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Component: environment

Component: Calcium

Component: undefinedvariables

Component: DGBM_Model_Modules

\frac{d}{d t} (Ga_GDP) = (Ga_GTP kfD7 - (Ga_GDP kfD8 Gbg)) + CaGqPLC kfG5 \frac{d}{d t} (mGluR) = (kfD5 Gabg_GluR - (kbD5 Gabg mGluR) - (kfD3 mGluR - (kbD3 Glu R))) + kfD6 Gabg_GluR \frac{d}{d t} (Gabg) = (Ga_GDP Gbg kfD8 - (Gabg R kfD4 - (Gabg_R kbD4))) + kfD5 Gabg_GluR - (kbD5 Gabg mGluR) - (kfD9 Gabg GTP) \frac{d}{d t} (R) = kfD3 mGluR - (kbD3 Glu R) - (Gabg R kfD4 - (Gabg_R kbD4)) \frac{d}{d t} (Gbg) = (- Ga_GDP) Gbg kfD8 + kfD6 Gabg_GluR + kfD9 Gabg GTP - (kfB8 GEF Gbg - (kbB8 Gbg_GEF)) \frac{d}{d t} (Gabg_R) = (Gabg R kfD4 - (Gabg_R kbD4)) + kfD2 Gabg_GluR - (Gabg_R Glu kbD2) \frac{d}{d t} (Glu_synapse) = - (kfD1 Glu_synapse - (kbD1 Glu)) \frac{d}{d t} (Gabg_GluR) = - (kfD2 Gabg_GluR - (Gabg_R Glu kbD2)) - (kfD5 Gabg_GluR - (kbD5 Gabg mGluR)) - (kfD6 Gabg_GluR) \frac{d}{d t} (Glu) = ((kfD1 Glu_synapse - (kbD1 Glu)) + kfD2 Gabg_GluR - (Gabg_R Glu kbD2)) + kfD3 mGluR - (kbD3 Glu R) \frac{d}{d t} (Ga_GTP) = kfD9 Gabg GTP - (Ga_GTP kfD7) - (PLC Ga_GTP kfG2 - (GqPLC kbG2)) - (CaGqPLC kbG4 + CaPLC Ga_GTP kfG4) \frac{d}{d t} (PLC) = - (PLC Ca kfG1 - (CaPLC kbG1)) - (PLC Ga_GTP kfG2 - (GqPLC kbG2)) \frac{d}{d t} (GqPLC) = PLC Ga_GTP kfG2 - (GqPLC kbG2) - (Ca GqPLC kfG3 - (CaGqPLC kbG3)) \frac{d}{d t} (CaPLC) = (PLC Ca kfG1 - (CaPLC kbG1)) + CaGqPLC kfG5 - ((- CaGqPLC) kbG4 + CaPLC Ga_GTP kfG4) \frac{d}{d t} (CaGqPLC) = (GqPLC Ca kfG3 - (CaGqPLC kbG3)) + CaPLC Ga_GTP kfG4 - (CaGqPLC kbG4) - (CaGqPLC kfG5) \frac{d}{d t} (GEF_inact) = \frac{PKA VmaxB1 GEF}{kmB1 + GEF} - (kfB2 GEF_inact) \frac{d}{d t} (GEF) = ((- (\frac{PKA VmaxB1 GEF}{kmB1 + GEF} + \frac{PKC VmaxB6 GEF}{kmB6 (one + \frac{GAP}{kmB3} + \frac{Ng}{kmM7} + \frac{Raf}{kmH1} + \frac{NgCaM}{kmM8}) + GEF} - (kfB2 GEF_inact) - (kfB7 GEF_star)) - (kfB5 Ca4CAM GEF)) + kbB5 CaM_GEF - (kfB8 GEF Gbg)) + kbB8 Gbg_GEF \frac{d}{d t} (CaM_GEF) = (- kbB5) CaM_GEF + kfB5 GEF Ca4CAM \frac{d}{d t} (Ca4CAM) = (- ((- kbB5) CaM_GEF + kfB5 GEF Ca4CAM)) + Ca Ca3CaM kfM3 - (kbM3 Ca4CAM) \frac{d}{d t} (Gbg_GEF) = - ((- kfB8) GEF Gbg + kbB8 Gbg_GEF) \frac{d}{d t} (GEF_star) = \frac{PKC VmaxB6 GEF}{kmB6 (one + \frac{GAP}{kmB3} + \frac{Ng}{kmM7} + \frac{Raf}{kmH1} + \frac{NgCaM}{kmM8}) + GEF} - (kfB7 GEF_star) \frac{d}{d t} (CaM) = (- (kfM1 Ca Ca CaM - (kbM1 Ca2CaM)) - (kfM4 Ng CaM - (kbM4 NgCaM))) + \frac{NgCaM PKC VmaxM8}{NgCaM + kmM8} \frac{d}{d t} (NgCaM) = kfM4 Ng CaM - (kbM4 NgCaM) - (\frac{NgCaM PKC VmaxM8}{NgCaM + kmM8 (one + \frac{GAP}{kmB3} + \frac{GEF}{kmB6} + \frac{Raf}{kmH1} + \frac{Ng}{kmM7})}) \frac{d}{d t} (Ca2CaM) = kfM1 Ca Ca CaM - (kbM1 Ca2CaM) - (Ca Ca2CaM kfM2 - (kbM2 Ca3CaM)) \frac{d}{d t} (Ca3CaM) = Ca Ca2CaM kfM2 - (kbM2 Ca3CaM) - (Ca Ca3CaM kfM3 - (kbM3 Ca4CAM)) \frac{d}{d t} (Ng_star) = (\frac{NgCaM PKC VmaxM8}{NgCaM + kmM8 (one + \frac{GAP}{kmB3} + \frac{GEF}{kmB6} + \frac{Raf}{kmH1} + \frac{Ng}{kmM7})} - (kfM6 Ng_star) - (\frac{VmaxM5 Ng_star}{Ng_star + kmM5})) + \frac{Ng PKC VmaxM7}{Ng + kmM7 (one + \frac{GAP}{kmB3} + \frac{GEF}{kmB6} + \frac{Raf}{kmH1} + \frac{NgCaM}{kmM8})} \frac{d}{d t} (Ng) = kfM6 Ng_star + \frac{VmaxM5 Ng_star}{Ng_star + kmM5} - (\frac{Ng PKC VmaxM7}{Ng + kmM7 (one + \frac{GAP}{kmB3} + \frac{GEF}{kmB6} + \frac{Raf}{kmH1} + \frac{NgCaM}{kmM8})})

Component: B_Model_Modules

\frac{d}{d t} (GTP_RAS) = ((\frac{(- GAP) VmaxB13 GTP_RAS}{kmB13 + GTP_RAS} - (kfB12 GTP_RAS)) + \frac{GEF_star VmaxB10 GDP_RAS}{kmB10 + GDP_RAS} + \frac{Gbg_GEF VmaxB11 GDP_RAS}{kmB11 + GDP_RAS} + \frac{CaM_GEF VmaxB9 GDP_RAS}{kmB9 + GDP_RAS} + \frac{SHCstar_SOS_GRB2 VmaxA7 GDP_RAS}{kmA7 + GDP_RAS} - (GTP_RAS Raf_star kfH5)) + GTPRasRaf_star kbH5 \frac{d}{d t} (GDP_RAS) = - ((\frac{(- GAP) VmaxB13 GTP_RAS}{kmB13 + GTP_RAS} - (kfB12 GTP_RAS)) + \frac{GEF_star VmaxB10 GDP_RAS}{kmB10 + GDP_RAS} + \frac{Gbg_GEF VmaxB11 GDP_RAS}{kmB11 + GDP_RAS} + \frac{CaM_GEF VmaxB9 GDP_RAS}{kmB9 + GDP_RAS}) - (\frac{SHCstar_SOS_GRB2 VmaxA7 GDP_RAS}{kmA7 + GDP_RAS}) \frac{d}{d t} (GAP) = \frac{(- PKC) VmaxB3 GAP}{kmB3 (one + \frac{Raf}{kmH1} + \frac{GEF}{kmB6} + \frac{Ng}{kmM7} + \frac{NgCaM}{kmM8}) + GAP} + kfB4 GAPstar \frac{d}{d t} (GAPstar) = \frac{PKC VmaxB3 GAP}{kmB3 (one + \frac{Raf}{kmH1} + \frac{GEF}{kmB6} + \frac{Ng}{kmM7} + \frac{NgCaM}{kmM8}) + GAP} - (kfB4 GAPstar) \frac{d}{d t} (GTPRasRaf_star) = GTP_RAS Raf_star kfH5 - (GTPRasRaf_star kbH5) \frac{d}{d t} (Raf) = \frac{(- PKC) Raf VmaxH1}{kmH1 (one + \frac{GAP}{kmB3} + \frac{GEF}{kmB6} + \frac{Ng}{kmM7} + \frac{NgCaM}{kmM8}) + Raf} + \frac{Raf_star PP2A VmaxH3}{kmH3 (one + \frac{Raf_star_star}{kmH4} + \frac{MAPKK_star_star}{kmH9} + \frac{MAPKK_star}{kmH8}) + Raf_star} \frac{d}{d t} (Raf_star) = (\frac{PKC Raf VmaxH1}{kmH1 (one + \frac{GAP}{kmB3} + \frac{GEF}{kmB6} + \frac{Ng}{kmM7} + \frac{NgCaM}{kmM8}) + Raf} - (\frac{Raf_star PP2A VmaxH3}{kmH3 (one + \frac{Raf_star_star}{kmH4} + \frac{MAPKK_star_star}{kmH9} + \frac{MAPKK_star}{kmH8}) + Raf_star}) - (\frac{Raf_star MAPK_star VmaxH2}{kmH2 (one + \frac{SOS}{kmA9}) + Raf_star})) + \frac{Raf_star_star PP2A VmaxH4}{kmH4 (one + \frac{Raf_star}{kmH3} + \frac{MAPKK_star_star}{kmH9} + \frac{MAPKK_star}{kmH8}) + Raf_star_star} \frac{d}{d t} (Raf_star_star) = \frac{Raf_star MAPK_star VmaxH2}{kmH2 (one + \frac{SOS}{kmA9}) + Raf_star} - (\frac{Raf_star_star PP2A VmaxH4}{kmH4 (one + \frac{Raf_star}{kmH3} + \frac{MAPKK_star_star}{kmH9} + \frac{MAPKK_star}{kmH8}) + Raf_star_star})

Component: H_Model_Module_MAPKK

\frac{d}{d t} (MAPKK) = \frac{(- MAPKK) VmaxH6 GTPRasRaf_star}{kmH6 (one + \frac{MAPKK_star}{kmH7}) + MAPKK} + \frac{MAPKK_star VmaxH8 PP2A}{kmH8 (one + \frac{Raf_star}{kmH3} + \frac{Raf_star_star}{kmH4} + \frac{MAPKK_star_star}{kmH9}) + MAPKK_star} \frac{d}{d t} (MAPKK_star) = (\frac{MAPKK VmaxH6 GTPRasRaf_star}{kmH6 (one + \frac{MAPKK_star}{kmH7}) + MAPKK} - (\frac{MAPKK_star VmaxH8 PP2A}{kmH8 (one + \frac{Raf_star}{kmH3} + \frac{Raf_star_star}{kmH4} + \frac{MAPKK_star_star}{kmH9}) + MAPKK_star}) - (\frac{MAPKK_star VmaxH7 GTPRasRaf_star}{kmH7 (one + \frac{MAPKK}{kmH6}) + MAPKK_star})) + \frac{MAPKK_star_star VmaxH9 PP2A}{kmH9 (one + \frac{Raf_star}{kmH3} + \frac{Raf_star_star}{kmH4} + \frac{MAPKK_star}{kmH8}) + MAPKK_star_star} \frac{d}{d t} (MAPKK_star_star) = \frac{MAPKK_star VmaxH7 GTPRasRaf_star}{kmH7 (one + \frac{MAPKK}{kmH6}) + MAPKK_star} - (\frac{MAPKK_star_star VmaxH9 PP2A}{kmH9 (one + \frac{Raf_star}{kmH3} + \frac{Raf_star_star}{kmH4} + \frac{MAPKK_star}{kmH8}) + MAPKK_star_star})

Component: H_Model_Module_MAPK

\frac{d}{d t} (MAPK) = \frac{(- MAPK) VmaxH10 MAPKK_star_star}{kmH10 (one + \frac{MAPK_tyr}{kmH11}) + MAPK} + \frac{MAPK_tyr VmaxH12 MKP1}{kmH12 (one + \frac{MAPK_star}{kmH13}) + MAPK_tyr} \frac{d}{d t} (MAPK_tyr) = (\frac{MAPK VmaxH10 MAPKK_star_star}{\frac{kmH10 MAPK_tyr}{kmH11} + MAPK} - (\frac{MAPK_tyr VmaxH12 MKP1}{kmH12 (one + \frac{MAPK_star}{kmH13}) + MAPK_tyr}) - (\frac{MAPK_tyr VmaxH11 MAPKK_star_star}{kmH11 (one + \frac{MAPK_tyr}{kmH12}) + MAPK_tyr})) + \frac{MAPK_star VmaxH13 MKP1}{kmH13 (one + \frac{MAPK_tyr}{kmH12}) + MAPK_star} \frac{d}{d t} (MAPK_star) = \frac{MAPK_tyr VmaxH11 MAPKK_star_star}{kmH11 (one + \frac{MAPK}{kmH10}) + MAPK_tyr} - (\frac{MAPK_star VmaxH13 MKP1}{kmH13 (one + \frac{MAPK_tyr}{kmH12}) + MAPK_star})

Component: A_Model_Module_SHC

\frac{d}{d t} (SHCstar) = (\frac{EGF_EGFR VmaxA3 SHC}{kmA3 (one + \frac{CaPLCg}{kmF4}) + SHC} - (kfA6 SHCstar SOS_GRB2)) + kbA6 SHCstar_SOS_GRB2 - (kfA4 SHCstar) \frac{d}{d t} (SHC) = kfA4 SHCstar - (kbA4 SHC) - (\frac{EGF_EGFR VmaxA3 SHC}{kmA3 (one + \frac{CaPLCg}{kmF4}) + SHC}) \frac{d}{d t} (SHCstar_SOS_GRB2) = kfA6 SHCstar SOS_GRB2 - (kbA6 SHCstar_SOS_GRB2) \frac{d}{d t} (SOS_GRB2) = ((- kfA6) SHCstar SOS_GRB2 + kbA6 SHCstar_SOS_GRB2 - (kbA5 SOS_GRB2)) + kfA5 SOS GRB2 \frac{d}{d t} (SOS) = (kfA8 SOSstar - (kbA8 SOS) - (\frac{MAPK_star VmaxA9 SOS}{kmA9 (one + \frac{Raf_star}{kmH2}) + SOS})) + kbA5 SOS_GRB2 - (kfA5 SOS GRB2) \frac{d}{d t} (SOSstar) = ((- kfA8) SOSstar + kbA8 SOS + \frac{MAPK_star VmaxA9 SOS}{kmA9 (one + \frac{Raf_star}{kmH2}) + SOS} - (kfA10 SOSstar GRB2)) + kbA10 SOSstar_GRB2 \frac{d}{d t} (SOSstar_GRB2) = kfA10 SOSstar GRB2 - (kbA10 SOSstar_GRB2) \frac{d}{d t} (GRB2) = (kbA5 SOS_GRB2 - (kfA5 SOS GRB2) - (kfA10 SOSstar GRB2)) + kbA10 SOSstar_GRB2

Component: A_Model_Module_EGFR

\frac{d}{d t} (EGF) = (- kfA1) EGF EGFR + kbA1 EGF_EGFR \frac{d}{d t} (EGFR) = (- kfA1) EGF EGFR + kbA1 EGF_EGFR \frac{d}{d t} (EGF_EGFR) = (kfA1 EGF EGFR - (kbA1 EGF_EGFR) - (kfA2 EGF_EGFR)) + kbA2 EGF_EGFR_INTERNAL \frac{d}{d t} (EGF_EGFR_INTERNAL) = kfA2 EGF_EGFR - (kbA2 EGF_EGFR_INTERNAL)

Component: F_Model_Module_PLC

\frac{d}{d t} (PLCg) = (- Ca) PLCg kfF1 + CaPLCg kbF1 \frac{d}{d t} (CaPLCg) = (- ((- Ca) PLCg kfF1 + CaPLCg kbF1)) + kfF3 CaPLCg_star - (\frac{VmaxF4 EGF_EGFR CaPLCg}{kmF4 (one + \frac{SHC}{kmA3}) + CaPLCg}) \frac{d}{d t} (CaPLCg_star) = (- (kfF3 CaPLCg_star - (\frac{VmaxF4 EGF_EGFR CaPLCg}{kmF4 + CaPLCg}))) + Ca PLCg_star kfF5 - (kbF5 CaPLCg_star) \frac{d}{d t} (PLCg_star) = (- Ca) PLCg_star kfF5 + kbF5 CaPLCg_star

Component: KEL_DAGIP3_Model_Modules

\frac{d}{d t} (PKC_i) = ((((- PKC_i) kfK1 + PKC kbK1 - (PKC_i AA kfK2)) + PKC kbK2 - (PKC_i DAG kfK9)) + DAGPKC kbK9 - (PKC_i Ca kfK7)) + CaPKC kbK7 \frac{d}{d t} (DAGPKC) = (PKC_i DAG kfK9 - (DAGPKC kbK9) - (DAGPKC AA kfK10)) + AADAGPKC kbK10 \frac{d}{d t} (AADAGPKC) = (DAGPKC AA kfK10 - (AADAGPKC kbK10) - (AADAGPKC kfK6)) + PKC kbK6 \frac{d}{d t} (CaPKC) = (((PKC_i Ca kfK7 - (CaPKC kbK7) - (CaPKC kfK3)) + PKC kbK3 - (CaPKC AA kfK4)) + PKC kbK4 - (DAG CaPKC kfK8)) + DAGCaPKC kbK8 \frac{d}{d t} (DAGCaPKC) = (DAG CaPKC kfK8 - (DAGCaPKC kbK8) - (DAGCaPKC kfK5)) + PKC kbK5 \frac{d}{d t} (PKC) = (((((PKC_i kfK1 - (PKC kbK1)) + PKC_i AA kfK2 - (PKC kbK2)) + CaPKC kfK3 - (PKC kbK3)) + CaPKC AA kfK4 - (PKC kbK4)) + DAGCaPKC kfK5 - (PKC kbK5)) + AADAGPKC kfK6 - (PKC kbK6) \frac{d}{d t} (AA) = ((((- PKC_i) AA kfK2 + PKC kbK2 - (CaPKC AA kfK4)) + PKC kbK4 - (DAGPKC AA kfK10)) + AADAGPKC kbK10 - (AA kfE13)) + \frac{CaPLA2_star VmaxE12 APC}{kmE12 + APC} + \frac{CaPLA2 VmaxE4 APC}{kmE4 + APC} + \frac{DAGCaPLA2 VmaxE8 APC}{kmE8 + APC} + \frac{PIP2CaPLA2 VmaxE6 APC}{kmE6 + APC} + \frac{PIP2PLA2 VmaxE2 APC}{kmE2 + APC} \frac{d}{d t} (PLA2_cyt) = ((PLA2_star kfE10 - (PIP2_star PLA2_cyt kfE1)) + PIP2PLA2 kbE1 - (Ca PLA2_cyt kfE3)) + CaPLA2 kbE3 - (\frac{MAPK VmaxE9 PLA2_cyt}{kmE9 + PLA2_cyt}) \frac{d}{d t} (PIP2PLA2) = PIP2_star PLA2_cyt kfE1 - (PIP2PLA2 kbE1) \frac{d}{d t} (PIP2_star) = ((- PIP2_star) PLA2_cyt kfE1 + PIP2PLA2 kbE1 - (PIP2_star CaPLA2 kfE5)) + PIP2CaPLA2 kbE5 \frac{d}{d t} (PLA2_star) = ((- PLA2_star) kfE10 + \frac{MAPK VmaxE9 PLA2_cyt}{kmE9 + PLA2_cyt} - (Ca PLA2_star kfE11)) + CaPLA2_star kbE11 \frac{d}{d t} (CaPLA2_star) = Ca PLA2_star kfE11 - (CaPLA2_star kbE11) \frac{d}{d t} (CaPLA2) = ((Ca PLA2_cyt kfE3 - (CaPLA2 kbE3) - (DAG CaPLA2 kfE7)) + DAGCaPLA2 kbE7 - (PIP2_star CaPLA2 kfE5)) + PIP2CaPLA2 kbE5 \frac{d}{d t} (PIP2CaPLA2) = PIP2_star CaPLA2 kfE5 - (PIP2CaPLA2 kbE5) \frac{d}{d t} (DAGCaPLA2) = DAG CaPLA2 kfE7 - (DAGCaPLA2 kbE7) \frac{d}{d t} (APC) = AA kfE13 - (\frac{CaPLA2_star VmaxE12 APC}{kmE12 + APC} + \frac{CaPLA2 VmaxE4 APC}{kmE4 + APC} + \frac{DAGCaPLA2 VmaxE8 APC}{kmE8 + APC} + \frac{PIP2CaPLA2 VmaxE6 APC}{kmE6 + APC} + \frac{PIP2PLA2 VmaxE2 APC}{kmE2 + APC}) \frac{d}{d t} (PIP2) = \frac{(- CaPLCg) VmaxF2 PIP2}{kmF2 + PIP2} - (\frac{CaPLCg_star VmaxF6 PIP2}{kmF6 + PIP2}) - (\frac{CaPLC VmaxG7 PIP2}{kmG7 + PIP2}) - (\frac{CaGqPLC VmaxG6 PIP2}{kmG6 + PIP2}) \frac{d}{d t} (DAG) = ((((\frac{CaPLCg VmaxF2 PIP2}{kmF2 + PIP2} + \frac{CaPLCg_star VmaxF6 PIP2}{kmF6 + PIP2} + \frac{CaPLC VmaxG7 PIP2}{kmG7 + PIP2} - (kfG8 DAG)) + \frac{CaGqPLC VmaxG6 PIP2}{kmG6 + PIP2} - (PKC_i DAG kfK9)) + DAGPKC kbK9 - (DAG CaPKC kfK8)) + DAGCaPKC kbK8 - (DAG CaPLA2 kfE7)) + DAGCaPLA2 kbE7 \frac{d}{d t} (IP3) = (\frac{CaPLCg VmaxF2 PIP2}{kmF2 + PIP2} + \frac{CaPLCg_star VmaxF6 PIP2}{kmF6 + PIP2} + \frac{CaGqPLC VmaxG6 PIP2}{kmG6 + PIP2} - (kfG9 IP3)) + \frac{CaPLC VmaxG7 PIP2}{kmG7 + PIP2} \frac{d}{d t} (PC) = kfG8 DAG \frac{d}{d t} (Inositol) = kfG9 IP3

Source: Derived from workspace Bhalla, Iyengar, 1999 at changeset 0d5503f0b7c7.; This exposure was expired. A more up-to-date exposure is available, or view related resources.

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