Rendering of the source text

<?xml version='1.0'?>
<!--
This CellML file was generated on 11/12/2007 at 15:38:26 using:

COR (0.9.31.833)
Copyright 2002-2007 Dr Alan Garny
http://COR.physiol.ox.ac.uk/ - COR@physiol.ox.ac.uk

CellML 1.0 was used to generate this cellular model
http://www.CellML.org/
-->
<model cmeta:id="iyer_2004" name="iyer_2004" xmlns="http://www.cellml.org/cellml/1.0#" xmlns:cellml="http://www.cellml.org/cellml/1.0#" xmlns:cmeta="http://www.cellml.org/metadata/1.0#">
    <units name="m2u">
        <unit prefix="micro" units="second"/>
        <unit exponent="-1" prefix="milli" units="second"/>
    </units>
    <units name="ms">
        <unit prefix="milli" units="second"/>
    </units>
    <units name="per_ms">
        <unit exponent="-1" units="ms"/>
    </units>
    <units name="micrometer">
        <unit prefix="micro" units="metre"/>
    </units>
    <units name="L">
        <unit units="litre"/>
    </units>
    <units name="uL">
        <unit prefix="micro" units="litre"/>
    </units>
    <units name="N_per_mm2">
        <unit units="newton"/>
        <unit exponent="-2" prefix="milli" units="metre"/>
    </units>
    <units name="mm">
        <unit prefix="milli" units="meter"/>
    </units>
    <units name="cm">
        <unit prefix="centi" units="meter"/>
    </units>
    <units name="cm_per_s">
        <unit units="cm"/>
        <unit exponent="-1" units="second"/>
    </units>
    <units name="mm3">
        <unit exponent="3" units="mm"/>
    </units>
    <units name="mm2">
        <unit exponent="2" units="mm"/>
    </units>
    <units name="cm2">
        <unit exponent="2" units="cm"/>
    </units>
    <units name="mV">
        <unit prefix="milli" units="volt"/>
    </units>
    <units name="per_mV">
        <unit exponent="-1" prefix="milli" units="volt"/>
    </units>
    <units name="mS">
        <unit prefix="milli" units="siemens"/>
    </units>
    <units name="uF">
        <unit prefix="micro" units="farad"/>
    </units>
    <units name="uA_per_uF">
        <unit units="uA"/>
        <unit exponent="-1" units="uF"/>
    </units>
    <units name="mS_per_uF">
        <unit units="mS"/>
        <unit exponent="-1" units="uF"/>
    </units>
    <units name="pF">
        <unit prefix="pico" units="farad"/>
    </units>
    <units name="mF">
        <unit prefix="milli" units="farad"/>
    </units>
    <units name="mF_per_cm2">
        <unit prefix="milli" units="farad"/>
        <unit exponent="-1" units="cm2"/>
    </units>
    <units name="uF_per_mm2">
        <unit prefix="micro" units="farad"/>
        <unit exponent="-1" units="mm2"/>
    </units>
    <units name="F_M_per_coulomb">
        <unit units="farad"/>
        <unit units="molar"/>
        <unit exponent="-1" units="coulomb"/>
    </units>
    <units name="uA">
        <unit prefix="micro" units="ampere"/>
    </units>
    <units name="molar">
        <unit units="mole"/>
        <unit exponent="-1" units="litre"/>
    </units>
    <units name="mM">
        <unit prefix="milli" units="mole"/>
        <unit exponent="-1" units="litre"/>
    </units>
    <units name="uM">
        <unit prefix="micro" units="mole"/>
        <unit exponent="-1" units="litre"/>
    </units>
    <units name="mM_per_ms">
        <unit units="mM"/>
        <unit exponent="-1" units="ms"/>
    </units>
    <units name="per_mM">
        <unit exponent="-1" units="mM"/>
    </units>
    <units name="mM3">
        <unit exponent="3" units="mM"/>
    </units>
    <units name="mM4">
        <unit exponent="4" units="mM"/>
    </units>
    <units name="per_uM3_per_ms">
        <unit exponent="-3" units="uM"/>
        <unit exponent="-1" units="ms"/>
    </units>
    <units name="per_uM4_per_ms">
        <unit exponent="-4" units="uM"/>
        <unit exponent="-1" units="ms"/>
    </units>
    <units name="litre_per_farad_second">
        <unit units="litre"/>
        <unit exponent="-1" units="farad"/>
        <unit exponent="-1" units="second"/>
    </units>
    <units name="joule_per_mole_kelvin">
        <unit units="joule"/>
        <unit exponent="-1" units="mole"/>
        <unit exponent="-1" units="kelvin"/>
    </units>
    <units name="joule_per_kelvin">
        <unit units="joule"/>
        <unit exponent="-1" units="kelvin"/>
    </units>
    <units name="joule_ms">
        <unit units="joule"/>
        <unit units="ms"/>
    </units>
    <units name="joule_per_mole">
        <unit units="joule"/>
        <unit exponent="-1" units="mole"/>
    </units>
    <units name="coulomb_per_millimole">
        <unit units="coulomb"/>
        <unit exponent="-1" prefix="milli" units="mole"/>
    </units>
    <units name="per_mM_per_ms">
        <unit exponent="-1" units="mM"/>
        <unit exponent="-1" units="ms"/>
    </units>
    <component name="environment">
        <variable cmeta:id="environment_time" name="time" public_interface="out" units="ms"/>
    </component>
    <component name="COMPUTE_CONCENTRATION_AND_VOLTAGE_DERIVATIVES">
        <variable name="a1" units="F_M_per_coulomb"/>
        <variable name="a2" units="F_M_per_coulomb"/>
        <variable initial_value="96.5" name="Faraday" public_interface="out" units="coulomb_per_millimole"/>
        <variable initial_value="310" name="Temp" units="kelvin"/>
        <variable initial_value="8.315" name="Rgas" public_interface="out" units="joule_per_mole_kelvin"/>
        <variable name="RT_over_F" public_interface="out" units="mV"/>
        <variable initial_value="1.534e-4" name="Acap" units="cm2"/>
        <variable name="C" units="mF"/>
        <variable initial_value="25.84e-6" name="Vmyo" units="uL"/>
        <variable initial_value="0.16e-6" name="VJSR" units="uL"/>
        <variable initial_value="2.1e-6" name="VNSR" units="uL"/>
        <variable initial_value="1.2e-9" name="VSS" units="uL"/>
        <variable initial_value="0.9798304162e1" name="Nai" public_interface="out" units="mM"/>
        <variable initial_value="0.1255589432e3" name="Ki" public_interface="out" units="mM"/>
        <variable initial_value="0.8601192016e-4" name="Cai" public_interface="out" units="mM"/>
        <variable initial_value="0.1420215245e-3" name="CaSS" public_interface="out" units="mM"/>
        <variable cmeta:id="COMPUTE_CONCENTRATION_AND_VOLTAGE_DERIVATIVES_CaJSR" initial_value="0.2852239446" name="CaJSR" public_interface="out" units="mM"/>
        <variable cmeta:id="COMPUTE_CONCENTRATION_AND_VOLTAGE_DERIVATIVES_CaNSR" initial_value="0.2855294915" name="CaNSR" public_interface="out" units="mM"/>
        <variable cmeta:id="COMPUTE_CONCENTRATION_AND_VOLTAGE_DERIVATIVES_V" initial_value="-0.9065755929e2" name="V" public_interface="out" units="mV"/>
        <variable name="INa" public_interface="in" units="uA_per_uF"/>
        <variable name="INab" public_interface="in" units="uA_per_uF"/>
        <variable name="INaCa" public_interface="in" units="uA_per_uF"/>
        <variable name="INaK" public_interface="in" units="uA_per_uF"/>
        <variable name="IKv14_Na" public_interface="in" units="uA_per_uF"/>
        <variable name="IKr" public_interface="in" units="uA_per_uF"/>
        <variable name="IKs" public_interface="in" units="uA_per_uF"/>
        <variable name="IK1" public_interface="in" units="uA_per_uF"/>
        <variable name="ICaK" public_interface="in" units="uA_per_uF"/>
        <variable name="ICa" public_interface="in" units="uA_per_uF"/>
        <variable name="Ito1" public_interface="in" units="uA_per_uF"/>
        <variable name="i_Stim" public_interface="in" units="uA_per_uF"/>
        <variable name="IKv43" public_interface="in" units="uA_per_uF"/>
        <variable name="IKv14_K" public_interface="in" units="uA_per_uF"/>
        <variable name="ICab" public_interface="in" units="uA_per_uF"/>
        <variable name="IpCa" public_interface="in" units="uA_per_uF"/>
        <variable name="Jxfer" public_interface="in" units="mM_per_ms"/>
        <variable name="Jup" public_interface="in" units="mM_per_ms"/>
        <variable name="Jtrpn" public_interface="in" units="mM_per_ms"/>
        <variable name="Jrel" public_interface="in" units="mM_per_ms"/>
        <variable name="Jtr" public_interface="in" units="mM_per_ms"/>
        <variable name="time" public_interface="in" units="ms"/>
        <variable name="beta_SS" public_interface="in" units="dimensionless"/>
        <variable name="beta_JSR" public_interface="in" units="dimensionless"/>
        <variable name="beta_i" public_interface="in" units="dimensionless"/>
        <variable name="i_tot" units="uA_per_uF"/>
        <variable initial_value="4" name="Ko" public_interface="out" units="mM"/>
        <variable initial_value="138" name="Nao" public_interface="out" units="mM"/>
        <variable initial_value="2" name="Cao" public_interface="out" units="mM"/>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
                <eq/>
                <ci>RT_over_F</ci>
                <apply>
                    <divide/>
                    <apply>
                        <times/>
                        <ci>Rgas</ci>
                        <ci>Temp</ci>
                    </apply>
                    <ci>Faraday</ci>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>C</ci>
                <apply>
                    <times/>
                    <ci>Acap</ci>
                    <cn cellml:units="mF_per_cm2" type="e-notation">1.0<sep/>-3</cn>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>a1</ci>
                <apply>
                    <divide/>
                    <ci>C</ci>
                    <apply>
                        <times/>
                        <ci>Vmyo</ci>
                        <ci>Faraday</ci>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>a2</ci>
                <apply>
                    <divide/>
                    <ci>C</ci>
                    <apply>
                        <times/>
                        <cn cellml:units="dimensionless">2</cn>
                        <ci>VSS</ci>
                        <ci>Faraday</ci>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <apply>
                    <diff/>
                    <bvar>
                        <ci>time</ci>
                    </bvar>
                    <ci>Nai</ci>
                </apply>
                <apply>
                    <times/>
                    <apply>
                        <minus/>
                        <apply>
                            <plus/>
                            <ci>INa</ci>
                            <ci>INab</ci>
                            <apply>
                                <times/>
                                <cn cellml:units="dimensionless">3</cn>
                                <apply>
                                    <plus/>
                                    <ci>INaCa</ci>
                                    <ci>INaK</ci>
                                </apply>
                            </apply>
                            <ci>IKv14_Na</ci>
                        </apply>
                    </apply>
                    <ci>a1</ci>
                </apply>
            </apply>
            <apply>
                <eq/>
                <apply>
                    <diff/>
                    <bvar>
                        <ci>time</ci>
                    </bvar>
                    <ci>Ki</ci>
                </apply>
                <apply>
                    <times/>
                    <apply>
                        <minus/>
                        <apply>
                            <plus/>
                            <apply>
                                <minus/>
                                <apply>
                                    <plus/>
                                    <ci>IKr</ci>
                                    <ci>IKs</ci>
                                    <ci>IK1</ci>
                                    <ci>ICaK</ci>
                                    <ci>i_Stim</ci>
                                </apply>
                                <apply>
                                    <times/>
                                    <cn cellml:units="dimensionless">2</cn>
                                    <ci>INaK</ci>
                                </apply>
                            </apply>
                            <ci>IKv43</ci>
                            <ci>IKv14_K</ci>
                        </apply>
                    </apply>
                    <ci>a1</ci>
                </apply>
            </apply>
            <apply>
                <eq/>
                <apply>
                    <diff/>
                    <bvar>
                        <ci>time</ci>
                    </bvar>
                    <ci>Cai</ci>
                </apply>
                <apply>
                    <times/>
                    <ci>beta_i</ci>
                    <apply>
                        <minus/>
                        <apply>
                            <minus/>
                            <apply>
                                <minus/>
                                <ci>Jxfer</ci>
                                <ci>Jup</ci>
                            </apply>
                            <ci>Jtrpn</ci>
                        </apply>
                        <apply>
                            <times/>
                            <apply>
                                <plus/>
                                <apply>
                                    <minus/>
                                    <ci>ICab</ci>
                                    <apply>
                                        <times/>
                                        <cn cellml:units="dimensionless">2</cn>
                                        <ci>INaCa</ci>
                                    </apply>
                                </apply>
                                <ci>IpCa</ci>
                            </apply>
                            <cn cellml:units="dimensionless">0.5</cn>
                            <ci>a1</ci>
                        </apply>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <apply>
                    <diff/>
                    <bvar>
                        <ci>time</ci>
                    </bvar>
                    <ci>CaSS</ci>
                </apply>
                <apply>
                    <times/>
                    <ci>beta_SS</ci>
                    <apply>
                        <minus/>
                        <apply>
                            <minus/>
                            <apply>
                                <divide/>
                                <apply>
                                    <times/>
                                    <ci>Jrel</ci>
                                    <ci>VJSR</ci>
                                </apply>
                                <ci>VSS</ci>
                            </apply>
                            <apply>
                                <divide/>
                                <apply>
                                    <times/>
                                    <ci>Jxfer</ci>
                                    <ci>Vmyo</ci>
                                </apply>
                                <ci>VSS</ci>
                            </apply>
                        </apply>
                        <apply>
                            <times/>
                            <ci>ICa</ci>
                            <ci>a2</ci>
                        </apply>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <apply>
                    <diff/>
                    <bvar>
                        <ci>time</ci>
                    </bvar>
                    <ci>CaJSR</ci>
                </apply>
                <apply>
                    <times/>
                    <ci>beta_JSR</ci>
                    <apply>
                        <minus/>
                        <ci>Jtr</ci>
                        <ci>Jrel</ci>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <apply>
                    <diff/>
                    <bvar>
                        <ci>time</ci>
                    </bvar>
                    <ci>CaNSR</ci>
                </apply>
                <apply>
                    <minus/>
                    <apply>
                        <divide/>
                        <apply>
                            <times/>
                            <ci>Jup</ci>
                            <ci>Vmyo</ci>
                        </apply>
                        <ci>VNSR</ci>
                    </apply>
                    <apply>
                        <divide/>
                        <apply>
                            <times/>
                            <ci>Jtr</ci>
                            <ci>VJSR</ci>
                        </apply>
                        <ci>VNSR</ci>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>i_tot</ci>
                <apply>
                    <plus/>
                    <ci>INa</ci>
                    <ci>ICa</ci>
                    <ci>ICaK</ci>
                    <ci>IKr</ci>
                    <ci>IKs</ci>
                    <ci>IK1</ci>
                    <ci>INaCa</ci>
                    <ci>INaK</ci>
                    <ci>Ito1</ci>
                    <ci>IpCa</ci>
                    <ci>ICab</ci>
                    <ci>INab</ci>
                    <ci>i_Stim</ci>
                </apply>
            </apply>
            <apply>
                <eq/>
                <apply>
                    <diff/>
                    <bvar>
                        <ci>time</ci>
                    </bvar>
                    <ci>V</ci>
                </apply>
                <apply>
                    <minus/>
                    <ci>i_tot</ci>
                </apply>
            </apply>
        </math>
    </component>
    <component name="I_stimulus">
        <variable name="i_Stim" public_interface="out" units="uA_per_uF"/>
        <variable name="time" public_interface="in" units="ms"/>
        <variable initial_value="1e3" name="stim_period" units="ms"/>
        <variable initial_value="3" name="stim_duration" units="ms"/>
        <variable initial_value="-15" name="stim_amplitude" units="uA_per_uF"/>
        <variable initial_value="0" name="stim_offset" units="ms"/>
        <variable name="past" units="ms"/>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
                <eq/>
                <ci>past</ci>
                <apply>
                    <times/>
                    <apply>
                        <floor/>
                        <apply>
                            <divide/>
                            <ci>time</ci>
                            <ci>stim_period</ci>
                        </apply>
                    </apply>
                    <ci>stim_period</ci>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>i_Stim</ci>
                <piecewise>
                    <piece>
                        <ci>stim_amplitude</ci>
                        <apply>
                            <and/>
                            <apply>
                                <geq/>
                                <apply>
                                    <minus/>
                                    <ci>time</ci>
                                    <ci>past</ci>
                                </apply>
                                <ci>stim_offset</ci>
                            </apply>
                            <apply>
                                <leq/>
                                <apply>
                                    <minus/>
                                    <ci>time</ci>
                                    <ci>past</ci>
                                </apply>
                                <apply>
                                    <plus/>
                                    <ci>stim_offset</ci>
                                    <ci>stim_duration</ci>
                                </apply>
                            </apply>
                        </apply>
                    </piece>
                    <otherwise>
                        <cn cellml:units="uA_per_uF">0</cn>
                    </otherwise>
                </piecewise>
            </apply>
        </math>
    </component>
    <component name="COMPUTE_INTRACELLULAR_CALCIUM_FLUXES">
        <variable name="fb" units="dimensionless"/>
        <variable name="Cai" public_interface="in" units="mM"/>
        <variable initial_value="0.000168" name="Kfb" units="mM"/>
        <variable initial_value="1.2" name="Nfb" units="dimensionless"/>
        <variable name="rb" units="dimensionless"/>
        <variable name="CaNSR" public_interface="in" units="mM"/>
        <variable initial_value="3.29" name="Krb" units="mM"/>
        <variable initial_value="1" name="Nrb" units="dimensionless"/>
        <variable cmeta:id="COMPUTE_INTRACELLULAR_CALCIUM_FLUXES_Jup" name="Jup" public_interface="out" units="mM_per_ms"/>
        <variable initial_value="1.2" name="KSR" units="mM"/>
        <variable initial_value="0.0748e-3" name="vmaxf" units="per_ms"/>
        <variable initial_value="0.318e-3" name="vmaxr" units="per_ms"/>
        <variable cmeta:id="COMPUTE_INTRACELLULAR_CALCIUM_FLUXES_Jrel" name="Jrel" public_interface="out" units="mM_per_ms"/>
        <variable initial_value="1.8" name="v1" units="per_ms"/>
        <variable name="O1_RyR" public_interface="in" units="dimensionless"/>
        <variable name="O2_RyR" public_interface="in" units="dimensionless"/>
        <variable name="CaJSR" public_interface="in" units="mM"/>
        <variable name="CaSS" public_interface="in" units="mM"/>
        <variable cmeta:id="COMPUTE_INTRACELLULAR_CALCIUM_FLUXES_Jtr" name="Jtr" public_interface="out" units="mM_per_ms"/>
        <variable initial_value="0.5747" name="tautr" units="ms"/>
        <variable cmeta:id="COMPUTE_INTRACELLULAR_CALCIUM_FLUXES_Jxfer" name="Jxfer" public_interface="out" units="mM_per_ms"/>
        <variable initial_value="26.7" name="tauxfer" units="ms"/>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
                <eq/>
                <ci>fb</ci>
                <apply>
                    <power/>
                    <apply>
                        <divide/>
                        <ci>Cai</ci>
                        <ci>Kfb</ci>
                    </apply>
                    <ci>Nfb</ci>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>rb</ci>
                <apply>
                    <power/>
                    <apply>
                        <divide/>
                        <ci>CaNSR</ci>
                        <ci>Krb</ci>
                    </apply>
                    <ci>Nrb</ci>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>Jup</ci>
                <apply>
                    <divide/>
                    <apply>
                        <times/>
                        <ci>KSR</ci>
                        <apply>
                            <minus/>
                            <apply>
                                <times/>
                                <ci>vmaxf</ci>
                                <ci>fb</ci>
                            </apply>
                            <apply>
                                <times/>
                                <ci>vmaxr</ci>
                                <ci>rb</ci>
                            </apply>
                        </apply>
                    </apply>
                    <apply>
                        <plus/>
                        <cn cellml:units="dimensionless">1</cn>
                        <ci>fb</ci>
                        <ci>rb</ci>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>Jrel</ci>
                <apply>
                    <times/>
                    <ci>v1</ci>
                    <apply>
                        <plus/>
                        <ci>O1_RyR</ci>
                        <ci>O2_RyR</ci>
                    </apply>
                    <apply>
                        <minus/>
                        <ci>CaJSR</ci>
                        <ci>CaSS</ci>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>Jtr</ci>
                <apply>
                    <divide/>
                    <apply>
                        <minus/>
                        <ci>CaNSR</ci>
                        <ci>CaJSR</ci>
                    </apply>
                    <ci>tautr</ci>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>Jxfer</ci>
                <apply>
                    <divide/>
                    <apply>
                        <minus/>
                        <ci>CaSS</ci>
                        <ci>Cai</ci>
                    </apply>
                    <ci>tauxfer</ci>
                </apply>
            </apply>
        </math>
    </component>
    <component name="COMPUTE_Jtrpn_and_BUFFER_SCALE_FACTORS">
        <variable initial_value="70e-3" name="LTRPNtot" units="mM"/>
        <variable initial_value="140e-3" name="HTRPNtot" units="mM"/>
        <variable initial_value="20e0" name="khtrpn_plus" units="per_mM_per_ms"/>
        <variable initial_value="0.066e-3" name="khtrpn_minus" units="per_ms"/>
        <variable initial_value="40e0" name="kltrpn_plus" units="per_mM_per_ms"/>
        <variable initial_value="40e-3" name="kltrpn_minus" units="per_ms"/>
        <variable cmeta:id="COMPUTE_Jtrpn_and_BUFFER_SCALE_FACTORS_CMDNtot" initial_value="50e-3" name="CMDNtot" units="mM"/>
        <variable cmeta:id="COMPUTE_Jtrpn_and_BUFFER_SCALE_FACTORS_CSQNtot" initial_value="15e0" name="CSQNtot" units="mM"/>
        <variable initial_value="0e0" name="EGTAtot" units="mM"/>
        <variable initial_value="2.38e-3" name="KmCMDN" units="mM"/>
        <variable initial_value="0.8e0" name="KmCSQN" units="mM"/>
        <variable initial_value="1.5e-4" name="KmEGTA" units="mM"/>
        <variable name="Cai" public_interface="in" units="mM"/>
        <variable name="dLTRPNCa" units="per_ms"/>
        <variable name="dHTRPNCa" units="per_ms"/>
        <variable cmeta:id="COMPUTE_Jtrpn_and_BUFFER_SCALE_FACTORS_Jtrpn" name="Jtrpn" public_interface="out" units="mM_per_ms"/>
        <variable name="CaSS" public_interface="in" units="mM"/>
        <variable name="beta_SS" public_interface="out" units="dimensionless"/>
        <variable name="beta_JSR" public_interface="out" units="dimensionless"/>
        <variable name="beta_i" public_interface="out" units="dimensionless"/>
        <variable name="CaJSR" public_interface="in" units="mM"/>
        <variable initial_value="0.8046584973e-1" name="LTRPNCa" public_interface="out" units="dimensionless"/>
        <variable initial_value="0.9772152481" name="HTRPNCa" public_interface="out" units="dimensionless"/>
        <variable name="time" public_interface="in" units="ms"/>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
                <eq/>
                <ci>dLTRPNCa</ci>
                <apply>
                    <minus/>
                    <apply>
                        <times/>
                        <ci>kltrpn_plus</ci>
                        <ci>Cai</ci>
                        <apply>
                            <minus/>
                            <cn cellml:units="dimensionless">1</cn>
                            <ci>LTRPNCa</ci>
                        </apply>
                    </apply>
                    <apply>
                        <times/>
                        <ci>kltrpn_minus</ci>
                        <ci>LTRPNCa</ci>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>dHTRPNCa</ci>
                <apply>
                    <minus/>
                    <apply>
                        <times/>
                        <ci>khtrpn_plus</ci>
                        <ci>Cai</ci>
                        <apply>
                            <minus/>
                            <cn cellml:units="dimensionless">1</cn>
                            <ci>HTRPNCa</ci>
                        </apply>
                    </apply>
                    <apply>
                        <times/>
                        <ci>khtrpn_minus</ci>
                        <ci>HTRPNCa</ci>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <apply>
                    <diff/>
                    <bvar>
                        <ci>time</ci>
                    </bvar>
                    <ci>LTRPNCa</ci>
                </apply>
                <ci>dLTRPNCa</ci>
            </apply>
            <apply>
                <eq/>
                <apply>
                    <diff/>
                    <bvar>
                        <ci>time</ci>
                    </bvar>
                    <ci>HTRPNCa</ci>
                </apply>
                <ci>dHTRPNCa</ci>
            </apply>
            <apply>
                <eq/>
                <ci>Jtrpn</ci>
                <apply>
                    <plus/>
                    <apply>
                        <times/>
                        <ci>LTRPNtot</ci>
                        <ci>dLTRPNCa</ci>
                    </apply>
                    <apply>
                        <times/>
                        <ci>HTRPNtot</ci>
                        <ci>dHTRPNCa</ci>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>beta_SS</ci>
                <apply>
                    <divide/>
                    <cn cellml:units="dimensionless">1</cn>
                    <apply>
                        <plus/>
                        <cn cellml:units="dimensionless">1</cn>
                        <apply>
                            <divide/>
                            <apply>
                                <times/>
                                <ci>CMDNtot</ci>
                                <ci>KmCMDN</ci>
                            </apply>
                            <apply>
                                <power/>
                                <apply>
                                    <plus/>
                                    <ci>CaSS</ci>
                                    <ci>KmCMDN</ci>
                                </apply>
                                <cn cellml:units="dimensionless">2</cn>
                            </apply>
                        </apply>
                        <apply>
                            <divide/>
                            <apply>
                                <times/>
                                <ci>EGTAtot</ci>
                                <ci>KmEGTA</ci>
                            </apply>
                            <apply>
                                <power/>
                                <apply>
                                    <plus/>
                                    <ci>CaSS</ci>
                                    <ci>KmEGTA</ci>
                                </apply>
                                <cn cellml:units="dimensionless">2</cn>
                            </apply>
                        </apply>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>beta_JSR</ci>
                <apply>
                    <divide/>
                    <cn cellml:units="dimensionless">1</cn>
                    <apply>
                        <plus/>
                        <cn cellml:units="dimensionless">1</cn>
                        <apply>
                            <divide/>
                            <apply>
                                <times/>
                                <ci>CSQNtot</ci>
                                <ci>KmCSQN</ci>
                            </apply>
                            <apply>
                                <power/>
                                <apply>
                                    <plus/>
                                    <ci>CaJSR</ci>
                                    <ci>KmCSQN</ci>
                                </apply>
                                <cn cellml:units="dimensionless">2</cn>
                            </apply>
                        </apply>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>beta_i</ci>
                <apply>
                    <divide/>
                    <cn cellml:units="dimensionless">1</cn>
                    <apply>
                        <plus/>
                        <cn cellml:units="dimensionless">1</cn>
                        <apply>
                            <divide/>
                            <apply>
                                <times/>
                                <ci>CMDNtot</ci>
                                <ci>KmCMDN</ci>
                            </apply>
                            <apply>
                                <power/>
                                <apply>
                                    <plus/>
                                    <ci>Cai</ci>
                                    <ci>KmCMDN</ci>
                                </apply>
                                <cn cellml:units="dimensionless">2</cn>
                            </apply>
                        </apply>
                        <apply>
                            <divide/>
                            <apply>
                                <times/>
                                <ci>EGTAtot</ci>
                                <ci>KmEGTA</ci>
                            </apply>
                            <apply>
                                <power/>
                                <apply>
                                    <plus/>
                                    <ci>Cai</ci>
                                    <ci>KmEGTA</ci>
                                </apply>
                                <cn cellml:units="dimensionless">2</cn>
                            </apply>
                        </apply>
                    </apply>
                </apply>
            </apply>
        </math>
    </component>
    <component name="COMPUTE_DERIVATIVES_OF_RyR_RECEPTOR_STATES">
        <variable initial_value="0.01215" name="kaplus" units="per_uM4_per_ms"/>
        <variable initial_value="0.576" name="kaminus" units="per_ms"/>
        <variable initial_value="0.00405" name="kbplus" units="per_uM3_per_ms"/>
        <variable initial_value="1.93" name="kbminus" units="per_ms"/>
        <variable initial_value="0.1" name="kcplus" units="per_ms"/>
        <variable initial_value="0.0008" name="kcminus" units="per_ms"/>
        <variable initial_value="4" name="ncoop" units="dimensionless"/>
        <variable initial_value="3" name="mcoop" units="dimensionless"/>
        <variable name="CaSS" public_interface="in" units="mM"/>
        <variable name="dC1_RyR" units="per_ms"/>
        <variable name="dO2_RyR" units="per_ms"/>
        <variable name="dC2_RyR" units="per_ms"/>
        <variable name="dO1_RyR" units="per_ms"/>
        <variable name="time" public_interface="in" units="ms"/>
        <variable initial_value="0.4448038946" name="C1_RyR" public_interface="out" units="dimensionless"/>
        <variable initial_value="0.397392006e-8" name="O2_RyR" public_interface="out" units="dimensionless"/>
        <variable initial_value="0.554535924" name="C2_RyR" public_interface="out" units="dimensionless"/>
        <variable initial_value="0.6601783287e-3" name="O1_RyR" public_interface="out" units="dimensionless"/>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
                <eq/>
                <ci>dC1_RyR</ci>
                <apply>
                    <plus/>
                    <apply>
                        <times/>
                        <apply>
                            <minus/>
                            <ci>kaplus</ci>
                        </apply>
                        <apply>
                            <power/>
                            <apply>
                                <times/>
                                <ci>CaSS</ci>
                                <cn cellml:units="m2u">1000</cn>
                            </apply>
                            <ci>ncoop</ci>
                        </apply>
                        <ci>C1_RyR</ci>
                    </apply>
                    <apply>
                        <times/>
                        <ci>kaminus</ci>
                        <ci>O1_RyR</ci>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>dO2_RyR</ci>
                <apply>
                    <minus/>
                    <apply>
                        <times/>
                        <ci>kbplus</ci>
                        <apply>
                            <power/>
                            <apply>
                                <times/>
                                <ci>CaSS</ci>
                                <cn cellml:units="m2u">1000</cn>
                            </apply>
                            <ci>mcoop</ci>
                        </apply>
                        <ci>O1_RyR</ci>
                    </apply>
                    <apply>
                        <times/>
                        <ci>kbminus</ci>
                        <ci>O2_RyR</ci>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>dC2_RyR</ci>
                <apply>
                    <minus/>
                    <apply>
                        <times/>
                        <ci>kcplus</ci>
                        <ci>O1_RyR</ci>
                    </apply>
                    <apply>
                        <times/>
                        <ci>kcminus</ci>
                        <ci>C2_RyR</ci>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>dO1_RyR</ci>
                <apply>
                    <minus/>
                    <apply>
                        <plus/>
                        <ci>dC1_RyR</ci>
                        <ci>dO2_RyR</ci>
                        <ci>dC2_RyR</ci>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <apply>
                    <diff/>
                    <bvar>
                        <ci>time</ci>
                    </bvar>
                    <ci>C1_RyR</ci>
                </apply>
                <ci>dC1_RyR</ci>
            </apply>
            <apply>
                <eq/>
                <apply>
                    <diff/>
                    <bvar>
                        <ci>time</ci>
                    </bvar>
                    <ci>O2_RyR</ci>
                </apply>
                <ci>dO2_RyR</ci>
            </apply>
            <apply>
                <eq/>
                <apply>
                    <diff/>
                    <bvar>
                        <ci>time</ci>
                    </bvar>
                    <ci>C2_RyR</ci>
                </apply>
                <ci>dC2_RyR</ci>
            </apply>
            <apply>
                <eq/>
                <apply>
                    <diff/>
                    <bvar>
                        <ci>time</ci>
                    </bvar>
                    <ci>O1_RyR</ci>
                </apply>
                <ci>dO1_RyR</ci>
            </apply>
        </math>
    </component>
    <component name="COMPUTE_DERIVATIVES_OF_LTYPE_CHANNEL_STATES">
        <variable initial_value="0.3" name="fL" units="per_ms"/>
        <variable initial_value="4" name="gL" units="per_ms"/>
        <variable initial_value="2" name="bL" units="dimensionless"/>
        <variable initial_value="2" name="aL" units="dimensionless"/>
        <variable name="C0_to_C1" units="per_ms"/>
        <variable name="C1_to_C2" units="per_ms"/>
        <variable name="C2_to_C3" units="per_ms"/>
        <variable name="C3_to_C4" units="per_ms"/>
        <variable name="C1_to_C0" units="per_ms"/>
        <variable name="C2_to_C1" units="per_ms"/>
        <variable name="C3_to_C2" units="per_ms"/>
        <variable name="C4_to_C3" units="per_ms"/>
        <variable name="CCa0_to_CCa1" units="per_ms"/>
        <variable name="CCa1_to_CCa2" units="per_ms"/>
        <variable name="CCa2_to_CCa3" units="per_ms"/>
        <variable name="CCa3_to_CCa4" units="per_ms"/>
        <variable name="CCa1_to_CCa0" units="per_ms"/>
        <variable name="CCa2_to_CCa1" units="per_ms"/>
        <variable name="CCa3_to_CCa2" units="per_ms"/>
        <variable name="CCa4_to_CCa3" units="per_ms"/>
        <variable name="C0_to_CCa0" units="per_ms"/>
        <variable name="C1_to_CCa1" units="per_ms"/>
        <variable name="C2_to_CCa2" units="per_ms"/>
        <variable name="C3_to_CCa3" units="per_ms"/>
        <variable name="C4_to_CCa4" units="per_ms"/>
        <variable name="CCa0_to_C0" units="per_ms"/>
        <variable name="CCa1_to_C1" units="per_ms"/>
        <variable name="CCa2_to_C2" units="per_ms"/>
        <variable name="CCa3_to_C3" units="per_ms"/>
        <variable name="CCa4_to_C4" units="per_ms"/>
        <variable name="V" public_interface="in" units="mV"/>
        <variable name="alpha" units="per_ms"/>
        <variable name="beta" units="per_ms"/>
        <variable name="alpha_prime" units="per_ms"/>
        <variable name="beta_prime" units="per_ms"/>
        <variable name="gamma" units="per_ms"/>
        <variable name="omega" units="per_ms"/>
        <variable name="a1_Ca0" units="per_ms"/>
        <variable name="a2_Ca0" units="per_ms"/>
        <variable name="a1_Ca1" units="per_ms"/>
        <variable name="a2_Ca1" units="per_ms"/>
        <variable name="a1_Ca2" units="per_ms"/>
        <variable name="a2_Ca2" units="per_ms"/>
        <variable name="a1_Ca3" units="per_ms"/>
        <variable name="a2_Ca3" units="per_ms"/>
        <variable name="a1_Ca4" units="per_ms"/>
        <variable name="a2_Ca4" units="per_ms"/>
        <variable name="a1_C0" units="per_ms"/>
        <variable name="a2_C0" units="per_ms"/>
        <variable name="a1_C1" units="per_ms"/>
        <variable name="a2_C1" units="per_ms"/>
        <variable name="a1_C2" units="per_ms"/>
        <variable name="a2_C2" units="per_ms"/>
        <variable name="a1_C3" units="per_ms"/>
        <variable name="a2_C3" units="per_ms"/>
        <variable name="a1_C4" units="per_ms"/>
        <variable name="a2_C4" units="per_ms"/>
        <variable name="CaSS" public_interface="in" units="mM"/>
        <variable initial_value="0.8621934054" name="C0" units="dimensionless"/>
        <variable initial_value="0.01141398211" name="C1" units="dimensionless"/>
        <variable initial_value="5.666325225e-5" name="C2" units="dimensionless"/>
        <variable initial_value="1.25021357e-7" name="C3" units="dimensionless"/>
        <variable initial_value="1.034426748e-10" name="C4" units="dimensionless"/>
        <variable initial_value="0.1198547081" name="CCa0" units="dimensionless"/>
        <variable initial_value="0.006346794302" name="CCa1" units="dimensionless"/>
        <variable initial_value="1.260326488e-4" name="CCa2" units="dimensionless"/>
        <variable initial_value="1.112315238e-6" name="CCa3" units="dimensionless"/>
        <variable initial_value="3.681315892e-9" name="CCa4" units="dimensionless"/>
        <variable name="time" public_interface="in" units="ms"/>
        <variable initial_value="7.757981563e-12" name="Open" public_interface="out" units="dimensionless"/>
        <variable initial_value="0.9997157074" name="yCa" public_interface="out" units="dimensionless"/>
        <variable name="a1_Cainf" units="dimensionless"/>
        <variable name="yCa_inf" units="dimensionless"/>
        <variable name="tau_yCa" units="ms"/>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
                <eq/>
                <ci>alpha</ci>
                <apply>
                    <times/>
                    <cn cellml:units="per_ms">4</cn>
                    <cn cellml:units="dimensionless">1.2</cn>
                    <cn cellml:units="dimensionless">0.416</cn>
                    <apply>
                        <exp/>
                        <apply>
                            <times/>
                            <cn cellml:units="per_mV">0.012</cn>
                            <apply>
                                <minus/>
                                <ci>V</ci>
                                <cn cellml:units="mV">35</cn>
                            </apply>
                        </apply>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>beta</ci>
                <apply>
                    <times/>
                    <cn cellml:units="per_ms">4</cn>
                    <cn cellml:units="dimensionless">0.45</cn>
                    <cn cellml:units="dimensionless">0.049</cn>
                    <apply>
                        <exp/>
                        <apply>
                            <times/>
                            <apply>
                                <minus/>
                                <cn cellml:units="per_mV">0.065</cn>
                            </apply>
                            <apply>
                                <minus/>
                                <ci>V</ci>
                                <cn cellml:units="mV">22</cn>
                            </apply>
                        </apply>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>alpha_prime</ci>
                <apply>
                    <times/>
                    <ci>aL</ci>
                    <ci>alpha</ci>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>beta_prime</ci>
                <apply>
                    <divide/>
                    <ci>beta</ci>
                    <ci>bL</ci>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>gamma</ci>
                <apply>
                    <times/>
                    <cn cellml:units="per_ms">0.6</cn>
                    <cn cellml:units="per_mM">0.09233</cn>
                    <ci>CaSS</ci>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>omega</ci>
                <apply>
                    <times/>
                    <cn cellml:units="per_ms">0.25</cn>
                    <cn cellml:units="dimensionless">0.01</cn>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>C0_to_C1</ci>
                <apply>
                    <times/>
                    <cn cellml:units="dimensionless">4</cn>
                    <ci>alpha</ci>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>C1_to_C2</ci>
                <apply>
                    <times/>
                    <cn cellml:units="dimensionless">3</cn>
                    <ci>alpha</ci>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>C2_to_C3</ci>
                <apply>
                    <times/>
                    <cn cellml:units="dimensionless">2</cn>
                    <ci>alpha</ci>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>C3_to_C4</ci>
                <ci>alpha</ci>
            </apply>
            <apply>
                <eq/>
                <ci>CCa0_to_CCa1</ci>
                <apply>
                    <times/>
                    <cn cellml:units="dimensionless">4</cn>
                    <ci>alpha_prime</ci>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>CCa1_to_CCa2</ci>
                <apply>
                    <times/>
                    <cn cellml:units="dimensionless">3</cn>
                    <ci>alpha_prime</ci>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>CCa2_to_CCa3</ci>
                <apply>
                    <times/>
                    <cn cellml:units="dimensionless">2</cn>
                    <ci>alpha_prime</ci>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>CCa3_to_CCa4</ci>
                <ci>alpha_prime</ci>
            </apply>
            <apply>
                <eq/>
                <ci>C1_to_C0</ci>
                <ci>beta</ci>
            </apply>
            <apply>
                <eq/>
                <ci>C2_to_C1</ci>
                <apply>
                    <times/>
                    <cn cellml:units="dimensionless">2</cn>
                    <ci>beta</ci>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>C3_to_C2</ci>
                <apply>
                    <times/>
                    <cn cellml:units="dimensionless">3</cn>
                    <ci>beta</ci>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>C4_to_C3</ci>
                <apply>
                    <times/>
                    <cn cellml:units="dimensionless">4</cn>
                    <ci>beta</ci>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>CCa1_to_CCa0</ci>
                <ci>beta_prime</ci>
            </apply>
            <apply>
                <eq/>
                <ci>CCa2_to_CCa1</ci>
                <apply>
                    <times/>
                    <cn cellml:units="dimensionless">2</cn>
                    <ci>beta_prime</ci>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>CCa3_to_CCa2</ci>
                <apply>
                    <times/>
                    <cn cellml:units="dimensionless">3</cn>
                    <ci>beta_prime</ci>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>CCa4_to_CCa3</ci>
                <apply>
                    <times/>
                    <cn cellml:units="dimensionless">4</cn>
                    <ci>beta_prime</ci>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>C0_to_CCa0</ci>
                <ci>gamma</ci>
            </apply>
            <apply>
                <eq/>
                <ci>C1_to_CCa1</ci>
                <apply>
                    <times/>
                    <ci>aL</ci>
                    <ci>C0_to_CCa0</ci>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>C2_to_CCa2</ci>
                <apply>
                    <times/>
                    <ci>aL</ci>
                    <ci>C1_to_CCa1</ci>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>C3_to_CCa3</ci>
                <apply>
                    <times/>
                    <ci>aL</ci>
                    <ci>C2_to_CCa2</ci>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>C4_to_CCa4</ci>
                <apply>
                    <times/>
                    <ci>aL</ci>
                    <ci>C3_to_CCa3</ci>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>CCa0_to_C0</ci>
                <ci>omega</ci>
            </apply>
            <apply>
                <eq/>
                <ci>CCa1_to_C1</ci>
                <apply>
                    <divide/>
                    <ci>CCa0_to_C0</ci>
                    <ci>bL</ci>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>CCa2_to_C2</ci>
                <apply>
                    <divide/>
                    <ci>CCa1_to_C1</ci>
                    <ci>bL</ci>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>CCa3_to_C3</ci>
                <apply>
                    <divide/>
                    <ci>CCa2_to_C2</ci>
                    <ci>bL</ci>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>CCa4_to_C4</ci>
                <apply>
                    <divide/>
                    <ci>CCa3_to_C3</ci>
                    <ci>bL</ci>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>a1_C0</ci>
                <apply>
                    <times/>
                    <apply>
                        <plus/>
                        <ci>C0_to_C1</ci>
                        <ci>C0_to_CCa0</ci>
                    </apply>
                    <ci>C0</ci>
                </apply>
            </apply>
            <apply>
                <eq/>
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                    <cn cellml:units="dimensionless">3</cn>
                    <ci>beta_act43</ci>
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                    <cn cellml:units="dimensionless">4</cn>
                    <ci>beta_act43</ci>
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                        <ci>f1Kv43</ci>
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        <variable name="a2_CI2" units="per_ms"/>
        <variable initial_value="0.02287858869" name="CI2Kv14" public_interface="out" units="dimensionless"/>
        <variable name="a1_CI3" units="per_ms"/>
        <variable name="a2_CI3" units="per_ms"/>
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        <variable name="a2_OI" units="per_ms"/>
        <variable initial_value="0.1134082058" name="OIKv14" public_interface="out" units="dimensionless"/>
        <variable name="time" public_interface="in" units="ms"/>
        <variable name="V" public_interface="in" units="mV"/>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
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                <eq/>
                <ci>alpha_act14</ci>
                <apply>
                    <times/>
                    <ci>alphaa0Kv14</ci>
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                        <exp/>
                        <apply>
                            <times/>
                            <ci>aaKv14</ci>
                            <ci>V</ci>
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                <eq/>
                <ci>beta_act14</ci>
                <apply>
                    <times/>
                    <ci>betaa0Kv14</ci>
                    <apply>
                        <exp/>
                        <apply>
                            <times/>
                            <apply>
                                <minus/>
                                <ci>baKv14</ci>
                            </apply>
                            <ci>V</ci>
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                </apply>
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            <apply>
                <eq/>
                <ci>alpha_inact14</ci>
                <ci>alphai0Kv14</ci>
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            <apply>
                <eq/>
                <ci>beta_inact14</ci>
                <ci>betai0Kv14</ci>
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                <eq/>
                <ci>C0Kv14_to_C1Kv14</ci>
                <apply>
                    <times/>
                    <cn cellml:units="dimensionless">4</cn>
                    <ci>alpha_act14</ci>
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                <eq/>
                <ci>C1Kv14_to_C2Kv14</ci>
                <apply>
                    <times/>
                    <cn cellml:units="dimensionless">3</cn>
                    <ci>alpha_act14</ci>
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                <eq/>
                <ci>C2Kv14_to_C3Kv14</ci>
                <apply>
                    <times/>
                    <cn cellml:units="dimensionless">2</cn>
                    <ci>alpha_act14</ci>
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                <eq/>
                <ci>C3Kv14_to_OKv14</ci>
                <ci>alpha_act14</ci>
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            <apply>
                <eq/>
                <ci>CI0Kv14_to_CI1Kv14</ci>
                <apply>
                    <times/>
                    <cn cellml:units="dimensionless">4</cn>
                    <ci>b1Kv14</ci>
                    <ci>alpha_act14</ci>
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            </apply>
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                <eq/>
                <ci>CI1Kv14_to_CI2Kv14</ci>
                <apply>
                    <divide/>
                    <apply>
                        <times/>
                        <cn cellml:units="dimensionless">3</cn>
                        <ci>b2Kv14</ci>
                        <ci>alpha_act14</ci>
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                    <ci>b1Kv14</ci>
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                <eq/>
                <ci>CI2Kv14_to_CI3Kv14</ci>
                <apply>
                    <divide/>
                    <apply>
                        <times/>
                        <cn cellml:units="dimensionless">2</cn>
                        <ci>b3Kv14</ci>
                        <ci>alpha_act14</ci>
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                    <ci>b2Kv14</ci>
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            <apply>
                <eq/>
                <ci>CI3Kv14_to_OIKv14</ci>
                <apply>
                    <divide/>
                    <apply>
                        <times/>
                        <ci>b4Kv14</ci>
                        <ci>alpha_act14</ci>
                    </apply>
                    <ci>b3Kv14</ci>
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            </apply>
            <apply>
                <eq/>
                <ci>C1Kv14_to_C0Kv14</ci>
                <ci>beta_act14</ci>
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            <apply>
                <eq/>
                <ci>C2Kv14_to_C1Kv14</ci>
                <apply>
                    <times/>
                    <cn cellml:units="dimensionless">2</cn>
                    <ci>beta_act14</ci>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>C3Kv14_to_C2Kv14</ci>
                <apply>
                    <times/>
                    <cn cellml:units="dimensionless">3</cn>
                    <ci>beta_act14</ci>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>OKv14_to_C3Kv14</ci>
                <apply>
                    <times/>
                    <cn cellml:units="dimensionless">4</cn>
                    <ci>beta_act14</ci>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>CI1Kv14_to_CI0Kv14</ci>
                <apply>
                    <divide/>
                    <ci>beta_act14</ci>
                    <ci>f1Kv14</ci>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>CI2Kv14_to_CI1Kv14</ci>
                <apply>
                    <divide/>
                    <apply>
                        <times/>
                        <cn cellml:units="dimensionless">2</cn>
                        <ci>f1Kv14</ci>
                        <ci>beta_act14</ci>
                    </apply>
                    <ci>f2Kv14</ci>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>CI3Kv14_to_CI2Kv14</ci>
                <apply>
                    <divide/>
                    <apply>
                        <times/>
                        <cn cellml:units="dimensionless">3</cn>
                        <ci>f2Kv14</ci>
                        <ci>beta_act14</ci>
                    </apply>
                    <ci>f3Kv14</ci>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>OIKv14_to_CI3Kv14</ci>
                <apply>
                    <divide/>
                    <apply>
                        <times/>
                        <cn cellml:units="dimensionless">4</cn>
                        <ci>f3Kv14</ci>
                        <ci>beta_act14</ci>
                    </apply>
                    <ci>f4Kv14</ci>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>C0Kv14_to_CI0Kv14</ci>
                <ci>beta_inact14</ci>
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            <apply>
                <eq/>
                <ci>C1Kv14_to_CI1Kv14</ci>
                <apply>
                    <times/>
                    <ci>f1Kv14</ci>
                    <ci>beta_inact14</ci>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>C2Kv14_to_CI2Kv14</ci>
                <apply>
                    <times/>
                    <ci>f2Kv14</ci>
                    <ci>beta_inact14</ci>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>C3Kv14_to_CI3Kv14</ci>
                <apply>
                    <times/>
                    <ci>f3Kv14</ci>
                    <ci>beta_inact14</ci>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>OKv14_to_OIKv14</ci>
                <apply>
                    <times/>
                    <ci>f4Kv14</ci>
                    <ci>beta_inact14</ci>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>CI0Kv14_to_C0Kv14</ci>
                <ci>alpha_inact14</ci>
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            <apply>
                <eq/>
                <ci>CI1Kv14_to_C1Kv14</ci>
                <apply>
                    <divide/>
                    <ci>alpha_inact14</ci>
                    <ci>b1Kv14</ci>
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            <apply>
                <eq/>
                <ci>CI2Kv14_to_C2Kv14</ci>
                <apply>
                    <divide/>
                    <ci>alpha_inact14</ci>
                    <ci>b2Kv14</ci>
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            <apply>
                <eq/>
                <ci>CI3Kv14_to_C3Kv14</ci>
                <apply>
                    <divide/>
                    <ci>alpha_inact14</ci>
                    <ci>b3Kv14</ci>
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            <apply>
                <eq/>
                <ci>OIKv14_to_OKv14</ci>
                <apply>
                    <divide/>
                    <ci>alpha_inact14</ci>
                    <ci>b4Kv14</ci>
                </apply>
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            <apply>
                <eq/>
                <ci>a1_C0</ci>
                <apply>
                    <times/>
                    <apply>
                        <plus/>
                        <ci>C0Kv14_to_C1Kv14</ci>
                        <ci>C0Kv14_to_CI0Kv14</ci>
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                    <ci>C0Kv14</ci>
                </apply>
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            <apply>
                <eq/>
                <ci>a2_C0</ci>
                <apply>
                    <plus/>
                    <apply>
                        <times/>
                        <ci>C1Kv14_to_C0Kv14</ci>
                        <ci>C1Kv14</ci>
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                    <apply>
                        <times/>
                        <ci>CI0Kv14_to_C0Kv14</ci>
                        <ci>CI0Kv14</ci>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <apply>
                    <diff/>
                    <bvar>
                        <ci>time</ci>
                    </bvar>
                    <ci>C0Kv14</ci>
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                <apply>
                    <minus/>
                    <ci>a2_C0</ci>
                    <ci>a1_C0</ci>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>a1_C1</ci>
                <apply>
                    <times/>
                    <apply>
                        <plus/>
                        <ci>C1Kv14_to_C2Kv14</ci>
                        <ci>C1Kv14_to_C0Kv14</ci>
                        <ci>C1Kv14_to_CI1Kv14</ci>
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                    <ci>C1Kv14</ci>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>a2_C1</ci>
                <apply>
                    <plus/>
                    <apply>
                        <times/>
                        <ci>C2Kv14_to_C1Kv14</ci>
                        <ci>C2Kv14</ci>
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                    <apply>
                        <times/>
                        <ci>CI1Kv14_to_C1Kv14</ci>
                        <ci>CI1Kv14</ci>
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                    <apply>
                        <times/>
                        <ci>C0Kv14_to_C1Kv14</ci>
                        <ci>C0Kv14</ci>
                    </apply>
                </apply>
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            <apply>
                <eq/>
                <apply>
                    <diff/>
                    <bvar>
                        <ci>time</ci>
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                    <ci>C1Kv14</ci>
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                    <minus/>
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                <eq/>
                <ci>a1_C2</ci>
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                    <times/>
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                        <plus/>
                        <ci>C2Kv14_to_C3Kv14</ci>
                        <ci>C2Kv14_to_C1Kv14</ci>
                        <ci>C2Kv14_to_CI2Kv14</ci>
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                <eq/>
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                    <plus/>
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                        <times/>
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                        <ci>C3Kv14</ci>
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                        <times/>
                        <ci>CI2Kv14_to_C2Kv14</ci>
                        <ci>CI2Kv14</ci>
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                        <times/>
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                        <ci>C1Kv14</ci>
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                        <ci>C3Kv14_to_CI3Kv14</ci>
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                        <ci>OKv14</ci>
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                        <ci>CI3Kv14_to_C3Kv14</ci>
                        <ci>CI3Kv14</ci>
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                        <ci>time</ci>
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                <ci>a1_O</ci>
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                        <ci>OKv14_to_C3Kv14</ci>
                        <ci>OKv14_to_OIKv14</ci>
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                        <times/>
                        <ci>C3Kv14_to_OKv14</ci>
                        <ci>C3Kv14</ci>
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                    <apply>
                        <times/>
                        <ci>OIKv14_to_OKv14</ci>
                        <ci>OIKv14</ci>
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                    <diff/>
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                        <ci>time</ci>
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                    <ci>a1_O</ci>
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                <eq/>
                <ci>a1_CI0</ci>
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                    <times/>
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                        <ci>CI0Kv14_to_C0Kv14</ci>
                        <ci>CI0Kv14_to_CI1Kv14</ci>
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                    <ci>CI0Kv14</ci>
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                        <ci>C0Kv14_to_CI0Kv14</ci>
                        <ci>C0Kv14</ci>
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                        <times/>
                        <ci>CI1Kv14_to_CI0Kv14</ci>
                        <ci>CI1Kv14</ci>
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                    <diff/>
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                        <ci>time</ci>
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                    <minus/>
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                <eq/>
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                    <times/>
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                        <ci>CI1Kv14_to_C1Kv14</ci>
                        <ci>CI1Kv14_to_CI0Kv14</ci>
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                        <times/>
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                        <ci>CI2Kv14</ci>
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                        <times/>
                        <ci>C1Kv14_to_CI1Kv14</ci>
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                        <times/>
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                        <ci>CI0Kv14</ci>
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                <eq/>
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                    <times/>
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                        <ci>CI2Kv14_to_CI3Kv14</ci>
                        <ci>CI2Kv14_to_C2Kv14</ci>
                        <ci>CI2Kv14_to_CI1Kv14</ci>
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                    <plus/>
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                        <times/>
                        <ci>CI3Kv14_to_CI2Kv14</ci>
                        <ci>CI3Kv14</ci>
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                    <apply>
                        <times/>
                        <ci>C2Kv14_to_CI2Kv14</ci>
                        <ci>C2Kv14</ci>
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                    <apply>
                        <times/>
                        <ci>CI1Kv14_to_CI2Kv14</ci>
                        <ci>CI1Kv14</ci>
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            <apply>
                <eq/>
                <apply>
                    <diff/>
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                        <ci>time</ci>
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                    <ci>CI2Kv14</ci>
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                <apply>
                    <minus/>
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                    <ci>a1_CI2</ci>
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            </apply>
            <apply>
                <eq/>
                <ci>a1_CI3</ci>
                <apply>
                    <times/>
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                        <plus/>
                        <ci>CI3Kv14_to_OIKv14</ci>
                        <ci>CI3Kv14_to_C3Kv14</ci>
                        <ci>CI3Kv14_to_CI2Kv14</ci>
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                    <ci>CI3Kv14</ci>
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                <eq/>
                <ci>a2_CI3</ci>
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                    <plus/>
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                        <times/>
                        <ci>OIKv14_to_CI3Kv14</ci>
                        <ci>OIKv14</ci>
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                    <apply>
                        <times/>
                        <ci>C3Kv14_to_CI3Kv14</ci>
                        <ci>C3Kv14</ci>
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                    <apply>
                        <times/>
                        <ci>CI2Kv14_to_CI3Kv14</ci>
                        <ci>CI2Kv14</ci>
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                <eq/>
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                    <diff/>
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                    <ci>CI3Kv14</ci>
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                    <minus/>
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                    <ci>a1_CI3</ci>
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            <apply>
                <eq/>
                <ci>a1_OI</ci>
                <apply>
                    <times/>
                    <apply>
                        <plus/>
                        <ci>OIKv14_to_OKv14</ci>
                        <ci>OIKv14_to_CI3Kv14</ci>
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                    <ci>OIKv14</ci>
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                <eq/>
                <ci>a2_OI</ci>
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                    <plus/>
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                        <times/>
                        <ci>OKv14_to_OIKv14</ci>
                        <ci>OKv14</ci>
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                    <apply>
                        <times/>
                        <ci>CI3Kv14_to_OIKv14</ci>
                        <ci>CI3Kv14</ci>
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                </apply>
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            <apply>
                <eq/>
                <apply>
                    <diff/>
                    <bvar>
                        <ci>time</ci>
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                    <ci>OIKv14</ci>
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                <apply>
                    <minus/>
                    <ci>a2_OI</ci>
                    <ci>a1_OI</ci>
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            </apply>
        </math>
    </component>
    <component name="COMPUTE_REVERSAL_POTENTIALS">
        <variable name="ENa" public_interface="out" units="mV"/>
        <variable name="EK" public_interface="out" units="mV"/>
        <variable name="EKs" public_interface="out" units="mV"/>
        <variable name="ECa" public_interface="out" units="mV"/>
        <variable name="RT_over_F" public_interface="in" units="mV"/>
        <variable name="Nao" public_interface="in" units="mM"/>
        <variable name="Nai" public_interface="in" units="mM"/>
        <variable name="Ko" public_interface="in" units="mM"/>
        <variable name="Ki" public_interface="in" units="mM"/>
        <variable name="Cao" public_interface="in" units="mM"/>
        <variable name="Cai" public_interface="in" units="mM"/>
        <variable name="a1" units="mM"/>
        <variable name="a2" units="mM"/>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
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                <ci>ENa</ci>
                <apply>
                    <times/>
                    <ci>RT_over_F</ci>
                    <apply>
                        <ln/>
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                            <ci>Nao</ci>
                            <ci>Nai</ci>
                        </apply>
                    </apply>
                </apply>
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                <eq/>
                <ci>EK</ci>
                <apply>
                    <times/>
                    <ci>RT_over_F</ci>
                    <apply>
                        <ln/>
                        <apply>
                            <divide/>
                            <ci>Ko</ci>
                            <ci>Ki</ci>
                        </apply>
                    </apply>
                </apply>
            </apply>
            <apply>
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                <ci>a1</ci>
                <apply>
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                    <ci>Ko</ci>
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                        <times/>
                        <cn cellml:units="dimensionless">0.01833</cn>
                        <ci>Nao</ci>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>a2</ci>
                <apply>
                    <plus/>
                    <ci>Ki</ci>
                    <apply>
                        <times/>
                        <cn cellml:units="dimensionless">0.01833</cn>
                        <ci>Nai</ci>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>EKs</ci>
                <apply>
                    <times/>
                    <ci>RT_over_F</ci>
                    <apply>
                        <ln/>
                        <apply>
                            <divide/>
                            <ci>a1</ci>
                            <ci>a2</ci>
                        </apply>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>ECa</ci>
                <apply>
                    <times/>
                    <cn cellml:units="dimensionless">0.5</cn>
                    <ci>RT_over_F</ci>
                    <apply>
                        <ln/>
                        <apply>
                            <divide/>
                            <ci>Cao</ci>
                            <ci>Cai</ci>
                        </apply>
                    </apply>
                </apply>
            </apply>
        </math>
    </component>
    <component name="COMPUTE_INa_IKr_IKs_Ito1_IK1_INab_IKp">
        <variable initial_value="0.0186e0" name="GKr" units="mS_per_uF"/>
        <variable initial_value="0.0035e0" name="GKs" units="mS_per_uF"/>
        <variable initial_value="0.1253051261188079722568586886469e0" name="GK1" units="mS_per_uF"/>
        <variable initial_value="56.32e0" name="GNa" units="mS_per_uF"/>
        <variable initial_value="0.001e0" name="GNab" units="mS_per_uF"/>
        <variable initial_value="0.872" name="KvScale" units="dimensionless"/>
        <variable initial_value="0.889" name="Kv43Frac" units="dimensionless"/>
        <variable name="GKv43" units="mS_per_uF"/>
        <variable name="PKv14" units="litre_per_farad_second"/>
        <variable name="OKv14" public_interface="in" units="dimensionless"/>
        <variable name="na6" public_interface="in" units="dimensionless"/>
        <variable name="na7" public_interface="in" units="dimensionless"/>
        <variable name="V" public_interface="in" units="mV"/>
        <variable name="ENa" public_interface="in" units="mV"/>
        <variable name="Ko" public_interface="in" units="mM"/>
        <variable name="OHerg" public_interface="in" units="dimensionless"/>
        <variable name="O1ks" public_interface="in" units="dimensionless"/>
        <variable name="O2ks" public_interface="in" units="dimensionless"/>
        <variable name="OKv43" public_interface="in" units="dimensionless"/>
        <variable name="RT_over_F" public_interface="in" units="mV"/>
        <variable name="Faraday" public_interface="in" units="coulomb_per_millimole"/>
        <variable name="Ki" public_interface="in" units="mM"/>
        <variable name="EK" public_interface="in" units="mV"/>
        <variable name="fKo" units="dimensionless"/>
        <variable name="VF_over_RT" units="dimensionless"/>
        <variable name="VFsq_over_RT" units="coulomb_per_millimole"/>
        <variable name="a1_K" units="mM"/>
        <variable name="a2" units="dimensionless"/>
        <variable name="a1_Na" units="mM"/>
        <variable name="K1_inf" units="dimensionless"/>
        <variable cmeta:id="COMPUTE_INa_IKr_IKs_Ito1_IK1_INab_IKp_IKr" name="IKr" public_interface="out" units="uA_per_uF"/>
        <variable cmeta:id="COMPUTE_INa_IKr_IKs_Ito1_IK1_INab_IKp_IKs" name="IKs" public_interface="out" units="uA_per_uF"/>
        <variable name="IKv43" public_interface="out" units="uA_per_uF"/>
        <variable name="IKv14_K" public_interface="out" units="uA_per_uF"/>
        <variable name="Nai" public_interface="in" units="mM"/>
        <variable name="Nao" public_interface="in" units="mM"/>
        <variable name="IKv14_Na" public_interface="out" units="uA_per_uF"/>
        <variable name="IKv14" public_interface="out" units="uA_per_uF"/>
        <variable cmeta:id="COMPUTE_INa_IKr_IKs_Ito1_IK1_INab_IKp_Ito1" name="Ito1" public_interface="out" units="uA_per_uF"/>
        <variable cmeta:id="COMPUTE_INa_IKr_IKs_Ito1_IK1_INab_IKp_IK1" name="IK1" public_interface="out" units="uA_per_uF"/>
        <variable cmeta:id="COMPUTE_INa_IKr_IKs_Ito1_IK1_INab_IKp_INab" name="INab" public_interface="out" units="uA_per_uF"/>
        <variable cmeta:id="COMPUTE_INa_IKr_IKs_Ito1_IK1_INab_IKp_INa" name="INa" public_interface="out" units="uA_per_uF"/>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
                <eq/>
                <ci>PKv14</ci>
                <apply>
                    <times/>
                    <apply>
                        <minus/>
                        <cn cellml:units="dimensionless">1</cn>
                        <ci>Kv43Frac</ci>
                    </apply>
                    <ci>KvScale</ci>
                    <cn cellml:units="litre_per_farad_second" type="e-notation">4.2986<sep/>-7</cn>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>GKv43</ci>
                <apply>
                    <times/>
                    <ci>Kv43Frac</ci>
                    <ci>KvScale</ci>
                    <cn cellml:units="mS_per_uF">0.1</cn>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>INa</ci>
                <apply>
                    <times/>
                    <ci>GNa</ci>
                    <apply>
                        <plus/>
                        <ci>na6</ci>
                        <ci>na7</ci>
                    </apply>
                    <apply>
                        <minus/>
                        <ci>V</ci>
                        <ci>ENa</ci>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>fKo</ci>
                <apply>
                    <root/>
                    <apply>
                        <divide/>
                        <ci>Ko</ci>
                        <cn cellml:units="mM">4</cn>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>IKr</ci>
                <apply>
                    <times/>
                    <ci>GKr</ci>
                    <ci>fKo</ci>
                    <ci>OHerg</ci>
                    <apply>
                        <minus/>
                        <ci>V</ci>
                        <ci>EK</ci>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>IKs</ci>
                <apply>
                    <times/>
                    <ci>GKs</ci>
                    <apply>
                        <plus/>
                        <ci>O1ks</ci>
                        <ci>O2ks</ci>
                    </apply>
                    <apply>
                        <minus/>
                        <ci>V</ci>
                        <ci>EK</ci>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>IKv43</ci>
                <apply>
                    <times/>
                    <ci>GKv43</ci>
                    <ci>OKv43</ci>
                    <apply>
                        <minus/>
                        <ci>V</ci>
                        <ci>EK</ci>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>VF_over_RT</ci>
                <apply>
                    <divide/>
                    <ci>V</ci>
                    <ci>RT_over_F</ci>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>VFsq_over_RT</ci>
                <apply>
                    <times/>
                    <cn cellml:units="dimensionless">1000</cn>
                    <ci>Faraday</ci>
                    <ci>VF_over_RT</ci>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>a1_K</ci>
                <apply>
                    <minus/>
                    <apply>
                        <times/>
                        <ci>Ki</ci>
                        <apply>
                            <exp/>
                            <ci>VF_over_RT</ci>
                        </apply>
                    </apply>
                    <ci>Ko</ci>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>a2</ci>
                <apply>
                    <minus/>
                    <apply>
                        <exp/>
                        <ci>VF_over_RT</ci>
                    </apply>
                    <cn cellml:units="dimensionless">1</cn>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>IKv14_K</ci>
                <apply>
                    <divide/>
                    <apply>
                        <times/>
                        <ci>PKv14</ci>
                        <ci>OKv14</ci>
                        <ci>VFsq_over_RT</ci>
                        <ci>a1_K</ci>
                    </apply>
                    <ci>a2</ci>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>a1_Na</ci>
                <apply>
                    <minus/>
                    <apply>
                        <times/>
                        <ci>Nai</ci>
                        <apply>
                            <exp/>
                            <ci>VF_over_RT</ci>
                        </apply>
                    </apply>
                    <ci>Nao</ci>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>IKv14_Na</ci>
                <apply>
                    <divide/>
                    <apply>
                        <times/>
                        <cn cellml:units="dimensionless">0.02</cn>
                        <ci>PKv14</ci>
                        <ci>OKv14</ci>
                        <ci>VFsq_over_RT</ci>
                        <ci>a1_Na</ci>
                    </apply>
                    <ci>a2</ci>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>IKv14</ci>
                <apply>
                    <plus/>
                    <ci>IKv14_K</ci>
                    <ci>IKv14_Na</ci>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>Ito1</ci>
                <apply>
                    <plus/>
                    <ci>IKv43</ci>
                    <ci>IKv14</ci>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>K1_inf</ci>
                <apply>
                    <divide/>
                    <cn cellml:units="dimensionless">1</cn>
                    <apply>
                        <plus/>
                        <cn cellml:units="dimensionless">0.94</cn>
                        <apply>
                            <exp/>
                            <apply>
                                <times/>
                                <apply>
                                    <divide/>
                                    <cn cellml:units="dimensionless">1.26</cn>
                                    <ci>RT_over_F</ci>
                                </apply>
                                <apply>
                                    <minus/>
                                    <ci>V</ci>
                                    <ci>EK</ci>
                                </apply>
                            </apply>
                        </apply>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>IK1</ci>
                <apply>
                    <times/>
                    <ci>GK1</ci>
                    <apply>
                        <root/>
                        <apply>
                            <divide/>
                            <ci>Ko</ci>
                            <cn cellml:units="mM">1</cn>
                        </apply>
                    </apply>
                    <ci>K1_inf</ci>
                    <apply>
                        <minus/>
                        <ci>V</ci>
                        <ci>EK</ci>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>INab</ci>
                <apply>
                    <times/>
                    <ci>GNab</ci>
                    <apply>
                        <minus/>
                        <ci>V</ci>
                        <ci>ENa</ci>
                    </apply>
                </apply>
            </apply>
        </math>
    </component>
    <component name="COMPUTE_INaK_INaCa_ICab_IpCa">
        <variable name="V" public_interface="in" units="mV"/>
        <variable name="ECa" public_interface="in" units="mV"/>
        <variable name="RT_over_F" public_interface="in" units="mV"/>
        <variable name="Nai" public_interface="in" units="mM"/>
        <variable name="Nao" public_interface="in" units="mM"/>
        <variable name="Ko" public_interface="in" units="mM"/>
        <variable name="Cai" public_interface="in" units="mM"/>
        <variable name="Cao" public_interface="in" units="mM"/>
        <variable initial_value="0.44" name="kNaCa" units="uA_per_uF"/>
        <variable initial_value="87.5" name="KmNa" units="mM"/>
        <variable initial_value="1.38" name="KmCa" units="mM"/>
        <variable initial_value="0.2" name="ksat" units="dimensionless"/>
        <variable initial_value="0.35" name="eta" units="dimensionless"/>
        <variable initial_value="2.387" name="INaKmax" units="uA_per_uF"/>
        <variable initial_value="20" name="KmNai" units="mM"/>
        <variable initial_value="1.5" name="KmKo" units="mM"/>
        <variable initial_value="0.05" name="IpCamax" units="uA_per_uF"/>
        <variable initial_value="0.0005" name="KmpCa" units="mM"/>
        <variable initial_value="7.684e-5" name="GCab" units="mS_per_uF"/>
        <variable name="VF_over_RT" units="dimensionless"/>
        <variable name="sigma" units="dimensionless"/>
        <variable name="a1_Na" units="dimensionless"/>
        <variable name="a2_Na" units="dimensionless"/>
        <variable name="fNaK" units="dimensionless"/>
        <variable name="a1_K" units="dimensionless"/>
        <variable name="a2_K" units="dimensionless"/>
        <variable cmeta:id="COMPUTE_INaK_INaCa_ICab_IpCa_INaK" name="INaK" public_interface="out" units="uA_per_uF"/>
        <variable name="a1_ncx" units="mM4"/>
        <variable name="a2_ncx" units="mM4"/>
        <variable name="a3_ncx" units="dimensionless"/>
        <variable name="a4_ncx" units="mM"/>
        <variable name="a5_ncx" units="mM3"/>
        <variable cmeta:id="COMPUTE_INaK_INaCa_ICab_IpCa_INaCa" name="INaCa" public_interface="out" units="uA_per_uF"/>
        <variable cmeta:id="COMPUTE_INaK_INaCa_ICab_IpCa_ICab" name="ICab" public_interface="out" units="uA_per_uF"/>
        <variable cmeta:id="COMPUTE_INaK_INaCa_ICab_IpCa_IpCa" name="IpCa" public_interface="out" units="uA_per_uF"/>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
                <eq/>
                <ci>ICab</ci>
                <apply>
                    <times/>
                    <ci>GCab</ci>
                    <apply>
                        <minus/>
                        <ci>V</ci>
                        <ci>ECa</ci>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>IpCa</ci>
                <apply>
                    <divide/>
                    <apply>
                        <times/>
                        <ci>IpCamax</ci>
                        <ci>Cai</ci>
                    </apply>
                    <apply>
                        <plus/>
                        <ci>KmpCa</ci>
                        <ci>Cai</ci>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>VF_over_RT</ci>
                <apply>
                    <divide/>
                    <ci>V</ci>
                    <ci>RT_over_F</ci>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>sigma</ci>
                <apply>
                    <divide/>
                    <apply>
                        <minus/>
                        <apply>
                            <exp/>
                            <apply>
                                <divide/>
                                <ci>Nao</ci>
                                <cn cellml:units="mM">67.3</cn>
                            </apply>
                        </apply>
                        <cn cellml:units="dimensionless">1</cn>
                    </apply>
                    <cn cellml:units="dimensionless">7</cn>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>a1_Na</ci>
                <apply>
                    <plus/>
                    <cn cellml:units="dimensionless">1</cn>
                    <apply>
                        <times/>
                        <cn cellml:units="dimensionless">0.1245</cn>
                        <apply>
                            <exp/>
                            <apply>
                                <times/>
                                <apply>
                                    <minus/>
                                    <cn cellml:units="dimensionless">0.1</cn>
                                </apply>
                                <ci>VF_over_RT</ci>
                            </apply>
                        </apply>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>a2_Na</ci>
                <apply>
                    <times/>
                    <cn cellml:units="dimensionless">0.0365</cn>
                    <ci>sigma</ci>
                    <apply>
                        <exp/>
                        <apply>
                            <times/>
                            <apply>
                                <minus/>
                                <cn cellml:units="dimensionless">1.33</cn>
                            </apply>
                            <ci>VF_over_RT</ci>
                        </apply>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>fNaK</ci>
                <apply>
                    <divide/>
                    <cn cellml:units="dimensionless">1</cn>
                    <apply>
                        <plus/>
                        <ci>a1_Na</ci>
                        <ci>a2_Na</ci>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>a1_K</ci>
                <apply>
                    <divide/>
                    <ci>Ko</ci>
                    <apply>
                        <plus/>
                        <ci>Ko</ci>
                        <ci>KmKo</ci>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>a2_K</ci>
                <apply>
                    <plus/>
                    <cn cellml:units="dimensionless">1</cn>
                    <apply>
                        <power/>
                        <apply>
                            <divide/>
                            <ci>KmNai</ci>
                            <ci>Nai</ci>
                        </apply>
                        <cn cellml:units="dimensionless">1.5</cn>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>INaK</ci>
                <apply>
                    <divide/>
                    <apply>
                        <times/>
                        <ci>INaKmax</ci>
                        <ci>fNaK</ci>
                        <ci>a1_K</ci>
                    </apply>
                    <ci>a2_K</ci>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>a1_ncx</ci>
                <apply>
                    <times/>
                    <apply>
                        <exp/>
                        <apply>
                            <times/>
                            <ci>eta</ci>
                            <ci>VF_over_RT</ci>
                        </apply>
                    </apply>
                    <apply>
                        <power/>
                        <ci>Nai</ci>
                        <cn cellml:units="dimensionless">3</cn>
                    </apply>
                    <ci>Cao</ci>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>a2_ncx</ci>
                <apply>
                    <times/>
                    <apply>
                        <exp/>
                        <apply>
                            <times/>
                            <apply>
                                <minus/>
                                <ci>eta</ci>
                                <cn cellml:units="dimensionless">1</cn>
                            </apply>
                            <ci>VF_over_RT</ci>
                        </apply>
                    </apply>
                    <apply>
                        <power/>
                        <ci>Nao</ci>
                        <cn cellml:units="dimensionless">3</cn>
                    </apply>
                    <ci>Cai</ci>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>a3_ncx</ci>
                <apply>
                    <plus/>
                    <cn cellml:units="dimensionless">1</cn>
                    <apply>
                        <times/>
                        <ci>ksat</ci>
                        <apply>
                            <exp/>
                            <apply>
                                <times/>
                                <apply>
                                    <minus/>
                                    <ci>eta</ci>
                                    <cn cellml:units="dimensionless">1</cn>
                                </apply>
                                <ci>VF_over_RT</ci>
                            </apply>
                        </apply>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>a4_ncx</ci>
                <apply>
                    <plus/>
                    <ci>KmCa</ci>
                    <ci>Cao</ci>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>a5_ncx</ci>
                <apply>
                    <divide/>
                    <apply>
                        <plus/>
                        <apply>
                            <power/>
                            <ci>KmNa</ci>
                            <cn cellml:units="dimensionless">3</cn>
                        </apply>
                        <apply>
                            <power/>
                            <ci>Nao</ci>
                            <cn cellml:units="dimensionless">3</cn>
                        </apply>
                    </apply>
                    <cn cellml:units="dimensionless">5000</cn>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>INaCa</ci>
                <apply>
                    <divide/>
                    <apply>
                        <times/>
                        <ci>kNaCa</ci>
                        <apply>
                            <minus/>
                            <ci>a1_ncx</ci>
                            <ci>a2_ncx</ci>
                        </apply>
                    </apply>
                    <apply>
                        <times/>
                        <ci>a4_ncx</ci>
                        <ci>a3_ncx</ci>
                        <ci>a5_ncx</ci>
                    </apply>
                </apply>
            </apply>
        </math>
    </component>
    <component name="COMPUTE_ICa_ICaK">
        <variable name="Ko" public_interface="in" units="mM"/>
        <variable name="Ki" public_interface="in" units="mM"/>
        <variable name="RT_over_F" public_interface="in" units="mV"/>
        <variable name="Cai" public_interface="in" units="mM"/>
        <variable name="Cao" public_interface="in" units="mM"/>
        <variable name="V" public_interface="in" units="mV"/>
        <variable name="yCa" public_interface="in" units="dimensionless"/>
        <variable name="Open" public_interface="in" units="dimensionless"/>
        <variable name="Faraday" public_interface="in" units="coulomb_per_millimole"/>
        <variable name="PKprime" units="litre_per_farad_second"/>
        <variable name="VF_over_RT" units="dimensionless"/>
        <variable name="VFsq_over_RT" units="coulomb_per_millimole"/>
        <variable name="a1_Ca" units="mM"/>
        <variable name="a2_Ca" units="dimensionless"/>
        <variable name="a1_K" units="mM"/>
        <variable name="a2_K" units="dimensionless"/>
        <variable name="ICa" public_interface="out" units="uA_per_uF"/>
        <variable name="ICaK" public_interface="out" units="uA_per_uF"/>
        <variable name="ICamax" units="uA_per_uF"/>
        <variable name="Icabar" units="uA_per_uF"/>
        <variable name="PCa" units="litre_per_farad_second"/>
        <variable name="PK" units="litre_per_farad_second"/>
        <variable initial_value="-0.265" name="ICahalf" units="uA_per_uF"/>
        <variable initial_value="7" name="Pscale" units="dimensionless"/>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
                <eq/>
                <ci>PK</ci>
                <apply>
                    <times/>
                    <ci>Pscale</ci>
                    <cn cellml:units="litre_per_farad_second" type="e-notation">4.574<sep/>-7</cn>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>PCa</ci>
                <apply>
                    <times/>
                    <ci>Pscale</ci>
                    <cn cellml:units="litre_per_farad_second" type="e-notation">2.469<sep/>-4</cn>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>VF_over_RT</ci>
                <apply>
                    <divide/>
                    <ci>V</ci>
                    <ci>RT_over_F</ci>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>VFsq_over_RT</ci>
                <apply>
                    <times/>
                    <cn cellml:units="dimensionless">1000</cn>
                    <ci>Faraday</ci>
                    <ci>VF_over_RT</ci>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>a1_Ca</ci>
                <apply>
                    <minus/>
                    <apply>
                        <times/>
                        <cn cellml:units="mM" type="e-notation">1.0<sep/>-3</cn>
                        <apply>
                            <exp/>
                            <apply>
                                <times/>
                                <cn cellml:units="dimensionless">2</cn>
                                <ci>VF_over_RT</ci>
                            </apply>
                        </apply>
                    </apply>
                    <apply>
                        <times/>
                        <ci>Cao</ci>
                        <cn cellml:units="dimensionless">0.341</cn>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>a2_Ca</ci>
                <apply>
                    <minus/>
                    <apply>
                        <exp/>
                        <apply>
                            <times/>
                            <cn cellml:units="dimensionless">2</cn>
                            <ci>VF_over_RT</ci>
                        </apply>
                    </apply>
                    <cn cellml:units="dimensionless">1</cn>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>ICamax</ci>
                <apply>
                    <divide/>
                    <apply>
                        <times/>
                        <ci>PCa</ci>
                        <cn cellml:units="dimensionless">4</cn>
                        <ci>VFsq_over_RT</ci>
                        <ci>a1_Ca</ci>
                    </apply>
                    <ci>a2_Ca</ci>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>ICa</ci>
                <apply>
                    <times/>
                    <ci>ICamax</ci>
                    <ci>yCa</ci>
                    <ci>Open</ci>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>Icabar</ci>
                <piecewise>
                    <piece>
                        <cn cellml:units="uA_per_uF">0</cn>
                        <apply>
                            <geq/>
                            <ci>ICamax</ci>
                            <cn cellml:units="uA_per_uF">0</cn>
                        </apply>
                    </piece>
                    <otherwise>
                        <ci>ICamax</ci>
                    </otherwise>
                </piecewise>
            </apply>
            <apply>
                <eq/>
                <ci>PKprime</ci>
                <apply>
                    <divide/>
                    <ci>PK</ci>
                    <apply>
                        <plus/>
                        <cn cellml:units="dimensionless">1</cn>
                        <apply>
                            <divide/>
                            <ci>Icabar</ci>
                            <ci>ICahalf</ci>
                        </apply>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>a1_K</ci>
                <apply>
                    <minus/>
                    <apply>
                        <times/>
                        <ci>Ki</ci>
                        <apply>
                            <exp/>
                            <ci>VF_over_RT</ci>
                        </apply>
                    </apply>
                    <ci>Ko</ci>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>a2_K</ci>
                <apply>
                    <minus/>
                    <apply>
                        <exp/>
                        <ci>VF_over_RT</ci>
                    </apply>
                    <cn cellml:units="dimensionless">1</cn>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>ICaK</ci>
                <apply>
                    <divide/>
                    <apply>
                        <times/>
                        <ci>PKprime</ci>
                        <ci>Open</ci>
                        <ci>yCa</ci>
                        <ci>VFsq_over_RT</ci>
                        <ci>a1_K</ci>
                    </apply>
                    <ci>a2_K</ci>
                </apply>
            </apply>
        </math>
    </component>
    <component name="INa">
        <variable name="V" public_interface="in" units="mV"/>
        <variable name="time" public_interface="in" units="ms"/>
        <variable name="Temp_Scale" units="dimensionless"/>
        <variable name="alpha1" units="per_ms"/>
        <variable name="beta1" units="per_ms"/>
        <variable name="gamma1" units="per_ms"/>
        <variable name="Delta1" units="per_ms"/>
        <variable name="On" units="per_ms"/>
        <variable name="Of" units="per_ms"/>
        <variable name="GammaGamma" units="per_ms"/>
        <variable name="DeltaDelta" units="per_ms"/>
        <variable name="epsilon" units="per_ms"/>
        <variable name="omega_na" units="per_ms"/>
        <variable name="rho" units="per_ms"/>
        <variable name="mu" units="per_ms"/>
        <variable name="Cn" units="per_ms"/>
        <variable name="Cf" units="per_ms"/>
        <variable name="parameter_a" units="dimensionless"/>
        <variable name="k12" units="per_ms"/>
        <variable name="k23" units="per_ms"/>
        <variable name="k34" units="per_ms"/>
        <variable name="k45" units="per_ms"/>
        <variable name="k56" units="per_ms"/>
        <variable name="k67" units="per_ms"/>
        <variable name="k89" units="per_ms"/>
        <variable name="k910" units="per_ms"/>
        <variable name="k1011" units="per_ms"/>
        <variable name="k1112" units="per_ms"/>
        <variable name="k1213" units="per_ms"/>
        <variable name="k57" units="per_ms"/>
        <variable name="k21" units="per_ms"/>
        <variable name="k32" units="per_ms"/>
        <variable name="k43" units="per_ms"/>
        <variable name="k54" units="per_ms"/>
        <variable name="k65" units="per_ms"/>
        <variable name="k76" units="per_ms"/>
        <variable name="k98" units="per_ms"/>
        <variable name="k109" units="per_ms"/>
        <variable name="k1110" units="per_ms"/>
        <variable name="k1211" units="per_ms"/>
        <variable name="k1312" units="per_ms"/>
        <variable name="k75" units="per_ms"/>
        <variable name="k81" units="per_ms"/>
        <variable name="k92" units="per_ms"/>
        <variable name="k103" units="per_ms"/>
        <variable name="k114" units="per_ms"/>
        <variable name="k125" units="per_ms"/>
        <variable name="k136" units="per_ms"/>
        <variable name="k18" units="per_ms"/>
        <variable name="k29" units="per_ms"/>
        <variable name="k310" units="per_ms"/>
        <variable name="k411" units="per_ms"/>
        <variable name="k512" units="per_ms"/>
        <variable name="k613" units="per_ms"/>
        <variable initial_value="0.1437575649" name="na1" public_interface="out" units="dimensionless"/>
        <variable initial_value="0.0417776208" name="na2" public_interface="out" units="dimensionless"/>
        <variable initial_value="0.004552898364" name="na3" public_interface="out" units="dimensionless"/>
        <variable initial_value="2.20520743e-4" name="na4" public_interface="out" units="dimensionless"/>
        <variable initial_value="4.005266484e-6" name="na5" public_interface="out" units="dimensionless"/>
        <variable initial_value="1.57442749e-8" name="na6" public_interface="out" units="dimensionless"/>
        <variable initial_value="2.856607179e-9" name="na7" public_interface="out" units="dimensionless"/>
        <variable initial_value="0.4749950008" name="na8" public_interface="out" units="dimensionless"/>
        <variable initial_value="0.2707214097" name="na9" public_interface="out" units="dimensionless"/>
        <variable initial_value="0.05786120057" name="na10" public_interface="out" units="dimensionless"/>
        <variable initial_value="0.005496292279" name="na11" public_interface="out" units="dimensionless"/>
        <variable initial_value="1.957874519e-4" name="na12" public_interface="out" units="dimensionless"/>
        <variable initial_value="4.17679396e-4" name="na13" public_interface="out" units="dimensionless"/>
        <variable initial_value="294.16" name="TNa" units="kelvin"/>
        <variable name="KToverH" units="per_ms"/>
        <variable name="FoverRT" units="per_mV"/>
        <variable name="RToverF" public_interface="in" units="mV"/>
        <variable name="RTNa" units="joule_per_mole"/>
        <variable name="RTNaF" units="mV"/>
        <variable name="Faraday" public_interface="in" units="coulomb_per_millimole"/>
        <variable name="Rgas" public_interface="in" units="joule_per_mole_kelvin"/>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
                <eq/>
                <ci>FoverRT</ci>
                <apply>
                    <divide/>
                    <cn cellml:units="dimensionless">1</cn>
                    <ci>RToverF</ci>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>KToverH</ci>
                <apply>
                    <divide/>
                    <apply>
                        <times/>
                        <cn cellml:units="joule_per_kelvin" type="e-notation">1.381<sep/>-23</cn>
                        <ci>TNa</ci>
                    </apply>
                    <cn cellml:units="joule_ms" type="e-notation">6.626<sep/>-31</cn>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>RTNa</ci>
                <apply>
                    <times/>
                    <ci>Rgas</ci>
                    <ci>TNa</ci>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>RTNaF</ci>
                <apply>
                    <divide/>
                    <apply>
                        <times/>
                        <ci>Rgas</ci>
                        <ci>TNa</ci>
                    </apply>
                    <ci>Faraday</ci>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>Temp_Scale</ci>
                <cn cellml:units="dimensionless">1.38862291252871</cn>
            </apply>
            <apply>
                <eq/>
                <ci>alpha1</ci>
                <apply>
                    <times/>
                    <ci>Temp_Scale</ci>
                    <ci>KToverH</ci>
                    <apply>
                        <exp/>
                        <apply>
                            <plus/>
                            <apply>
                                <divide/>
                                <apply>
                                    <minus/>
                                    <cn cellml:units="joule_per_mole">114007.462700232</cn>
                                </apply>
                                <ci>RTNa</ci>
                            </apply>
                            <apply>
                                <divide/>
                                <cn cellml:units="joule_per_mole_kelvin">224.114</cn>
                                <ci>Rgas</ci>
                            </apply>
                            <apply>
                                <divide/>
                                <apply>
                                    <times/>
                                    <cn cellml:units="dimensionless">0.286374268596235</cn>
                                    <ci>V</ci>
                                </apply>
                                <ci>RTNaF</ci>
                            </apply>
                        </apply>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>beta1</ci>
                <apply>
                    <times/>
                    <ci>Temp_Scale</ci>
                    <ci>KToverH</ci>
                    <apply>
                        <exp/>
                        <apply>
                            <plus/>
                            <apply>
                                <divide/>
                                <apply>
                                    <minus/>
                                    <cn cellml:units="joule_per_mole">272470.273489681</cn>
                                </apply>
                                <ci>RTNa</ci>
                            </apply>
                            <apply>
                                <divide/>
                                <cn cellml:units="joule_per_mole_kelvin">708.146</cn>
                                <ci>Rgas</ci>
                            </apply>
                            <apply>
                                <divide/>
                                <apply>
                                    <times/>
                                    <apply>
                                        <minus/>
                                        <cn cellml:units="dimensionless">2.28528417586424</cn>
                                    </apply>
                                    <ci>V</ci>
                                </apply>
                                <ci>RTNaF</ci>
                            </apply>
                        </apply>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>gamma1</ci>
                <apply>
                    <times/>
                    <ci>Temp_Scale</ci>
                    <ci>KToverH</ci>
                    <apply>
                        <exp/>
                        <apply>
                            <plus/>
                            <apply>
                                <divide/>
                                <apply>
                                    <minus/>
                                    <cn cellml:units="joule_per_mole">196336.575735923</cn>
                                </apply>
                                <ci>RTNa</ci>
                            </apply>
                            <apply>
                                <divide/>
                                <cn cellml:units="joule_per_mole_kelvin">529.952</cn>
                                <ci>Rgas</ci>
                            </apply>
                            <apply>
                                <divide/>
                                <apply>
                                    <times/>
                                    <cn cellml:units="dimensionless">2.78084918596045</cn>
                                    <ci>V</ci>
                                </apply>
                                <ci>RTNaF</ci>
                            </apply>
                        </apply>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>Delta1</ci>
                <apply>
                    <times/>
                    <ci>Temp_Scale</ci>
                    <ci>KToverH</ci>
                    <apply>
                        <exp/>
                        <apply>
                            <plus/>
                            <apply>
                                <divide/>
                                <apply>
                                    <minus/>
                                    <cn cellml:units="joule_per_mole">133689.9304091</cn>
                                </apply>
                                <ci>RTNa</ci>
                            </apply>
                            <apply>
                                <divide/>
                                <cn cellml:units="joule_per_mole_kelvin">229.205</cn>
                                <ci>Rgas</ci>
                            </apply>
                            <apply>
                                <divide/>
                                <apply>
                                    <times/>
                                    <apply>
                                        <minus/>
                                        <cn cellml:units="dimensionless">1.55804214553883</cn>
                                    </apply>
                                    <ci>V</ci>
                                </apply>
                                <ci>RTNaF</ci>
                            </apply>
                        </apply>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>On</ci>
                <apply>
                    <times/>
                    <ci>Temp_Scale</ci>
                    <ci>KToverH</ci>
                    <apply>
                        <exp/>
                        <apply>
                            <plus/>
                            <apply>
                                <divide/>
                                <apply>
                                    <minus/>
                                    <cn cellml:units="joule_per_mole">62123.0784380481</cn>
                                </apply>
                                <ci>RTNa</ci>
                            </apply>
                            <apply>
                                <divide/>
                                <cn cellml:units="joule_per_mole_kelvin">39.295</cn>
                                <ci>Rgas</ci>
                            </apply>
                            <apply>
                                <divide/>
                                <apply>
                                    <times/>
                                    <cn cellml:units="dimensionless">0.288816042743232</cn>
                                    <ci>V</ci>
                                </apply>
                                <ci>RTNaF</ci>
                            </apply>
                        </apply>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>Of</ci>
                <apply>
                    <times/>
                    <ci>Temp_Scale</ci>
                    <ci>KToverH</ci>
                    <apply>
                        <exp/>
                        <apply>
                            <plus/>
                            <apply>
                                <divide/>
                                <apply>
                                    <minus/>
                                    <cn cellml:units="joule_per_mole">97657.8497137015</cn>
                                </apply>
                                <ci>RTNa</ci>
                            </apply>
                            <apply>
                                <divide/>
                                <cn cellml:units="joule_per_mole_kelvin">1.51</cn>
                                <ci>Rgas</ci>
                            </apply>
                            <apply>
                                <divide/>
                                <apply>
                                    <times/>
                                    <cn cellml:units="dimensionless">0.0684861993100685</cn>
                                    <ci>V</ci>
                                </apply>
                                <ci>RTNaF</ci>
                            </apply>
                        </apply>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>GammaGamma</ci>
                <apply>
                    <times/>
                    <ci>Temp_Scale</ci>
                    <ci>KToverH</ci>
                    <apply>
                        <exp/>
                        <apply>
                            <plus/>
                            <apply>
                                <divide/>
                                <cn cellml:units="joule_per_mole">116431.142142348</cn>
                                <ci>RTNa</ci>
                            </apply>
                            <apply>
                                <divide/>
                                <apply>
                                    <minus/>
                                    <cn cellml:units="joule_per_mole_kelvin">578.317</cn>
                                </apply>
                                <ci>Rgas</ci>
                            </apply>
                            <apply>
                                <divide/>
                                <apply>
                                    <times/>
                                    <cn cellml:units="dimensionless">0.764126011745707</cn>
                                    <ci>V</ci>
                                </apply>
                                <ci>RTNaF</ci>
                            </apply>
                        </apply>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>DeltaDelta</ci>
                <apply>
                    <times/>
                    <ci>Temp_Scale</ci>
                    <ci>KToverH</ci>
                    <apply>
                        <exp/>
                        <apply>
                            <plus/>
                            <apply>
                                <divide/>
                                <apply>
                                    <minus/>
                                    <cn cellml:units="joule_per_mole">55700.6624658307</cn>
                                </apply>
                                <ci>RTNa</ci>
                            </apply>
                            <apply>
                                <divide/>
                                <apply>
                                    <minus/>
                                    <cn cellml:units="joule_per_mole_kelvin">130.639</cn>
                                </apply>
                                <ci>Rgas</ci>
                            </apply>
                            <apply>
                                <divide/>
                                <apply>
                                    <times/>
                                    <apply>
                                        <minus/>
                                        <cn cellml:units="dimensionless">3.64981672927078</cn>
                                    </apply>
                                    <ci>V</ci>
                                </apply>
                                <ci>RTNaF</ci>
                            </apply>
                        </apply>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>epsilon</ci>
                <apply>
                    <times/>
                    <ci>Temp_Scale</ci>
                    <ci>KToverH</ci>
                    <apply>
                        <exp/>
                        <apply>
                            <plus/>
                            <apply>
                                <divide/>
                                <apply>
                                    <minus/>
                                    <cn cellml:units="joule_per_mole">85800.3675578326</cn>
                                </apply>
                                <ci>RTNa</ci>
                            </apply>
                            <apply>
                                <divide/>
                                <cn cellml:units="joule_per_mole_kelvin">70.078</cn>
                                <ci>Rgas</ci>
                            </apply>
                        </apply>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>omega_na</ci>
                <apply>
                    <times/>
                    <ci>Temp_Scale</ci>
                    <ci>KToverH</ci>
                    <apply>
                        <exp/>
                        <apply>
                            <plus/>
                            <apply>
                                <divide/>
                                <apply>
                                    <minus/>
                                    <cn cellml:units="joule_per_mole">121955.166154864</cn>
                                </apply>
                                <ci>RTNa</ci>
                            </apply>
                            <apply>
                                <divide/>
                                <cn cellml:units="joule_per_mole_kelvin">225.175</cn>
                                <ci>Rgas</ci>
                            </apply>
                        </apply>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>rho</ci>
                <apply>
                    <times/>
                    <ci>Temp_Scale</ci>
                    <ci>KToverH</ci>
                    <apply>
                        <exp/>
                        <apply>
                            <plus/>
                            <apply>
                                <divide/>
                                <apply>
                                    <minus/>
                                    <cn cellml:units="joule_per_mole">147813.990005035</cn>
                                </apply>
                                <ci>RTNa</ci>
                            </apply>
                            <apply>
                                <divide/>
                                <cn cellml:units="joule_per_mole_kelvin">338.915</cn>
                                <ci>Rgas</ci>
                            </apply>
                            <apply>
                                <divide/>
                                <apply>
                                    <times/>
                                    <cn cellml:units="dimensionless">2.1360043702126</cn>
                                    <ci>V</ci>
                                </apply>
                                <ci>RTNaF</ci>
                            </apply>
                        </apply>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>mu</ci>
                <apply>
                    <times/>
                    <ci>Temp_Scale</ci>
                    <ci>KToverH</ci>
                    <apply>
                        <exp/>
                        <apply>
                            <plus/>
                            <apply>
                                <divide/>
                                <apply>
                                    <minus/>
                                    <cn cellml:units="joule_per_mole">121322.143275242</cn>
                                </apply>
                                <ci>RTNa</ci>
                            </apply>
                            <apply>
                                <divide/>
                                <cn cellml:units="joule_per_mole_kelvin">193.265</cn>
                                <ci>Rgas</ci>
                            </apply>
                            <apply>
                                <divide/>
                                <apply>
                                    <times/>
                                    <apply>
                                        <minus/>
                                        <cn cellml:units="dimensionless">1.74290267020903</cn>
                                    </apply>
                                    <ci>V</ci>
                                </apply>
                                <ci>RTNaF</ci>
                            </apply>
                        </apply>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>Cn</ci>
                <apply>
                    <times/>
                    <ci>Temp_Scale</ci>
                    <ci>KToverH</ci>
                    <apply>
                        <exp/>
                        <apply>
                            <plus/>
                            <apply>
                                <divide/>
                                <apply>
                                    <minus/>
                                    <cn cellml:units="joule_per_mole">287913.446530953</cn>
                                </apply>
                                <ci>RTNa</ci>
                            </apply>
                            <apply>
                                <divide/>
                                <cn cellml:units="joule_per_mole_kelvin">786.217</cn>
                                <ci>Rgas</ci>
                            </apply>
                        </apply>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>Cf</ci>
                <apply>
                    <times/>
                    <ci>Temp_Scale</ci>
                    <ci>KToverH</ci>
                    <apply>
                        <exp/>
                        <apply>
                            <plus/>
                            <apply>
                                <divide/>
                                <apply>
                                    <minus/>
                                    <cn cellml:units="joule_per_mole">59565.2236284584</cn>
                                </apply>
                                <ci>RTNa</ci>
                            </apply>
                            <apply>
                                <divide/>
                                <cn cellml:units="joule_per_mole_kelvin">0.00711</cn>
                                <ci>Rgas</ci>
                            </apply>
                        </apply>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>parameter_a</ci>
                <cn cellml:units="dimensionless">1.40042625477401</cn>
            </apply>
            <apply>
                <eq/>
                <ci>k12</ci>
                <apply>
                    <times/>
                    <cn cellml:units="dimensionless">4</cn>
                    <ci>alpha1</ci>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>k23</ci>
                <apply>
                    <times/>
                    <cn cellml:units="dimensionless">3</cn>
                    <ci>alpha1</ci>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>k34</ci>
                <apply>
                    <times/>
                    <cn cellml:units="dimensionless">2</cn>
                    <ci>alpha1</ci>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>k45</ci>
                <ci>alpha1</ci>
            </apply>
            <apply>
                <eq/>
                <ci>k56</ci>
                <ci>gamma1</ci>
            </apply>
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                <title xmlns="http://cellml.org/tmp-documentation">A computational model of the human left-ventricular epicardial myocyte</title>
                <author xmlns="http://cellml.org/tmp-documentation">
                    <firstname xmlns="http://cellml.org/tmp-documentation">Steven</firstname>
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            This CellML model runs in OpenCell and COR to reproduce the published results. The units have been checked and they are consistent.
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                <title xmlns="http://cellml.org/tmp-documentation">Model Structure</title>
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ABSTRACT: A computational model of the human left-ventricular epicardial myocyte is presented. Models of each of the major ionic currents present in these cells are formulated and validated using experimental data obtained from studies of recombinant human ion channels and/or whole-cell recording from single myocytes isolated from human left-ventricular subepicardium. Continuous-time Markov chain models for the gating of the fast Na(+) current, transient outward current, rapid component of the delayed rectifier current, and the L-type calcium current are modified to represent human data at physiological temperature. A new model for the gating of the slow component of the delayed rectifier current is formulated and validated against experimental data. Properties of calcium handling and exchanger currents are altered to appropriately represent the dynamics of intracellular ion concentrations. The model is able to both reproduce and predict a wide range of behaviors observed experimentally including action potential morphology, ionic currents, intracellular calcium transients, frequency dependence of action-potential duration, Ca(2+)-frequency relations, and extrasystolic restitution/post-extrasystolic potentiation. The model therefore serves as a useful tool for investigating mechanisms of arrhythmia and consequences of drug-channel interactions in the human left-ventricular myocyte.
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The original paper reference is cited below:
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A computational model of the human left-ventricular epicardial myocyte, Vivek Iyer, Reza Mazhari and Raimond L. Winslow, 2004, <emphasis xmlns="http://cellml.org/tmp-documentation">Biophysical Journal</emphasis>, 87, 1507-1525. <ulink xmlns="http://cellml.org/tmp-documentation" url="http://www.ncbi.nlm.nih.gov/pubmed/15345532">PubMed ID: 15345532</ulink>
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                    <caption xmlns="http://cellml.org/tmp-documentation">A schematic diagram describing the ion movement across the cell surface membrane and the sarcoplasmic reticulum, which are described by the Iyer <emphasis xmlns="http://cellml.org/tmp-documentation">et al.</emphasis> 2004 mathematical model of the human left-ventricular epicardial myocyte.</caption>
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            <rdf:value xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xml:lang="en" xmlns:xml="http://www.w3.org/XML/1998/namespace">This file is a CellML description of Iyer et al's model of the human left ventricular epicardial myocyte as described in the paper "A Computational model of the human left-ventricular epicardial myocyte"</rdf:value>
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            <W3CDTF xmlns="http://purl.org/dc/terms/" xml:lang="en" xmlns:xml="http://www.w3.org/XML/1998/namespace">2004-09-00 00:00</W3CDTF>
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            <title xmlns="http://purl.org/dc/elements/1.1/" xml:lang="en" xmlns:xml="http://www.w3.org/XML/1998/namespace">Biophysical Journal</title>
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            <FN xmlns="http://www.w3.org/2001/vcard-rdf/3.0#" xml:lang="en" xmlns:xml="http://www.w3.org/XML/1998/namespace">James Lawson</FN>
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