Model Mathematics

Component: output

Component: clamp_para

KCl=X Clo=147+KCl

Component: free_para

Component: noise_G

Component: SMC

Component: Cai

ddtc_i=J_IP3i+J_VOCCi-J_NCXi-J_SERCAi+J_CICRi-J_PMCAi+J_leaki

Component: Casr

ddts_i=J_SERCAi-J_CICRi-J_leaki

Component: IP3

ddtI_i=J_PLCagonisti+J_PLC_delta_i-J_degradi

Component: JCICRi

J_CICRi=Cs_i2s_i2+s_c2c_i4c_i4+c_c4

Component: JCli

J_Cli=G_Clv_i-v_Cl

Component: E_Na

Component: E_Ca

Component: E_K

Component: E_Cl

Component: Nernst_potential

E=RTzFlnX_oX_i

Component: Nernst_potential

E=RTzFlnX_oX_i

Component: Nernst_potential

E=RTzFlnX_oX_i

Component: Nernst_potential

E=RTzFlnX_oX_i

Component: JIP3i

J_IP3i=F_IP3I_i2K_r2+I_i2

Component: JKi

J_Ki=G_Kiw_iv_i-v_K ddtw_i=lambdaK_activationi-w_i K_activationi=c_i+c_w2c_i+c_w2+beta-v_i-v_Ca3R_K

Component: E_Na

Component: E_Ca

Component: E_K

Component: E_Cl

Component: E_NaComp

E=RTzFlnX_oX_i

Component: E_CaComp

E=RTzFlnX_oX_i

Component: E_KComp

E=RTzFlnX_oX_i

Component: E_ClComp

E=RTzFlnX_oX_i

Component: JNCXi

J_NCXi=G_NCXc_ic_i+c_NCXv_NCX-v_i

Component: JNKAi

J_NKAi=F_NKA

Component: JPLCdeltai

J_PLC_delta_i=Ec_i2K_Ca2+c_i2

Component: JPMCAi

J_PMCAi=Dc_i1+v_i-v_dR_d

Component: JSERCAi

J_SERCAi=Bc_i2c_i2+c_b2

Component: JVOCCi

J_VOCCi=G_Cav_Ca1-v_i1+v_Ca2-v_iR_Ca

Component: Jdegradi

J_degradi=kI_i

Component: Jleaki

J_leaki=Ls_i

Component: Vm

ddtv_i=gamma-J_NKAi-J_Cli+2J_VOCCi+J_NCXi-J_Ki

Component: Para

Component: X_clamp_protocol

X=X_Holdingiftime<t_ssX_Testiftimet_sstime<t_act+t_ssX_Holdingotherwise

Component: time_ms

Component: time_s