Revised formulation of the Hodgkin-Huxley representation of the sodium current in cardiac cells

Model Status

This is the original unchecked version of the model imported from the previous CellML model repository, 24-Jan-2006.

Model Structure

In 1987, Jean-Pierre Drouhard and Fernand A. Roberge published a revised formulation of the Hodgkin-Huxley representation of the sodium current in ventricular myocardial cells. Their improvements have ensured that the action potential upstroke is much faster, and in agreement with experimental observations the peak depolarisation is close to the sodium potential. Like the Ebihara-Johnson model (1980), the Drouhard-Roberge model can be used to replace the sodium kinetics of the Beeler-Reuter model (1977).

The complete original paper reference is cited below:

Revised Formulation of the Hodgkin-Huxley Representation of the Sodium Current in Cardiac Cells, Jean-Pierre Drouhard and Fernand A. Roberge, 1987, Computers and Biomedical Research , 20, 333-350. PubMed ID: 3621918

The raw CellML description of the Drouhard-Roberge model can be downloaded in various formats as described in . For an example of a more complete documentation for an electrophysiological model, see The Hodgkin-Huxley Squid Axon Model, 1952.