Minimal Model of beta-cell mitochondrial Ca2+ handling

Model Status

This is the original unchecked version of the model imported from the previous CellML model repository, 24-Jan-2006.

Model Structure

In 1997 Gerhard Magnus and Joel Keizer published a minimal mathematical model to describe Ca²⁺ handling by mitochondria in the pancreatic beta-cell. Their kinetic model includes six transport mechanisms in the inner mitochondrial membrane, including proton pumping via respiration and proton pumping by the F0F1-ATPase, a proton leak, adenine nucleotide exchange, the Ca²⁺ uniporter and Na⁺/Ca²⁺ exchange (see the figure below).

The complete original paper reference is cited below:

Minimal model of beta-cell mitochondrial Ca²⁺ handling, Gerhard Magnus and Joel Keizer, 1997, American Journal of Physiology , 273, C717-C733. PubMed ID: 9277370

The raw CellML description of the mitochondrial Ca²⁺ handling model can be downloaded in various formats as described in . For an example of a more complete documentation for an electrophysiological model, see The Hodgkin-Huxley Squid Axon Model, 1952.

A schematic representation of the ion fluxes through the mitochondrial inner membrane that are included in the Magnus-Keizer minimal model.

The network defined in the CellML description of the mitochondrial Ca2+ handling model.