Model Mathematics

Component: environment

Component: membrane

ddtimeV=-i_Ca+i_K+i_K_ATP+i_K_Ca+i_CRAC+i_leakCm

Component: K_current

i_K=g_KnV-V_K

Component: K_channel_n_gate

ddtimen=lambda_nn_infinity-ntau_n n_infinity=11+Vn-VSn tau_n=9.091+V-VnSn

Component: K_ATP_current

i_K_ATP=g_K_ATPV-V_K

Component: fast_Ca_current

i_Ca_f=g_Ca_fm_f_infinityV-V_Ca

Component: fast_Ca_channel_m_gate

m_f_infinity=11+Vm_f-VSm_f

Component: slow_Ca_current

i_Ca_s=g_Ca_sm_s_infinity1-jmV-V_Ca

Component: slow_Ca_channel_m_gate

m_s_infinity=11+Vm_s-VSm_s

Component: slow_Ca_channel_j_gate

j=1-jm jm_infinity=1-11+V-VjSj tau_j=50000V-Vj4+Vj-V4+1500 ddtimejm=jm_infinity-jmtau_j

Component: Ca_current_total

i_Ca=i_Ca_f+i_Ca_s

Component: K_Ca_current

i_K_Ca=g_K_CaCa_i5Ca_i5+kdkca5V-V_K

Component: CRAC_current

i_CRAC=g_CRACr_infinityV-V_CRAC

Component: CRAC_r_gate

r_infinity=11+1Ca_er-Ca_er_bar

Component: leak_current

i_leak=g_leakV-V_CRAC

Component: ER_parameters

J_er_p=verpCa_i2Ca_i2+kerp2 a_infinity=11+dactCa_i b_infinity=IP3IP3+dip3 h_infinity=11+Ca_idinh O=a_infinity3b_infinity3h_infinity31

Component: Ca_equations

J_er_tot=J_er_leak+J_er_IP3-J_er_p J_er_leak=perlCa_er-Ca_i J_er_IP3=OCa_er-Ca_i ddtimeCa_er=-J_er_totlambda_ersigma_er ddtimeCa_i=J_er_totlambda_er+J_mem_tot

Component: Ca_membrane_flux

J_mem_tot=-fgammai_Ca+k_CaCa_i