You are here: Home / Exposures / Aguda, B, 1999 / A quantitative analysis of the kinetics of the G2 DNA damage checkpoint system

Model Mathematics

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Component: environment

Component: rate_constants

Component: Chk1P

\frac{d}{d time} (Chk1P) = V_1 - V_n1

Component: Rad3

\frac{d}{d time} (Rad3) = V_4 - V_5

Component: p53

\frac{d}{d time} (p53) = V_10 - V_11

Component: preMPF

\frac{d}{d time} (preMPF) = V_14 + V_n9 - V_9

Component: MPF

\frac{d}{d time} (MPF) = V_9 + V_n23 - (V_n9 + V_23 + V_15)

Component: p21

\frac{d}{d time} (p21) = V_20 + V_21 + V_n23 - (V_22 + V_23)

Component: p21_MPF

\frac{d}{d time} (p21_MPF) = V_23 - V_n23

Component: iCdc25

\frac{d}{d time} (iCdc25) = V_n7 + V_n3_+ V_in - (V_7 + V_2_)

Component: iCdc25Ps216

\frac{d}{d time} (iCdc25Ps216) = V_2_+ V_n18 - (V_18 + V_3_)

Component: iCdc25Ps216_protein1433

\frac{d}{d time} (iCdc25Ps216_protein1433) = V_3_- (V_n3_+ V_ex)

Component: aCdc25

\frac{d}{d time} (aCdc25) = V_7 + V_n2 - (V_n7 + V_2)

Component: aCdc25Ps216

\frac{d}{d time} (aCdc25Ps216) = V_2 + V_18 - (V_n2 + V_n18)

Component: protein1433

\frac{d}{d time} (protein1433) = V_6 + V_13 + V_n3_- (V_3_+ V_12)

Component: Wee1

\frac{d}{d time} (Wee1) = V_16 + V_n8 - V_8

Component: Wee1P

\frac{d}{d time} (Wee1P) = V_8 - (V_n8 + V_17)

Component: aCdc25_T

aCdc25_T = aCdc25 + aCdc25Ps216

Component: V_1

Chk1 = Chk1_T - Chk1P V_1 = k1 Chk1 Rad3

Component: V_n1

V_n1 = kn1 Chk1P

Component: V_2

V_2 = k2 Chk1P aCdc25 + kctak1 aCdc25

Component: V_n2

V_n2 = kn2 aCdc25Ps216

Component: V_2_

V_2_= k2_Chk1P iCdc25 + kctak1_iCdc25

Component: V_3_

V_3_= k3_iCdc25Ps216 protein1433

Component: V_n3_

V_n3_= kn3_iCdc25Ps216_protein1433

Component: V_4

V_4 = k4

Component: V_5

V_5 = k5 Rad3

Component: V_6

V_6 = k6 p53

Component: V_7

V_7 = k7 MPF iCdc25 + kPlk1 iCdc25

Component: V_n7

V_n7 = kn7 aCdc25

Component: V_8

V_8 = k8 MPF Wee1 + k8_Wee1

Component: V_n8

V_n8 = kn8 Wee1P

Component: V_9

V_9 = k9 (aCdc25 + aCdc25Ps216) preMPF + k9_preMPF

Component: V_n9

V_n9 = kn9 MPF Wee1

Component: V_10

V_10 = k10

Component: V_11

V_11 = k11 p53

Component: V_12

V_12 = k12 protein1433

Component: V_13

V_13 = k13

Component: V_14

V_14 = \frac{k14}{1 + k14_p53} 1

Component: V_15

V_15 = k15 {MPF}^{2}

Component: V_16

V_16 = k16

Component: V_17

V_17 = k17 Wee1P

Component: V_18

V_18 = k18 MPF iCdc25Ps216 + kPlk1_iCdc25Ps216

Component: V_n18

V_n18 = kn18 aCdc25Ps216

Component: V_20

V_20 = k20 p53

Component: V_21

V_21 = k21

Component: V_22

V_22 = k22 p21

Component: V_23

V_23 = k23 MPF p21

Component: V_n23

V_n23 = kn23 p21_MPF

Component: V_ex

V_ex = kex iCdc25Ps216_protein1433

Component: V_in

Source: Derived from workspace Aguda, B, 1999 at changeset a75faa573b30.

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A quantitative analysis of the kinetics of the G2 DNA damage checkpoint system