MWC_10_test.cellml
MWC-10 model experiment
In the MWC_10_experiment, the MWC-10 model is configured and parameterised with an applied voltage clamp protocol.
You can change the parameters of stimulation in the component clamp_para. You can also bypass the parameters in the components free_para_10 and Para, and define your own parameters.
Steady states
We have used two approaches to get the steady states of system:
- Apply the double pulse protocol and record the simulation when the system reaches plateau (after 200 ms);
- Use Equation (6) and (7) in the primary paper, denoted by ss in the following figures.
The results from these two methods are identical in our simulation.
Figure [1] shows the voltage dependencies and transfer function.
| [1] |
Figure [2] shows the voltage dependencies and transfer function under reference conditions.
| [2] |
Figure [3] shows the voltage dependencies and transfer function under perchlorate conditions, where the simulation for Fiber 911 case does not match well.
| [3] |
Kinetic transients
Figure [4] shows charge movement transients (simulation data are divided by 5) in reference simulation with different test voltages.
| [4] |
Figure [5] shows charge movement transients (simulation data are divided by 5) in perchlorate simulation with different test voltages.
| [5] |
For primary Fig. 11, we have tried different settings in Table 1 and two sets of test voltages, but we couldn't find a perfect match.
Figure [6] shows the open probability and charge movement current when 827 parameters are used.
| [6] |
Figure [7] shows the open probability and charge movement current when 908 parameters are used.
| [7] |
Figure [8] shows the open probability and charge movement current when 906 parameters are used.
| [8] |
Figure [9] shows the open probability and charge movement current when 907 parameters are used.
| [9] |
The following two figures only have simulation results, which show that the qualitative difference between reference and perchlorate conditions agrees with the original figure, that is, perchlorate conditions slow down the transitions.
Figure [10] shows the open probability and charge movement current under reference and perchlorate conditions when 827 parameters are used.
| [10] |
Figure [11] shows the open probability and charge movement current under reference and perchlorate conditions when 908 parameters are used.
| [11] |
