About this model

Original publication:
 Kernik et al. (2019): "A computational model of induced pluripotent stem-cell derived cardiomyocytes incorporating experimental variability from multiple data sources" J Physiol. 2019 Sep 1; 597(17): 4533-4564.

Figure 10

Action potential in the baseline model

The developed baseline model including all the channels and current was optimized to reproduce the spontaneous beating of actional potential as a e key feature of the immature iPSC-CM phenotype which shows in figure 10.

Channels.cellml is the main CellML file which shows the I-V curves for different channels fitted to different experimental data from multiple laboratories. Its associated SED-ML file contains all the simulation settings. All the CellML files and SED-ML files need to be download in a same folder (gating_Ik1, parameter_Ik1, gating_Ikr, parameter_Ikr, gating_Iks, parameter_Iks, gating_Ito, parameter_Ito, gating_Ica, parameter_Ica, gating_Icat, gating_Ina, parameter_Ina, gating_If, parameter_If, parameter, unit) as well as python scripts ( In the python script, required SED-ML file (Channels.sedml) is loaded into the script and by running the code all the required currents are calculated, and the following figure is reproduced. is used to generate the simulation and reproduces the graph shown in Figure 11 in the original study. In order to reproduce Figure 11, once all the files are downloaded to the same folder, execute the following script from the command line (command prompt):

cd [PathToThisFile]


time course of the spontaneously beating APs in the baseline model