Fast sodium current in cardiac muscle: A quantitative description

Model Status

This is the original unchecked version of the model imported from the previous CellML model repository, 24-Jan-2006.

Model Structure

In 1980, Lisa Ebihara and Edward A. Johnson published the first electrophysiological model to specifically target a single ion channel and attempt to quantify its parameters. They used the Hodgkin-Huxley formulation to revise the parameters of the fast sodium current in cardiac muscle. This model exhibits a faster sodium current than the Beeler-Reuter model, and when the two models are coupled, the Ebihara-Johnson can be used as a direct replacement of the sodium kinetics of the Beeler-Reuter.

Schematic diagram of the Ebihara and Johnson model.

The complete original paper reference is cited below:

Fast Sodium Current In Cardiac Muscle, Lisa Ebihara and Edward A. Johnson, 1980, Biophys. J. 32, 779-790. PubMed ID: 7260301

The raw CellML description of the Ebihara-Johnson model can be downloaded in various formats as described in . For an example of a more complete documentation for an electrophysiological model, see The Hodgkin-Huxley Squid Axon Model, 1952.