Mitochondrial energetic metabolism: a simplified model of TCA cycle with ATP production (scaled version)

Model Status

This CellML runs in both OpenCell and COR. It is the scaled version of the model, taken from equations 29-39 in the original paper. Unfortunately the CellMl model does not recreate the published results and it requires further curation.

Model Structure

ABSTRACT: Mitochondria play a central role in cellular energetic metabolism. The essential parts of this metabolism are the tricarboxylic acid (TCA) cycle, the respiratory chain and the adenosine triphosphate (ATP) synthesis machinery. Here a simplified model of these three metabolic components with a limited set of differential equations is presented. The existence of a steady state is demonstrated and results of numerical simulations are presented. The relevance of a simple model to represent actual in vivo behavior is discussed.

The original paper reference is cited below:

Mitochondrial energetic metabolism: a simplified model of TCA cycle with ATP production, Nazaret C, Heiske M, Thurley K, and Mazat JP, 2009, Journal of Theoretical Biology, 258, 455-464. PubMed ID: 19007794

Schematic diagram of the model.