<?xml version='1.0'?>
<!-- This CellML file was generated from:
Weinstein, Alan M. "A mathematical model of the outer medullary collecting duct of the rat." American Journal of Physiology-Renal Physiology 279.1 (2000): F24-F45.
The results are compared with Figure 6 in:
Chang, Hangil, and Toshiro Fujita. "A numerical model of acid-base transport in rat distal tubule." American Journal of Physiology-Renal Physiology 281.2 (2001): F222-F243.-->
<model cmeta:id="Weinstein_2000_HATPase" name="Weinstein_2000_HATPase" xmlns="http://www.cellml.org/cellml/1.1#" xmlns:cellml="http://www.cellml.org/cellml/1.1#" xmlns:cmeta="http://www.cellml.org/metadata/1.0#" xmlns:xlink="http://www.w3.org/1999/xlink">
<import xlink:href="Units/Units.cellml">
<units name="mM" units_ref="mM"/>
<units name="mM_per_s" units_ref="mM_per_s"/>
</import>
<import xlink:href="Weinstein_2000_HATPase.cellml">
<component component_ref="H_ATPase" name="H_ATPase"/>
</import>
<component name="environment">
<variable name="time" public_interface="out" units="second"/>
</component>
<component name="concentrations">
<variable name="time" public_interface="in" units="second"/>
<variable name="H_int" public_interface="out" units="mM"/>
<variable name="H_ext" public_interface="out" units="mM"/>
<variable initial_value="-0.03" name="psi_int" units="volt"/>
<variable initial_value="0.0" name="psi_ext" units="volt"/>
<variable name="psi" public_interface="out" units="volt"/>
<variable initial_value="7.5" name="pH_int" units="dimensionless"/>
<variable initial_value="4.0" name="pH_ext" units="dimensionless"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>psi</ci>
<apply>
<minus/>
<ci>psi_ext</ci>
<ci>psi_int</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>H_int</ci>
<apply>
<times/>
<cn cellml:units="mM">1e3</cn>
<apply>
<power/>
<cn cellml:units="dimensionless">10</cn>
<apply>
<minus/>
<ci>pH_int</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>H_ext</ci>
<apply>
<times/>
<cn cellml:units="mM">1e3</cn>
<apply>
<power/>
<cn cellml:units="dimensionless">10</cn>
<apply>
<minus/>
<ci>pH_ext</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>pH_int</ci>
</apply>
<cn cellml:units="per_s">0.0</cn>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>pH_ext</ci>
</apply>
<cn cellml:units="per_s">0.1</cn>
</apply>
</math>
</component>
<component name="fluxes">
<variable name="J_Vtype_H_Max" public_interface="in" units="mM_per_s"/>
<variable name="J_Vtype_H" public_interface="in" units="mM_per_s"/>
<variable name="plot" units="dimensionless"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>plot</ci>
<apply>
<divide/>
<ci>J_Vtype_H</ci>
<ci>J_Vtype_H_Max</ci>
</apply>
</apply>
</math>
</component>
<connection>
<map_components component_1="concentrations" component_2="H_ATPase"/>
<map_variables variable_1="H_int" variable_2="H_int"/>
<map_variables variable_1="H_ext" variable_2="H_ext"/>
<map_variables variable_1="psi" variable_2="psi"/>
</connection>
<connection>
<map_components component_1="fluxes" component_2="H_ATPase"/>
<map_variables variable_1="J_Vtype_H" variable_2="J_Vtype_H"/>
<map_variables variable_1="J_Vtype_H_Max" variable_2="J_Vtype_H_Max"/>
</connection>
<connection>
<map_components component_1="concentrations" component_2="environment"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
</model>
