<?xml version='1.0'?>
<!--
This CellML file was generated on 11/12/2007 at 15:38:26 using:
COR (0.9.31.833)
Copyright 2002-2007 Dr Alan Garny
http://COR.physiol.ox.ac.uk/ - COR@physiol.ox.ac.uk
CellML 1.0 was used to generate this cellular model
http://www.CellML.org/
-->
<model cmeta:id="iyer_2004" name="iyer_2004" xmlns="http://www.cellml.org/cellml/1.0#" xmlns:cellml="http://www.cellml.org/cellml/1.0#" xmlns:cmeta="http://www.cellml.org/metadata/1.0#">
<units name="m2u">
<unit prefix="micro" units="second"/>
<unit exponent="-1" prefix="milli" units="second"/>
</units>
<units name="ms">
<unit prefix="milli" units="second"/>
</units>
<units name="per_ms">
<unit exponent="-1" units="ms"/>
</units>
<units name="micrometer">
<unit prefix="micro" units="metre"/>
</units>
<units name="L">
<unit units="litre"/>
</units>
<units name="uL">
<unit prefix="micro" units="litre"/>
</units>
<units name="N_per_mm2">
<unit units="newton"/>
<unit exponent="-2" prefix="milli" units="metre"/>
</units>
<units name="mm">
<unit prefix="milli" units="meter"/>
</units>
<units name="cm">
<unit prefix="centi" units="meter"/>
</units>
<units name="cm_per_s">
<unit units="cm"/>
<unit exponent="-1" units="second"/>
</units>
<units name="mm3">
<unit exponent="3" units="mm"/>
</units>
<units name="mm2">
<unit exponent="2" units="mm"/>
</units>
<units name="cm2">
<unit exponent="2" units="cm"/>
</units>
<units name="mV">
<unit prefix="milli" units="volt"/>
</units>
<units name="per_mV">
<unit exponent="-1" prefix="milli" units="volt"/>
</units>
<units name="mS">
<unit prefix="milli" units="siemens"/>
</units>
<units name="uF">
<unit prefix="micro" units="farad"/>
</units>
<units name="uA_per_uF">
<unit units="uA"/>
<unit exponent="-1" units="uF"/>
</units>
<units name="mS_per_uF">
<unit units="mS"/>
<unit exponent="-1" units="uF"/>
</units>
<units name="pF">
<unit prefix="pico" units="farad"/>
</units>
<units name="mF">
<unit prefix="milli" units="farad"/>
</units>
<units name="mF_per_cm2">
<unit prefix="milli" units="farad"/>
<unit exponent="-1" units="cm2"/>
</units>
<units name="uF_per_mm2">
<unit prefix="micro" units="farad"/>
<unit exponent="-1" units="mm2"/>
</units>
<units name="F_M_per_coulomb">
<unit units="farad"/>
<unit units="molar"/>
<unit exponent="-1" units="coulomb"/>
</units>
<units name="uA">
<unit prefix="micro" units="ampere"/>
</units>
<units name="molar">
<unit units="mole"/>
<unit exponent="-1" units="litre"/>
</units>
<units name="mM">
<unit prefix="milli" units="mole"/>
<unit exponent="-1" units="litre"/>
</units>
<units name="uM">
<unit prefix="micro" units="mole"/>
<unit exponent="-1" units="litre"/>
</units>
<units name="mM_per_ms">
<unit units="mM"/>
<unit exponent="-1" units="ms"/>
</units>
<units name="per_mM">
<unit exponent="-1" units="mM"/>
</units>
<units name="mM3">
<unit exponent="3" units="mM"/>
</units>
<units name="mM4">
<unit exponent="4" units="mM"/>
</units>
<units name="per_uM3_per_ms">
<unit exponent="-3" units="uM"/>
<unit exponent="-1" units="ms"/>
</units>
<units name="per_uM4_per_ms">
<unit exponent="-4" units="uM"/>
<unit exponent="-1" units="ms"/>
</units>
<units name="litre_per_farad_second">
<unit units="litre"/>
<unit exponent="-1" units="farad"/>
<unit exponent="-1" units="second"/>
</units>
<units name="joule_per_mole_kelvin">
<unit units="joule"/>
<unit exponent="-1" units="mole"/>
<unit exponent="-1" units="kelvin"/>
</units>
<units name="joule_per_kelvin">
<unit units="joule"/>
<unit exponent="-1" units="kelvin"/>
</units>
<units name="joule_ms">
<unit units="joule"/>
<unit units="ms"/>
</units>
<units name="joule_per_mole">
<unit units="joule"/>
<unit exponent="-1" units="mole"/>
</units>
<units name="coulomb_per_millimole">
<unit units="coulomb"/>
<unit exponent="-1" prefix="milli" units="mole"/>
</units>
<units name="per_mM_per_ms">
<unit exponent="-1" units="mM"/>
<unit exponent="-1" units="ms"/>
</units>
<component name="environment">
<variable cmeta:id="environment_time" name="time" public_interface="out" units="ms"/>
</component>
<component name="COMPUTE_CONCENTRATION_AND_VOLTAGE_DERIVATIVES">
<variable name="a1" units="F_M_per_coulomb"/>
<variable name="a2" units="F_M_per_coulomb"/>
<variable initial_value="96.5" name="Faraday" public_interface="out" units="coulomb_per_millimole"/>
<variable initial_value="310" name="Temp" units="kelvin"/>
<variable initial_value="8.315" name="Rgas" public_interface="out" units="joule_per_mole_kelvin"/>
<variable name="RT_over_F" public_interface="out" units="mV"/>
<variable initial_value="1.534e-4" name="Acap" units="cm2"/>
<variable name="C" units="mF"/>
<variable initial_value="25.84e-6" name="Vmyo" units="uL"/>
<variable initial_value="0.16e-6" name="VJSR" units="uL"/>
<variable initial_value="2.1e-6" name="VNSR" units="uL"/>
<variable initial_value="1.2e-9" name="VSS" units="uL"/>
<variable initial_value="0.9798304162e1" name="Nai" public_interface="out" units="mM"/>
<variable initial_value="0.1255589432e3" name="Ki" public_interface="out" units="mM"/>
<variable initial_value="0.8601192016e-4" name="Cai" public_interface="out" units="mM"/>
<variable initial_value="0.1420215245e-3" name="CaSS" public_interface="out" units="mM"/>
<variable cmeta:id="COMPUTE_CONCENTRATION_AND_VOLTAGE_DERIVATIVES_CaJSR" initial_value="0.2852239446" name="CaJSR" public_interface="out" units="mM"/>
<variable cmeta:id="COMPUTE_CONCENTRATION_AND_VOLTAGE_DERIVATIVES_CaNSR" initial_value="0.2855294915" name="CaNSR" public_interface="out" units="mM"/>
<variable cmeta:id="COMPUTE_CONCENTRATION_AND_VOLTAGE_DERIVATIVES_V" initial_value="-0.9065755929e2" name="V" public_interface="out" units="mV"/>
<variable name="INa" public_interface="in" units="uA_per_uF"/>
<variable name="INab" public_interface="in" units="uA_per_uF"/>
<variable name="INaCa" public_interface="in" units="uA_per_uF"/>
<variable name="INaK" public_interface="in" units="uA_per_uF"/>
<variable name="IKv14_Na" public_interface="in" units="uA_per_uF"/>
<variable name="IKr" public_interface="in" units="uA_per_uF"/>
<variable name="IKs" public_interface="in" units="uA_per_uF"/>
<variable name="IK1" public_interface="in" units="uA_per_uF"/>
<variable name="ICaK" public_interface="in" units="uA_per_uF"/>
<variable name="ICa" public_interface="in" units="uA_per_uF"/>
<variable name="Ito1" public_interface="in" units="uA_per_uF"/>
<variable name="i_Stim" public_interface="in" units="uA_per_uF"/>
<variable name="IKv43" public_interface="in" units="uA_per_uF"/>
<variable name="IKv14_K" public_interface="in" units="uA_per_uF"/>
<variable name="ICab" public_interface="in" units="uA_per_uF"/>
<variable name="IpCa" public_interface="in" units="uA_per_uF"/>
<variable name="Jxfer" public_interface="in" units="mM_per_ms"/>
<variable name="Jup" public_interface="in" units="mM_per_ms"/>
<variable name="Jtrpn" public_interface="in" units="mM_per_ms"/>
<variable name="Jrel" public_interface="in" units="mM_per_ms"/>
<variable name="Jtr" public_interface="in" units="mM_per_ms"/>
<variable name="time" public_interface="in" units="ms"/>
<variable name="beta_SS" public_interface="in" units="dimensionless"/>
<variable name="beta_JSR" public_interface="in" units="dimensionless"/>
<variable name="beta_i" public_interface="in" units="dimensionless"/>
<variable name="i_tot" units="uA_per_uF"/>
<variable initial_value="4" name="Ko" public_interface="out" units="mM"/>
<variable initial_value="138" name="Nao" public_interface="out" units="mM"/>
<variable initial_value="2" name="Cao" public_interface="out" units="mM"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>RT_over_F</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>Rgas</ci>
<ci>Temp</ci>
</apply>
<ci>Faraday</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>C</ci>
<apply>
<times/>
<ci>Acap</ci>
<cn cellml:units="mF_per_cm2" type="e-notation">1.0<sep/>-3</cn>
</apply>
</apply>
<apply>
<eq/>
<ci>a1</ci>
<apply>
<divide/>
<ci>C</ci>
<apply>
<times/>
<ci>Vmyo</ci>
<ci>Faraday</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>a2</ci>
<apply>
<divide/>
<ci>C</ci>
<apply>
<times/>
<cn cellml:units="dimensionless">2</cn>
<ci>VSS</ci>
<ci>Faraday</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>Nai</ci>
</apply>
<apply>
<times/>
<apply>
<minus/>
<apply>
<plus/>
<ci>INa</ci>
<ci>INab</ci>
<apply>
<times/>
<cn cellml:units="dimensionless">3</cn>
<apply>
<plus/>
<ci>INaCa</ci>
<ci>INaK</ci>
</apply>
</apply>
<ci>IKv14_Na</ci>
</apply>
</apply>
<ci>a1</ci>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>Ki</ci>
</apply>
<apply>
<times/>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<minus/>
<apply>
<plus/>
<ci>IKr</ci>
<ci>IKs</ci>
<ci>IK1</ci>
<ci>ICaK</ci>
<ci>i_Stim</ci>
</apply>
<apply>
<times/>
<cn cellml:units="dimensionless">2</cn>
<ci>INaK</ci>
</apply>
</apply>
<ci>IKv43</ci>
<ci>IKv14_K</ci>
</apply>
</apply>
<ci>a1</ci>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>Cai</ci>
</apply>
<apply>
<times/>
<ci>beta_i</ci>
<apply>
<minus/>
<apply>
<minus/>
<apply>
<minus/>
<ci>Jxfer</ci>
<ci>Jup</ci>
</apply>
<ci>Jtrpn</ci>
</apply>
<apply>
<times/>
<apply>
<plus/>
<apply>
<minus/>
<ci>ICab</ci>
<apply>
<times/>
<cn cellml:units="dimensionless">2</cn>
<ci>INaCa</ci>
</apply>
</apply>
<ci>IpCa</ci>
</apply>
<cn cellml:units="dimensionless">0.5</cn>
<ci>a1</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>CaSS</ci>
</apply>
<apply>
<times/>
<ci>beta_SS</ci>
<apply>
<minus/>
<apply>
<minus/>
<apply>
<divide/>
<apply>
<times/>
<ci>Jrel</ci>
<ci>VJSR</ci>
</apply>
<ci>VSS</ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>Jxfer</ci>
<ci>Vmyo</ci>
</apply>
<ci>VSS</ci>
</apply>
</apply>
<apply>
<times/>
<ci>ICa</ci>
<ci>a2</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>CaJSR</ci>
</apply>
<apply>
<times/>
<ci>beta_JSR</ci>
<apply>
<minus/>
<ci>Jtr</ci>
<ci>Jrel</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>CaNSR</ci>
</apply>
<apply>
<minus/>
<apply>
<divide/>
<apply>
<times/>
<ci>Jup</ci>
<ci>Vmyo</ci>
</apply>
<ci>VNSR</ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>Jtr</ci>
<ci>VJSR</ci>
</apply>
<ci>VNSR</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>i_tot</ci>
<apply>
<plus/>
<ci>INa</ci>
<ci>ICa</ci>
<ci>ICaK</ci>
<ci>IKr</ci>
<ci>IKs</ci>
<ci>IK1</ci>
<ci>INaCa</ci>
<ci>INaK</ci>
<ci>Ito1</ci>
<ci>IpCa</ci>
<ci>ICab</ci>
<ci>INab</ci>
<ci>i_Stim</ci>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>V</ci>
</apply>
<apply>
<minus/>
<ci>i_tot</ci>
</apply>
</apply>
</math>
</component>
<component name="I_stimulus">
<variable name="i_Stim" public_interface="out" units="uA_per_uF"/>
<variable name="time" public_interface="in" units="ms"/>
<variable initial_value="1e3" name="stim_period" units="ms"/>
<variable initial_value="3" name="stim_duration" units="ms"/>
<variable initial_value="-15" name="stim_amplitude" units="uA_per_uF"/>
<variable initial_value="0" name="stim_offset" units="ms"/>
<variable name="past" units="ms"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>past</ci>
<apply>
<times/>
<apply>
<floor/>
<apply>
<divide/>
<ci>time</ci>
<ci>stim_period</ci>
</apply>
</apply>
<ci>stim_period</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>i_Stim</ci>
<piecewise>
<piece>
<ci>stim_amplitude</ci>
<apply>
<and/>
<apply>
<geq/>
<apply>
<minus/>
<ci>time</ci>
<ci>past</ci>
</apply>
<ci>stim_offset</ci>
</apply>
<apply>
<leq/>
<apply>
<minus/>
<ci>time</ci>
<ci>past</ci>
</apply>
<apply>
<plus/>
<ci>stim_offset</ci>
<ci>stim_duration</ci>
</apply>
</apply>
</apply>
</piece>
<otherwise>
<cn cellml:units="uA_per_uF">0</cn>
</otherwise>
</piecewise>
</apply>
</math>
</component>
<component name="COMPUTE_INTRACELLULAR_CALCIUM_FLUXES">
<variable name="fb" units="dimensionless"/>
<variable name="Cai" public_interface="in" units="mM"/>
<variable initial_value="0.000168" name="Kfb" units="mM"/>
<variable initial_value="1.2" name="Nfb" units="dimensionless"/>
<variable name="rb" units="dimensionless"/>
<variable name="CaNSR" public_interface="in" units="mM"/>
<variable initial_value="3.29" name="Krb" units="mM"/>
<variable initial_value="1" name="Nrb" units="dimensionless"/>
<variable cmeta:id="COMPUTE_INTRACELLULAR_CALCIUM_FLUXES_Jup" name="Jup" public_interface="out" units="mM_per_ms"/>
<variable initial_value="1.2" name="KSR" units="mM"/>
<variable initial_value="0.0748e-3" name="vmaxf" units="per_ms"/>
<variable initial_value="0.318e-3" name="vmaxr" units="per_ms"/>
<variable cmeta:id="COMPUTE_INTRACELLULAR_CALCIUM_FLUXES_Jrel" name="Jrel" public_interface="out" units="mM_per_ms"/>
<variable initial_value="1.8" name="v1" units="per_ms"/>
<variable name="O1_RyR" public_interface="in" units="dimensionless"/>
<variable name="O2_RyR" public_interface="in" units="dimensionless"/>
<variable name="CaJSR" public_interface="in" units="mM"/>
<variable name="CaSS" public_interface="in" units="mM"/>
<variable cmeta:id="COMPUTE_INTRACELLULAR_CALCIUM_FLUXES_Jtr" name="Jtr" public_interface="out" units="mM_per_ms"/>
<variable initial_value="0.5747" name="tautr" units="ms"/>
<variable cmeta:id="COMPUTE_INTRACELLULAR_CALCIUM_FLUXES_Jxfer" name="Jxfer" public_interface="out" units="mM_per_ms"/>
<variable initial_value="26.7" name="tauxfer" units="ms"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>fb</ci>
<apply>
<power/>
<apply>
<divide/>
<ci>Cai</ci>
<ci>Kfb</ci>
</apply>
<ci>Nfb</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>rb</ci>
<apply>
<power/>
<apply>
<divide/>
<ci>CaNSR</ci>
<ci>Krb</ci>
</apply>
<ci>Nrb</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>Jup</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>KSR</ci>
<apply>
<minus/>
<apply>
<times/>
<ci>vmaxf</ci>
<ci>fb</ci>
</apply>
<apply>
<times/>
<ci>vmaxr</ci>
<ci>rb</ci>
</apply>
</apply>
</apply>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<ci>fb</ci>
<ci>rb</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>Jrel</ci>
<apply>
<times/>
<ci>v1</ci>
<apply>
<plus/>
<ci>O1_RyR</ci>
<ci>O2_RyR</ci>
</apply>
<apply>
<minus/>
<ci>CaJSR</ci>
<ci>CaSS</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>Jtr</ci>
<apply>
<divide/>
<apply>
<minus/>
<ci>CaNSR</ci>
<ci>CaJSR</ci>
</apply>
<ci>tautr</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>Jxfer</ci>
<apply>
<divide/>
<apply>
<minus/>
<ci>CaSS</ci>
<ci>Cai</ci>
</apply>
<ci>tauxfer</ci>
</apply>
</apply>
</math>
</component>
<component name="COMPUTE_Jtrpn_and_BUFFER_SCALE_FACTORS">
<variable initial_value="70e-3" name="LTRPNtot" units="mM"/>
<variable initial_value="140e-3" name="HTRPNtot" units="mM"/>
<variable initial_value="20e0" name="khtrpn_plus" units="per_mM_per_ms"/>
<variable initial_value="0.066e-3" name="khtrpn_minus" units="per_ms"/>
<variable initial_value="40e0" name="kltrpn_plus" units="per_mM_per_ms"/>
<variable initial_value="40e-3" name="kltrpn_minus" units="per_ms"/>
<variable cmeta:id="COMPUTE_Jtrpn_and_BUFFER_SCALE_FACTORS_CMDNtot" initial_value="50e-3" name="CMDNtot" units="mM"/>
<variable cmeta:id="COMPUTE_Jtrpn_and_BUFFER_SCALE_FACTORS_CSQNtot" initial_value="15e0" name="CSQNtot" units="mM"/>
<variable initial_value="0e0" name="EGTAtot" units="mM"/>
<variable initial_value="2.38e-3" name="KmCMDN" units="mM"/>
<variable initial_value="0.8e0" name="KmCSQN" units="mM"/>
<variable initial_value="1.5e-4" name="KmEGTA" units="mM"/>
<variable name="Cai" public_interface="in" units="mM"/>
<variable name="dLTRPNCa" units="per_ms"/>
<variable name="dHTRPNCa" units="per_ms"/>
<variable cmeta:id="COMPUTE_Jtrpn_and_BUFFER_SCALE_FACTORS_Jtrpn" name="Jtrpn" public_interface="out" units="mM_per_ms"/>
<variable name="CaSS" public_interface="in" units="mM"/>
<variable name="beta_SS" public_interface="out" units="dimensionless"/>
<variable name="beta_JSR" public_interface="out" units="dimensionless"/>
<variable name="beta_i" public_interface="out" units="dimensionless"/>
<variable name="CaJSR" public_interface="in" units="mM"/>
<variable initial_value="0.8046584973e-1" name="LTRPNCa" public_interface="out" units="dimensionless"/>
<variable initial_value="0.9772152481" name="HTRPNCa" public_interface="out" units="dimensionless"/>
<variable name="time" public_interface="in" units="ms"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>dLTRPNCa</ci>
<apply>
<minus/>
<apply>
<times/>
<ci>kltrpn_plus</ci>
<ci>Cai</ci>
<apply>
<minus/>
<cn cellml:units="dimensionless">1</cn>
<ci>LTRPNCa</ci>
</apply>
</apply>
<apply>
<times/>
<ci>kltrpn_minus</ci>
<ci>LTRPNCa</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>dHTRPNCa</ci>
<apply>
<minus/>
<apply>
<times/>
<ci>khtrpn_plus</ci>
<ci>Cai</ci>
<apply>
<minus/>
<cn cellml:units="dimensionless">1</cn>
<ci>HTRPNCa</ci>
</apply>
</apply>
<apply>
<times/>
<ci>khtrpn_minus</ci>
<ci>HTRPNCa</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>LTRPNCa</ci>
</apply>
<ci>dLTRPNCa</ci>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>HTRPNCa</ci>
</apply>
<ci>dHTRPNCa</ci>
</apply>
<apply>
<eq/>
<ci>Jtrpn</ci>
<apply>
<plus/>
<apply>
<times/>
<ci>LTRPNtot</ci>
<ci>dLTRPNCa</ci>
</apply>
<apply>
<times/>
<ci>HTRPNtot</ci>
<ci>dHTRPNCa</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>beta_SS</ci>
<apply>
<divide/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<apply>
<times/>
<ci>CMDNtot</ci>
<ci>KmCMDN</ci>
</apply>
<apply>
<power/>
<apply>
<plus/>
<ci>CaSS</ci>
<ci>KmCMDN</ci>
</apply>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>EGTAtot</ci>
<ci>KmEGTA</ci>
</apply>
<apply>
<power/>
<apply>
<plus/>
<ci>CaSS</ci>
<ci>KmEGTA</ci>
</apply>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>beta_JSR</ci>
<apply>
<divide/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<apply>
<times/>
<ci>CSQNtot</ci>
<ci>KmCSQN</ci>
</apply>
<apply>
<power/>
<apply>
<plus/>
<ci>CaJSR</ci>
<ci>KmCSQN</ci>
</apply>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>beta_i</ci>
<apply>
<divide/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<apply>
<times/>
<ci>CMDNtot</ci>
<ci>KmCMDN</ci>
</apply>
<apply>
<power/>
<apply>
<plus/>
<ci>Cai</ci>
<ci>KmCMDN</ci>
</apply>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>EGTAtot</ci>
<ci>KmEGTA</ci>
</apply>
<apply>
<power/>
<apply>
<plus/>
<ci>Cai</ci>
<ci>KmEGTA</ci>
</apply>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="COMPUTE_DERIVATIVES_OF_RyR_RECEPTOR_STATES">
<variable initial_value="0.01215" name="kaplus" units="per_uM4_per_ms"/>
<variable initial_value="0.576" name="kaminus" units="per_ms"/>
<variable initial_value="0.00405" name="kbplus" units="per_uM3_per_ms"/>
<variable initial_value="1.93" name="kbminus" units="per_ms"/>
<variable initial_value="0.1" name="kcplus" units="per_ms"/>
<variable initial_value="0.0008" name="kcminus" units="per_ms"/>
<variable initial_value="4" name="ncoop" units="dimensionless"/>
<variable initial_value="3" name="mcoop" units="dimensionless"/>
<variable name="CaSS" public_interface="in" units="mM"/>
<variable name="dC1_RyR" units="per_ms"/>
<variable name="dO2_RyR" units="per_ms"/>
<variable name="dC2_RyR" units="per_ms"/>
<variable name="dO1_RyR" units="per_ms"/>
<variable name="time" public_interface="in" units="ms"/>
<variable initial_value="0.4448038946" name="C1_RyR" public_interface="out" units="dimensionless"/>
<variable initial_value="0.397392006e-8" name="O2_RyR" public_interface="out" units="dimensionless"/>
<variable initial_value="0.554535924" name="C2_RyR" public_interface="out" units="dimensionless"/>
<variable initial_value="0.6601783287e-3" name="O1_RyR" public_interface="out" units="dimensionless"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>dC1_RyR</ci>
<apply>
<plus/>
<apply>
<times/>
<apply>
<minus/>
<ci>kaplus</ci>
</apply>
<apply>
<power/>
<apply>
<times/>
<ci>CaSS</ci>
<cn cellml:units="m2u">1000</cn>
</apply>
<ci>ncoop</ci>
</apply>
<ci>C1_RyR</ci>
</apply>
<apply>
<times/>
<ci>kaminus</ci>
<ci>O1_RyR</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>dO2_RyR</ci>
<apply>
<minus/>
<apply>
<times/>
<ci>kbplus</ci>
<apply>
<power/>
<apply>
<times/>
<ci>CaSS</ci>
<cn cellml:units="m2u">1000</cn>
</apply>
<ci>mcoop</ci>
</apply>
<ci>O1_RyR</ci>
</apply>
<apply>
<times/>
<ci>kbminus</ci>
<ci>O2_RyR</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>dC2_RyR</ci>
<apply>
<minus/>
<apply>
<times/>
<ci>kcplus</ci>
<ci>O1_RyR</ci>
</apply>
<apply>
<times/>
<ci>kcminus</ci>
<ci>C2_RyR</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>dO1_RyR</ci>
<apply>
<minus/>
<apply>
<plus/>
<ci>dC1_RyR</ci>
<ci>dO2_RyR</ci>
<ci>dC2_RyR</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>C1_RyR</ci>
</apply>
<ci>dC1_RyR</ci>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>O2_RyR</ci>
</apply>
<ci>dO2_RyR</ci>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>C2_RyR</ci>
</apply>
<ci>dC2_RyR</ci>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>O1_RyR</ci>
</apply>
<ci>dO1_RyR</ci>
</apply>
</math>
</component>
<component name="COMPUTE_DERIVATIVES_OF_LTYPE_CHANNEL_STATES">
<variable initial_value="0.3" name="fL" units="per_ms"/>
<variable initial_value="4" name="gL" units="per_ms"/>
<variable initial_value="2" name="bL" units="dimensionless"/>
<variable initial_value="2" name="aL" units="dimensionless"/>
<variable name="C0_to_C1" units="per_ms"/>
<variable name="C1_to_C2" units="per_ms"/>
<variable name="C2_to_C3" units="per_ms"/>
<variable name="C3_to_C4" units="per_ms"/>
<variable name="C1_to_C0" units="per_ms"/>
<variable name="C2_to_C1" units="per_ms"/>
<variable name="C3_to_C2" units="per_ms"/>
<variable name="C4_to_C3" units="per_ms"/>
<variable name="CCa0_to_CCa1" units="per_ms"/>
<variable name="CCa1_to_CCa2" units="per_ms"/>
<variable name="CCa2_to_CCa3" units="per_ms"/>
<variable name="CCa3_to_CCa4" units="per_ms"/>
<variable name="CCa1_to_CCa0" units="per_ms"/>
<variable name="CCa2_to_CCa1" units="per_ms"/>
<variable name="CCa3_to_CCa2" units="per_ms"/>
<variable name="CCa4_to_CCa3" units="per_ms"/>
<variable name="C0_to_CCa0" units="per_ms"/>
<variable name="C1_to_CCa1" units="per_ms"/>
<variable name="C2_to_CCa2" units="per_ms"/>
<variable name="C3_to_CCa3" units="per_ms"/>
<variable name="C4_to_CCa4" units="per_ms"/>
<variable name="CCa0_to_C0" units="per_ms"/>
<variable name="CCa1_to_C1" units="per_ms"/>
<variable name="CCa2_to_C2" units="per_ms"/>
<variable name="CCa3_to_C3" units="per_ms"/>
<variable name="CCa4_to_C4" units="per_ms"/>
<variable name="V" public_interface="in" units="mV"/>
<variable name="alpha" units="per_ms"/>
<variable name="beta" units="per_ms"/>
<variable name="alpha_prime" units="per_ms"/>
<variable name="beta_prime" units="per_ms"/>
<variable name="gamma" units="per_ms"/>
<variable name="omega" units="per_ms"/>
<variable name="a1_Ca0" units="per_ms"/>
<variable name="a2_Ca0" units="per_ms"/>
<variable name="a1_Ca1" units="per_ms"/>
<variable name="a2_Ca1" units="per_ms"/>
<variable name="a1_Ca2" units="per_ms"/>
<variable name="a2_Ca2" units="per_ms"/>
<variable name="a1_Ca3" units="per_ms"/>
<variable name="a2_Ca3" units="per_ms"/>
<variable name="a1_Ca4" units="per_ms"/>
<variable name="a2_Ca4" units="per_ms"/>
<variable name="a1_C0" units="per_ms"/>
<variable name="a2_C0" units="per_ms"/>
<variable name="a1_C1" units="per_ms"/>
<variable name="a2_C1" units="per_ms"/>
<variable name="a1_C2" units="per_ms"/>
<variable name="a2_C2" units="per_ms"/>
<variable name="a1_C3" units="per_ms"/>
<variable name="a2_C3" units="per_ms"/>
<variable name="a1_C4" units="per_ms"/>
<variable name="a2_C4" units="per_ms"/>
<variable name="CaSS" public_interface="in" units="mM"/>
<variable initial_value="0.8621934054" name="C0" units="dimensionless"/>
<variable initial_value="0.01141398211" name="C1" units="dimensionless"/>
<variable initial_value="5.666325225e-5" name="C2" units="dimensionless"/>
<variable initial_value="1.25021357e-7" name="C3" units="dimensionless"/>
<variable initial_value="1.034426748e-10" name="C4" units="dimensionless"/>
<variable initial_value="0.1198547081" name="CCa0" units="dimensionless"/>
<variable initial_value="0.006346794302" name="CCa1" units="dimensionless"/>
<variable initial_value="1.260326488e-4" name="CCa2" units="dimensionless"/>
<variable initial_value="1.112315238e-6" name="CCa3" units="dimensionless"/>
<variable initial_value="3.681315892e-9" name="CCa4" units="dimensionless"/>
<variable name="time" public_interface="in" units="ms"/>
<variable initial_value="7.757981563e-12" name="Open" public_interface="out" units="dimensionless"/>
<variable initial_value="0.9997157074" name="yCa" public_interface="out" units="dimensionless"/>
<variable name="a1_Cainf" units="dimensionless"/>
<variable name="yCa_inf" units="dimensionless"/>
<variable name="tau_yCa" units="ms"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>alpha</ci>
<apply>
<times/>
<cn cellml:units="per_ms">4</cn>
<cn cellml:units="dimensionless">1.2</cn>
<cn cellml:units="dimensionless">0.416</cn>
<apply>
<exp/>
<apply>
<times/>
<cn cellml:units="per_mV">0.012</cn>
<apply>
<minus/>
<ci>V</ci>
<cn cellml:units="mV">35</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>beta</ci>
<apply>
<times/>
<cn cellml:units="per_ms">4</cn>
<cn cellml:units="dimensionless">0.45</cn>
<cn cellml:units="dimensionless">0.049</cn>
<apply>
<exp/>
<apply>
<times/>
<apply>
<minus/>
<cn cellml:units="per_mV">0.065</cn>
</apply>
<apply>
<minus/>
<ci>V</ci>
<cn cellml:units="mV">22</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>alpha_prime</ci>
<apply>
<times/>
<ci>aL</ci>
<ci>alpha</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>beta_prime</ci>
<apply>
<divide/>
<ci>beta</ci>
<ci>bL</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>gamma</ci>
<apply>
<times/>
<cn cellml:units="per_ms">0.6</cn>
<cn cellml:units="per_mM">0.09233</cn>
<ci>CaSS</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>omega</ci>
<apply>
<times/>
<cn cellml:units="per_ms">0.25</cn>
<cn cellml:units="dimensionless">0.01</cn>
</apply>
</apply>
<apply>
<eq/>
<ci>C0_to_C1</ci>
<apply>
<times/>
<cn cellml:units="dimensionless">4</cn>
<ci>alpha</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>C1_to_C2</ci>
<apply>
<times/>
<cn cellml:units="dimensionless">3</cn>
<ci>alpha</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>C2_to_C3</ci>
<apply>
<times/>
<cn cellml:units="dimensionless">2</cn>
<ci>alpha</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>C3_to_C4</ci>
<ci>alpha</ci>
</apply>
<apply>
<eq/>
<ci>CCa0_to_CCa1</ci>
<apply>
<times/>
<cn cellml:units="dimensionless">4</cn>
<ci>alpha_prime</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>CCa1_to_CCa2</ci>
<apply>
<times/>
<cn cellml:units="dimensionless">3</cn>
<ci>alpha_prime</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>CCa2_to_CCa3</ci>
<apply>
<times/>
<cn cellml:units="dimensionless">2</cn>
<ci>alpha_prime</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>CCa3_to_CCa4</ci>
<ci>alpha_prime</ci>
</apply>
<apply>
<eq/>
<ci>C1_to_C0</ci>
<ci>beta</ci>
</apply>
<apply>
<eq/>
<ci>C2_to_C1</ci>
<apply>
<times/>
<cn cellml:units="dimensionless">2</cn>
<ci>beta</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>C3_to_C2</ci>
<apply>
<times/>
<cn cellml:units="dimensionless">3</cn>
<ci>beta</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>C4_to_C3</ci>
<apply>
<times/>
<cn cellml:units="dimensionless">4</cn>
<ci>beta</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>CCa1_to_CCa0</ci>
<ci>beta_prime</ci>
</apply>
<apply>
<eq/>
<ci>CCa2_to_CCa1</ci>
<apply>
<times/>
<cn cellml:units="dimensionless">2</cn>
<ci>beta_prime</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>CCa3_to_CCa2</ci>
<apply>
<times/>
<cn cellml:units="dimensionless">3</cn>
<ci>beta_prime</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>CCa4_to_CCa3</ci>
<apply>
<times/>
<cn cellml:units="dimensionless">4</cn>
<ci>beta_prime</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>C0_to_CCa0</ci>
<ci>gamma</ci>
</apply>
<apply>
<eq/>
<ci>C1_to_CCa1</ci>
<apply>
<times/>
<ci>aL</ci>
<ci>C0_to_CCa0</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>C2_to_CCa2</ci>
<apply>
<times/>
<ci>aL</ci>
<ci>C1_to_CCa1</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>C3_to_CCa3</ci>
<apply>
<times/>
<ci>aL</ci>
<ci>C2_to_CCa2</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>C4_to_CCa4</ci>
<apply>
<times/>
<ci>aL</ci>
<ci>C3_to_CCa3</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>CCa0_to_C0</ci>
<ci>omega</ci>
</apply>
<apply>
<eq/>
<ci>CCa1_to_C1</ci>
<apply>
<divide/>
<ci>CCa0_to_C0</ci>
<ci>bL</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>CCa2_to_C2</ci>
<apply>
<divide/>
<ci>CCa1_to_C1</ci>
<ci>bL</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>CCa3_to_C3</ci>
<apply>
<divide/>
<ci>CCa2_to_C2</ci>
<ci>bL</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>CCa4_to_C4</ci>
<apply>
<divide/>
<ci>CCa3_to_C3</ci>
<ci>bL</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>a1_C0</ci>
<apply>
<times/>
<apply>
<plus/>
<ci>C0_to_C1</ci>
<ci>C0_to_CCa0</ci>
</apply>
<ci>C0</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>a2_C0</ci>
<apply>
<plus/>
<apply>
<times/>
<ci>C1_to_C0</ci>
<ci>C1</ci>
</apply>
<apply>
<times/>
<ci>CCa0_to_C0</ci>
<ci>CCa0</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>C0</ci>
</apply>
<apply>
<minus/>
<ci>a2_C0</ci>
<ci>a1_C0</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>a1_C1</ci>
<apply>
<times/>
<apply>
<plus/>
<ci>C1_to_C0</ci>
<ci>C1_to_C2</ci>
<ci>C1_to_CCa1</ci>
</apply>
<ci>C1</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>a2_C1</ci>
<apply>
<plus/>
<apply>
<times/>
<ci>C0_to_C1</ci>
<ci>C0</ci>
</apply>
<apply>
<times/>
<ci>C2_to_C1</ci>
<ci>C2</ci>
</apply>
<apply>
<times/>
<ci>CCa1_to_C1</ci>
<ci>CCa1</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>C1</ci>
</apply>
<apply>
<minus/>
<ci>a2_C1</ci>
<ci>a1_C1</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>a1_C2</ci>
<apply>
<times/>
<apply>
<plus/>
<ci>C2_to_C1</ci>
<ci>C2_to_C3</ci>
<ci>C2_to_CCa2</ci>
</apply>
<ci>C2</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>a2_C2</ci>
<apply>
<plus/>
<apply>
<times/>
<ci>C1_to_C2</ci>
<ci>C1</ci>
</apply>
<apply>
<times/>
<ci>C3_to_C2</ci>
<ci>C3</ci>
</apply>
<apply>
<times/>
<ci>CCa2_to_C2</ci>
<ci>CCa2</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>C2</ci>
</apply>
<apply>
<minus/>
<ci>a2_C2</ci>
<ci>a1_C2</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>a1_C3</ci>
<apply>
<times/>
<apply>
<plus/>
<ci>C3_to_C2</ci>
<ci>C3_to_C4</ci>
<ci>C3_to_CCa3</ci>
</apply>
<ci>C3</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>a2_C3</ci>
<apply>
<plus/>
<apply>
<times/>
<ci>C2_to_C3</ci>
<ci>C2</ci>
</apply>
<apply>
<times/>
<ci>C4_to_C3</ci>
<ci>C4</ci>
</apply>
<apply>
<times/>
<ci>CCa3_to_C3</ci>
<ci>CCa3</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>C3</ci>
</apply>
<apply>
<minus/>
<ci>a2_C3</ci>
<ci>a1_C3</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>a1_C4</ci>
<apply>
<times/>
<apply>
<plus/>
<ci>C4_to_C3</ci>
<ci>fL</ci>
<ci>C4_to_CCa4</ci>
</apply>
<ci>C4</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>a2_C4</ci>
<apply>
<plus/>
<apply>
<times/>
<ci>C3_to_C4</ci>
<ci>C3</ci>
</apply>
<apply>
<times/>
<ci>gL</ci>
<ci>Open</ci>
</apply>
<apply>
<times/>
<ci>CCa4_to_C4</ci>
<ci>CCa4</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>C4</ci>
</apply>
<apply>
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<ci>CI1Kv14</ci>
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<times/>
<ci>C0Kv14_to_C1Kv14</ci>
<ci>C0Kv14</ci>
</apply>
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<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
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<apply>
<minus/>
<ci>a2_C1</ci>
<ci>a1_C1</ci>
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<apply>
<eq/>
<ci>a1_C2</ci>
<apply>
<times/>
<apply>
<plus/>
<ci>C2Kv14_to_C3Kv14</ci>
<ci>C2Kv14_to_C1Kv14</ci>
<ci>C2Kv14_to_CI2Kv14</ci>
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<ci>C2Kv14</ci>
</apply>
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<apply>
<eq/>
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<apply>
<plus/>
<apply>
<times/>
<ci>C3Kv14_to_C2Kv14</ci>
<ci>C3Kv14</ci>
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<apply>
<times/>
<ci>CI2Kv14_to_C2Kv14</ci>
<ci>CI2Kv14</ci>
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<apply>
<times/>
<ci>C1Kv14_to_C2Kv14</ci>
<ci>C1Kv14</ci>
</apply>
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<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>C2Kv14</ci>
</apply>
<apply>
<minus/>
<ci>a2_C2</ci>
<ci>a1_C2</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>a1_C3</ci>
<apply>
<times/>
<apply>
<plus/>
<ci>C3Kv14_to_OKv14</ci>
<ci>C3Kv14_to_C2Kv14</ci>
<ci>C3Kv14_to_CI3Kv14</ci>
</apply>
<ci>C3Kv14</ci>
</apply>
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<apply>
<eq/>
<ci>a2_C3</ci>
<apply>
<plus/>
<apply>
<times/>
<ci>OKv14_to_C3Kv14</ci>
<ci>OKv14</ci>
</apply>
<apply>
<times/>
<ci>CI3Kv14_to_C3Kv14</ci>
<ci>CI3Kv14</ci>
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<apply>
<times/>
<ci>C2Kv14_to_C3Kv14</ci>
<ci>C2Kv14</ci>
</apply>
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<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>C3Kv14</ci>
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<apply>
<minus/>
<ci>a2_C3</ci>
<ci>a1_C3</ci>
</apply>
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<apply>
<eq/>
<ci>a1_O</ci>
<apply>
<times/>
<apply>
<plus/>
<ci>OKv14_to_C3Kv14</ci>
<ci>OKv14_to_OIKv14</ci>
</apply>
<ci>OKv14</ci>
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<apply>
<eq/>
<ci>a2_O</ci>
<apply>
<plus/>
<apply>
<times/>
<ci>C3Kv14_to_OKv14</ci>
<ci>C3Kv14</ci>
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<apply>
<times/>
<ci>OIKv14_to_OKv14</ci>
<ci>OIKv14</ci>
</apply>
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<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>OKv14</ci>
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<apply>
<minus/>
<ci>a2_O</ci>
<ci>a1_O</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>a1_CI0</ci>
<apply>
<times/>
<apply>
<plus/>
<ci>CI0Kv14_to_C0Kv14</ci>
<ci>CI0Kv14_to_CI1Kv14</ci>
</apply>
<ci>CI0Kv14</ci>
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<apply>
<eq/>
<ci>a2_CI0</ci>
<apply>
<plus/>
<apply>
<times/>
<ci>C0Kv14_to_CI0Kv14</ci>
<ci>C0Kv14</ci>
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<apply>
<times/>
<ci>CI1Kv14_to_CI0Kv14</ci>
<ci>CI1Kv14</ci>
</apply>
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<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>CI0Kv14</ci>
</apply>
<apply>
<minus/>
<ci>a2_CI0</ci>
<ci>a1_CI0</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>a1_CI1</ci>
<apply>
<times/>
<apply>
<plus/>
<ci>CI1Kv14_to_CI2Kv14</ci>
<ci>CI1Kv14_to_C1Kv14</ci>
<ci>CI1Kv14_to_CI0Kv14</ci>
</apply>
<ci>CI1Kv14</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>a2_CI1</ci>
<apply>
<plus/>
<apply>
<times/>
<ci>CI2Kv14_to_CI1Kv14</ci>
<ci>CI2Kv14</ci>
</apply>
<apply>
<times/>
<ci>C1Kv14_to_CI1Kv14</ci>
<ci>C1Kv14</ci>
</apply>
<apply>
<times/>
<ci>CI0Kv14_to_CI1Kv14</ci>
<ci>CI0Kv14</ci>
</apply>
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<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>CI1Kv14</ci>
</apply>
<apply>
<minus/>
<ci>a2_CI1</ci>
<ci>a1_CI1</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>a1_CI2</ci>
<apply>
<times/>
<apply>
<plus/>
<ci>CI2Kv14_to_CI3Kv14</ci>
<ci>CI2Kv14_to_C2Kv14</ci>
<ci>CI2Kv14_to_CI1Kv14</ci>
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<ci>CI2Kv14</ci>
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<apply>
<eq/>
<ci>a2_CI2</ci>
<apply>
<plus/>
<apply>
<times/>
<ci>CI3Kv14_to_CI2Kv14</ci>
<ci>CI3Kv14</ci>
</apply>
<apply>
<times/>
<ci>C2Kv14_to_CI2Kv14</ci>
<ci>C2Kv14</ci>
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<apply>
<times/>
<ci>CI1Kv14_to_CI2Kv14</ci>
<ci>CI1Kv14</ci>
</apply>
</apply>
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<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>CI2Kv14</ci>
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<apply>
<minus/>
<ci>a2_CI2</ci>
<ci>a1_CI2</ci>
</apply>
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<apply>
<eq/>
<ci>a1_CI3</ci>
<apply>
<times/>
<apply>
<plus/>
<ci>CI3Kv14_to_OIKv14</ci>
<ci>CI3Kv14_to_C3Kv14</ci>
<ci>CI3Kv14_to_CI2Kv14</ci>
</apply>
<ci>CI3Kv14</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>a2_CI3</ci>
<apply>
<plus/>
<apply>
<times/>
<ci>OIKv14_to_CI3Kv14</ci>
<ci>OIKv14</ci>
</apply>
<apply>
<times/>
<ci>C3Kv14_to_CI3Kv14</ci>
<ci>C3Kv14</ci>
</apply>
<apply>
<times/>
<ci>CI2Kv14_to_CI3Kv14</ci>
<ci>CI2Kv14</ci>
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<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>CI3Kv14</ci>
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<apply>
<minus/>
<ci>a2_CI3</ci>
<ci>a1_CI3</ci>
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</apply>
<apply>
<eq/>
<ci>a1_OI</ci>
<apply>
<times/>
<apply>
<plus/>
<ci>OIKv14_to_OKv14</ci>
<ci>OIKv14_to_CI3Kv14</ci>
</apply>
<ci>OIKv14</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>a2_OI</ci>
<apply>
<plus/>
<apply>
<times/>
<ci>OKv14_to_OIKv14</ci>
<ci>OKv14</ci>
</apply>
<apply>
<times/>
<ci>CI3Kv14_to_OIKv14</ci>
<ci>CI3Kv14</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>OIKv14</ci>
</apply>
<apply>
<minus/>
<ci>a2_OI</ci>
<ci>a1_OI</ci>
</apply>
</apply>
</math>
</component>
<component name="COMPUTE_REVERSAL_POTENTIALS">
<variable name="ENa" public_interface="out" units="mV"/>
<variable name="EK" public_interface="out" units="mV"/>
<variable name="EKs" public_interface="out" units="mV"/>
<variable name="ECa" public_interface="out" units="mV"/>
<variable name="RT_over_F" public_interface="in" units="mV"/>
<variable name="Nao" public_interface="in" units="mM"/>
<variable name="Nai" public_interface="in" units="mM"/>
<variable name="Ko" public_interface="in" units="mM"/>
<variable name="Ki" public_interface="in" units="mM"/>
<variable name="Cao" public_interface="in" units="mM"/>
<variable name="Cai" public_interface="in" units="mM"/>
<variable name="a1" units="mM"/>
<variable name="a2" units="mM"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>ENa</ci>
<apply>
<times/>
<ci>RT_over_F</ci>
<apply>
<ln/>
<apply>
<divide/>
<ci>Nao</ci>
<ci>Nai</ci>
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</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>EK</ci>
<apply>
<times/>
<ci>RT_over_F</ci>
<apply>
<ln/>
<apply>
<divide/>
<ci>Ko</ci>
<ci>Ki</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>a1</ci>
<apply>
<plus/>
<ci>Ko</ci>
<apply>
<times/>
<cn cellml:units="dimensionless">0.01833</cn>
<ci>Nao</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>a2</ci>
<apply>
<plus/>
<ci>Ki</ci>
<apply>
<times/>
<cn cellml:units="dimensionless">0.01833</cn>
<ci>Nai</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>EKs</ci>
<apply>
<times/>
<ci>RT_over_F</ci>
<apply>
<ln/>
<apply>
<divide/>
<ci>a1</ci>
<ci>a2</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>ECa</ci>
<apply>
<times/>
<cn cellml:units="dimensionless">0.5</cn>
<ci>RT_over_F</ci>
<apply>
<ln/>
<apply>
<divide/>
<ci>Cao</ci>
<ci>Cai</ci>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="COMPUTE_INa_IKr_IKs_Ito1_IK1_INab_IKp">
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<variable initial_value="0.0035e0" name="GKs" units="mS_per_uF"/>
<variable initial_value="0.1253051261188079722568586886469e0" name="GK1" units="mS_per_uF"/>
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<variable name="GKv43" units="mS_per_uF"/>
<variable name="PKv14" units="litre_per_farad_second"/>
<variable name="OKv14" public_interface="in" units="dimensionless"/>
<variable name="na6" public_interface="in" units="dimensionless"/>
<variable name="na7" public_interface="in" units="dimensionless"/>
<variable name="V" public_interface="in" units="mV"/>
<variable name="ENa" public_interface="in" units="mV"/>
<variable name="Ko" public_interface="in" units="mM"/>
<variable name="OHerg" public_interface="in" units="dimensionless"/>
<variable name="O1ks" public_interface="in" units="dimensionless"/>
<variable name="O2ks" public_interface="in" units="dimensionless"/>
<variable name="OKv43" public_interface="in" units="dimensionless"/>
<variable name="RT_over_F" public_interface="in" units="mV"/>
<variable name="Faraday" public_interface="in" units="coulomb_per_millimole"/>
<variable name="Ki" public_interface="in" units="mM"/>
<variable name="EK" public_interface="in" units="mV"/>
<variable name="fKo" units="dimensionless"/>
<variable name="VF_over_RT" units="dimensionless"/>
<variable name="VFsq_over_RT" units="coulomb_per_millimole"/>
<variable name="a1_K" units="mM"/>
<variable name="a2" units="dimensionless"/>
<variable name="a1_Na" units="mM"/>
<variable name="K1_inf" units="dimensionless"/>
<variable cmeta:id="COMPUTE_INa_IKr_IKs_Ito1_IK1_INab_IKp_IKr" name="IKr" public_interface="out" units="uA_per_uF"/>
<variable cmeta:id="COMPUTE_INa_IKr_IKs_Ito1_IK1_INab_IKp_IKs" name="IKs" public_interface="out" units="uA_per_uF"/>
<variable name="IKv43" public_interface="out" units="uA_per_uF"/>
<variable name="IKv14_K" public_interface="out" units="uA_per_uF"/>
<variable name="Nai" public_interface="in" units="mM"/>
<variable name="Nao" public_interface="in" units="mM"/>
<variable name="IKv14_Na" public_interface="out" units="uA_per_uF"/>
<variable name="IKv14" public_interface="out" units="uA_per_uF"/>
<variable cmeta:id="COMPUTE_INa_IKr_IKs_Ito1_IK1_INab_IKp_Ito1" name="Ito1" public_interface="out" units="uA_per_uF"/>
<variable cmeta:id="COMPUTE_INa_IKr_IKs_Ito1_IK1_INab_IKp_IK1" name="IK1" public_interface="out" units="uA_per_uF"/>
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<math xmlns="http://www.w3.org/1998/Math/MathML">
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<eq/>
<ci>PKv14</ci>
<apply>
<times/>
<apply>
<minus/>
<cn cellml:units="dimensionless">1</cn>
<ci>Kv43Frac</ci>
</apply>
<ci>KvScale</ci>
<cn cellml:units="litre_per_farad_second" type="e-notation">4.2986<sep/>-7</cn>
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</apply>
<apply>
<eq/>
<ci>GKv43</ci>
<apply>
<times/>
<ci>Kv43Frac</ci>
<ci>KvScale</ci>
<cn cellml:units="mS_per_uF">0.1</cn>
</apply>
</apply>
<apply>
<eq/>
<ci>INa</ci>
<apply>
<times/>
<ci>GNa</ci>
<apply>
<plus/>
<ci>na6</ci>
<ci>na7</ci>
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<apply>
<minus/>
<ci>V</ci>
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</apply>
<apply>
<eq/>
<ci>fKo</ci>
<apply>
<root/>
<apply>
<divide/>
<ci>Ko</ci>
<cn cellml:units="mM">4</cn>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>IKr</ci>
<apply>
<times/>
<ci>GKr</ci>
<ci>fKo</ci>
<ci>OHerg</ci>
<apply>
<minus/>
<ci>V</ci>
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<apply>
<eq/>
<ci>IKs</ci>
<apply>
<times/>
<ci>GKs</ci>
<apply>
<plus/>
<ci>O1ks</ci>
<ci>O2ks</ci>
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<apply>
<minus/>
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<apply>
<eq/>
<ci>IKv43</ci>
<apply>
<times/>
<ci>GKv43</ci>
<ci>OKv43</ci>
<apply>
<minus/>
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<apply>
<eq/>
<ci>VF_over_RT</ci>
<apply>
<divide/>
<ci>V</ci>
<ci>RT_over_F</ci>
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<apply>
<eq/>
<ci>VFsq_over_RT</ci>
<apply>
<times/>
<cn cellml:units="dimensionless">1000</cn>
<ci>Faraday</ci>
<ci>VF_over_RT</ci>
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<apply>
<eq/>
<ci>a1_K</ci>
<apply>
<minus/>
<apply>
<times/>
<ci>Ki</ci>
<apply>
<exp/>
<ci>VF_over_RT</ci>
</apply>
</apply>
<ci>Ko</ci>
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<apply>
<eq/>
<ci>a2</ci>
<apply>
<minus/>
<apply>
<exp/>
<ci>VF_over_RT</ci>
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<cn cellml:units="dimensionless">1</cn>
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<apply>
<eq/>
<ci>IKv14_K</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>PKv14</ci>
<ci>OKv14</ci>
<ci>VFsq_over_RT</ci>
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<eq/>
<ci>a1_Na</ci>
<apply>
<minus/>
<apply>
<times/>
<ci>Nai</ci>
<apply>
<exp/>
<ci>VF_over_RT</ci>
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<ci>Nao</ci>
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<apply>
<eq/>
<ci>IKv14_Na</ci>
<apply>
<divide/>
<apply>
<times/>
<cn cellml:units="dimensionless">0.02</cn>
<ci>PKv14</ci>
<ci>OKv14</ci>
<ci>VFsq_over_RT</ci>
<ci>a1_Na</ci>
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<apply>
<eq/>
<ci>IKv14</ci>
<apply>
<plus/>
<ci>IKv14_K</ci>
<ci>IKv14_Na</ci>
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<apply>
<eq/>
<ci>Ito1</ci>
<apply>
<plus/>
<ci>IKv43</ci>
<ci>IKv14</ci>
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<apply>
<eq/>
<ci>K1_inf</ci>
<apply>
<divide/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">0.94</cn>
<apply>
<exp/>
<apply>
<times/>
<apply>
<divide/>
<cn cellml:units="dimensionless">1.26</cn>
<ci>RT_over_F</ci>
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<apply>
<minus/>
<ci>V</ci>
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</apply>
</apply>
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</apply>
<apply>
<eq/>
<ci>IK1</ci>
<apply>
<times/>
<ci>GK1</ci>
<apply>
<root/>
<apply>
<divide/>
<ci>Ko</ci>
<cn cellml:units="mM">1</cn>
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</apply>
<ci>K1_inf</ci>
<apply>
<minus/>
<ci>V</ci>
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<apply>
<eq/>
<ci>INab</ci>
<apply>
<times/>
<ci>GNab</ci>
<apply>
<minus/>
<ci>V</ci>
<ci>ENa</ci>
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</apply>
</apply>
</math>
</component>
<component name="COMPUTE_INaK_INaCa_ICab_IpCa">
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<variable name="ECa" public_interface="in" units="mV"/>
<variable name="RT_over_F" public_interface="in" units="mV"/>
<variable name="Nai" public_interface="in" units="mM"/>
<variable name="Nao" public_interface="in" units="mM"/>
<variable name="Ko" public_interface="in" units="mM"/>
<variable name="Cai" public_interface="in" units="mM"/>
<variable name="Cao" public_interface="in" units="mM"/>
<variable initial_value="0.44" name="kNaCa" units="uA_per_uF"/>
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<variable initial_value="1.38" name="KmCa" units="mM"/>
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<variable initial_value="0.05" name="IpCamax" units="uA_per_uF"/>
<variable initial_value="0.0005" name="KmpCa" units="mM"/>
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<variable name="VF_over_RT" units="dimensionless"/>
<variable name="sigma" units="dimensionless"/>
<variable name="a1_Na" units="dimensionless"/>
<variable name="a2_Na" units="dimensionless"/>
<variable name="fNaK" units="dimensionless"/>
<variable name="a1_K" units="dimensionless"/>
<variable name="a2_K" units="dimensionless"/>
<variable cmeta:id="COMPUTE_INaK_INaCa_ICab_IpCa_INaK" name="INaK" public_interface="out" units="uA_per_uF"/>
<variable name="a1_ncx" units="mM4"/>
<variable name="a2_ncx" units="mM4"/>
<variable name="a3_ncx" units="dimensionless"/>
<variable name="a4_ncx" units="mM"/>
<variable name="a5_ncx" units="mM3"/>
<variable cmeta:id="COMPUTE_INaK_INaCa_ICab_IpCa_INaCa" name="INaCa" public_interface="out" units="uA_per_uF"/>
<variable cmeta:id="COMPUTE_INaK_INaCa_ICab_IpCa_ICab" name="ICab" public_interface="out" units="uA_per_uF"/>
<variable cmeta:id="COMPUTE_INaK_INaCa_ICab_IpCa_IpCa" name="IpCa" public_interface="out" units="uA_per_uF"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>ICab</ci>
<apply>
<times/>
<ci>GCab</ci>
<apply>
<minus/>
<ci>V</ci>
<ci>ECa</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>IpCa</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>IpCamax</ci>
<ci>Cai</ci>
</apply>
<apply>
<plus/>
<ci>KmpCa</ci>
<ci>Cai</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>VF_over_RT</ci>
<apply>
<divide/>
<ci>V</ci>
<ci>RT_over_F</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>sigma</ci>
<apply>
<divide/>
<apply>
<minus/>
<apply>
<exp/>
<apply>
<divide/>
<ci>Nao</ci>
<cn cellml:units="mM">67.3</cn>
</apply>
</apply>
<cn cellml:units="dimensionless">1</cn>
</apply>
<cn cellml:units="dimensionless">7</cn>
</apply>
</apply>
<apply>
<eq/>
<ci>a1_Na</ci>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<times/>
<cn cellml:units="dimensionless">0.1245</cn>
<apply>
<exp/>
<apply>
<times/>
<apply>
<minus/>
<cn cellml:units="dimensionless">0.1</cn>
</apply>
<ci>VF_over_RT</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>a2_Na</ci>
<apply>
<times/>
<cn cellml:units="dimensionless">0.0365</cn>
<ci>sigma</ci>
<apply>
<exp/>
<apply>
<times/>
<apply>
<minus/>
<cn cellml:units="dimensionless">1.33</cn>
</apply>
<ci>VF_over_RT</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>fNaK</ci>
<apply>
<divide/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<plus/>
<ci>a1_Na</ci>
<ci>a2_Na</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>a1_K</ci>
<apply>
<divide/>
<ci>Ko</ci>
<apply>
<plus/>
<ci>Ko</ci>
<ci>KmKo</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>a2_K</ci>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<power/>
<apply>
<divide/>
<ci>KmNai</ci>
<ci>Nai</ci>
</apply>
<cn cellml:units="dimensionless">1.5</cn>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>INaK</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>INaKmax</ci>
<ci>fNaK</ci>
<ci>a1_K</ci>
</apply>
<ci>a2_K</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>a1_ncx</ci>
<apply>
<times/>
<apply>
<exp/>
<apply>
<times/>
<ci>eta</ci>
<ci>VF_over_RT</ci>
</apply>
</apply>
<apply>
<power/>
<ci>Nai</ci>
<cn cellml:units="dimensionless">3</cn>
</apply>
<ci>Cao</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>a2_ncx</ci>
<apply>
<times/>
<apply>
<exp/>
<apply>
<times/>
<apply>
<minus/>
<ci>eta</ci>
<cn cellml:units="dimensionless">1</cn>
</apply>
<ci>VF_over_RT</ci>
</apply>
</apply>
<apply>
<power/>
<ci>Nao</ci>
<cn cellml:units="dimensionless">3</cn>
</apply>
<ci>Cai</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>a3_ncx</ci>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<times/>
<ci>ksat</ci>
<apply>
<exp/>
<apply>
<times/>
<apply>
<minus/>
<ci>eta</ci>
<cn cellml:units="dimensionless">1</cn>
</apply>
<ci>VF_over_RT</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>a4_ncx</ci>
<apply>
<plus/>
<ci>KmCa</ci>
<ci>Cao</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>a5_ncx</ci>
<apply>
<divide/>
<apply>
<plus/>
<apply>
<power/>
<ci>KmNa</ci>
<cn cellml:units="dimensionless">3</cn>
</apply>
<apply>
<power/>
<ci>Nao</ci>
<cn cellml:units="dimensionless">3</cn>
</apply>
</apply>
<cn cellml:units="dimensionless">5000</cn>
</apply>
</apply>
<apply>
<eq/>
<ci>INaCa</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>kNaCa</ci>
<apply>
<minus/>
<ci>a1_ncx</ci>
<ci>a2_ncx</ci>
</apply>
</apply>
<apply>
<times/>
<ci>a4_ncx</ci>
<ci>a3_ncx</ci>
<ci>a5_ncx</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="COMPUTE_ICa_ICaK">
<variable name="Ko" public_interface="in" units="mM"/>
<variable name="Ki" public_interface="in" units="mM"/>
<variable name="RT_over_F" public_interface="in" units="mV"/>
<variable name="Cai" public_interface="in" units="mM"/>
<variable name="Cao" public_interface="in" units="mM"/>
<variable name="V" public_interface="in" units="mV"/>
<variable name="yCa" public_interface="in" units="dimensionless"/>
<variable name="Open" public_interface="in" units="dimensionless"/>
<variable name="Faraday" public_interface="in" units="coulomb_per_millimole"/>
<variable name="PKprime" units="litre_per_farad_second"/>
<variable name="VF_over_RT" units="dimensionless"/>
<variable name="VFsq_over_RT" units="coulomb_per_millimole"/>
<variable name="a1_Ca" units="mM"/>
<variable name="a2_Ca" units="dimensionless"/>
<variable name="a1_K" units="mM"/>
<variable name="a2_K" units="dimensionless"/>
<variable name="ICa" public_interface="out" units="uA_per_uF"/>
<variable name="ICaK" public_interface="out" units="uA_per_uF"/>
<variable name="ICamax" units="uA_per_uF"/>
<variable name="Icabar" units="uA_per_uF"/>
<variable name="PCa" units="litre_per_farad_second"/>
<variable name="PK" units="litre_per_farad_second"/>
<variable initial_value="-0.265" name="ICahalf" units="uA_per_uF"/>
<variable initial_value="7" name="Pscale" units="dimensionless"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>PK</ci>
<apply>
<times/>
<ci>Pscale</ci>
<cn cellml:units="litre_per_farad_second" type="e-notation">4.574<sep/>-7</cn>
</apply>
</apply>
<apply>
<eq/>
<ci>PCa</ci>
<apply>
<times/>
<ci>Pscale</ci>
<cn cellml:units="litre_per_farad_second" type="e-notation">2.469<sep/>-4</cn>
</apply>
</apply>
<apply>
<eq/>
<ci>VF_over_RT</ci>
<apply>
<divide/>
<ci>V</ci>
<ci>RT_over_F</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>VFsq_over_RT</ci>
<apply>
<times/>
<cn cellml:units="dimensionless">1000</cn>
<ci>Faraday</ci>
<ci>VF_over_RT</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>a1_Ca</ci>
<apply>
<minus/>
<apply>
<times/>
<cn cellml:units="mM" type="e-notation">1.0<sep/>-3</cn>
<apply>
<exp/>
<apply>
<times/>
<cn cellml:units="dimensionless">2</cn>
<ci>VF_over_RT</ci>
</apply>
</apply>
</apply>
<apply>
<times/>
<ci>Cao</ci>
<cn cellml:units="dimensionless">0.341</cn>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>a2_Ca</ci>
<apply>
<minus/>
<apply>
<exp/>
<apply>
<times/>
<cn cellml:units="dimensionless">2</cn>
<ci>VF_over_RT</ci>
</apply>
</apply>
<cn cellml:units="dimensionless">1</cn>
</apply>
</apply>
<apply>
<eq/>
<ci>ICamax</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>PCa</ci>
<cn cellml:units="dimensionless">4</cn>
<ci>VFsq_over_RT</ci>
<ci>a1_Ca</ci>
</apply>
<ci>a2_Ca</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>ICa</ci>
<apply>
<times/>
<ci>ICamax</ci>
<ci>yCa</ci>
<ci>Open</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>Icabar</ci>
<piecewise>
<piece>
<cn cellml:units="uA_per_uF">0</cn>
<apply>
<geq/>
<ci>ICamax</ci>
<cn cellml:units="uA_per_uF">0</cn>
</apply>
</piece>
<otherwise>
<ci>ICamax</ci>
</otherwise>
</piecewise>
</apply>
<apply>
<eq/>
<ci>PKprime</ci>
<apply>
<divide/>
<ci>PK</ci>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>Icabar</ci>
<ci>ICahalf</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>a1_K</ci>
<apply>
<minus/>
<apply>
<times/>
<ci>Ki</ci>
<apply>
<exp/>
<ci>VF_over_RT</ci>
</apply>
</apply>
<ci>Ko</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>a2_K</ci>
<apply>
<minus/>
<apply>
<exp/>
<ci>VF_over_RT</ci>
</apply>
<cn cellml:units="dimensionless">1</cn>
</apply>
</apply>
<apply>
<eq/>
<ci>ICaK</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>PKprime</ci>
<ci>Open</ci>
<ci>yCa</ci>
<ci>VFsq_over_RT</ci>
<ci>a1_K</ci>
</apply>
<ci>a2_K</ci>
</apply>
</apply>
</math>
</component>
<component name="INa">
<variable name="V" public_interface="in" units="mV"/>
<variable name="time" public_interface="in" units="ms"/>
<variable name="Temp_Scale" units="dimensionless"/>
<variable name="alpha1" units="per_ms"/>
<variable name="beta1" units="per_ms"/>
<variable name="gamma1" units="per_ms"/>
<variable name="Delta1" units="per_ms"/>
<variable name="On" units="per_ms"/>
<variable name="Of" units="per_ms"/>
<variable name="GammaGamma" units="per_ms"/>
<variable name="DeltaDelta" units="per_ms"/>
<variable name="epsilon" units="per_ms"/>
<variable name="omega_na" units="per_ms"/>
<variable name="rho" units="per_ms"/>
<variable name="mu" units="per_ms"/>
<variable name="Cn" units="per_ms"/>
<variable name="Cf" units="per_ms"/>
<variable name="parameter_a" units="dimensionless"/>
<variable name="k12" units="per_ms"/>
<variable name="k23" units="per_ms"/>
<variable name="k34" units="per_ms"/>
<variable name="k45" units="per_ms"/>
<variable name="k56" units="per_ms"/>
<variable name="k67" units="per_ms"/>
<variable name="k89" units="per_ms"/>
<variable name="k910" units="per_ms"/>
<variable name="k1011" units="per_ms"/>
<variable name="k1112" units="per_ms"/>
<variable name="k1213" units="per_ms"/>
<variable name="k57" units="per_ms"/>
<variable name="k21" units="per_ms"/>
<variable name="k32" units="per_ms"/>
<variable name="k43" units="per_ms"/>
<variable name="k54" units="per_ms"/>
<variable name="k65" units="per_ms"/>
<variable name="k76" units="per_ms"/>
<variable name="k98" units="per_ms"/>
<variable name="k109" units="per_ms"/>
<variable name="k1110" units="per_ms"/>
<variable name="k1211" units="per_ms"/>
<variable name="k1312" units="per_ms"/>
<variable name="k75" units="per_ms"/>
<variable name="k81" units="per_ms"/>
<variable name="k92" units="per_ms"/>
<variable name="k103" units="per_ms"/>
<variable name="k114" units="per_ms"/>
<variable name="k125" units="per_ms"/>
<variable name="k136" units="per_ms"/>
<variable name="k18" units="per_ms"/>
<variable name="k29" units="per_ms"/>
<variable name="k310" units="per_ms"/>
<variable name="k411" units="per_ms"/>
<variable name="k512" units="per_ms"/>
<variable name="k613" units="per_ms"/>
<variable initial_value="0.1437575649" name="na1" public_interface="out" units="dimensionless"/>
<variable initial_value="0.0417776208" name="na2" public_interface="out" units="dimensionless"/>
<variable initial_value="0.004552898364" name="na3" public_interface="out" units="dimensionless"/>
<variable initial_value="2.20520743e-4" name="na4" public_interface="out" units="dimensionless"/>
<variable initial_value="4.005266484e-6" name="na5" public_interface="out" units="dimensionless"/>
<variable initial_value="1.57442749e-8" name="na6" public_interface="out" units="dimensionless"/>
<variable initial_value="2.856607179e-9" name="na7" public_interface="out" units="dimensionless"/>
<variable initial_value="0.4749950008" name="na8" public_interface="out" units="dimensionless"/>
<variable initial_value="0.2707214097" name="na9" public_interface="out" units="dimensionless"/>
<variable initial_value="0.05786120057" name="na10" public_interface="out" units="dimensionless"/>
<variable initial_value="0.005496292279" name="na11" public_interface="out" units="dimensionless"/>
<variable initial_value="1.957874519e-4" name="na12" public_interface="out" units="dimensionless"/>
<variable initial_value="4.17679396e-4" name="na13" public_interface="out" units="dimensionless"/>
<variable initial_value="294.16" name="TNa" units="kelvin"/>
<variable name="KToverH" units="per_ms"/>
<variable name="FoverRT" units="per_mV"/>
<variable name="RToverF" public_interface="in" units="mV"/>
<variable name="RTNa" units="joule_per_mole"/>
<variable name="RTNaF" units="mV"/>
<variable name="Faraday" public_interface="in" units="coulomb_per_millimole"/>
<variable name="Rgas" public_interface="in" units="joule_per_mole_kelvin"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>FoverRT</ci>
<apply>
<divide/>
<cn cellml:units="dimensionless">1</cn>
<ci>RToverF</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>KToverH</ci>
<apply>
<divide/>
<apply>
<times/>
<cn cellml:units="joule_per_kelvin" type="e-notation">1.381<sep/>-23</cn>
<ci>TNa</ci>
</apply>
<cn cellml:units="joule_ms" type="e-notation">6.626<sep/>-31</cn>
</apply>
</apply>
<apply>
<eq/>
<ci>RTNa</ci>
<apply>
<times/>
<ci>Rgas</ci>
<ci>TNa</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>RTNaF</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>Rgas</ci>
<ci>TNa</ci>
</apply>
<ci>Faraday</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>Temp_Scale</ci>
<cn cellml:units="dimensionless">1.38862291252871</cn>
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<apply>
<eq/>
<ci>alpha1</ci>
<apply>
<times/>
<ci>Temp_Scale</ci>
<ci>KToverH</ci>
<apply>
<exp/>
<apply>
<plus/>
<apply>
<divide/>
<apply>
<minus/>
<cn cellml:units="joule_per_mole">114007.462700232</cn>
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<ci>RTNa</ci>
</apply>
<apply>
<divide/>
<cn cellml:units="joule_per_mole_kelvin">224.114</cn>
<ci>Rgas</ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<cn cellml:units="dimensionless">0.286374268596235</cn>
<ci>V</ci>
</apply>
<ci>RTNaF</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>beta1</ci>
<apply>
<times/>
<ci>Temp_Scale</ci>
<ci>KToverH</ci>
<apply>
<exp/>
<apply>
<plus/>
<apply>
<divide/>
<apply>
<minus/>
<cn cellml:units="joule_per_mole">272470.273489681</cn>
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<ci>RTNa</ci>
</apply>
<apply>
<divide/>
<cn cellml:units="joule_per_mole_kelvin">708.146</cn>
<ci>Rgas</ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<apply>
<minus/>
<cn cellml:units="dimensionless">2.28528417586424</cn>
</apply>
<ci>V</ci>
</apply>
<ci>RTNaF</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>gamma1</ci>
<apply>
<times/>
<ci>Temp_Scale</ci>
<ci>KToverH</ci>
<apply>
<exp/>
<apply>
<plus/>
<apply>
<divide/>
<apply>
<minus/>
<cn cellml:units="joule_per_mole">196336.575735923</cn>
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<ci>RTNa</ci>
</apply>
<apply>
<divide/>
<cn cellml:units="joule_per_mole_kelvin">529.952</cn>
<ci>Rgas</ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<cn cellml:units="dimensionless">2.78084918596045</cn>
<ci>V</ci>
</apply>
<ci>RTNaF</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>Delta1</ci>
<apply>
<times/>
<ci>Temp_Scale</ci>
<ci>KToverH</ci>
<apply>
<exp/>
<apply>
<plus/>
<apply>
<divide/>
<apply>
<minus/>
<cn cellml:units="joule_per_mole">133689.9304091</cn>
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<ci>RTNa</ci>
</apply>
<apply>
<divide/>
<cn cellml:units="joule_per_mole_kelvin">229.205</cn>
<ci>Rgas</ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<apply>
<minus/>
<cn cellml:units="dimensionless">1.55804214553883</cn>
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<ci>V</ci>
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<ci>RTNaF</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>On</ci>
<apply>
<times/>
<ci>Temp_Scale</ci>
<ci>KToverH</ci>
<apply>
<exp/>
<apply>
<plus/>
<apply>
<divide/>
<apply>
<minus/>
<cn cellml:units="joule_per_mole">62123.0784380481</cn>
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<ci>RTNa</ci>
</apply>
<apply>
<divide/>
<cn cellml:units="joule_per_mole_kelvin">39.295</cn>
<ci>Rgas</ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<cn cellml:units="dimensionless">0.288816042743232</cn>
<ci>V</ci>
</apply>
<ci>RTNaF</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>Of</ci>
<apply>
<times/>
<ci>Temp_Scale</ci>
<ci>KToverH</ci>
<apply>
<exp/>
<apply>
<plus/>
<apply>
<divide/>
<apply>
<minus/>
<cn cellml:units="joule_per_mole">97657.8497137015</cn>
</apply>
<ci>RTNa</ci>
</apply>
<apply>
<divide/>
<cn cellml:units="joule_per_mole_kelvin">1.51</cn>
<ci>Rgas</ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<cn cellml:units="dimensionless">0.0684861993100685</cn>
<ci>V</ci>
</apply>
<ci>RTNaF</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>GammaGamma</ci>
<apply>
<times/>
<ci>Temp_Scale</ci>
<ci>KToverH</ci>
<apply>
<exp/>
<apply>
<plus/>
<apply>
<divide/>
<cn cellml:units="joule_per_mole">116431.142142348</cn>
<ci>RTNa</ci>
</apply>
<apply>
<divide/>
<apply>
<minus/>
<cn cellml:units="joule_per_mole_kelvin">578.317</cn>
</apply>
<ci>Rgas</ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<cn cellml:units="dimensionless">0.764126011745707</cn>
<ci>V</ci>
</apply>
<ci>RTNaF</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>DeltaDelta</ci>
<apply>
<times/>
<ci>Temp_Scale</ci>
<ci>KToverH</ci>
<apply>
<exp/>
<apply>
<plus/>
<apply>
<divide/>
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<cn cellml:units="per_ms">0.14832978132145</cn>
</apply>
</apply>
<apply>
<eq/>
<ci>C1H_to_C2H</ci>
<apply>
<times/>
<ci>T_Const_HERG</ci>
<ci>A0_HERG</ci>
<apply>
<exp/>
<apply>
<times/>
<ci>B0_HERG</ci>
<ci>V</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>C2H_to_C1H</ci>
<apply>
<times/>
<ci>T_Const_HERG</ci>
<ci>A1_HERG</ci>
<apply>
<exp/>
<apply>
<times/>
<ci>B1_HERG</ci>
<ci>V</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>C3H_to_OH</ci>
<apply>
<times/>
<ci>T_Const_HERG</ci>
<ci>A2_HERG</ci>
<apply>
<exp/>
<apply>
<times/>
<ci>B2_HERG</ci>
<ci>V</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>OH_to_C3H</ci>
<apply>
<times/>
<ci>T_Const_HERG</ci>
<ci>A3_HERG</ci>
<apply>
<exp/>
<apply>
<times/>
<ci>B3_HERG</ci>
<ci>V</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>OH_to_IH</ci>
<apply>
<times/>
<ci>T_Const_HERG</ci>
<ci>A4_HERG</ci>
<apply>
<exp/>
<apply>
<times/>
<ci>B4_HERG</ci>
<ci>V</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>IH_to_OH</ci>
<apply>
<times/>
<ci>T_Const_HERG</ci>
<ci>A5_HERG</ci>
<apply>
<exp/>
<apply>
<times/>
<ci>B5_HERG</ci>
<ci>V</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>C3H_to_IH</ci>
<apply>
<times/>
<ci>T_Const_HERG</ci>
<ci>A6_HERG</ci>
<apply>
<exp/>
<apply>
<times/>
<ci>B6_HERG</ci>
<ci>V</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>IH_to_C3H</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>OH_to_C3H</ci>
<ci>IH_to_OH</ci>
<ci>C3H_to_IH</ci>
</apply>
<apply>
<times/>
<ci>C3H_to_OH</ci>
<ci>OH_to_IH</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>C1Herg</ci>
</apply>
<apply>
<minus/>
<apply>
<times/>
<ci>C2H_to_C1H</ci>
<ci>C2Herg</ci>
</apply>
<apply>
<times/>
<ci>C1H_to_C2H</ci>
<ci>C1Herg</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>a1_C2</ci>
<apply>
<plus/>
<apply>
<times/>
<ci>C1H_to_C2H</ci>
<ci>C1Herg</ci>
</apply>
<apply>
<times/>
<ci>C3H_to_C2H</ci>
<ci>C3Herg</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>a2_C2</ci>
<apply>
<times/>
<apply>
<plus/>
<ci>C2H_to_C1H</ci>
<ci>C2H_to_C3H</ci>
</apply>
<ci>C2Herg</ci>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>C2Herg</ci>
</apply>
<apply>
<minus/>
<ci>a1_C2</ci>
<ci>a2_C2</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>a1_C3</ci>
<apply>
<plus/>
<apply>
<times/>
<ci>C2H_to_C3H</ci>
<ci>C2Herg</ci>
</apply>
<apply>
<times/>
<ci>OH_to_C3H</ci>
<ci>OHerg</ci>
</apply>
<apply>
<times/>
<ci>IH_to_C3H</ci>
<ci>IHerg</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>a2_C3</ci>
<apply>
<times/>
<apply>
<plus/>
<ci>C3H_to_IH</ci>
<ci>C3H_to_OH</ci>
<ci>C3H_to_C2H</ci>
</apply>
<ci>C3Herg</ci>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>C3Herg</ci>
</apply>
<apply>
<minus/>
<ci>a1_C3</ci>
<ci>a2_C3</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>a1_O</ci>
<apply>
<plus/>
<apply>
<times/>
<ci>C3H_to_OH</ci>
<ci>C3Herg</ci>
</apply>
<apply>
<times/>
<ci>IH_to_OH</ci>
<ci>IHerg</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>a2_O</ci>
<apply>
<times/>
<apply>
<plus/>
<ci>OH_to_C3H</ci>
<ci>OH_to_IH</ci>
</apply>
<ci>OHerg</ci>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>OHerg</ci>
</apply>
<apply>
<minus/>
<ci>a1_O</ci>
<ci>a2_O</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>a1_I</ci>
<apply>
<plus/>
<apply>
<times/>
<ci>C3H_to_IH</ci>
<ci>C3Herg</ci>
</apply>
<apply>
<times/>
<ci>OH_to_IH</ci>
<ci>OHerg</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>a2_I</ci>
<apply>
<times/>
<apply>
<plus/>
<ci>IH_to_C3H</ci>
<ci>IH_to_OH</ci>
</apply>
<ci>IHerg</ci>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>IHerg</ci>
</apply>
<apply>
<minus/>
<ci>a1_I</ci>
<ci>a2_I</ci>
</apply>
</apply>
</math>
</component>
<component name="IKs">
<variable name="C0ks_C1ks" units="per_ms"/>
<variable name="C1ks_O1ks" units="per_ms"/>
<variable name="O1ks_O2ks" units="per_ms"/>
<variable name="O1ks_C1ks" units="per_ms"/>
<variable name="O2ks_O1ks" units="per_ms"/>
<variable name="C1ks_C0ks" units="per_ms"/>
<variable initial_value="0.9645606295" name="C0ks" public_interface="out" units="dimensionless"/>
<variable initial_value="0.03542613568" name="C1ks" public_interface="out" units="dimensionless"/>
<variable initial_value="2.491710696e-7" name="O1ks" public_interface="out" units="dimensionless"/>
<variable initial_value="1.298547822e-5" name="O2ks" public_interface="out" units="dimensionless"/>
<variable name="V" public_interface="in" units="mV"/>
<variable name="time" public_interface="in" units="ms"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>C0ks_C1ks</ci>
<cn cellml:units="per_ms">0.00795600798004</cn>
</apply>
<apply>
<eq/>
<ci>C1ks_O1ks</ci>
<cn cellml:units="per_ms">0.03966720676071</cn>
</apply>
<apply>
<eq/>
<ci>O1ks_O2ks</ci>
<apply>
<times/>
<cn cellml:units="per_ms">0.00767254363063</cn>
<apply>
<exp/>
<apply>
<times/>
<cn cellml:units="per_mV">0.08662945914655</cn>
<ci>V</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>O1ks_C1ks</ci>
<apply>
<times/>
<cn cellml:units="per_ms">0.00700806628929</cn>
<apply>
<exp/>
<apply>
<times/>
<apply>
<minus/>
<cn cellml:units="per_mV">0.14999754700285</cn>
</apply>
<ci>V</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>O2ks_O1ks</ci>
<apply>
<times/>
<cn cellml:units="per_ms">0.00379737998368</cn>
<apply>
<exp/>
<apply>
<times/>
<apply>
<minus/>
<cn cellml:units="per_mV">0.01425668126881</cn>
</apply>
<ci>V</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>C1ks_C0ks</ci>
<apply>
<times/>
<cn cellml:units="per_ms">0.2162557589585</cn>
<apply>
<exp/>
<apply>
<times/>
<apply>
<minus/>
<cn cellml:units="per_mV">0.00001889123021</cn>
</apply>
<ci>V</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>C0ks</ci>
</apply>
<apply>
<plus/>
<apply>
<times/>
<apply>
<minus/>
<ci>C0ks_C1ks</ci>
</apply>
<ci>C0ks</ci>
</apply>
<apply>
<times/>
<ci>C1ks_C0ks</ci>
<ci>C1ks</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>C1ks</ci>
</apply>
<apply>
<plus/>
<apply>
<minus/>
<apply>
<times/>
<ci>C0ks_C1ks</ci>
<ci>C0ks</ci>
</apply>
<apply>
<times/>
<apply>
<plus/>
<ci>C1ks_C0ks</ci>
<ci>C1ks_O1ks</ci>
</apply>
<ci>C1ks</ci>
</apply>
</apply>
<apply>
<times/>
<ci>O1ks_C1ks</ci>
<ci>O1ks</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>O1ks</ci>
</apply>
<apply>
<plus/>
<apply>
<minus/>
<apply>
<times/>
<ci>C1ks_O1ks</ci>
<ci>C1ks</ci>
</apply>
<apply>
<times/>
<apply>
<plus/>
<ci>O1ks_C1ks</ci>
<ci>O1ks_O2ks</ci>
</apply>
<ci>O1ks</ci>
</apply>
</apply>
<apply>
<times/>
<ci>O2ks_O1ks</ci>
<ci>O2ks</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>O2ks</ci>
</apply>
<apply>
<minus/>
<apply>
<times/>
<ci>O1ks_O2ks</ci>
<ci>O1ks</ci>
</apply>
<apply>
<times/>
<ci>O2ks_O1ks</ci>
<ci>O2ks</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="cell"/>
<component name="transmembrane_currents"/>
<component name="intracellular_currents"/>
<component name="Ions_n_reversal_potentials"/>
<connection>
<map_components component_1="environment" component_2="IKs"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="environment" component_2="COMPUTE_CONCENTRATION_AND_VOLTAGE_DERIVATIVES"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="environment" component_2="IKr"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="environment" component_2="INa"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="environment" component_2="COMPUTE_DERIVATIVES_OF_Kv1_4_CHANNEL_STATES"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="environment" component_2="COMPUTE_DERIVATIVES_OF_Kv4_3_CHANNEL_STATES"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="environment" component_2="COMPUTE_DERIVATIVES_OF_LTYPE_CHANNEL_STATES"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="environment" component_2="COMPUTE_DERIVATIVES_OF_RyR_RECEPTOR_STATES"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="environment" component_2="COMPUTE_Jtrpn_and_BUFFER_SCALE_FACTORS"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="environment" component_2="I_stimulus"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="COMPUTE_CONCENTRATION_AND_VOLTAGE_DERIVATIVES" component_2="IKs"/>
<map_variables variable_1="V" variable_2="V"/>
</connection>
<connection>
<map_components component_1="COMPUTE_CONCENTRATION_AND_VOLTAGE_DERIVATIVES" component_2="IKr"/>
<map_variables variable_1="V" variable_2="V"/>
</connection>
<connection>
<map_components component_1="COMPUTE_CONCENTRATION_AND_VOLTAGE_DERIVATIVES" component_2="INa"/>
<map_variables variable_1="V" variable_2="V"/>
<map_variables variable_1="RT_over_F" variable_2="RToverF"/>
<map_variables variable_1="Faraday" variable_2="Faraday"/>
<map_variables variable_1="Rgas" variable_2="Rgas"/>
</connection>
<connection>
<map_components component_1="COMPUTE_CONCENTRATION_AND_VOLTAGE_DERIVATIVES" component_2="COMPUTE_DERIVATIVES_OF_Kv1_4_CHANNEL_STATES"/>
<map_variables variable_1="V" variable_2="V"/>
</connection>
<connection>
<map_components component_1="COMPUTE_CONCENTRATION_AND_VOLTAGE_DERIVATIVES" component_2="COMPUTE_DERIVATIVES_OF_Kv4_3_CHANNEL_STATES"/>
<map_variables variable_1="V" variable_2="V"/>
</connection>
<connection>
<map_components component_1="COMPUTE_CONCENTRATION_AND_VOLTAGE_DERIVATIVES" component_2="COMPUTE_DERIVATIVES_OF_LTYPE_CHANNEL_STATES"/>
<map_variables variable_1="V" variable_2="V"/>
<map_variables variable_1="CaSS" variable_2="CaSS"/>
</connection>
<connection>
<map_components component_1="COMPUTE_CONCENTRATION_AND_VOLTAGE_DERIVATIVES" component_2="COMPUTE_INaK_INaCa_ICab_IpCa"/>
<map_variables variable_1="V" variable_2="V"/>
<map_variables variable_1="INaCa" variable_2="INaCa"/>
<map_variables variable_1="INaK" variable_2="INaK"/>
<map_variables variable_1="ICab" variable_2="ICab"/>
<map_variables variable_1="IpCa" variable_2="IpCa"/>
<map_variables variable_1="RT_over_F" variable_2="RT_over_F"/>
<map_variables variable_1="Nai" variable_2="Nai"/>
<map_variables variable_1="Nao" variable_2="Nao"/>
<map_variables variable_1="Ko" variable_2="Ko"/>
<map_variables variable_1="Cai" variable_2="Cai"/>
<map_variables variable_1="Cao" variable_2="Cao"/>
</connection>
<connection>
<map_components component_1="COMPUTE_REVERSAL_POTENTIALS" component_2="COMPUTE_INaK_INaCa_ICab_IpCa"/>
<map_variables variable_1="ECa" variable_2="ECa"/>
</connection>
<connection>
<map_components component_1="COMPUTE_CONCENTRATION_AND_VOLTAGE_DERIVATIVES" component_2="COMPUTE_INa_IKr_IKs_Ito1_IK1_INab_IKp"/>
<map_variables variable_1="V" variable_2="V"/>
<map_variables variable_1="INa" variable_2="INa"/>
<map_variables variable_1="INab" variable_2="INab"/>
<map_variables variable_1="IKr" variable_2="IKr"/>
<map_variables variable_1="IKv14_Na" variable_2="IKv14_Na"/>
<map_variables variable_1="IKs" variable_2="IKs"/>
<map_variables variable_1="IK1" variable_2="IK1"/>
<map_variables variable_1="Ito1" variable_2="Ito1"/>
<map_variables variable_1="IKv43" variable_2="IKv43"/>
<map_variables variable_1="IKv14_K" variable_2="IKv14_K"/>
<map_variables variable_1="Ko" variable_2="Ko"/>
<map_variables variable_1="Ki" variable_2="Ki"/>
<map_variables variable_1="Nao" variable_2="Nao"/>
<map_variables variable_1="Nai" variable_2="Nai"/>
<map_variables variable_1="RT_over_F" variable_2="RT_over_F"/>
<map_variables variable_1="Faraday" variable_2="Faraday"/>
</connection>
<connection>
<map_components component_1="COMPUTE_CONCENTRATION_AND_VOLTAGE_DERIVATIVES" component_2="COMPUTE_ICa_ICaK"/>
<map_variables variable_1="V" variable_2="V"/>
<map_variables variable_1="ICaK" variable_2="ICaK"/>
<map_variables variable_1="ICa" variable_2="ICa"/>
<map_variables variable_1="Faraday" variable_2="Faraday"/>
<map_variables variable_1="Ko" variable_2="Ko"/>
<map_variables variable_1="Ki" variable_2="Ki"/>
<map_variables variable_1="RT_over_F" variable_2="RT_over_F"/>
<map_variables variable_1="Cai" variable_2="Cai"/>
<map_variables variable_1="Cao" variable_2="Cao"/>
</connection>
<connection>
<map_components component_1="COMPUTE_CONCENTRATION_AND_VOLTAGE_DERIVATIVES" component_2="COMPUTE_DERIVATIVES_OF_RyR_RECEPTOR_STATES"/>
<map_variables variable_1="CaSS" variable_2="CaSS"/>
</connection>
<connection>
<map_components component_1="COMPUTE_CONCENTRATION_AND_VOLTAGE_DERIVATIVES" component_2="COMPUTE_Jtrpn_and_BUFFER_SCALE_FACTORS"/>
<map_variables variable_1="Cai" variable_2="Cai"/>
<map_variables variable_1="CaJSR" variable_2="CaJSR"/>
<map_variables variable_1="CaSS" variable_2="CaSS"/>
<map_variables variable_1="beta_SS" variable_2="beta_SS"/>
<map_variables variable_1="beta_JSR" variable_2="beta_JSR"/>
<map_variables variable_1="beta_i" variable_2="beta_i"/>
<map_variables variable_1="Jtrpn" variable_2="Jtrpn"/>
</connection>
<connection>
<map_components component_1="COMPUTE_CONCENTRATION_AND_VOLTAGE_DERIVATIVES" component_2="COMPUTE_INTRACELLULAR_CALCIUM_FLUXES"/>
<map_variables variable_1="Cai" variable_2="Cai"/>
<map_variables variable_1="CaNSR" variable_2="CaNSR"/>
<map_variables variable_1="CaJSR" variable_2="CaJSR"/>
<map_variables variable_1="CaSS" variable_2="CaSS"/>
<map_variables variable_1="Jxfer" variable_2="Jxfer"/>
<map_variables variable_1="Jup" variable_2="Jup"/>
<map_variables variable_1="Jrel" variable_2="Jrel"/>
<map_variables variable_1="Jtr" variable_2="Jtr"/>
</connection>
<connection>
<map_components component_1="COMPUTE_DERIVATIVES_OF_RyR_RECEPTOR_STATES" component_2="COMPUTE_INTRACELLULAR_CALCIUM_FLUXES"/>
<map_variables variable_1="O1_RyR" variable_2="O1_RyR"/>
<map_variables variable_1="O2_RyR" variable_2="O2_RyR"/>
</connection>
<connection>
<map_components component_1="COMPUTE_CONCENTRATION_AND_VOLTAGE_DERIVATIVES" component_2="I_stimulus"/>
<map_variables variable_1="i_Stim" variable_2="i_Stim"/>
</connection>
<connection>
<map_components component_1="COMPUTE_CONCENTRATION_AND_VOLTAGE_DERIVATIVES" component_2="COMPUTE_REVERSAL_POTENTIALS"/>
<map_variables variable_1="RT_over_F" variable_2="RT_over_F"/>
<map_variables variable_1="Nai" variable_2="Nai"/>
<map_variables variable_1="Ki" variable_2="Ki"/>
<map_variables variable_1="Cai" variable_2="Cai"/>
<map_variables variable_1="Nao" variable_2="Nao"/>
<map_variables variable_1="Ko" variable_2="Ko"/>
<map_variables variable_1="Cao" variable_2="Cao"/>
</connection>
<connection>
<map_components component_1="COMPUTE_INa_IKr_IKs_Ito1_IK1_INab_IKp" component_2="INa"/>
<map_variables variable_1="na6" variable_2="na6"/>
<map_variables variable_1="na7" variable_2="na7"/>
</connection>
<connection>
<map_components component_1="COMPUTE_INa_IKr_IKs_Ito1_IK1_INab_IKp" component_2="COMPUTE_DERIVATIVES_OF_Kv1_4_CHANNEL_STATES"/>
<map_variables variable_1="OKv14" variable_2="OKv14"/>
</connection>
<connection>
<map_components component_1="COMPUTE_INa_IKr_IKs_Ito1_IK1_INab_IKp" component_2="COMPUTE_REVERSAL_POTENTIALS"/>
<map_variables variable_1="ENa" variable_2="ENa"/>
<map_variables variable_1="EK" variable_2="EK"/>
</connection>
<connection>
<map_components component_1="COMPUTE_INa_IKr_IKs_Ito1_IK1_INab_IKp" component_2="IKr"/>
<map_variables variable_1="OHerg" variable_2="OHerg"/>
</connection>
<connection>
<map_components component_1="COMPUTE_INa_IKr_IKs_Ito1_IK1_INab_IKp" component_2="IKs"/>
<map_variables variable_1="O2ks" variable_2="O2ks"/>
<map_variables variable_1="O1ks" variable_2="O1ks"/>
</connection>
<connection>
<map_components component_1="COMPUTE_INa_IKr_IKs_Ito1_IK1_INab_IKp" component_2="COMPUTE_DERIVATIVES_OF_Kv4_3_CHANNEL_STATES"/>
<map_variables variable_1="OKv43" variable_2="OKv43"/>
</connection>
<connection>
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<title xmlns="http://cellml.org/tmp-documentation">A computational model of the human left-ventricular epicardial myocyte</title>
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<firstname xmlns="http://cellml.org/tmp-documentation">Steven</firstname>
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<title xmlns="http://cellml.org/tmp-documentation">Model Status</title>
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This CellML model runs in OpenCell and COR to reproduce the published results. The units have been checked and they are consistent.
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ABSTRACT: A computational model of the human left-ventricular epicardial myocyte is presented. Models of each of the major ionic currents present in these cells are formulated and validated using experimental data obtained from studies of recombinant human ion channels and/or whole-cell recording from single myocytes isolated from human left-ventricular subepicardium. Continuous-time Markov chain models for the gating of the fast Na(+) current, transient outward current, rapid component of the delayed rectifier current, and the L-type calcium current are modified to represent human data at physiological temperature. A new model for the gating of the slow component of the delayed rectifier current is formulated and validated against experimental data. Properties of calcium handling and exchanger currents are altered to appropriately represent the dynamics of intracellular ion concentrations. The model is able to both reproduce and predict a wide range of behaviors observed experimentally including action potential morphology, ionic currents, intracellular calcium transients, frequency dependence of action-potential duration, Ca(2+)-frequency relations, and extrasystolic restitution/post-extrasystolic potentiation. The model therefore serves as a useful tool for investigating mechanisms of arrhythmia and consequences of drug-channel interactions in the human left-ventricular myocyte.
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The original paper reference is cited below:
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A computational model of the human left-ventricular epicardial myocyte, Vivek Iyer, Reza Mazhari and Raimond L. Winslow, 2004, <emphasis xmlns="http://cellml.org/tmp-documentation">Biophysical Journal</emphasis>, 87, 1507-1525. <ulink xmlns="http://cellml.org/tmp-documentation" url="http://www.ncbi.nlm.nih.gov/pubmed/15345532">PubMed ID: 15345532</ulink>
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<caption xmlns="http://cellml.org/tmp-documentation">A schematic diagram describing the ion movement across the cell surface membrane and the sarcoplasmic reticulum, which are described by the Iyer <emphasis xmlns="http://cellml.org/tmp-documentation">et al.</emphasis> 2004 mathematical model of the human left-ventricular epicardial myocyte.</caption>
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<rdf:value xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xml:lang="en" xmlns:xml="http://www.w3.org/XML/1998/namespace">This file is a CellML description of Iyer et al's model of the human left ventricular epicardial myocyte as described in the paper "A Computational model of the human left-ventricular epicardial myocyte"</rdf:value>
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<W3CDTF xmlns="http://purl.org/dc/terms/" xml:lang="en" xmlns:xml="http://www.w3.org/XML/1998/namespace">2004-09-00 00:00</W3CDTF>
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<title xmlns="http://purl.org/dc/elements/1.1/" xml:lang="en" xmlns:xml="http://www.w3.org/XML/1998/namespace">Biophysical Journal</title>
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<FN xmlns="http://www.w3.org/2001/vcard-rdf/3.0#" xml:lang="en" xmlns:xml="http://www.w3.org/XML/1998/namespace">James Lawson</FN>
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