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/* There are a total of 24 entries in the algebraic variable array. There are a total of 5 entries in each of the rate and state variable arrays. There are a total of 35 entries in the constant variable array. */ /* * VOI is time in component environment (millisecond). * STATES[0] is V in component membrane (millivolt). * CONSTANTS[0] is Cm in component membrane (femtoF). * ALGEBRAIC[1] is i_K in component K_current (picoA). * ALGEBRAIC[12] is i_K_Ca in component K_Ca_current (picoA). * ALGEBRAIC[5] is i_K_ATP in component K_ATP_current (picoA). * ALGEBRAIC[16] is i_CRAC in component CRAC_current (picoA). * ALGEBRAIC[11] is i_Ca in component Ca_current_total (picoA). * ALGEBRAIC[18] is i_leak in component leak_current (picoA). * CONSTANTS[1] is V_K in component K_current (millivolt). * CONSTANTS[2] is g_K in component K_current (picoS). * STATES[1] is n in component K_channel_n_gate (dimensionless). * ALGEBRAIC[0] is n_infinity in component K_channel_n_gate (dimensionless). * ALGEBRAIC[4] is tau_n in component K_channel_n_gate (millisecond). * CONSTANTS[3] is Vn in component K_channel_n_gate (millivolt). * CONSTANTS[4] is Sn in component K_channel_n_gate (millivolt). * CONSTANTS[5] is lambda_n in component K_channel_n_gate (dimensionless). * CONSTANTS[6] is g_K_ATP in component K_ATP_current (picoS). * ALGEBRAIC[8] is i_Ca_f in component fast_Ca_current (picoA). * CONSTANTS[7] is V_Ca in component fast_Ca_current (millivolt). * CONSTANTS[8] is g_Ca_f in component fast_Ca_current (picoS). * ALGEBRAIC[7] is m_f_infinity in component fast_Ca_channel_m_gate (dimensionless). * CONSTANTS[9] is Vm_f in component fast_Ca_channel_m_gate (millivolt). * CONSTANTS[10] is Sm_f in component fast_Ca_channel_m_gate (millivolt). * ALGEBRAIC[10] is i_Ca_s in component slow_Ca_current (picoA). * CONSTANTS[11] is g_Ca_s in component slow_Ca_current (picoS). * ALGEBRAIC[9] is m_s_infinity in component slow_Ca_channel_m_gate (dimensionless). * STATES[2] is jm in component slow_Ca_channel_j_gate (dimensionless). * CONSTANTS[12] is Vm_s in component slow_Ca_channel_m_gate (millivolt). * CONSTANTS[13] is Sm_s in component slow_Ca_channel_m_gate (millivolt). * ALGEBRAIC[2] is j in component slow_Ca_channel_j_gate (dimensionless). * ALGEBRAIC[3] is jm_infinity in component slow_Ca_channel_j_gate (dimensionless). * CONSTANTS[14] is Vj in component slow_Ca_channel_j_gate (millivolt). * ALGEBRAIC[6] is tau_j in component slow_Ca_channel_j_gate (millisecond). * CONSTANTS[15] is Sj in component slow_Ca_channel_j_gate (millivolt). * CONSTANTS[16] is g_K_Ca in component K_Ca_current (picoS). * STATES[3] is Ca_i in component Ca_equations (micromolar). * CONSTANTS[17] is kdkca in component K_Ca_current (micromolar). * CONSTANTS[18] is g_CRAC in component CRAC_current (picoS). * CONSTANTS[19] is V_CRAC in component CRAC_current (millivolt). * STATES[4] is Ca_er in component Ca_equations (micromolar). * ALGEBRAIC[14] is r_infinity in component CRAC_r_gate (dimensionless). * CONSTANTS[20] is Ca_er_bar in component CRAC_r_gate (micromolar). * CONSTANTS[21] is g_leak in component leak_current (picoS). * ALGEBRAIC[13] is J_er_p in component ER_parameters (micromolar_per_millisecond). * CONSTANTS[22] is IP3 in component ER_parameters (micromolar). * CONSTANTS[23] is kerp in component ER_parameters (micromolar). * CONSTANTS[24] is verp in component ER_parameters (micromolar_per_millisecond). * CONSTANTS[25] is dact in component ER_parameters (micromolar). * CONSTANTS[26] is dinh in component ER_parameters (micromolar). * CONSTANTS[27] is dip3 in component ER_parameters (micromolar). * ALGEBRAIC[15] is a_infinity in component ER_parameters (dimensionless). * CONSTANTS[34] is b_infinity in component ER_parameters (dimensionless). * ALGEBRAIC[17] is h_infinity in component ER_parameters (dimensionless). * ALGEBRAIC[19] is O in component ER_parameters (per_millisecond). * ALGEBRAIC[22] is J_er_tot in component Ca_equations (micromolar_per_millisecond). * ALGEBRAIC[21] is J_er_IP3 in component Ca_equations (micromolar_per_millisecond). * ALGEBRAIC[20] is J_er_leak in component Ca_equations (micromolar_per_millisecond). * ALGEBRAIC[23] is J_mem_tot in component Ca_membrane_flux (micromolar_per_millisecond). * CONSTANTS[28] is perl in component Ca_equations (per_millisecond). * CONSTANTS[29] is lambda_er in component Ca_equations (dimensionless). * CONSTANTS[30] is sigma_er in component Ca_equations (dimensionless). * CONSTANTS[31] is k_Ca in component Ca_membrane_flux (per_millisecond). * CONSTANTS[32] is gamma in component Ca_membrane_flux (micromolar_per_millisecond_picoA). * CONSTANTS[33] is f in component Ca_membrane_flux (dimensionless). * RATES[0] is d/dt V in component membrane (millivolt). * RATES[1] is d/dt n in component K_channel_n_gate (dimensionless). * RATES[2] is d/dt jm in component slow_Ca_channel_j_gate (dimensionless). * RATES[4] is d/dt Ca_er in component Ca_equations (micromolar). * RATES[3] is d/dt Ca_i in component Ca_equations (micromolar). */ void initConsts(double* CONSTANTS, double* RATES, double *STATES) { STATES[0] = -61; CONSTANTS[0] = 6158; CONSTANTS[1] = -70; CONSTANTS[2] = 3900; STATES[1] = 0.0005; CONSTANTS[3] = -15; CONSTANTS[4] = 6; CONSTANTS[5] = 1.85; CONSTANTS[6] = 150; CONSTANTS[7] = 100; CONSTANTS[8] = 810; CONSTANTS[9] = -20; CONSTANTS[10] = 7.5; CONSTANTS[11] = 510; STATES[2] = 0.12; CONSTANTS[12] = -16; CONSTANTS[13] = 10; CONSTANTS[14] = -53; CONSTANTS[15] = 2; CONSTANTS[16] = 1200; STATES[3] = 0.11; CONSTANTS[17] = 0.55; CONSTANTS[18] = 75; CONSTANTS[19] = 0; STATES[4] = 9; CONSTANTS[20] = 3; CONSTANTS[21] = 0; CONSTANTS[22] = 0; CONSTANTS[23] = 0.1; CONSTANTS[24] = 0.24; CONSTANTS[25] = 0.1; CONSTANTS[26] = 0.4; CONSTANTS[27] = 0.2; CONSTANTS[28] = 0.02; CONSTANTS[29] = 250; CONSTANTS[30] = 5; CONSTANTS[31] = 0.07; CONSTANTS[32] = 0.000003607; CONSTANTS[33] = 0.01; CONSTANTS[34] = CONSTANTS[22]/(CONSTANTS[22]+CONSTANTS[27]); } void computeRates(double VOI, double* CONSTANTS, double* RATES, double* STATES, double* ALGEBRAIC) { ALGEBRAIC[0] = 1.00000/(1.00000+exp((CONSTANTS[3] - STATES[0])/CONSTANTS[4])); ALGEBRAIC[4] = 9.09000/(1.00000+exp((STATES[0] - CONSTANTS[3])/CONSTANTS[4])); RATES[1] = ( CONSTANTS[5]*(ALGEBRAIC[0] - STATES[1]))/ALGEBRAIC[4]; ALGEBRAIC[3] = 1.00000 - 1.00000/(1.00000+exp((STATES[0] - CONSTANTS[14])/CONSTANTS[15])); ALGEBRAIC[6] = 50000.0/(exp((STATES[0] - CONSTANTS[14])/4.00000)+exp((CONSTANTS[14] - STATES[0])/4.00000))+1500.00; RATES[2] = (ALGEBRAIC[3] - STATES[2])/ALGEBRAIC[6]; ALGEBRAIC[1] = CONSTANTS[2]*STATES[1]*(STATES[0] - CONSTANTS[1]); ALGEBRAIC[12] = (( CONSTANTS[16]*pow(STATES[3], 5.00000))/(pow(STATES[3], 5.00000)+pow(CONSTANTS[17], 5.00000)))*(STATES[0] - CONSTANTS[1]); ALGEBRAIC[5] = CONSTANTS[6]*(STATES[0] - CONSTANTS[1]); ALGEBRAIC[14] = 1.00000/(1.00000+exp( 1.00000*(STATES[4] - CONSTANTS[20]))); ALGEBRAIC[16] = CONSTANTS[18]*ALGEBRAIC[14]*(STATES[0] - CONSTANTS[19]); ALGEBRAIC[7] = 1.00000/(1.00000+exp((CONSTANTS[9] - STATES[0])/CONSTANTS[10])); ALGEBRAIC[8] = CONSTANTS[8]*ALGEBRAIC[7]*(STATES[0] - CONSTANTS[7]); ALGEBRAIC[9] = 1.00000/(1.00000+exp((CONSTANTS[12] - STATES[0])/CONSTANTS[13])); ALGEBRAIC[10] = CONSTANTS[11]*ALGEBRAIC[9]*(1.00000 - STATES[2])*(STATES[0] - CONSTANTS[7]); ALGEBRAIC[11] = ALGEBRAIC[8]+ALGEBRAIC[10]; ALGEBRAIC[18] = CONSTANTS[21]*(STATES[0] - CONSTANTS[19]); RATES[0] = - (ALGEBRAIC[11]+ALGEBRAIC[1]+ALGEBRAIC[5]+ALGEBRAIC[12]+ALGEBRAIC[16]+ALGEBRAIC[18])/CONSTANTS[0]; ALGEBRAIC[13] = ( CONSTANTS[24]*pow(STATES[3], 2.00000))/(pow(STATES[3], 2.00000)+pow(CONSTANTS[23], 2.00000)); ALGEBRAIC[15] = 1.00000/(1.00000+CONSTANTS[25]/STATES[3]); ALGEBRAIC[17] = 1.00000/(1.00000+STATES[3]/CONSTANTS[26]); ALGEBRAIC[19] = pow(ALGEBRAIC[15], 3.00000)*pow(CONSTANTS[34], 3.00000)*pow(ALGEBRAIC[17], 3.00000)*1.00000; ALGEBRAIC[21] = ALGEBRAIC[19]*(STATES[4] - STATES[3]); ALGEBRAIC[20] = CONSTANTS[28]*(STATES[4] - STATES[3]); ALGEBRAIC[22] = (ALGEBRAIC[20]+ALGEBRAIC[21]) - ALGEBRAIC[13]; RATES[4] = - ALGEBRAIC[22]/( CONSTANTS[29]*CONSTANTS[30]); ALGEBRAIC[23] = - CONSTANTS[33]*( CONSTANTS[32]*ALGEBRAIC[11]+ CONSTANTS[31]*STATES[3]); RATES[3] = ALGEBRAIC[22]/CONSTANTS[29]+ALGEBRAIC[23]; } void computeVariables(double VOI, double* CONSTANTS, double* RATES, double* STATES, double* ALGEBRAIC) { ALGEBRAIC[0] = 1.00000/(1.00000+exp((CONSTANTS[3] - STATES[0])/CONSTANTS[4])); ALGEBRAIC[4] = 9.09000/(1.00000+exp((STATES[0] - CONSTANTS[3])/CONSTANTS[4])); ALGEBRAIC[3] = 1.00000 - 1.00000/(1.00000+exp((STATES[0] - CONSTANTS[14])/CONSTANTS[15])); ALGEBRAIC[6] = 50000.0/(exp((STATES[0] - CONSTANTS[14])/4.00000)+exp((CONSTANTS[14] - STATES[0])/4.00000))+1500.00; ALGEBRAIC[1] = CONSTANTS[2]*STATES[1]*(STATES[0] - CONSTANTS[1]); ALGEBRAIC[12] = (( CONSTANTS[16]*pow(STATES[3], 5.00000))/(pow(STATES[3], 5.00000)+pow(CONSTANTS[17], 5.00000)))*(STATES[0] - CONSTANTS[1]); ALGEBRAIC[5] = CONSTANTS[6]*(STATES[0] - CONSTANTS[1]); ALGEBRAIC[14] = 1.00000/(1.00000+exp( 1.00000*(STATES[4] - CONSTANTS[20]))); ALGEBRAIC[16] = CONSTANTS[18]*ALGEBRAIC[14]*(STATES[0] - CONSTANTS[19]); ALGEBRAIC[7] = 1.00000/(1.00000+exp((CONSTANTS[9] - STATES[0])/CONSTANTS[10])); ALGEBRAIC[8] = CONSTANTS[8]*ALGEBRAIC[7]*(STATES[0] - CONSTANTS[7]); ALGEBRAIC[9] = 1.00000/(1.00000+exp((CONSTANTS[12] - STATES[0])/CONSTANTS[13])); ALGEBRAIC[10] = CONSTANTS[11]*ALGEBRAIC[9]*(1.00000 - STATES[2])*(STATES[0] - CONSTANTS[7]); ALGEBRAIC[11] = ALGEBRAIC[8]+ALGEBRAIC[10]; ALGEBRAIC[18] = CONSTANTS[21]*(STATES[0] - CONSTANTS[19]); ALGEBRAIC[13] = ( CONSTANTS[24]*pow(STATES[3], 2.00000))/(pow(STATES[3], 2.00000)+pow(CONSTANTS[23], 2.00000)); ALGEBRAIC[15] = 1.00000/(1.00000+CONSTANTS[25]/STATES[3]); ALGEBRAIC[17] = 1.00000/(1.00000+STATES[3]/CONSTANTS[26]); ALGEBRAIC[19] = pow(ALGEBRAIC[15], 3.00000)*pow(CONSTANTS[34], 3.00000)*pow(ALGEBRAIC[17], 3.00000)*1.00000; ALGEBRAIC[21] = ALGEBRAIC[19]*(STATES[4] - STATES[3]); ALGEBRAIC[20] = CONSTANTS[28]*(STATES[4] - STATES[3]); ALGEBRAIC[22] = (ALGEBRAIC[20]+ALGEBRAIC[21]) - ALGEBRAIC[13]; ALGEBRAIC[23] = - CONSTANTS[33]*( CONSTANTS[32]*ALGEBRAIC[11]+ CONSTANTS[31]*STATES[3]); ALGEBRAIC[2] = 1.00000 - STATES[2]; }