Rendering of the source text

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This CellML file was generated on 23/01/2008 at 12:49:46 using:

COR (0.9.31.857)
Copyright 2002-2008 Dr Alan Garny
http://COR.physiol.ox.ac.uk/ - COR@physiol.ox.ac.uk

CellML 1.0 was used to generate this cellular model
http://www.CellML.org/
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  <title>A mathematical treatment of integrated Ca dynamics within the ventricular myocyte</title>
  <author>
    <firstname>Martin</firstname>
          <surname>Fink</surname>
    <affiliation>
      <shortaffil>Oxford University</shortaffil>
    </affiliation>
  </author>
</articleinfo>
  <section id="sec_status">
    <title>Model Status</title>
    <para>
           This model runs in PCEnv, OpenCell and COR to recreate the published results. The units are consistent throughout. The model equations and output were checked using the original matlab code, and it currently recreates the Pace1 Stimulus protocol described. 
          </para>
  </section>
  <sect1 id="sec_structure">
<title>Model Structure</title>

<para>
ABSTRACT: We have developed a detailed mathematical model for Ca2+ handling and ionic currents in the rabbit ventricular myocyte. The objective was to develop a model that: 1), accurately reflects Ca-dependent Ca release; 2), uses realistic parameters, particularly those that concern Ca transport from the cytosol; 3), comes to steady state; 4), simulates basic excitation-contraction coupling phenomena; and 5), runs on a normal desktop computer. The model includes the following novel features: 1), the addition of a subsarcolemmal compartment to the other two commonly formulated cytosolic compartments (junctional and bulk) because ion channels in the membrane sense ion concentrations that differ from bulk; 2), the use of realistic cytosolic Ca buffering parameters; 3), a reversible sarcoplasmic reticulum (SR) Ca pump; 4), a scheme for Na-Ca exchange transport that is [Na]i dependent and allosterically regulated by [Ca]i; and 5), a practical model of SR Ca release including both inactivation/adaptation and SR Ca load dependence. The data describe normal electrical activity and Ca handling characteristics of the cardiac myocyte and the SR Ca load dependence of these processes. The model includes a realistic balance of Ca removal mechanisms (e.g., SR Ca pump versus Na-Ca exchange), and the phenomena of rest decay and frequency-dependent inotropy. A particular emphasis is placed upon reproducing the nonlinear dependence of gain and fractional SR Ca release upon SR Ca load. We conclude that this model is more robust than many previously existing models and reproduces many experimental results using parameters based largely on experimental measurements in myocytes.   
</para>

<para>
The complete original paper reference is cited below:
</para>

<para>
A mathematical treatment of integrated Ca dynamics within the ventricular myocyte, Thomas R. Shannon, Fei Wang, Jose Puglisi, Christopher Weber and Donald M. Bers, 2004, <emphasis>Biophysical Journal</emphasis>, 87, 3351-3371. <ulink url="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;list_uids=15347581&amp;dopt=Abstract">PubMed ID: 15347581</ulink>
</para>


<informalfigure float="0" id="fig_cell_diagram">
<mediaobject>
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      <title>cell diagram</title>
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    <imagedata fileref="shannon_2004.png"/>
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<caption>A schematic diagram of the cell model which highlights the calcium- and sodium-dependent components of the model in particular.</caption>
</informalfigure>



</sect1>
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                              <cn cellml:units="per_millivolt">0.079</cn>
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                        <cn type="e-notation" cellml:units="per_millisecond">3.1   <sep/>
                        5</cn>
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                              <times/>
                              <cn cellml:units="per_millivolt">0.35</cn>
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                                    <cn cellml:units="millivolt">11.1</cn>
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      <variable name="V" units="millivolt" public_interface="in"/>
      <variable name="time" units="millisecond" public_interface="in"/>
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            <ci>alpha_j</ci>
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               <piece>
                  <apply>
                     <divide/>
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                        <divide/>
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                                 <times/>
                                 <apply>
                                    <minus/>
                                    <cn type="e-notation" cellml:units="per_millisecond">1.2714   <sep/>
                                    5</cn>
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                                       <times/>
                                       <cn cellml:units="per_millivolt">0.2444</cn>
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                                 <times/>
                                 <cn type="e-notation" cellml:units="per_millisecond">3.474   <sep/>
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                                    <exp/>
                                    <apply>
                                       <times/>
                                       <apply>
                                          <minus/>
                                          <cn cellml:units="per_millivolt">0.04391</cn>
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                              <cn cellml:units="per_millivolt">0.311</cn>
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                        <cn cellml:units="millivolt">40</cn>
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               <piece>
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                     <divide/>
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                        <times/>
                        <cn cellml:units="per_millisecond">0.1212</cn>
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                           <exp/>
                           <apply>
                              <times/>
                              <apply>
                                 <minus/>
                                 <cn cellml:units="per_millivolt">0.01052</cn>
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                              <ci>V</ci>
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                           <exp/>
                           <apply>
                              <times/>
                              <apply>
                                 <minus/>
                                 <cn cellml:units="per_millivolt">0.1378</cn>
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                              <apply>
                                 <plus/>
                                 <ci>V</ci>
                                 <cn cellml:units="millivolt">40.14</cn>
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                     <ci>V</ci>
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                        <minus/>
                        <cn cellml:units="millivolt">40</cn>
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                     <divide/>
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                        <times/>
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                           <exp/>
                           <apply>
                              <times/>
                              <apply>
                                 <minus/>
                                 <cn type="e-notation" cellml:units="per_millivolt">2.535   <sep/>
                                 -7</cn>
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                              <ci>V</ci>
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                        <plus/>
                        <cn cellml:units="dimensionless">1</cn>
                        <apply>
                           <exp/>
                           <apply>
                              <times/>
                              <apply>
                                 <minus/>
                                 <cn cellml:units="per_millivolt">0.1</cn>
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                              <apply>
                                 <plus/>
                                 <ci>V</ci>
                                 <cn cellml:units="millivolt">32</cn>
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                           </apply>
                        </apply>
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         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
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               <ci>j</ci>
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            <apply>
               <minus/>
               <apply>
                  <times/>
                  <ci>alpha_j</ci>
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                     <minus/>
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                     <ci>j</ci>
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                  <times/>
                  <ci>beta_j</ci>
                  <ci>j</ci>
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            </apply>
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      </math>
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      <variable name="V" units="millivolt" public_interface="in"/>
      <variable name="time" units="millisecond" public_interface="in"/>
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            <eq/>
            <ci>alpha_m</ci>
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               <divide/>
               <apply>
                  <divide/>
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                     <times/>
                     <cn cellml:units="per_millisecond">0.32</cn>
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                        <plus/>
                        <ci>V</ci>
                        <cn cellml:units="millivolt">47.13</cn>
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                  <cn cellml:units="millivolt">1</cn>
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               <apply>
                  <minus/>
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                  <apply>
                     <exp/>
                     <apply>
                        <times/>
                        <apply>
                           <minus/>
                           <cn cellml:units="per_millivolt">0.1</cn>
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                           <plus/>
                           <ci>V</ci>
                           <cn cellml:units="millivolt">47.13</cn>
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            <eq/>
            <ci>beta_m</ci>
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               <times/>
               <cn cellml:units="per_millisecond">0.08</cn>
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                  <exp/>
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                     <divide/>
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                        <minus/>
                        <ci>V</ci>
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                  </apply>
               </apply>
            </apply>
         </apply>
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            <eq/>
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               <diff/>
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                  <ci>time</ci>
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               <minus/>
               <apply>
                  <times/>
                  <ci>alpha_m</ci>
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                     <minus/>
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               <apply>
                  <times/>
                  <ci>beta_m</ci>
                  <ci>m</ci>
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            <eq/>
            <ci>i_Nab_jct</ci>
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               <times/>
               <ci>Fx_NaBk_jct</ci>
               <ci>G_NaBk</ci>
               <apply>
                  <minus/>
                  <ci>V</ci>
                  <ci>E_Na_jct</ci>
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            <eq/>
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               <times/>
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               <ci>G_NaBk</ci>
               <apply>
                  <minus/>
                  <ci>V</ci>
                  <ci>E_Na_SL</ci>
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         <apply>
            <eq/>
            <ci>i_Nab</ci>
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               <plus/>
               <ci>i_Nab_jct</ci>
               <ci>i_Nab_SL</ci>
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         </apply>
      </math>
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      <variable name="F" units="coulomb_per_mole" public_interface="in"/>
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      <variable name="Na_jct" units="millimolar" public_interface="in"/>
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      <variable name="Nao" units="millimolar" public_interface="in"/>
      <variable name="Ko" units="millimolar" public_interface="in"/>
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            <eq/>
            <ci>sigma</ci>
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               <divide/>
               <apply>
                  <minus/>
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                     <exp/>
                     <apply>
                        <divide/>
                        <ci>Nao</ci>
                        <cn cellml:units="millimolar">67.3</cn>
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               <cn cellml:units="dimensionless">7</cn>
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            <ci>f_NaK</ci>
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               <divide/>
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               <apply>
                  <plus/>
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                     <times/>
                     <cn cellml:units="dimensionless">0.1245</cn>
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                        <exp/>
                        <apply>
                           <divide/>
                           <apply>
                              <times/>
                              <apply>
                                 <minus/>
                                 <cn cellml:units="dimensionless">0.1</cn>
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                              <ci>V</ci>
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                           <apply>
                              <times/>
                              <ci>R</ci>
                              <ci>T</ci>
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                        </apply>
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                  </apply>
                  <apply>
                     <times/>
                     <cn cellml:units="dimensionless">0.0365</cn>
                     <ci>sigma</ci>
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                        <exp/>
                        <apply>
                           <divide/>
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                              <times/>
                              <apply>
                                 <minus/>
                                 <ci>V</ci>
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                              <ci>F</ci>
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                           <apply>
                              <times/>
                              <ci>R</ci>
                              <ci>T</ci>
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         <apply>
            <eq/>
            <ci>i_NaK_jct</ci>
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               <divide/>
               <apply>
                  <times/>
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                     <divide/>
                     <apply>
                        <times/>
                        <ci>Fx_NaK_jct</ci>
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                        <ci>f_NaK</ci>
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                     <apply>
                        <plus/>
                        <cn cellml:units="dimensionless">1</cn>
                        <apply>
                           <power/>
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                              <divide/>
                              <ci>Km_Nai</ci>
                              <ci>Na_jct</ci>
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                           <ci>H_NaK</ci>
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                  <ci>Ko</ci>
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               <apply>
                  <plus/>
                  <ci>Ko</ci>
                  <ci>Km_Ko</ci>
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         </apply>
         <apply>
            <eq/>
            <ci>i_NaK_SL</ci>
            <apply>
               <divide/>
               <apply>
                  <times/>
                  <apply>
                     <divide/>
                     <apply>
                        <times/>
                        <ci>Fx_NaK_SL</ci>
                        <ci>I_NaK_max</ci>
                        <ci>f_NaK</ci>
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                        <plus/>
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                        <apply>
                           <power/>
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                              <divide/>
                              <ci>Km_Nai</ci>
                              <ci>Na_SL</ci>
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                           <ci>H_NaK</ci>
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                  <ci>Ko</ci>
                  <ci>Km_Ko</ci>
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            <eq/>
            <ci>i_NaK</ci>
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               <plus/>
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               <ci>i_NaK_SL</ci>
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      <variable name="E_K" units="millivolt" public_interface="in"/>
      <variable name="Ko" units="millimolar" public_interface="in"/>
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      <variable name="Rr" units="dimensionless" private_interface="in"/>
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                  <root/>
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               <times/>
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            <eq/>
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               <divide/>
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               <apply>
                  <plus/>
                  <cn cellml:units="dimensionless">1</cn>
                  <apply>
                     <exp/>
                     <apply>
                        <divide/>
                        <apply>
                           <minus/>
                           <apply>
                              <plus/>
                              <cn cellml:units="millivolt">50</cn>
                              <ci>V</ci>
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                        <cn cellml:units="millivolt">7.5</cn>
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                  </apply>
               </apply>
            </apply>
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         <apply>
            <eq/>
            <ci>tau_Xr</ci>
            <apply>
               <divide/>
               <cn cellml:units="millisecond">1</cn>
               <apply>
                  <plus/>
                  <apply>
                     <divide/>
                     <apply>
                        <times/>
                        <cn cellml:units="per_millivolt">0.00138</cn>
                        <apply>
                           <plus/>
                           <ci>V</ci>
                           <cn cellml:units="millivolt">7</cn>
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                     <apply>
                        <minus/>
                        <cn cellml:units="dimensionless">1</cn>
                        <apply>
                           <exp/>
                           <apply>
                              <times/>
                              <apply>
                                 <minus/>
                                 <cn cellml:units="per_millivolt">0.123</cn>
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                              <apply>
                                 <plus/>
                                 <ci>V</ci>
                                 <cn cellml:units="millivolt">7</cn>
                              </apply>
                           </apply>
                        </apply>
                     </apply>
                  </apply>
                  <apply>
                     <divide/>
                     <apply>
                        <times/>
                        <cn cellml:units="per_millivolt">0.00061</cn>
                        <apply>
                           <plus/>
                           <ci>V</ci>
                           <cn cellml:units="millivolt">10</cn>
                        </apply>
                     </apply>
                     <apply>
                        <minus/>
                        <apply>
                           <exp/>
                           <apply>
                              <times/>
                              <cn cellml:units="per_millivolt">0.145</cn>
                              <apply>
                                 <plus/>
                                 <ci>V</ci>
                                 <cn cellml:units="millivolt">10</cn>
                              </apply>
                           </apply>
                        </apply>
                        <cn cellml:units="dimensionless">1</cn>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component xmlns="http://www.cellml.org/cellml/1.0#" name="IKr_Rr_gate">
      <variable name="Rr" units="dimensionless" public_interface="out"/>
      <variable name="V" units="millivolt" public_interface="in"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>Rr</ci>
            <apply>
               <divide/>
               <cn cellml:units="dimensionless">1</cn>
               <apply>
                  <plus/>
                  <cn cellml:units="dimensionless">1</cn>
                  <apply>
                     <exp/>
                     <apply>
                        <divide/>
                        <apply>
                           <plus/>
                           <cn cellml:units="millivolt">33</cn>
                           <ci>V</ci>
                        </apply>
                        <cn cellml:units="millivolt">22.4</cn>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component xmlns="http://www.cellml.org/cellml/1.0#" name="IKs">
      <variable cmeta:id="IKs_i_Ks" name="i_Ks" units="microA_per_microF" public_interface="out"/>
      <variable name="i_Ks_jct" units="microA_per_microF"/>
      <variable name="i_Ks_SL" units="microA_per_microF"/>
      <variable name="G_Ks_SL" units="milliS_per_microF"/>
      <variable name="G_Ks_jct" units="milliS_per_microF"/>
      <variable name="Fx_Ks_jct" units="dimensionless" initial_value="0.11"/>
      <variable name="Fx_Ks_SL" units="dimensionless" initial_value="0.89"/>
      <variable name="E_Ks" units="millivolt"/>
      <variable name="pKNa" units="dimensionless" initial_value="0.01833"/>
      <variable name="pCa_jct" units="dimensionless"/>
      <variable name="pCa_SL" units="dimensionless"/>
      <variable name="R" units="joule_per_kilomole_kelvin" public_interface="in"/>
      <variable name="T" units="kelvin" public_interface="in"/>
      <variable name="F" units="coulomb_per_mole" public_interface="in"/>
      <variable name="Nai" units="millimolar" public_interface="in"/>
      <variable name="Nao" units="millimolar" public_interface="in"/>
      <variable name="Ki" units="millimolar" public_interface="in"/>
      <variable name="Ca_jct" units="millimolar" public_interface="in"/>
      <variable name="Ca_SL" units="millimolar" public_interface="in"/>
      <variable name="Ko" units="millimolar" public_interface="in"/>
      <variable name="time" units="millisecond" public_interface="in" private_interface="out"/>
      <variable name="V" units="millivolt" public_interface="in" private_interface="out"/>
      <variable name="Xs" units="dimensionless" private_interface="in"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>pCa_jct</ci>
            <apply>
               <plus/>
               <apply>
                  <minus/>
                  <apply>
                     <log/>
                     <apply>
                        <divide/>
                        <ci>Ca_jct</ci>
                        <cn cellml:units="millimolar">1</cn>
                     </apply>
                  </apply>
               </apply>
               <cn cellml:units="dimensionless">3</cn>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>pCa_SL</ci>
            <apply>
               <plus/>
               <apply>
                  <minus/>
                  <apply>
                     <log/>
                     <apply>
                        <divide/>
                        <ci>Ca_SL</ci>
                        <cn cellml:units="millimolar">1</cn>
                     </apply>
                  </apply>
               </apply>
               <cn cellml:units="dimensionless">3</cn>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>G_Ks_jct</ci>
            <apply>
               <times/>
               <cn cellml:units="milliS_per_microF">0.07</cn>
               <apply>
                  <plus/>
                  <cn cellml:units="dimensionless">0.057</cn>
                  <apply>
                     <divide/>
                     <cn cellml:units="dimensionless">0.19</cn>
                     <apply>
                        <plus/>
                        <cn cellml:units="dimensionless">1</cn>
                        <apply>
                           <exp/>
                           <apply>
                              <divide/>
                              <apply>
                                 <plus/>
                                 <apply>
                                    <minus/>
                                    <cn cellml:units="dimensionless">7.2</cn>
                                 </apply>
                                 <ci>pCa_jct</ci>
                              </apply>
                              <cn cellml:units="dimensionless">0.6</cn>
                           </apply>
                        </apply>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>G_Ks_SL</ci>
            <apply>
               <times/>
               <cn cellml:units="milliS_per_microF">0.07</cn>
               <apply>
                  <plus/>
                  <cn cellml:units="dimensionless">0.057</cn>
                  <apply>
                     <divide/>
                     <cn cellml:units="dimensionless">0.19</cn>
                     <apply>
                        <plus/>
                        <cn cellml:units="dimensionless">1</cn>
                        <apply>
                           <exp/>
                           <apply>
                              <divide/>
                              <apply>
                                 <plus/>
                                 <apply>
                                    <minus/>
                                    <cn cellml:units="dimensionless">7.2</cn>
                                 </apply>
                                 <ci>pCa_SL</ci>
                              </apply>
                              <cn cellml:units="dimensionless">0.6</cn>
                           </apply>
                        </apply>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>E_Ks</ci>
            <apply>
               <times/>
               <apply>
                  <divide/>
                  <apply>
                     <times/>
                     <ci>R</ci>
                     <ci>T</ci>
                  </apply>
                  <ci>F</ci>
               </apply>
               <apply>
                  <ln/>
                  <apply>
                     <divide/>
                     <apply>
                        <plus/>
                        <ci>Ko</ci>
                        <apply>
                           <times/>
                           <ci>pKNa</ci>
                           <ci>Nao</ci>
                        </apply>
                     </apply>
                     <apply>
                        <plus/>
                        <ci>Ki</ci>
                        <apply>
                           <times/>
                           <ci>pKNa</ci>
                           <ci>Nai</ci>
                        </apply>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>i_Ks_jct</ci>
            <apply>
               <times/>
               <ci>Fx_Ks_jct</ci>
               <ci>G_Ks_jct</ci>
               <apply>
                  <power/>
                  <ci>Xs</ci>
                  <cn cellml:units="dimensionless">2</cn>
               </apply>
               <apply>
                  <minus/>
                  <ci>V</ci>
                  <ci>E_Ks</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>i_Ks_SL</ci>
            <apply>
               <times/>
               <ci>Fx_Ks_SL</ci>
               <ci>G_Ks_SL</ci>
               <apply>
                  <power/>
                  <ci>Xs</ci>
                  <cn cellml:units="dimensionless">2</cn>
               </apply>
               <apply>
                  <minus/>
                  <ci>V</ci>
                  <ci>E_Ks</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>i_Ks</ci>
            <apply>
               <plus/>
               <ci>i_Ks_jct</ci>
               <ci>i_Ks_SL</ci>
            </apply>
         </apply>
      </math>
   </component>
   <component xmlns="http://www.cellml.org/cellml/1.0#" name="IKs_Xs_gate">
      <variable name="Xs" units="dimensionless" initial_value="5.412034e-3" public_interface="out"/>
      <variable name="Xs_infinity" units="dimensionless"/>
      <variable name="tau_Xs" units="millisecond"/>
      <variable name="V" units="millivolt" public_interface="in"/>
      <variable name="time" units="millisecond" public_interface="in"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>Xs</ci>
            </apply>
            <apply>
               <divide/>
               <apply>
                  <minus/>
                  <ci>Xs_infinity</ci>
                  <ci>Xs</ci>
               </apply>
               <ci>tau_Xs</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>Xs_infinity</ci>
            <apply>
               <divide/>
               <cn cellml:units="dimensionless">1</cn>
               <apply>
                  <plus/>
                  <cn cellml:units="dimensionless">1</cn>
                  <apply>
                     <exp/>
                     <apply>
                        <divide/>
                        <apply>
                           <minus/>
                           <apply>
                              <minus/>
                              <ci>V</ci>
                              <cn cellml:units="millivolt">1.5</cn>
                           </apply>
                        </apply>
                        <cn cellml:units="millivolt">16.7</cn>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>tau_Xs</ci>
            <apply>
               <divide/>
               <cn cellml:units="millisecond">1</cn>
               <apply>
                  <plus/>
                  <apply>
                     <divide/>
                     <apply>
                        <times/>
                        <cn type="e-notation" cellml:units="per_millivolt">7.19   <sep/>
                        -5</cn>
                        <apply>
                           <plus/>
                           <ci>V</ci>
                           <cn cellml:units="millivolt">30</cn>
                        </apply>
                     </apply>
                     <apply>
                        <minus/>
                        <cn cellml:units="dimensionless">1</cn>
                        <apply>
                           <exp/>
                           <apply>
                              <times/>
                              <apply>
                                 <minus/>
                                 <cn cellml:units="per_millivolt">0.148</cn>
                              </apply>
                              <apply>
                                 <plus/>
                                 <ci>V</ci>
                                 <cn cellml:units="millivolt">30</cn>
                              </apply>
                           </apply>
                        </apply>
                     </apply>
                  </apply>
                  <apply>
                     <divide/>
                     <apply>
                        <times/>
                        <cn type="e-notation" cellml:units="per_millivolt">1.31   <sep/>
                        -4</cn>
                        <apply>
                           <plus/>
                           <ci>V</ci>
                           <cn cellml:units="millivolt">30</cn>
                        </apply>
                     </apply>
                     <apply>
                        <plus/>
                        <apply>
                           <minus/>
                           <cn cellml:units="dimensionless">1</cn>
                        </apply>
                        <apply>
                           <exp/>
                           <apply>
                              <times/>
                              <cn cellml:units="per_millivolt">0.0687</cn>
                              <apply>
                                 <plus/>
                                 <ci>V</ci>
                                 <cn cellml:units="millivolt">30</cn>
                              </apply>
                           </apply>
                        </apply>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component xmlns="http://www.cellml.org/cellml/1.0#" name="IKp">
      <variable name="i_Kp" units="microA_per_microF" public_interface="out"/>
      <variable name="E_K" units="millivolt" public_interface="in"/>
      <variable name="V" units="millivolt" public_interface="in"/>
      <variable name="g_Kp" units="milliS_per_microF" initial_value="0.001"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>i_Kp</ci>
            <apply>
               <divide/>
               <apply>
                  <times/>
                  <ci>g_Kp</ci>
                  <apply>
                     <minus/>
                     <ci>V</ci>
                     <ci>E_K</ci>
                  </apply>
               </apply>
               <apply>
                  <plus/>
                  <cn cellml:units="dimensionless">1</cn>
                  <apply>
                     <exp/>
                     <apply>
                        <minus/>
                        <cn cellml:units="dimensionless">7.488</cn>
                        <apply>
                           <divide/>
                           <ci>V</ci>
                           <cn cellml:units="millivolt">5.98</cn>
                        </apply>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component xmlns="http://www.cellml.org/cellml/1.0#" name="Itos">
      <variable name="i_tos" units="microA_per_microF" public_interface="out"/>
      <variable name="G_tos" units="milliS_per_microF" initial_value="0.06"/>
      <variable name="V" units="millivolt" public_interface="in" private_interface="out"/>
      <variable name="time" units="millisecond" public_interface="in" private_interface="out"/>
      <variable name="E_K" units="millivolt" public_interface="in"/>
      <variable name="Y_tos" units="dimensionless" private_interface="in"/>
      <variable name="X_tos" units="dimensionless" private_interface="in"/>
      <variable name="R_tos" units="dimensionless" private_interface="in"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>i_tos</ci>
            <apply>
               <times/>
               <ci>G_tos</ci>
               <ci>X_tos</ci>
               <apply>
                  <plus/>
                  <ci>Y_tos</ci>
                  <apply>
                     <times/>
                     <cn cellml:units="dimensionless">0.5</cn>
                     <ci>R_tos</ci>
                  </apply>
               </apply>
               <apply>
                  <minus/>
                  <ci>V</ci>
                  <ci>E_K</ci>
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            </apply>
         </apply>
      </math>
   </component>
   <component xmlns="http://www.cellml.org/cellml/1.0#" name="Itos_X_gate">
      <variable name="X_tos" units="dimensionless" initial_value="4.051574e-3" public_interface="out"/>
      <variable name="X_tos_infinity" units="dimensionless"/>
      <variable name="tau_X_tos" units="millisecond"/>
      <variable name="V" units="millivolt" public_interface="in"/>
      <variable name="time" units="millisecond" public_interface="in"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>X_tos</ci>
            </apply>
            <apply>
               <divide/>
               <apply>
                  <minus/>
                  <ci>X_tos_infinity</ci>
                  <ci>X_tos</ci>
               </apply>
               <ci>tau_X_tos</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>X_tos_infinity</ci>
            <apply>
               <divide/>
               <cn cellml:units="dimensionless">1</cn>
               <apply>
                  <plus/>
                  <cn cellml:units="dimensionless">1</cn>
                  <apply>
                     <exp/>
                     <apply>
                        <divide/>
                        <apply>
                           <minus/>
                           <apply>
                              <plus/>
                              <ci>V</ci>
                              <cn cellml:units="millivolt">3</cn>
                           </apply>
                        </apply>
                        <cn cellml:units="millivolt">15</cn>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>tau_X_tos</ci>
            <apply>
               <plus/>
               <apply>
                  <divide/>
                  <cn cellml:units="millisecond">9</cn>
                  <apply>
                     <plus/>
                     <cn cellml:units="dimensionless">1</cn>
                     <apply>
                        <exp/>
                        <apply>
                           <divide/>
                           <apply>
                              <plus/>
                              <ci>V</ci>
                              <cn cellml:units="millivolt">3</cn>
                           </apply>
                           <cn cellml:units="millivolt">15</cn>
                        </apply>
                     </apply>
                  </apply>
               </apply>
               <cn cellml:units="millisecond">0.5</cn>
            </apply>
         </apply>
      </math>
   </component>
   <component xmlns="http://www.cellml.org/cellml/1.0#" name="Itos_Y_gate">
      <variable name="Y_tos" units="dimensionless" initial_value="9.945511e-1" public_interface="out"/>
      <variable name="Y_tos_infinity" units="dimensionless"/>
      <variable name="tau_Y_tos" units="millisecond"/>
      <variable name="V" units="millivolt" public_interface="in"/>
      <variable name="time" units="millisecond" public_interface="in"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>Y_tos</ci>
            </apply>
            <apply>
               <divide/>
               <apply>
                  <minus/>
                  <ci>Y_tos_infinity</ci>
                  <ci>Y_tos</ci>
               </apply>
               <ci>tau_Y_tos</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>Y_tos_infinity</ci>
            <apply>
               <divide/>
               <cn cellml:units="dimensionless">1</cn>
               <apply>
                  <plus/>
                  <cn cellml:units="dimensionless">1</cn>
                  <apply>
                     <exp/>
                     <apply>
                        <divide/>
                        <apply>
                           <plus/>
                           <ci>V</ci>
                           <cn cellml:units="millivolt">33.5</cn>
                        </apply>
                        <cn cellml:units="millivolt">10</cn>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>tau_Y_tos</ci>
            <apply>
               <plus/>
               <apply>
                  <divide/>
                  <cn cellml:units="millisecond">3000</cn>
                  <apply>
                     <plus/>
                     <cn cellml:units="dimensionless">1</cn>
                     <apply>
                        <exp/>
                        <apply>
                           <divide/>
                           <apply>
                              <plus/>
                              <ci>V</ci>
                              <cn cellml:units="millivolt">60</cn>
                           </apply>
                           <cn cellml:units="millivolt">10</cn>
                        </apply>
                     </apply>
                  </apply>
               </apply>
               <cn cellml:units="millisecond">30</cn>
            </apply>
         </apply>
      </math>
   </component>
   <component xmlns="http://www.cellml.org/cellml/1.0#" name="Itos_R_gate">
      <variable name="R_tos" units="dimensionless" initial_value="0.9946" public_interface="out"/>
      <variable name="R_tos_infinity" units="dimensionless"/>
      <variable name="V" units="millivolt" public_interface="in"/>
      <variable name="tau_R_tos" units="millisecond"/>
      <variable name="time" units="millisecond" public_interface="in"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>R_tos_infinity</ci>
            <apply>
               <divide/>
               <cn cellml:units="dimensionless">1</cn>
               <apply>
                  <plus/>
                  <cn cellml:units="dimensionless">1</cn>
                  <apply>
                     <exp/>
                     <apply>
                        <divide/>
                        <apply>
                           <plus/>
                           <ci>V</ci>
                           <cn cellml:units="millivolt">33.5</cn>
                        </apply>
                        <cn cellml:units="millivolt">10</cn>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>tau_R_tos</ci>
            <apply>
               <plus/>
               <apply>
                  <divide/>
                  <cn type="e-notation" cellml:units="millisecond">2.8   <sep/>
                  3</cn>
                  <apply>
                     <plus/>
                     <cn cellml:units="dimensionless">1</cn>
                     <apply>
                        <exp/>
                        <apply>
                           <divide/>
                           <apply>
                              <plus/>
                              <ci>V</ci>
                              <cn cellml:units="millivolt">60</cn>
                           </apply>
                           <cn cellml:units="millivolt">10</cn>
                        </apply>
                     </apply>
                  </apply>
               </apply>
               <cn cellml:units="millisecond">220</cn>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>R_tos</ci>
            </apply>
            <apply>
               <divide/>
               <apply>
                  <minus/>
                  <ci>R_tos_infinity</ci>
                  <ci>R_tos</ci>
               </apply>
               <ci>tau_R_tos</ci>
            </apply>
         </apply>
      </math>
   </component>
   <component xmlns="http://www.cellml.org/cellml/1.0#" name="Itof">
      <variable cmeta:id="Itof_i_tof" name="i_tof" units="microA_per_microF" public_interface="out"/>
      <variable name="G_tof" units="milliS_per_microF" initial_value="0.02"/>
      <variable name="V" units="millivolt" public_interface="in" private_interface="out"/>
      <variable name="time" units="millisecond" public_interface="in" private_interface="out"/>
      <variable name="E_K" units="millivolt" public_interface="in"/>
      <variable name="Y_tof" units="dimensionless" private_interface="in"/>
      <variable name="X_tof" units="dimensionless" private_interface="in"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>i_tof</ci>
            <apply>
               <times/>
               <ci>G_tof</ci>
               <ci>X_tof</ci>
               <ci>Y_tof</ci>
               <apply>
                  <minus/>
                  <ci>V</ci>
                  <ci>E_K</ci>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component xmlns="http://www.cellml.org/cellml/1.0#" name="Itof_X_gate">
      <variable name="X_tof" units="dimensionless" initial_value="4.051574e-3" public_interface="out"/>
      <variable name="X_tof_infinity" units="dimensionless"/>
      <variable name="tau_X_tof" units="millisecond"/>
      <variable name="V" units="millivolt" public_interface="in"/>
      <variable name="time" units="millisecond" public_interface="in"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>X_tof</ci>
            </apply>
            <apply>
               <divide/>
               <apply>
                  <minus/>
                  <ci>X_tof_infinity</ci>
                  <ci>X_tof</ci>
               </apply>
               <ci>tau_X_tof</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>X_tof_infinity</ci>
            <apply>
               <divide/>
               <cn cellml:units="dimensionless">1</cn>
               <apply>
                  <plus/>
                  <cn cellml:units="dimensionless">1</cn>
                  <apply>
                     <exp/>
                     <apply>
                        <divide/>
                        <apply>
                           <minus/>
                           <apply>
                              <plus/>
                              <ci>V</ci>
                              <cn cellml:units="millivolt">3</cn>
                           </apply>
                        </apply>
                        <cn cellml:units="millivolt">15</cn>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>tau_X_tof</ci>
            <apply>
               <plus/>
               <apply>
                  <times/>
                  <cn cellml:units="millisecond">3.5</cn>
                  <apply>
                     <exp/>
                     <apply>
                        <minus/>
                        <apply>
                           <power/>
                           <apply>
                              <divide/>
                              <ci>V</ci>
                              <cn cellml:units="millivolt">30</cn>
                           </apply>
                           <cn cellml:units="dimensionless">2</cn>
                        </apply>
                     </apply>
                  </apply>
               </apply>
               <cn cellml:units="millisecond">1.5</cn>
            </apply>
         </apply>
      </math>
   </component>
   <component xmlns="http://www.cellml.org/cellml/1.0#" name="Itof_Y_gate">
      <variable name="Y_tof" units="dimensionless" initial_value="9.945511e-1" public_interface="out"/>
      <variable name="Y_tof_infinity" units="dimensionless"/>
      <variable name="tau_Y_tof" units="millisecond"/>
      <variable name="V" units="millivolt" public_interface="in"/>
      <variable name="time" units="millisecond" public_interface="in"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>Y_tof</ci>
            </apply>
            <apply>
               <divide/>
               <apply>
                  <minus/>
                  <ci>Y_tof_infinity</ci>
                  <ci>Y_tof</ci>
               </apply>
               <ci>tau_Y_tof</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>Y_tof_infinity</ci>
            <apply>
               <divide/>
               <cn cellml:units="dimensionless">1</cn>
               <apply>
                  <plus/>
                  <cn cellml:units="dimensionless">1</cn>
                  <apply>
                     <exp/>
                     <apply>
                        <divide/>
                        <apply>
                           <plus/>
                           <ci>V</ci>
                           <cn cellml:units="millivolt">33.5</cn>
                        </apply>
                        <cn cellml:units="millivolt">10</cn>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>tau_Y_tof</ci>
            <apply>
               <plus/>
               <apply>
                  <divide/>
                  <cn cellml:units="millisecond">20</cn>
                  <apply>
                     <plus/>
                     <cn cellml:units="dimensionless">1</cn>
                     <apply>
                        <exp/>
                        <apply>
                           <divide/>
                           <apply>
                              <plus/>
                              <ci>V</ci>
                              <cn cellml:units="millivolt">33.5</cn>
                           </apply>
                           <cn cellml:units="millivolt">10</cn>
                        </apply>
                     </apply>
                  </apply>
               </apply>
               <cn cellml:units="millisecond">20</cn>
            </apply>
         </apply>
      </math>
   </component>
   <component xmlns="http://www.cellml.org/cellml/1.0#" name="IK1">
      <variable cmeta:id="IK1_i_K1" name="i_K1" units="microA_per_microF" public_interface="out"/>
      <variable name="G_K1" units="milliS_per_microF"/>
      <variable name="V" units="millivolt" public_interface="in" private_interface="out"/>
      <variable name="E_K" units="millivolt" public_interface="in" private_interface="out"/>
      <variable name="Ko" units="millimolar" public_interface="in"/>
      <variable name="K1_infinity" units="dimensionless" private_interface="in"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>G_K1</ci>
            <apply>
               <times/>
               <cn cellml:units="milliS_per_microF">0.9</cn>
               <apply>
                  <root/>
                  <apply>
                     <divide/>
                     <ci>Ko</ci>
                     <cn cellml:units="millimolar">5.4</cn>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>i_K1</ci>
            <apply>
               <times/>
               <ci>G_K1</ci>
               <ci>K1_infinity</ci>
               <apply>
                  <minus/>
                  <ci>V</ci>
                  <ci>E_K</ci>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component xmlns="http://www.cellml.org/cellml/1.0#" name="IK1_K1_gate">
      <variable name="K1_infinity" units="dimensionless" public_interface="out"/>
      <variable name="alpha_K1" units="per_millisecond"/>
      <variable name="beta_K1" units="per_millisecond"/>
      <variable name="E_K" units="millivolt" public_interface="in"/>
      <variable name="V" units="millivolt" public_interface="in"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>K1_infinity</ci>
            <apply>
               <divide/>
               <ci>alpha_K1</ci>
               <apply>
                  <plus/>
                  <ci>alpha_K1</ci>
                  <ci>beta_K1</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>alpha_K1</ci>
            <apply>
               <divide/>
               <cn cellml:units="per_millisecond">1.02</cn>
               <apply>
                  <plus/>
                  <cn cellml:units="dimensionless">1</cn>
                  <apply>
                     <exp/>
                     <apply>
                        <times/>
                        <cn cellml:units="per_millivolt">0.2385</cn>
                        <apply>
                           <minus/>
                           <ci>V</ci>
                           <apply>
                              <plus/>
                              <ci>E_K</ci>
                              <cn cellml:units="millivolt">59.215</cn>
                           </apply>
                        </apply>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>beta_K1</ci>
            <apply>
               <divide/>
               <apply>
                  <plus/>
                  <apply>
                     <times/>
                     <cn cellml:units="per_millisecond">0.49124</cn>
                     <apply>
                        <exp/>
                        <apply>
                           <times/>
                           <cn cellml:units="per_millivolt">0.08032</cn>
                           <apply>
                              <plus/>
                              <apply>
                                 <minus/>
                                 <ci>V</ci>
                                 <ci>E_K</ci>
                              </apply>
                              <cn cellml:units="millivolt">5.476</cn>
                           </apply>
                        </apply>
                     </apply>
                  </apply>
                  <apply>
                     <times/>
                     <cn cellml:units="per_millisecond">1</cn>
                     <apply>
                        <exp/>
                        <apply>
                           <times/>
                           <cn cellml:units="per_millivolt">0.06175</cn>
                           <apply>
                              <minus/>
                              <ci>V</ci>
                              <apply>
                                 <plus/>
                                 <ci>E_K</ci>
                                 <cn cellml:units="millivolt">594.31</cn>
                              </apply>
                           </apply>
                        </apply>
                     </apply>
                  </apply>
               </apply>
               <apply>
                  <plus/>
                  <cn cellml:units="dimensionless">1</cn>
                  <apply>
                     <exp/>
                     <apply>
                        <times/>
                        <apply>
                           <minus/>
                           <cn cellml:units="per_millivolt">0.5143</cn>
                        </apply>
                        <apply>
                           <plus/>
                           <apply>
                              <minus/>
                              <ci>V</ci>
                              <ci>E_K</ci>
                           </apply>
                           <cn cellml:units="millivolt">4.753</cn>
                        </apply>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component xmlns="http://www.cellml.org/cellml/1.0#" name="ICl_Ca">
      <variable cmeta:id="ICl_Ca_i_Cl_Ca" name="i_Cl_Ca" units="microA_per_microF" public_interface="out"/>
      <variable name="G_Cl" units="milliS_per_microF" initial_value="0.109625"/>
      <variable name="Kd_ClCa" units="millimolar" initial_value="0.1"/>
      <variable name="Fx_Cl_jct" units="dimensionless" initial_value="0.11"/>
      <variable name="Fx_Cl_SL" units="dimensionless" initial_value="0.89"/>
      <variable name="V" units="millivolt" public_interface="in"/>
      <variable name="E_Cl" units="millivolt" public_interface="in"/>
      <variable name="Ca_jct" units="millimolar" public_interface="in"/>
      <variable name="Ca_SL" units="millimolar" public_interface="in"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>i_Cl_Ca</ci>
            <apply>
               <times/>
               <ci>G_Cl</ci>
               <apply>
                  <minus/>
                  <ci>V</ci>
                  <ci>E_Cl</ci>
               </apply>
               <apply>
                  <plus/>
                  <apply>
                     <divide/>
                     <ci>Fx_Cl_jct</ci>
                     <apply>
                        <plus/>
                        <cn cellml:units="dimensionless">1</cn>
                        <apply>
                           <divide/>
                           <ci>Kd_ClCa</ci>
                           <ci>Ca_jct</ci>
                        </apply>
                     </apply>
                  </apply>
                  <apply>
                     <divide/>
                     <ci>Fx_Cl_SL</ci>
                     <apply>
                        <plus/>
                        <cn cellml:units="dimensionless">1</cn>
                        <apply>
                           <divide/>
                           <ci>Kd_ClCa</ci>
                           <ci>Ca_SL</ci>
                        </apply>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component xmlns="http://www.cellml.org/cellml/1.0#" name="IClb">
      <variable name="i_Clb" units="microA_per_microF" public_interface="out"/>
      <variable name="G_ClBk" units="milliS_per_microF" initial_value="0.009"/>
      <variable name="V" units="millivolt" public_interface="in"/>
      <variable name="E_Cl" units="millivolt" public_interface="in"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>i_Clb</ci>
            <apply>
               <times/>
               <ci>G_ClBk</ci>
               <apply>
                  <minus/>
                  <ci>V</ci>
                  <ci>E_Cl</ci>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component xmlns="http://www.cellml.org/cellml/1.0#" name="ICaL">
      <variable cmeta:id="ICaL_i_CaL" name="i_CaL" units="microA_per_microF" public_interface="out"/>
      <variable name="i_CaL_Ca_SL" units="microA_per_microF" public_interface="out"/>
      <variable name="i_CaL_Ca_jct" units="microA_per_microF" public_interface="out"/>
      <variable name="i_CaL_Na_SL" units="microA_per_microF" public_interface="out"/>
      <variable name="i_CaL_Na_jct" units="microA_per_microF" public_interface="out"/>
      <variable name="i_CaL_K" units="microA_per_microF"/>
      <variable name="PCa" units="litre_per_farad_millisecond" initial_value="5.4e-4"/>
      <variable name="PNa" units="litre_per_farad_millisecond" initial_value="1.5e-8"/>
      <variable name="PK" units="litre_per_farad_millisecond" initial_value="2.7e-7"/>
      <variable name="Fx_ICaL_jct" units="dimensionless" initial_value="0.9"/>
      <variable name="Fx_ICaL_SL" units="dimensionless" initial_value="0.1"/>
      <variable name="gamma_Cai" units="dimensionless" initial_value="0.341"/>
      <variable name="gamma_Cao" units="dimensionless" initial_value="0.341"/>
      <variable name="gamma_Nai" units="dimensionless" initial_value="0.75"/>
      <variable name="gamma_Nao" units="dimensionless" initial_value="0.75"/>
      <variable name="gamma_Ki" units="dimensionless" initial_value="0.75"/>
      <variable name="gamma_Ko" units="dimensionless" initial_value="0.75"/>
      <variable name="Q10_CaL" units="dimensionless" initial_value="1.8"/>
      <variable name="Q_CaL" units="dimensionless"/>
      <variable name="V" units="millivolt" public_interface="in" private_interface="out"/>
      <variable name="time" units="millisecond" public_interface="in" private_interface="out"/>
      <variable name="Cai" units="millimolar" public_interface="in" private_interface="out"/>
      <variable name="Na_SL" units="millimolar" public_interface="in"/>
      <variable name="Na_jct" units="millimolar" public_interface="in"/>
      <variable name="Nao" units="millimolar" public_interface="in"/>
      <variable name="Ca_SL" units="millimolar" public_interface="in" private_interface="out"/>
      <variable name="Ca_jct" units="millimolar" public_interface="in" private_interface="out"/>
      <variable name="Cao" units="millimolar" public_interface="in"/>
      <variable name="Ki" units="millimolar" public_interface="in"/>
      <variable name="Ko" units="millimolar" public_interface="in"/>
      <variable name="R" units="joule_per_kilomole_kelvin" public_interface="in"/>
      <variable name="T" units="kelvin" public_interface="in"/>
      <variable name="F" units="coulomb_per_mole" public_interface="in"/>
      <variable name="d" units="dimensionless" private_interface="in"/>
      <variable name="f" units="dimensionless" private_interface="in"/>
      <variable name="fCa_SL" units="dimensionless" private_interface="in"/>
      <variable name="fCa_jct" units="dimensionless" private_interface="in"/>
      <variable name="temp" units="coulomb_per_mole"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>Q_CaL</ci>
            <apply>
               <power/>
               <ci>Q10_CaL</ci>
               <apply>
                  <divide/>
                  <apply>
                     <minus/>
                     <ci>T</ci>
                     <cn cellml:units="kelvin">310</cn>
                  </apply>
                  <cn cellml:units="kelvin">10</cn>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>temp</ci>
            <apply>
               <divide/>
               <apply>
                  <times/>
                  <cn cellml:units="dimensionless">0.45</cn>
                  <ci>d</ci>
                  <ci>f</ci>
                  <ci>Q_CaL</ci>
                  <ci>V</ci>
                  <apply>
                     <power/>
                     <ci>F</ci>
                     <cn cellml:units="dimensionless">2</cn>
                  </apply>
               </apply>
               <apply>
                  <times/>
                  <ci>R</ci>
                  <ci>T</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>i_CaL_Ca_jct</ci>
            <apply>
               <divide/>
               <apply>
                  <times/>
                  <ci>temp</ci>
                  <ci>fCa_jct</ci>
                  <ci>Fx_ICaL_jct</ci>
                  <ci>PCa</ci>
                  <cn cellml:units="dimensionless">4</cn>
                  <apply>
                     <minus/>
                     <apply>
                        <times/>
                        <ci>gamma_Cai</ci>
                        <ci>Ca_jct</ci>
                        <apply>
                           <exp/>
                           <apply>
                              <divide/>
                              <apply>
                                 <times/>
                                 <cn cellml:units="dimensionless">2</cn>
                                 <ci>V</ci>
                                 <ci>F</ci>
                              </apply>
                              <apply>
                                 <times/>
                                 <ci>R</ci>
                                 <ci>T</ci>
                              </apply>
                           </apply>
                        </apply>
                     </apply>
                     <apply>
                        <times/>
                        <ci>gamma_Cao</ci>
                        <ci>Cao</ci>
                     </apply>
                  </apply>
               </apply>
               <apply>
                  <minus/>
                  <apply>
                     <exp/>
                     <apply>
                        <divide/>
                        <apply>
                           <times/>
                           <cn cellml:units="dimensionless">2</cn>
                           <ci>V</ci>
                           <ci>F</ci>
                        </apply>
                        <apply>
                           <times/>
                           <ci>R</ci>
                           <ci>T</ci>
                        </apply>
                     </apply>
                  </apply>
                  <cn cellml:units="dimensionless">1</cn>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>i_CaL_Na_jct</ci>
            <apply>
               <divide/>
               <apply>
                  <times/>
                  <ci>temp</ci>
                  <ci>fCa_jct</ci>
                  <ci>Fx_ICaL_jct</ci>
                  <ci>PNa</ci>
                  <apply>
                     <minus/>
                     <apply>
                        <times/>
                        <ci>gamma_Nai</ci>
                        <ci>Na_jct</ci>
                        <apply>
                           <exp/>
                           <apply>
                              <divide/>
                              <apply>
                                 <times/>
                                 <ci>V</ci>
                                 <ci>F</ci>
                              </apply>
                              <apply>
                                 <times/>
                                 <ci>R</ci>
                                 <ci>T</ci>
                              </apply>
                           </apply>
                        </apply>
                     </apply>
                     <apply>
                        <times/>
                        <ci>gamma_Nao</ci>
                        <ci>Nao</ci>
                     </apply>
                  </apply>
               </apply>
               <apply>
                  <minus/>
                  <apply>
                     <exp/>
                     <apply>
                        <divide/>
                        <apply>
                           <times/>
                           <ci>V</ci>
                           <ci>F</ci>
                        </apply>
                        <apply>
                           <times/>
                           <ci>R</ci>
                           <ci>T</ci>
                        </apply>
                     </apply>
                  </apply>
                  <cn cellml:units="dimensionless">1</cn>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>i_CaL_Ca_SL</ci>
            <apply>
               <divide/>
               <apply>
                  <times/>
                  <ci>temp</ci>
                  <ci>fCa_SL</ci>
                  <ci>Fx_ICaL_SL</ci>
                  <ci>PCa</ci>
                  <cn cellml:units="dimensionless">4</cn>
                  <apply>
                     <minus/>
                     <apply>
                        <times/>
                        <ci>gamma_Cai</ci>
                        <ci>Ca_SL</ci>
                        <apply>
                           <exp/>
                           <apply>
                              <divide/>
                              <apply>
                                 <times/>
                                 <cn cellml:units="dimensionless">2</cn>
                                 <ci>V</ci>
                                 <ci>F</ci>
                              </apply>
                              <apply>
                                 <times/>
                                 <ci>R</ci>
                                 <ci>T</ci>
                              </apply>
                           </apply>
                        </apply>
                     </apply>
                     <apply>
                        <times/>
                        <ci>gamma_Cao</ci>
                        <ci>Cao</ci>
                     </apply>
                  </apply>
               </apply>
               <apply>
                  <minus/>
                  <apply>
                     <exp/>
                     <apply>
                        <divide/>
                        <apply>
                           <times/>
                           <cn cellml:units="dimensionless">2</cn>
                           <ci>V</ci>
                           <ci>F</ci>
                        </apply>
                        <apply>
                           <times/>
                           <ci>R</ci>
                           <ci>T</ci>
                        </apply>
                     </apply>
                  </apply>
                  <cn cellml:units="dimensionless">1</cn>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>i_CaL_Na_SL</ci>
            <apply>
               <divide/>
               <apply>
                  <times/>
                  <ci>temp</ci>
                  <ci>fCa_SL</ci>
                  <ci>Fx_ICaL_SL</ci>
                  <ci>PNa</ci>
                  <apply>
                     <minus/>
                     <apply>
                        <times/>
                        <ci>gamma_Nai</ci>
                        <ci>Na_SL</ci>
                        <apply>
                           <exp/>
                           <apply>
                              <divide/>
                              <apply>
                                 <times/>
                                 <ci>V</ci>
                                 <ci>F</ci>
                              </apply>
                              <apply>
                                 <times/>
                                 <ci>R</ci>
                                 <ci>T</ci>
                              </apply>
                           </apply>
                        </apply>
                     </apply>
                     <apply>
                        <times/>
                        <ci>gamma_Nao</ci>
                        <ci>Nao</ci>
                     </apply>
                  </apply>
               </apply>
               <apply>
                  <minus/>
                  <apply>
                     <exp/>
                     <apply>
                        <divide/>
                        <apply>
                           <times/>
                           <ci>V</ci>
                           <ci>F</ci>
                        </apply>
                        <apply>
                           <times/>
                           <ci>R</ci>
                           <ci>T</ci>
                        </apply>
                     </apply>
                  </apply>
                  <cn cellml:units="dimensionless">1</cn>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>i_CaL_K</ci>
            <apply>
               <divide/>
               <apply>
                  <times/>
                  <ci>temp</ci>
                  <apply>
                     <plus/>
                     <apply>
                        <times/>
                        <ci>fCa_SL</ci>
                        <ci>Fx_ICaL_SL</ci>
                     </apply>
                     <apply>
                        <times/>
                        <ci>fCa_jct</ci>
                        <ci>Fx_ICaL_jct</ci>
                     </apply>
                  </apply>
                  <ci>PK</ci>
                  <apply>
                     <minus/>
                     <apply>
                        <times/>
                        <ci>gamma_Ki</ci>
                        <ci>Ki</ci>
                        <apply>
                           <exp/>
                           <apply>
                              <divide/>
                              <apply>
                                 <times/>
                                 <ci>V</ci>
                                 <ci>F</ci>
                              </apply>
                              <apply>
                                 <times/>
                                 <ci>R</ci>
                                 <ci>T</ci>
                              </apply>
                           </apply>
                        </apply>
                     </apply>
                     <apply>
                        <times/>
                        <ci>gamma_Ko</ci>
                        <ci>Ko</ci>
                     </apply>
                  </apply>
               </apply>
               <apply>
                  <minus/>
                  <apply>
                     <exp/>
                     <apply>
                        <divide/>
                        <apply>
                           <times/>
                           <ci>V</ci>
                           <ci>F</ci>
                        </apply>
                        <apply>
                           <times/>
                           <ci>R</ci>
                           <ci>T</ci>
                        </apply>
                     </apply>
                  </apply>
                  <cn cellml:units="dimensionless">1</cn>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>i_CaL</ci>
            <apply>
               <plus/>
               <ci>i_CaL_Ca_SL</ci>
               <ci>i_CaL_Ca_jct</ci>
               <ci>i_CaL_Na_SL</ci>
               <ci>i_CaL_Na_jct</ci>
               <ci>i_CaL_K</ci>
            </apply>
         </apply>
      </math>
   </component>
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      <variable name="d" units="dimensionless" initial_value="7.175662e-6" public_interface="out"/>
      <variable name="d_infinity" units="dimensionless"/>
      <variable name="tau_d" units="millisecond"/>
      <variable name="V" units="millivolt" public_interface="in"/>
      <variable name="time" units="millisecond" public_interface="in"/>
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            <ci>d_infinity</ci>
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               <divide/>
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                  <cn cellml:units="dimensionless">1</cn>
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                     <apply>
                        <divide/>
                        <apply>
                           <minus/>
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                              <plus/>
                              <ci>V</ci>
                              <cn cellml:units="millivolt">14.5</cn>
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                        <cn cellml:units="millivolt">6</cn>
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                  </apply>
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            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>tau_d</ci>
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               <divide/>
               <apply>
                  <times/>
                  <cn cellml:units="millisecond">1</cn>
                  <ci>d_infinity</ci>
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                     <minus/>
                     <cn cellml:units="dimensionless">1</cn>
                     <apply>
                        <exp/>
                        <apply>
                           <divide/>
                           <apply>
                              <minus/>
                              <apply>
                                 <plus/>
                                 <ci>V</ci>
                                 <cn cellml:units="millivolt">14.5</cn>
                              </apply>
                           </apply>
                           <cn cellml:units="millivolt">6</cn>
                        </apply>
                     </apply>
                  </apply>
               </apply>
               <apply>
                  <times/>
                  <cn cellml:units="per_millivolt">0.035</cn>
                  <apply>
                     <plus/>
                     <ci>V</ci>
                     <cn cellml:units="millivolt">14.5</cn>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>d</ci>
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            <apply>
               <divide/>
               <apply>
                  <minus/>
                  <ci>d_infinity</ci>
                  <ci>d</ci>
               </apply>
               <ci>tau_d</ci>
            </apply>
         </apply>
      </math>
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      <variable name="f" units="dimensionless" initial_value="1.000681" public_interface="out"/>
      <variable name="f_infinity" units="dimensionless"/>
      <variable name="tau_f" units="millisecond"/>
      <variable name="V" units="millivolt" public_interface="in"/>
      <variable name="time" units="millisecond" public_interface="in"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>f_infinity</ci>
            <apply>
               <plus/>
               <apply>
                  <divide/>
                  <cn cellml:units="dimensionless">1</cn>
                  <apply>
                     <plus/>
                     <cn cellml:units="dimensionless">1</cn>
                     <apply>
                        <exp/>
                        <apply>
                           <divide/>
                           <apply>
                              <plus/>
                              <ci>V</ci>
                              <cn cellml:units="millivolt">35.06</cn>
                           </apply>
                           <cn cellml:units="millivolt">3.6</cn>
                        </apply>
                     </apply>
                  </apply>
               </apply>
               <apply>
                  <divide/>
                  <cn cellml:units="dimensionless">0.6</cn>
                  <apply>
                     <plus/>
                     <cn cellml:units="dimensionless">1</cn>
                     <apply>
                        <exp/>
                        <apply>
                           <divide/>
                           <apply>
                              <minus/>
                              <cn cellml:units="millivolt">50</cn>
                              <ci>V</ci>
                           </apply>
                           <cn cellml:units="millivolt">20</cn>
                        </apply>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>tau_f</ci>
            <apply>
               <divide/>
               <cn cellml:units="millisecond">1</cn>
               <apply>
                  <plus/>
                  <apply>
                     <times/>
                     <cn cellml:units="dimensionless">0.0197</cn>
                     <apply>
                        <exp/>
                        <apply>
                           <minus/>
                           <apply>
                              <power/>
                              <apply>
                                 <times/>
                                 <cn cellml:units="per_millivolt">0.0337</cn>
                                 <apply>
                                    <plus/>
                                    <ci>V</ci>
                                    <cn cellml:units="millivolt">14.5</cn>
                                 </apply>
                              </apply>
                              <cn cellml:units="dimensionless">2</cn>
                           </apply>
                        </apply>
                     </apply>
                  </apply>
                  <cn cellml:units="dimensionless">0.02</cn>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>f</ci>
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            <apply>
               <divide/>
               <apply>
                  <minus/>
                  <ci>f_infinity</ci>
                  <ci>f</ci>
               </apply>
               <ci>tau_f</ci>
            </apply>
         </apply>
      </math>
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      <variable name="fCa_SL" units="dimensionless" public_interface="out"/>
      <variable name="fCa_jct" units="dimensionless" public_interface="out"/>
      <variable name="fCaB_SL" units="dimensionless" initial_value="1.452605e-2" public_interface="out"/>
      <variable name="fCaB_jct" units="dimensionless" initial_value="2.421991e-2" public_interface="out"/>
      <variable name="Ca_SL" units="millimolar" public_interface="in"/>
      <variable name="Ca_jct" units="millimolar" public_interface="in"/>
      <variable name="time" units="millisecond" public_interface="in"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>fCa_SL</ci>
            <apply>
               <minus/>
               <cn cellml:units="dimensionless">1</cn>
               <ci>fCaB_SL</ci>
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         </apply>
         <apply>
            <eq/>
            <ci>fCa_jct</ci>
            <apply>
               <minus/>
               <cn cellml:units="dimensionless">1</cn>
               <ci>fCaB_jct</ci>
            </apply>
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         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
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               <ci>fCaB_SL</ci>
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            <apply>
               <minus/>
               <apply>
                  <times/>
                  <cn cellml:units="per_millimolar_millisecond">1.7</cn>
                  <ci>Ca_SL</ci>
                  <apply>
                     <minus/>
                     <cn cellml:units="dimensionless">1</cn>
                     <ci>fCaB_SL</ci>
                  </apply>
               </apply>
               <apply>
                  <times/>
                  <cn type="e-notation" cellml:units="per_millisecond">11.9   <sep/>
                  -3</cn>
                  <ci>fCaB_SL</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>fCaB_jct</ci>
            </apply>
            <apply>
               <minus/>
               <apply>
                  <times/>
                  <cn cellml:units="per_millimolar_millisecond">1.7</cn>
                  <ci>Ca_jct</ci>
                  <apply>
                     <minus/>
                     <cn cellml:units="dimensionless">1</cn>
                     <ci>fCaB_jct</ci>
                  </apply>
               </apply>
               <apply>
                  <times/>
                  <cn type="e-notation" cellml:units="per_millisecond">11.9   <sep/>
                  -3</cn>
                  <ci>fCaB_jct</ci>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component xmlns="http://www.cellml.org/cellml/1.0#" name="INaCa">
      <variable cmeta:id="INaCa_i_NaCa" name="i_NaCa" units="microA_per_microF" public_interface="out"/>
      <variable name="i_NaCa_SL" units="microA_per_microF" public_interface="out"/>
      <variable name="i_NaCa_jct" units="microA_per_microF" public_interface="out"/>
      <variable name="V_max" units="microA_per_microF" initial_value="9"/>
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      <variable name="Q_NCX" units="dimensionless"/>
      <variable name="K_mNai" units="millimolar" initial_value="12.29"/>
      <variable name="K_mCao" units="millimolar" initial_value="1.3"/>
      <variable name="K_mNao" units="millimolar" initial_value="87.5"/>
      <variable name="K_mCai" units="millimolar" initial_value="0.00359"/>
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      <variable name="Ka_jct" units="dimensionless"/>
      <variable name="Kd_act" units="millimolar" initial_value="0.000256"/>
      <variable name="ksat" units="dimensionless" initial_value="0.27"/>
      <variable name="eta" units="dimensionless" initial_value="0.35"/>
      <variable name="HNa" units="dimensionless" initial_value="3"/>
      <variable name="V" units="millivolt" public_interface="in"/>
      <variable name="R" units="joule_per_kilomole_kelvin" public_interface="in"/>
      <variable name="T" units="kelvin" public_interface="in"/>
      <variable name="F" units="coulomb_per_mole" public_interface="in"/>
      <variable name="Nai" units="millimolar" public_interface="in"/>
      <variable name="Na_SL" units="millimolar" public_interface="in"/>
      <variable name="Na_jct" units="millimolar" public_interface="in"/>
      <variable name="Nao" units="millimolar" public_interface="in"/>
      <variable name="Cai" units="millimolar" public_interface="in"/>
      <variable name="Ca_SL" units="millimolar" public_interface="in"/>
      <variable name="Ca_jct" units="millimolar" public_interface="in"/>
      <variable name="Cao" units="millimolar" public_interface="in"/>
      <variable name="temp_jct" units="millimolar4"/>
      <variable name="temp_SL" units="millimolar4"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>temp_jct</ci>
            <apply>
               <divide/>
               <apply>
                  <minus/>
                  <apply>
                     <times/>
                     <apply>
                        <exp/>
                        <apply>
                           <divide/>
                           <apply>
                              <times/>
                              <ci>eta</ci>
                              <ci>V</ci>
                              <ci>F</ci>
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                           <apply>
                              <times/>
                              <ci>R</ci>
                              <ci>T</ci>
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                        </apply>
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                     <apply>
                        <power/>
                        <ci>Na_jct</ci>
                        <ci>HNa</ci>
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                     <ci>Cao</ci>
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                  <apply>
                     <times/>
                     <apply>
                        <exp/>
                        <apply>
                           <divide/>
                           <apply>
                              <times/>
                              <apply>
                                 <minus/>
                                 <ci>eta</ci>
                                 <cn cellml:units="dimensionless">1</cn>
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                              <ci>V</ci>
                              <ci>F</ci>
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                           <apply>
                              <times/>
                              <ci>R</ci>
                              <ci>T</ci>
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                        </apply>
                     </apply>
                     <apply>
                        <power/>
                        <ci>Nao</ci>
                        <ci>HNa</ci>
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                     <ci>Ca_jct</ci>
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               </apply>
               <apply>
                  <plus/>
                  <cn cellml:units="dimensionless">1</cn>
                  <apply>
                     <times/>
                     <ci>ksat</ci>
                     <apply>
                        <exp/>
                        <apply>
                           <divide/>
                           <apply>
                              <times/>
                              <apply>
                                 <minus/>
                                 <ci>eta</ci>
                                 <cn cellml:units="dimensionless">1</cn>
                              </apply>
                              <ci>V</ci>
                              <ci>F</ci>
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                           <apply>
                              <times/>
                              <ci>R</ci>
                              <ci>T</ci>
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                        </apply>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>temp_SL</ci>
            <apply>
               <divide/>
               <apply>
                  <minus/>
                  <apply>
                     <times/>
                     <apply>
                        <exp/>
                        <apply>
                           <divide/>
                           <apply>
                              <times/>
                              <ci>eta</ci>
                              <ci>V</ci>
                              <ci>F</ci>
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                           <apply>
                              <times/>
                              <ci>R</ci>
                              <ci>T</ci>
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                        </apply>
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                     <apply>
                        <power/>
                        <ci>Na_SL</ci>
                        <ci>HNa</ci>
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                     <ci>Cao</ci>
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                  <apply>
                     <times/>
                     <apply>
                        <exp/>
                        <apply>
                           <divide/>
                           <apply>
                              <times/>
                              <apply>
                                 <minus/>
                                 <ci>eta</ci>
                                 <cn cellml:units="dimensionless">1</cn>
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                              <ci>V</ci>
                              <ci>F</ci>
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                           <apply>
                              <times/>
                              <ci>R</ci>
                              <ci>T</ci>
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                        </apply>
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                     <apply>
                        <power/>
                        <ci>Nao</ci>
                        <ci>HNa</ci>
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                     <ci>Ca_SL</ci>
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               <apply>
                  <plus/>
                  <cn cellml:units="dimensionless">1</cn>
                  <apply>
                     <times/>
                     <ci>ksat</ci>
                     <apply>
                        <exp/>
                        <apply>
                           <divide/>
                           <apply>
                              <times/>
                              <apply>
                                 <minus/>
                                 <ci>eta</ci>
                                 <cn cellml:units="dimensionless">1</cn>
                              </apply>
                              <ci>V</ci>
                              <ci>F</ci>
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                           <apply>
                              <times/>
                              <ci>R</ci>
                              <ci>T</ci>
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                        </apply>
                     </apply>
                  </apply>
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         <apply>
            <eq/>
            <ci>Q_NCX</ci>
            <apply>
               <power/>
               <ci>Q10_NCX</ci>
               <apply>
                  <divide/>
                  <apply>
                     <minus/>
                     <ci>T</ci>
                     <cn cellml:units="kelvin">310</cn>
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                  <cn cellml:units="kelvin">10</cn>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>Ka_SL</ci>
            <apply>
               <divide/>
               <cn cellml:units="dimensionless">1</cn>
               <apply>
                  <plus/>
                  <cn cellml:units="dimensionless">1</cn>
                  <apply>
                     <power/>
                     <apply>
                        <divide/>
                        <ci>Kd_act</ci>
                        <ci>Ca_SL</ci>
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                     <cn cellml:units="dimensionless">3</cn>
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               </apply>
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         <apply>
            <eq/>
            <ci>Ka_jct</ci>
            <apply>
               <divide/>
               <cn cellml:units="dimensionless">1</cn>
               <apply>
                  <plus/>
                  <cn cellml:units="dimensionless">1</cn>
                  <apply>
                     <power/>
                     <apply>
                        <divide/>
                        <ci>Kd_act</ci>
                        <ci>Ca_jct</ci>
                     </apply>
                     <cn cellml:units="dimensionless">3</cn>
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         <apply>
            <eq/>
            <ci>i_NaCa_jct</ci>
            <apply>
               <divide/>
               <apply>
                  <times/>
                  <ci>Fx_NCX_jct</ci>
                  <ci>V_max</ci>
                  <ci>Ka_jct</ci>
                  <ci>Q_NCX</ci>
                  <ci>temp_jct</ci>
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                  <plus/>
                  <apply>
                     <times/>
                     <ci>K_mCai</ci>
                     <apply>
                        <power/>
                        <ci>Nao</ci>
                        <ci>HNa</ci>
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                     <apply>
                        <plus/>
                        <cn cellml:units="dimensionless">1</cn>
                        <apply>
                           <power/>
                           <apply>
                              <divide/>
                              <ci>Na_jct</ci>
                              <ci>K_mNai</ci>
                           </apply>
                           <ci>HNa</ci>
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                     </apply>
                  </apply>
                  <apply>
                     <times/>
                     <apply>
                        <power/>
                        <ci>K_mNao</ci>
                        <ci>HNa</ci>
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                     <ci>Ca_jct</ci>
                     <apply>
                        <plus/>
                        <cn cellml:units="dimensionless">1</cn>
                        <apply>
                           <divide/>
                           <ci>Ca_jct</ci>
                           <ci>K_mCai</ci>
                        </apply>
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                  <apply>
                     <times/>
                     <ci>K_mCao</ci>
                     <apply>
                        <power/>
                        <ci>Na_jct</ci>
                        <ci>HNa</ci>
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                  </apply>
                  <apply>
                     <times/>
                     <apply>
                        <power/>
                        <ci>Na_jct</ci>
                        <ci>HNa</ci>
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                     <ci>Cao</ci>
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                  <apply>
                     <times/>
                     <apply>
                        <power/>
                        <ci>Nao</ci>
                        <ci>HNa</ci>
                     </apply>
                     <ci>Ca_jct</ci>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>i_NaCa_SL</ci>
            <apply>
               <divide/>
               <apply>
                  <times/>
                  <ci>Fx_NCX_SL</ci>
                  <ci>V_max</ci>
                  <ci>Ka_SL</ci>
                  <ci>Q_NCX</ci>
                  <ci>temp_SL</ci>
               </apply>
               <apply>
                  <plus/>
                  <apply>
                     <times/>
                     <ci>K_mCai</ci>
                     <apply>
                        <power/>
                        <ci>Nao</ci>
                        <ci>HNa</ci>
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                     <apply>
                        <plus/>
                        <cn cellml:units="dimensionless">1</cn>
                        <apply>
                           <power/>
                           <apply>
                              <divide/>
                              <ci>Na_SL</ci>
                              <ci>K_mNai</ci>
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                           <ci>HNa</ci>
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                     </apply>
                  </apply>
                  <apply>
                     <times/>
                     <apply>
                        <power/>
                        <ci>K_mNao</ci>
                        <ci>HNa</ci>
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                     <ci>Ca_SL</ci>
                     <apply>
                        <plus/>
                        <cn cellml:units="dimensionless">1</cn>
                        <apply>
                           <divide/>
                           <ci>Ca_SL</ci>
                           <ci>K_mCai</ci>
                        </apply>
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                  <apply>
                     <times/>
                     <ci>K_mCao</ci>
                     <apply>
                        <power/>
                        <ci>Na_SL</ci>
                        <ci>HNa</ci>
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                  <apply>
                     <times/>
                     <apply>
                        <power/>
                        <ci>Na_SL</ci>
                        <ci>HNa</ci>
                     </apply>
                     <ci>Cao</ci>
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                  <apply>
                     <times/>
                     <apply>
                        <power/>
                        <ci>Nao</ci>
                        <ci>HNa</ci>
                     </apply>
                     <ci>Ca_SL</ci>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>i_NaCa</ci>
            <apply>
               <plus/>
               <ci>i_NaCa_jct</ci>
               <ci>i_NaCa_SL</ci>
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         </apply>
      </math>
   </component>
   <component xmlns="http://www.cellml.org/cellml/1.0#" name="ICap">
      <variable name="i_Cap" units="microA_per_microF" public_interface="out"/>
      <variable name="i_Cap_SL" units="microA_per_microF" public_interface="out"/>
      <variable name="i_Cap_jct" units="microA_per_microF" public_interface="out"/>
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      <variable name="Q10_SLCaP" units="dimensionless" initial_value="2.35"/>
      <variable name="Q_SLCaP" units="dimensionless"/>
      <variable name="Km" units="millimolar" initial_value="0.0005"/>
      <variable name="H" units="dimensionless" initial_value="1.6"/>
      <variable name="Cai" units="millimolar" public_interface="in"/>
      <variable name="Ca_SL" units="millimolar" public_interface="in"/>
      <variable name="Ca_jct" units="millimolar" public_interface="in"/>
      <variable name="T" units="kelvin" public_interface="in"/>
      <variable name="F" units="coulomb_per_mole" public_interface="in"/>
      <variable name="Vol_myo" units="litre" public_interface="in"/>
      <variable name="Cm" units="farad" public_interface="in"/>
      <variable name="V_maxAF" units="microA_per_microF" initial_value="0.0673"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>Q_SLCaP</ci>
            <apply>
               <power/>
               <ci>Q10_SLCaP</ci>
               <apply>
                  <divide/>
                  <apply>
                     <minus/>
                     <ci>T</ci>
                     <cn cellml:units="kelvin">310</cn>
                  </apply>
                  <cn cellml:units="kelvin">10</cn>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>i_Cap_jct</ci>
            <apply>
               <divide/>
               <apply>
                  <times/>
                  <ci>Q_SLCaP</ci>
                  <ci>V_maxAF</ci>
                  <ci>Fx_SLCaP_jct</ci>
               </apply>
               <apply>
                  <plus/>
                  <cn cellml:units="dimensionless">1</cn>
                  <apply>
                     <power/>
                     <apply>
                        <divide/>
                        <ci>Km</ci>
                        <ci>Ca_jct</ci>
                     </apply>
                     <ci>H</ci>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>i_Cap_SL</ci>
            <apply>
               <divide/>
               <apply>
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                  <ci>Q_SLCaP</ci>
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      <variable name="Ca_SLHigh_SL" units="millimolar" initial_value="7.297378e-2" public_interface="out"/>
      <variable name="Ca_SLHigh_jct" units="millimolar" initial_value="7.347888e-3" public_interface="out"/>
      <variable name="Ca_Calsequestrin" units="millimolar" initial_value="1.242988" public_interface="out"/>
      <variable name="Bmax_SLB_SL" units="millimolar" initial_value="0.0374"/>
      <variable name="Bmax_SLB_jct" units="millimolar" initial_value="0.0046"/>
      <variable name="Bmax_SLHigh_SL" units="millimolar" initial_value="0.0134"/>
      <variable name="Bmax_SLHigh_jct" units="millimolar" initial_value="0.00165"/>
      <variable name="Bmax_Calsequestrin" units="millimolar" initial_value="0.14"/>
      <variable name="kon_SL" units="per_millimolar_per_millisecond" initial_value="100"/>
      <variable name="kon_Calsequestrin" units="per_millimolar_per_millisecond" initial_value="100"/>
      <variable name="koff_SLB" units="per_millisecond" initial_value="1.3"/>
      <variable name="koff_SLHigh" units="per_millisecond" initial_value="30e-3"/>
      <variable name="koff_Calsequestrin" units="per_millisecond" initial_value="65"/>
      <variable name="i_CaL_Ca_jct" units="microA_per_microF" public_interface="in"/>
      <variable name="i_NaCa_jct" units="microA_per_microF" public_interface="in"/>
      <variable name="i_Cab_jct" units="microA_per_microF" public_interface="in"/>
      <variable name="i_Cap_jct" units="microA_per_microF" public_interface="in"/>
      <variable name="i_CaL_Ca_SL" units="microA_per_microF" public_interface="in"/>
      <variable name="i_NaCa_SL" units="microA_per_microF" public_interface="in"/>
      <variable name="i_Cab_SL" units="microA_per_microF" public_interface="in"/>
      <variable name="i_Cap_SL" units="microA_per_microF" public_interface="in"/>
      <variable name="j_pump_SR" units="millimolar_per_millisecond" public_interface="in"/>
      <variable name="j_rel_SR" units="millimolar_per_millisecond" public_interface="in"/>
      <variable name="j_leak_SR" units="millimolar_per_millisecond" public_interface="in"/>
      <variable name="J_Ca_jct_SL" units="millimole_per_millisecond" public_interface="in"/>
      <variable name="J_Ca_SL_myo" units="millimole_per_millisecond" public_interface="in"/>
      <variable name="Vol_SR" units="litre" public_interface="in"/>
      <variable name="Vol_SL" units="litre" public_interface="in" private_interface="out"/>
      <variable name="Vol_jct" units="litre" public_interface="in" private_interface="out"/>
      <variable name="Vol_myo" units="litre" public_interface="in" private_interface="out"/>
      <variable name="F" units="coulomb_per_mole" public_interface="in"/>
      <variable name="Cm" units="farad" public_interface="in"/>
      <variable name="time" units="millisecond" public_interface="in" private_interface="out"/>
      <variable name="dCalsequestrin" units="millimolar_per_millisecond"/>
      <variable name="dCa_cytosol_tot_bound" units="millimolar_per_millisecond" private_interface="in"/>
      <variable name="dCa_SLB_SL" units="millimolar_per_millisecond"/>
      <variable name="dCa_SLB_jct" units="millimolar_per_millisecond"/>
      <variable name="dCa_SLHigh_SL" units="millimolar_per_millisecond"/>
      <variable name="dCa_SLHigh_jct" units="millimolar_per_millisecond"/>
      <variable name="dCa_jct_tot_bound" units="millimolar_per_millisecond"/>
      <variable name="dCa_SL_tot_bound" units="millimolar_per_millisecond"/>
      <variable name="i_Ca_jct_tot" units="microA_per_microF"/>
      <variable name="i_Ca_SL_tot" units="microA_per_microF"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>dCalsequestrin</ci>
            <apply>
               <minus/>
               <apply>
                  <times/>
                  <ci>kon_Calsequestrin</ci>
                  <ci>Ca_SR</ci>
                  <apply>
                     <minus/>
                     <apply>
                        <divide/>
                        <apply>
                           <times/>
                           <ci>Bmax_Calsequestrin</ci>
                           <ci>Vol_myo</ci>
                        </apply>
                        <ci>Vol_SR</ci>
                     </apply>
                     <ci>Ca_Calsequestrin</ci>
                  </apply>
               </apply>
               <apply>
                  <times/>
                  <ci>koff_Calsequestrin</ci>
                  <ci>Ca_Calsequestrin</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>Ca_Calsequestrin</ci>
            </apply>
            <ci>dCalsequestrin</ci>
         </apply>
         <apply>
            <eq/>
            <ci>dCa_SLB_SL</ci>
            <apply>
               <minus/>
               <apply>
                  <times/>
                  <ci>kon_SL</ci>
                  <ci>Ca_SL</ci>
                  <apply>
                     <minus/>
                     <apply>
                        <divide/>
                        <apply>
                           <times/>
                           <ci>Bmax_SLB_SL</ci>
                           <ci>Vol_myo</ci>
                        </apply>
                        <ci>Vol_SL</ci>
                     </apply>
                     <ci>Ca_SLB_SL</ci>
                  </apply>
               </apply>
               <apply>
                  <times/>
                  <ci>koff_SLB</ci>
                  <ci>Ca_SLB_SL</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>dCa_SLB_jct</ci>
            <apply>
               <minus/>
               <apply>
                  <times/>
                  <ci>kon_SL</ci>
                  <ci>Ca_jct</ci>
                  <apply>
                     <minus/>
                     <apply>
                        <divide/>
                        <apply>
                           <times/>
                           <ci>Bmax_SLB_jct</ci>
                           <cn cellml:units="dimensionless">0.1</cn>
                           <ci>Vol_myo</ci>
                        </apply>
                        <ci>Vol_jct</ci>
                     </apply>
                     <ci>Ca_SLB_jct</ci>
                  </apply>
               </apply>
               <apply>
                  <times/>
                  <ci>koff_SLB</ci>
                  <ci>Ca_SLB_jct</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>dCa_SLHigh_SL</ci>
            <apply>
               <minus/>
               <apply>
                  <times/>
                  <ci>kon_SL</ci>
                  <ci>Ca_SL</ci>
                  <apply>
                     <minus/>
                     <apply>
                        <divide/>
                        <apply>
                           <times/>
                           <ci>Bmax_SLHigh_SL</ci>
                           <ci>Vol_myo</ci>
                        </apply>
                        <ci>Vol_SL</ci>
                     </apply>
                     <ci>Ca_SLHigh_SL</ci>
                  </apply>
               </apply>
               <apply>
                  <times/>
                  <ci>koff_SLHigh</ci>
                  <ci>Ca_SLHigh_SL</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>dCa_SLHigh_jct</ci>
            <apply>
               <minus/>
               <apply>
                  <times/>
                  <ci>kon_SL</ci>
                  <ci>Ca_jct</ci>
                  <apply>
                     <minus/>
                     <apply>
                        <divide/>
                        <apply>
                           <times/>
                           <ci>Bmax_SLHigh_jct</ci>
                           <cn cellml:units="dimensionless">0.1</cn>
                           <ci>Vol_myo</ci>
                        </apply>
                        <ci>Vol_jct</ci>
                     </apply>
                     <ci>Ca_SLHigh_jct</ci>
                  </apply>
               </apply>
               <apply>
                  <times/>
                  <ci>koff_SLHigh</ci>
                  <ci>Ca_SLHigh_jct</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>Ca_SLB_SL</ci>
            </apply>
            <ci>dCa_SLB_SL</ci>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>Ca_SLB_jct</ci>
            </apply>
            <ci>dCa_SLB_jct</ci>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>Ca_SLHigh_SL</ci>
            </apply>
            <ci>dCa_SLHigh_SL</ci>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>Ca_SLHigh_jct</ci>
            </apply>
            <ci>dCa_SLHigh_jct</ci>
         </apply>
         <apply>
            <eq/>
            <ci>dCa_jct_tot_bound</ci>
            <apply>
               <plus/>
               <ci>dCa_SLB_jct</ci>
               <ci>dCa_SLHigh_jct</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>dCa_SL_tot_bound</ci>
            <apply>
               <plus/>
               <ci>dCa_SLB_SL</ci>
               <ci>dCa_SLHigh_SL</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>i_Ca_jct_tot</ci>
            <apply>
               <plus/>
               <apply>
                  <minus/>
                  <ci>i_CaL_Ca_jct</ci>
                  <apply>
                     <times/>
                     <cn cellml:units="dimensionless">2</cn>
                     <ci>i_NaCa_jct</ci>
                  </apply>
               </apply>
               <ci>i_Cab_jct</ci>
               <ci>i_Cap_jct</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>i_Ca_SL_tot</ci>
            <apply>
               <plus/>
               <apply>
                  <minus/>
                  <ci>i_CaL_Ca_SL</ci>
                  <apply>
                     <times/>
                     <cn cellml:units="dimensionless">2</cn>
                     <ci>i_NaCa_SL</ci>
                  </apply>
               </apply>
               <ci>i_Cab_SL</ci>
               <ci>i_Cap_SL</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>Ca_SR</ci>
            </apply>
            <apply>
               <minus/>
               <apply>
                  <minus/>
                  <ci>j_pump_SR</ci>
                  <apply>
                     <plus/>
                     <apply>
                        <divide/>
                        <apply>
                           <times/>
                           <ci>j_leak_SR</ci>
                           <ci>Vol_myo</ci>
                        </apply>
                        <ci>Vol_SR</ci>
                     </apply>
                     <ci>j_rel_SR</ci>
                  </apply>
               </apply>
               <ci>dCalsequestrin</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>Ca_jct</ci>
            </apply>
            <apply>
               <minus/>
               <apply>
                  <plus/>
                  <apply>
                     <minus/>
                     <apply>
                        <divide/>
                        <apply>
                           <times/>
                           <apply>
                              <minus/>
                              <ci>i_Ca_jct_tot</ci>
                           </apply>
                           <ci>Cm</ci>
                        </apply>
                        <apply>
                           <times/>
                           <ci>Vol_jct</ci>
                           <cn cellml:units="dimensionless">2</cn>
                           <ci>F</ci>
                        </apply>
                     </apply>
                     <apply>
                        <divide/>
                        <ci>J_Ca_jct_SL</ci>
                        <ci>Vol_jct</ci>
                     </apply>
                  </apply>
                  <apply>
                     <divide/>
                     <apply>
                        <times/>
                        <ci>j_rel_SR</ci>
                        <ci>Vol_SR</ci>
                     </apply>
                     <ci>Vol_jct</ci>
                  </apply>
                  <apply>
                     <divide/>
                     <apply>
                        <times/>
                        <ci>j_leak_SR</ci>
                        <ci>Vol_myo</ci>
                     </apply>
                     <ci>Vol_jct</ci>
                  </apply>
               </apply>
               <apply>
                  <times/>
                  <cn cellml:units="dimensionless">1</cn>
                  <ci>dCa_jct_tot_bound</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>Ca_SL</ci>
            </apply>
            <apply>
               <minus/>
               <apply>
                  <plus/>
                  <apply>
                     <divide/>
                     <apply>
                        <times/>
                        <apply>
                           <minus/>
                           <ci>i_Ca_SL_tot</ci>
                        </apply>
                        <ci>Cm</ci>
                     </apply>
                     <apply>
                        <times/>
                        <ci>Vol_SL</ci>
                        <cn cellml:units="dimensionless">2</cn>
                        <ci>F</ci>
                     </apply>
                  </apply>
                  <apply>
                     <divide/>
                     <apply>
                        <minus/>
                        <ci>J_Ca_jct_SL</ci>
                        <ci>J_Ca_SL_myo</ci>
                     </apply>
                     <ci>Vol_SL</ci>
                  </apply>
               </apply>
               <apply>
                  <times/>
                  <cn cellml:units="dimensionless">1</cn>
                  <ci>dCa_SL_tot_bound</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>Cai</ci>
            </apply>
            <apply>
               <minus/>
               <apply>
                  <plus/>
                  <apply>
                     <divide/>
                     <apply>
                        <times/>
                        <apply>
                           <minus/>
                           <ci>j_pump_SR</ci>
                        </apply>
                        <ci>Vol_SR</ci>
                     </apply>
                     <ci>Vol_myo</ci>
                  </apply>
                  <apply>
                     <divide/>
                     <ci>J_Ca_SL_myo</ci>
                     <ci>Vol_myo</ci>
                  </apply>
               </apply>
               <apply>
                  <times/>
                  <cn cellml:units="dimensionless">1</cn>
                  <ci>dCa_cytosol_tot_bound</ci>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component xmlns="http://www.cellml.org/cellml/1.0#" name="cytosolic_Ca_buffer">
      <variable name="Cai" units="millimolar" public_interface="in"/>
      <variable name="Mgi" units="millimolar" public_interface="in"/>
      <variable name="time" units="millisecond" public_interface="in"/>
      <variable name="Ca_TroponinC" units="millimolar" initial_value="8.773191e-3" public_interface="out"/>
      <variable name="Ca_TroponinC_Ca_Mg" units="millimolar" initial_value="1.078283e-1" public_interface="out"/>
      <variable name="Mg_TroponinC_Ca_Mg" units="millimolar" initial_value="1.524002e-2" public_interface="out"/>
      <variable name="Ca_Calmodulin" units="millimolar" initial_value="2.911916e-4" public_interface="out"/>
      <variable name="Ca_Myosin" units="millimolar" initial_value="1.298754e-3" public_interface="out"/>
      <variable name="Mg_Myosin" units="millimolar" initial_value="1.381982e-1" public_interface="out"/>
      <variable name="Ca_SRB" units="millimolar" initial_value="2.143165e-3" public_interface="out"/>
      <variable name="Bmax_TroponinC" units="millimolar" initial_value="0.07"/>
      <variable name="Bmax_TroponinC_Ca_Mg_Ca" units="millimolar" initial_value="0.14"/>
      <variable name="Bmax_TroponinC_Ca_Mg_Mg" units="millimolar" initial_value="0.14"/>
      <variable name="Bmax_Calmodulin" units="millimolar" initial_value="0.024"/>
      <variable name="Bmax_Myosin_Ca" units="millimolar" initial_value="0.14"/>
      <variable name="Bmax_Myosin_Mg" units="millimolar" initial_value="0.14"/>
      <variable name="Bmax_SRB" units="millimolar" initial_value="0.0171"/>
      <variable name="kon_TroponinC" units="per_millimolar_per_millisecond" initial_value="32.7"/>
      <variable name="kon_TroponinC_Ca_Mg_Ca" units="per_millimolar_per_millisecond" initial_value="2.37"/>
      <variable name="kon_TroponinC_Ca_Mg_Mg" units="per_millimolar_per_millisecond" initial_value="3e-3"/>
      <variable name="kon_Calmodulin" units="per_millimolar_per_millisecond" initial_value="34"/>
      <variable name="kon_Myosin_Ca" units="per_millimolar_per_millisecond" initial_value="13.8"/>
      <variable name="kon_Myosin_Mg" units="per_millimolar_per_millisecond" initial_value="15.7e-3"/>
      <variable name="kon_SRB" units="per_millimolar_per_millisecond" initial_value="100"/>
      <variable name="koff_TroponinC" units="per_millisecond" initial_value="19.6e-3"/>
      <variable name="koff_TroponinC_Ca_Mg_Ca" units="per_millisecond" initial_value="0.032e-3"/>
      <variable name="koff_TroponinC_Ca_Mg_Mg" units="per_millisecond" initial_value="3.33e-3"/>
      <variable name="koff_Calmodulin" units="per_millisecond" initial_value="238e-3"/>
      <variable name="koff_Myosin_Ca" units="per_millisecond" initial_value="0.46e-3"/>
      <variable name="koff_Myosin_Mg" units="per_millisecond" initial_value="0.057e-3"/>
      <variable name="koff_SRB" units="per_millisecond" initial_value="60e-3"/>
      <variable name="dCa_TroponinC" units="millimolar_per_millisecond"/>
      <variable name="dCa_TroponinC_Ca_Mg" units="millimolar_per_millisecond"/>
      <variable name="dMg_TroponinC_Ca_Mg" units="millimolar_per_millisecond"/>
      <variable name="dCa_Calmodulin" units="millimolar_per_millisecond"/>
      <variable name="dCa_Myosin" units="millimolar_per_millisecond"/>
      <variable name="dMg_Myosin" units="millimolar_per_millisecond"/>
      <variable name="dCa_SRB" units="millimolar_per_millisecond"/>
      <variable name="dCa_cytosol_tot_bound" units="millimolar_per_millisecond" public_interface="out"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>dCa_TroponinC</ci>
            <apply>
               <minus/>
               <apply>
                  <times/>
                  <ci>kon_TroponinC</ci>
                  <ci>Cai</ci>
                  <apply>
                     <minus/>
                     <ci>Bmax_TroponinC</ci>
                     <ci>Ca_TroponinC</ci>
                  </apply>
               </apply>
               <apply>
                  <times/>
                  <ci>koff_TroponinC</ci>
                  <ci>Ca_TroponinC</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>dCa_TroponinC_Ca_Mg</ci>
            <apply>
               <minus/>
               <apply>
                  <times/>
                  <ci>kon_TroponinC_Ca_Mg_Ca</ci>
                  <ci>Cai</ci>
                  <apply>
                     <minus/>
                     <ci>Bmax_TroponinC_Ca_Mg_Ca</ci>
                     <apply>
                        <plus/>
                        <ci>Ca_TroponinC_Ca_Mg</ci>
                        <ci>Mg_TroponinC_Ca_Mg</ci>
                     </apply>
                  </apply>
               </apply>
               <apply>
                  <times/>
                  <ci>koff_TroponinC_Ca_Mg_Ca</ci>
                  <ci>Ca_TroponinC_Ca_Mg</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>dMg_TroponinC_Ca_Mg</ci>
            <apply>
               <minus/>
               <apply>
                  <times/>
                  <ci>kon_TroponinC_Ca_Mg_Mg</ci>
                  <ci>Mgi</ci>
                  <apply>
                     <minus/>
                     <ci>Bmax_TroponinC_Ca_Mg_Mg</ci>
                     <apply>
                        <plus/>
                        <ci>Ca_TroponinC_Ca_Mg</ci>
                        <ci>Mg_TroponinC_Ca_Mg</ci>
                     </apply>
                  </apply>
               </apply>
               <apply>
                  <times/>
                  <ci>koff_TroponinC_Ca_Mg_Mg</ci>
                  <ci>Mg_TroponinC_Ca_Mg</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>dCa_Calmodulin</ci>
            <apply>
               <minus/>
               <apply>
                  <times/>
                  <ci>kon_Calmodulin</ci>
                  <ci>Cai</ci>
                  <apply>
                     <minus/>
                     <ci>Bmax_Calmodulin</ci>
                     <ci>Ca_Calmodulin</ci>
                  </apply>
               </apply>
               <apply>
                  <times/>
                  <ci>koff_Calmodulin</ci>
                  <ci>Ca_Calmodulin</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>dCa_Myosin</ci>
            <apply>
               <minus/>
               <apply>
                  <times/>
                  <ci>kon_Myosin_Ca</ci>
                  <ci>Cai</ci>
                  <apply>
                     <minus/>
                     <ci>Bmax_Myosin_Ca</ci>
                     <apply>
                        <plus/>
                        <ci>Ca_Myosin</ci>
                        <ci>Mg_Myosin</ci>
                     </apply>
                  </apply>
               </apply>
               <apply>
                  <times/>
                  <ci>koff_Myosin_Ca</ci>
                  <ci>Ca_Myosin</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>dMg_Myosin</ci>
            <apply>
               <minus/>
               <apply>
                  <times/>
                  <ci>kon_Myosin_Mg</ci>
                  <ci>Mgi</ci>
                  <apply>
                     <minus/>
                     <ci>Bmax_Myosin_Mg</ci>
                     <apply>
                        <plus/>
                        <ci>Ca_Myosin</ci>
                        <ci>Mg_Myosin</ci>
                     </apply>
                  </apply>
               </apply>
               <apply>
                  <times/>
                  <ci>koff_Myosin_Mg</ci>
                  <ci>Mg_Myosin</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>dCa_SRB</ci>
            <apply>
               <minus/>
               <apply>
                  <times/>
                  <ci>kon_SRB</ci>
                  <ci>Cai</ci>
                  <apply>
                     <minus/>
                     <ci>Bmax_SRB</ci>
                     <ci>Ca_SRB</ci>
                  </apply>
               </apply>
               <apply>
                  <times/>
                  <ci>koff_SRB</ci>
                  <ci>Ca_SRB</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>dCa_cytosol_tot_bound</ci>
            <apply>
               <plus/>
               <ci>dCa_TroponinC</ci>
               <ci>dCa_TroponinC_Ca_Mg</ci>
               <ci>dMg_TroponinC_Ca_Mg</ci>
               <ci>dCa_Calmodulin</ci>
               <ci>dCa_Myosin</ci>
               <ci>dMg_Myosin</ci>
               <ci>dCa_SRB</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>Ca_TroponinC</ci>
            </apply>
            <ci>dCa_TroponinC</ci>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>Ca_TroponinC_Ca_Mg</ci>
            </apply>
            <ci>dCa_TroponinC_Ca_Mg</ci>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>Mg_TroponinC_Ca_Mg</ci>
            </apply>
            <ci>dMg_TroponinC_Ca_Mg</ci>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>Ca_Calmodulin</ci>
            </apply>
            <ci>dCa_Calmodulin</ci>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>Ca_Myosin</ci>
            </apply>
            <ci>dCa_Myosin</ci>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>Mg_Myosin</ci>
            </apply>
            <ci>dMg_Myosin</ci>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>Ca_SRB</ci>
            </apply>
            <ci>dCa_SRB</ci>
         </apply>
      </math>
   </component>
   <component xmlns="http://www.cellml.org/cellml/1.0#" name="Ions_n_reversal_potentials"/>
   <component xmlns="http://www.cellml.org/cellml/1.0#" name="transmembrane_currents"/>
   <component xmlns="http://www.cellml.org/cellml/1.0#" name="intracellular_currents"/>
   <group xmlns="http://www.cellml.org/cellml/1.0#">
      <relationship_ref relationship="containment"/>
      <component_ref component="cell">
         <component_ref component="transmembrane_currents">
            <component_ref component="INa">
               <component_ref component="INa_m_gate"/>
               <component_ref component="INa_h_gate"/>
               <component_ref component="INa_j_gate"/>
            </component_ref>
            <component_ref component="ICaL">
               <component_ref component="ICaL_d_gate"/>
               <component_ref component="ICaL_f_gate"/>
               <component_ref component="ICaL_fCa_gate"/>
            </component_ref>
            <component_ref component="ICap"/>
            <component_ref component="ICab"/>
            <component_ref component="IKs">
               <component_ref component="IKs_Xs_gate"/>
            </component_ref>
            <component_ref component="IKr">
               <component_ref component="IKr_Xr_gate"/>
               <component_ref component="IKr_Rr_gate"/>
            </component_ref>
            <component_ref component="Itof">
               <component_ref component="Itof_X_gate"/>
               <component_ref component="Itof_Y_gate"/>
            </component_ref>
            <component_ref component="Itos">
               <component_ref component="Itos_X_gate"/>
               <component_ref component="Itos_Y_gate"/>
               <component_ref component="Itos_R_gate"/>
            </component_ref>
            <component_ref component="IK1">
               <component_ref component="IK1_K1_gate"/>
            </component_ref>
            <component_ref component="ICl_Ca"/>
            <component_ref component="IClb"/>
            <component_ref component="INaCa"/>
            <component_ref component="INab"/>
            <component_ref component="INaK"/>
         </component_ref>
         <component_ref component="Ions_n_reversal_potentials">
            <component_ref component="Ca_buffer">
               <component_ref component="cytosolic_Ca_buffer"/>
            </component_ref>
            <component_ref component="reversal_potentials"/>
            <component_ref component="ion_diffusion"/>
            <component_ref component="Na_buffer"/>
         </component_ref>
         <component_ref component="intracellular_currents">
            <component_ref component="Jpump_SR"/>
            <component_ref component="Jrel_SR"/>
            <component_ref component="Jleak_SR"/>
         </component_ref>
      </component_ref>
   </group>
   <group xmlns="http://www.cellml.org/cellml/1.0#">
      <relationship_ref relationship="encapsulation"/>
      <component_ref component="INa">
         <component_ref component="INa_m_gate"/>
         <component_ref component="INa_h_gate"/>
         <component_ref component="INa_j_gate"/>
      </component_ref>
      <component_ref component="ICaL">
         <component_ref component="ICaL_d_gate"/>
         <component_ref component="ICaL_f_gate"/>
         <component_ref component="ICaL_fCa_gate"/>
      </component_ref>
      <component_ref component="IKs">
         <component_ref component="IKs_Xs_gate"/>
      </component_ref>
      <component_ref component="IKr">
         <component_ref component="IKr_Xr_gate"/>
         <component_ref component="IKr_Rr_gate"/>
      </component_ref>
      <component_ref component="Itof">
         <component_ref component="Itof_X_gate"/>
         <component_ref component="Itof_Y_gate"/>
      </component_ref>
      <component_ref component="Itos">
         <component_ref component="Itos_X_gate"/>
         <component_ref component="Itos_Y_gate"/>
         <component_ref component="Itos_R_gate"/>
      </component_ref>
      <component_ref component="IK1">
         <component_ref component="IK1_K1_gate"/>
      </component_ref>
      <component_ref component="Ca_buffer">
         <component_ref component="cytosolic_Ca_buffer"/>
      </component_ref>
   </group>
   <connection xmlns="http://www.cellml.org/cellml/1.0#">
      <map_components component_1="cell" component_2="environment"/>
      <map_variables variable_1="time" variable_2="time"/>
   </connection>
   <connection xmlns="http://www.cellml.org/cellml/1.0#">
      <map_components component_1="Na_buffer" component_2="environment"/>
      <map_variables variable_1="time" variable_2="time"/>
   </connection>
   <connection xmlns="http://www.cellml.org/cellml/1.0#">
      <map_components component_1="INa" component_2="environment"/>
      <map_variables variable_1="time" variable_2="time"/>
   </connection>
   <connection xmlns="http://www.cellml.org/cellml/1.0#">
      <map_components component_1="Itos" component_2="environment"/>
      <map_variables variable_1="time" variable_2="time"/>
   </connection>
   <connection xmlns="http://www.cellml.org/cellml/1.0#">
      <map_components component_1="Itof" component_2="environment"/>
      <map_variables variable_1="time" variable_2="time"/>
   </connection>
   <connection xmlns="http://www.cellml.org/cellml/1.0#">
      <map_components component_1="IKs" component_2="environment"/>
      <map_variables variable_1="time" variable_2="time"/>
   </connection>
   <connection xmlns="http://www.cellml.org/cellml/1.0#">
      <map_components component_1="IKr" component_2="environment"/>
      <map_variables variable_1="time" variable_2="time"/>
   </connection>
   <connection xmlns="http://www.cellml.org/cellml/1.0#">
      <map_components component_1="Jrel_SR" component_2="environment"/>
      <map_variables variable_1="time" variable_2="time"/>
   </connection>
   <connection xmlns="http://www.cellml.org/cellml/1.0#">
      <map_components component_1="Ca_buffer" component_2="environment"/>
      <map_variables variable_1="time" variable_2="time"/>
   </connection>
   <connection xmlns="http://www.cellml.org/cellml/1.0#">
      <map_components component_1="ICaL" component_2="environment"/>
      <map_variables variable_1="time" variable_2="time"/>
   </connection>
   <connection xmlns="http://www.cellml.org/cellml/1.0#">
      <map_components component_1="cell" component_2="INa"/>
      <map_variables variable_1="V" variable_2="V"/>
      <map_variables variable_1="i_Na" variable_2="i_Na"/>
   </connection>
   <connection xmlns="http://www.cellml.org/cellml/1.0#">
      <map_components component_1="cell" component_2="ICaL"/>
      <map_variables variable_1="V" variable_2="V"/>
      <map_variables variable_1="i_CaL" variable_2="i_CaL"/>
   </connection>
   <connection xmlns="http://www.cellml.org/cellml/1.0#">
      <map_components component_1="cell" component_2="IKp"/>
      <map_variables variable_1="V" variable_2="V"/>
      <map_variables variable_1="i_Kp" variable_2="i_Kp"/>
   </connection>
   <connection xmlns="http://www.cellml.org/cellml/1.0#">
      <map_components component_1="cell" component_2="Itos"/>
      <map_variables variable_1="V" variable_2="V"/>
      <map_variables variable_1="i_tos" variable_2="i_tos"/>
   </connection>
   <connection xmlns="http://www.cellml.org/cellml/1.0#">
      <map_components component_1="cell" component_2="Itof"/>
      <map_variables variable_1="V" variable_2="V"/>
      <map_variables variable_1="i_tof" variable_2="i_tof"/>
   </connection>
   <connection xmlns="http://www.cellml.org/cellml/1.0#">
      <map_components component_1="cell" component_2="IKs"/>
      <map_variables variable_1="V" variable_2="V"/>
      <map_variables variable_1="i_Ks" variable_2="i_Ks"/>
   </connection>
   <connection xmlns="http://www.cellml.org/cellml/1.0#">
      <map_components component_1="cell" component_2="IKr"/>
      <map_variables variable_1="V" variable_2="V"/>
      <map_variables variable_1="i_Kr" variable_2="i_Kr"/>
   </connection>
   <connection xmlns="http://www.cellml.org/cellml/1.0#">
      <map_components component_1="cell" component_2="IK1"/>
      <map_variables variable_1="V" variable_2="V"/>
      <map_variables variable_1="i_K1" variable_2="i_K1"/>
   </connection>
   <connection xmlns="http://www.cellml.org/cellml/1.0#">
      <map_components component_1="cell" component_2="INaCa"/>
      <map_variables variable_1="V" variable_2="V"/>
      <map_variables variable_1="i_NaCa" variable_2="i_NaCa"/>
   </connection>
   <connection xmlns="http://www.cellml.org/cellml/1.0#">
      <map_components component_1="cell" component_2="INaK"/>
      <map_variables variable_1="V" variable_2="V"/>
      <map_variables variable_1="i_NaK" variable_2="i_NaK"/>
   </connection>
   <connection xmlns="http://www.cellml.org/cellml/1.0#">
      <map_components component_1="cell" component_2="INab"/>
      <map_variables variable_1="V" variable_2="V"/>
      <map_variables variable_1="i_Nab" variable_2="i_Nab"/>
   </connection>
   <connection xmlns="http://www.cellml.org/cellml/1.0#">
      <map_components component_1="cell" component_2="ICab"/>
      <map_variables variable_1="V" variable_2="V"/>
      <map_variables variable_1="i_Cab" variable_2="i_Cab"/>
   </connection>
   <connection xmlns="http://www.cellml.org/cellml/1.0#">
      <map_components component_1="cell" component_2="ICl_Ca"/>
      <map_variables variable_1="V" variable_2="V"/>
      <map_variables variable_1="i_Cl_Ca" variable_2="i_Cl_Ca"/>
   </connection>
   <connection xmlns="http://www.cellml.org/cellml/1.0#">
      <map_components component_1="cell" component_2="IClb"/>
      <map_variables variable_1="V" variable_2="V"/>
      <map_variables variable_1="i_Clb" variable_2="i_Clb"/>
   </connection>
   <connection xmlns="http://www.cellml.org/cellml/1.0#">
      <map_components component_1="cell" component_2="ICap"/>
      <map_variables variable_1="i_Cap" variable_2="i_Cap"/>
   </connection>
   <connection xmlns="http://www.cellml.org/cellml/1.0#">
      <map_components component_1="reversal_potentials" component_2="INa"/>
      <map_variables variable_1="E_Na_jct" variable_2="E_Na_jct"/>
      <map_variables variable_1="E_Na_SL" variable_2="E_Na_SL"/>
   </connection>
   <connection xmlns="http://www.cellml.org/cellml/1.0#">
      <map_components component_1="reversal_potentials" component_2="IKp"/>
      <map_variables variable_1="E_K" variable_2="E_K"/>
   </connection>
   <connection xmlns="http://www.cellml.org/cellml/1.0#">
      <map_components component_1="reversal_potentials" component_2="Itos"/>
      <map_variables variable_1="E_K" variable_2="E_K"/>
   </connection>
   <connection xmlns="http://www.cellml.org/cellml/1.0#">
      <map_components component_1="reversal_potentials" component_2="Itof"/>
      <map_variables variable_1="E_K" variable_2="E_K"/>
   </connection>
   <connection xmlns="http://www.cellml.org/cellml/1.0#">
      <map_components component_1="reversal_potentials" component_2="IKr"/>
      <map_variables variable_1="E_K" variable_2="E_K"/>
   </connection>
   <connection xmlns="http://www.cellml.org/cellml/1.0#">
      <map_components component_1="reversal_potentials" component_2="IK1"/>
      <map_variables variable_1="E_K" variable_2="E_K"/>
   </connection>
   <connection xmlns="http://www.cellml.org/cellml/1.0#">
      <map_components component_1="reversal_potentials" component_2="INab"/>
      <map_variables variable_1="E_Na_jct" variable_2="E_Na_jct"/>
      <map_variables variable_1="E_Na_SL" variable_2="E_Na_SL"/>
   </connection>
   <connection xmlns="http://www.cellml.org/cellml/1.0#">
      <map_components component_1="reversal_potentials" component_2="ICab"/>
      <map_variables variable_1="E_Ca_SL" variable_2="E_Ca_SL"/>
      <map_variables variable_1="E_Ca_jct" variable_2="E_Ca_jct"/>
   </connection>
   <connection xmlns="http://www.cellml.org/cellml/1.0#">
      <map_components component_1="reversal_potentials" component_2="ICl_Ca"/>
      <map_variables variable_1="E_Cl" variable_2="E_Cl"/>
   </connection>
   <connection xmlns="http://www.cellml.org/cellml/1.0#">
      <map_components component_1="reversal_potentials" component_2="IClb"/>
      <map_variables variable_1="E_Cl" variable_2="E_Cl"/>
   </connection>
   <connection xmlns="http://www.cellml.org/cellml/1.0#">
      <map_components component_1="reversal_potentials" component_2="Na_buffer"/>
      <map_variables variable_1="Nai" variable_2="Nai"/>
      <map_variables variable_1="Na_jct" variable_2="Na_jct"/>
      <map_variables variable_1="Na_SL" variable_2="Na_SL"/>
   </connection>
   <connection xmlns="http://www.cellml.org/cellml/1.0#">
      <map_components component_1="reversal_potentials" component_2="Ca_buffer"/>
      <map_variables variable_1="Cai" variable_2="Cai"/>
      <map_variables variable_1="Ca_jct" variable_2="Ca_jct"/>
      <map_variables variable_1="Ca_SL" variable_2="Ca_SL"/>
   </connection>
   <connection xmlns="http://www.cellml.org/cellml/1.0#">
      <map_components component_1="reversal_potentials" component_2="model_parameters"/>
      <map_variables variable_1="Ki" variable_2="Ki"/>
      <map_variables variable_1="Cli" variable_2="Cli"/>
      <map_variables variable_1="Clo" variable_2="Clo"/>
      <map_variables variable_1="Nao" variable_2="Nao"/>
      <map_variables variable_1="Cao" variable_2="Cao"/>
      <map_variables variable_1="Ko" variable_2="Ko"/>
      <map_variables variable_1="R" variable_2="R"/>
      <map_variables variable_1="T" variable_2="T"/>
      <map_variables variable_1="F" variable_2="F"/>
   </connection>
   <connection xmlns="http://www.cellml.org/cellml/1.0#">
      <map_components component_1="model_parameters" component_2="Ca_buffer"/>
      <map_variables variable_1="Mgi" variable_2="Mgi"/>
      <map_variables variable_1="Vol_SR" variable_2="Vol_SR"/>
      <map_variables variable_1="Vol_SL" variable_2="Vol_SL"/>
      <map_variables variable_1="Vol_jct" variable_2="Vol_jct"/>
      <map_variables variable_1="Vol_myo" variable_2="Vol_myo"/>
      <map_variables variable_1="F" variable_2="F"/>
      <map_variables variable_1="Cm" variable_2="Cm"/>
   </connection>
   <connection xmlns="http://www.cellml.org/cellml/1.0#">
      <map_components component_1="model_parameters" component_2="ICaL"/>
      <map_variables variable_1="R" variable_2="R"/>
      <map_variables variable_1="T" variable_2="T"/>
      <map_variables variable_1="F" variable_2="F"/>
      <map_variables variable_1="Cao" variable_2="Cao"/>
      <map_variables variable_1="Nao" variable_2="Nao"/>
      <map_variables variable_1="Ko" variable_2="Ko"/>
      <map_variables variable_1="Ki" variable_2="Ki"/>
   </connection>
   <connection xmlns="http://www.cellml.org/cellml/1.0#">
      <map_components component_1="model_parameters" component_2="INaCa"/>
      <map_variables variable_1="Nao" variable_2="Nao"/>
      <map_variables variable_1="R" variable_2="R"/>
      <map_variables variable_1="T" variable_2="T"/>
      <map_variables variable_1="F" variable_2="F"/>
      <map_variables variable_1="Cao" variable_2="Cao"/>
   </connection>
   <connection xmlns="http://www.cellml.org/cellml/1.0#">
      <map_components component_1="model_parameters" component_2="INaK"/>
      <map_variables variable_1="Ko" variable_2="Ko"/>
      <map_variables variable_1="Nao" variable_2="Nao"/>
      <map_variables variable_1="R" variable_2="R"/>
      <map_variables variable_1="T" variable_2="T"/>
      <map_variables variable_1="F" variable_2="F"/>
   </connection>
   <connection xmlns="http://www.cellml.org/cellml/1.0#">
      <map_components component_1="model_parameters" component_2="IKr"/>
      <map_variables variable_1="Ko" variable_2="Ko"/>
   </connection>
   <connection xmlns="http://www.cellml.org/cellml/1.0#">
      <map_components component_1="model_parameters" component_2="IKs"/>
      <map_variables variable_1="Ko" variable_2="Ko"/>
      <map_variables variable_1="Ki" variable_2="Ki"/>
      <map_variables variable_1="Nao" variable_2="Nao"/>
      <map_variables variable_1="R" variable_2="R"/>
      <map_variables variable_1="T" variable_2="T"/>
      <map_variables variable_1="F" variable_2="F"/>
   </connection>
   <connection xmlns="http://www.cellml.org/cellml/1.0#">
      <map_components component_1="model_parameters" component_2="IK1"/>
      <map_variables variable_1="Ko" variable_2="Ko"/>
   </connection>
   <connection xmlns="http://www.cellml.org/cellml/1.0#">
      <map_components component_1="model_parameters" component_2="ICap"/>
      <map_variables variable_1="T" variable_2="T"/>
      <map_variables variable_1="Vol_myo" variable_2="Vol_myo"/>
      <map_variables variable_1="F" variable_2="F"/>
      <map_variables variable_1="Cm" variable_2="Cm"/>
   </connection>
   <connection xmlns="http://www.cellml.org/cellml/1.0#">
      <map_components component_1="model_parameters" component_2="Jpump_SR"/>
      <map_variables variable_1="T" variable_2="T"/>
      <map_variables variable_1="Vol_myo" variable_2="Vol_myo"/>
   </connection>
   <connection xmlns="http://www.cellml.org/cellml/1.0#">
      <map_components component_1="model_parameters" component_2="Na_buffer"/>
      <map_variables variable_1="Vol_SR" variable_2="Vol_SR"/>
      <map_variables variable_1="Vol_SL" variable_2="Vol_SL"/>
      <map_variables variable_1="Vol_jct" variable_2="Vol_jct"/>
      <map_variables variable_1="Vol_myo" variable_2="Vol_myo"/>
      <map_variables variable_1="F" variable_2="F"/>
      <map_variables variable_1="Cm" variable_2="Cm"/>
   </connection>
   <connection xmlns="http://www.cellml.org/cellml/1.0#">
      <map_components component_1="INa" component_2="INa_m_gate"/>
      <map_variables variable_1="m" variable_2="m"/>
      <map_variables variable_1="time" variable_2="time"/>
      <map_variables variable_1="V" variable_2="V"/>
   </connection>
   <connection xmlns="http://www.cellml.org/cellml/1.0#">
      <map_components component_1="INa" component_2="INa_h_gate"/>
      <map_variables variable_1="h" variable_2="h"/>
      <map_variables variable_1="time" variable_2="time"/>
      <map_variables variable_1="V" variable_2="V"/>
   </connection>
   <connection xmlns="http://www.cellml.org/cellml/1.0#">
      <map_components component_1="INa" component_2="INa_j_gate"/>
      <map_variables variable_1="j" variable_2="j"/>
      <map_variables variable_1="time" variable_2="time"/>
      <map_variables variable_1="V" variable_2="V"/>
   </connection>
   <connection xmlns="http://www.cellml.org/cellml/1.0#">
      <map_components component_1="ICaL" component_2="ICaL_d_gate"/>
      <map_variables variable_1="d" variable_2="d"/>
      <map_variables variable_1="time" variable_2="time"/>
      <map_variables variable_1="V" variable_2="V"/>
   </connection>
   <connection xmlns="http://www.cellml.org/cellml/1.0#">
      <map_components component_1="ICaL" component_2="ICaL_f_gate"/>
      <map_variables variable_1="f" variable_2="f"/>
      <map_variables variable_1="time" variable_2="time"/>
      <map_variables variable_1="V" variable_2="V"/>
   </connection>
   <connection xmlns="http://www.cellml.org/cellml/1.0#">
      <map_components component_1="ICaL" component_2="ICaL_fCa_gate"/>
      <map_variables variable_1="fCa_SL" variable_2="fCa_SL"/>
      <map_variables variable_1="fCa_jct" variable_2="fCa_jct"/>
      <map_variables variable_1="time" variable_2="time"/>
      <map_variables variable_1="Ca_SL" variable_2="Ca_SL"/>
      <map_variables variable_1="Ca_jct" variable_2="Ca_jct"/>
   </connection>
   <connection xmlns="http://www.cellml.org/cellml/1.0#">
      <map_components component_1="Itos" component_2="Itos_X_gate"/>
      <map_variables variable_1="X_tos" variable_2="X_tos"/>
      <map_variables variable_1="time" variable_2="time"/>
      <map_variables variable_1="V" variable_2="V"/>
   </connection>
   <connection xmlns="http://www.cellml.org/cellml/1.0#">
      <map_components component_1="Itos" component_2="Itos_Y_gate"/>
      <map_variables variable_1="Y_tos" variable_2="Y_tos"/>
      <map_variables variable_1="time" variable_2="time"/>
      <map_variables variable_1="V" variable_2="V"/>
   </connection>
   <connection xmlns="http://www.cellml.org/cellml/1.0#">
      <map_components component_1="Itos" component_2="Itos_R_gate"/>
      <map_variables variable_1="R_tos" variable_2="R_tos"/>
      <map_variables variable_1="time" variable_2="time"/>
      <map_variables variable_1="V" variable_2="V"/>
   </connection>
   <connection xmlns="http://www.cellml.org/cellml/1.0#">
      <map_components component_1="Itof" component_2="Itof_X_gate"/>
      <map_variables variable_1="X_tof" variable_2="X_tof"/>
      <map_variables variable_1="time" variable_2="time"/>
      <map_variables variable_1="V" variable_2="V"/>
   </connection>
   <connection xmlns="http://www.cellml.org/cellml/1.0#">
      <map_components component_1="Itof" component_2="Itof_Y_gate"/>
      <map_variables variable_1="Y_tof" variable_2="Y_tof"/>
      <map_variables variable_1="time" variable_2="time"/>
      <map_variables variable_1="V" variable_2="V"/>
   </connection>
   <connection xmlns="http://www.cellml.org/cellml/1.0#">
      <map_components component_1="IKs" component_2="IKs_Xs_gate"/>
      <map_variables variable_1="Xs" variable_2="Xs"/>
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