NHE3 Model - Figure 2

Figure 2

This is the general mathematical model for the NHE3 model with modifications to enable simulations which are capable of reproducing Figure 2 in the original paper. The simulation experiment for this model can be obtained by loading the corresponding SED-ML document into OpenCOR and executing the simulation. The results of which are shown below. A rendering of the mathematical model itself is available here.

In Figure 2, the Na⁺ influx is computed for a range of external pH when NH₄⁺ is not present. Internal and external Na⁺ concentrations are fixed at 0.0 and 0.1 mM; internal pH is 6; and external pH is varied from 6 to 8. (top) Na⁺ flux is shown as a function of the external pH. (bottom) Reciprocal flux is shown as a function of the external H⁺ concentration.

A screenshot illustrating the results when the associated SED-ML document is loaded into OpenCOR and the simulation executed.

This can be reproduced directly from the repository by choosing the Launch with OpenCOR link from the Views Available.