Model Mathematics

Component: environment

Component: free_protein_calcium_binding_sites

dd time Pr = k_minus CaPr - k_plus Ca_cyt Pr CaPr = Pr_tot - Pr

Component: cytosolic_calcium

dd time Ca_cyt = J_ch + J_leak + k_minus CaPr - J_pump + k_plus Ca_cyt Pr

Component: ER_calcium

Ca_ER = Ca_tot - Ca_cyt + Pr_tot - Pr rho

Component: potential_difference

delta_psi = R T F ln- b - b 2.0 - 4.0 a c 0.5 2.0 a a = rho 2.0 Ca_cyt - 2.0 Pr + A_tot b = C_tot - A_tot + 2.0 Ca_cyt - Pr 1.0 + rho 2.0 c = rho 2.0 Ca_cyt - 2.0 Pr + C_tot

Component: calcium_reversal_potential

E_Ca = R T 2.0 F ln Ca_ER Ca_cyt

Component: flux_through_the_channels

J_ch = k_ch E_Ca - delta_psi k_ch = g_Ca 2.0 F Vcyt g_Ca = g_Ca_max S Ca_cyt K_Ca 2.0 1.0 + Ca_cyt K_Ca 2.0

Component: calcium_pump

J_pump = k_pump Ca_cyt

Component: leak_flux

J_leak = k_leak E_Ca - delta_psi

Component: model_parameters