A dynamical model for the pulsatile secretion of the hypothalamo-pituitary-adrenal axis

Model Status

This CellML model runs in PCenv, COR and OpenCell to recreate the published results. The initial conditions were not explicitly defined in the paper, but were extrapolated from Table 1 and Figure 2. The model was then run until it reached a steady state, and new intial values were taken from the steady state.

Model Structure

ABSTRACT: We propose a dynamical model for the pulsatile secretion of the hypothalamo-pituitary-adrenal axis. This model takes into account both the binding of hormone with proteins in the plasma and tissues and mutual interactions of the hormones in the system. The deductions from this model are in good agreement with experiment results.

Schematic diagram of the hormone flow and interactions between the different components of the hypothalamic-pituitary-adrenal (HPA) axis which are described by the mathematical model. CRH represents corticotropin releasing hormone, ACTH represents corticotropin, and CBG is corticosteroid binding globulin. Red arrows represent hormone disposal, while black arrows represent flow between the different glands and plasma. + represents a stimulatory effect while - represents an inhibitory effect.

The original paper reference is cited below:

A dynamical model for the pulsatile secretion of the hypothalamo-pituitary-adrenal axis, Yi-Wei Liu, Zhi-Hong Hu, Jian-Hua Peng, and Bing-Zheng Liu, 1999, Mathematical and Computer Modelling, 29 (Issue 4), 103-110. (No Pubmed ID)