Model Mathematics

Component: environment

Component: membrane

dd time V = I_stim - i_Na + i_s + i_x1 + i_K1 C

Component: fast_sodium_current

i_Na = g_Na m 3.0 h V - E_Na

Component: fast_sodium_current_m_gate

alpha_m = 890.9437890 0.0486479 V - 4.8647916 1.0 + 5.93962526 0.0486479 V - 4.8647916 if V > 100.0 0.9 V + 42.65 1.0 - -0.22 V - 9.3830 otherwise beta_m = 1.437 -0.085 V - 3.37875 if V > -85.0 100.0 1.0 + 0.486479 0.2597504 V + 22.0787804 otherwise dd time m = alpha_m 1.0 - m - beta_m m

Component: fast_sodium_current_h_gate

alpha_h = 0.1 -0.193 V - 15.37245 if V > -90.0 -12.0662845 - 0.1422598 V otherwise beta_h = 1.7 1.0 + -0.095 V - 1.9475 dd time h = alpha_h 1.0 - h - beta_h h

Component: time_independent_outward_current

i_K1 = 0.35e-2 4.0 0.04 V + 85.0 - 1.0 0.08 V + 53 + 0.04 V + 53.0 + 0.2 V + 23.0 1.0 - -0.04 V + 23.0

Component: time_dependent_outward_current

i_x1 = x1 0.8e-2 0.04 V + 77.0 - 1.0 0.04 V + 35.0

Component: time_dependent_outward_current_x1_gate

alpha_x1 = 151.7994692 0.0654679 V - 26.1871448 1.0 + 1.5179947 0.0654679 V - 26.1871448 if V > 400.0 0.0005 V 0.083 + 4.150 1.0 + 0.057 V + 2.850 otherwise beta_x1 = 0.0013 V -0.06 - 1.2 1.0 + -0.04 V - 0.8 dd time x1 = alpha_x1 1.0 - x1 - beta_x1 x1

Component: slow_inward_current

E_s = -82.3 - 13.0287 ln Cai 0.001 i_s = g_s d f V - E_s dd time Cai = 0.0 if V > 200.0 i_s -0.01 + 0.07 0.0001 - Cai otherwise

Component: slow_inward_current_d_gate

alpha_d = 0.095 - V - 5.0 100.0 1.0 +- V - 5.0 13.89 beta_d = 0.07 - V + 44.0 59.0 1.0 + V + 44.0 20.0 dd time d = alpha_d R_d 1.0 - d - beta_d d

Component: slow_inward_current_f_gate

alpha_f = 0.012 - V + 28.0 125.0 1.0 + V + 28.0 6.67 beta_f = 0.0065 - V + 30.0 50.0 1.0 +- V + 30.0 5.0 dd time f = alpha_f R_f 1.0 - f - beta_f f