# Model Mathematics

### Component: PKACII_RyR

$PKACII_RyR = PKACII_RyRtot + epsilon ⁢ RyR ⁢ PKACII_RyR Ks_RyR_PKAC$

### Component: PP1_RyR

$PP1_RyR = PP1_RyRtot + epsilon ⁢ RyRp ⁢ PP1_RyR Ks_RyR_PP1$

### Component: PP2A_RyR

$PP2A_RyR = PP2A_RyRtot + epsilon ⁢ RyRp ⁢ PP2A_RyR Ks_RyR_PP2A$

### Component: RyR

$RyR = RyRtot + epsilon ⁢ RyR ⁢ PKACII_RyR Ks_RyR_PKAC$

### Component: RyRp

$RyRp = RyRptot + epsilon ⁢ RyRp ⁢ PP1_RyR Ks_RyR_PP1 + epsilon ⁢ RyRp ⁢ PP2A_RyR Ks_RyR_PP2A$

### Component: RyRtot

$RyRtot = RyRsum - RyRptot$

### Component: RyRptot

$ddtimeRyRptot= kPKA_RyR ⁢ epsilon ⁢ RyR ⁢ PKACII_RyR Ks_RyR_PKAC - kPP1_RyR ⁢ epsilon ⁢ RyRp ⁢ PP1_RyR Ks_RyR_PP1 + kPP2A_RyR ⁢ epsilon ⁢ RyRp ⁢ PP2A_RyR Ks_RyR_PP2A$

### Component: KMrel

$KMrel = 1.64 1.0 + RyRptot RyRsum ⁢ KMrel0$

### Component: TnI

$TnI = TnItot - TnIp$

### Component: TnIp

$ddtimeTnIp= kPKA_TnI ⁢ PKAC ⁢ TnI KM_PKA_TnI + TnIp - kPP2A_TnI ⁢ PP2A ⁢ TnIp KM_PP2A_TnI + TnIp$

### Component: KMTnC

$KMTnC = 1.0 + 0.45 + TnIp TnItot ⁢ KMTnC0$

### Component: kinetic_parameters

Source
Derived from workspace Saucerman, Mcculloch, 2004 at changeset 3753a2fd25b8.
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