:#7a49a7bf-a770-4e93-b30f-58f3026cdfcc">
<dcterms:modified xmlns:dcterms="http://purl.org/dc/terms/" rdf:resource="rdf:#eea6deef-4458-44df-a35b-960f1a1efe1e"/>
<rdf:value>units checked, curated</rdf:value>
<cmeta:modifier rdf:resource="rdf:#01926b58-726b-447c-b80a-f821d69ae82f"/>
</rdf:Description>
<rdf:Description rdf:about="rdf:#$NLNY42">
<ns7:boundIntervals xmlns:ns7="http://www.cellml.org/metadata/simulation/1.0#" rdf:resource="rdf:#$OLNY42"/>
</rdf:Description>
<rdf:Description rdf:about="rdf:#a5aa38b4-e51a-4473-8692-af800f6e4f3f">
<rdf:type rdf:resource="http://www.cellml.org/bqs/1.0#Person"/>
<vCard:N xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" rdf:resource="rdf:#70bfcec5-efc6-460c-8322-e8542ea89c34"/>
</rdf:Description>
<rdf:Description rdf:about="#shannon_2004">
<ns7:simulation xmlns:ns7="http://www.cellml.org/metadata/simulation/1.0#" rdf:resource="rdf:#$NLNY42"/>
<bqs:reference xmlns:bqs="http://www.cellml.org/bqs/1.0#" rdf:resource="rdf:#5f15c0e8-7e42-4677-a3c5-c0e983fda831"/>
<bqs:reference xmlns:bqs="http://www.cellml.org/bqs/1.0#" rdf:parseType="Resource">
<dc:subject xmlns:dc="http://purl.org/dc/elements/1.1/" rdf:parseType="Resource">
<bqs:subject_type>keyword</bqs:subject_type>
<rdf:value>
<rdf:Bag>
<rdf:li>calcium dynamics</rdf:li>
<rdf:li>cardiac</rdf:li>
<rdf:li>electrophysiology</rdf:li>
</rdf:Bag>
</rdf:value>
</dc:subject>
</bqs:reference>
<cmeta:comment rdf:resource="rdf:#02650100-4bb1-4142-bfd8-0d1dd5bf2e1b"/>
</rdf:Description>
<rdf:Description rdf:about="rdf:#0f3d6ae4-e7dd-424a-881b-db8af04857c1">
<dcterms:W3CDTF xmlns:dcterms="http://purl.org/dc/terms/">2007-12-03T07:29:30+13:00</dcterms:W3CDTF>
</rdf:Description>
<rdf:Description rdf:about="rdf:#423eb95b-74d2-42d8-a183-a8ad217c671a">
<vCard:Given xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#">Penny</vCard:Given>
<vCard:Family xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#">Noble</vCard:Family>
<vCard:Other xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#"/>
</rdf:Description>
<rdf:Description rdf:about="rdf:#0e8fabc1-50f7-421e-a58b-019596a70514">
<vCard:FN xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#"/>
</rdf:Description>
<rdf:Description rdf:about="rdf:#c082a4a6-3934-4d3e-83ae-c51d4261b74d">
<vCard:Given xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#">Christopher</vCard:Given>
<vCard:Family xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#">Weber</vCard:Family>
</rdf:Description>
<rdf:Description rdf:about="rdf:#17a5cd76-7e89-4d14-b50a-513624630a57">
<dc:creator xmlns:dc="http://purl.org/dc/elements/1.1/" rdf:resource="rdf:#7978e248-b7d4-4f3f-b6a1-db028b1cf3f8"/>
<rdf:value>This CellML model was created by Martin Fink of Oxford University using COR. In collaboration with the authors of the published model this CellML model has been modified such that it contains no typographical errors and is able to run in PCEnv and COR to produce an action potential. The units in this model have also been checked and curated.</rdf:value>
</rdf:Description>
<rdf:Description rdf:about="rdf:#eea6deef-4458-44df-a35b-960f1a1efe1e">
<dcterms:W3CDTF xmlns:dcterms="http://purl.org/dc/terms/">2008-02-25T12:16:44+13:00</dcterms:W3CDTF>
</rdf:Description>
<rdf:Description rdf:about="rdf:#$PLNY42">
<ns7:endingValue xmlns:ns7="http://www.cellml.org/metadata/simulation/1.0#">10000</ns7:endingValue>
<ns7:nonstandard-pointDensity xmlns:ns7="http://www.cellml.org/metadata/simulation/1.0#">10000</ns7:nonstandard-pointDensity>
</rdf:Description>
<rdf:Description rdf:about="rdf:#0dfc6cfe-43b3-4e58-ad05-cad51673a813">
<dcterms:modified xmlns:dcterms="http://purl.org/dc/terms/" rdf:resource="rdf:#0f3d6ae4-e7dd-424a-881b-db8af04857c1"/>
<rdf:value>Fixed all warnings in COR.</rdf:value>
<cmeta:modifier rdf:resource="rdf:#6cf90e5d-30fa-4424-bcfe-4fa3dbfd5f5a"/>
</rdf:Description>
<rdf:Description rdf:about="rdf:#e7b062e7-aedc-4359-a410-e5e96adcff8a">
<dc:creator xmlns:dc="http://purl.org/dc/elements/1.1/" rdf:resource="rdf:#d0b890da-ce01-40d6-91c5-3eb84ded05c6"/>
<dc:title xmlns:dc="http://purl.org/dc/elements/1.1/">A Mathematical Treatment of Integrated Ca Dynamics within the
Ventricular Myocyte</dc:title>
<bqs:volume xmlns:bqs="http://www.cellml.org/bqs/1.0#">87</bqs:volume>
<bqs:first_page xmlns:bqs="http://www.cellml.org/bqs/1.0#">3351</bqs:first_page>
<bqs:Journal xmlns:bqs="http://www.cellml.org/bqs/1.0#" rdf:resource="rdf:#f893a45c-0052-4d9b-aa42-f0b2fa40b578"/>
<dcterms:issued xmlns:dcterms="http://purl.org/dc/terms/" rdf:resource="rdf:#2f6b98ba-0d2c-45e6-8e1a-d3e9e4c19bb8"/>
<bqs:last_page xmlns:bqs="http://www.cellml.org/bqs/1.0#">3371</bqs:last_page>
</rdf:Description>
<rdf:Description rdf:about="rdf:#db16422e-4535-4e0e-bbf3-bb53e674a382">
<dc:creator xmlns:dc="http://purl.org/dc/elements/1.1/" rdf:resource="rdf:#0e8fabc1-50f7-421e-a58b-019596a70514"/>
<rdf:value/>
</rdf:Description>
<rdf:Description rdf:about="rdf:#2483b043-5d02-4270-957f-a67257803e2a">
<rdf:type rdf:resource="http://imc.org/vCard/3.0#internet"/>
<rdf:value/>
</rdf:Description>
<rdf:Description rdf:about="rdf:#3f1b2c1a-56f4-48ef-ade9-663f4ef6e114">
<rdf:type rdf:resource="http://www.cellml.org/bqs/1.0#Person"/>
<vCard:N xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" rdf:resource="rdf:#89a8e201-e032-492c-81f4-6bccd323a15d"/>
</rdf:Description>
<rdf:Description rdf:about="rdf:#a9b68ca7-8e56-415c-a3a4-bc977ce1fa25">
<vCard:Given xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#">Thomas</vCard:Given>
<vCard:Family xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#">Shannon</vCard:Family>
<vCard:Other xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#">R</vCard:Other>
</rdf:Description>
<rdf:Description rdf:about="rdf:#1e5c50bc-fc59-4d6b-8423-8a55a3da0bd7">
<rdf:type rdf:resource="http://www.cellml.org/bqs/1.0#Person"/>
<vCard:N xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" rdf:resource="rdf:#a9b68ca7-8e56-415c-a3a4-bc977ce1fa25"/>
</rdf:Description>
<rdf:Description rdf:about="rdf:#02650100-4bb1-4142-bfd8-0d1dd5bf2e1b">
<dc:creator xmlns:dc="http://purl.org/dc/elements/1.1/" rdf:resource="rdf:#d7549732-2e74-48d8-8a12-0f2ee255403d"/>
<rdf:value>This is the CellML description of Shannon et al.'s 2004 mathematical model of integrated calcium dynamics within the ventricular myocyte.</rdf:value>
</rdf:Description>
<rdf:Description rdf:about="rdf:#89a8e201-e032-492c-81f4-6bccd323a15d">
<vCard:Given xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#">Jose</vCard:Given>
<vCard:Family xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#">Puglisi</vCard:Family>
</rdf:Description>
<rdf:Description rdf:about="rdf:#224cecea-f8b8-4e3a-bd44-8cf8ddcdeb42">
<vCard:Given xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#">Penny</vCard:Given>
<vCard:Family xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#">Noble</vCard:Family>
<vCard:Other xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#">J</vCard:Other>
</rdf:Description>
<rdf:Description rdf:about="rdf:#70bfcec5-efc6-460c-8322-e8542ea89c34">
<vCard:Given xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#">Fei</vCard:Given>
<vCard:Family xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#">Wang</vCard:Family>
</rdf:Description>
<rdf:Description rdf:about="rdf:#2f6b98ba-0d2c-45e6-8e1a-d3e9e4c19bb8">
<dcterms:W3CDTF xmlns:dcterms="http://purl.org/dc/terms/">2004-11-00 00:00</dcterms:W3CDTF>
</rdf:Description>
<rdf:Description rdf:about="rdf:#ab598e46-17eb-45f6-a269-0448ee9baa1b">
<dcterms:W3CDTF xmlns:dcterms="http://purl.org/dc/terms/">2007-12-03T00:00:00+00:00</dcterms:W3CDTF>
</rdf:Description>
<rdf:Description rdf:about="rdf:#01926b58-726b-447c-b80a-f821d69ae82f">
<vCard:N xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" rdf:resource="rdf:#224cecea-f8b8-4e3a-bd44-8cf8ddcdeb42"/>
</rdf:Description>
<rdf:Description rdf:about="rdf:#be5277bd-9f03-4873-ad40-359d5567df3c">
<rdf:type rdf:resource="http://www.cellml.org/bqs/1.0#Person"/>
<vCard:N xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" rdf:resource="rdf:#d299bf14-0eb0-4ecd-a7b1-42e6df445bbd"/>
</rdf:Description>
<rdf:Description rdf:about="rdf:#d299bf14-0eb0-4ecd-a7b1-42e6df445bbd">
<vCard:Given xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#">Donald</vCard:Given>
<vCard:Family xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#">Bers</vCard:Family>
<vCard:Other xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#">M</vCard:Other>
</rdf:Description>
<rdf:Description rdf:about="rdf:#6c4a762a-e1ce-4319-a821-6f132a11ca0f">
<vCard:Given xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#">Martin</vCard:Given>
<vCard:Family xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#">Fink</vCard:Family>
<vCard:Other xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#"/>
</rdf:Description>
<rdf:Description rdf:about="rdf:#4cb9d2bd-091c-4cec-a29c-540be71970a7">
<vCard:Orgname xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#">Oxford University</vCard:Orgname>
<vCard:Orgunit xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#"/>
</rdf:Description>
<rdf:Description rdf:about="rdf:#9044465f-4ce1-4e50-8613-defd8d17693f">
<rdf:type rdf:resource="http://www.cellml.org/bqs/1.0#Person"/>
<vCard:N xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" rdf:resource="rdf:#c082a4a6-3934-4d3e-83ae-c51d4261b74d"/>
</rdf:Description>
<rdf:Description rdf:about="rdf:#f893a45c-0052-4d9b-aa42-f0b2fa40b578">
<dc:title xmlns:dc="http://purl.org/dc/elements/1.1/">Biophysical Journal</dc:title>
</rdf:Description>
<rdf:Description rdf:about="rdf:#e4f0bf98-6800-49e3-ba89-183e1dc4944c">
<vCard:ORG xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" rdf:resource="rdf:#4cb9d2bd-091c-4cec-a29c-540be71970a7"/>
<vCard:EMAIL xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" rdf:resource="rdf:#2483b043-5d02-4270-957f-a67257803e2a"/>
<vCard:N xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" rdf:resource="rdf:#6c4a762a-e1ce-4319-a821-6f132a11ca0f"/>
</rdf:Description>
<rdf:Description rdf:about="rdf:#7978e248-b7d4-4f3f-b6a1-db028b1cf3f8">
<vCard:FN xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#">James Lawson</vCard:FN>
</rdf:Description>
<rdf:Description rdf:about="">
<dc:title>Modified version of the model which runs to recreate the published results.</dc:title>
<dc:publisher xmlns:dc="http://purl.org/dc/elements/1.1/"/>
<cmeta:comment rdf:resource="rdf:#17a5cd76-7e89-4d14-b50a-513624630a57"/>
<dcterms:created xmlns:dcterms="http://purl.org/dc/terms/" rdf:resource="rdf:#ab598e46-17eb-45f6-a269-0448ee9baa1b"/>
<dc:creator xmlns:dc="http://purl.org/dc/elements/1.1/" rdf:resource="rdf:#e4f0bf98-6800-49e3-ba89-183e1dc4944c"/>
<cmeta:modification rdf:resource="rdf:#7a49a7bf-a770-4e93-b30f-58f3026cdfcc"/>
</rdf:Description>
<rdf:Description rdf:about="rdf:#5f15c0e8-7e42-4677-a3c5-c0e983fda831">
<bqs:Pubmed_id xmlns:bqs="http://www.cellml.org/bqs/1.0#">15347581</bqs:Pubmed_id>
<bqs:JournalArticle xmlns:bqs="http://www.cellml.org/bqs/1.0#" rdf:resource="rdf:#e7b062e7-aedc-4359-a410-e5e96adcff8a"/>
</rdf:Description>
<rdf:Description rdf:about="rdf:#6cf90e5d-30fa-4424-bcfe-4fa3dbfd5f5a">
<vCard:N xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" rdf:resource="rdf:#423eb95b-74d2-42d8-a183-a8ad217c671a"/>
</rdf:Description>
<rdf:Description rdf:about="rdf:#d7549732-2e74-48d8-8a12-0f2ee255403d">
<vCard:FN xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#">Catherine Lloyd</vCard:FN>
</rdf:Description>
<rdf:Description rdf:about="rdf:#$OLNY42">
<rdf:rest rdf:resource="http://www.w3.org/1999/02/22-rdf-syntax-ns#nil"/>
<rdf:first rdf:resource="rdf:#$PLNY42"/>
</rdf:Description>
</rdf:RDF>
</model>
